Nowadays proton therapy: Double scattering versus pencil beam scanning mode
Pencil beam scanning mode is becoming widely used in proton therapy. The biological consequences of the use of pencil beam scanning instead of double scattering mode have not been studied in detail yet. Most of the biological studies of relative biological effectiveness of protons were carried out using double scattering mode. The dose rates in pencil beam scanning are locally essentially higher than those in double scattering mode, which could affect the cell response. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - August 27, 2016 Category: Journals (General) Authors: Anna Michaelidesov á, Jana Konířová, Jana Vachelová, Vladimír Vondráček, Marie Davídková Source Type: research

Effect of scattering angle on energy loss radiography imaging for various proton energies relevant in proton therapy: A simulation study
The quality of cancer treatment with protons critically depends on the accurate determination of proton stopping powers (PSPs) of traversed tissues. Nowadays, proton treatment planning is based on stopping powers derived from X-ray Computed Tomography (CT) images leading to systematic uncertainties in the proton range in a patient of 3 –4% and even up to 10% in regions containing bone. This may cause no dose in parts of the tumor and overdose in healthy tissues. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - August 27, 2016 Category: Journals (General) Authors: A. Biegun, J. Takatsu, T. Nakaji, M-J. van Goethem, E.R. van der Graaf, E.N. Koffeman, J. Visser, S. Brandenburg Source Type: research

Advances in hadrontherapy dosimetry
This paper investigates suitability of two new commercial solid-state detectors as alternative to reference detectors for dosimetry of proton and carbon ion beams, as for scattered and scanned beams.Investigated detectors are PTW microDiamond and PTW PR 60020 diode that have very small measuring volume with extremely reduced thickness of active detector layer (1m for diamond, 20m for diode).Both detectors were tested in 62MeV ocular proton therapy beam (INFN-LNS), PTW microdiamond was tested in clinical scanned carbon ion beams up to 400MeV/u (CNAO), PTW PR 60020 Dosimetry was tested in scanned proton beams up to 250MeV (C...
Source: Physica Medica: European Journal of Medical Physics - August 27, 2016 Category: Journals (General) Authors: L. Raffaele Source Type: research

The future role of particle beams in the treatment of pediatric tumours, by a medical physics point of view
Proton therapy, as compared to standard photon radiotherapy, presents the advantage of sparing non-target tissue. This is especially important for treatments of paediatric patients, where the reduction of integral dose and dose to organs at risk can significantly improve children ’s quality of life, while reducing the risk for late toxicity, not limited but including secondary malignancies.Cranio-spinal irradiation with protons represents a good example of reduced integral dose, as the dose to all anatomical structures anterior to the spinal cord (such as kidneys, heart, l iver) are reduced when compared to photon tr...
Source: Physica Medica: European Journal of Medical Physics - August 27, 2016 Category: Journals (General) Authors: A. Bolsi, T. Lomax, D.C. Weber Source Type: research

Expected clinical benefits and challenges of particle therapy for paediatric tumours
Proton therapy for non-ocular tumours in children is a relatively new development in Europe. Main arguments for proton therapy are the reduced risk for secondary cancers as well as a more precise sparing of organs at risk (OAR).Due to interdisciplinary advances more children survive their childhood cancer and have to deal with late effects of their primary cancer treatment.Children are by about a factor of ten more sensitive to radiation-induced malignancies than adults. Due to a smaller body volume, the scattering is more significant than in the (larger) body of an adult. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - August 27, 2016 Category: Journals (General) Authors: Solveig Schulz, Felicitas Guntrum, Christian B äumer, Beate Timmermann Source Type: research

Preliminary investigations on the use of MRI for decision making in adaptive proton radiotherapy for head and neck cancer
For proton therapy of head and neck (H&N) virtual CT-scans (VCTs) generated from CBCTs can aid decision making for treatment adaptation. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - August 27, 2016 Category: Journals (General) Authors: Florence Giesen, Luiza Bondar, Benoit Macq Source Type: research

