International Journal of Radiation Oncology * Biology * Physics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Late urinary toxicity and QOL with pelvic radiotherapy for high-risk prostate cancer: Dose-effect relations in the POP-RT randomized phase III trial
We report updated late urinary adverse effects and bladder dose-effect relations within this trial. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 27, 2024 Category: Radiology Authors: Priyamvada Maitre, Guncha Maheshwari, Joyita Sarkar, Pallavi Singh, Sadhana Kannan, Supriya Dutta, Reena Phurailatpam, Vysakh Raveendran, Gagan Prakash, Santosh Menon, Amit Joshi, Mahendra Pal, Amandeep Arora, Vedang Murthy Tags: Clinical Investigation Source Type: research

Pain Relief –Related Structural Brain Alterations in Trigeminal Neuralgia Induced by Noninvasive Stereotactic Radiosurgery: A Pilot Study
Trigeminal neuralgia (TN) is a chronic pain disorder defined by unilateral shock-like pain in at least one division of the trigeminal nerve. Although several studies have investigated structural brain plasticity in patients with TN, treatment-induced alterations remain largely uninvestigated. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 22, 2024 Category: Radiology Authors: Jonas Kolodziej, Bogdan Pintea, Jan Patrick Bostr öm, Burkhard Pleger Tags: Brief Report Source Type: research

Efficacy and safety of postoperative adjuvant radiotherapy in resected nasal cavity and paranasal sinus mucosal melanoma: A Combined Analysis
Mucosal melanoma of the nasal cavity and paranasal sinuses (NPMM) is a highly aggressive disease. The role of postoperative adjuvant radiotherapy is controversial. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 22, 2024 Category: Radiology Authors: Bin Lian, Yue Yang, Baomin Zheng, Lu Si, Li Zhou, ZhiHong Chi, Lili Mao, Xuan Wang, Siming Li, Juan Li, LiPing Wang, Jun Guo, Chuanliang Cui Tags: Clinical Investigation Source Type: research

Pain-relief related structural brain alterations in trigeminal neuralgia induced by non-invasive stereotactic radiosurgery – a pilot study
Trigeminal neuralgia (TN) is a devastating chronic pain disorder, defined by unilateral shock like pain in at least one division of the trigeminal nerve. Although several studies have investigated structural brain plasticity in TN patients, treatment-induced alterations remain largely uninvestigated. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 22, 2024 Category: Radiology Authors: Jonas Kolodziej, Bogdan Pintea, Jan Patrick Bostr öm, Burkhard Pleger Tags: Brief Report Source Type: research

Long-term outcomes after concurrent once- or twice-daily chemoradiation in limited-stage small-cell lung cancer: a brief report from the CONVERT trial
CONVERT was a phase 3 international randomized clinical trial comparing once-daily (OD) and twice-daily (BD) radiation therapy (RT). This updated analysis describes the 6.5 year outcomes of these regimes delivered with conformal techniques. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 21, 2024 Category: Radiology Authors: Gerard M Walls, Hitesh Mistry, Fabrice Barlesi, Andrea Bezjak, Cecile Le Pechoux, Mary O'Brien, Jan P Van Meerbeeck, Fiona Blackhall, Corinne Faivre-Finn Tags: Brief Report Source Type: research

Recent Trends in “Manels” and Gender Representation Among Panelists at North American Annual Radiation Oncology Meetings
Achieving gender equity in radiation oncology is an important goal, as a smaller proportion of women enter radiation oncology residency compared with those graduating from medical school. As invited speaking opportunities at academic medical conferences are vital for promotion/tenure, we investigated the prevalence of all-men panels ( “manels”) at American Society for Radiation Oncology (ASTRO) and Canadian Society of Radiation Oncology (CARO) annual meetings. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 18, 2024 Category: Radiology Authors: Laura Burgess, Anushka Ghosh, Beow Y. Yeap, Nabeel Rasheed, Siri Ragala, Anita Nwiloh, Henning Willers, Anthony Zietman, Neha Vapiwala, Sophia C. Kamran Tags: Brief Report Source Type: research

