Neurocognitive outcomes in pediatric brain tumors after treatment with proton versus photon radiation: a systematic review and meta-analysis
CONCLUSIONS: Pediatric brain tumor patients who receive PBRT achieve significantly higher scores on most neurocognitive outcomes than those who receive XRT. Larger studies with long-term follow-ups are needed to confirm these results.PMID:37154861 | DOI:10.1007/s12519-023-00726-6 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 8, 2023 Category: Pediatrics Authors: Álvaro Lassaletta Javier S Morales Pedro L Valenzuela Borja Esteso Lisa S Kahalley Donald J Mabbott Soumya Unnikrishnan Elena Panizo Felipe Calvo Source Type: research
Neurocognitive outcomes in pediatric brain tumors after treatment with proton versus photon radiation: a systematic review and meta-analysis
CONCLUSIONS: Pediatric brain tumor patients who receive PBRT achieve significantly higher scores on most neurocognitive outcomes than those who receive XRT. Larger studies with long-term follow-ups are needed to confirm these results.PMID:37154861 | DOI:10.1007/s12519-023-00726-6 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 8, 2023 Category: Pediatrics Authors: Álvaro Lassaletta Javier S Morales Pedro L Valenzuela Borja Esteso Lisa S Kahalley Donald J Mabbott Soumya Unnikrishnan Elena Panizo Felipe Calvo Source Type: research
Detectability of anatomical changes with prompt-gamma imaging: First systematic evaluation of clinical application during prostate-cancer proton therapy
The development of online-adaptive proton therapy (PT) is an essential requirement to overcome limitations encountered by day-to-day variations of the patient anatomy. Range verification could play an essential role in an online feedback loop for the detection of treatment deviations such as anatomical changes. Here, we present results of the first systematic patient study regarding the detectability of anatomical changes by a prompt-gamma imaging (PGI) slit-camera system. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - May 7, 2023 Category: Radiology Authors: Jonathan Berthold, Julian Pietsch, Nick Piplack, Chirasak Khamfongkhruea, Julia Thiele, Tobias H ölscher, Guillaume Janssens, Julien Smeets, Erik Traneus, Steffen Löck, Kristin Stützer, Christian Richter Tags: Physics Contribution Source Type: research
Proton therapy for pediatric diencephalic tumors
Diencephalic tumors tend to be low grade tumors located near several critical structures, including the optic nerves, optic chiasm, pituitary, hypothalamus, Circle of Willis, and hippocampi. In children, damage to these structures can impact physical and cognitive development over time. Thus, the goal of radiotherapy is to maximize long term survival while minimizing late effects, including endocrine disruption leading to precocious puberty, height loss, hypogonadotropic hypogonadism, and primary amenorrhea; visual disruption including blindness; and vascular damage resulting in cerebral vasculopathy. Compared to photon th...
Source: Frontiers in Oncology - May 5, 2023 Category: Cancer & Oncology Source Type: research
Patient selection for proton therapy using Normal Tissue Complication Probability with deep learning dose prediction for oropharyngeal cancer
CONCLUSIONS: AI-PROTIPP shows that using DL dose prediction in combination with NTCP models to select PT for patients is feasible and can help to save time by avoiding the generation of treatment plans only used for the comparison. Moreover, DL models are transferable, allowing, in the future, experience to be shared with centers that would not have PT planning expertise.PMID:37140481 | DOI:10.1002/mp.16431 (Source: Health Physics)
Source: Health Physics - May 4, 2023 Category: Physics Authors: Margerie Huet-Dastarac Steven Michiels Sara Teruel Rivas Hamdiye Ozan Edmond Sterpin John A Lee Ana Barragan-Montero Source Type: research
The first PET glimpse of a proton FLASH beam
Phys Med Biol. 2023 May 4. doi: 10.1088/1361-6560/acd29e. Online ahead of print.ABSTRACTWe demonstrate the first ever recorded PET imaging and dosimetry of a FLASH proton beam at the Proton Center of the MD~Anderson Cancer Center.
Two scintillating LYSO crystal arrays, read out by silicon photomultipliers, were configured with a partial field of view of a~cylindrical PMMA phantom irradiated by a FLASH proton beam. The proton beam had a kinetic energy of 75.8\,MeV and an intensity of about $3.5\times10^{10}$ protons that were extracted over 101.5\,ms-long spills. The radiation environment was characterized by CZT an...
