International Journal of Radiation Oncology * Biology * Physics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Voice Related Quality of Life (qol) in Volumetric Modulated Arc Therapy (vmat) for Non-laryngeal Head and Neck Malignancies
To assess the Voice Quality of life in non-laryngeal carcinoma who undergo VMAT. Primary objective:1.  Subjective assessment of the Voice related QOL in patients undergoing radiation therapy with VMAT technique for non-laryngeal head and neck malignancy using Voice Handicap Index.2. Objective assessment of the Voice related QOL in patients undergoing radiation therapy with VMAT technique for non -laryngeal head and neck malignancy using Video-stroboscopy and voice analysis.Secondary objective:  1. To assess the correlation between Voice related QOL and dose-volume parameters of radiation therapy. (Source: Internati...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: S.K. Ramesh babu, R. Isiah, J. Sargunaraj, R. Thejes, M. Mathew, S. Siddique, S.P. Pavamani, S. John, B.K. Sasidharan, T.B. Peace, S.S. Mathews, R.R.A. Mathews, R. K Tags: 206 Source Type: research

Imaging-based Prognostic Artificial Intelligence Model for Oropharyngeal Carcinoma after Radiation Therapy
This study hypothesizes that pre-treatment CT imaging holds important prognostic information. We developed an artificial intelligence (AI) model to predict locoregional recurrence (LRR) post-radiation therapy (RT) for OPC. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: S. Zhu, M. Gilbert, P. Liu, F. Siddiqui Tags: 207 Source Type: research

Metabolics Underlying Dynamic Optical Contrast Imaging for Head & Neck Cancer Margin Determination
To describe the metabolics underlying cancer and cancer margin detection of lifetime fluorescence in Dynamic Optical Contrast Imaging (DOCI). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: L. Evans, M. Doi, M. Ashendouek, Y.M. Alhiyari, M. St. John Tags: 208 Source Type: research

Enhancing Oral Cancer Diagnosis: A Deep Learning-Based Approach for Malignant Tongue Tumors
Oral cancer, while relatively rare in Korea, is characterized by rapid metastasis and frequent recurrence, making early detection crucial for patient survival and quality of life. If diagnosed late, extensive surgical resection of the malignant tumor can lead to permanent damage throughout the head and neck, severely impacting the patient's quality of life. Consequently, early detection is vital. However, due to its rarity, misdiagnoses are common in general hospitals, potentially leading to treatment delays. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: J.H. Lim, J. Heo, O.K. Noh Tags: 209 Source Type: research

Head and Neck Contour Peer Review Ensures Quality of Radiation Targets
Head and neck (HN) radiotherapy contour quality can directly impact local control (LC) and survival. However, few departments peer review (PR) contours prior to radiotherapy planning (RP). In an effort to improve radiotherapy quality at our institution, we implemented a formal HN contour PR process; this series reports the outcomes of this quality project. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: L.A. McGee, J.C. Rwigema, M. Halyard, T.A. DeWees, J. Gagneur, S.H. Patel Tags: 210 Source Type: research

Deep Learning Based Recurrence Prediction in Head and Neck Cancers after Radiotherapy
Nearly half of patients with head and neck (H&N) cancers experience recurrence, yet the challenge of prognosticating high-risk individuals for intensified radiotherapy persists. Here we aimed to develop a deep learning (DL) model for predicting H&N cancer recurrence based on clinical and radiomic features (texture, shape, intensity) from radiation planning CT simulation scans. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: M.I. Parker, W.W. Su, M. Kang, Y. Yuan, V. Gupta, J.T. Liu, K. Sindhu, E. Genden, R.L. Bakst Tags: 211 Source Type: research

3D Surface Scanning for Virtual CT-Based Electron Beam Treatment Planning in Skin Malignancies of the Head and Neck
Radiation therapy is an important treatment option for skin cancers of the head and neck. Electron beam therapy is a common radiation modality for skin cancer due to its suitability for treating superficial tumors. CT simulation is the gold standard for modeling the 3D characteristics of a patient in electron beam treatment planning. High-resolution 3D surfacing imaging has recently become available for general use. We propose that 3D surface images can be used to generate virtual CT patient models for electron therapy treatment planning. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: D. Harrington, M. Armstrong, D.F. Craft, M.R. Buras, Y. Rong, S.H. Patel Tags: 212 Source Type: research

Radiomic features associated with recurrence in a case:control cohort of surgically treated HPV+ OPSCC
Despite the more favorable prognosis of HPV-associated OPSCC, a subset of these patients are not cured by initial therapy. At presentation, conventional staging and smoking history have poor ability to predict recurrence and survival of the HPV+ OPSCCs undergoing transoral robotic surgery (TORS) followed by pathology-guided adjuvant therapy. In order to enhance prediction of oncologic outcomes under this treatment paradigm, we evaluated a machine learning approach to identify radiomic characteristics that distinguish the patients who subsequently recurred. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: L. Wang, L. Rushkin, S. Patel, Z. Wang, L. Raghav, Y. Tong, J.K. Udupa, D.A. Torigian, D. Basu, L. Sun Tags: 213 Source Type: research

