[Erratum to "Delineation of the primary tumour clinical target volumes and neck node levels selection of parotid cancers" [Cancer Radiother. 23 (2019) 255-263]].
[Erratum to "Delineation of the primary tumour clinical target volumes and neck node levels selection of parotid cancers" [Cancer Radiother. 23 (2019) 255-263]]. Cancer Radiother. 2019 Jul 03;: Authors: Piram L, Frédéric-Moreau T, Bellini R, Martin F, Miroir J, Saroul N, Pham Dang N, Biau J, Lapeyre M PMID: 31279441 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 3, 2019 Category: Cancer & Oncology Authors: Piram L, Frédéric-Moreau T, Bellini R, Martin F, Miroir J, Saroul N, Pham Dang N, Biau J, Lapeyre M Tags: Cancer Radiother Source Type: research

Protontherapy versus best photon for mediastinal Hodgkin lymphoma: Dosimetry comparison and treatment using ILROG guidelines.
va YM Abstract The purpose of this work was reducing treatment-related toxicity for Hodgkin lymphomas using practical procedure inspired by the ILROG guidelines. Reporting the first case of localized Hodgkin lymphoma treated with protontherapy in France. A 24-year-old female with mediastinal, bulky, localized, mixed-cellularity, classic Hodgkin lymphoma required an involved-site radiation therapy after complete response following polychemotherapy. Three-dimensional conformal radiation therapy was not acceptable due to high doses to breasts, heart and lungs. We realized a four-dimensional computed tomography (CT) t...
Source: Cancer Radiotherapie - June 27, 2019 Category: Cancer & Oncology Authors: Abbassi LM, Goudjil F, Arsène-Henry A, Dendale R, Kirova YM Tags: Cancer Radiother Source Type: research

Image-guided high-dose-rate interstitial brachytherapy boost in the radical radiotherapy for a huge metastatic carcinoma of cervical lymph nodes from an unknown primary site.
Abstract The purpose of this article was to report the treatment effect of image-guided high-dose-rate interstitial brachytherapy boost in the radical radiotherapy for a huge metastatic carcinoma of cervical lymph nodes from an unknown primary site. The patient was a 75-year-old male. A diagnostic biopsy showed metastatic squamous cell carcinoma and the tumour size was 7.5×6.5×11.5cm3 before treatment (N3; AJCC 7th). After external beam radiotherapy with a dose of 60Gy in 30 fractions, the residual tumour (6.2×4.7×6.0cm3) was treated with image-guided high-dose-rate interstitial brachythera...
Source: Cancer Radiotherapie - June 26, 2019 Category: Cancer & Oncology Authors: Wang M, Wu N, Han D, Zhao H, Cheng G Tags: Cancer Radiother Source Type: research

The German Hodgkin Study Group risk model is useful for Hodgkin lymphoma patients receiving radiotherapy after autologous stem cell transplant.
CONCLUSION: The adoption of the GHSG risk model at the time of recurrence/progression is a useful prognostic tool to select patients with Hodgkin lymphoma for consolidative involved-field radiotherapy after autologous stem cell transplantation. PMID: 31178272 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 6, 2019 Category: Cancer & Oncology Authors: Furlan C, Matrone F, Rupolo M, Ciancia R, Zanet E, Montante B, Palazzari E, Navarria F, Trovo M, Bulian P, Spina M, Coassin E, Mascarin M, De Paoli A, Franchin G, Michieli M Tags: Cancer Radiother Source Type: research

Radiation recall syndrome in a patient with breast cancer, after introduction of everolimus.
We report a case of radiation recall syndrome in a breast cancer patient, after introduction of everolimus. A woman with a right breast cancer underwent a mastectomy, then adjuvant chemotherapy, radiation therapy and hormonotherapy. In a phase III trial (UNIRAD protocol), she received everolimus 5 months after radiation therapy. Seven days after introduction, she was suffering from a radiation recall syndrome with exacerbation skin reactions. The exact pathophysiological mechanism of radiation recall syndrome is unknown. The combination of radiation therapy and mTor inhibitor, even sequentially, should be done with caution...
Source: Cancer Radiotherapie - June 5, 2019 Category: Cancer & Oncology Authors: Visy A, Bachelot T, Racadot S Tags: Cancer Radiother Source Type: research

