Deterioration of Visual Acuity after Brachytherapy and Proton Therapy of Uveal Melanoma, and Methods of Counteracting This Complication Based on Recent Publications
This article is a review of the latest research on ruthenium-106 (Ru-106) brachytherapy, iodine-125 (I-125) brachytherapy and proton therapy of uveal melanoma that took into account the deterioration of eye function after therapy, and also the latest studies presenting the new concepts of modifications to the applied treatments in order to reduce radiation complications and maintain better visual acuity in treated patients.PMID:37374335 | PMC:PMC10303310 | DOI:10.3390/medicina59061131 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 28, 2023 Category: Universities & Medical Training Authors: Jakub Jarczak Izabella Karska-Basta Bo żena Romanowska-Dixon Source Type: research

Deterioration of Visual Acuity after Brachytherapy and Proton Therapy of Uveal Melanoma, and Methods of Counteracting This Complication Based on Recent Publications
This article is a review of the latest research on ruthenium-106 (Ru-106) brachytherapy, iodine-125 (I-125) brachytherapy and proton therapy of uveal melanoma that took into account the deterioration of eye function after therapy, and also the latest studies presenting the new concepts of modifications to the applied treatments in order to reduce radiation complications and maintain better visual acuity in treated patients.PMID:37374335 | PMC:PMC10303310 | DOI:10.3390/medicina59061131 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 28, 2023 Category: Universities & Medical Training Authors: Jakub Jarczak Izabella Karska-Basta Bo żena Romanowska-Dixon Source Type: research

Deterioration of Visual Acuity after Brachytherapy and Proton Therapy of Uveal Melanoma, and Methods of Counteracting This Complication Based on Recent Publications
This article is a review of the latest research on ruthenium-106 (Ru-106) brachytherapy, iodine-125 (I-125) brachytherapy and proton therapy of uveal melanoma that took into account the deterioration of eye function after therapy, and also the latest studies presenting the new concepts of modifications to the applied treatments in order to reduce radiation complications and maintain better visual acuity in treated patients.PMID:37374335 | PMC:PMC10303310 | DOI:10.3390/medicina59061131 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 28, 2023 Category: Universities & Medical Training Authors: Jakub Jarczak Izabella Karska-Basta Bo żena Romanowska-Dixon Source Type: research

Deterioration of Visual Acuity after Brachytherapy and Proton Therapy of Uveal Melanoma, and Methods of Counteracting This Complication Based on Recent Publications
This article is a review of the latest research on ruthenium-106 (Ru-106) brachytherapy, iodine-125 (I-125) brachytherapy and proton therapy of uveal melanoma that took into account the deterioration of eye function after therapy, and also the latest studies presenting the new concepts of modifications to the applied treatments in order to reduce radiation complications and maintain better visual acuity in treated patients.PMID:37374335 | PMC:PMC10303310 | DOI:10.3390/medicina59061131 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 28, 2023 Category: Universities & Medical Training Authors: Jakub Jarczak Izabella Karska-Basta Bo żena Romanowska-Dixon Source Type: research

Deterioration of Visual Acuity after Brachytherapy and Proton Therapy of Uveal Melanoma, and Methods of Counteracting This Complication Based on Recent Publications
This article is a review of the latest research on ruthenium-106 (Ru-106) brachytherapy, iodine-125 (I-125) brachytherapy and proton therapy of uveal melanoma that took into account the deterioration of eye function after therapy, and also the latest studies presenting the new concepts of modifications to the applied treatments in order to reduce radiation complications and maintain better visual acuity in treated patients.PMID:37374335 | PMC:PMC10303310 | DOI:10.3390/medicina59061131 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 28, 2023 Category: Universities & Medical Training Authors: Jakub Jarczak Izabella Karska-Basta Bo żena Romanowska-Dixon Source Type: research

In silico comparison of whole pelvis intensity-modulated photon versus proton therapy for the postoperative management of prostate cancer
CONCLUSION: IMPT provides comparable target coverage to IMRT when treating prostate cancer with WPRT in the postoperative setting while significantly reducing dose to OARs. These data can inform the future clinical management and delivery of post-prostatectomy irradiation for prostate cancer.PMID:37345868 | DOI:10.1080/0284186X.2023.2224925 (Source: Acta Oncologica)
Source: Acta Oncologica - June 22, 2023 Category: Cancer & Oncology Authors: Emile Gogineni Ian K Cruickshank Hao Chen Aditya Halthore Heng Li Curtiland Deville Source Type: research

Influence of the background in Compton camera images for proton therapy treatment monitoring
Phys Med Biol. 2023 Jun 20. doi: 10.1088/1361-6560/ace024. Online ahead of print.ABSTRACTOBJECTIVE: Background events are one of the most relevant contributions to image degradation in Compton camera imaging for hadron therapy treatment monitoring. A study of the background and its contribution to image degradation is important to define future strategies to reduce the background in the system.APPROACH: In this simulation study, the percentage of different kinds of events and their contribution to the reconstructed image in a two-layer Compton camera have been evaluated. To this end, GATE v8.2 simulations of a proton beam ...
Source: Physics in Medicine and Biology - June 20, 2023 Category: Physics Authors: Marina Borja-Lloret Luis Barrientos Jos é Bernabéu Alberola Carlos Lacasta Enrique Mu ñoz Ana Ros Jorge Roser Rita Viegas Gabriela Llosa Source Type: research