ICG Functionalized Gold Nano Stars Allow for Delivery of Therapeutics and Deep Tumor Imaging Intraoperatively
The primary management of head and neck squamous cell carcinoma relies on complete surgical resection of the tumor, as positive margins are associated with decreased survival. The advantages of radiotherapeutic (RT) dose de-escalation and less aggressive treatments provide better patient quality of life, assuming complete tumor control can still be achieved. The use of gold nanostars (GNS) to accumulate in cancerous tissues via the enhanced permeability and retention (EPR) effect can be employed to localize and treat cancer, offering the potential for enhanced margin delineation and RT dose reduction while still maintainin...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: Y.M. Alhiyari, Y. Liu, L. Mukdad, L. Evans, R. Shori, R. Odion, M. St. John, T. Vo-Dinh Tags: 214 Source Type: research

Improving Treatment Plan Robustness at Internal Tissue-Air Interfaces in Head and Neck Radiotherapy
Volumetric Modulated Arc Therapy (VMAT) has become a staple of modern head and neck (HN) radiation planning, but there may exist unexpected failure modes in which VMAT plans are less robust than typically expected. We identify and characterize one such potential instability (to our knowledge not previously described) that can occur at the interface between target volume (e.g. a mucosal primary tumor) and internal air (e.g. pharyngeal lumen, sinuses, nasal cavity, etc.), where the lack of a sufficient region for full dose buildup can lead to development of unexpected hotspots with even minor variations in target geometry. (...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: S. Jain, A. Ewing, D. Christ, E. Gogineni, M. Weldon, S. Zhu, S.J. Ma, J.C. Grecula, D.L. Mitchell, S. Baliga, D.M. Blakaj, D.J. Konieczkowski Tags: 215 Source Type: research

Patterns of Discordance Between Clinical and Pathologic Stage in Head and Neck Squamous Cell Carcinoma
Like other malignancies, treatment and prognosis of head and neck squamous cell carcinoma is highly dependent on TNM staging. Clinical TN staging (cTN), which is established during the primary workup, helps guide initial treatment but is limited by the quality of physical examination and imaging studies. Pathologic TN staging (pTN) is determined from collected specimens if surgical resection occurs and is considered the gold standard for staging. Previous studies have shown discordance between cTN and pTN, likely due to the limitations of clinical staging. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: N. Punjabi, B. Hondorp, D. Macias, Y. Liu, J. Inman Tags: 216 Source Type: research

Characterization of Heterotopic and Orthotopic Syngeneic MOC1 and MOC2 Tumor Models
MOC1 and MOC2 represent two human papillomavirus (HPV)-negative mouse oral carcinoma (MOC) models commonly used for preclinical studies of head and neck squamous cell carcinoma (HNSCC). While most publications employ subcutaneous heterotopic implantation of these cell lines, orthotopic models are increasingly being used to better recapitulate the tumor microenvironment of human HNSCC. However, the behavior of these tumor models based on location has not been well characterized. Here we present a comparison of time to tumor onset, tumor penetrance, and metastatic potential for MOC1 and MOC2 tumor models in heterotopic (subc...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: A. Rickard, R. Castillo, A. Pittman, K. Gonzales, S. Blocker, X. Shen, P. Clum, J. Everitt, T. Watts, Y.M. Mowery Tags: 217 Source Type: research

Patient-specific 3D CT Images Reconstruction from 2D KV Images
In some proton therapy facilities, patient alignment relies on two 2D orthogonal kV images, taken at fixed, oblique angles, as no 3D on-the-board-imaging is available. The visibility of the tumor in kV images is limited since the patient's 3D anatomy is projected onto a 2D plane, especially when the tumor is behind high-density structures such as bones. This can lead to large patient setup errors. A solution to this problem is to reconstruct the 3D CT image from the kV images obtained at the treatment position. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: Y. Ding, S.H. Patel, J. Holmes, H. Feng, L.A. McGee, J.C. Rwigema, S.A. Vora, W.W. Wong, D.J. Ma, R.L. Foote, B. Li, W. Liu Tags: 218 Source Type: research

Do Spatial-Radiomics Improve Prediction of Locoregional Recurrence Following Radiotherapy for HNSCC?
In this study, we attempt to improve on these models by introducing 2 key innovations. First we identify “supervoxels,” or sub-regions near but outside of the gross tumor volume (GTV), from which to extract radiomic features. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: J. Bae, K.M. Mani, C.J. Noldner, L. Czerwonka, S. Ryu, P. Prasanna Tags: 219 Source Type: research

Radiographic Predictors of Extranodal Extension on Preoperative Contrast-enhanced CT in Patients with Oropharyngeal Squamous Cell Carcinoma
Upfront treatment options for patients with oropharyngeal squamous cell carcinoma (OPSCC) include surgical resection or radiotherapy (RT). In surgically managed patients, extranodal extension (ENE) is an accepted indication for adjuvant chemoRT. Reliable methods to predict ENE using preoperative contrast-enhanced computed tomography (CECT) are needed to better select the initial treatment approach and avoid trimodality therapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: R.T. Hughes, C.M. Lack, J.R. Sachs, K.D. Hiatt, S. Smith, C. Steber, R. D'Agostino, P.M. Bunch Tags: 220 Source Type: research