Changes in Radiation Therapy: New Ultrahypofractionated Radiation, Repeat Breast Conservation Therapy in the Management of Breast Recurrence with Re-irradiation, Proton Therapy
AbstractPurpose of ReviewManagement of breast cancer is multidisciplinary, balancing local and systemic control between treatment modalities. Surgical, radiation, and medical therapies are combined to give the best prognosis. The goal of this review is to examine the advancements in radiotherapy in the treatment of breast cancer.Recent FindingsPublished data supports the shortening of radiation schedules through ultrahypofractionation and utilizing new energy sources through proton beam radiation. Emerging techniques have minimized radiation dosage to organs at risk and skin when compared to traditional radiation sources a...
Source: Current Breast Cancer Reports - March 21, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1217: Longitudinal Assessment of Quality of Life in Nasopharyngeal Cancer Patients Treated with Intensity-Modulated Proton Therapy and Volumetric Modulated Arc Therapy at Different Time Points
Conclusions: Compared to VMAT, dose reduction attributed to IMPT could translate into better functional QoL and HN35 symptoms, but the effect is time dependent and exclusively observed during the RT phase. (Source: Cancers)
Source: Cancers - March 20, 2024 Category: Cancer & Oncology Authors: Kuan-Cho Liao Yu-Jie Huang Wen-Ling Tsai Chien-Hung Lee Fu-Min Fang Tags: Article Source Type: research
An Analysis of PET Maximum SUV Among Head and Neck Cancer Patients Receiving Photon and Proton Radiation
One main advantage of proton therapy versus photon therapy is its precise radiation delivery to targets without exit dose, resulting in lower dose to surrounding healthy tissues. This is critical given the proximity of head and neck tumors to normal structures. However, proton planning requires careful consideration of factors including air-tissue interface, anatomical uncertainties, surgical artifacts, weight fluctuations, rapid tumor response, and daily variations in setup and anatomy, as these heterogeneities can lead to inaccuracies in targeting and creating unwarranted hotspots to a greater extent than photon radiatio...
Source: International Journal of Radiation Oncology * Biology * Physics - March 16, 2024 Category: Radiology Authors: Irini Youssef, Nader Mohamed, Daniel Kallini, Kaveh Zakeri, Haibo Lin, Dong Han, Hang Qi, Anton Nosov, Nadeem Riaz, Linda Chen, Yao Yu, Lara Ann Dunn, Eric J. Sherman, Rick Wray, Heiko Sch öder, Nancy Y. Lee Source Type: research
An Analysis of Positron Emission Tomography Maximum Standard Uptake Value Among Patients With Head and Neck Cancer Receiving Photon and Proton Radiation
One main advantage of proton therapy versus photon therapy is its precise radiation delivery to targets without exit dose, resulting in lower dose to surrounding healthy tissues. This is critical, given the proximity of head and neck tumors to normal structures. However, proton planning requires careful consideration of factors, including air-tissue interface, anatomic uncertainties, surgical artifacts, weight fluctuations, rapid tumor response, and daily variations in setup and anatomy, as these heterogeneities can lead to inaccuracies in targeting and creating unwarranted hotspots to a greater extent than photon radiatio...
