Commentary on Cost-Effectiveness of Metastasis-Directed Therapy in Oligorecurrent Hormone-Sensitive Prostate Cancer
As the cost of health care rises globally, there is a pressing need to recognize that ever-escalating treatment costs must be matched by improved outcomes; resources spent on care that delivers no benefit may deprive others of beneficial care. As such, we welcome the manuscript by Parikh et  al,1 who seek to estimate the cost-effectiveness of stereotactic radiation therapy for oligometastatic prostate cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 16, 2020 Category: Radiology Authors: Katie L. Spencer, Alison C. Tree Tags: Clinical Investigation Source Type: research

Moving Beyond the Hazard Ratio to Personalized Therapy: Is it Prime Time?
In this issue of the Red Journal, there is an opinion-forming plea for the integration of genomic data into everyday counseling for patients with prostate cancer. The article “Absolute versus relative benefits of Androgen-Deprivation Therapy for Prostate Cancer: Moving beyond the Hazard Ratio to Personalized Therapy” suggests that it is prime time for integrating these tests because they are currently broadly available. However, to date, although scientific evaluatio n has continuously been promoted, it is currently not completed. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 16, 2020 Category: Radiology Authors: Dirk B öhmer, Stefan Höcht, Thomas Wiegel Tags: Clinical Investigation Source Type: research

Evolving Brachytherapy Boost in Prostate Cancer in the Era of Hypofractionation
Radiation therapy (RT) for localized prostate cancer (PCa) has seen a rapid evolution of options to now include conventional fractionation, moderate and ultra-hypofractionation, and brachytherapy (BT) ± supplemental external beam RT (EBRT), in conjunction with risk-based use of androgen deprivation therapy (ADT). This variety gives wide latitude to physicians and patients to select modalities best suited to their preferences, resources, and medical context while achieving largely equitable end r esults. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 16, 2020 Category: Radiology Authors: Neil B. Desai, Aurelie Garant, Raquibul Hannan, Michael R. Folkert Tags: Clinical Investigation Source Type: research

Insights Into Addressing Structural Barriers and Building Specialty Diversity Through a Successful Pipeline Pathway Program
Unique opportunities to effect change to achieve health equity are being presented to the body of medical educators, health care institutions, and specialty associations. Acting on these opportunities entails taking definitive action to address the barriers to achieving health equity nationwide. More specifically, achieving this aspirational goal will require several courageous steps by the medical community, which include, in part (1) acknowledgment of the historical constructs of racism that belie the foundation of health care; (2) analyses of demographic data of the physician workforce and separately that of patients wh...
Source: International Journal of Radiation Oncology * Biology * Physics - October 16, 2020 Category: Radiology Authors: Bonnie S. Mason Tags: The Profession Source Type: research

Issue Highlights
Chino et al (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 16, 2020 Category: Radiology Source Type: research

Meetings
November 10 – 15, 2020 SITC 2020 Virtual (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 16, 2020 Category: Radiology Source Type: research

Ultra-high-dose-rate FLASH and Conventional-Dose-Rate Irradiation Differentially Affect Human Acute Lymphoblastic Leukemia and Normal Hematopoiesis
Ultra-high-dose-rate FLASH radiation therapy has been shown to minimize side effects of irradiation in various organs while keeping antitumor efficacy. This property, called the FLASH effect, has caused enthusiasm in the radiation oncology community because it opens opportunities for safe dose escalation and improved radiation therapy outcome. Here, we investigated the impact of ultra-high-dose-rate FLASH versus conventional-dose-rate (CONV) total body irradiation (TBI) on humanized models of T-cell acute lymphoblastic leukemia (T-ALL) and normal human hematopoiesis. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 16, 2020 Category: Radiology Authors: Sara Chabi, Thi Hong Van To, Ron Leavitt, Sandrine Poglio, Patrik Gon çalves Jorge, Maud Jaccard, Kristoffer Petersson, Benoit Petit, Paul-Henri Roméo, Françoise Pflumio, Marie-Catherine Vozenin, Benjamin Uzan Tags: Biology Contribution Source Type: research