Source: Physics in Medicine and Biology - May 4, 2023 Category: Physics Authors: Firas Abouzahr John Paul Cesar Paulo Crespo Michael Julius Gajda Zongsheng Hu Willie Kaye Kyle Klein Alex Kuo Stanislaw Majewski Osama R Mawlawi Andrey Morozov Aryan Ojha Falk Poenisch Jerimy C Polf Marek Proga Narayan Sahoo Joao Seco Takeshi Takaoka Stef Source Type: research
The first PET glimpse of a proton FLASH beam
Phys Med Biol. 2023 May 4. doi: 10.1088/1361-6560/acd29e. Online ahead of print.ABSTRACTWe demonstrate the first ever recorded PET imaging and dosimetry of a FLASH proton beam at the Proton Center of the MD~Anderson Cancer Center.
Two scintillating LYSO crystal arrays, read out by silicon photomultipliers, were configured with a partial field of view of a~cylindrical PMMA phantom irradiated by a FLASH proton beam. The proton beam had a kinetic energy of 75.8\,MeV and an intensity of about $3.5\times10^{10}$ protons that were extracted over 101.5\,ms-long spills. The radiation environment was characterized by CZT an...
Source: Physics in Medicine and Biology - May 4, 2023 Category: Physics Authors: Firas Abouzahr John Paul Cesar Paulo Crespo Michael Julius Gajda Zongsheng Hu Willie Kaye Kyle Klein Alex Kuo Stanislaw Majewski Osama R Mawlawi Andrey Morozov Aryan Ojha Falk Poenisch Jerimy C Polf Marek Proga Narayan Sahoo Joao Seco Takeshi Takaoka Stef Source Type: research
The first PET glimpse of a proton FLASH beam
Phys Med Biol. 2023 May 4. doi: 10.1088/1361-6560/acd29e. Online ahead of print.ABSTRACTWe demonstrate the first ever recorded PET imaging and dosimetry of a FLASH proton beam at the Proton Center of the MD~Anderson Cancer Center.
Two scintillating LYSO crystal arrays, read out by silicon photomultipliers, were configured with a partial field of view of a~cylindrical PMMA phantom irradiated by a FLASH proton beam. The proton beam had a kinetic energy of 75.8\,MeV and an intensity of about $3.5\times10^{10}$ protons that were extracted over 101.5\,ms-long spills. The radiation environment was characterized by CZT an...
Source: Physics in Medicine and Biology - May 4, 2023 Category: Physics Authors: Firas Abouzahr John Paul Cesar Paulo Crespo Michael Julius Gajda Zongsheng Hu Willie Kaye Kyle Klein Alex Kuo Stanislaw Majewski Osama R Mawlawi Andrey Morozov Aryan Ojha Falk Poenisch Jerimy C Polf Marek Proga Narayan Sahoo Joao Seco Takeshi Takaoka Stef Source Type: research
The first PET glimpse of a proton FLASH beam
Phys Med Biol. 2023 May 4. doi: 10.1088/1361-6560/acd29e. Online ahead of print.ABSTRACTWe demonstrate the first ever recorded PET imaging and dosimetry of a FLASH proton beam at the Proton Center of the MD~Anderson Cancer Center.
Two scintillating LYSO crystal arrays, read out by silicon photomultipliers, were configured with a partial field of view of a~cylindrical PMMA phantom irradiated by a FLASH proton beam. The proton beam had a kinetic energy of 75.8\,MeV and an intensity of about $3.5\times10^{10}$ protons that were extracted over 101.5\,ms-long spills. The radiation environment was characterized by CZT an...
Source: Physics in Medicine and Biology - May 4, 2023 Category: Physics Authors: Firas Abouzahr John Paul Cesar Paulo Crespo Michael Julius Gajda Zongsheng Hu Willie Kaye Kyle Klein Alex Kuo Stanislaw Majewski Osama R Mawlawi Andrey Morozov Aryan Ojha Falk Poenisch Jerimy C Polf Marek Proga Narayan Sahoo Joao Seco Takeshi Takaoka Stef Source Type: research
The first PET glimpse of a proton FLASH beam
Phys Med Biol. 2023 May 4. doi: 10.1088/1361-6560/acd29e. Online ahead of print.ABSTRACTWe demonstrate the first ever recorded PET imaging and dosimetry of a FLASH proton beam at the Proton Center of the MD~Anderson Cancer Center.
Two scintillating LYSO crystal arrays, read out by silicon photomultipliers, were configured with a partial field of view of a~cylindrical PMMA phantom irradiated by a FLASH proton beam. The proton beam had a kinetic energy of 75.8\,MeV and an intensity of about $3.5\times10^{10}$ protons that were extracted over 101.5\,ms-long spills. The radiation environment was characterized by CZT an...