Molecular changes in breast cancer induced by radiation therapy
Breast cancer treatments are based on prognostic clinicopathological features that form the basis for therapeutic guidelines. While the utilization of these guidelines has decreased breast cancer-associated mortality rates over the past three decades, they are not adequate for individualized therapy. Radiation therapy (RT) is the backbone of breast cancer treatment. Although a highly successful therapeutic modality clinically, from a biological perspective, preclinical studies have shown RT to have the potential to alter tumor cell phenotype, immunogenicity and the surrounding microenvironment, potentially changing the beh...
Source: International Journal of Radiation Oncology * Biology * Physics - March 18, 2024 Category: Radiology Authors: Kim Sheva, Sangita Roy Chowdhury, Nataly Kravchenko-Balasha, Amichay Meirovitz Tags: Critical Review Source Type: research

Recent Trends of “Manels” and Gender Representation Among Panelists at North American Annual Radiation Oncology Meetings
Achieving gender equity in radiation oncology is an important goal as a smaller proportion of women enter radiation oncology residency compared to those graduating medical school. As invited speaking opportunities at academic medical conferences are vital for promotion/tenure, we investigated the prevalence of all-men panels ( “manels”) at ASTRO and CARO Annual Meetings. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 18, 2024 Category: Radiology Authors: Laura Burgess, Anushka Ghosh, Beow Y. Yeap, Nabeel Rasheed, Siri Ragala, Anita Nwiloh, Henning Willers, Anthony Zietman, Neha Vapiwala, Sophia C. Kamran Tags: Brief Report Source Type: research

An Analysis of Positron Emission Tomography Maximum Standard Uptake Value Among Patients With Head and Neck Cancer Receiving Photon and Proton Radiation
One main advantage of proton therapy versus photon therapy is its precise radiation delivery to targets without exit dose, resulting in lower dose to surrounding healthy tissues. This is critical, given the proximity of head and neck tumors to normal structures. However, proton planning requires careful consideration of factors, including air-tissue interface, anatomic uncertainties, surgical artifacts, weight fluctuations, rapid tumor response, and daily variations in setup and anatomy, as these heterogeneities can lead to inaccuracies in targeting and creating unwarranted hotspots to a greater extent than photon radiatio...
Source: International Journal of Radiation Oncology * Biology * Physics - March 16, 2024 Category: Radiology Authors: Irini Youssef, Nader Mohamed, Daniel Kallini, Kaveh Zakeri, Haibo Lin, Dong Han, Hang Qi, Anton Nosov, Nadeem Riaz, Linda Chen, Yao Yu, Lara Ann Dunn, Eric J. Sherman, Rick Wray, Heiko Sch öder, Nancy Y. Lee Tags: Brief Report Source Type: research

An Analysis of PET Maximum SUV Among Head and Neck Cancer Patients Receiving Photon and Proton Radiation
One main advantage of proton therapy versus photon therapy is its precise radiation delivery to targets without exit dose, resulting in lower dose to surrounding healthy tissues. This is critical given the proximity of head and neck tumors to normal structures. However, proton planning requires careful consideration of factors including air-tissue interface, anatomical uncertainties, surgical artifacts, weight fluctuations, rapid tumor response, and daily variations in setup and anatomy, as these heterogeneities can lead to inaccuracies in targeting and creating unwarranted hotspots to a greater extent than photon radiatio...
Source: International Journal of Radiation Oncology * Biology * Physics - March 16, 2024 Category: Radiology Authors: Irini Youssef, Nader Mohamed, Daniel Kallini, Kaveh Zakeri, Haibo Lin, Dong Han, Hang Qi, Anton Nosov, Nadeem Riaz, Linda Chen, Yao Yu, Lara Ann Dunn, Eric J. Sherman, Rick Wray, Heiko Sch öder, Nancy Y. Lee Source Type: research