Ultra-high dose rate FLASH and conventional dose rate irradiation differentially affect human acute lymphoblastic leukemia and normal hematopoiesis
Ultra-high dose rate FLASH radiotherapy was shown to minimize side effects of irradiation in various organs while keeping anti-tumor efficacy. This property, called the FLASH effect, causes enthusiasm in radiation oncology community as it opens opportunities for safe dose escalation and improved radiotherapy outcome. Here, we investigated the impact of ultra-high dose rate FLASH vs. conventional dose rate (CONV) total body irradiation (TBI) on humanized models of T cell acute lymphoblastic leukemia (T-ALL) and normal human hematopoiesis. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 16, 2020 Category: Radiology Authors: Sara Chabi, Thi Hong Van To, Ron Leavitt, Sandrine Poglio, Patrik Gon çalves Jorge, Maud Jaccard, Kristoffer Petersson, Benoit Petit, Paul-Henri Roméo, Françoise Pflumio, Marie-Catherine Vozenin, Benjamin Uzan Source Type: research

Safety, Efficacy, and Patterns of Failure After Single-Fraction Stereotactic Body Radiation Therapy (SBRT) for Oligometastases
Fewer attendances for radiation therapy results in increased efficiency and less foot traffic within a radiation therapy department. We investigated outcomes after single-fraction (SF) stereotactic body radiation therapy (SBRT) in patients with oligometastatic disease. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 15, 2020 Category: Radiology Authors: Paolo Sogono, Mathias Bressel, Steven David, Mark Shaw, Sarat Chander, Julie Chu, Nikki Plumridge, Keelan Byrne, Nicholas Hardcastle, Tomas Kron, Greg Wheeler, Gerard G. Hanna, Michael MacManus, David Ball, Shankar Siva Tags: Scientific Letter Source Type: research

Safety, efficacy and patterns of failure after single fraction stereotactic body radiotherapy (SBRT) for oligometastases
Fewer attendances for radiotherapy results in increased efficiency and less foot traffic within a radiotherapy department. We investigated outcomes after single fraction (SF) SBRT in patients with oligometastatic disease. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 15, 2020 Category: Radiology Authors: Paolo Sogono, Mathias Bressel, Steven David, Mark Shaw, Sarat Chander, Julie Chu, Nikki Plumridge, Keelan Byrne, Nick Hardcastle, Tomas Kron, Greg Wheeler, Gerard G. Hanna, Michael MacManus, David Ball, Shankar Siva Source Type: research

Generating High-Quality Lymph Node Clinical Target Volumes for Head and Neck Cancer Radiation Therapy Using a Fully Automated Deep Learning-Based Approach
To develop a deep learning model that generates consistent, high-quality lymph node clinical target volumes (CTV) contours for head and neck cancer (HNC) patients, as an integral part of a fully automated radiation treatment planning workflow. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 14, 2020 Category: Radiology Authors: Carlos E. Cardenas, Beth M. Beadle, Adam S. Garden, Heath D. Skinner, Jinzhong Yang, Dong Joo Rhee, Rachel E. McCarroll, Tucker J. Netherton, Skylar S. Gay, Lifei Zhang, Laurence E. Court Tags: Physics Contribution Source Type: research

Quantitating Interfraction Target Dynamics During Concurrent Chemoradiation for Glioblastoma: A Prospective Serial Imaging Study
This study quantifies interfraction dynamics (tumor size, position, and geometry) based on sequential magnetic resonance imaging scans obtained during standard 6-week chemoradiation. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 14, 2020 Category: Radiology Authors: James Stewart, Arjun Sahgal, Young Lee, Hany Soliman, Chia-Lin Tseng, Jay Detsky, Zain Husain, Ling Ho, Sunit Das, Pejman Jabehdar Maralani, Nir Lipsman, Greg Stanisz, James Perry, Hanbo Chen, Eshetu G. Atenafu, Mikki Campbell, Angus Z. Lau, Mark Ruschin, Tags: Clinical Investigation Source Type: research

Quantitating Inter-fraction Target Dynamics during Concurrent Chemoradiation for Glioblastoma: A Prospective Serial Imaging Study
This study quantifies inter-fraction dynamics (tumor size, position, and geometry) based on sequential MRIs obtained during standard 6 week chemoradiation (CRT). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 14, 2020 Category: Radiology Authors: James Stewart, Arjun Sahgal, Young Lee, Hany Soliman, Chia-Lin Tseng, Jay Detsky, Zain Husain, Ling Ho, Sunit Das, Pejman Jabehdar Maralani, Nir Lipsman, Greg Stanisz, James Perry, Hanbo Chen, Eshetu G. Atenafu, Mikki Campbell, Angus Z. Lau, Mark Ruschin, Source Type: research

