International Journal of Radiation Oncology * Biology * Physics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Phase II Trial of Quality-of-Life Outcomes after Proton Beam for Nasopharyngeal Carcinoma
Radiotherapy is a primary treatment modality for nasopharyngeal cancer (NPC). Advances in radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) have shown less detriment in quality of life (QOL). Proton beam therapy (PBT) has potential to further reduce detriment in QOL due to reduced exposure of normal tissues to low-dose radiation. The purpose of this study was to assess patient-reported QOL outcomes after PBT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: J. Slater, E.A. Weyman, A.W. Chan Tags: 190 Source Type: research

Unraveling the Psychological Burden and Stress Faced by Caregivers of Head and Neck Cancer Patients: A systematic review
The objective of this review is to systematically gather and analyze existing literature, seeking to comprehend the difficulties faced by caregivers, identify the factors that contribute to their psychological burden, and examine the resultant impact on their well-being. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: S. Farsi, S.O. Amole, L. Tong, D. King Tags: 191 Source Type: research

Association Between Frailty and Adverse In-hospital Outcomes after Head and Neck Cancer Surgery Among US Older Adults
The objective of this study was to study the association between frailty and in-hospital complications in a cohort of older adults undergoing head and neck cancer surgery. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: K. Siwakoti, S. Dahal, G.R. Williams, S. Giri Tags: 192 Source Type: research

Brachial Plexus Tolerance To Standard Fractionation Re-irradiation
Head and neck re-irradiation treatment approach can lead to various side effects like radiation induced brachial plexopathy (RIBP). Factors contributing to brachial plexus injury in the re-irradiation setting need further assessment. We aim to identify these factors to help tailor treatment management. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: K. Dibs, E. Gogineni, D.L. Mitchell, D.J. Konieczkowski, S. Baliga, S.R. Jhawar, J.D. Palmer, D.M. Blakaj Tags: 193 Source Type: research

Utility of a Focused Patient Reported Outcome Assessment in a Head and Neck Cancer Radiation Oncology Clinic
Head and neck (HN) radiotherapy (RT) is associated with a substantial acute and late toxicity burden. Patient-reported outcomes (PROs) are critical in understanding the patient's perception of RT toxicity and may provide valuable data points in both clinical trials and the clinic. We sought to evaluate the concordance between clinician rated CTCAE and PRO-CTCAE in HN cancer patients treated with RT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: N. Razavian, R.F. Shenker, R.T. Hughes Tags: 194 Source Type: research

Internal Lymphedema Response to A Single Session of External Advanced Pneumatic Compression in Head and Neck Cancer Survivors
Dysphagia is one of the most significant quality-of-life toxicities reported by individuals with head and neck cancer (HNC) and is ranked as the highest cited reason for decisional regret regarding cancer treatment. Head and neck cancer related lymphedema (HNCRL), both external (subcutaneous) and internal (submucosal), is a common consequence of surgical and non-surgical HNC treatments and has been reported in up to 90% of HNC survivors. Despite this, HNCRL remains significantly underrecognized and undertreated. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: J. Gregor Tags: 195 Source Type: research

A National Comparison of Postoperative Head and Neck Reconstructive Surgery Outcomes in Patients with and Without Immunosuppression
To characterize and assess the effects of immunosuppression on non –head-and-neck-specific postoperative complications following head and neck free flap reconstructive surgery. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: N.C.M. Wang, S.S. Wu, J. Ku, B. Prendes, P. Ciolek, D.J. Genther, E. Lamarre, D. Bottalico Tags: 196 Source Type: research

A Pilot Study of Carotid Ultrasound to Identify Head and Neck Cancer Survivors with High Cardiovascular Risk after Radiation Therapy
Radiotherapy (RT) for head and neck cancer (HNC) is associated with multiple late toxicities and may be a potential driver of accelerated atherosclerosis and a higher risk of carotid artery stenosis (CAS), cerebrovascular and cardiovascular diseases. To date, feasibility, acceptability, and clinical utility of carotid artery ultrasound (CUS) imaging as a part of HNC survivorship has not been studied prospectively. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: R.T. Hughes, C.H. Tegeler, C.L. Nightingale, A.C. Snavely, C.M. Furdui, D.R. Soto-Pantoja, T.C. Register, K.E. Weaver, G.J. Lesser Tags: 197 Source Type: research

Dosimetric Predictors of Clinician-rated and Patient-reported Radiation Dermatitis in Head and Neck Cancer: Exploratory Analysis of a Prospective Pilot Study
There are no well-established dosimetric predictors of clinician-rated acute radiation dermatitis (ARD) in head and neck (HN) radiotherapy (RT). Data regarding the dosimetric associations with patient-reported outcome (PRO) measures of RD are even more scarce. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: R.T. Hughes, B. Levine, B.A. Frizzell, M. Porosnicu, T. Lycan, K.M. Winkfield Tags: 198 Source Type: research

