Synthetic CT imaging for PET monitoring in proton therapy: a simulation study
This study addresses a fundamental limitation of In-beam Positron Emission Tomography (IB-PET) in proton therapy: the lack of direct anatomical representation in the images it produces. We aim to overcome this shortcoming by pioneering the application of deep learning techniques to create synthetic control CT images (sCT) from combining IB-PET and planning CT scan data.

Approach. We conducted simulations involving six patients who underwent irradiation with proton beams. Leveraging the architecture of a Visual Transformer (ViT) Neural Network (NN), we developed a model to generate sCT images of these patie...
Source: Physics in Medicine and Biology - February 19, 2024 Category: Physics Authors: Martina Moglioni Pietro Carra Silvia Arezzini Nicola Belcari Davide Bersani Andrea Berti Maria Giuseppina Bisogni Marco Calderisi Ilaria Ceppa Piergiorgio Cerello Mario Ciocca Veronica Ferrero Elisa Fiorina Aafke Christine Kraan Enrico Mazzoni Matteo Morr Source Type: research
A fast and robust constraint-based online re-optimization approach for automated online adaptive intensity modulated proton therapy in head and neck cancer
Phys Med Biol. 2024 Feb 19. doi: 10.1088/1361-6560/ad2a98. Online ahead of print.ABSTRACTObjective - In head-and-neck cancer intensity modulated proton therapy (IMPT), adaptive radiotherapy is currently restricted to offline re-planning, mitigating the effect of slow changes in patient anatomies. Daily online adaptations can potentially improve dosimetry. Here, a new, fully automated online re-optimization strategy is presented. In a retrospective study, this online re-optimization approach was compared to our trigger-based offline re-planning (offlineTB re-planning) schedule, including extensive robustness analyses.&#...
Source: Physics in Medicine and Biology - February 19, 2024 Category: Physics Authors: Michelle Oud Sebastiaan Breedveld Jesus Rojo-Santiago Marta Krystyna Gi żyńska Michiel Kroesen Steven Habraken Zolt án Perkó Ben J M Heijmen Mischa S Hoogeman Source Type: research
A retrospective study on the investigation of potential dosimetric benefits of online adaptive proton therapy for head and neck cancer
CONCLUSION: The results of our retrospective study have demonstrated that online APT can better address anatomical changes for HN cancer patients than the current offline replanning practice. The advanced artificial intelligence based automatic replanning technology presents a promising avenue for extending potential benefits of online APT.PMID:38368614 | DOI:10.1002/acm2.14308 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - February 18, 2024 Category: Physics Authors: Chih-Wei Chang Duncan Bohannon Zhen Tian Yinan Wang Mark W Mcdonald David S Yu Tian Liu Jun Zhou Xiaofeng Yang Source Type: research
A retrospective study on the investigation of potential dosimetric benefits of online adaptive proton therapy for head and neck cancer
CONCLUSION: The results of our retrospective study have demonstrated that online APT can better address anatomical changes for HN cancer patients than the current offline replanning practice. The advanced artificial intelligence based automatic replanning technology presents a promising avenue for extending potential benefits of online APT.PMID:38368614 | DOI:10.1002/acm2.14308 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - February 18, 2024 Category: Physics Authors: Chih-Wei Chang Duncan Bohannon Zhen Tian Yinan Wang Mark W Mcdonald David S Yu Tian Liu Jun Zhou Xiaofeng Yang Source Type: research
Brainstem toxicity after proton or photon therapy in children and young adults with localized intracranial ependymoma: a French retrospective study
CONCLUSION: Asymptomatic radiographic changes occurred in 4.8% of patients with ependymoma in a large national series. There was no correlation with dose or technique. No symptomatic brainstem injury was identified.PMID:38367939 | DOI:10.1016/j.radonc.2024.110157 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 17, 2024 Category: Radiology Authors: C éline Dalmasso Claire Alapetite St éphanie Bolle Farid Goudjil Am élie Lusque Jacques Desrousseaux Line Claude J érome Doyen Val érie Bernier-Chastagner Anne Ducassou Annick Sevely Margaux Roques Fatima Tensaouti Anne Laprie Source Type: research
Brainstem toxicity after proton or photon therapy in children and young adults with localized intracranial ependymoma: a French retrospective study
CONCLUSION: Asymptomatic radiographic changes occurred in 4.8% of patients with ependymoma in a large national series. There was no correlation with dose or technique. No symptomatic brainstem injury was identified.PMID:38367939 | DOI:10.1016/j.radonc.2024.110157 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 17, 2024 Category: Radiology Authors: C éline Dalmasso Claire Alapetite St éphanie Bolle Farid Goudjil Am élie Lusque Jacques Desrousseaux Line Claude J érome Doyen Val érie Bernier-Chastagner Anne Ducassou Annick Sevely Margaux Roques Fatima Tensaouti Anne Laprie Source Type: research
Cancers, Vol. 16, Pages 784: Radiation Therapy for Stage IIA/B Seminoma: Modeling Secondary Cancer Risk for Protons and VMAT versus 3D Photons
This study assessed differences in secondary cancer risk for stage II seminoma patients following proton pencil-beam scanning (PBS) and photon VMAT, compared to 3D conformal photon RT. Ten seminoma patients, five with a IIA staging who received 30 GyRBE and five with a IIB staging who received 36 GyRBE, had three RT plans generated. Doses to organs at risk (OAR) were evaluated, and secondary cancer risks were calculated as the Excess Absolute Risk (EAR) and Lifetime Attributable Risk (LAR). PBS reduced the mean OAR dose by 60% on average compared to 3D, and reduced the EAR and LAR for all OAR, with the greatest reductions ...