[Digital applicator by 3D printing in contact brachytherapy].
We present the technical implementation of this method for our first two patients. A provisional planning scanner was carried out to create a digital applicator. The creation of the digital applicator used successively several software programs. The first, commercial, was RhinocerosR 3D used via Grasshopper, an integrated open source plug-in. The 3D applicator was then exported to the commercial software Simplify3DR. A g-code format file was generated for the printer. A second scanner was made with a 3D applicator in place to plan the final treatment. The treatment was planned by reverse optimization. The applicator could ...
Source: Cancer Radiotherapie - May 30, 2019 Category: Cancer & Oncology Authors: Lecornu M, Silva M, Barraux V, Stefan D, Kao W, Thariat J, Loiseau C Tags: Cancer Radiother Source Type: research

[Stereotactic body radiotherapy: Prospective study to evaluate asthenia and quality of life].
Abstract PURPOSE: To evaluate prospectively asthenia and the quality of life in patients treated by stereotactic body irradiation and to determine their predictive factors. METHODS AND MATERIALS: Quality of life was assessed by the EORTC QLQ-C30 and asthenia was evaluated with the Brief Fatigue Inventory (BFI), on the first day (T1), last day (T2) and 1-3 weeks after the end of treatment (T3). RESULTS: Sixty-three patients were treated with stereotactic body irradiation from February 2017 to May 2017 and 41 were included in the analysis (22 patients excluded for lack of understanding, organization, psych...
Source: Cancer Radiotherapie - May 29, 2019 Category: Cancer & Oncology Authors: Abbassi LM, Laurans M, Gasnier A, Smulevici A, Tournat H, Bibault JE, Huertas A, Jouglar E, Suissa A, Kreps S, Giraud P, Durdux C Tags: Cancer Radiother Source Type: research

[Limits of technique: Ethical issues].
Abstract Radiation oncology departments are paradigmatic examples of the general evolution of medicine towards an ever more important presence of technology. The distance to the body or our radical dependence on the machine are concrete factors conditioning care practices in radiotherapy. Thus, an essential question appears: can technique be seen as a real limit for our primary function of care in radiation oncology? It is also necessary to consider the postures this question could lead to: the real risk of finding legitimacy in our sole function of technicians. If technique can be seen as a possible hindrance to ...
Source: Cancer Radiotherapie - May 28, 2019 Category: Cancer & Oncology Authors: Haaser T Tags: Cancer Radiother Source Type: research

[Radiotherapy treatment planning of prostate cancer using magnetic resonance imaging].
CONCLUSION: The dose calculated using the pseudo-CT is very close to the dose calculated using the CT for both organs at risk and PTV. These results confirm that pseudo-CT images generated using the proposed method could be used to calculate radiotherapy treatment doses on MRI images. PMID: 31151816 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 28, 2019 Category: Cancer & Oncology Authors: Vanquin L, Boydev C, Korhonen J, Rault E, Crop F, Lacornerie T, Wagner A, Laffarguette J, Pasquier D, Reynaert N Tags: Cancer Radiother Source Type: research

[Radiation-induced head and neck pain: Management with botulinum toxin a injections].
Abstract PURPOSE: To report the results of Botulinum Toxin A (BTA) for radiation-induced head and neck pain. MATERIALS AND METHODS: This single-center retrospective study included all the patients treated at our institution with botulinum toxin A injections for radiation-induced head and neck pain between 2006 and 2017. Pain was evaluated by each patient on a visual analogue scale (VAS) (between 0 and 10) before, and 1 month after the injection. RESULTS: Sixteen patients were included in this series. The mean value of the pain was 8.5 before and 8 after the first injection. The difference was statistically significant (p
Source: Cancer Radiotherapie - May 27, 2019 Category: Cancer & Oncology Authors: Mailly M, Benzakin S, Chauvin A, Brasnu D, Ayache D Tags: Cancer Radiother Source Type: research