A simple PMMA phantom for daily QA energy checks in proton therapy
Beam energy measurements are one of the most important data that every radiotherapy facility has to collect periodically as constancy check. In proton therapy, due to the energy selection system and to the shape of the Bragg peak, this check has to be performed daily. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - August 27, 2016 Category: Journals (General) Authors: N. Bizzocchi, F. Fracchiolla, M. Schwarz Source Type: research

Pencil beam scanning proton therapy for treatment of the retroperitoneum after nephrectomy for Wilms tumor: A dosimetric comparison study
In this study, we evaluate PBS plans for postoperative irradiation in patients with Wilms tumor. ProcedurePatients were treated with anterior‐posterior–posterior‐anterior (AP–PA) photon fields encompassing the preoperative tumor volume. Patients requiring whole lung irradiation were treated with AP–PA photon fields covering the bilateral lungs. Prescription doses were generally 1,080 and 1,200 cGy, respectively. Flank PBS plans encompassing the ipsilateral retroperitoneum and para‐arotic nodes were generated for dosimetric evaluation. ResultsTreatment records and comparison plans of 11 patients were...
Source: Pediatric Blood and Cancer - August 27, 2016 Category: Cancer & Oncology Authors: Jennifer Vogel, Haibo Lin, Stefan Both, Zelig Tochner, Frank Balis, Christine Hill ‐Kayser Tags: Research Article Source Type: research

NTCP modeling analysis of acute hematologic toxicity in whole pelvic radiation therapy for gynecologic malignancies – A dosimetric comparison of IMRT and spot-scanning proton therapy (SSPT)
Whole pelvic radiation therapy (WPRT) plays an important role in the treatment of gynecologic cancers, especially cervical and endometrial cancers. Conventional WPRT contains approximately 40% of the total body bone marrow (BM) and results in hematologic toxicity (HT) [1]. Concurrent chemoradiotherapy (CCRT) is used to improve treatment outcome. However, adding chemotherapy increases the risk of severe HT. Severe HT is critical issue because it disturbs the execution of treatment on schedule such as interruptions of radiotherapy and holds or stops chemotherapy [2]. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - August 26, 2016 Category: Journals (General) Authors: Takaaki Yoshimura, Rumiko Kinoshita, Shunsuke Onodera, Chie Toramatsu, Ryusuke Suzuki, Yoichi M. Ito, Seishin Takao, Taeko Matsuura, Yuka Matsuzaki, Kikuo Umegaki, Hiroki Shirato, Shinichi Shimizu Tags: Original paper Source Type: research

[Proton therapy].
i D Abstract Proton therapy is an optimized radiotherapy technique. Today, the technical improvement provides reliable machines. The therapeutic indications are clearer even though therapeutic trials should confirm the current guidelines. A better knowledge in radiobiology could be useful if it is integrated in the treatment planning system. A new organization of care will definitively stabilize the number of patients for which treatment will be relevant. This organization will prepare the future expansion of this technique. PMID: 27568293 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 24, 2016 Category: Cancer & Oncology Authors: Noël G, Antoni D Tags: Cancer Radiother Source Type: research

With Gaze Tracking Toward Noninvasive Eye Cancer Treatment
We present a new gaze tracking-based navigation scheme for proton beam radiation of intraocular tumors and we show the technical integration into the treatment facility. Currently, to treat a patient with such a tumor, a medical physicist positions the patient and the affected eye ball such that the radiation beam targets the tumor. This iterative eye positioning mechanism requires multiple X-rays, and radio-opaque clips previously sutured on the target eyeball. We investigate a possibility to replace this procedure with a noninvasive approach using a 3-D model-based gaze tracker. Previous work does not cover a comparably ...
Source: IEEE Transactions on Biomedical Engineering - August 19, 2016 Category: Biomedical Engineering Source Type: research

Neutrons in active proton therapy: Parameterization of dose and dose equivalent.
CONCLUSIONS: The presented neutron dose calculations allow for estimates of dose that can be used in subsequent epidemiological studies or, should the need arise, to estimate the neutron dose at any point where a subsequent secondary tumour may occur. It was found that the neutron dose to the patient is heavily increased with proton energy. PMID: 27524678 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Medizinische Physik)
Source: Zeitschrift fur Medizinische Physik - August 11, 2016 Category: Radiology Authors: Schneider U, Hälg RA, Lomax T Tags: Z Med Phys Source Type: research

