Treatment of loco-regional recurrence of nasopharyngeal carcinoma in a non-endemic area: oncologic outcomes, morbidity, and proposal of a prognostic nomogram
ConclusionRecurrent NPC in a non-endemic area has dissimilar aspects compared to its endemic counterpart, suggesting the need for further studies that can guide the choice of the best treatment modality. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - May 16, 2023 Category: Cancer & Oncology Source Type: research
A novel ultra-high dose rate proton therapy technology: spot-scanning proton arc therapy FLASH (SPLASH)
To take full advantage of FLASH dose rate(40Gy/s) and high dose conformity, we introduce a novel optimization and delivery technique, the spot-scanning proton arc therapy(SPArc)+FLASH (SPLASH). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - May 15, 2023 Category: Radiology Authors: Gang Liu, Lewei Zhao, Xiaoqiang Li, Sheng Zhang, Shuyang Dai, Xiliang Lu, Xuanfeng Ding Tags: Physics Contribution Source Type: research
Effect of extended field-of-view approaches on the accuracy of stopping power ratio estimation for single-energy computed tomography simulators
CONCLUSIONS: When an eFOV method is used, the SPR variation in phantoms considerably increases for all TEM rods, especially for lung TEM rods. This phenomenon may substantially increase the uncertainty of HU-to-SPR conversion. Therefore, image reconstruction with a standard FOV size is recommended.PMID:37170691 | DOI:10.1002/acm2.14010 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - May 12, 2023 Category: Physics Authors: Chang-Shiun Lin Yi-Chun Tsai Liang-Hsin Chen Chun-Wei Wang Chia-Jung Wu Wan-Yu Chen Hsiang-Kung Liang Sung-Hsin Kuo Source Type: research
Effect of extended field-of-view approaches on the accuracy of stopping power ratio estimation for single-energy computed tomography simulators
CONCLUSIONS: When an eFOV method is used, the SPR variation in phantoms considerably increases for all TEM rods, especially for lung TEM rods. This phenomenon may substantially increase the uncertainty of HU-to-SPR conversion. Therefore, image reconstruction with a standard FOV size is recommended.PMID:37170691 | DOI:10.1002/acm2.14010 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - May 12, 2023 Category: Cancer & Oncology Authors: Chang-Shiun Lin Yi-Chun Tsai Liang-Hsin Chen Chun-Wei Wang Chia-Jung Wu Wan-Yu Chen Hsiang-Kung Liang Sung-Hsin Kuo Source Type: research
A motion model-guided 4D dose reconstruction for pencil beam scanned proton therapy
We present a novel 4D dose reconstruction method combining delivery log-files with patient-specific motion models, to account for the dosimetric effects of intra- and inter-fractional breathing variability.

Approach. Correlation between an external breathing surrogate and anatomical deformations of the p4DCT is established using principal component analysis. Using motion trajectories of a surface marker acquired during dose delivery by an optical tracking system, deformable motion fields are retrospectively reconstructed and used to generate time-resolved synthetic 4DCTs ('5DCTs') by warping a reference CT...
Source: Physics in Medicine and Biology - May 12, 2023 Category: Physics Authors: Alisha Duetschler Lili Huang Giovanni Fattori Gabriel Meier Christian Bula Jan Hrbacek Sairos Safai Damien Charles Weber Antony John Lomax Ye Zhang Source Type: research
Effect of extended field-of-view approaches on the accuracy of stopping power ratio estimation for single-energy computed tomography simulators
CONCLUSIONS: When an eFOV method is used, the SPR variation in phantoms considerably increases for all TEM rods, especially for lung TEM rods. This phenomenon may substantially increase the uncertainty of HU-to-SPR conversion. Therefore, image reconstruction with a standard FOV size is recommended.PMID:37170691 | DOI:10.1002/acm2.14010 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - May 12, 2023 Category: Physics Authors: Chang-Shiun Lin Yi-Chun Tsai Liang-Hsin Chen Chun-Wei Wang Chia-Jung Wu Wan-Yu Chen Hsiang-Kung Liang Sung-Hsin Kuo Source Type: research
Effect of extended field-of-view approaches on the accuracy of stopping power ratio estimation for single-energy computed tomography simulators
CONCLUSIONS: When an eFOV method is used, the SPR variation in phantoms considerably increases for all TEM rods, especially for lung TEM rods. This phenomenon may substantially increase the uncertainty of HU-to-SPR conversion. Therefore, image reconstruction with a standard FOV size is recommended.PMID:37170691 | DOI:10.1002/acm2.14010 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - May 12, 2023 Category: Cancer & Oncology Authors: Chang-Shiun Lin Yi-Chun Tsai Liang-Hsin Chen Chun-Wei Wang Chia-Jung Wu Wan-Yu Chen Hsiang-Kung Liang Sung-Hsin Kuo Source Type: research
A motion model-guided 4D dose reconstruction for pencil beam scanned proton therapy
We present a novel 4D dose reconstruction method combining delivery log-files with patient-specific motion models, to account for the dosimetric effects of intra- and inter-fractional breathing variability.

