The impact of motion on onboard MRI-guided pencil beam scanned proton therapy treatments
Phys Med Biol. 2024 Mar 27. doi: 10.1088/1361-6560/ad3885. Online ahead of print.ABSTRACTOnline magnetic resonance imaging (MRI) guidance could be especially beneficial for pencil beam scanned (PBS) proton therapy of tumours affected by respiratory motion. For the first time to our knowledge, we investigate the dosimetric impact of respiratory motion on MRI-guided proton therapy compared to the scenario without magnetic field.

Approach. A previously developed analytical proton dose calculation algorithm accounting for perpendicular magnetic fields was extended to enable 4D dose calculations. For two geomet...
Source: Physics in Medicine and Biology - March 27, 2024 Category: Physics Authors: Alisha Duetschler Sairos Safai Damien Charles Weber Antony John Lomax Ye Zhang Source Type: research
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Phys Med Biol. 2024 Mar 27. doi: 10.1088/1361-6560/ad3887. Online ahead of print.ABSTRACTThe in vivo evolution of radiotherapy necessitates innovative platforms for preclinical investigation, bridging the gap between bench research and clinical applications. Understanding the nuances of radiation response, specifically tailored to proton and photon therapies, is critical for optimizing treatment outcomes. Within this context, preclinical in vivo experimental setups incorporating image guidance for both photon and proton therapies are pivotal, enabling the translation of findings from small animal models to clinical setting...
Source: Physics in Medicine and Biology - March 27, 2024 Category: Physics Authors: Moritz Schneider Joshua Dietrich Schilz Michael Sch ürer Sebastian Gantz Anne Dreyer Gert Rothe Falk Tillner Elisabeth Bodenstein Felix Horst Elke Beyreuther Source Type: research
Impact of iodinated oil in proton therapy on relative stopping power of liver post-cTACE
Phys Med Biol. 2024 Mar 27. doi: 10.1088/1361-6560/ad388b. Online ahead of print.ABSTRACTConventional transarterial chemoembolization (cTACE) is a common treatment for hepatocellular carcinoma (HCC), often with unsatisfactory local controls. Combining cTACE with radiotherapy shows a promise for unresectable large HCC, with proton therapy preserving healthy liver tissue. However, the proton therapy benefits are subject to the accuracy of tissue relative stopping power (RSP) prediction. The RSP values are typically derived from computed tomography (CT) images using stoichiometric calibration. Lipiodol deposition significantl...
Source: Physics in Medicine and Biology - March 27, 2024 Category: Physics Authors: Jiong Shu Jianguang Zhang Kyung-Wook Jee Ling Ling Liu Man Hu Wanli Huo Xiangli Cui Hongzhi Wang Hsiao-Ming Lu Source Type: research
Sensors, Vol. 24, Pages 2137: High-Density Glass Scintillators for Proton Radiography & mdash;Relative Luminosity, Proton Response, and Spatial Resolution
Sensors, Vol. 24, Pages 2137: High-Density Glass Scintillators for Proton Radiography—Relative Luminosity, Proton Response, and Spatial Resolution
Sensors doi: 10.3390/s24072137
Authors:
Ethan Stolen
Ryan Fullarton
Rain Hein
Robin L. Conner
Luiz G. Jacobsohn
Charles-Antoine Collins-Fekete
Sam Beddar
Ugur Akgun
Daniel Robertson
Proton radiography is a promising development in proton therapy, and researchers are currently exploring optimal detector materials to construct proton radiography detector arrays. High-density glass scintillators may improve integrating-mode proton radiography detec...
Source: Sensors - March 27, 2024 Category: Biotechnology Authors: Ethan Stolen Ryan Fullarton Rain Hein Robin L. Conner Luiz G. Jacobsohn Charles-Antoine Collins-Fekete Sam Beddar Ugur Akgun Daniel Robertson Tags: Article Source Type: research
An updated variable RBE model for proton therapy
In this study, an updatedin vitroproton RBE database was collected and used to examine current RBE model assumptions, and to propose an up-to-date RBE model as a tool for evaluating RBE effects in clinical settings. 
Approach.A proton database (471 data points) was collected from the literature, almost twice the size of the previously largest model database. Each data point included linear-quadratic model parameters and linear energy transfer (LET). Statistical analyses were performed to test the validity of commonly applied assumptions of phenomenological RBE models, and new model functions were proposed for RBEma...
