Combined RBE and OER optimization in proton therapy with FLUKA based on EF5-PET
CONCLUSION: The FLUKA MC based tool was able to optimize proton treatment plans taking the tumor pO2 distribution from hypoxia PET images into account. Independent of RBE-model, both elevated LET and physical dose were found in the hypoxic regions, which shows the potential to increase the tumor control compared to a conventional optimization approach.PMID:37161820 | DOI:10.1002/acm2.14014 (Source: Cancer Control)
Source: Cancer Control - May 10, 2023 Category: Cancer & Oncology Authors: Helge Henjum Tordis Johnsen Dahle Andrea Mairani Sara Pilskog Camilla Stokkev åg Camilla Grindeland Boer Kathrine R øe Redalen Heikki Minn Eirik Malinen Kristian Smeland Ytre-Hauge Source Type: research
Combined RBE and OER optimization in proton therapy with FLUKA based on EF5-PET
CONCLUSION: The FLUKA MC based tool was able to optimize proton treatment plans taking the tumor pO2 distribution from hypoxia PET images into account. Independent of RBE-model, both elevated LET and physical dose were found in the hypoxic regions, which shows the potential to increase the tumor control compared to a conventional optimization approach.PMID:37161820 | DOI:10.1002/acm2.14014 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - May 10, 2023 Category: Physics Authors: Helge Henjum Tordis Johnsen Dahle Andrea Mairani Sara Pilskog Camilla Stokkev åg Camilla Grindeland Boer Kathrine R øe Redalen Heikki Minn Eirik Malinen Kristian Smeland Ytre-Hauge Source Type: research
Evaluating the effect of setup uncertainty reduction and adaptation to geometric changes on normal tissue complication probability using online adaptive head and neck intensity modulated proton therapy
Phys Med Biol. 2023 May 10. doi: 10.1088/1361-6560/acd433. Online ahead of print.ABSTRACTTo evaluate the impact of setup uncertainty reduction (SUR) and adaptation to geometrical changes (AGC) on normal tissue complication probability (NTCP) when using online adaptive head and neck intensity modulated proton therapy (IMPT).

Approach: A cohort of ten retrospective head and neck cancer patients with daily scatter corrected cone-beam CT (CBCT) was studied. For each patient, two IMPT treatment plans were created: one with a 3-mm setup uncertainty robustness setting and one with no explicit setup robustness. Bo...
Source: Physics in Medicine and Biology - May 10, 2023 Category: Physics Authors: Arthur Lalonde Mislav Bobic Gregory C Sharp Ibrahim Chamseddine Brian A Winey Harald Paganetti Source Type: research
Double scattering and pencil beam scanning Monte Carlo workflows for proton therapy retrospective studies on radiation-induced toxicities
CONCLUSION: The results demonstrate that the Monte Carlo method can be used to independently validate a TPS calculation, and to estimate LET distributions. The features of the in-house tool can be used to correlate LET and RBE-weighted dose distributions with the incidence of radiation-induced toxicities following proton therapy treatments.PMID:37164897 | DOI:10.1016/j.canrad.2023.02.001 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 10, 2023 Category: Cancer & Oncology Authors: A M M Leite A Bonfrate A Da Fonseca P Lansonneur C Alapetite H Mammar L De Marzi Source Type: research
Evaluating the effect of setup uncertainty reduction and adaptation to geometric changes on normal tissue complication probability using online adaptive head and neck intensity modulated proton therapy
Phys Med Biol. 2023 May 10. doi: 10.1088/1361-6560/acd433. Online ahead of print.ABSTRACTTo evaluate the impact of setup uncertainty reduction (SUR) and adaptation to geometrical changes (AGC) on normal tissue complication probability (NTCP) when using online adaptive head and neck intensity modulated proton therapy (IMPT).

Approach: A cohort of ten retrospective head and neck cancer patients with daily scatter corrected cone-beam CT (CBCT) was studied. For each patient, two IMPT treatment plans were created: one with a 3-mm setup uncertainty robustness setting and one with no explicit setup robustness. Bo...