Refinement and Validation of the Head and Neck Lymphedema and Fibrosis Symptom Inventory
Lymphedema and fibrosis (LEF) are common yet overlooked late effects of head and neck cancer (HNC) and its therapy. Lack of reliable and valid measures of head and neck LEF is a critical barrier to the timely identification and management of head and neck LEF. To fill in this gap, we developed, and pilot tested a 64-item patient-reported outcome measure (L-survey, abbreviated for purpose of blinding). The article aimed to report the process of further validation and refinement of the tool. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 14, 2020 Category: Radiology Authors: Jie Deng, Mary S. Dietrich, Kenneth J. Niermann, Robert J. Sinard, Anthony J. Cmelak, Sheila H. Ridner, Jill Gilbert, Barbara A. Murphy Source Type: research

Generating High-Quality Lymph Node Clinical Target Volumes for Head and Neck Cancer Radiotherapy Using a Fully Automated Deep Learning-Based Approach
To develop a deep learning model that generates consistent, high-quality lymph node CTV contours for HNC patients, as an integral part of a fully-automated radiation treatment planning workflow. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 14, 2020 Category: Radiology Authors: Carlos E. Cardenas, Beth M. Beadle, Adam S. Garden, Heath D. Skinner, Jinzhong Yang, Dong Joo Rhee, Rachel E. McCarroll, Tucker J. Netherton, Skylar S. Gay, Lifei Zhang, Laurence E. Court Source Type: research

Dose-Volume Effects and Risk Factors for Late Diarrhea in Cervix Cancer Patients after Radiochemotherapy with Image-Guided Adaptive Brachytherapy in the EMBRACE I Study
To evaluate patient- and treatment-related risk factors associated with incidence and persistence of late diarrhea after radiochemotherapy and image-guided adaptive brachytherapy in Locally Advanced Cervical Cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 14, 2020 Category: Radiology Authors: Nina Boje Kibsgaard Jensen, Richard P ötter, Sofia Spampinato, Lars Ulrik Fokdal, Cyrus Chargari, Jacob Christian Lindegaard, Maximilian Schmid, Alina Sturdza, Ina Maria Jürgenliemk-Schulz, Umesh Mahantshetty, Barbara Segedin, Kjersti Bruheim, Peter Hos Source Type: research

RO Model: The Work Continues to Get it Right
(Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 13, 2020 Category: Radiology Authors: Thomas J. Eichler Source Type: research

Phase 1 Study of Low-Dose Fractionated Whole Abdominal Radiation Therapy in Combination With Weekly Paclitaxel for Platinum-Resistant Ovarian Cancer (GCGS-01)
Low-dose fractionated whole abdominal radiation therapy (LDFWART) has synergistic activity with paclitaxel in preclinical models. The aim of this phase 1 trial was to determine the recommended phase 2 dose and preliminary activity of weekly paclitaxel (wP) concurrent with LDFWART in patients with platinum-resistant ovarian cancer (PROC). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 8, 2020 Category: Radiology Authors: Natalie Y.L. Ngoi, Valerie Heong, Johann I. Tang, Bok Ai Choo, Nesaretnam Barr Kumarakulasinghe, Diana Lim, Mellisa Low, Siew Eng Lim, Yi Wan Lim, Yiat Horng Leong, Michelle Tseng, Pearl S.Y. Tong, Arunachalam Ilancheran, Jeffrey J.H. Low, Joseph Ng, Yee Tags: Clinical Investigation Source Type: research

Intensity Modulated Radiation Therapy for Pleural Recurrence of Thymoma: A Prospective Phase 2 Study
This study aimed to evaluate the efficacy and safety of intensity modulated radiation therapy (IMRT) for pleural recurrence of thymoma that was not suitable for surgery and had progressed after chemotherapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 8, 2020 Category: Radiology Authors: Chang-Lu Wang, Lan-Ting Gao, Chang-Xing Lyu, Jia-Ming Wang, Jun Liu, Heng-Le Gu, Yuan Liu, Xiao-Long Fu Tags: Clinical Investigation Source Type: research

