Study of hepatic toxicity in small liver tumors after photon or proton therapy based on factors predicting the benefits of proton
CONCLUSIONS: The predictive factor numbers predicted the ALBI score change in PBT but not in XRT.ADVANCES IN KNOWLEDGE: This study suggest that the number of predictive factors previously identified (0-1 vs 2-3) were significantly associated with dosimetric parameters of the normal liver in both modalities. In the proton group, the number of predictive factors was associated with a worsening ALBI score at 3 and 6 months, but these associations were not found in the photon SBRT group.PMID:36633335 | DOI:10.1259/bjr.20220720 (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - January 12, 2023 Category: Radiology Authors: Yusuke Uchinami Norio Katoh Daisuke Abo Ryo Morita Hiroshi Taguchi Yoshihiro Fujita Takahiro Kanehira Ryusuke Suzuki Naoki Miyamoto Seishin Takao Taeko Matsuura Takuya Sho Koji Ogawa Tatsuya Orimo Tatsuhiko Kakisaka Keiji Kobashi Hidefumi Aoyama Source Type: research
Study of hepatic toxicity in small liver tumors after photon or proton therapy based on factors predicting the benefits of proton
CONCLUSIONS: The predictive factor numbers predicted the ALBI score change in PBT but not in XRT.ADVANCES IN KNOWLEDGE: This study suggest that the number of predictive factors previously identified (0-1 vs 2-3) were significantly associated with dosimetric parameters of the normal liver in both modalities. In the proton group, the number of predictive factors was associated with a worsening ALBI score at 3 and 6 months, but these associations were not found in the photon SBRT group.PMID:36633335 | DOI:10.1259/bjr.20220720 (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - January 12, 2023 Category: Radiology Authors: Yusuke Uchinami Norio Katoh Daisuke Abo Ryo Morita Hiroshi Taguchi Yoshihiro Fujita Takahiro Kanehira Ryusuke Suzuki Naoki Miyamoto Seishin Takao Taeko Matsuura Takuya Sho Koji Ogawa Tatsuya Orimo Tatsuhiko Kakisaka Keiji Kobashi Hidefumi Aoyama Source Type: research
Proposing a clinical model for RBE based on proton track-end counts
In proton therapy, the clinical application of linear energy transfer (LET) optimisation remains contentious, in part due to challenges associated with the definition and calculation of LET and its exact relationship with RBE due to large variation in experimental in vitro data. This has raised interest in other metrics with favourable properties for biological optimisation, such as the number of proton track-ends in a voxel. In this work, we propose a novel model for clinical calculations of RBE, based on proton track-end counts. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 12, 2023 Category: Radiology Authors: Nicholas T. Henthorn, Lydia L. Gardner, Adam H. Aitkenhead, Benjamin C. Rowland, Jungwook Shin, Edward A.K. Smith, Michael J. Merchant, Ranald I. Mackay, Karen J. Kirkby, Pankaj Chaudhary, Kevin M. Prise, Stephen J. McMahon, Tracy S.A. Underwood Source Type: research
Toxicities and Deaths From Intercurrent Disease Following Contemporary Postoperative Radiotherapy in Resected Non-Small-Cell Lung Cancer
CONCLUSION: PORT using contemporary techniques was well tolerated with acceptable toxicity and low rates of intercurrent deaths. Proton therapy significantly reduced heart and lung doses, but radiotherapy modality was not associated with differences in intercurrent disease.PMID:36628846 | DOI:10.1016/j.cllc.2022.12.008 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - January 11, 2023 Category: Cancer & Oncology Authors: Kristine N Kim Jonathan Heintz Nikhil Yegya-Raman Roger Cohen Timothy Kegelman Keith Cengel Melina Marmarelis Lova Sun Corey Langer Charu Aggarwal Aditi Singh Sunil Singhal John Kucharczuk Kyle Robinson Steven Feigenberg Source Type: research
Toxicities and Deaths From Intercurrent Disease Following Contemporary Postoperative Radiotherapy in Resected Non-Small-Cell Lung Cancer
CONCLUSION: PORT using contemporary techniques was well tolerated with acceptable toxicity and low rates of intercurrent deaths. Proton therapy significantly reduced heart and lung doses, but radiotherapy modality was not associated with differences in intercurrent disease.PMID:36628846 | DOI:10.1016/j.cllc.2022.12.008 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - January 11, 2023 Category: Cancer & Oncology Authors: Kristine N Kim Jonathan Heintz Nikhil Yegya-Raman Roger Cohen Timothy Kegelman Keith Cengel Melina Marmarelis Lova Sun Corey Langer Charu Aggarwal Aditi Singh Sunil Singhal John Kucharczuk Kyle Robinson Steven Feigenberg Source Type: research
Initial clinical experience with magnetic resonance-guided radiotherapy in pediatric patients: Lessons learned from a single institution with proton therapy
ConclusionsIn four pediatric patients treated with MRgRT, treatment was well tolerated with no severe acute effects. At our center, most pediatric patients are treated with proton therapy, but the cases selected for MRgRT demonstrated significant organ at risk sparing compared to alternative modalities. In particular, MRgRT may provide advantages for thoracic/abdominal/pelvic targets using gated delivery and adaptive replanning, but selected patients treated with fractionated radiotherapy may also benefit MRgRT through superior organ at risk sparing. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 11, 2023 Category: Cancer & Oncology Source Type: research