Mathematical Optimization of Treatment Schedules
In the past decades, mathematical optimization has found its way into radiation therapy and has had a profound practice-changing impact. Today, virtually all advanced treatment delivery methods, such as intensity modulated radiation therapy (IMRT), volumetric arc therapy, tomotherapy, low-dose-rate/high-dose-rate brachytherapy, and proton therapy are based on some form of optimization approach that changes the treatment variables (eg, beam intensities, multileaf collimator shapes, beam angles, dwell times, and seed or source positions) in the planning computer using an optimization algorithm until the best value of the tre...
Source: International Journal of Radiation Oncology * Biology * Physics - August 5, 2016 Category: Radiology Authors: Bram L. Gorissen, Jan Unkelbach, Thomas R. Bortfeld Tags: Feature Source Type: research

Neutrons in proton pencil beam scanning: parameterization of energy, quality factors and RBE.
x T Abstract The biological effectiveness of neutrons produced during proton therapy in inducing cancer is unknown, but potentially large. In particular, since neutron biological effectiveness is energy dependent, it is necessary to estimate, besides the dose, also the energy spectra, in order to obtain quantities which could be a measure of the biological effectiveness and test current models and new approaches against epidemiological studies on cancer induction after proton therapy. For patients treated with proton pencil beam scanning, this work aims to predict the spatially localized neutron energies, the effe...
Source: Physics in Medicine and Biology - August 3, 2016 Category: Physics Authors: Schneider U, Hälg RA, Baiocco G, Lomax T Tags: Phys Med Biol Source Type: research

Reirradiation of Recurrent and Second Primary Head and Neck Cancer with Proton Therapy
Curative-intent proton reirradiation was employed in 61 patients with mostly skull base recurrent disease of varied histologies, with concurrent chemotherapy in a minority. Despite advanced stage recurrent disease and extensive pretreatment in a population mostly judged unsuitable for reirradiation with other modalities, proton reirradiation yielded reasonable outcomes and toxicities. A cutaneous primary, gross residual disease, increasing gross tumor volume, and a lower dose of radiation were associated with a greater hazard ratio for local failure. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - August 2, 2016 Category: Radiology Authors: Mark W. McDonald, Omid Zolali-Meybodi, Stephen J. Lehnert, Neil C. Estabrook, Yuan Liu, Aaron A. Cohen-Gadol, Michael G. Moore Source Type: research

First in situ TOF-PET study using digital photon counters for proton range verification.
Abstract Positron emission tomography (PET) is the imaging modality most extensively tested for treatment monitoring in particle therapy. Optimal use of PET in proton therapy requires in situ acquisition of the relatively strong (15)O signal due to its relatively short half-life (~2 min) and high oxygen content in biological tissues, enabling shorter scans that are less sensitive to biological washout. This paper presents the first performance tests of a scaled-down in situ time-of-flight (TOF) PET system based on digital photon counters (DPCs) coupled to Cerium-doped Lutetium Yttrium Silicate (LYSO:Ce) cry...
Source: Physics in Medicine and Biology - August 1, 2016 Category: Physics Authors: Cambraia Lopes P, Bauer J, Salomon A, Rinaldi I, Tabacchini V, Tessonnier T, Crespo P, Parodi K, Schaart DR Tags: Phys Med Biol Source Type: research

The Integration of Perianesthesia Certified Nurses into an Ambulatory Specialty Treatment Center
In 2013, the Ambulatory Surgical Center Post Anesthesia Care nurses assumed responsibility for recovering pediatric patients receiving general anesthesia in our Proton Therapy Center (PTC). The Proton Therapy Center is a freestanding ambulatory center with a three bay recovery area. Due to staffing, Magnet and Joint Commission requirements, it was determined that Certified Post Anesthesia Care nurses would be the preferred providers of nursing care. Certified nurses practice in accordance with ASPAN standards and practice recommendations in the care of the anesthetized pediatric patient population. (Source: Journal of PeriAnesthesia Nursing)
Source: Journal of PeriAnesthesia Nursing - July 28, 2016 Category: Nursing Authors: Yvette Rosenthal, Deborah White, Janelle Kister, Leo Flores, Sharon Carson, Jessica Roberts, Sharon Hampton Source Type: research