Source: Cancers - February 15, 2024 Category: Cancer & Oncology Authors: Jennifer Pursley Kyla Remillard Nicolas Depauw Grace Lee Clemens Grassberger Harald Paganetti Jason A. Efstathiou Sophia C. Kamran Tags: Article Source Type: research
Cancers, Vol. 16, Pages 798: Pencil Beam Scanning Proton Bragg Peak Conformal FLASH in Prostate Cancer Stereotactic Body Radiotherapy
In conclusion, the Bragg peak distal tracking method can yield comparable plan quality in most OARs while preserving sufficient FLASH dose rate coverage, demonstrating that the ultra-high dose technique can be applied in prostate FLASH SBRT. (Source: Cancers)
Source: Cancers - February 15, 2024 Category: Cancer & Oncology Authors: Tyler Kaulfers Grant Lattery Chingyun Cheng Xingyi Zhao Balaji Selvaraj Hui Wu Arpit M. Chhabra Jehee Isabelle Choi Haibo Lin Charles B. Simone Simone Shaakir Hasan Minglei Kang Jenghwa Chang Tags: Article Source Type: research
Correspondence: Comprehensive insights on the underlying potential and advantage of proton therapy over intensity-modulated photon radiation therapy as highlighted in a wide real world data analysis
Radiother Oncol. 2024 Feb 12:110146. doi: 10.1016/j.radonc.2024.110146. Online ahead of print.NO ABSTRACTPMID:38354954 | DOI:10.1016/j.radonc.2024.110146 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 14, 2024 Category: Radiology Authors: Chia-Lun Chang Kuan-Chou Lin Wan-Ming Chen Ben-Chang Shia Szu-Yuan Wu Source Type: research
Correspondence: Comprehensive insights on the underlying potential and advantage of proton therapy over intensity-modulated photon radiation therapy as highlighted in a wide real world data analysis
Radiother Oncol. 2024 Feb 12:110146. doi: 10.1016/j.radonc.2024.110146. Online ahead of print.NO ABSTRACTPMID:38354954 | DOI:10.1016/j.radonc.2024.110146 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 14, 2024 Category: Radiology Authors: Chia-Lun Chang Kuan-Chou Lin Wan-Ming Chen Ben-Chang Shia Szu-Yuan Wu Source Type: research
Correspondence: Comprehensive insights on the underlying potential and advantage of proton therapy over intensity-modulated photon radiation therapy as highlighted in a wide real world data analysis
Radiother Oncol. 2024 Feb 12:110146. doi: 10.1016/j.radonc.2024.110146. Online ahead of print.NO ABSTRACTPMID:38354954 | DOI:10.1016/j.radonc.2024.110146 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 14, 2024 Category: Radiology Authors: Chia-Lun Chang Kuan-Chou Lin Wan-Ming Chen Ben-Chang Shia Szu-Yuan Wu Source Type: research
Cancers, Vol. 16, Pages 780: Potential Therapeutic Improvements in Prostate Cancer Treatment Using Pencil Beam Scanning Proton Therapy with LETd Optimization and Disease-Specific RBE Models
Conclusion: The demonstration of improved TODRs provided via LETd optimization shows potential for improved patient outcomes. (Source: Cancers)
Source: Cancers - February 14, 2024 Category: Cancer & Oncology Authors: Michael Vieceli Jiyeon Park Wen Chien Hsi Mo Saki Nancy P. Mendenhall Perry Johnson Mark Artz Tags: Article Source Type: research
OPTIma: simplifying calorimetry for proton computed tomography in high proton flux environments
Phys Med Biol. 2024 Feb 12. doi: 10.1088/1361-6560/ad2883. Online ahead of print.ABSTRACTOBJECTIVE: Proton computed tomography (pCT) offers a potential route to reducing range uncertainties for proton therapy treatment planning, however the current trend towards high current spot scanning treatment systems leads to high proton fluxes which are challenging for existing systems. Here we demonstrate a novel approach to energy reconstruction, referred to as "de-averaging", which allows individual proton energies to be recovered using only a measurement of their integrated energy without the need for spatial information from th...
Source: Physics in Medicine and Biology - February 12, 2024 Category: Physics Authors: Alasdair Winter Bart Vorselaars Michela Esposito Amir Badiee Tony Price Philip Patrick Allport Nigel Allinson Source Type: research
High dose proton and photon-based radiation therapy for 213 liver lesions: a multi-institutional dosimetric comparison with a clinical perspective
ConclusionsCyberknife and V-MAT FFF with 5mm jaws spare more liver than V-MAT FF with 10 mm jaws. PT spare more liver compared to photons. FOV and FOVR allows a quantitative analysis of healthy tissue sparing performance showing also the quality of plan in terms of dose fall-off. (Source: La Radiologia Medica)
Source: La Radiologia Medica - February 12, 2024 Category: Radiology Source Type: research
Correspondence: Comprehensive insights on the underlying potential and advantage of proton therapy over intensity-modulated photon radiation therapy as highlighted in a wide real world data analysis
Dear Editor, (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - February 11, 2024 Category: Radiology Authors: Chia-Lun Chang, Kuan-Chou Lin, Wan-Ming Chen, Ben-Chang Shia, Szu-Yuan Wu Tags: Letter to the Editor Source Type: research
