International Journal of Radiation Oncology * Biology * Physics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Stereotactic Radiation for Ultra-Central Non-Small Cell Lung Cancer: A Safety and Efficacy Trial (SUNSET)
This study (BLINDED FOR REVIEW) aimed to determine the maximally tolerated dose (MTD) of SBRT for ultra-central (UC) non-small cell lung carcinoma (NSCLC), using a time-to-event continual reassessment methodology (TITE-CRM). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 11, 2024 Category: Radiology Authors: E. Giuliani Meredith, Edith Filion, Sergio Faria, Vijayananda Kundapur, (Toni) Vu Thi Trinh Thuc, Benjamin H. Lok, Srinivas Raman, Houda Bahig, Joanna M. Laba, Pencilla Lang, Alexander V. Louie, Andrew Hope, George B. Rodrigues, Andrea Bezjak, Marie-Pierr Tags: Clinical Investigation Source Type: research

Vestibular Schwannoma International Study of Active Surveillance Versus Stereotactic Radiosurgery: the VISAS Study
The present study assesses the safety and efficacy of stereotactic radiosurgery (SRS) versus observation for Koos grade I and II vestibular schwannoma (VS), benign tumors affecting hearing and neurological function. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 6, 2024 Category: Radiology Authors: Othman Bin-Alamer, Hussam Abou-Al-Shaar, Selcuk Peker, Yavuz Samanci, Isabelle Pelcher, Sabrina Begley, Anuj Goenka, Michael Schulder, Jean-Nicolas Tourigny, David Mathieu, Andr éanne Hamel, Robert G Briggs, Cheng Yu, Gabriel Zada, Steven L Giannotta, He Tags: Clinical Investigation Source Type: research

Stereotactic body radiotherapy combined with lenvatinib with or without PD-1 inhibitors as initial treatment for unresectable hepatocellular carcinoma
The aim of this study was to compare the clinical benefit and safety of the triple combination of stereotactic body radiotherapy (SBRT), lenvatinib and programmed death 1 (PD-1) inhibitors with the dual combination of SBRT and lenvatinib in patients with unresectable hepatocellular carcinoma (uHCC). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 5, 2024 Category: Radiology Authors: Quan Wang, Xiaoquan ji, Jing Sun, Aimin Zhang, Jun Jiaa, Teng Zhang, Wengang Li, Xuezhang Duan Source Type: research

Carotid Artery Stenosis and Ischemic Stroke in Patients with Head and Neck Cancer Treated with Radiotherapy: A Critical Review
The purpose of this review is to summarize the literature on carotid artery stenosis (CAS) and ischemic stroke (IS) in head and neck cancer (HNC) patients treated with radiotherapy (RT) to guide assessment, screening, and management strategies. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 5, 2024 Category: Radiology Authors: Justin Smith, Danielle Margalit, Jonathan Golledge, Domenico Nastasi, Anju Nohria, Lachlan McDowell Tags: Critical Review Source Type: research

Evaluation of radiotherapy treatment plans in a randomized phase II trial comparing two schedules of twice-daily thoracic radiotherapy in limited stage small-cell lung cancer
There is limited clinical data for recommendations on how to deliver thoracic radiotherapy (TRT) concurrently with chemotherapy in limited stage (LS) small-cell lung cancer (SCLC). We reviewed radiotherapy treatment plans in a randomized phase II trial comparing high-dose with standard-dose twice-daily TRT to assess treatment planning techniques, dose-volume data for target volumes and organs at risk (OARs), evaluate compliance with the protocol, associations with radiation-induced toxicity and whether an imbalance in treatment planning parameters might be a reason for the large survival benefit of the higher dose (median ...
Source: International Journal of Radiation Oncology * Biology * Physics - April 5, 2024 Category: Radiology Authors: Nina Levin, Kristin T. Killingberg, Tarje O. Halvorsen, Signe Danielsen, Bj ørn Henning Grønberg Tags: Clinical Investigation Source Type: research