The World's First Single-Room Proton Therapy Facility - Two-Year Experience
Conclusions The installation of our single gantry proton facility has expanded the treatment options within our cancer center, helping to increase the number of patients we see. Patients travel from twice as far away to receive this treatment, many for typical proton therapy indications such as pediatrics or to participate in prospective clinical trials. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - July 24, 2016 Category: Cancer & Oncology Source Type: research

Which cervical and endometrial cancer patients will benefit most from intensity-modulated proton therapy?
In this dosimetric comparison study it was shown that IMPT with robust planning reduces dose to surrounding organs in cervical and endometrial cancer treatment compared with IMRT. Especially for the para-aortic region, clinically relevant dose reductions were obtained for kidneys, spinal cord and bowel, justifying the use of proton therapy for this indication. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - July 21, 2016 Category: Radiology Authors: Mariska A.E. van de Sande, Carien L. Creutzberg, Steven van de Water, Abdul Wahab Sharfo, Mischa S. Hoogeman Tags: Technical Note Source Type: research

Which cervical and endometrial cancer patients will benefit most from intensity-modulated proton therapy?
Abstract In this dosimetric comparison study it was shown that IMPT with robust planning reduces dose to surrounding organs in cervical and endometrial cancer treatment compared with IMRT. Especially for the para-aortic region, clinically relevant dose reductions were obtained for kidneys, spinal cord and bowel, justifying the use of proton therapy for this indication. PMID: 27452411 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 21, 2016 Category: Radiology Authors: van de Sande MA, Creutzberg CL, van de Water S, Sharfo AW, Hoogeman MS Tags: Radiother Oncol Source Type: research

The Integration of Perianesthesia Certified Nurses into an Ambulatory Specialty Treatment Center
In 2013, the Ambulatory Surgical Center Post Anesthesia Care nurses assumed responsibility for recovering pediatric patients receiving general anesthesia in our Proton Therapy Center (PTC). The Proton Therapy Center is a freestanding ambulatory center with a three bay recovery area. Due to staffing, Magnet and Joint Commission requirements, it was determined that Certified Post Anesthesia Care nurses would be the preferred providers of nursing care. Certified nurses practice in accordance with ASPAN standards and practice recommendations in the care of the anesthetized pediatric patient population. (Source: Journal of PeriAnesthesia Nursing)
Source: Journal of PeriAnesthesia Nursing - July 19, 2016 Category: Nursing Authors: Yvette Rosenthal, Deborah White, Janelle Kister, Leo Flores, Sharon Carson, Jessica Roberts, Sharon Hampton Source Type: research

Sperm preservation and neutron contamination following proton therapy for prostate cancer study.
Abstract BACKGROUND: The present study investigates the impact of scatter dose radiation to the testis on ejaculate and sperm counts from treatment of prostate cancer with passive-scatter proton therapy. MATERIAL AND METHODS: From March 2010 to November 2014, 20 men with low- or intermediate-risk prostate cancer enrolled in an IRB-approved protocol and provided a semen sample prior to passive-scatter proton therapy and 6-12 months following treatment. Men were excluded if they had high-risk prostate cancer, received androgen deprivation therapy, were on alpha blockers (due to retrograde ejaculation) prior to ...
Source: Acta Oncologica - July 15, 2016 Category: Cancer & Oncology Authors: Hoppe BS, Harris S, Rhoton-Vlasak A, Bryant C, Morris CG, Dagan R, Nichols RC, Mendenhall WM, Henderson RH, Li Z, Mendenhall NP Tags: Acta Oncol Source Type: research

Dosimetry intercomparison of four German proton therapy institutions employing spot scanning.
CONCLUSIONS: The match of measured dose and range is better than expected from the respective uncertainties. As all physics teams agree on the assessment of absorbed dose and range, an important prerequisite for a start of joint clinical studies is fulfilled. PMID: 27431974 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Medizinische Physik)
Source: Zeitschrift fur Medizinische Physik - July 15, 2016 Category: Radiology Authors: Bäumer C, Ackermann B, Hillbrand M, Kaiser FJ, Koska B, Latzel H, Lühr A, Menkel S, Timmermann B Tags: Z Med Phys Source Type: research