Association of Radiation Dose to Pharynx with Long-term Quality of Life in Patients with Head and Neck Cancer
Radiation therapy (RT) is often the primary curative treatment modality for head and neck cancer (HNC). Patients receiving definitive RT for HNC are at high risk for long-term toxicity, including dry mouth, swallowing difficulties, and speech difficulties. Previous studies have suggested structure sparing during RT planning may reduce treatment toxicity as a way to mitigate these long-term effects. The purpose of this study was to evaluate the association of RT dose to the pharynx, larynx, and esophagus with long-term patient-reported quality of life (QOL) in the domains of xerostomia, dysphagia, and dysarthria. (Source: I...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: M.A. Azam, A. Jhuma, H. Joseph, A.J. Iovoli, A.K. Singh Tags: 199 Source Type: research

Carotid Blowout after Standard Fractionation Re-irradiation: The Ohio State University Experience
Carotid blowout (CB) is a rare but devastating risk for patients (pts) with head and neck cancer. Here, we examined risk of CB among pts treated with conventional fractionation re-irradiation at a single institution. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: K. Dibs, D.J. Konieczkowski, J.D. Palmer, S.R. Jhawar, D.L. Mitchell, E. Gogineni, S. Baliga, M. Old, N. Seim, J.W. Rocco, D.M. Blakaj Tags: 200 Source Type: research

A Review of the Evolution of Quality of Life Measures in Head and Neck Cancer Clinical Trials
To best study the complex toxicity profiles experienced by patients treated with radiotherapy (RT) for head and neck (HN) cancer, a greater focus on quantifiable, reproducible quality of life (QOL) measures is needed. Both clinician-rated outcomes (CRO) and patient-reported outcome (PRO) measures of toxicity and QOL have been collected in HN clinical trials for over two decades. A clear understanding of existing PRO practices in these studies may inform future study design and spark innovative QOL-focused hypothesis-generating research. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: R.T. Hughes, S. Chang, M.T. Truong, S.S. Yom Tags: 201 Source Type: research

Interrogating Frailty as a Predictor of Mortality and Treatment Complications in Older Adults with Oropharyngeal Squamous Cell Carcinoma
As the population continues to age, there will be an increase in human papilloma virus (HPV) associated oropharyngeal carcinomas (OPSCC) in older adults. Frailty is a risk factor for worse disease and survival outcomes in the geriatric population. Biomarkers and frailty indices have been used to quantify and predict survival outcomes and complications. We seek to develop a frailty index using lab abnormalities and comorbidities to predict of mortality and morbidity in older adults with OPSCC. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: D. Vujovic, P. Cooke, M. Miljanic, D.R. Dickstein, E. Genden, M. Posner, S. Roof, W.H. Westra, D. Kirke, K. Misiukiewicz, J.T. Liu, K. Sindhu, V. Gupta, F. Ko, R.L. Bakst Tags: 202 Source Type: research

Functional Outcomes from a Phase II Trial of Adaptive Deescalation of Radiation Therapy Dose in p16+ Oropharyngeal Cancer Patients Demonstrating Favorable Mid-treatment Nodal Response
We report outcomes of patients (pts) with favorable risk p16+ OPC who received deescalated CRT based on mid-treatment (tx) response with rapid mid-tx nodal shrinkage (RMNS) at week 4. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: C. Hung, J.K. Kim, J. Mojica, S. Parody, J.Y. Seo, M. Tam, C. Oh, C.M. Concert, A.E. Vaezi, Z. Li, T. Tran, M. Feron-Rigodon, B. Givi, A. Jacobson, M. Persky, M. Persky, L.B. Harrison, U. Duvvuri, K.S. Hu Tags: 203 Source Type: research

CLIA Validation of a New High Performance HPV ctDNA Assay Covering Multiple High Risk HPV Types
To develop and CLIA validate a droplet digital PCR (ddPCR) assay capable of enhancing the detection of multiple high-risk types of human papillomavirus (hrHPV) circulating tumor DNA (ctDNA) in plasma from patients with HPV-associated oropharyngeal squamous cell carcinoma (HPV+ OPSCC). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: C. Hochfelder, H. Walline, C. Bhambhani, C. Brummel, E. Sandford, R. Akhdar, K. Casper, S.B. Chinn, M.E. Heft-Neal, K. Malloy, J.L. Shah, A. Shuman, M. Spector, C.L. Stucken, F. Worden, M.E. Prince, M.L. Mierzwa, P.L. Swiecicki, M. Tewari, C. Brenner Tags: 204 Source Type: research