Source: Physics in Medicine and Biology - March 25, 2024 Category: Physics Authors: Erlend Lyngholm Camilla Hanqvuist Stokkev åg Armin L ühr Liheng Tian Ilker Meric Johannes Tjelta Helge Henjum Andreas Havsg ård Handeland Kristian Smeland Ytre-Hauge Source Type: research
Prospective evaluation of patient-reported outcomes of invisible ink tattoos for the delivery of external beam radiation therapy: the PREFER trial
DiscussionIn the largest prospective trial on IIT-based radiotherapy setup to date, we found that patients prefer IITs to VITs. Additionally, IIT-based alignment is an effective and efficient strategy in comparison with tattooless setup. Standard incorporation of IITs for patient setup should be strongly considered. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research
Response to the letter by Boon and colleagues
We appreciate the letter by Boon and colleagues[1], highlighting a number of points important for studies of head and neck cancer in general and proton therapy in particularly. The varied approaches adopted in the current four randomized trials, alongside the non-randomized model-based selection in the Netherlands, underscore the variation of relevant endpoints of toxicity, which is, by definition, multifaceted[2]. We believe that the diversity in approach may actually be a strength, particularly if these studies can be analysed together at a later stage. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - March 25, 2024 Category: Radiology Authors: J. Friborg, K. Jensen, C. Grau, C.R. Hansen Tags: Letter to the Editor Source Type: research
Study on induced radioactivity and individual dose evaluation in Gantry room for Varian ProBeam Proton Therapy System
This study focuses on systematically investigating the induced radioactivity in the gantry room during pencil beam scanning, utilizing both experimental measurements and Monte Carlo simulations. Results indicate that patients are the primary source of induced radioactivity, predominantly producing radionuclides such as 11C, 13N, and 15O. Long-term irradiation primarily generates radionuclides like 22Na, 24Na, and 54Mn etc. Additionally, this study estimates the individual doses received by medical workers in the gantry room, the irradiation dose for patient escorts, and the additional dose to patients from residual radiati...
Source: Applied Radiation and Isotopes - March 21, 2024 Category: Radiology Authors: Changli Luo Wuyuan Li Yang Li Xilong Han Bo Yang Youwu Su Shakhboz Khasanov Xuebo Liu Wang Mao Weiwei Yan Source Type: research
Study on induced radioactivity and individual dose evaluation in Gantry room for Varian ProBeam Proton Therapy System
This study focuses on systematically investigating the induced radioactivity in the gantry room during pencil beam scanning, utilizing both experimental measurements and Monte Carlo simulations. Results indicate that patients are the primary source of induced radioactivity, predominantly producing radionuclides such as 11C, 13N, and 15O. Long-term irradiation primarily generates radionuclides like 22Na, 24Na, and 54Mn etc. Additionally, this study estimates the individual doses received by medical workers in the gantry room, the irradiation dose for patient escorts, and the additional dose to patients from residual radiati...
Source: Applied Radiation and Isotopes - March 21, 2024 Category: Radiology Authors: Changli Luo Wuyuan Li Yang Li Xilong Han Bo Yang Youwu Su Shakhboz Khasanov Xuebo Liu Wang Mao Weiwei Yan Source Type: research
Changes in Radiation Therapy: New Ultrahypofractionated Radiation, Repeat Breast Conservation Therapy in the Management of Breast Recurrence with Re-irradiation, Proton Therapy
AbstractPurpose of ReviewManagement of breast cancer is multidisciplinary, balancing local and systemic control between treatment modalities. Surgical, radiation, and medical therapies are combined to give the best prognosis. The goal of this review is to examine the advancements in radiotherapy in the treatment of breast cancer.Recent FindingsPublished data supports the shortening of radiation schedules through ultrahypofractionation and utilizing new energy sources through proton beam radiation. Emerging techniques have minimized radiation dosage to organs at risk and skin when compared to traditional radiation sources a...