Newly Diagnosed Mental Health Disorders in Patients with Breast Cancer Receiving Radiation Therapy
Patients with a mental health disorder (MHD) have higher age-adjusted mortality compared to the general population. Few reports investigate factors contributing to MHD among breast cancer patients receiving radiotherapy. Here, we report the incidence of acquired MHD after the diagnosis of breast cancer and treatment with radiotherapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 4, 2024 Category: Radiology Authors: Bailey A. Loving, Muayad F. Almahariq, Shaveena Sivapalan, Ronald Levitin, Lihua Qu, Siddharth Ramanathan, Zainab Ijaz, Joshua T. Dilworth Tags: Clinical Investigation Source Type: research

Radiation doses received by major organs at risk in children and young adolescents treated for cancer with external beam radiation therapy: a large-scale study from 12 European countries.
Childhood cancer survivors are at high risk of long-term iatrogenic events, in particular those treated with radiotherapy. The prediction of risk of such events is mainly based on the knowledge of the radiation dose received to healthy organs and tissues during treatment of childhood cancer diagnosed decades ago. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 3, 2024 Category: Radiology Authors: Ibrahima Diallo, Rodrigue S. Allodji, Cristina Veres, St éphanie Bolle, Damien Llanas, Safaa Ezzouhri, Wael Zrafi, Ghazi Debiche, Vincent Souchard, Romain Fauchery, Nadia Haddy, Neige Journy, Charlotte Demoor-Goldschmidt, David L. Winter, Lars Hjorth, Th Tags: Clinical Investigation Source Type: research

Evaluation of a National Radiation Oncology Research and Mentorship Program
This study is an evaluation of the impact of this national research and mentorship award on medical students, resident mentors, and research supervisors over three iterations. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 3, 2024 Category: Radiology Authors: Ruijia Jin, Che Hsuan David Wu, Meredith Giuliani, Corinne Doll, Jolie Ringash, Danny Lavigne, Paris Ann Ingledew Tags: Clinical Investigation Source Type: research

A Pilot Study of Simulation-Free Hippocampal-Avoidance Whole Brain Radiotherapy Using Diagnostic MRI-Based and Online Adaptive Planning
We aimed to demonstrate the clinical feasibility and safety of simulation-free hippocampal avoidance whole brain radiation therapy (HA-WBRT) in a pilot study (NCTXXX). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 3, 2024 Category: Radiology Authors: Kylie H. Kang, Alex T. Price, Francisco J. Reynoso, Eric Laugeman, Eric D. Morris, Pamela P. Samson, Jiayi Huang, Shahed N. Badiyan, Hyun Kim, Randall J. Brenneman, Christopher D. Abraham, Nels C. Knutson, Lauren E. Henke Tags: Brief Report Source Type: research

Clinical Results and Prognostic Factors in BNCT for Recurrent Squamous Cell Carcinoma of the Head and Neck under the Japan National Health Insurance System: A Retrospective Study of the Initial 47 Patients
This study investigates the initial clinical outcomes and prognostic factors associated with BNCT for recurrent squamous cell carcinoma of the head and neck. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 3, 2024 Category: Radiology Authors: Katsumi Hirose, Mariko Sato Tags: Original investigation Source Type: research

Immuno-chemoradiation for non-small cell lung cancer: A meta-analysis of factors influencing survival benefit in combination trials
Adding immune checkpoint blockade (ICB) to concurrent chemoradiotherapy (cCRT) has improved overall survival (OS) for inoperable locally advanced non-small cell lung cancer (LA-NSCLC). Trials of cCRT-ICB are heterogeneous for factors such as tumor stage and histology, PDL1 status and cCRT-ICB schedules. We therefore aimed to determine the ICB contribution to survival across studies and identify factors associated with survival gain. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 1, 2024 Category: Radiology Authors: Huei-Tyng Huang, Douglas H. Brand, John D. Fenwick, Maria A. Hawkins Tags: Clinical Investigation Source Type: research