Simultaneous Focal Boost With Stereotactic Radiation Therapy for Localized Intermediate- to High-Risk Prostate Cancer: Primary Outcomes of the SPARC Phase 2 Trial
This study evaluated the toxicity and quality of life (QoL) with CyberKnife-based SBRT and simultaneous integrated boost in localized prostate cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 15, 2024 Category: Radiology Authors: Binnaz Yasar, Yae-Eun Suh, Ewan Chapman, Luke Nicholls, Daniel Henderson, Caroline Jones, Kirsty Morrison, Emma Wells, Julia Henderson, Carole Meehan, Aslam Sohaib, Helen Taylor, Alison Tree, Nicholas van As Tags: CLINICAL INVESTIGATION Source Type: research

ClonoScreen3D – A Novel 3-Dimensional Clonogenic Screening Platform for Identification of Radiosensitizers for Glioblastoma
Glioblastoma (GBM) is a lethal brain tumor. Standard-of-care treatment comprising surgery, radiation, and chemotherapy results in median survival rates of 12 to 15 months. Molecular-targeted agents identified using conventional 2-dimensional (2D) in vitro models of GBM have failed to improve outcome in patients, rendering such models inadequate for therapeutic target identification. A previously developed 3D GBM in vitro model that recapitulates key GBM clinical features and responses to molecular therapies was investigated for utility for screening novel radiation-drug combinations using gold-standard clonogenic survival ...
Source: International Journal of Radiation Oncology * Biology * Physics - March 15, 2024 Category: Radiology Authors: Mark R. Jackson, Amanda R. Richards, Abdul-Basit Ayoola Oladipupo, Sandeep K. Chahal, Seamus Caragher, Anthony J. Chalmers, Natividad Gomez-Roman Tags: BIOLOGY CONTRIBUTION Source Type: research

A Randomized Trial Comparing Quality of Life After Low-Dose Rate or High-Dose Rate Prostate Brachytherapy Boost With Pelvic External Beam Radiation Therapy
To compare health-related quality of life (QoL) in urinary, bowel, and sexual domains after combined external beam radiation therapy (EBRT) and either low-dose rate (LDR) or high-dose rate (HDR) prostate brachytherapy (BT). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 15, 2024 Category: Radiology Authors: Juanita Crook, Nikitha Moideen, Greg Arbour, Felipe Castro, Cynthia Araujo, Deidre Batchelar, Ross Halperin, Michelle Hilts, David Kim, David Petrik, Jim Rose, J.C. Cheng, Francois Bachand Tags: CLINICAL INVESTIGATION Source Type: research

ClonoScreen3D – a novel three-dimensional clonogenic screening platform for identification of radiosensitizers for glioblastoma
Glioblastoma (GBM) is a lethal brain tumor. Standard of care treatment comprising surgery, radiation and chemotherapy results in median survival rates of 12-15 months. Molecular targeted agents identified using conventional two-dimensional (2D) in vitro models of GBM have failed to improve outcome in patients, rendering such models inadequate for therapeutic target identification. A previously developed 3D GBM in vitro model that recapitulates key GBM clinical features and responses to molecular therapies was investigated for utility for screening novel radiation-drug combinations using gold-standard clonogenic survival as...
Source: International Journal of Radiation Oncology * Biology * Physics - March 15, 2024 Category: Radiology Authors: Mark R Jackson, Amanda R Richards, Abdul-Basit Ayoola Oladipupo, Sandeep K Chahal, Seamus Caragher, Anthony J Chalmers, Natividad Gomez-Roman Source Type: research

Simultaneous focal boost with stereotactic radiotherapy for localised intermediate to high-risk prostate cancer: Primary outcomes of the SPARC phase II trial
This study evaluated the toxicity and quality of life (QOL) with CyberKnife-based SBRT and simultaneous integrated boost in localised prostate cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 15, 2024 Category: Radiology Authors: Binnaz Yasar, Yae-Eun Suh, Ewan Chapman, Luke Nicholls, Daniel Henderson, Caroline Jones, Kirsty Morrison, Emma Wells, Julia Henderson, Carole Meehan, Aslam Sohaib, Helen Taylor, Alison Tree, Nicholas Van As Tags: Clinical Investigation Source Type: research