Brainstem toxicity after proton or photon therapy in children and young adults with localized intracranial ependymoma: a French retrospective study
CONCLUSION: Asymptomatic radiographic changes occurred in 4.8% of patients with ependymoma in a large national series. There was no correlation with dose or technique. No symptomatic brainstem injury was identified.PMID:38367939 | DOI:10.1016/j.radonc.2024.110157 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 17, 2024 Category: Radiology Authors: C éline Dalmasso Claire Alapetite St éphanie Bolle Farid Goudjil Am élie Lusque Jacques Desrousseaux Line Claude J érome Doyen Val érie Bernier-Chastagner Anne Ducassou Annick Sevely Margaux Roques Fatima Tensaouti Anne Laprie Source Type: research
Cancers, Vol. 16, Pages 784: Radiation Therapy for Stage IIA/B Seminoma: Modeling Secondary Cancer Risk for Protons and VMAT versus 3D Photons
This study assessed differences in secondary cancer risk for stage II seminoma patients following proton pencil-beam scanning (PBS) and photon VMAT, compared to 3D conformal photon RT. Ten seminoma patients, five with a IIA staging who received 30 GyRBE and five with a IIB staging who received 36 GyRBE, had three RT plans generated. Doses to organs at risk (OAR) were evaluated, and secondary cancer risks were calculated as the Excess Absolute Risk (EAR) and Lifetime Attributable Risk (LAR). PBS reduced the mean OAR dose by 60% on average compared to 3D, and reduced the EAR and LAR for all OAR, with the greatest reductions ...
Source: Cancers - February 15, 2024 Category: Cancer & Oncology Authors: Jennifer Pursley Kyla Remillard Nicolas Depauw Grace Lee Clemens Grassberger Harald Paganetti Jason A. Efstathiou Sophia C. Kamran Tags: Article Source Type: research
Cancers, Vol. 16, Pages 798: Pencil Beam Scanning Proton Bragg Peak Conformal FLASH in Prostate Cancer Stereotactic Body Radiotherapy
In conclusion, the Bragg peak distal tracking method can yield comparable plan quality in most OARs while preserving sufficient FLASH dose rate coverage, demonstrating that the ultra-high dose technique can be applied in prostate FLASH SBRT. (Source: Cancers)
Source: Cancers - February 15, 2024 Category: Cancer & Oncology Authors: Tyler Kaulfers Grant Lattery Chingyun Cheng Xingyi Zhao Balaji Selvaraj Hui Wu Arpit M. Chhabra Jehee Isabelle Choi Haibo Lin Charles B. Simone Simone Shaakir Hasan Minglei Kang Jenghwa Chang Tags: Article Source Type: research
Correspondence: Comprehensive insights on the underlying potential and advantage of proton therapy over intensity-modulated photon radiation therapy as highlighted in a wide real world data analysis
Radiother Oncol. 2024 Feb 12:110146. doi: 10.1016/j.radonc.2024.110146. Online ahead of print.NO ABSTRACTPMID:38354954 | DOI:10.1016/j.radonc.2024.110146 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 14, 2024 Category: Radiology Authors: Chia-Lun Chang Kuan-Chou Lin Wan-Ming Chen Ben-Chang Shia Szu-Yuan Wu Source Type: research
Correspondence: Comprehensive insights on the underlying potential and advantage of proton therapy over intensity-modulated photon radiation therapy as highlighted in a wide real world data analysis
Radiother Oncol. 2024 Feb 12:110146. doi: 10.1016/j.radonc.2024.110146. Online ahead of print.NO ABSTRACTPMID:38354954 | DOI:10.1016/j.radonc.2024.110146 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 14, 2024 Category: Radiology Authors: Chia-Lun Chang Kuan-Chou Lin Wan-Ming Chen Ben-Chang Shia Szu-Yuan Wu Source Type: research
Correspondence: Comprehensive insights on the underlying potential and advantage of proton therapy over intensity-modulated photon radiation therapy as highlighted in a wide real world data analysis
Radiother Oncol. 2024 Feb 12:110146. doi: 10.1016/j.radonc.2024.110146. Online ahead of print.NO ABSTRACTPMID:38354954 | DOI:10.1016/j.radonc.2024.110146 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 14, 2024 Category: Radiology Authors: Chia-Lun Chang Kuan-Chou Lin Wan-Ming Chen Ben-Chang Shia Szu-Yuan Wu Source Type: research
Cancers, Vol. 16, Pages 780: Potential Therapeutic Improvements in Prostate Cancer Treatment Using Pencil Beam Scanning Proton Therapy with LETd Optimization and Disease-Specific RBE Models
Conclusion: The demonstration of improved TODRs provided via LETd optimization shows potential for improved patient outcomes. (Source: Cancers)
Source: Cancers - February 14, 2024 Category: Cancer & Oncology Authors: Michael Vieceli Jiyeon Park Wen Chien Hsi Mo Saki Nancy P. Mendenhall Perry Johnson Mark Artz Tags: Article Source Type: research
OPTIma: simplifying calorimetry for proton computed tomography in high proton flux environments
Phys Med Biol. 2024 Feb 12. doi: 10.1088/1361-6560/ad2883. Online ahead of print.ABSTRACTOBJECTIVE: Proton computed tomography (pCT) offers a potential route to reducing range uncertainties for proton therapy treatment planning, however the current trend towards high current spot scanning treatment systems leads to high proton fluxes which are challenging for existing systems. Here we demonstrate a novel approach to energy reconstruction, referred to as "de-averaging", which allows individual proton energies to be recovered using only a measurement of their integrated energy without the need for spatial information from th...