Radiotherapy in combination with nivolumab for relapsed/refractory classical Hodgkin lymphoma: About two cases.
va YM Abstract Hodgkin lymphoma is a highly curable malignancy involving lymph nodes and the lymphatic system. Even at late stage disease, about 70% of patients will be cured with standard first line therapy. For patients who experience relapse or refractory classical Hodgkin lymphoma, the standard treatment option is high-dose chemotherapy followed by autologous stem cell rescue or transplant. However about 50% of patients will have recurrence after high-dose chemotherapy followed by autologous stem cell rescue or transplantation and have worse prognosis with median overall survival of 32% at 5 years. The anti-PD...
Source: Cancer Radiotherapie - May 27, 2019 Category: Cancer & Oncology Authors: de Forceville L, Deau-Fischer B, Franchi P, Arsène-Henry A, Cassou Mounat T, Bouscary D, Kirova YM Tags: Cancer Radiother Source Type: research

[Boost in proton for locally advanced nasopharyngeal carcinoma: A Curie Institute experience].
CONCLUSION: This study showed that a complementary dose with proton seems to be a good option for the treatment of locally advanced nasopharyngeal carcinoma, particularly for T4N0M0. PMID: 31138519 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 25, 2019 Category: Cancer & Oncology Authors: Beddok A, Feuvret L, Noël G, Bolle S, Deberne M, Mammar H, Chaze A, Le Tourneau C, Goudjil F, Zefkili S, Herman P, Dendale R, Calugaru V Tags: Cancer Radiother Source Type: research

[Toxicity of docetaxel, platine, 5-fluorouracil-based induction chemotherapy for locally advanced head and neck cancer: The importance of nutritional status].
CONCLUSION: Induction chemotherapy by TPF has an strong anti-tumor efficacy (75.5% objective response) but an important morbidity with 10% toxic deaths in our very symptomatic population with a very important tumor burden. Age and nutritional status are important factors to consider. PMID: 31138520 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 25, 2019 Category: Cancer & Oncology Authors: Bernadach M, Lapeyre M, Dillies AF, Miroir J, Moreau J, Kwiatkowski F, Pham-Dang N, Saroul N, Durando X, Biau J Tags: Cancer Radiother Source Type: research

Stereotactic radiotherapy in targeted therapy treated oligo-metastatic oncogene-addicted (non-small-cell) lung cancer.
Abstract While the prognosis of metastatic non-small-cell lung cancer has shown significant progress these last years, notably with the discovery of oncogen-driven subtypes and the development of targeted therapies, significant improvements are still needed. More recently, numerous authors studied the oligo-metastasis concept, where the metastasis are limited in number and sites involved, and that could benefit from an aggressive approach of these lesions, for instance with the help of stereotactic radiotherapy. Nevertheless, there is no clear consensus existing for the time being for the treatment of these tumors...
Source: Cancer Radiotherapie - May 24, 2019 Category: Cancer & Oncology Authors: Giraud N, Abdiche S, Trouette R Tags: Cancer Radiother Source Type: research

Relationship between nutritional status and esophageal fistula formation after radiotherapy for esophageal cancer.
CONCLUSION: In patients with esophageal cancer treated with definitive radiotherapy, a BMI below20kg/m2 is a risk factor for esophageal fistula formation. A well-designed randomized controlled trial comparing the incidence of esophageal fistulas between patients with esophageal cancer who do and do not receive nutritional support before radiotherapy is required. PMID: 31133512 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 24, 2019 Category: Cancer & Oncology Authors: Watanabe S, Ogino I, Kunisaki C, Hata M Tags: Cancer Radiother Source Type: research

