Is oligometastatic disease an applicable and useful concept in haematologic malignancies? A narrative review of radiation therapy standards, modern techniques, and innovations
CONCLUSIONS: Given the effectiveness of systemic treatments in hematologic malignancies, the oligometastasis stage is of little importance. A curative intent after local radiation therapy, even advanced stage, is possible, both with residual disease for advanced Hodgkin lymphoma, aggressive non-Hodgkin lymphoma, or solitary plasmocytoma, and even without evidence of disease after chemotherapy for Hodgkin or non-Hodgkin lymphoma. The role of new treatments, such as CAR T cells, allows us to consider radiation therapy after systemic treatment of relapsed diseases with low volume recurrence, which can be considered oligorecur...
Source: Cancer Radiotherapie - December 24, 2023 Category: Cancer & Oncology Authors: L Ollivier K Debbi N-H To A Cailleteau S Supiot A Mervoyer V Guimas Y Belkac émi Source Type: research
A quantitative framework for patient-specific collision detection in proton therapy
CONCLUSION: Implementation of this framework reduces incidence of collisions in the treatment room. In addition, it enables the planners to minimize the air gap and achieve better plan dosimetry.PMID:38131514 | DOI:10.1002/acm2.14247 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - December 22, 2023 Category: Physics Authors: Stephen K Northway Bailey M Vallejo Lawrence Liu Emily E Hansen Shikui Tang Dennis Mah Iain J MacEwan James J Urbanic Chang Chang Source Type: research
Variable RBE in proton radiotherapy: a comparative study with the predictive Mayo Clinic Florida microdosimetric kinetic model and phenomenological models of cell survival
Phys Med Biol. 2023 Dec 22;68(18). doi: 10.1088/1361-6560/acf43b.ABSTRACTObjectives. (1) To examine to what extent the cell- and exposure- specific information neglected in the phenomenological proton relative biological effectiveness (RBE) models could influence the computed RBE in proton therapy. (2) To explore similarities and differences in the formalism and the results between the linear energy transfer (LET)-based phenomenological proton RBE models and the microdosimetry-based Mayo Clinic Florida microdosimetric kinetic model (MCF MKM). (3) To investigate how the relationship between the RBE and the dose-mean proton ...
Source: Physics in Medicine and Biology - December 22, 2023 Category: Physics Authors: Alessio Parisi Chris J Beltran Keith M Furutani Source Type: research
Variable RBE in proton radiotherapy: a comparative study with the predictive Mayo Clinic Florida microdosimetric kinetic model and phenomenological models of cell survival
Phys Med Biol. 2023 Dec 22;68(18). doi: 10.1088/1361-6560/acf43b.ABSTRACTObjectives. (1) To examine to what extent the cell- and exposure- specific information neglected in the phenomenological proton relative biological effectiveness (RBE) models could influence the computed RBE in proton therapy. (2) To explore similarities and differences in the formalism and the results between the linear energy transfer (LET)-based phenomenological proton RBE models and the microdosimetry-based Mayo Clinic Florida microdosimetric kinetic model (MCF MKM). (3) To investigate how the relationship between the RBE and the dose-mean proton ...
Source: Physics in Medicine and Biology - December 22, 2023 Category: Physics Authors: Alessio Parisi Chris J Beltran Keith M Furutani Source Type: research
A quantitative framework for patient-specific collision detection in proton therapy
CONCLUSION: Implementation of this framework reduces incidence of collisions in the treatment room. In addition, it enables the planners to minimize the air gap and achieve better plan dosimetry.PMID:38131514 | DOI:10.1002/acm2.14247 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - December 22, 2023 Category: Physics Authors: Stephen K Northway Bailey M Vallejo Lawrence Liu Emily E Hansen Shikui Tang Dennis Mah Iain J MacEwan James J Urbanic Chang Chang Source Type: research
Variable RBE in proton radiotherapy: a comparative study with the predictive Mayo Clinic Florida microdosimetric kinetic model and phenomenological models of cell survival
Phys Med Biol. 2023 Dec 22;68(18). doi: 10.1088/1361-6560/acf43b.ABSTRACTObjectives. (1) To examine to what extent the cell- and exposure- specific information neglected in the phenomenological proton relative biological effectiveness (RBE) models could influence the computed RBE in proton therapy. (2) To explore similarities and differences in the formalism and the results between the linear energy transfer (LET)-based phenomenological proton RBE models and the microdosimetry-based Mayo Clinic Florida microdosimetric kinetic model (MCF MKM). (3) To investigate how the relationship between the RBE and the dose-mean proton ...