Approach. Correlation between an external breathing surrogate and anatomical deformations of the p4DCT is established using principal component analysis. Using motion trajectories of a surface marker acquired during dose delivery by an optical tracking system, deformable motion fields are retrospectively reconstructed and used to generate time-resolved synthetic 4DCTs ('5DCTs') by warping a reference CT...
Source: Physics in Medicine and Biology - May 12, 2023 Category: Physics Authors: Alisha Duetschler Lili Huang Giovanni Fattori Gabriel Meier Christian Bula Jan Hrbacek Sairos Safai Damien Charles Weber Antony John Lomax Ye Zhang Source Type: research
A motion model-guided 4D dose reconstruction for pencil beam scanned proton therapy
We present a novel 4D dose reconstruction method combining delivery log-files with patient-specific motion models, to account for the dosimetric effects of intra- and inter-fractional breathing variability.

Approach. Correlation between an external breathing surrogate and anatomical deformations of the p4DCT is established using principal component analysis. Using motion trajectories of a surface marker acquired during dose delivery by an optical tracking system, deformable motion fields are retrospectively reconstructed and used to generate time-resolved synthetic 4DCTs ('5DCTs') by warping a reference CT...
Source: Physics in Medicine and Biology - May 12, 2023 Category: Physics Authors: Alisha Duetschler Lili Huang Giovanni Fattori Gabriel Meier Christian Bula Jan Hrbacek Sairos Safai Damien Charles Weber Antony John Lomax Ye Zhang Source Type: research
Dosimetric Comparison of Intensity-Modulated Radiation Therapy (IMRT) and Intensity-Modulated Proton Therapy (IMPT) for a Novel Oral Tongue Avoidance Concept in Low-Risk Squamous Cell Carcinoma of the Oral Tongue
CONCLUSION: This study quantifies the feasibility and dosimetric advantages of oral tongue avoidance while still treating the at-risk lymph nodes for oral tongue cancer. The dosimetric difference between PBT and X was most prominent with an oral tongue-avoidance strategy.PMID:37169010 | PMC:PMC10166015 | DOI:10.14338/IJPT-22-00032 (Source: Cancer Control)
Source: Cancer Control - May 11, 2023 Category: Cancer & Oncology Authors: Robert H Press Lei Hu Sheng Huang Shaakir Hasan J Isabelle Choi Charles B Simone Arpit M Chhabra Daphna Y Gelblum Rafi Kabarriti Richard L Bakst Jen R Cracchiolo Sean M McBride Nancy Y Lee Source Type: research
Combined RBE and OER optimization in proton therapy with FLUKA based on EF5-PET
CONCLUSION: The FLUKA MC based tool was able to optimize proton treatment plans taking the tumor pO2 distribution from hypoxia PET images into account. Independent of RBE-model, both elevated LET and physical dose were found in the hypoxic regions, which shows the potential to increase the tumor control compared to a conventional optimization approach.PMID:37161820 | DOI:10.1002/acm2.14014 (Source: Cancer Control)
Source: Cancer Control - May 10, 2023 Category: Cancer & Oncology Authors: Helge Henjum Tordis Johnsen Dahle Andrea Mairani Sara Pilskog Camilla Stokkev åg Camilla Grindeland Boer Kathrine R øe Redalen Heikki Minn Eirik Malinen Kristian Smeland Ytre-Hauge Source Type: research
Combined RBE and OER optimization in proton therapy with FLUKA based on EF5-PET
CONCLUSION: The FLUKA MC based tool was able to optimize proton treatment plans taking the tumor pO2 distribution from hypoxia PET images into account. Independent of RBE-model, both elevated LET and physical dose were found in the hypoxic regions, which shows the potential to increase the tumor control compared to a conventional optimization approach.PMID:37161820 | DOI:10.1002/acm2.14014 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - May 10, 2023 Category: Physics Authors: Helge Henjum Tordis Johnsen Dahle Andrea Mairani Sara Pilskog Camilla Stokkev åg Camilla Grindeland Boer Kathrine R øe Redalen Heikki Minn Eirik Malinen Kristian Smeland Ytre-Hauge Source Type: research
Evaluating the effect of setup uncertainty reduction and adaptation to geometric changes on normal tissue complication probability using online adaptive head and neck intensity modulated proton therapy
Phys Med Biol. 2023 May 10. doi: 10.1088/1361-6560/acd433. Online ahead of print.ABSTRACTTo evaluate the impact of setup uncertainty reduction (SUR) and adaptation to geometrical changes (AGC) on normal tissue complication probability (NTCP) when using online adaptive head and neck intensity modulated proton therapy (IMPT).

