Variable RBE in proton radiotherapy: a comparative study with the predictive Mayo Clinic Florida microdosimetric kinetic model and phenomenological models of cell survival
Phys Med Biol. 2023 Dec 22;68(18). doi: 10.1088/1361-6560/acf43b.ABSTRACTObjectives. (1) To examine to what extent the cell- and exposure- specific information neglected in the phenomenological proton relative biological effectiveness (RBE) models could influence the computed RBE in proton therapy. (2) To explore similarities and differences in the formalism and the results between the linear energy transfer (LET)-based phenomenological proton RBE models and the microdosimetry-based Mayo Clinic Florida microdosimetric kinetic model (MCF MKM). (3) To investigate how the relationship between the RBE and the dose-mean proton ...
Source: Physics in Medicine and Biology - December 22, 2023 Category: Physics Authors: Alessio Parisi Chris J Beltran Keith M Furutani Source Type: research

Variable RBE in proton radiotherapy: a comparative study with the predictive Mayo Clinic Florida microdosimetric kinetic model and phenomenological models of cell survival
Phys Med Biol. 2023 Dec 22;68(18). doi: 10.1088/1361-6560/acf43b.ABSTRACTObjectives. (1) To examine to what extent the cell- and exposure- specific information neglected in the phenomenological proton relative biological effectiveness (RBE) models could influence the computed RBE in proton therapy. (2) To explore similarities and differences in the formalism and the results between the linear energy transfer (LET)-based phenomenological proton RBE models and the microdosimetry-based Mayo Clinic Florida microdosimetric kinetic model (MCF MKM). (3) To investigate how the relationship between the RBE and the dose-mean proton ...
Source: Physics in Medicine and Biology - December 22, 2023 Category: Physics Authors: Alessio Parisi Chris J Beltran Keith M Furutani Source Type: research

Variable RBE in proton radiotherapy: a comparative study with the predictive Mayo Clinic Florida microdosimetric kinetic model and phenomenological models of cell survival
Phys Med Biol. 2023 Dec 22;68(18). doi: 10.1088/1361-6560/acf43b.ABSTRACTObjectives. (1) To examine to what extent the cell- and exposure- specific information neglected in the phenomenological proton relative biological effectiveness (RBE) models could influence the computed RBE in proton therapy. (2) To explore similarities and differences in the formalism and the results between the linear energy transfer (LET)-based phenomenological proton RBE models and the microdosimetry-based Mayo Clinic Florida microdosimetric kinetic model (MCF MKM). (3) To investigate how the relationship between the RBE and the dose-mean proton ...
Source: Physics in Medicine and Biology - December 22, 2023 Category: Physics Authors: Alessio Parisi Chris J Beltran Keith M Furutani Source Type: research

Variable RBE in proton radiotherapy: a comparative study with the predictive Mayo Clinic Florida microdosimetric kinetic model and phenomenological models of cell survival
Phys Med Biol. 2023 Dec 22;68(18). doi: 10.1088/1361-6560/acf43b.ABSTRACTObjectives. (1) To examine to what extent the cell- and exposure- specific information neglected in the phenomenological proton relative biological effectiveness (RBE) models could influence the computed RBE in proton therapy. (2) To explore similarities and differences in the formalism and the results between the linear energy transfer (LET)-based phenomenological proton RBE models and the microdosimetry-based Mayo Clinic Florida microdosimetric kinetic model (MCF MKM). (3) To investigate how the relationship between the RBE and the dose-mean proton ...
Source: Physics in Medicine and Biology - December 22, 2023 Category: Physics Authors: Alessio Parisi Chris J Beltran Keith M Furutani Source Type: research

Technical note: Implementing MRI/CT-based elemental concentration data to Monte Carlo simulation for yielding positron emitters in proton therapy
CONCLUSION: At least in the head area, the MRWC/CT method demonstrated potential for more precise predictions of proton-induced positron emitter distributions via MC simulations than that of the CT-only method.PMID:38116829 | DOI:10.1002/mp.16896 (Source: Health Physics)
Source: Health Physics - December 20, 2023 Category: Physics Authors: Masatoshi Saito Ryuga Matsumoto Source Type: research

Technical note: Implementing MRI/CT-based elemental concentration data to Monte Carlo simulation for yielding positron emitters in proton therapy
CONCLUSION: At least in the head area, the MRWC/CT method demonstrated potential for more precise predictions of proton-induced positron emitter distributions via MC simulations than that of the CT-only method.PMID:38116829 | DOI:10.1002/mp.16896 (Source: Health Physics)
Source: Health Physics - December 20, 2023 Category: Physics Authors: Masatoshi Saito Ryuga Matsumoto Source Type: research

Ten-year experience with intracameral chemotherapy for aqueous seeding in retinoblastoma: long-term efficacy, safety and toxicity
Conclusion ICC appears to be safe and efficient for AS without irreversible vision-threatening adverse effects. More data are needed to determine any superiority in efficiency/toxicity of topotecan versus melphalan. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Stathopoulos, C., Beck-Popovic, M., Moulin, A. P., Munier, F. L. Tags: Open access Oncology Source Type: research

