Clinical outcome after pencil beam scanning proton therapy and dysphagia/xerostomia NTCP calculations of proton and photon radiotherapy delivered to patients with cancer of the major salivary glands
CONCLUSION: Our data suggest excellent oncological outcome and low late toxicity rates for patients with SGT treated with PBSPT. NTCP calculation showed a substantial risk reduction for Grade 2 or 3 xerostomia and dysphagia in some SGT patients, while for others, no clear benefit was seen with protons, suggesting that comparative planning should be performed routinely for these patients.ADVANCES IN KNOWLEDGE: We have reported that the clinical outcome of SGT patients treated with PT and compared IMPT to VMAT for the treatment of salivary gland tumour and have observed that protons delivered significantly less dose to organ...
Source: The British Journal of Radiology - May 2, 2023 Category: Radiology Authors: Marc Andrea Walser Nicolas Bachmann Jonas Kluckert A K öthe Carson Tully Dominic Leiser Antony John Lomax Nicola Bizzocchi Johannes Albertus Langendijk Damien C Weber Source Type: research
Clinical outcome after pencil beam scanning proton therapy and dysphagia/xerostomia NTCP calculations of proton and photon radiotherapy delivered to patients with cancer of the major salivary glands
CONCLUSION: Our data suggest excellent oncological outcome and low late toxicity rates for patients with SGT treated with PBSPT. NTCP calculation showed a substantial risk reduction for Grade 2 or 3 xerostomia and dysphagia in some SGT patients, while for others, no clear benefit was seen with protons, suggesting that comparative planning should be performed routinely for these patients.ADVANCES IN KNOWLEDGE: We have reported that the clinical outcome of SGT patients treated with PT and compared IMPT to VMAT for the treatment of salivary gland tumour and have observed that protons delivered significantly less dose to organ...
Source: The British Journal of Radiology - May 2, 2023 Category: Radiology Authors: Marc Andrea Walser Nicolas Bachmann Jonas Kluckert A K öthe Carson Tully Dominic Leiser Antony John Lomax Nicola Bizzocchi Johannes Albertus Langendijk Damien C Weber Source Type: research
Clinical outcome after pencil beam scanning proton therapy and dysphagia/xerostomia NTCP calculations of proton and photon radiotherapy delivered to patients with cancer of the major salivary glands
CONCLUSION: Our data suggest excellent oncological outcome and low late toxicity rates for patients with SGT treated with PBSPT. NTCP calculation showed a substantial risk reduction for Grade 2 or 3 xerostomia and dysphagia in some SGT patients, while for others, no clear benefit was seen with protons, suggesting that comparative planning should be performed routinely for these patients.ADVANCES IN KNOWLEDGE: We have reported that the clinical outcome of SGT patients treated with PT and compared IMPT to VMAT for the treatment of salivary gland tumour and have observed that protons delivered significantly less dose to organ...
Source: The British Journal of Radiology - May 2, 2023 Category: Radiology Authors: Marc Andrea Walser Nicolas Bachmann Jonas Kluckert A K öthe Carson Tully Dominic Leiser Antony John Lomax Nicola Bizzocchi Johannes Albertus Langendijk Damien C Weber Source Type: research
Clinical outcome after pencil beam scanning proton therapy and dysphagia/xerostomia NTCP calculations of proton and photon radiotherapy delivered to patients with cancer of the major salivary glands
CONCLUSION: Our data suggest excellent oncological outcome and low late toxicity rates for patients with SGT treated with PBSPT. NTCP calculation showed a substantial risk reduction for Grade 2 or 3 xerostomia and dysphagia in some SGT patients, while for others, no clear benefit was seen with protons, suggesting that comparative planning should be performed routinely for these patients.ADVANCES IN KNOWLEDGE: We have reported that the clinical outcome of SGT patients treated with PT and compared IMPT to VMAT for the treatment of salivary gland tumour and have observed that protons delivered significantly less dose to organ...