Source: Physics in Medicine and Biology - December 22, 2023 Category: Physics Authors: Alessio Parisi Chris J Beltran Keith M Furutani Source Type: research
Variable RBE in proton radiotherapy: a comparative study with the predictive Mayo Clinic Florida microdosimetric kinetic model and phenomenological models of cell survival
Phys Med Biol. 2023 Dec 22;68(18). doi: 10.1088/1361-6560/acf43b.ABSTRACTObjectives. (1) To examine to what extent the cell- and exposure- specific information neglected in the phenomenological proton relative biological effectiveness (RBE) models could influence the computed RBE in proton therapy. (2) To explore similarities and differences in the formalism and the results between the linear energy transfer (LET)-based phenomenological proton RBE models and the microdosimetry-based Mayo Clinic Florida microdosimetric kinetic model (MCF MKM). (3) To investigate how the relationship between the RBE and the dose-mean proton ...
Source: Physics in Medicine and Biology - December 22, 2023 Category: Physics Authors: Alessio Parisi Chris J Beltran Keith M Furutani Source Type: research
Variable RBE in proton radiotherapy: a comparative study with the predictive Mayo Clinic Florida microdosimetric kinetic model and phenomenological models of cell survival
Phys Med Biol. 2023 Dec 22;68(18). doi: 10.1088/1361-6560/acf43b.ABSTRACTObjectives. (1) To examine to what extent the cell- and exposure- specific information neglected in the phenomenological proton relative biological effectiveness (RBE) models could influence the computed RBE in proton therapy. (2) To explore similarities and differences in the formalism and the results between the linear energy transfer (LET)-based phenomenological proton RBE models and the microdosimetry-based Mayo Clinic Florida microdosimetric kinetic model (MCF MKM). (3) To investigate how the relationship between the RBE and the dose-mean proton ...
Source: Physics in Medicine and Biology - December 22, 2023 Category: Physics Authors: Alessio Parisi Chris J Beltran Keith M Furutani Source Type: research
Variable RBE in proton radiotherapy: a comparative study with the predictive Mayo Clinic Florida microdosimetric kinetic model and phenomenological models of cell survival
Phys Med Biol. 2023 Dec 22;68(18). doi: 10.1088/1361-6560/acf43b.ABSTRACTObjectives. (1) To examine to what extent the cell- and exposure- specific information neglected in the phenomenological proton relative biological effectiveness (RBE) models could influence the computed RBE in proton therapy. (2) To explore similarities and differences in the formalism and the results between the linear energy transfer (LET)-based phenomenological proton RBE models and the microdosimetry-based Mayo Clinic Florida microdosimetric kinetic model (MCF MKM). (3) To investigate how the relationship between the RBE and the dose-mean proton ...
Source: Physics in Medicine and Biology - December 22, 2023 Category: Physics Authors: Alessio Parisi Chris J Beltran Keith M Furutani Source Type: research
Variable RBE in proton radiotherapy: a comparative study with the predictive Mayo Clinic Florida microdosimetric kinetic model and phenomenological models of cell survival
Phys Med Biol. 2023 Dec 22;68(18). doi: 10.1088/1361-6560/acf43b.ABSTRACTObjectives. (1) To examine to what extent the cell- and exposure- specific information neglected in the phenomenological proton relative biological effectiveness (RBE) models could influence the computed RBE in proton therapy. (2) To explore similarities and differences in the formalism and the results between the linear energy transfer (LET)-based phenomenological proton RBE models and the microdosimetry-based Mayo Clinic Florida microdosimetric kinetic model (MCF MKM). (3) To investigate how the relationship between the RBE and the dose-mean proton ...