Phase I study of low-dose fractionated whole abdominal radiation therapy in combination with weekly paclitaxel for platinum-resistant ovarian cancer (GCGS-01)
Low-dose fractionated whole abdominal radiotherapy (LDFWART) has synergistic activity with paclitaxel in preclinical models. The aim of this phase I trial was to determine the recommended phase 2 dose (RP2D) and preliminary activity of weekly paclitaxel (wP) concurrent with LDFWART in patients with platinum-resistant ovarian cancer (PROC). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 8, 2020 Category: Radiology Authors: Natalie YL. Ngoi, Valerie Heong, Johann I. Tang, Bok Ai Choo, Nesaretnam Barr Kumarakulasinghe, Diana Lim, Mellisa Low BBiomedSc, Siew Eng Lim, Yi Wan Lim, Yiat Horng Leong, Michelle Tseng, Pearl SY. Tong, Arunachalam Ilancheran, Jeffrey JH. Low, Joseph N Source Type: research

Intensity-modulated Radiotherapy for Pleural Recurrence of Thymoma: A Prospective Phase II Study
This study aimed to evaluate the efficacy and safety of intensity-modulated radiotherapy (IMRT) for pleural recurrence of thymoma that was not suitable for surgery and had progressed after chemotherapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 8, 2020 Category: Radiology Authors: Chang-Lu Wang, Lan-Ting Gao, Chang-Xing Lyu, Jia-Ming Wang, Jun Liu, Heng-Le Gu, Yuan Liu, Xiao-Long Fu Source Type: research

Establishment of Microbeam Radiation Therapy at a Small-Animal Irradiator
Microbeam radiation therapy is a preclinical concept in radiation oncology. It spares normal tissue more effectively than conventional radiation therapy at equal tumor control. The radiation field consists of peak regions with doses of several hundred gray, whereas doses between the peaks (valleys) are below the tissue tolerance level. Widths and distances of the beams are in the submillimeter range for microbeam radiation therapy. A similar alternative concept with beam widths and distances in the millimeter range is presented by minibeam radiation therapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 6, 2020 Category: Radiology Authors: Franziska Treibel, Mai Nguyen, Mabroor Ahmed, Annique Dombrowsky, Jan J. Wilkens, Stephanie E. Combs, Thomas E. Schmid, Stefan Bartzsch Tags: Clinical Investigation Source Type: research

Establishment of microbeam radiation therapy at a small animal irradiator
Microbeam radiation therapy (MRT) is a preclinical concept in radiation oncology that spare s normal tissue more effectively than conventional radiation therapy at equal tumour control. The radiation field consists of peak regions with doses of several hundred Gray while doses between the peaks (valleys) are below the tissue tolerance level. Widths and distances of the beams are in the sub-millimeter range for MRT. A similar alternative concept with beam widths and distances in the millimeter range is presented by minibeam radiation therapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 5, 2020 Category: Radiology Authors: Franziska Treibel, Mai Nguyen, Mabroor Ahmed, Annique Dombrowsky, Jan J. Wilkens, Stephanie E. Combs, Thomas E. Schmid, Stefan Bartzsch Tags: Physics Contribution Source Type: research

Pneumonia After Bacterial or Viral Infection Preceded or Followed by Radiation Exposure: A Reanalysis of Older Radiobiologic Data and Implications for Low Dose Radiation Therapy for Coronavirus Disease 2019 Pneumonia
Currently, there are about 15 ongoing clinical studies on low dose radiation therapy for Coronavirus Disease 2019 pneumonia. One of the underlying assumptions is that irradiation of 0.5 to 1.5 Gy is effective at ameliorating viral pneumonia. We aimed to reanalyze all available experimental radiobiologic data to assess evidence for such amelioration. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 30, 2020 Category: Radiology Authors: Mark P. Little, Wei Zhang, Roy van Dusen, Nobuyuki Hamada Tags: Biology Contribution Source Type: research

Pneumonia after bacterial or viral infection preceded or followed by radiation exposure - a reanalysis of older radiobiological data and implications for low dose radiotherapy for COVID-19 pneumonia
Currently, there are about 15 ongoing clinical studies on low dose radiotherapy (LDRT) for COVID-19 pneumonia. One of the underlying assumptions is that irradiation of 0.5 –1.5 Gy is effective at ameliorating viral pneumonia. We aimed to reanalyze all available experimental radiobiological data to assess evidence for such amelioration. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 29, 2020 Category: Radiology Authors: Mark P. Little, Wei Zhang, Roy van Dusen, Nobuyuki Hamada Source Type: research