Modelling of organ-specific radiation-induced secondary cancer risks following particle therapy.
CONCLUSION: Based on the wide spread in RR between patients and variations across the included parameter values, the risk profiles of the rectum and bladder were not dramatically different for the investigated radiotherapy techniques. PMID: 27424291 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 13, 2016 Category: Radiology Authors: Stokkevåg CH, Fukahori M, Nomiya T, Matsufuji N, Engeseth GM, Hysing LB, Ytre-Hauge KS, Rørvik E, Szostak A, Muren LP Tags: Radiother Oncol Source Type: research

Mechanisms of phosphene generation in ocular proton therapy as related to space radiation exposure
Publication date: Available online 7 July 2016 Source:Life Sciences in Space Research Author(s): D. Chuard, V. Anthonipillai, R. Dendale, C. Nauraye, E. Khan, C. Mabit, L. De Marzi, L. Narici Particle therapy provides an opportunity to study the human response to space radiation in ground-based facilities. On this basis, a study of light flashes analogous to astronauts’ phosphenes reported by patients undergoing ocular proton therapy has been undertaken. The influence of treatment parameters on phosphene generation was investigated for 430 patients treated for a choroidal melanoma at the proton therapy cent...
Source: Life Sciences in Space Research - July 8, 2016 Category: Biology Source Type: research

Urethral dose sparing in squamous cell carcinoma of anal canal using proton therapy matching electrons with prior brachytherapy for prostate cancer: A case study
The purpose of this case study is to communicate a technique on treating the re-irradiation of squamous cell carcinoma (SCC) of anal canal with proton fields matched with electron fields to spare prostatic urethra. A 76-year old male presented with a secondary radiation-induced malignancy as a result of prostate brachytherapy seeds irradiation 10 years prior. A rectal examination revealed a bulky tumor at the top of the anal canal involving the left superior-most aspect of the anal canal extending superiorly into the rectum. (Source: Medical Dosimetry)
Source: Medical Dosimetry - July 7, 2016 Category: Radiology Authors: Ontida Apinorasethkul, Nishele Lenards, Ashley Hunzeker Source Type: research

What is the best way to radiate the prostate in 2016?
Abstract Prostate cancer treatment with definitive radiation therapy (RT) has evolved dramatically in the past 2 decades. From the initial 2-dimensional planning using X-rays, advances in technology led to 3-dimensional conformal RT, which used computerized tomography-based planning. This has allowed delivery of higher doses of radiation to the prostate while reducing dose to the surrounding organs, resulting in improved cancer control. Today, intensity-modulated RT (IMRT) is considered standard, where radiation beams of different shapes and intensities can be delivered from a wide range of angles, thus further de...
Source: Urologic Oncology - July 6, 2016 Category: Urology & Nephrology Authors: Moon DH, Efstathiou JA, Chen RC Tags: Urol Oncol Source Type: research

Effects of anatomical changes on pencil beam scanning proton plans in locally advanced NSCLC patients
This study simulates and evaluates these effects in spot-scanning proton therapy for lung cancer patients. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - July 5, 2016 Category: Radiology Authors: Yenny Z. Szeto, Marnix G. Witte, Simon R. van Kranen, Jan-Jakob Sonke, José Belderbos, Marcel van Herk Source Type: research

Effects of anatomical changes on pencil beam scanning proton plans in locally advanced NSCLC patients.
CONCLUSIONS: Daily anatomical variations over the course of treatment can cause considerable dose differences in the robust planned dose distribution. An advanced planning strategy including knowledge of anatomical uncertainties would be recommended to improve plan robustness against interfractional variations. For large anatomical changes, adaptive therapy is mandatory. PMID: 27393217 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 5, 2016 Category: Radiology Authors: Szeto YZ, Witte MG, van Kranen SR, Sonke JJ, Belderbos J, van Herk M Tags: Radiother Oncol Source Type: research