Source: International Journal of Radiation Oncology * Biology * Physics - March 16, 2024 Category: Radiology Authors: Irini Youssef, Nader Mohamed, Daniel Kallini, Kaveh Zakeri, Haibo Lin, Dong Han, Hang Qi, Anton Nosov, Nadeem Riaz, Linda Chen, Yao Yu, Lara Ann Dunn, Eric J. Sherman, Rick Wray, Heiko Sch öder, Nancy Y. Lee Tags: Brief Report Source Type: research
Using the gamma-index analysis for inter-fractional comparison of in-beam PET images for head-and-neck treatment monitoring in proton therapy: A Monte Carlo simulation study
In-beam Positron Emission Tomography (PET) is a technique for in-vivo non-invasive treatment monitoring for proton therapy. To detect anatomical changes in patients with PET, various analysis methods exist, but their clinical interpretation is problematic. The goal of this work is to investigate whether the gamma-index analysis, widely used for dose comparisons, is an appropriate tool for comparing in-beam PET distributions. Focusing on a head-and-neck patient, we investigate whether the gamma-index map and the passing rate are sensitive to progressive anatomical changes. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - March 15, 2024 Category: General Medicine Authors: Aafke Christine Kraan, Martina Moglioni, Giuseppe Battistoni, Davide Bersani, Andrea Berti, Pietro Carra, Piergiorgio Cerello, Mario Ciocca, Veronica Ferrero, Elisa Fiorina, Enrico Mazzoni, Matteo Morrocchi, Silvia Muraro, Ester Orlandi, Francesco Pennazi Tags: Original paper Source Type: research
Proton Re-Irradiation in the Adjuvant Setting for Head and Neck Squamous Cell Carcinoma with High Risk Features
For patients with head and neck squamous cell carcinoma (HNSCC), locoregional failure and second primary tumors are common indications for adjuvant re-irradiation (re-RT). Given an absence of clear consensus on the role of adjuvant reRT, we sought to evaluate histopathologic risk factors of HNSCC patients and their resulting outcomes after adjuvant re-RT with proton therapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: R.L. Bakst, K. Hsieh, E. Genden, K. Sindhu, D.R. Dickstein, M. Posner, W.H. Westra, D. Kirke, S. Roof, B. Culliney, M. Khan, C. Hsieh, M. Urken, R. Chai, J.T. Liu Tags: 142 Source Type: research
Outcomes and Genomic Landscape of Patients Treated with Re-Irradiation for Recurrent Head and Neck Cancer Using Pencil Beam Scanning Proton Therapy: The Maryland Proton Treatment Center Experience
We describe clinical outcomes and toxicity of pencil beam scanning proton therapy (PBS-PT) for recurrent HNC, and report genomic alterations associated with patterns of failure to improve clinical decision making. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: R.F. Krc, W. Mendes, J.K. Molitoris, M. Ferris, Y. Song, A.C. Shetty, R. Mehra, J. Papadimitriou, K. Hatten, R. Taylor, J. Wolf, K. Sun, S.M. Bentzen, W.F. Regine, P.T. Tran, M.E. Witek Tags: 151 Source Type: research
Initial Experience of Proton-Based Stereotactic Body Radiotherapy for Head and Neck Reirradiation
Up to 50% of patients with head and neck cancer (HNC) may recur after initial treatment, which often includes a combination of surgery, chemotherapy, and radiation. Reirradiation is an effective treatment option with high rates of local control. Hypofractionated regimens may be desirable due to high biologically effective doses, however they can be complicated by high rates of toxicity. Intensity-modulated proton therapy (IMPT) plans have dosimetric advantages compared to standard photon plans. We sought to review initial patient tolerance and treatment outcomes of proton-based stereotactic body radiotherapy (SBRT) for rei...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: N. Ali, D. Bohannon, J. Zhou, M.W. McDonald, W.A. Stokes, S. Rudra, J.S. Remick, S. Tian, J.E. Bates Tags: 146 Source Type: research
Mitigating Oral Mucositis in Proton Therapy with Advanced Dose-, LET- and Organ Volume-based Constraints
