An optimized framework for cone-beam computed tomography-based online evaluation for proton therapy
CONCLUSIONS: An online CBCT evaluation framework was proposed to identify the use of the optimal sCT algorithm regarding efficiency and dosimetry accuracy. The framework is extendable to adopt advanced imaging methods and has the potential to support online adaptive radiotherapy to enhance patient benefits. It could be implemented into clinical use in the future.PMID:37450315 | DOI:10.1002/mp.16625 (Source: Cancer Control)
Source: Cancer Control - July 14, 2023 Category: Cancer & Oncology Authors: Chih-Wei Chang Rasmus Nilsson Sebastian Andersson Duncan Bohannon Sagar A Patel Pretesh R Patel Tian Liu Xiaofeng Yang Jun Zhou Source Type: research
A hybrid method of correcting CBCT for proton range estimation with deep learning and deformable image registration
This study aimed to develop a novel method for generating synthetic CT (sCT) from cone-beam CT (CBCT) of the abdomen/pelvis with bowel gas pockets to facilitate estimation of proton ranges. 

Approach: CBCT, the same-day repeat CT, and the planning CT (pCT) of 81 pediatric patients were used for training (n=60), validation (n=6), and testing (n=15) of the method. The proposed method hybridizes unsupervised deep learning (CycleGAN) and deformable image registration (DIR) of the pCT to CBCT. The CycleGAN and DIR are respectively applied to generate the geometry-weighted (high spatial-frequency) and intensity-...
Source: Physics in Medicine and Biology - July 13, 2023 Category: Physics Authors: Jinsoo Uh Chuang Wang Jacob A Jordan Fakhriddin Pirlepesov Jared B Becksfort Ozgur Ates Matthew J Krasin Chiaho Hua Source Type: research
Proton therapy planning and image-guidance strategies within a randomized controlled trial for high-risk prostate cancer
Clin Transl Radiat Oncol. 2023 Apr 25;41:100632. doi: 10.1016/j.ctro.2023.100632. eCollection 2023 Jul.ABSTRACTThe Danish Prostate Cancer Group is launching the randomized trial, PROstate PROTON Trial 1 (NCT05350475), that compares photons and protons to the prostate and pelvic lymph nodes in treatment of high-risk prostate cancer. The aim of the work described in this paper was, in preparation of this trial, to establish a strategy for conventionally fractionated proton therapy of prostate and elective pelvic lymph nodes that is feasible and robust. Proton treatments are image-guided based on gold fiducial markers and on-...
Source: Clinical Prostate Cancer - July 13, 2023 Category: Cancer & Oncology Authors: Sofie Tilb æk Ludvig Paul Muren Anne Vestergaard Liliana Stolarczyk Heidi S R ønde Tanja S Johansen Jimmi S øndergaard Morten H øyer Jan Alsner Lise N ørgaard Bentzen Stine Elleberg Petersen Source Type: research
A hybrid method of correcting CBCT for proton range estimation with deep learning and deformable image registration
This study aimed to develop a novel method for generating synthetic CT (sCT) from cone-beam CT (CBCT) of the abdomen/pelvis with bowel gas pockets to facilitate estimation of proton ranges. 

Approach: CBCT, the same-day repeat CT, and the planning CT (pCT) of 81 pediatric patients were used for training (n=60), validation (n=6), and testing (n=15) of the method. The proposed method hybridizes unsupervised deep learning (CycleGAN) and deformable image registration (DIR) of the pCT to CBCT. The CycleGAN and DIR are respectively applied to generate the geometry-weighted (high spatial-frequency) and intensity-...
Source: Physics in Medicine and Biology - July 13, 2023 Category: Physics Authors: Jinsoo Uh Chuang Wang Jacob A Jordan Fakhriddin Pirlepesov Jared B Becksfort Ozgur Ates Matthew J Krasin Chiaho Hua Source Type: research
Luminescence imaging of water irradiated by protons under FLASH radiation therapy conditions
Phys Med Biol. 2023 Jul 10. doi: 10.1088/1361-6560/ace60b. Online ahead of print.ABSTRACTFLASH radiation therapy with ultrahigh dose rates (UHDR) has the potential to reduce damage to normal tissue while maintaining anti-tumor efficacy. However, rapid and precise dose distribution measurements remain difficult for FLASH radiation therapy with proton beams. To solve this problem, we performed luminescence imaging of water following irradiation by a UHDR proton beam captured using a charge-coupled device camera. 
Approach: We used 60-MeV proton beams with dose rates of 0.03-837 Gy/s from a cyclotron. Therapeutic 139....
Source: Health Physics - July 10, 2023 Category: Physics Authors: Katsunori Yogo Satoshi Kodaira Tamon Kusumoto Hisashi Kitamura Toshiyuki Toshito Hiromitsu Iwata Masumi Umezawa Masashi Yamada Takuto Miyoshi Masataka Komori Hiroshi Yasuda Jun Kataoka Seiichi Yamamoto Source Type: research
Luminescence imaging of water irradiated by protons under FLASH radiation therapy conditions
Phys Med Biol. 2023 Jul 10. doi: 10.1088/1361-6560/ace60b. Online ahead of print.ABSTRACTFLASH radiation therapy with ultrahigh dose rates (UHDR) has the potential to reduce damage to normal tissue while maintaining anti-tumor efficacy. However, rapid and precise dose distribution measurements remain difficult for FLASH radiation therapy with proton beams. To solve this problem, we performed luminescence imaging of water following irradiation by a UHDR proton beam captured using a charge-coupled device camera. 
