Potential Role of Lymphocyte CD44 in Determining Treatment Selection Between Stereotactic Body Radiation Therapy and Surgery for Early-Stage Non-Small Cell Lung Cancer
Stereotactic body radiation therapy (SBRT) versus surgery for operable early-stage non-small cell lung cancer (ES-NSCLC) remains highly debated. Herein, we used spatial proteomics to identify whether any molecular biomarker(s) associate with the efficacy of either modality, in efforts to optimize treatment selection between surgery and SBRT for this population. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 4, 2024 Category: Radiology Authors: Weiwei Yan, Ziyuan Ren, Xi Chen, Ran Zhang, Juncai Lv, Vivek Verma, Meng Wu, Dawei Chen, Jinming Yu Tags: Clinical Investigation Source Type: research

Isoform switching regulates the response to ionizing radiation through SRSF1
This study investigates how isoform switching affects the cellular response to ionizing radiation (IR), an understudied area, despite its relevance to radiotherapy in cancer treatment. We aimed to identify changes in transcript isoform expression post-IR exposure and the proteins mediating these changes, with a focus on their potential to modulate radiosensitivity. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 4, 2024 Category: Radiology Authors: Majd Abdulghani, Niema B. Razavian, Joshua T. Burdick, Enric Domingo, Vivian G. Cheung, Timothy C. Humphrey Tags: Biology Contribution Source Type: research

Potential role of lymphocyte CD44 in determining treatment selection between stereotactic body radiotherapy and surgery for early-stage non-small-cell lung cancer
: Stereotactic body radiotherapy (SBRT) versus surgery for operable early-stage non-small-cell lung cancer (ES-NSCLC) remains highly debated. Herein, we utilized spatial proteomics to identify whether any molecular biomarker(s) associate with the efficacy of either modality, in efforts to optimize treatment selection between surgery or SBRT for this population. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 4, 2024 Category: Radiology Authors: Weiwei Yan, Ziyuan Ren, Xi Chen, Ran Zhang, Juncai Lv, Vivek Verma, Meng Wu, Dawei Chen, Jinming Yu Tags: Clinical Investigation Source Type: research

Quantifying regional radiation-induced lung injury in patients using hyperpolarized xenon-129 gas exchange magnetic resonance imaging.
Radiation-induced lung injury (RILI) has been shown to alter regional ventilation and perfusion in the lung. However, changes in regional pulmonary gas exchange have not previously been measured. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 4, 2024 Category: Radiology Authors: Leith J. Rankine, Junlan Lu, Ziyi Wang, Chris R. Kelsey, Lawrence B. Marks, Shiva K. Das, Bastiaan Driehuys Tags: Physics Contribution Source Type: research

Linear Energy Transfer Measurements and Estimation of Relative Biological Effectiveness in Proton and Helium-Ion Beams Using Fluorescent Nuclear Track Detectors
To develop a methodology for assessing the linear energy transfer (LET) and relative biological effectiveness (RBE) in clinical proton and helium-ion beams using fluorescent nuclear track detectors (FNTDs). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 2, 2024 Category: Radiology Authors: Iv án D. Muñoz, Daniel GarcíaCalderón, Renato FelixBautista, Lucas N. Burigo, Jeppe Brage Christensen, Stephan Brons, Armin Runz, Peter Häring, Steffen Greilich, Joao Seco, Oliver Jäkel Tags: Physics Contribution Source Type: research