Source: Physics in Medicine and Biology - May 10, 2023 Category: Physics Authors: Arthur Lalonde Mislav Bobic Gregory C Sharp Ibrahim Chamseddine Brian A Winey Harald Paganetti Source Type: research
Double scattering and pencil beam scanning Monte Carlo workflows for proton therapy retrospective studies on radiation-induced toxicities
CONCLUSION: The results demonstrate that the Monte Carlo method can be used to independently validate a TPS calculation, and to estimate LET distributions. The features of the in-house tool can be used to correlate LET and RBE-weighted dose distributions with the incidence of radiation-induced toxicities following proton therapy treatments.PMID:37164897 | DOI:10.1016/j.canrad.2023.02.001 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 10, 2023 Category: Cancer & Oncology Authors: A M M Leite A Bonfrate A Da Fonseca P Lansonneur C Alapetite H Mammar L De Marzi Source Type: research
Detectability of anatomical changes with prompt-gamma imaging: First systematic evaluation of clinical application during prostate-cancer proton therapy: Detectability of anatomical changes with PGI
CONCLUSION: For the first time, evidence of the detection capability of anatomical changes in prostate-cancer PT from clinically acquired PGI data is shown. This emphasizes the benefit of PGI-based range verification and demonstrates its potential for online-adaptive PT.PMID:37160193 | DOI:10.1016/j.ijrobp.2023.05.002 (Source: Cancer Control)
Source: Cancer Control - May 9, 2023 Category: Cancer & Oncology Authors: Jonathan Berthold Julian Pietsch Nick Piplack Chirasak Khamfongkhruea Julia Thiele Tobias H ölscher Guillaume Janssens Julien Smeets Erik Traneus Steffen L öck Kristin St ützer Christian Richter Source Type: research
Nephro-oncology: clinical and biochemical aspects of kidney disease and cancer
This article focuses on acute kidney injury (AKI), chronic kidney disease (CKD), various electrolyte and acid-base disorders, the most common cancers after kidney transplantation and the kidney disorders associated with HSCT (hematopoietic stem cell transplantation). The possibility of the application of novel cancer therapy, such as cancer immunotherapy and proton therapy in transplant recipients was also discussed.PMID:37159995 | DOI:10.18388/abp.2020_6588 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - May 9, 2023 Category: Biochemistry Authors: Slawomir Lizakowski Alicja D ębska-Ślizień Ilona Kurnatowska Maciej Jan Zaucha Marcin Matuszewski Beata Naumnik Marcin Adamczak Jerzy Chudek Magdalena Durlik Carla Ferr ándiz-Pulido Bartosz Foroncewicz Ryszard Gellert Magdalena Krajewska Micha ł Nowi Source Type: research
Neurocognitive outcomes in pediatric brain tumors after treatment with proton versus photon radiation: a systematic review and meta-analysis
CONCLUSIONS: Pediatric brain tumor patients who receive PBRT achieve significantly higher scores on most neurocognitive outcomes than those who receive XRT. Larger studies with long-term follow-ups are needed to confirm these results.PMID:37154861 | DOI:10.1007/s12519-023-00726-6 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 8, 2023 Category: Pediatrics Authors: Álvaro Lassaletta Javier S Morales Pedro L Valenzuela Borja Esteso Lisa S Kahalley Donald J Mabbott Soumya Unnikrishnan Elena Panizo Felipe Calvo Source Type: research
Neurocognitive outcomes in pediatric brain tumors after treatment with proton versus photon radiation: a systematic review and meta-analysis
CONCLUSIONS: Pediatric brain tumor patients who receive PBRT achieve significantly higher scores on most neurocognitive outcomes than those who receive XRT. Larger studies with long-term follow-ups are needed to confirm these results.PMID:37154861 | DOI:10.1007/s12519-023-00726-6 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 8, 2023 Category: Pediatrics Authors: Álvaro Lassaletta Javier S Morales Pedro L Valenzuela Borja Esteso Lisa S Kahalley Donald J Mabbott Soumya Unnikrishnan Elena Panizo Felipe Calvo Source Type: research
Neurocognitive outcomes in pediatric brain tumors after treatment with proton versus photon radiation: a systematic review and meta-analysis
CONCLUSIONS: Pediatric brain tumor patients who receive PBRT achieve significantly higher scores on most neurocognitive outcomes than those who receive XRT. Larger studies with long-term follow-ups are needed to confirm these results.PMID:37154861 | DOI:10.1007/s12519-023-00726-6 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 8, 2023 Category: Pediatrics Authors: Álvaro Lassaletta Javier S Morales Pedro L Valenzuela Borja Esteso Lisa S Kahalley Donald J Mabbott Soumya Unnikrishnan Elena Panizo Felipe Calvo Source Type: research
Neurocognitive outcomes in pediatric brain tumors after treatment with proton versus photon radiation: a systematic review and meta-analysis
CONCLUSIONS: Pediatric brain tumor patients who receive PBRT achieve significantly higher scores on most neurocognitive outcomes than those who receive XRT. Larger studies with long-term follow-ups are needed to confirm these results.PMID:37154861 | DOI:10.1007/s12519-023-00726-6 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 8, 2023 Category: Pediatrics Authors: Álvaro Lassaletta Javier S Morales Pedro L Valenzuela Borja Esteso Lisa S Kahalley Donald J Mabbott Soumya Unnikrishnan Elena Panizo Felipe Calvo Source Type: research
Neurocognitive outcomes in pediatric brain tumors after treatment with proton versus photon radiation: a systematic review and meta-analysis
CONCLUSIONS: Pediatric brain tumor patients who receive PBRT achieve significantly higher scores on most neurocognitive outcomes than those who receive XRT. Larger studies with long-term follow-ups are needed to confirm these results.PMID:37154861 | DOI:10.1007/s12519-023-00726-6 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 8, 2023 Category: Pediatrics Authors: Álvaro Lassaletta Javier S Morales Pedro L Valenzuela Borja Esteso Lisa S Kahalley Donald J Mabbott Soumya Unnikrishnan Elena Panizo Felipe Calvo Source Type: research
Neurocognitive outcomes in pediatric brain tumors after treatment with proton versus photon radiation: a systematic review and meta-analysis
CONCLUSIONS: Pediatric brain tumor patients who receive PBRT achieve significantly higher scores on most neurocognitive outcomes than those who receive XRT. Larger studies with long-term follow-ups are needed to confirm these results.PMID:37154861 | DOI:10.1007/s12519-023-00726-6 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 8, 2023 Category: Pediatrics Authors: Álvaro Lassaletta Javier S Morales Pedro L Valenzuela Borja Esteso Lisa S Kahalley Donald J Mabbott Soumya Unnikrishnan Elena Panizo Felipe Calvo Source Type: research
Neurocognitive outcomes in pediatric brain tumors after treatment with proton versus photon radiation: a systematic review and meta-analysis
CONCLUSIONS: Pediatric brain tumor patients who receive PBRT achieve significantly higher scores on most neurocognitive outcomes than those who receive XRT. Larger studies with long-term follow-ups are needed to confirm these results.PMID:37154861 | DOI:10.1007/s12519-023-00726-6 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 8, 2023 Category: Pediatrics Authors: Álvaro Lassaletta Javier S Morales Pedro L Valenzuela Borja Esteso Lisa S Kahalley Donald J Mabbott Soumya Unnikrishnan Elena Panizo Felipe Calvo Source Type: research