Effects of anatomical changes on pencil beam scanning proton plans in locally advanced NSCLC patients
This study simulates and evaluates these effects in spot-scanning proton therapy for lung cancer patients. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - July 5, 2016 Category: Radiology Authors: Yenny Z. Szeto, Marnix G. Witte, Simon R. van Kranen, Jan-Jakob Sonke, Jos é Belderbos, Marcel van Herk Source Type: research

Dosimetric advantages of proton therapy over conventional radiotherapy with photons in young patients and adults with low-grade glioma
Abstract Background and purpose Low-grade glioma (LGG) is a very common brain tumor in pediatric patients typically associated with a very good prognosis. This prognosis makes it imperative that the risk of long-term treatment-related side effects be kept at an absolute minimum. Proton therapy (PRT) provides a radiation technique that has the potential to further reduce the genesis of radiogenic impairment. Materials and methods We retrospectively assessed 74 patients with LGG who underwent PRT. Conventional three-dimensional photon and PRT plans we...
Source: Strahlentherapie und Onkologie - June 30, 2016 Category: Cancer & Oncology Source Type: research

Limited impact of setup and range uncertainties, breathing motion and interplay effects in robustly optimized intensity modulated proton therapy for stage III non-small cell lung cancer
The effectiveness of robustly optimized intensity modulated proton therapy (IMPT) against setup and range uncertainties, breathing motion, and interplay effects was investigated for treatment plans of advanced stage non-small cell lung cancer. Our study demonstrated that IMPT with robust optimization is a promising technique to limit the impact of these effects on target coverage and dose homogeneity, with minimal effect on organ at risk dose parameters. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - June 29, 2016 Category: Radiology Authors: Tatsuya Inoue, Joachim Widder, Lisanne V. van Dijk, Hideki Takegawa, Masahiko Koizumi, Masaaki Takashina, Keisuke Usui, Chie Kurokawa, Satoru Sugimoto, Anneyuko I. Saito, Keisuke Sasai, Aart A. van’t Veld, Johannes A. Langendijk, Erik W. Korevaar Source Type: research

Limited Impact of Setup and Range Uncertainties, Breathing Motion, and Interplay Effects in Robustly Optimized Intensity Modulated Proton Therapy for Stage III Non-small Cell Lung Cancer
To investigate the impact of setup and range uncertainties, breathing motion, and interplay effects using scanning pencil beams in robustly optimized intensity modulated proton therapy (IMPT) for stage III non-small cell lung cancer (NSCLC). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - June 29, 2016 Category: Radiology Authors: Tatsuya Inoue, Joachim Widder, Lisanne V. van Dijk, Hideki Takegawa, Masahiko Koizumi, Masaaki Takashina, Keisuke Usui, Chie Kurokawa, Satoru Sugimoto, Anneyuko I. Saito, Keisuke Sasai, Aart A. van't Veld, Johannes A. Langendijk, Erik W. Korevaar Tags: Physics Contribution Source Type: research

Intensity-modulated proton therapy, volumetric-modulated arc therapy, and 3D conformal radiotherapy in anaplastic astrocytoma and glioblastoma
Abstract Purpose The prognosis for high-grade glioma (HGG) patients is poor; thus, treatment-related side effects need to be minimized to conserve quality of life and functionality. Advanced techniques such as proton radiation therapy (PRT) and volumetric-modulated arc therapy (VMAT) may potentially further reduce the frequency and severity of radiogenic impairment. Materials and methods We retrospectively assessed 12 HGG patients who had undergone postoperative intensity-modulated proton therapy (IMPT). VMAT and 3D conformal radiotherapy (3D-CRT) plans ...
Source: Strahlentherapie und Onkologie - June 22, 2016 Category: Cancer & Oncology Source Type: research

Protons for Oropharyngeal Cancer Have Not Yet Justified Their Promise
Our colleagues had a tough job to do. Using patient-reported outcomes (PRO) instruments that may have lacked sensitivity to elicit subtle differences in outcomes important to patients, they compared PROs in oropharyngeal cancer patients treated with intensity modulated proton therapy (IMPT) versus those in patients treated with intensity modulated photon therapy (IMRT) (1). Sio et al hypothesized that because IMPT reduces the low-dose bath to the anterior oral cavity, brainstem, and posterior neck, IMPT could result in less symptom burden and better quality of life (QOL). (Source: International Journal of Radiation On...
Source: International Journal of Radiation Oncology * Biology * Physics - June 21, 2016 Category: Radiology Authors: Jonathan J. Beitler, Bhishamjit S. Chera Tags: Clinical Investigation Source Type: research

