Definitive intensity modulated proton re-irradiation for lung cancer in the immunotherapy era
We report our institutional experience with definitive intent re-irradiation using Intensity Modulated Proton Therapy (IMPT).MethodRetrospective cohort study of recurrent or second primary NSCLC or LS-SCLC treated with IMPT. Kaplan-Meier method and log-rank test were used for time-to-event analyses.Results22 patients were treated from 2019 to 2021. After first course of radiation (median 60 Gy, range 45-70 Gy), 45% received adjuvant immunotherapy. IMPT re-irradiation began a median of 28.2 months (8.8-172.9 months) after initial radiotherapy. The median IMPT dose was 60 GyE (44-60 GyE). 36% received concurrent chemotherapy...
Source: Frontiers in Oncology - January 17, 2023 Category: Cancer & Oncology Source Type: research
Benchmarking of stray neutron fields produced by synchrocyclotrons and synchrotrons in compact protontherapy centers (CPTC) using MCNP6 Monte Carlo code
Appl Radiat Isot. 2022 Dec 31;193:110645. doi: 10.1016/j.apradiso.2022.110645. Online ahead of print.ABSTRACTProton therapy is an external radiotherapy using proton beams with energies between 70 and 230 MeV to treat some type of tumours with outstanding benefits, due to its energy transfer plot. There is a growing demand of facilities taking up small spaces and Compact Proton Therapy Centers (CPTC), with one or two treatment rooms, supposing the technical response of manufacturers to this request. A large amount of stray radiation is yielded in the interaction of proton beam used in therapy, neutrons mainly, hence, optima...
Source: Applied Radiation and Isotopes - January 15, 2023 Category: Radiology Authors: Gonzalo F Garc ía-Fernandez Eduardo Gallego Jos é M Gómez-Ros H éctor R Vega-Carrillo Karen A Guzman-Garc ía Lenin E Cevallos-Robalino Roberto Garc ía-Baonza Eduardo Fuentes Hern ández Source Type: research
Proposing a clinical model for RBE based on proton track-end counts
CONCLUSION: These results suggest that, for clinical optimisation and evaluation, an RBE model based on proton track-end counts may match LETd-based models in terms of information provided, while also offering superior statistical properties.PMID:36642109 | DOI:10.1016/j.ijrobp.2022.12.056 (Source: Health Physics)
Source: Health Physics - January 15, 2023 Category: Physics Authors: Nicholas T Henthorn Lydia L Gardner Adam H Aitkenhead Benjamin C Rowland Jungwook Shin Edward A K Smith Michael J Merchant Ranald I Mackay Karen J Kirkby Pankaj Chaudhary Kevin M Prise Stephen J McMahon Tracy S A Underwood Source Type: research
Benchmarking of stray neutron fields produced by synchrocyclotrons and synchrotrons in compact protontherapy centers (CPTC) using MCNP6 Monte Carlo code
Appl Radiat Isot. 2022 Dec 31;193:110645. doi: 10.1016/j.apradiso.2022.110645. Online ahead of print.ABSTRACTProton therapy is an external radiotherapy using proton beams with energies between 70 and 230 MeV to treat some type of tumours with outstanding benefits, due to its energy transfer plot. There is a growing demand of facilities taking up small spaces and Compact Proton Therapy Centers (CPTC), with one or two treatment rooms, supposing the technical response of manufacturers to this request. A large amount of stray radiation is yielded in the interaction of proton beam used in therapy, neutrons mainly, hence, optima...