[From bunker construction to patient treatment: quality controls applied to modern radiotherapy techniques].
ier I Abstract Installation and use of a new radiotherapy device require an adequate quality and safety policy. The process leading to the commissioning of an accelerator following the construction of a bunker includes, among other tasks, the installation of the accelerator, the verification of compliance with the specifications, the signature of the acceptance specification as well as the process of characterization and modeling of the accelerator before its clinical use. The emergence of modern radiotherapy techniques, such as intensity modulated conformational radiotherapy and stereotactic radiotherapy, has res...
Source: Cancer Radiotherapie - May 24, 2019 Category: Cancer & Oncology Authors: Klausner G, Blais E, Martin C, Biau J, Jumeau R, Canova CH, Lyothier A, Slama Y, Jenny C, Chéa M, Zilli T, Miralbell R, Thariat J, Maingon P, Troussier I Tags: Cancer Radiother Source Type: research

An MRI comparative image evaluation under diagnostic and radiotherapy planning set-ups using a carbon fibre tabletop for pelvic radiotherapy.
CONCLUSIONS: SNR, CNR and image quality were significantly worse when using the RT-set-up than with the DX-set-up although Image quality in the RT-set-up was acceptable. PMID: 31133514 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 24, 2019 Category: Cancer & Oncology Authors: Sabater S, Pastor-Juan MR, Berenguer R, Lozano-Setien E, Andres I, Tercero-Azorin MI, Sevillano M, Jimenez-Jimenez E, Rovirosa A, Korte E, Arenas M Tags: Cancer Radiother Source Type: research

[Skull base meningioma: Clinical and radiological efficacy based on a quantitative volumetric analysis].
The objective of this work is to verify this hypothesis by quantitative volumetric analysis. MATERIAL AND METHODS: Data from 35 patients treated with either helical tomotherapy (45.7%) or fractionated stereotactic radiotherapy (54.3%) were retrospectively analysed. These were mainly women (94%) aged 59 (43-81) with lesions mainly of the cavernous sinus (60%). There was a median of 2 (1-4) symptoms and the main symptoms were visual impairment (39%), cranial nerve deficits (23.4%) and headaches (17.2%). RESULTS: Median tumour volume decreased significantly (P
Source: Cancer Radiotherapie - May 22, 2019 Category: Cancer & Oncology Authors: Brahimi Y, Antoni D, Srour R, Wagner P, Proust F, Thiery A, Labani A, Noël G Tags: Cancer Radiother Source Type: research

Mucoc èles nasosinusiennes post-radiques à propos de trois cas.
We describe three patients presenting mucocele, with the history of nasopharyngeal and temporal fossa cancers treated by radiotherapy. PMID: 31126746 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 21, 2019 Category: Cancer & Oncology Authors: Jaafoura H, Tbini M, Riahi I, Harhira MR, Ben Salah M Tags: Cancer Radiother Source Type: research

[Which alpha/beta ratio for prostate cancer in 2019?]
nge G Abstract In 1999, Brenner and Hall reported for prostate cancer a very low alpha/beta ratio (1.5Gy). In the following years, this value has been confirmed by a large series of papers, so that this very low alpha/beta ratio became a "dogma", on which a large number of hypofractionated schemes were being built. This was logical, since this very low value strongly suggested a beneficial advantage of hypofractionation for prostate cancer. However, more recently, several questions arose; first, a number of authors reported, from the analysis of their own data, values of alpha/beta ratio which were highe...
Source: Cancer Radiotherapie - May 20, 2019 Category: Cancer & Oncology Authors: Cosset JM, Chargari C, Créhange G Tags: Cancer Radiother Source Type: research

[Use of 4D-CT: Main technical aspects and clinical benefits].
te; N Abstract The four-dimensional scannography, also called 4D-CT, was created in the early 2000s. This method enables the aquistion of CT-scans synchronised with the patient's breathing. It allows an anatomical observation depending on the time. Different systems have been marketed. They are commonly used in treatment planning. It allows to take into account respiratory motion, considering the changes of shape and position of the tumor and organs. In the age of new techniques and stereotactic irradiations, 4D-CT is a valuable tool for estimating the uncertainties associated with respiratory movements, This tech...
Source: Cancer Radiotherapie - May 18, 2019 Category: Cancer & Oncology Authors: Rehailia-Blanchard A, De Oliveira Duarte S, Baury M, Yuan He M, Auberdiac P, Diard A, Brun C, Talabard JN, Rancoule C, Magné N Tags: Cancer Radiother Source Type: research