Source: Current Breast Cancer Reports - March 21, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1217: Longitudinal Assessment of Quality of Life in Nasopharyngeal Cancer Patients Treated with Intensity-Modulated Proton Therapy and Volumetric Modulated Arc Therapy at Different Time Points
Conclusions: Compared to VMAT, dose reduction attributed to IMPT could translate into better functional QoL and HN35 symptoms, but the effect is time dependent and exclusively observed during the RT phase. (Source: Cancers)
Source: Cancers - March 20, 2024 Category: Cancer & Oncology Authors: Kuan-Cho Liao Yu-Jie Huang Wen-Ling Tsai Chien-Hung Lee Fu-Min Fang Tags: Article Source Type: research
An Analysis of PET Maximum SUV Among Head and Neck Cancer Patients Receiving Photon and Proton Radiation
One main advantage of proton therapy versus photon therapy is its precise radiation delivery to targets without exit dose, resulting in lower dose to surrounding healthy tissues. This is critical given the proximity of head and neck tumors to normal structures. However, proton planning requires careful consideration of factors including air-tissue interface, anatomical uncertainties, surgical artifacts, weight fluctuations, rapid tumor response, and daily variations in setup and anatomy, as these heterogeneities can lead to inaccuracies in targeting and creating unwarranted hotspots to a greater extent than photon radiatio...
Source: International Journal of Radiation Oncology * Biology * Physics - March 16, 2024 Category: Radiology Authors: Irini Youssef, Nader Mohamed, Daniel Kallini, Kaveh Zakeri, Haibo Lin, Dong Han, Hang Qi, Anton Nosov, Nadeem Riaz, Linda Chen, Yao Yu, Lara Ann Dunn, Eric J. Sherman, Rick Wray, Heiko Sch öder, Nancy Y. Lee Source Type: research
An Analysis of Positron Emission Tomography Maximum Standard Uptake Value Among Patients With Head and Neck Cancer Receiving Photon and Proton Radiation
One main advantage of proton therapy versus photon therapy is its precise radiation delivery to targets without exit dose, resulting in lower dose to surrounding healthy tissues. This is critical, given the proximity of head and neck tumors to normal structures. However, proton planning requires careful consideration of factors, including air-tissue interface, anatomic uncertainties, surgical artifacts, weight fluctuations, rapid tumor response, and daily variations in setup and anatomy, as these heterogeneities can lead to inaccuracies in targeting and creating unwarranted hotspots to a greater extent than photon radiatio...
Source: International Journal of Radiation Oncology * Biology * Physics - March 16, 2024 Category: Radiology Authors: Irini Youssef, Nader Mohamed, Daniel Kallini, Kaveh Zakeri, Haibo Lin, Dong Han, Hang Qi, Anton Nosov, Nadeem Riaz, Linda Chen, Yao Yu, Lara Ann Dunn, Eric J. Sherman, Rick Wray, Heiko Sch öder, Nancy Y. Lee Tags: Brief Report Source Type: research
Using the gamma-index analysis for inter-fractional comparison of in-beam PET images for head-and-neck treatment monitoring in proton therapy: A Monte Carlo simulation study
In-beam Positron Emission Tomography (PET) is a technique for in-vivo non-invasive treatment monitoring for proton therapy. To detect anatomical changes in patients with PET, various analysis methods exist, but their clinical interpretation is problematic. The goal of this work is to investigate whether the gamma-index analysis, widely used for dose comparisons, is an appropriate tool for comparing in-beam PET distributions. Focusing on a head-and-neck patient, we investigate whether the gamma-index map and the passing rate are sensitive to progressive anatomical changes. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - March 15, 2024 Category: General Medicine Authors: Aafke Christine Kraan, Martina Moglioni, Giuseppe Battistoni, Davide Bersani, Andrea Berti, Pietro Carra, Piergiorgio Cerello, Mario Ciocca, Veronica Ferrero, Elisa Fiorina, Enrico Mazzoni, Matteo Morrocchi, Silvia Muraro, Ester Orlandi, Francesco Pennazi Tags: Original paper Source Type: research
Proton Re-Irradiation in the Adjuvant Setting for Head and Neck Squamous Cell Carcinoma with High Risk Features
For patients with head and neck squamous cell carcinoma (HNSCC), locoregional failure and second primary tumors are common indications for adjuvant re-irradiation (re-RT). Given an absence of clear consensus on the role of adjuvant reRT, we sought to evaluate histopathologic risk factors of HNSCC patients and their resulting outcomes after adjuvant re-RT with proton therapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: R.L. Bakst, K. Hsieh, E. Genden, K. Sindhu, D.R. Dickstein, M. Posner, W.H. Westra, D. Kirke, S. Roof, B. Culliney, M. Khan, C. Hsieh, M. Urken, R. Chai, J.T. Liu Tags: 142 Source Type: research