Uncertainty-aware MR-based CT synthesis for robust proton therapy planning of brain tumour
CONCLUSION: The enhanced framework incorporates 3D uncertainty prediction and generates high-quality sCTs from MR images. The framework also facilitates conditioned robust optimisation, bolstering proton plan robustness against network prediction errors. The innovative feature of uncertainty visualisation and robust analyses contribute to evaluating sCT clinical utility for individual patients.PMID:38104781 | DOI:10.1016/j.radonc.2023.110056 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 17, 2023 Category: Radiology Authors: Xia Li Renato Bellotti Gabriel Meier Barbara Bachtiary Damien Weber Antony Lomax Joachim Buhmann Ye Zhang Source Type: research

Editorial for the proton therapy special issue
Hello Medical Dosimetry/Radiation Oncology Colleagues, (Source: Medical Dosimetry)
Source: Medical Dosimetry - December 16, 2023 Category: Radiology Authors: Stacey Schmidt Source Type: research

Oxygen supplementation in anesthesia can block FLASH effect and anti-tumor immunity in conventional proton therapy
CONCLUSIONS: These results demonstrate the need to further optimize anesthesia protocols used in radiotherapy with the goal of preserving normal tissues and achieving tumor control, specifically in combination with immunotherapy agents.PMID:38102219 | DOI:10.1038/s43856-023-00411-9 (Source: Cancer Control)
Source: Cancer Control - December 15, 2023 Category: Cancer & Oncology Authors: Lorea Iturri Anna ïg Bertho Charlotte Lamirault Elise Brisebard Marjorie Juchaux Crist èle Gilbert Julie Espenon Catherine S ébrié Laur ène Jourdain Ludovic de Marzi Fr édéric Pouzoulet Jane Muret Pierre Verrelle Yolanda Prezado Source Type: research

A novel inverse algorithm to solve IPO-IMPT of proton FLASH therapy with sparse filters
Purpose:The recently proposed Integrated Physical Optimization Intensity Modulated Proton Therapy (IPO-IMPT) framework allows simultaneous optimization of dose, dose rate, and linear energy transfer (LET) for FLASH treatment planning. Finding solutions to IPO-IMPT is difficult due to computational intensiveness. Nevertheless, an inverse solution that simultaneously specifies the geometry of a sparse filter and weights of a proton intensity map is desirable for both clinical and preclinical applications. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - December 15, 2023 Category: Radiology Authors: Nathan Harrison, Minglei Kang, Ruirui Liu, Serdar Charyyev, Niklas Wahl, Wei Liu, Jun Zhou, Kristin A. Higgins, Charles B. Simone, Jeffrey D. Bradley, William S. Dynan, Liyong Lin Tags: Physics Contribution Source Type: research

A Novel Inverse Algorithm To Solve the Integrated Optimization of Dose, Dose Rate, and Linear Energy Transfer of Proton FLASH Therapy With Sparse Filters
The recently proposed Integrated Physical Optimization Intensity Modulated Proton Therapy (IPO-IMPT) framework allows simultaneous optimization of dose, dose rate, and linear energy transfer (LET) for ultra-high dose rate (FLASH) treatment planning. Finding solutions to IPO-IMPT is difficult because of computational intensiveness. Nevertheless, an inverse solution that simultaneously specifies the geometry of a sparse filter and weights of a proton intensity map is desirable for both clinical and preclinical applications. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - December 15, 2023 Category: Radiology Authors: Nathan Harrison, Minglei Kang, Ruirui Liu, Serdar Charyyev, Niklas Wahl, Wei Liu, Jun Zhou, Kristin A. Higgins, Charles B. Simone, Jeffrey D. Bradley, William S. Dynan, Liyong Lin Tags: PHYSICS CONTRIBUTION Source Type: research

Anatomical changes in resection cavity during brain radiotherapy
ConclusionRCs are dynamic after surgery. Potentially, an additional margin in brain cancer patients with an RC should be considered, to avoid insufficient target coverage. Future research on local recurrence patterns is recommended. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 14, 2023 Category: Cancer & Oncology Source Type: research

Uncertainty-aware MR-based CT synthesis for robust proton therapy planning of brain tumour
Proton therapy, a state-of-the-art technology in radiotherapy, is garnering increasing attention. Its exceptional characteristic of high-dose conformity underscores the critical importance of accurately representing the patient's geometry in proton therapy planning. Consequently, obtaining the most up-to-date geometric model of the patient through frequent daily imaging is essential to harness the full potential of proton physics. Meanwhile, MR-based radiotherapy has emerged as an auspicious approach, marked by the commercialization of the MR-Linac technology and its active clinical implementation. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - December 14, 2023 Category: Radiology Authors: Xia Li, Renato Bellotti, Gabriel Meier, Barbara Bachtiary, Damien Weber, Antony Lomax, Joachim Buhmann, Ye Zhang Tags: Original Article Source Type: research

Deep learning-based synthetic dose-weighted LET map generation for intensity modulated proton therapy
Phys Med Biol. 2023 Dec 13. doi: 10.1088/1361-6560/ad154b. Online ahead of print.ABSTRACTThe advantage of proton therapy as compared to photon therapy stems from the Bragg peak effect, which allows protons to deposit most of their energy directly at the tumor while sparing healthy tissue. However, even with such benefits, proton therapy does present certain challenges. The biological effectiveness differences between protons and photons are not fully incorporated into clinical treatment planning processes. In current clinical practice, the relative biological effectiveness (RBE) between protons and photons is set as consta...
Source: Physics in Medicine and Biology - December 13, 2023 Category: Physics Authors: Yuan Gao Chih-Wei Chang Shaoyan Pan Junbo Peng Chaoqiong Ma Pretesh Patel Justin Roper Jun Zhou Xiaofeng Yang Source Type: research