Evaluation of the relative biological effectiveness of spot-scanning proton irradiation in vitro
Variations in relative biological effectiveness (RBE) from a fixed value of 1.1 are critical in proton beam therapy. To date, studies estimating RBE at multiple positions relative to the spread-out Bragg peak (SOBP) have been predominantly performed using passive scattering methods, and limited data are available for spot-scanning beams. Thus, to investigate the RBE of spot-scanning beams, Chinese hamster fibroblast V79 cells were irradiated using the beam line at the Hokkaido University Hospital Proton Therapy Center. Cells were placed at six different depths, including the entrance of the proton beam and the proximal and...
Source: Journal of Radiation Research - June 21, 2016 Category: Physics Authors: Maeda, K., Yasui, H., Matsuura, T., Yamamori, T., Suzuki, M., Nagane, M., Nam, J.-M., Inanami, O., Shirato, H. Tags: Short communication Source Type: research

Intensity-modulated proton beam therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for patients with oropharynx cancer – A case matched analysis
Owing to its physical properties, intensity-modulated proton therapy (IMPT) used for patients with oropharyngeal carcinoma has the ability to reduce the dose to organs at risk compared to intensity-modulated radiotherapy (IMRT) while maintaining adequate tumor coverage. Our aim was to compare the clinical outcomes of these two treatment modalities. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - June 21, 2016 Category: Radiology Authors: Pierre Blanchard, Adam S. Garden, G. Brandon Gunn, David I. Rosenthal, William H. Morrison, Mike Hernandez, Joseph Crutison, Jack J. Lee, Rong Ye, C. David Fuller, Abdallah S.R. Mohamed, Kate A. Hutcheson, Emma B. Holliday, Nikhil G. Thaker, Erich M. Stur Tags: Original article Source Type: research

Intensity-modulated proton beam therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for patients with oropharynx cancer - A case matched analysis.
CONCLUSION: Our results suggest that IMPT is associated with reduced rates of feeding tube dependency and severe weight loss without jeopardizing outcome. Prospective multicenter randomized trials are needed to validate such findings. PMID: 27342249 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 21, 2016 Category: Radiology Authors: Blanchard P, Garden AS, Gunn GB, Rosenthal DI, Morrison WH, Hernandez M, Crutison J, Lee JJ, Ye R, Fuller CD, Mohamed AS, Hutcheson KA, Holliday EB, Thaker NG, Sturgis EM, Kies MS, Zhu XR, Mohan R, Frank SJ Tags: Radiother Oncol Source Type: research

Intensity-modulated proton beam therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for patients with oropharynx cancer – A case matched analysis
Owing to its physical properties, intensity-modulated proton therapy (IMPT) used for patients with oropharyngeal carcinoma has the ability to reduce the dose to organs at risk compared to intensity-modulated radiotherapy (IMRT) while maintaining adequate tumor coverage. Our aim was to compare the clinical outcomes of these two treatment modalities. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - June 21, 2016 Category: Radiology Authors: Pierre Blanchard, Adam S. Garden, G. Brandon Gunn, David I. Rosenthal, William H. Morrison, Mike Hernandez, Joseph Crutison, Jack J. Lee, Rong Ye, C. David Fuller, Abdallah S.R. Mohamed, Kate A. Hutcheson, Emma B. Holliday, Nikhil G. Thaker, Erich M. Stur Tags: Original article Source Type: research

Investigating the Role of Hypothalamic Tumor Involvement in Sleep and Cognitive Outcomes Among Children Treated for Craniopharyngioma
Conclusion: Routine screening for sleep problems during therapy is indicated for children with craniopharyngioma, to optimize the timing of interventions and reduce long-term morbidity. (Source: Journal of Pediatric Psychology)
Source: Journal of Pediatric Psychology - June 20, 2016 Category: Pediatrics Authors: Jacola, L. M., Conklin, H. M., Scoggins, M. A., Ashford, J. M., Merchant, T. E., Mandrell, B. N., Ogg, R. J., Curtis, E., Wise, M. S., Indelicato, D. J., Crabtree, V. M. Tags: Regular Articles Source Type: research