Source: Applied Radiation and Isotopes - January 15, 2023 Category: Radiology Authors: Gonzalo F Garc ía-Fernandez Eduardo Gallego Jos é M Gómez-Ros H éctor R Vega-Carrillo Karen A Guzman-Garc ía Lenin E Cevallos-Robalino Roberto Garc ía-Baonza Eduardo Fuentes Hern ández Source Type: research
Cancers, Vol. 15, Pages 516: Costs of Newly Funded Proton Therapy Using Time-Driven Activity-Based Costing in The Netherlands
Conclusion: This study estimated the PT cost delivered in a newly operated treatment center. Scenario analysis for increased patient numbers revealed the potential for cost reductions. Nevertheless, to have an estimation that reflects the matured cost of PT which could be used in cost-effectiveness analysis, a follow-up study assessing the full-fledged situation is recommended. (Source: Cancers)
Source: Cancers - January 14, 2023 Category: Cancer & Oncology Authors: Yi Hsuan Chen Hedwig M. Blommestein Reinder Klazenga Carin Uyl-de Uyl-de Groot Marco van van Vulpen Tags: Article Source Type: research
IMPT of head and neck cancer: unsupervised machine learning treatment planning strategy for reducing radiation dermatitis
In this study, do... (Source: Radiation Oncology)
Source: Radiation Oncology - January 14, 2023 Category: Cancer & Oncology Authors: Noufal Manthala Padannayil, Dayananda Shamurailatpam Sharma, Sapna Nangia, Kartikeshwar C. Patro, Utpal Gaikwad and Nagarjuna Burela Tags: Research Source Type: research
Cancer in pregnancy: treatment effects
ConclusionSpecific considerations and modifications to standard cancer treatments, including surgery and systemic therapies such as chemotherapy, immunotherapy, targeted and hormone therapies are crucial components of providing oncologic care to minimize negative effects to the mother and developing fetus. Radiation and proton therapy are also options that may be employed in specific circumstances. Finally, this article will address the long-term treatment effects of these therapies on future fertility.Graphical Abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - January 13, 2023 Category: Radiology Source Type: research
Study of hepatic toxicity in small liver tumors after photon or proton therapy based on factors predicting the benefits of proton
CONCLUSIONS: The predictive factor numbers predicted the ALBI score change in PBT but not in XRT.ADVANCES IN KNOWLEDGE: This study suggest that the number of predictive factors previously identified (0-1 vs 2-3) were significantly associated with dosimetric parameters of the normal liver in both modalities. In the proton group, the number of predictive factors was associated with a worsening ALBI score at 3 and 6 months, but these associations were not found in the photon SBRT group.PMID:36633335 | DOI:10.1259/bjr.20220720 (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - January 12, 2023 Category: Radiology Authors: Yusuke Uchinami Norio Katoh Daisuke Abo Ryo Morita Hiroshi Taguchi Yoshihiro Fujita Takahiro Kanehira Ryusuke Suzuki Naoki Miyamoto Seishin Takao Taeko Matsuura Takuya Sho Koji Ogawa Tatsuya Orimo Tatsuhiko Kakisaka Keiji Kobashi Hidefumi Aoyama Source Type: research
Single pulse protoacoustic range verification using a clinical synchrocyclotron
Phys Med Biol. 2023 Jan 12. doi: 10.1088/1361-6560/acb2ae. Online ahead of print.ABSTRACTOBJECTIVE: Proton therapy as the next generation radiation-based cancer therapy offers dominant advantages over conventional radiation therapy due to the utilization of the Bragg peak; however, range uncertainty in beam delivery substantially mitigates the advantages of proton therapy. This work reports using protoacoustic measurements to determine the location of proton Bragg peak deposition within a water phantom in real time during beam delivery.APPROACH: In protoacoustics, proton beams have a definitive range, depositing a majority...
Source: Health Physics - January 12, 2023 Category: Physics Authors: Joseph Caron Gilberto Gonzalez Prabodh Kumar Pandey Siqi Wang Kiana Yang Prather Salahuddin Ahmad Liangzhong Xiang Yong Chen Source Type: research
Single pulse protoacoustic range verification using a clinical synchrocyclotron
Phys Med Biol. 2023 Jan 12. doi: 10.1088/1361-6560/acb2ae. Online ahead of print.ABSTRACTOBJECTIVE: Proton therapy as the next generation radiation-based cancer therapy offers dominant advantages over conventional radiation therapy due to the utilization of the Bragg peak; however, range uncertainty in beam delivery substantially mitigates the advantages of proton therapy. This work reports using protoacoustic measurements to determine the location of proton Bragg peak deposition within a water phantom in real time during beam delivery.APPROACH: In protoacoustics, proton beams have a definitive range, depositing a majority...