A Phase II Study Evaluating the Effect of Intensity-Modulated Post-Mastectomy Radiation Therapy on Implant Failure Rates in Breast Cancer Patients with Immediate, 2-Stage Implant Reconstruction, with an MRI imaging correlative substudy
Postmastectomy radiation therapy (PMRT) is a mainstay in the adjuvant treatment of node-positive breast cancer, but it poses risks for women with breast reconstruction. Multi-beam intensity-modulated radiation therapy (IMRT) improves dose conformality and homogeneity, potentially reducing complications in breast cancer patients with implant-based reconstruction. To investigate this hypothesis, we conducted a single-arm phase II clinical trial of breast cancer patients who underwent mastectomy/axillary dissection and prosthesis-based reconstruction. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 1, 2024 Category: Radiology Authors: Atif J. Khan, Catherine B. Marine, Jessica Flynn, Neelam Tyagi, Zhigang Zhang, Maria Thor, Daphna Gelblum, Babak Mehrara, Beryl McCormick, Simon N. Powell, Alice Y. Ho Tags: Clinical Investigation Source Type: research

Safety and efficacy of HL301 in radiation pneumonitis in patients with unresectable non-small cell lung cancer receiving curative concurrent chemoradiotherapy: A multicenter, randomized, double-blinded, placebo-controlled, phase IIa clinical trial
Objective: We aimed to investigate the safety and efficacy of HL301, a standardized combination product of seven medicinal plants, in radiation pneumonitis in patients with unresectable non-small cell lung cancer (NSCLC) undergoing curative concurrent chemoradiotherapy.Methods: The target accrual was 87 and a total of 63 patients were enrolled due to poor accrual rate. We randomly assigned the 63 patients to receive a placebo (arm A), or 1200 mg HL301 (arm B), or 1800 mg HL301 (arm C). Patients received weekly paclitaxel and carboplatin concurrently with intensity-modulated radiotherapy at 60 –66 Gy in conventional fract...
Source: International Journal of Radiation Oncology * Biology * Physics - March 30, 2024 Category: Radiology Authors: Kyung Hwan Kim, Nahyun Kang, Si Yeol Song, Hak Jae Kim, Yeon-Sil Kim, Mi Jin Oh, Jaeho Cho Tags: Brief Report Source Type: research

Predictors of tumour dynamics over a 6-week course of concurrent chemoradiotherapy for glioblastoma and the impact on survival
We present the final analyses of tumour dynamics and their prognostic significance during a 6-week course of concurrent chemoradiotherapy (chemoRT) for glioblastoma (GBM) in the GLIO study. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 30, 2024 Category: Radiology Authors: Wee Loon Ong, James Stewart, Arjun Sahgal, Hany Soliman, Chia-Lin Tseng, Jay Detsky, Hanbo Chen, Ling Ho, Sunit Das, Pejman Maralani, Nir Lipsman, Greg Stanisz, James Perry, Mary Jane Lim-Fat, Eshetu G Atenafu, Angus Lau, Mark Ruschin, Sten Myrehaug Tags: Clinical Investigation Source Type: research

Deep-learning for rapid estimation of the out-of-field dose in external beam photon radiotherapy – A proof of concept
Background and purpose: The dose deposited outside of the treatment field during external photon beam radiotherapy treatment, also known as out-of-field dose, is the subject of extensive study as it may be associated with a higher risk of developing a second cancer, and could have deleterious effects on the immune system which compromise the efficiency of combined radio-immunotherapy treatments. Out-of-field dose estimation tools developed today in research, including Monte Carlo simulations and analytical methods, are not suited to the requirements of clinical implementation because of their lack of versatility and their ...
Source: International Journal of Radiation Oncology * Biology * Physics - March 28, 2024 Category: Radiology Authors: Nathan Benzazon, Alexandre Carr é, François de Kermenguy, Stéphane Niyoteka, Pauline Maury, Julie Colnot, Meissane M'hamdi, Mohammed El Aichi, Cristina Veres, Rodrigue Allodji, Florent de Vathaire, David Sarrut, Neige Journy, Claire Alapetite, Vincent Source Type: research