Source: Physics in Medicine and Biology - May 4, 2023 Category: Physics Authors: Firas Abouzahr John Paul Cesar Paulo Crespo Michael Julius Gajda Zongsheng Hu Willie Kaye Kyle Klein Alex Kuo Stanislaw Majewski Osama R Mawlawi Andrey Morozov Aryan Ojha Falk Poenisch Jerimy C Polf Marek Proga Narayan Sahoo Joao Seco Takeshi Takaoka Stef Source Type: research
Analytical modeling and Monte Carlo simulations of multi-parallel slit and knife-edge slit prompt gamma cameras
Conclusion: The MPS camera outperforms the KES camera with their design specifications in realistic conditions and both systems can reach millimetric precision in the determination of the falloff position with 108 or more initial protons.PMID:37137315 | DOI:10.1088/1361-6560/acd237 (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - May 3, 2023 Category: Physics Authors: Brent Huisman Enrique Mu ñoz Denis Dauvergne Jean Michel L étang David Sarrut Etienne Testa Source Type: research
Clinical results of proton beam radiotherapy for inoperable stage III non-small cell lung cancer: a Japanese national registry study
This study presents the first data of a Japanese nationwide multi-institutional cohort and compares them with the findings of systematic literature reviews on radiation therapies and inoperable stage III non-small cell lung cancer (NSCLC) conducted by the Lung Cancer Working Group in the Particle Beam Therapy (PBT) Committee and Subcommittee at Japanese Society for Radiation Oncology. The Lung Cancer Working Group extracted eight reports and compared their data with those of the PBT registry from May 2016 to June 2018. All the analyzed 75 patients aged ≤80 years underwent proton therapy (PT) with concurrent chemotherapy ...
Source: Cell Research - May 3, 2023 Category: Cytology Authors: Hitoshi Tatebe Hideyuki Harada Keita Mori Hiromitsu Iwata Tetsuo Akimoto Masao Murakami Takahiro Waki Takashi Ogino Masatoshi Nakamura Hiroshi Taguchi Haruhiko Nakayama Miyako Satouchi Hidefumi Aoyama Source Type: research
Analytical modeling and Monte Carlo simulations of multi-parallel slit and knife-edge slit prompt gamma cameras
Conclusion: The MPS camera outperforms the KES camera with their design specifications in realistic conditions and both systems can reach millimetric precision in the determination of the falloff position with 108 or more initial protons.PMID:37137315 | DOI:10.1088/1361-6560/acd237 (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - May 3, 2023 Category: Physics Authors: Brent Huisman Enrique Mu ñoz Denis Dauvergne Jean Michel L étang David Sarrut Etienne Testa Source Type: research
Clinical outcome after pencil beam scanning proton therapy and dysphagia/xerostomia NTCP calculations of proton and photon radiotherapy delivered to patients with cancer of the major salivary glands
CONCLUSION: Our data suggest excellent oncological outcome and low late toxicity rates for patients with SGT treated with PBSPT. NTCP calculation showed a substantial risk reduction for Grade 2 or 3 xerostomia and dysphagia in some SGT patients, while for others, no clear benefit was seen with protons, suggesting that comparative planning should be performed routinely for these patients.ADVANCES IN KNOWLEDGE: We have reported that the clinical outcome of SGT patients treated with PT and compared IMPT to VMAT for the treatment of salivary gland tumour and have observed that protons delivered significantly less dose to organ...
Source: The British Journal of Radiology - May 2, 2023 Category: Radiology Authors: Marc Andrea Walser Nicolas Bachmann Jonas Kluckert A K öthe Carson Tully Dominic Leiser Antony John Lomax Nicola Bizzocchi Johannes Albertus Langendijk Damien C Weber Source Type: research
Clinical outcome after pencil beam scanning proton therapy and dysphagia/xerostomia NTCP calculations of proton and photon radiotherapy delivered to patients with cancer of the major salivary glands
CONCLUSION: Our data suggest excellent oncological outcome and low late toxicity rates for patients with SGT treated with PBSPT. NTCP calculation showed a substantial risk reduction for Grade 2 or 3 xerostomia and dysphagia in some SGT patients, while for others, no clear benefit was seen with protons, suggesting that comparative planning should be performed routinely for these patients.ADVANCES IN KNOWLEDGE: We have reported that the clinical outcome of SGT patients treated with PT and compared IMPT to VMAT for the treatment of salivary gland tumour and have observed that protons delivered significantly less dose to organ...
Source: Cancer Control - May 2, 2023 Category: Cancer & Oncology Authors: Marc Andrea Walser Nicolas Bachmann Jonas Kluckert A K öthe Carson Tully Dominic Leiser Antony John Lomax Nicola Bizzocchi Johannes Albertus Langendijk Damien C Weber Source Type: research