Positron Emission Tomography Imaging of Functional Transforming Growth Factor β (TGFβ) Activity and Benefit of TGFβ Inhibition in Irradiated Intracranial Tumors
Transforming growth factor β (TGFβ) promotes cell survival by endorsing DNA damage repair and mediates an immunosuppressive tumor microenvironment. Thus, TGFβ activation in response to radiation therapy is potentially targetable because it opposes therapeutic control. Strategies to assess this potential in the clinic are n eeded. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 29, 2020 Category: Radiology Authors: Alba Gonzalez-Junca, Oliver Reiners, Luis D. Borrero-Garcia, Denis Beckford-Vera, Ann A. Lazar, William Chou, Steve Braunstein, Henry VanBrocklin, Benjamin L. Franc, Mary Helen Barcellos-Hoff Tags: Biology Contribution Source Type: research

Health-Related Quality of Life Outcomes in Head and Neck Cancer: Results From a Prospective, Real-World Data Study With Brazilian Patients Treated With Intensity Modulated Radiation Therapy, Conformal and Conventional Radiation Techniques
To compare global health-related quality of life (HRQoL) and overall survival (OS) in patients with head and neck cancer treated with intensity modulated radiation therapy (IMRT), conformal radiation therapy (3DCRT) or conventional radiation therapy (2DRT). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 29, 2020 Category: Radiology Authors: Marcos Santos, Lu ís Felipe Oliveira e Silva, Hugo F. Kohler, Otavio Curioni, Ricardo Vilela, Marcel Fang, Carmen Silvia Passos Lima, João Pedro Gomes, Aline Chaves, Bruno Resende, Karine Trindade, Mauricio Collares, Fernando Obs, Janaina Brollo, Ronald Tags: Clinical Investigation Source Type: research

Positron Emission Tomography Imaging of Functional TGF β Activity and Benefit of TGFβ Inhibition in Irradiated Intracranial Tumors
Transforming growth factor β (TGFβ) promotes cell survival by endorsing DNA damage repair and mediates an immunosuppressive tumor microenvironment. Thus, TGFβ activation in response to radiation therapy is potentially targetable because it opposes therapeutic control. Strategies to assess this potential in the clinic are n eeded. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 28, 2020 Category: Radiology Authors: Alba Gonzalez-Junca, Oliver Reiners, Luis D. Borrero-Garcia, Denis Beckford-Vera, Ann A. Lazar, William Chou, Steve Braunstein, Henry VanBrocklin, Benjamin L. Franc, Mary Helen Barcellos-Hoff Source Type: research

Health-related quality of life outcomes in head and neck cancer: results from a prospective, real world data study with Brazilian patients treated with IMRT, conformal and conventional radiation techniques
To compare global health-related quality of life (HRQoL) and overall survival (OS) in patients with head and neck cancer (HNC) treated with intensity-modulated radiotherapy (IMRT), conformal radiotherapy (3DCRT) or conventional radiotherapy (2DRT). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 28, 2020 Category: Radiology Authors: Marcos Santos, Lu ís Felipe Oliveira e Silva, Hugo F. Kohler, Otavio Curioni, Ricardo Vilela, Marcel Fang, Carmen Silvia Passos Lima, João Pedro Gomes, Aline Chaves, Bruno Resende, Karine Trindade, Mauricio Collares, Fernando Obs, Janaina Brollo, Ronald Source Type: research

Prospective Single-Arm Phase 1 and 2 Study: Ipilimumab and Nivolumab With Thoracic Radiation Therapy After Platinum Chemotherapy in Extensive-Stage Small Cell Lung Cancer
Consolidative thoracic radiation therapy (TRT) has been shown to improve outcomes for patients with extensive stage small cell lung cancer. We hypothesized that the addition of ipilimumab (IPI) and nivolumab (NIVO) after TRT would improve outcomes for patients with extensive stage small cell lung cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 28, 2020 Category: Radiology Authors: Bradford A. Perez, Sungjune Kim, Minhsuan Wang, Ahmad M. Karimi, Chase Powell, Jiannong Li, Thomas J. Dilling, Alberto Chiappori, Kujtim Latifi, Trevor Rose, Austin Lannon, Gretchen MacMillan, James Saller, G. Daniel Grass, Stephen Rosenberg, Jhanelle Gra Tags: Clinical Investigation Source Type: research