An evaluation of the use of DirectSPR images for proton planning in the RayStation treatment planning software
This study showed that SPR maps created by the commercial product from dual-energy CT can successfully be used in RayStation to generate proton dose distributions and that these predictions agree well with measurements.PMID:36625438 | DOI:10.1002/acm2.13900 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - January 10, 2023 Category: Physics Authors: Vikren Sarkar Adam Paxton Fanchi Su Ryan Price Geoff Nelson Martin Szegedi Sara St James Bill J Salter Source Type: research
Dosimetric effects of the supine and prone positions in proton therapy for prostate cancer
Conclusions: We confirmed that the rectal doses were significantly lower in the prone compared with the supine position in PT. Although uncertain, the prone position could be an effective method to reduce the rectal dose in PT. (Source: Journal of Medical Physics)
Source: Journal of Medical Physics - January 10, 2023 Category: Physics Authors: Takahiro Kato Masato Kato Kimihiro Takemasa Masao Murakami Source Type: research
HCC: We Prefer Fractionation Versus Dose Reduction
We recommend ablative doses with proton therapy for most patients with cirrhosis.1 The advantage of improved parenchymal sparing may lower the risk of radiation-induced liver disease and treatment-related liver failure.2 Instead of always giving 5 fractions and reducing the dose to a palliative level for larger volumes, we prefer to combine the technological innovations with the foundational principle of fractionation to deliver ablative doses of radiation therapy (Biologic Equivalent Dose>100 Gy). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 6, 2023 Category: Radiology Authors: Carla Hajj, Christopher H. Crane Tags: Gray Zone Source Type: research
Critical Appraisal of Paediatric Embryonal Cancers Treated with Image-guided Intensity-modulated Proton Therapy
To carry out a comprehensive critical appraisal of image-guided intensity-modulated proton therapy practice for craniospinal irradiation (CSI). (Source: Clinical Oncology)
Source: Clinical Oncology - January 4, 2023 Category: Radiology Authors: D.S. Sharma, N.M. Padanthaiyil, G. Krishnan, M. Arjunan, A.K. Reddy, S. Mahammood, S. Gayen, R. Thiyagarajan, U. Gaikwad, R.T. Sudarsan, S. Chilukuri, R. Jalali Tags: Original Article Source Type: research
TOPAS simulations of the response of a mini-TEPC: benchmark with experimental data
This study aims at the comparison of microdosimetric spectra obtained from both experimental measurements and the microdosimetric extension of TOPAS in the same radiation field.PMID:36595254 | DOI:10.1088/1361-6560/acabfe (Source: Molecular Medicine)
Source: Molecular Medicine - January 3, 2023 Category: Molecular Biology Authors: Anna Bianchi Anna Selva Brigitte Reniers Filip Vanhavere Valeria Conte Source Type: research
Evaluation of treatment planning system accuracy in estimating the stopping-power ratio of immobilization devices for proton therapy
CONCLUSIONS: The TPS tends to underestimate the SPR of selected proton immobilization devices by an average of about 20%, but this does not induce major WET errors because of the low density of the devices. The dosimetric effect of this SPR error was negligible for most treatment sites, although the maximum dose of a few OARs exhibited noticeable variations.PMID:36593751 | DOI:10.1002/acm2.13831 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - January 3, 2023 Category: Physics Authors: Kai Jiang Michael MacFarlane Sina Mossahebi Mark J Zakhary Source Type: research
TOPAS simulations of the response of a mini-TEPC: benchmark with experimental data
This study aims at the comparison of microdosimetric spectra obtained from both experimental measurements and the microdosimetric extension of TOPAS in the same radiation field.PMID:36595254 | DOI:10.1088/1361-6560/acabfe (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - January 3, 2023 Category: Physics Authors: Anna Bianchi Anna Selva Brigitte Reniers Filip Vanhavere Valeria Conte Source Type: research
TOPAS simulations of the response of a mini-TEPC: benchmark with experimental data
This study aims at the comparison of microdosimetric spectra obtained from both experimental measurements and the microdosimetric extension of TOPAS in the same radiation field.PMID:36595254 | DOI:10.1088/1361-6560/acabfe (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - January 3, 2023 Category: Physics Authors: Anna Bianchi Anna Selva Brigitte Reniers Filip Vanhavere Valeria Conte Source Type: research
Evaluation of treatment planning system accuracy in estimating the stopping-power ratio of immobilization devices for proton therapy
CONCLUSIONS: The TPS tends to underestimate the SPR of selected proton immobilization devices by an average of about 20%, but this does not induce major WET errors because of the low density of the devices. The dosimetric effect of this SPR error was negligible for most treatment sites, although the maximum dose of a few OARs exhibited noticeable variations.PMID:36593751 | DOI:10.1002/acm2.13831 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - January 3, 2023 Category: Physics Authors: Kai Jiang Michael MacFarlane Sina Mossahebi Mark J Zakhary Source Type: research