Influence of the background in Compton camera images for proton therapy treatment monitoring
Phys Med Biol. 2023 Jun 20. doi: 10.1088/1361-6560/ace024. Online ahead of print.ABSTRACTOBJECTIVE: Background events are one of the most relevant contributions to image degradation in Compton camera imaging for hadron therapy treatment monitoring. A study of the background and its contribution to image degradation is important to define future strategies to reduce the background in the system.APPROACH: In this simulation study, the percentage of different kinds of events and their contribution to the reconstructed image in a two-layer Compton camera have been evaluated. To this end, GATE v8.2 simulations of a proton beam ...
Source: Physics in Medicine and Biology - June 20, 2023 Category: Physics Authors: Marina Borja-Lloret Luis Barrientos Jos é Bernabéu Alberola Carlos Lacasta Enrique Mu ñoz Ana Ros Jorge Roser Rita Viegas Gabriela Llosa Source Type: research

Prediction of plan adaptation in head and neck cancer proton therapy using clinical, radiographic, and dosimetric features
CONCLUSION: There are several dosimetric and clinical features that correlate to re-plans, and NNs trained with these features can be used to predict HN re-plans, which can be used to reduce re-plan rate by improving plan quality.PMID:37335043 | DOI:10.1080/0284186X.2023.2224050 (Source: Acta Oncologica)
Source: Acta Oncologica - June 19, 2023 Category: Cancer & Oncology Authors: D Bohannon J Janopaul-Naylor S Rudra X Yang C W Chang Y Wang C Ma S A Patel M W McDonald J Zhou Source Type: research

Surface Chemistry and Specific Surface Area rule the Efficiency of Gold Nanoparticle Sensitizers in Proton Therapy
Chemistry. 2023 Jun 19:e202301260. doi: 10.1002/chem.202301260. Online ahead of print.ABSTRACTGold nanoparticles (AuNPs) are known radiosensitizers in proton therapy (PT) applicable for the treatment of solid tumors, where they amplify production of reactive oxygen species (ROS). However, it is underexplored how this amplification is correlated with the AuNPs´ surface chemistry. To clarify this issue, we fabricated ligand-free AuNPs of different mean diameters by laser ablation in liquids (LAL) and laser fragmentation in liquids (LFL) and irradiated them with clinically relevant proton fields using water phantoms. ROS gen...
Source: Chemistry - June 19, 2023 Category: Chemistry Authors: Jacob Johny Charlotte E R van Halteren Fatih-Can Cakir Sandra Zwiehoff Carina Behrends Christian B äumer Beate Timmermann Laur èl Rauschenbach Stephan Tippelt Bj örn Scheffler Alexander Schramm Christoph Rehbock Stephan Barcikowski Source Type: research

Prediction of plan adaptation in head and neck cancer proton therapy using clinical, radiographic, and dosimetric features
CONCLUSION: There are several dosimetric and clinical features that correlate to re-plans, and NNs trained with these features can be used to predict HN re-plans, which can be used to reduce re-plan rate by improving plan quality.PMID:37335043 | DOI:10.1080/0284186X.2023.2224050 (Source: Acta Oncologica)
Source: Acta Oncologica - June 19, 2023 Category: Cancer & Oncology Authors: D Bohannon J Janopaul-Naylor S Rudra X Yang C W Chang Y Wang C Ma S A Patel M W McDonald J Zhou Source Type: research

Surface Chemistry and Specific Surface Area rule the Efficiency of Gold Nanoparticle Sensitizers in Proton Therapy
Chemistry. 2023 Jun 19:e202301260. doi: 10.1002/chem.202301260. Online ahead of print.ABSTRACTGold nanoparticles (AuNPs) are known radiosensitizers in proton therapy (PT) applicable for the treatment of solid tumors, where they amplify production of reactive oxygen species (ROS). However, it is underexplored how this amplification is correlated with the AuNPs´ surface chemistry. To clarify this issue, we fabricated ligand-free AuNPs of different mean diameters by laser ablation in liquids (LAL) and laser fragmentation in liquids (LFL) and irradiated them with clinically relevant proton fields using water phantoms. ROS gen...
Source: Chemistry - June 19, 2023 Category: Chemistry Authors: Jacob Johny Charlotte E R van Halteren Fatih-Can Cakir Sandra Zwiehoff Carina Behrends Christian B äumer Beate Timmermann Laur èl Rauschenbach Stephan Tippelt Bj örn Scheffler Alexander Schramm Christoph Rehbock Stephan Barcikowski Source Type: research

High-speed low-noise optical respiratory monitoring for spot scanning proton therapy
CONCLUSIONS: The investigated optical respiratory sensor was found to be appropriate to use in surface guided spot scanning proton therapy. This sensor combined with a fast respiratory signal processing algorithm may provide accurate beam control and a fast response in patients' irregular breathing movements. A careful study of correlation between the respiratory signal and 4DCT data of tumor position will be required before clinical implementation.PMID:37329740 | DOI:10.1016/j.ejmp.2023.102612 (Source: Cancer Control)
Source: Cancer Control - June 17, 2023 Category: Cancer & Oncology Authors: Mikhail Belikhin Alexander Pryanichnikov Vladimir Balakin Alexander Shemyakov Pavel Zhogolev Alexander Chernyaev Source Type: research

Osteoradionecrosis and Proton Therapy
To the Editor We have several comments about the recent study that found a 10.6% prevalence of osteoradionecrosis (ORN) among patients with head and neck cancer receiving proton radiation therapy (PRT). (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - June 15, 2023 Category: ENT & OMF Source Type: research

Osteoradionecrosis and Proton Therapy —Reply
In Reply Thank you for your interest in our recent publication on osteoradionecrosis (ORN) of the jaw following proton radiation therapy (PRT) for head and neck cancer. We provide below the response to your comments. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - June 15, 2023 Category: ENT & OMF Source Type: research