Source: The British Journal of Radiology - May 2, 2023 Category: Radiology Authors: Marc Andrea Walser Nicolas Bachmann Jonas Kluckert A K öthe Carson Tully Dominic Leiser Antony John Lomax Nicola Bizzocchi Johannes Albertus Langendijk Damien C Weber Source Type: research
Clinical outcome after pencil beam scanning proton therapy and dysphagia/xerostomia NTCP calculations of proton and photon radiotherapy delivered to patients with cancer of the major salivary glands
CONCLUSION: Our data suggest excellent oncological outcome and low late toxicity rates for patients with SGT treated with PBSPT. NTCP calculation showed a substantial risk reduction for Grade 2 or 3 xerostomia and dysphagia in some SGT patients, while for others, no clear benefit was seen with protons, suggesting that comparative planning should be performed routinely for these patients.ADVANCES IN KNOWLEDGE: We have reported that the clinical outcome of SGT patients treated with PT and compared IMPT to VMAT for the treatment of salivary gland tumour and have observed that protons delivered significantly less dose to organ...
Source: The British Journal of Radiology - May 2, 2023 Category: Radiology Authors: Marc Andrea Walser Nicolas Bachmann Jonas Kluckert A K öthe Carson Tully Dominic Leiser Antony John Lomax Nicola Bizzocchi Johannes Albertus Langendijk Damien C Weber Source Type: research
Cancers, Vol. 15, Pages 2555: Image-Guided Proton Therapy: A Comprehensive Review
Yang
Image guidance for radiation therapy can improve the accuracy of the delivery of radiation, leading to an improved therapeutic ratio. Proton radiation is able to deliver a highly conformal dose to a target due to its advantageous dosimetric properties, including the Bragg peak. Proton therapy established the standard for daily image guidance as a means of minimizing uncertainties associated with proton treatment. With the increasing adoption of the use of proton therapy over time, image guidance systems for this modality have been changing. The unique properties of proton radiation present a number of differences...
Source: Cancers - April 29, 2023 Category: Cancer & Oncology Authors: Shelby A. Lane Jason M. Slater Gary Y. Yang Tags: Review Source Type: research
Particle beam therapy for pelvic recurrence of colorectal cancer: a registry data analysis in Japan and a systematic review
J Radiat Res. 2023 Apr 28:rrad024. doi: 10.1093/jrr/rrad024. Online ahead of print.ABSTRACTThe aim of this study was to investigate the efficacy and safety of particle beam therapy (PBT) with proton or carbon ion beam for pelvic recurrence of colorectal cancer (PRCC) by comparing the clinical outcomes of a dataset of prospectively enrolled patients for PBT with those from the literature, which were collected by a systematic review of external X-ray radiotherapy (XRT) and PBT. Patients with PRCC treated at 14 domestic facilities between May 2016 and June 2019 and entered the database for prospective observational follow-up ...
Source: Cancer Control - April 28, 2023 Category: Cancer & Oncology Authors: Shigeyuki Murayama Shigeru Yamada Yuichi Hiroshima Hirotoshi Takiyama Hiroshi Taguchi Takuya Kimoto Makoto Anzai Yasuhito Hagiwara Kazuaki Yasui Keita Mori Soichiro Ishihara Hideki Ueno Shinichi Shimizu Hidefumi Aoyama Hiroshi Tsuji Hideyuki Sakurai Source Type: research
Effect of the initial energy layer and spot placement parameters on IMPT delivery efficiency and plan quality
CONCLUSION: Increasing the energy layers spacing can reduce the beam delivery time effectively without compromising IMPT plan quality; increasing the SS had no meaningful impact on beam delivery time and resulted in plan-quality degradation in some cases.PMID:37101399 | DOI:10.1002/acm2.13997 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - April 27, 2023 Category: Physics Authors: Mingyao Zhu Stella Flampouri Alex Stanforth Roelf Slopsema Zachary Diamond William LePain Katja Langen Source Type: research
Effect of the initial energy layer and spot placement parameters on IMPT delivery efficiency and plan quality
CONCLUSION: Increasing the energy layers spacing can reduce the beam delivery time effectively without compromising IMPT plan quality; increasing the SS had no meaningful impact on beam delivery time and resulted in plan-quality degradation in some cases.PMID:37101399 | DOI:10.1002/acm2.13997 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - April 27, 2023 Category: Physics Authors: Mingyao Zhu Stella Flampouri Alex Stanforth Roelf Slopsema Zachary Diamond William LePain Katja Langen Source Type: research