Approach: We used 60-MeV proton beams with dose rates of 0.03-837 Gy/s from a cyclotron. Therapeutic 139....
Source: Physics in Medicine and Biology - July 10, 2023 Category: Physics Authors: Katsunori Yogo Satoshi Kodaira Tamon Kusumoto Hisashi Kitamura Toshiyuki Toshito Hiromitsu Iwata Masumi Umezawa Masashi Yamada Takuto Miyoshi Masataka Komori Hiroshi Yasuda Jun Kataoka Seiichi Yamamoto Source Type: research
Luminescence imaging of water irradiated by protons under FLASH radiation therapy conditions
Phys Med Biol. 2023 Jul 10. doi: 10.1088/1361-6560/ace60b. Online ahead of print.ABSTRACTFLASH radiation therapy with ultrahigh dose rates (UHDR) has the potential to reduce damage to normal tissue while maintaining anti-tumor efficacy. However, rapid and precise dose distribution measurements remain difficult for FLASH radiation therapy with proton beams. To solve this problem, we performed luminescence imaging of water following irradiation by a UHDR proton beam captured using a charge-coupled device camera. 
Approach: We used 60-MeV proton beams with dose rates of 0.03-837 Gy/s from a cyclotron. Therapeutic 139....
Source: Physics in Medicine and Biology - July 10, 2023 Category: Physics Authors: Katsunori Yogo Satoshi Kodaira Tamon Kusumoto Hisashi Kitamura Toshiyuki Toshito Hiromitsu Iwata Masumi Umezawa Masashi Yamada Takuto Miyoshi Masataka Komori Hiroshi Yasuda Jun Kataoka Seiichi Yamamoto Source Type: research
Proton Therapy for Unresectable and Medically Inoperable Locally Advanced Pancreatic Cancer: Results From a Multi-Institutional Prospective Registry
CONCLUSIONS: Proton beam RT for LAPC offered excellent tolerability while still maintaining disease control and survival rates comparable with dose-escalated photon-based RT. These findings are consistent with the known physical and dosimetric advantages offered by proton therapy, but the conclusions are limited owing to the patient sample size. Further clinical studies incorporating dose-escalated PBT are warranted to evaluate whether these dosimetric advantages translate into clinically meaningful benefits.PMID:37408677 | PMC:PMC10318270 | DOI:10.1016/j.adro.2023.101250 (Source: Cancer Control)
Source: Cancer Control - July 6, 2023 Category: Cancer & Oncology Authors: Jacob Eckstein J Isabelle Choi Alicia Lozano Nitin Ohri Robert Press Shaakir Hasan Rafi Kabarriti John Chang James Urbanic Michael Durci Nasiruddin Mohammed Craig Stevens Henry Tsai Smith Apisarnthanarax William Regine Carlos Vargas Romaine Nichols Joseph Source Type: research
Proton Therapy for Unresectable and Medically Inoperable Locally Advanced Pancreatic Cancer: Results From a Multi-Institutional Prospective Registry
CONCLUSIONS: Proton beam RT for LAPC offered excellent tolerability while still maintaining disease control and survival rates comparable with dose-escalated photon-based RT. These findings are consistent with the known physical and dosimetric advantages offered by proton therapy, but the conclusions are limited owing to the patient sample size. Further clinical studies incorporating dose-escalated PBT are warranted to evaluate whether these dosimetric advantages translate into clinically meaningful benefits.PMID:37408677 | PMC:PMC10318270 | DOI:10.1016/j.adro.2023.101250 (Source: Adv Data)
Source: Adv Data - July 6, 2023 Category: Epidemiology Authors: Jacob Eckstein J Isabelle Choi Alicia Lozano Nitin Ohri Robert Press Shaakir Hasan Rafi Kabarriti John Chang James Urbanic Michael Durci Nasiruddin Mohammed Craig Stevens Henry Tsai Smith Apisarnthanarax William Regine Carlos Vargas Romaine Nichols Joseph Source Type: research
A portable primary-standard level graphite calorimeter for absolute dosimetry in clinical pencil beam scanning proton beams
Phys Med Biol. 2023 Jul 6. doi: 10.1088/1361-6560/ace50f. Online ahead of print.ABSTRACTTo report the use of a portable primary standard level graphite calorimeter for direct dose determination in clinical pencil beam scanning proton beams, which forms part of the recommendations of the proposed Institute of Physics and Engineering in Medicine (IPEM) Code of Practice (CoP) for proton therapy dosimetry.
Approach: The Primary Standard Proton Calorimeter (PSPC) was developed at the National Physical Laboratory (NPL) and measurements were performed at four clinical proton therapy facilities that use pencil beam scannin...