Oral mucositis is one of the most frequent and impairing acute adverse effects of radiotherapy for head and neck malignancies, occurring in almost 100% of patients. Although proton therapy provides a superior sparing of the oral cavity compared to photon therapy, up to 70% of patients still experience oral mucositis. Currently, the only countermeasure for mitigating this sequela is to set dose limits in the oral cavity, whose values have been derived from photon therapy data using the Relative Biological Effectiveness (RBE) as a scaling factor. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: G. Cartechini, S. Liu, C. Washington, S. Samuels, C. La Tessa Tags: 188 Source Type: research
Incidence of Flap Failure Following Sinonasal Surgery, Flap Reconstruction and Postoperative Proton Radiation Therapy
Following sinonasal surgery, orofacial reconstruction often requires the use of tissue flaps (1). Currently, there is a paucity of data addressing the incidence of flap complications following postoperative radiation using proton therapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: F. Yang, I. Ganly, E. Matros, T. Hung, M. Cohen, R.J. Wong, Y. Wu, N.Y. Lee Tags: 184 Source Type: research
Patient-specific 3D CT Images Reconstruction from 2D KV Images
In some proton therapy facilities, patient alignment relies on two 2D orthogonal kV images, taken at fixed, oblique angles, as no 3D on-the-board-imaging is available. The visibility of the tumor in kV images is limited since the patient's 3D anatomy is projected onto a 2D plane, especially when the tumor is behind high-density structures such as bones. This can lead to large patient setup errors. A solution to this problem is to reconstruct the 3D CT image from the kV images obtained at the treatment position. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: Y. Ding, S.H. Patel, J. Holmes, H. Feng, L.A. McGee, J.C. Rwigema, S.A. Vora, W.W. Wong, D.J. Ma, R.L. Foote, B. Li, W. Liu Tags: 218 Source Type: research
The implementation of an image-guided system at a proton therapy center facility
CONCLUSIONS: The system provides excellent image quality and performance, which can be used for IGRT. The proven accuracy of the x-ray imaging and positioning system at McLaren Proton Therapy Center (MPTC) is 1 mm, making it suitable for proton therapy.PMID:38470861 | DOI:10.1002/acm2.14181 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - March 12, 2024 Category: Physics Authors: Bijan Arjomandy Ana Isabel Bejarano Buele Neal Clinthorne Milos Vujasevic Basit Athar James Deemer Ahmad Alkhatib Abrar Hussain Source Type: research
The implementation of an image-guided system at a proton therapy center facility
CONCLUSIONS: The system provides excellent image quality and performance, which can be used for IGRT. The proven accuracy of the x-ray imaging and positioning system at McLaren Proton Therapy Center (MPTC) is 1 mm, making it suitable for proton therapy.PMID:38470861 | DOI:10.1002/acm2.14181 (Source: Health Physics)
Source: Health Physics - March 12, 2024 Category: Physics Authors: Bijan Arjomandy Ana Isabel Bejarano Buele Neal Clinthorne Milos Vujasevic Basit Athar James Deemer Ahmad Alkhatib Abrar Hussain Source Type: research
Adjuvant proton beam therapy in patients with grade 2 meningiomas
CONCLUSION: Our results suggest that adjuvant PBT is well tolerated with minimal radiation toxicity. Alternative to photon radiation, PBT may be considered at least as safe and effective for adjuvant treatment of WHO grade 2 meningiomas when it is available.PMID:38468681 | PMC:PMC10927181 | DOI:10.25259/SNI_485_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - March 12, 2024 Category: Neurosurgery Authors: Taylor Anne Wilson Joseph I Kang Lei Huang Alexandra Vacaru Kevin Nogueira Martins Warren W Boling Source Type: research
Dosimetric impact of bone marrow sparing for robustly optimized IMPT for locally advanced cervical cancer
CONCLUSION: Achieving 1 GyRBE BMS for IMPT is feasible for LACC patients with limited dosimetric impact on other OARs. While further bone marrow dose reduction is possible for some patients, it may increase OAR doses substantially for others. Hence, we recommend a personalized approach when introducing BMS into clinical IMPT treatment planning to carefully assess individual patient benefits and risks.PMID:38471634 | DOI:10.1016/j.radonc.2024.110222 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 12, 2024 Category: Radiology Authors: S C Kuipers J Godart A Corbeau S Breedveld J W M Mens S M de Boer R A Nout M S Hoogeman Source Type: research