Source: Physics in Medicine and Biology - December 22, 2023 Category: Physics Authors: Alessio Parisi Chris J Beltran Keith M Furutani Source Type: research
Variable RBE in proton radiotherapy: a comparative study with the predictive Mayo Clinic Florida microdosimetric kinetic model and phenomenological models of cell survival
Phys Med Biol. 2023 Dec 22;68(18). doi: 10.1088/1361-6560/acf43b.ABSTRACTObjectives. (1) To examine to what extent the cell- and exposure- specific information neglected in the phenomenological proton relative biological effectiveness (RBE) models could influence the computed RBE in proton therapy. (2) To explore similarities and differences in the formalism and the results between the linear energy transfer (LET)-based phenomenological proton RBE models and the microdosimetry-based Mayo Clinic Florida microdosimetric kinetic model (MCF MKM). (3) To investigate how the relationship between the RBE and the dose-mean proton ...
Source: Physics in Medicine and Biology - December 22, 2023 Category: Physics Authors: Alessio Parisi Chris J Beltran Keith M Furutani Source Type: research
Variable RBE in proton radiotherapy: a comparative study with the predictive Mayo Clinic Florida microdosimetric kinetic model and phenomenological models of cell survival
Phys Med Biol. 2023 Dec 22;68(18). doi: 10.1088/1361-6560/acf43b.ABSTRACTObjectives. (1) To examine to what extent the cell- and exposure- specific information neglected in the phenomenological proton relative biological effectiveness (RBE) models could influence the computed RBE in proton therapy. (2) To explore similarities and differences in the formalism and the results between the linear energy transfer (LET)-based phenomenological proton RBE models and the microdosimetry-based Mayo Clinic Florida microdosimetric kinetic model (MCF MKM). (3) To investigate how the relationship between the RBE and the dose-mean proton ...
Source: Physics in Medicine and Biology - December 22, 2023 Category: Physics Authors: Alessio Parisi Chris J Beltran Keith M Furutani Source Type: research
Technical note: Implementing MRI/CT-based elemental concentration data to Monte Carlo simulation for yielding positron emitters in proton therapy
CONCLUSION: At least in the head area, the MRWC/CT method demonstrated potential for more precise predictions of proton-induced positron emitter distributions via MC simulations than that of the CT-only method.PMID:38116829 | DOI:10.1002/mp.16896 (Source: Health Physics)
Source: Health Physics - December 20, 2023 Category: Physics Authors: Masatoshi Saito Ryuga Matsumoto Source Type: research
Technical note: Implementing MRI/CT-based elemental concentration data to Monte Carlo simulation for yielding positron emitters in proton therapy
CONCLUSION: At least in the head area, the MRWC/CT method demonstrated potential for more precise predictions of proton-induced positron emitter distributions via MC simulations than that of the CT-only method.PMID:38116829 | DOI:10.1002/mp.16896 (Source: Health Physics)
Source: Health Physics - December 20, 2023 Category: Physics Authors: Masatoshi Saito Ryuga Matsumoto Source Type: research
Ten-year experience with intracameral chemotherapy for aqueous seeding in retinoblastoma: long-term efficacy, safety and toxicity
Conclusion
ICC appears to be safe and efficient for AS without irreversible vision-threatening adverse effects. More data are needed to determine any superiority in efficiency/toxicity of topotecan versus melphalan. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Stathopoulos, C., Beck-Popovic, M., Moulin, A. P., Munier, F. L. Tags: Open access Oncology Source Type: research