Cost-Effectiveness Analysis of Stereotactic Ablative Radiation Therapy in Patients With Oligometastatic Cancer
This study sought to evaluate the cost-effectiveness of the addition of SABR compared with standard therapy alone among cancer patients with oligometastatic disease. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 28, 2020 Category: Radiology Authors: Abhishek Kumar, Christopher Straka, Patrick T. Courtney, Lucas Vitzthum, Paul Riviere, James D. Murphy Tags: Clinical Investigation Source Type: research

High-Resolution pO2 Imaging Improves Quantification of the Hypoxic Fraction in Tumors During Radiation therapy
The extreme microscopic heterogeneity of tumors makes it difficult to characterize tumor hypoxia. We evaluated how changes in the spatial resolution of oxygen imaging could alter measures of tumor hypoxia and their correlation to radiation therapy response. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 28, 2020 Category: Radiology Authors: Xu Cao, Srinivasa Rao Allu, Shudong Jiang, Jason R. Gunn, BS, Cuiping Yao, PhD, Jing Xin, PhD, Petr Bruza, PhD, David J. Gladstone, ScD, Lesley A. Jarvis, MD, PhD, Jie Tian, PhD, Harold M. Swartz, MD, MSPH, PhD, Sergei A. Vinogradov, PhD, Brian W. Pogue, Tags: Clinical Investigation Source Type: research

A Prospective Single Arm Phase I/II Study: Ipilimumab and Nivolumab with Thoracic Radiotherapy after Platinum Chemotherapy in Extensive-Stage Small Cell Lung Cancer
Consolidative thoracic radiotherapy (TRT) has been shown to improve outcomes for patients with extensive stage small cell lung cancer (ES-SCLC). We hypothesized that the addition of ipilimumab (IPI) and nivolumab (NIVO) after TRT would improve outcomes for patients with ES-SCLC. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 27, 2020 Category: Radiology Authors: Bradford A. Perez, Sungjune Kim, Minhsuan Wang, Ahmad M. Karimi, Chase Powell, Jiannong Li, Thomas J. Dilling, Alberto Chiappori, Kujtim Latifi, Trevor Rose, Austin Lannon, Gretchen MacMillan, James Saller, G. Daniel Grass, Stephen Rosenberg, Jhanelle Gra Source Type: research

Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation
and purpose. Identification of appropriate dietary strategies for prevention of weight and muscle loss in cancer patients is crucial for successful treatment and prolonged patient survival. High-protein oral nutritional supplements decrease mortality and improve indices of nutritional status in cancer patients; however, high-protein diets are often rich in methionine, and experimental evidence indicates that a methionine-supplemented diet (MSD) exacerbates gastrointestinal toxicity after total body irradiation (TBI). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 27, 2020 Category: Radiology Authors: Laura E. Ewing, Charles M. Skinner, Rupak Pathak, Eric U. Yee, Kim Krager, Patrick C. Gurley, Stepan Melnyk, Marjan Boerma, Martin Hauer-Jensen, Igor Koturbash Source Type: research

Cost-effectiveness Analysis of Stereotactic Ablative Radiotherapy in Patients with Oligometastatic Cancer
This study sought to evaluate the cost-effectiveness of the addition of SABR compared to standard therapy alone among cancer patients with oligometastatic disease. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 27, 2020 Category: Radiology Authors: Abhishek Kumar, Christopher Straka, Patrick T. Courtney, Lucas Vitzthum, Paul Riviere, James D. Murphy Source Type: research

High Resolution pO2 Imaging Improves Quantification of the Hypoxic Fraction in Tumors during Radiotherapy
The extreme microscopic heterogeneity of tumors makes it difficult to characterize tumor hypoxia. We evaluated how changes in the spatial resolution of oxygen imaging could alter measures of tumor hypoxia and their correlation to radiation therapy response. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 27, 2020 Category: Radiology Authors: Xu Cao, Srinivasa Rao Allu, Shudong Jiang, Jason R. Gunn, Cuiping Yao, Jing Xin, Petr Bruza, David J. Gladstone, Lesley A. Jarvis, Jie Tian, Harold M. Swartz, Sergei A. Vinogradov, Brian W. Pogue Source Type: research