Long-term Outcomes After Moderate Hypofractionated Proton Therapy for Centrally Located Non-small Cell Lung Cancer
CONCLUSION: Moderate hypofractionated PBT may be a useful radiotherapy method for centrally located cT1-T4N0M0 NSCLC.PMID:37097674 | DOI:10.21873/anticanres.16361 (Source: Cell Research)
Source: Cell Research - April 25, 2023 Category: Cytology Authors: Masatoshi Nakamura Hitoshi Ishikawa Kayoko Ohnishi Keiichiro Baba Taisuke Sumiya Motohiro Murakami Yuichi Hiroshima Masashi Mizumoto Toshiyuki Okumura Hideyuki Sakurai Source Type: research
Long-term Outcomes After Moderate Hypofractionated Proton Therapy for Centrally Located Non-small Cell Lung Cancer
CONCLUSION: Moderate hypofractionated PBT may be a useful radiotherapy method for centrally located cT1-T4N0M0 NSCLC.PMID:37097674 | DOI:10.21873/anticanres.16361 (Source: Cancer Control)
Source: Cancer Control - April 25, 2023 Category: Cancer & Oncology Authors: Masatoshi Nakamura Hitoshi Ishikawa Kayoko Ohnishi Keiichiro Baba Taisuke Sumiya Motohiro Murakami Yuichi Hiroshima Masashi Mizumoto Toshiyuki Okumura Hideyuki Sakurai Source Type: research
Hospital-based proton therapy implementation during the COVID pandemic: early clinical and research experience in a European academic institution
ConclusionsHospital-based PBT in European academic institutions was impacted by COVID-19 pandemic, although clinical and research activities were developed and sustained. In the post-pandemic era, the benefits of online learning will shape the future of proton therapy education. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 23, 2023 Category: Cancer & Oncology Source Type: research
Stopping-power ratio of body tissues with updated effective energies and elemental I values for treatment planning of proton therapy and ion beam therapy with helium, carbon, oxygen, and neon ions
Radiol Phys Technol. 2023 Apr 23. doi: 10.1007/s12194-023-00721-6. Online ahead of print.ABSTRACTThe stopping-power ratio (SPR) of body tissues relative to water depends on the particle energy and mean excitation energy (I value) of the tissues. Effective energies to minimize the range error in proton therapy and ion beam therapy with helium, carbon, oxygen, and neon ions and elemental I values have been updated in recent studies. We investigated the effects of these updates on SPR estimation for computed tomography-based treatment planning. The updates led to an increase of up to 0.5% in the SPRs of soft tissues, whereas ...
Source: Health Physics - April 23, 2023 Category: Physics Authors: Taku Inaniwa Emely Weichert Takamitsu Masuda Sodai Tanaka Naruhiro Matsufuji Nobuyuki Kanematsu Source Type: research
Stopping-power ratio of body tissues with updated effective energies and elemental I values for treatment planning of proton therapy and ion beam therapy with helium, carbon, oxygen, and neon ions
AbstractThe stopping-power ratio (SPR) of body tissues relative to water depends on the particle energy and mean excitation energy (I value) of the tissues. Effective energies to minimize the range error in proton therapy and ion beam therapy with helium, carbon, oxygen, and neon ions and elementalI values have been updated in recent studies. We investigated the effects of these updates on SPR estimation for computed tomography-based treatment planning. The updates led to an increase of up to 0.5% in the SPRs of soft tissues, whereas they led to a decrease of up to 1.9% in the SPRs of bone tissues compared with the curre...
Source: Radiological Physics and Technology - April 23, 2023 Category: Physics Source Type: research
In-situ correction of recombination effects in ultra-high dose rate irradiations with protons
Conclusions Correcting recombination effects in our gas-based detectors with the novel method greatly eases the handling of Gantry 1 as "FLASH test bench". Not only is the application of a preset dose more accurate compared to using an empirical correction
curve, also the re-determination of empirical correction curves in the case of a beam phase space change can be omitted.PMID:37084737 | DOI:10.1088/1361-6560/accf5c (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - April 21, 2023 Category: Physics Authors: Robert Michael Sch äfer Serena Psoroulas Damien Charles Weber Source Type: research