Approach: A cohort of ten retrospective head and neck cancer patients with daily scatter corrected cone-beam CT (CBCT) was studied. For each patient, two IMPT treatment plans were created: one with a 3-mm setup uncertainty robustness setting and one with no explicit setup robustness. Bo...
Source: Physics in Medicine and Biology - May 10, 2023 Category: Physics Authors: Arthur Lalonde Mislav Bobic Gregory C Sharp Ibrahim Chamseddine Brian A Winey Harald Paganetti Source Type: research
Double scattering and pencil beam scanning Monte Carlo workflows for proton therapy retrospective studies on radiation-induced toxicities
CONCLUSION: The results demonstrate that the Monte Carlo method can be used to independently validate a TPS calculation, and to estimate LET distributions. The features of the in-house tool can be used to correlate LET and RBE-weighted dose distributions with the incidence of radiation-induced toxicities following proton therapy treatments.PMID:37164897 | DOI:10.1016/j.canrad.2023.02.001 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 10, 2023 Category: Cancer & Oncology Authors: A M M Leite A Bonfrate A Da Fonseca P Lansonneur C Alapetite H Mammar L De Marzi Source Type: research
Evaluating the effect of setup uncertainty reduction and adaptation to geometric changes on normal tissue complication probability using online adaptive head and neck intensity modulated proton therapy
Phys Med Biol. 2023 May 10. doi: 10.1088/1361-6560/acd433. Online ahead of print.ABSTRACTTo evaluate the impact of setup uncertainty reduction (SUR) and adaptation to geometrical changes (AGC) on normal tissue complication probability (NTCP) when using online adaptive head and neck intensity modulated proton therapy (IMPT).

Approach: A cohort of ten retrospective head and neck cancer patients with daily scatter corrected cone-beam CT (CBCT) was studied. For each patient, two IMPT treatment plans were created: one with a 3-mm setup uncertainty robustness setting and one with no explicit setup robustness. Bo...
Source: Physics in Medicine and Biology - May 10, 2023 Category: Physics Authors: Arthur Lalonde Mislav Bobic Gregory C Sharp Ibrahim Chamseddine Brian A Winey Harald Paganetti Source Type: research