Source: Physics in Medicine and Biology - January 12, 2023 Category: Physics Authors: Joseph Caron Gilberto Gonzalez Prabodh Kumar Pandey Siqi Wang Kiana Yang Prather Salahuddin Ahmad Liangzhong Xiang Yong Chen Source Type: research
Study of hepatic toxicity in small liver tumors after photon or proton therapy based on factors predicting the benefits of proton
CONCLUSIONS: The predictive factor numbers predicted the ALBI score change in PBT but not in XRT.ADVANCES IN KNOWLEDGE: This study suggest that the number of predictive factors previously identified (0-1 vs 2-3) were significantly associated with dosimetric parameters of the normal liver in both modalities. In the proton group, the number of predictive factors was associated with a worsening ALBI score at 3 and 6 months, but these associations were not found in the photon SBRT group.PMID:36633335 | DOI:10.1259/bjr.20220720 (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - January 12, 2023 Category: Radiology Authors: Yusuke Uchinami Norio Katoh Daisuke Abo Ryo Morita Hiroshi Taguchi Yoshihiro Fujita Takahiro Kanehira Ryusuke Suzuki Naoki Miyamoto Seishin Takao Taeko Matsuura Takuya Sho Koji Ogawa Tatsuya Orimo Tatsuhiko Kakisaka Keiji Kobashi Hidefumi Aoyama Source Type: research
Single pulse protoacoustic range verification using a clinical synchrocyclotron
Phys Med Biol. 2023 Jan 12. doi: 10.1088/1361-6560/acb2ae. Online ahead of print.ABSTRACTOBJECTIVE: Proton therapy as the next generation radiation-based cancer therapy offers dominant advantages over conventional radiation therapy due to the utilization of the Bragg peak; however, range uncertainty in beam delivery substantially mitigates the advantages of proton therapy. This work reports using protoacoustic measurements to determine the location of proton Bragg peak deposition within a water phantom in real time during beam delivery.APPROACH: In protoacoustics, proton beams have a definitive range, depositing a majority...
Source: Health Physics - January 12, 2023 Category: Physics Authors: Joseph Caron Gilberto Gonzalez Prabodh Kumar Pandey Siqi Wang Kiana Yang Prather Salahuddin Ahmad Liangzhong Xiang Yong Chen Source Type: research
Single pulse protoacoustic range verification using a clinical synchrocyclotron
Phys Med Biol. 2023 Jan 12. doi: 10.1088/1361-6560/acb2ae. Online ahead of print.ABSTRACTOBJECTIVE: Proton therapy as the next generation radiation-based cancer therapy offers dominant advantages over conventional radiation therapy due to the utilization of the Bragg peak; however, range uncertainty in beam delivery substantially mitigates the advantages of proton therapy. This work reports using protoacoustic measurements to determine the location of proton Bragg peak deposition within a water phantom in real time during beam delivery.APPROACH: In protoacoustics, proton beams have a definitive range, depositing a majority...
Source: Physics in Medicine and Biology - January 12, 2023 Category: Physics Authors: Joseph Caron Gilberto Gonzalez Prabodh Kumar Pandey Siqi Wang Kiana Yang Prather Salahuddin Ahmad Liangzhong Xiang Yong Chen Source Type: research
Study of hepatic toxicity in small liver tumors after photon or proton therapy based on factors predicting the benefits of proton
CONCLUSIONS: The predictive factor numbers predicted the ALBI score change in PBT but not in XRT.ADVANCES IN KNOWLEDGE: This study suggest that the number of predictive factors previously identified (0-1 vs 2-3) were significantly associated with dosimetric parameters of the normal liver in both modalities. In the proton group, the number of predictive factors was associated with a worsening ALBI score at 3 and 6 months, but these associations were not found in the photon SBRT group.PMID:36633335 | DOI:10.1259/bjr.20220720 (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - January 12, 2023 Category: Radiology Authors: Yusuke Uchinami Norio Katoh Daisuke Abo Ryo Morita Hiroshi Taguchi Yoshihiro Fujita Takahiro Kanehira Ryusuke Suzuki Naoki Miyamoto Seishin Takao Taeko Matsuura Takuya Sho Koji Ogawa Tatsuya Orimo Tatsuhiko Kakisaka Keiji Kobashi Hidefumi Aoyama Source Type: research
Study of hepatic toxicity in small liver tumors after photon or proton therapy based on factors predicting the benefits of proton
CONCLUSIONS: The predictive factor numbers predicted the ALBI score change in PBT but not in XRT.ADVANCES IN KNOWLEDGE: This study suggest that the number of predictive factors previously identified (0-1 vs 2-3) were significantly associated with dosimetric parameters of the normal liver in both modalities. In the proton group, the number of predictive factors was associated with a worsening ALBI score at 3 and 6 months, but these associations were not found in the photon SBRT group.PMID:36633335 | DOI:10.1259/bjr.20220720 (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - January 12, 2023 Category: Radiology Authors: Yusuke Uchinami Norio Katoh Daisuke Abo Ryo Morita Hiroshi Taguchi Yoshihiro Fujita Takahiro Kanehira Ryusuke Suzuki Naoki Miyamoto Seishin Takao Taeko Matsuura Takuya Sho Koji Ogawa Tatsuya Orimo Tatsuhiko Kakisaka Keiji Kobashi Hidefumi Aoyama Source Type: research