Source: Physics in Medicine and Biology - July 6, 2023 Category: Physics Authors: Ana Lourenco Nigel Lee Frances Charlwood Jamil Lambert Juan Antonio Vera Mohammad Hussein David R Shipley Francesco Romano Matthew Lowe Matthew Clarke Stefano Lorentini Alejandro Mazal John Pettingell Hugo Palmans Russell A S Thomas Source Type: research
Proton Therapy for Unresectable and Medically Inoperable Locally Advanced Pancreatic Cancer: Results From a Multi-Institutional Prospective Registry
CONCLUSIONS: Proton beam RT for LAPC offered excellent tolerability while still maintaining disease control and survival rates comparable with dose-escalated photon-based RT. These findings are consistent with the known physical and dosimetric advantages offered by proton therapy, but the conclusions are limited owing to the patient sample size. Further clinical studies incorporating dose-escalated PBT are warranted to evaluate whether these dosimetric advantages translate into clinically meaningful benefits.PMID:37408677 | PMC:PMC10318270 | DOI:10.1016/j.adro.2023.101250 (Source: Adv Data)
Source: Adv Data - July 6, 2023 Category: Epidemiology Authors: Jacob Eckstein J Isabelle Choi Alicia Lozano Nitin Ohri Robert Press Shaakir Hasan Rafi Kabarriti John Chang James Urbanic Michael Durci Nasiruddin Mohammed Craig Stevens Henry Tsai Smith Apisarnthanarax William Regine Carlos Vargas Romaine Nichols Joseph Source Type: research
A portable primary-standard level graphite calorimeter for absolute dosimetry in clinical pencil beam scanning proton beams
Phys Med Biol. 2023 Jul 6. doi: 10.1088/1361-6560/ace50f. Online ahead of print.ABSTRACTTo report the use of a portable primary standard level graphite calorimeter for direct dose determination in clinical pencil beam scanning proton beams, which forms part of the recommendations of the proposed Institute of Physics and Engineering in Medicine (IPEM) Code of Practice (CoP) for proton therapy dosimetry.
Approach: The Primary Standard Proton Calorimeter (PSPC) was developed at the National Physical Laboratory (NPL) and measurements were performed at four clinical proton therapy facilities that use pencil beam scannin...
Source: Physics in Medicine and Biology - July 6, 2023 Category: Physics Authors: Ana Lourenco Nigel Lee Frances Charlwood Jamil Lambert Juan Antonio Vera Mohammad Hussein David R Shipley Francesco Romano Matthew Lowe Matthew Clarke Stefano Lorentini Alejandro Mazal John Pettingell Hugo Palmans Russell A S Thomas Source Type: research
Commissioning dose computation model for proton source in pencil beam scanning therapy by convolution neural networks
Phys Med Biol. 2023 Jul 5. doi: 10.1088/1361-6560/ace49b. Online ahead of print.ABSTRACTOBJECTIVE: Proton source model commissioning (PSMC) is critical for ensuring accurate dose calculation in pencil beam scanning (PBS) proton therapy using Monte Carlo (MC) simulations. PSMC aims to match the calculated dose to the delivered dose. However, commissioning the "nominal energy" and "energy spread" parameters in PSMC can be challenging, as these parameters cannot be directly obtained from solving equations. To efficiently and accurately commission the nominal energy and energy spread in a proton source model, we developed a co...
Source: Physics in Medicine and Biology - July 5, 2023 Category: Physics Authors: Yaoying Liu Xuying Shang Wei Zhao Nan Li Baolin Qu Yue Zou Xiaoyun Le Gaolong Zhang Shouping Xu Source Type: research
Applicator-guided proton therapy versus multichannel brachytherapy for vaginal vault irradiation
AbstractTo dosimetrically compare applicator-guided intensity-modulated proton therapy (IMPT) and multichannel brachytherapy (MC-BRT) for vaginal vault irradiation (VVI) with special focus on dose to organs at risk (OARs) and normal tissues. Ten patients with uterine confined endometrial cancer who received adjuvant vaginal cuff brachytherapy were included in this study. For each p atient an additional IMPT treatment plan was created using the same computed tomography dataset and contours segmented for MC-BRT plans. Clinical target volume (CTV) was defined as the proximal 3.5 cm of the vagina including the entire thickn...
Source: Australasian Physical and Engineering Sciences in Medicine - July 5, 2023 Category: Biomedical Engineering Source Type: research
Risk of cardiac implantable device malfunction in cancer patients receiving proton therapy: an overview
Age is a risk factor for both cardiovascular disease and cancer, and as such radiation oncologists frequently see a number of patients with cardiac implantable electronic devices (CIEDs) receiving proton therapy (PT). CIED malfunctions induced by PT are nonnegligible and can occur in both passive scattering and pencil beam scanning modes. In the absence of an evidence-based protocol, the authors emphasise that this patient cohort should be managed differently to electron- and photon- external beam radiation therapy (EBRT) patients due to distinct properties of proton beams. Given the lack of a PT-specific guideline for man...
Source: Frontiers in Oncology - July 4, 2023 Category: Cancer & Oncology Source Type: research