Comparison of outcomes and toxicities among radiation therapy treatment options for prostate cancer
For prostate cancer, radiation therapy options include external beam and brachytherapy.We compare the following radiation therapy modalities for prostate cancer using evidence grading: conventional fractionation, hypofractionation, stereotactic body radiation therapy, proton therapy, low dose rate brachytherapy, high dose rate brachytherapy, and brachytherapy boost.Outcomes and toxicity profiles of the modalities are juxtaposed.Contraindications of options are provided, based on current randomized trials. (Source: Cancer Treatment Reviews)
Source: Cancer Treatment Reviews - June 17, 2016 Category: Cancer & Oncology Authors: Nicholas G Zaorsky, Talha Shaikh, Colin T Murphy, Mark A Hallman, Shelly B Hayes, Mark L Sobczak, Eric M Horwitz Source Type: research

Review of photon and proton radiotherapy for skull base tumours
Publication date: July–August 2016 Source:Reports of Practical Oncology & Radiotherapy, Volume 21, Issue 4 Author(s): Piero Fossati, Andrea Vavassori, Letizia Deantonio, Eleonora Ferrara, Marco Krengli, Roberto Orecchia An extremely large variety of benign and malignant tumours occur at skull base; these tumour lesions are in the proximity to structures deputed to relevant physiologic functions, limiting extensive surgical approaches to this body district. Most recent progresses of surgery and radiotherapy have allowed to improve local control with acceptable rates of side effects. Various photon radi...
Source: Reports of Practical Oncology and Radiotherapy - June 16, 2016 Category: Cancer & Oncology Source Type: research

Cr-09 * quality-of-life after pencil beam scanning proton therapy for pediatric craniopharyngioma patients treated at paul scherrer institute
(Source: Neuro-Oncology)
Source: Neuro-Oncology - June 12, 2016 Category: Cancer & Oncology Authors: Weber, D. C., Pica, A., Teske, C., Kliebsch, U., Schneider, R., Baust, K., Calaminus, G., Timmermann, B. Tags: CRANIOPHARYNGIOMA Source Type: research

Mb-105 * the early outcomes of proton therapy for medulloblastoma on the pediatric proton consortium registry
(Source: Neuro-Oncology)
Source: Neuro-Oncology - June 12, 2016 Category: Cancer & Oncology Authors: Chang, A., Yock, T., Pai, A. Tags: MEDULLOBLASTOMA Source Type: research

Ro-07 * single institution outcomes following proton therapy for united kingdom children with central nervous system tumors referred overseas
(Source: Neuro-Oncology)
Source: Neuro-Oncology - June 12, 2016 Category: Cancer & Oncology Authors: Indelicato, D. J., Bradley, J. A., Rotondo, R. L., Hall, M. D., Gains, J. E., Sandler, E. S., Aldana, P. R., Morris, C. G., Mendenhall, N. P. Tags: RADIATION ONCOLOGY Source Type: research

Ro-11 * decreased incidence of hypothyroidism after craniospinal irradiation (csi) with proton therapy (prt) in patients with medulloblastoma
(Source: Neuro-Oncology)
Source: Neuro-Oncology - June 12, 2016 Category: Cancer & Oncology Authors: Bielamowicz, K., Okcu, M. F., Sonabend, R., Mahajan, A., Paulino, A. C., Adesina, A., Dauser, R., Chintagumpala, M. Tags: RADIATION ONCOLOGY Source Type: research

Ro-17 * initial experience with spot scanning proton therapy for pediatric cns tumors at proton therapy center in trento-italy
(Source: Neuro-Oncology)
Source: Neuro-Oncology - June 12, 2016 Category: Cancer & Oncology Authors: Rombi, B., Vennarini, S., Meneghello, L., Bonazza, C., Pedrotti, D., Dipalma, A., Menegotti, L., Amichetti, M. Tags: RADIATION ONCOLOGY Source Type: research