Source: Physics in Medicine and Biology - February 12, 2024 Category: Physics Authors: Alasdair Winter Bart Vorselaars Michela Esposito Amir Badiee Tony Price Philip Patrick Allport Nigel Allinson Source Type: research
High dose proton and photon-based radiation therapy for 213 liver lesions: a multi-institutional dosimetric comparison with a clinical perspective
ConclusionsCyberknife and V-MAT FFF with 5mm jaws spare more liver than V-MAT FF with 10 mm jaws. PT spare more liver compared to photons. FOV and FOVR allows a quantitative analysis of healthy tissue sparing performance showing also the quality of plan in terms of dose fall-off. (Source: La Radiologia Medica)
Source: La Radiologia Medica - February 12, 2024 Category: Radiology Source Type: research
Correspondence: Comprehensive insights on the underlying potential and advantage of proton therapy over intensity-modulated photon radiation therapy as highlighted in a wide real world data analysis
Dear Editor, (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - February 11, 2024 Category: Radiology Authors: Chia-Lun Chang, Kuan-Chou Lin, Wan-Ming Chen, Ben-Chang Shia, Szu-Yuan Wu Tags: Letter to the Editor Source Type: research
First direct machine-specific parameters incorporated in Spot-scanning Proton Arc (SPArc) optimization algorithm
CONCLUSIONS: For the first time, clinical users not only could generate a SPArc plan meeting the mechanical constraint of their proton system but also directly control the arc treatment speed and momentum changes of the gantry during the plan optimization process. This work paved the way for the routine clinical implementation of proton arc therapy in the treatment planning system.PMID:38340368 | DOI:10.1002/mp.16985 (Source: Health Physics)
Source: Health Physics - February 10, 2024 Category: Physics Authors: Gang Liu Qingkun Fan Lewei Zhao Peilin Liu Xiaoda Cong Di Yan Xiaoqiang Li Xuanfeng Ding Source Type: research
Voxel-wise dose rate calculation in clinical pencil beam scanning proton therapy
Phys Med Biol. 2024 Feb 7. doi: 10.1088/1361-6560/ad2713. Online ahead of print.ABSTRACTClinical outcomes after proton therapy have shown some variability that is not fully understood. Different approaches have been suggested to explain the biological outcome, but none has yet provided a comprehensive and satisfactory rationale for observed toxicities. The relatively recent transition from passive scattering (PS) to pencil beam scanning (PBS) treatments has significantly increased the voxel-wise dose rate in proton therapy. In addition, the dose rate distribution is no longer uniform along the cross section of the target b...
Source: Physics in Medicine and Biology - February 7, 2024 Category: Physics Authors: Juliane Daartz Thomas Madden Arthur Lalonde Ethan Cascio Joost M Verburg Helen Shih Shannon MacDonald Rachael Hachadorian Jan Schuemann Source Type: research
Impact of and interplay between proton arc therapy and range uncertainties in proton therapy for head-and-neck cancer
Phys Med Biol. 2024 Feb 7. doi: 10.1088/1361-6560/ad2718. Online ahead of print.ABSTRACTProton therapy reduces the integral dose to the patient compared to conventional photon treatments. However, in vivo proton range uncertainties remain a considerable hurdle. Range uncertainty reduction benefits depend on clinical practices. During intensity-modulated proton therapy (IMPT), the target is irradiated from only a few directions, but proton arc therapy (PAT), for which the target is irradiated from dozens of angles, may see clinical implementation by the time considerable range uncertainty reductions are achieved. It is ther...
Source: Physics in Medicine and Biology - February 7, 2024 Category: Physics Authors: Sebastian Tattenberg Peilin Liu Anthony Mulhem Xiaoda Cong Christopher Thome Xuanfeng Ding Source Type: research
Comprehensive insights on the underlying potential and advantage of proton therapy over intensity-modulated photon radiation therapy as highlighted in a wide real world data analysis
Radiother Oncol. 2024 Feb 1:110122. doi: 10.1016/j.radonc.2024.110122. Online ahead of print.NO ABSTRACTPMID:38309585 | DOI:10.1016/j.radonc.2024.110122 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 3, 2024 Category: Radiology Authors: Ester Orlandi Giulia Fontana Lisa Licitra Carmine Tinelli Anna Maria Camarda Cai Grau Steven Jay Frank Source Type: research
Disease and toxicity outcomes for a modern cohort of patients with squamous cell carcinoma of cutaneous origin involving the parotid gland: Comparison of volumetric modulated arc therapy and pencil beam scanning proton therapy
CONCLUSIONS: Cutaneous SCC involving the parotid can be an aggressive clinical entity despite modern multimodal therapy. PBT offers significantly lower dose to organs at risk compared to VMAT, which seemingly yields diminished acute toxicities.PMID:38309587 | DOI:10.1016/j.radonc.2024.110112 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 3, 2024 Category: Radiology Authors: Reza Zarinshenas Peter Campbell Kai Sun Jason K Molitoris Akshar N Patel Matthew E Witek Kevin J Cullen Ranee Mehra Kyle M Hatten Kelly F Moyer Rodney J Taylor Kalpesh T Vakharia Jeffrey S Wolf Matthew J Ferris Source Type: research