Fully Balanced SSFP Without an Endorectal Coil for Postimplant QA of MRI-Assisted Radiosurgery (MARS) of Prostate Cancer: A Prospective Study
To investigate fully balanced steady-state free precession (bSSFP) with optimized acquisition protocols for magnetic resonance imaging (MRI)-based postimplant quality assessment of low-dose-rate (LDR) prostate brachytherapy without an endorectal coil (ERC). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 24, 2020 Category: Radiology Authors: Jeremiah W. Sanders, Aradhana M. Venkatesan, Chad A. Levitt, Tharakeswara Bathala, Rajat J. Kudchadker, Chad Tang, Teresa L. Bruno, Christine Starks, Edwin Santiago, Michelle Wells, Carl P. Weaver, Jingfei Ma, Steven J. Frank Tags: Physics Contribution Source Type: research

Fully balanced SSFP without an endorectal coil for post-implant QA of MRI-assisted radiosurgery (MARS) of prostate cancer: a prospective study
To investigate fully balanced steady-state free precession (bSSFP) with optimized acquisition protocols for MRI-based post-implant quality assessment of low-dose-rate (LDR) prostate brachytherapy without an endorectal coil (ERC). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 23, 2020 Category: Radiology Authors: Jeremiah W. Sanders, Aradhana M. Venkatesan, Chad A. Levitt, Tharakeswara Bathala, Rajat J. Kudchadker, Chad Tang, Teresa L. Bruno, Christine Starks, Edwin Santiago, Michelle Wells, Carl P. Weaver, Jingfei Ma, Steven J. Frank Tags: Physics Contribution Source Type: research

Reduction of lung metastases in a mouse osteosarcoma model treated with carbon ions and immune checkpoint inhibitors
The combination of radiotherapy and immunotherapy is recognized as a very promising strategy for metastatic cancer treatment. The purpose of this work is to compare the effectiveness of X-ray and high-energy carbon ion therapy in combination with checkpoint inhibitors in a murine model. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 23, 2020 Category: Radiology Authors: Alexander Helm, Walter Tinganelli, Palma Simoniello, Fuki Kurosawa, Claudia Fournier, Takashi Shimokawa, Marco Durante Tags: Biology Contribution Source Type: research

Striking a Chord? Not a Typical Low-Grade Glioma
A 48-year-old male presented with worsening gait instability, blurry vision, headache, and intermittent emesis over a 4-month period. Magnetic resonance imaging of the brain demonstrated a right ventricular mass at the foramen of Monro with associated obstructive hydrocephalus (Fig 1). The lesion was well circumscribed and nonenhancing and measured 1.9 cm × 1.9 cm × 2.1 cm with minimal surrounding edema. A computed tomography scan of the chest/abdomen/pelvis showed no evidence of extracranial disease. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 22, 2020 Category: Radiology Authors: David M. McDermott, Sarah A. Singh Tags: Gray Zone Source Type: research

Typically, We Would Observe
Chordoid glioma, a World Health Organization grade 2 glioma, originates within the intraventricular system and is characterized by its slow growth. Because it displays histopathologic/genetic features distinct from those of other low-grade gliomas,1 it is not representative of other low-grade gliomas reviewed in major randomized clinical trials. Molecularly, it has recently been defined by PRKCA D463H gene mutation with lack of gene alterations in IDH1, IDH2, TP53, ATRX, TERT, MGMT, and 1p19q, and it lacks TSC1 or TSC2 alterations typical of subependymal giant cell astrocytomas. (Source: International Journal of Radiation ...
Source: International Journal of Radiation Oncology * Biology * Physics - September 22, 2020 Category: Radiology Authors: Jonathan M. Sharrett, John H. Suh Tags: Gray Zone Source Type: research

Unique Glioma Requiring Unique Management
The authors present a clinical case of a 48-year-old man who had a gross total resection of a chordoid glioma (CG), World Health Organization (WHO) grade 2, Ki-67 index 3%.1 Although classified as a WHO grade 2 neuroepithelial tumor, CGs, unlike conventional WHO grade 2 gliomas, are noninfiltrative and histologically consist of clusters and cords of epithelioid tumor cells within a mucinous stroma that commonly contains lymphoplasmacytic infiltrate. Extent of surgery has been the only intervention factor consistently associated with outcome. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 22, 2020 Category: Radiology Authors: Caroline Chung Tags: Gray Zone Source Type: research

Radiation for Relapse
This patient had a chordoid glioma at the right ventricle.1 He underwent gross total resection. Neurologic symptoms completely resolved after surgery. A low proliferation index with a Ki-67 of 3% was reported. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 22, 2020 Category: Radiology Authors: Brigitta G. Baumert Tags: Gray Zone Source Type: research

Oligometastasis: Past, Present, Future
In this review, we discuss the oligometastatic state, with a focus on its current and future relevance within the field of radiation therapy. We first outline the scope of the problem and the evolving understanding of metastatic disease existing along a spectrum. We then transition to a discussion of the clinical data that led to the formulation of the oligometastatic hypothesis, delving in some detail into the clinical factors associated with improved outcomes in the setting of local therapy —whether surgical or radiotherapeutic. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 22, 2020 Category: Radiology Authors: Stanley I. Gutiontov, Sean P. Pitroda, Ralph R. Weichselbaum Tags: Clinical Investigation Source Type: research

In Regard to Chou et  al
This study concluded that vulnerability, as measured by comprehensive geriatric assessment (CGA), was independently associated with poorer survival and hig her treatment-related toxicities.1 (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 22, 2020 Category: Radiology Authors: James C.H. Chow, Ka-Man Cheung, Kelvin K.H. Bao, Alex K.C. Leung Tags: Comments Source Type: research

In Reply to Chow et  al
We appreciate the authors for their letter1 highlighting the complex issues of predicting survival and treatment toxicity in patients with head and neck cancer (HNC) before definitive chemoradiation therapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 22, 2020 Category: Radiology Authors: Wen-Chi Chou, Kun-Yun Yeh, Pei-Hung Chang, Chang-Hsien Lu, Yu-Shin Hung, Hung-Ming Wang, Yung-Chang Lin Tags: Comments Source Type: research

It's Time...
No single question in radiation oncology has been investigated as exhaustively as the appropriate fractionation for treating patients with uncomplicated bone metastases. A single fraction of 8 Gy was equivalent to multiple prolonged fractionation schemes in 29 randomized trials and 3 meta-analyses, whether measured by overall response rate, complete response rate, partial response rate, time to pain relief, time to progression of disease, durability of response, development of spinal cord compression, or development of pathologic fracture. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 22, 2020 Category: Radiology Authors: Candice Johnstone, Abram Recht Tags: Clinical Investigation Source Type: research

In Reply to Berk and Alfonso
We thank Drs. Alfonso and Berk for their interest1 in our meta-analysis of outcome data from randomized controlled trials of hypofractionated radiation therapy for low-risk prostate cancer.2 Specifically, we showed how the recently published study of ultrahypofractionated radiation therapy by Widmark et  al3 provides further evidence for a diminishing benefit from radiation therapy intensified by increasing the dose per fraction.2 This is a purely empirical observation and does not rely on any mechanistic assumptions. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 22, 2020 Category: Radiology Authors: Ivan R. Vogelius, S øren M. Bentzen Tags: Comments Source Type: research

Diminishing Returns From Ultrahypofractionated Radiation Therapy for Prostate Cancer In Regard to Vogelius et  al
The recent meta-analysis of the dose-response rate of prostate cancer biochemical control during hypofractionated radiation therapy by Vogelius and Bentzen1 showed that the standard linear-quadratic model was insufficient to model the observed clinical response. They proposed 2 possible corrections: either (1) the slope of the α/β ratio increases by 0.6 for every Gray of increase in the dose per fraction or (2) there is an arbitrary limit to the dose-response curve at 80 Gy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 22, 2020 Category: Radiology Authors: Lawrence Berk, Juan Carlos Lopez Alfonso Tags: Comments Source Type: research

The Red Journal ’s Outstanding Reviewers of 2019
The Red Journal, like most other medical journals, still relies on the dedication and hard work of its peer-reviewers. These individuals, out of a sense of duty to the specialty, give their time, their energy, and their effort to the manuscripts we share with them. Almost all take seriously the dictum to “do unto others as you would wish done to yourself” and read the manuscripts diligently, providing constructive criticism and helping the authors to improve their work, whether it is ultimately published in the Red Journal or not. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 22, 2020 Category: Radiology Authors: Anthony L. Zietman, Sue S. Yom Tags: The Journal Source Type: research