Twenty years experience in treating childhood medulloblastoma: Between the past and the present.
CONCLUSION: Overall, our results are comparable to those reported in literature. Nevertheless, efforts should be made to ensure longer follow-ups and correctly assess treatment-related toxicity. PMID: 31109839 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 17, 2019 Category: Cancer & Oncology Authors: Khalil J, Qing Z, Chuanying Z, Belkacémi Y, Benjaafar N, Mawei J Tags: Cancer Radiother Source Type: research

Reproducibility of rectal tumor volume delineation using diffusion-weighted MRI: Agreement on volumes between observers.
Abstract PURPOSE: To retrospectively evaluate the inter-observer agreement between a radiologist and a radiation oncologist and volume differences, in T2 and diffusion-weighted (DWI) MRI of gross tumor volume (GTV) delineation, in rectal cancer patients. MATERIALS AND METHODS: Two observers, a radiologist and a radiation oncologist, delineated GTVs of 50 patients on T2-weighted MRI (T2GTV) and echo planar DWI (DWIGTV). Observers agreement was assessed using DICE index, Bland-Altman analysis and intra-class correlation coefficient (ICC). Student's t-test was used for GTV comparison. RESULTS: Median T2GTV ...
Source: Cancer Radiotherapie - May 17, 2019 Category: Cancer & Oncology Authors: Rosa C, Caravatta L, Delli Pizzi A, Di Tommaso M, Cianci R, Gasparini L, Perrotti F, Solmita J, Sartori S, Zecca IAL, Di Nicola M, Basilico R, Genovesi D Tags: Cancer Radiother Source Type: research

A new delineation method research of the clinical target volume for pancreatic cancer adjuvant radiotherapy.
CONCLUSIONS: A majority of postoperative local recurrences in patients with pancreatic head and body cancer are contained within a smaller region surrounding the celiac artery and superior mesenteric artery. The "new" volumes targeting high risk local failures may allow dose escalation and enhanced local control while minimizing radiation-related toxicity. PMID: 31101540 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 14, 2019 Category: Cancer & Oncology Authors: Zhang TT, Wei L, Yuan GW, Zhao DQ, Zhang ML, Zhang GF, Wang PC Tags: Cancer Radiother Source Type: research

[Delineation of the primary tumour clinical target volumes and neck node levels selection of parotid cancers].
This article presents a synthesis of patterns and paths of invasion of parotid glands tumours in order to propose an approach of the delineation of primary tumour clinical target volumes and of the selection of lymph nodes target volumes. This article does not discuss treatment indications but defines clinical target volumes to treat if radiotherapy is indicated. Postoperative situation being the most frequent, the delineation of primary tumour clinical target volume is based on an anatomical approach. PMID: 31101541 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 14, 2019 Category: Cancer & Oncology Authors: Piram L, Frédéric-Moreau T, Bellini R, Martin F, Miroir J, Saroul N, Pham Dang N, Biau J, Lapeyre M Tags: Cancer Radiother Source Type: research

Psychoaffective repercussions of pain in cancer patients.
CONCLUSION: The prevalence of anxiety and depression in our patients was slightly higher than those reported in the literature. The main factors correlated with the onset of depression and anxiety were: severe pain, bone location, and advanced stage of the disease. PMID: 31097369 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 13, 2019 Category: Cancer & Oncology Authors: Khemiri S, Ben Thabet J, Ben Kridis W, Maalej M, Khanfir A, Frikha M Tags: Cancer Radiother Source Type: research

(68Ga)-PSMA-PET/CT for the detection of postoperative prostate cancer recurrence: Possible implications on treatment volumes for radiation therapy.
CONCLUSION: Most of the patients in the present study, presented with distant lymph node and/or bone metastases. Therefore, larger target volumes should be adopted to treat at least 95% of lymph node regions at risk for an occult relapse. PMID: 31088725 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 11, 2019 Category: Cancer & Oncology Authors: De Bari B, Mazzola R, Aiello D, Aloi D, Gatta R, Corradini S, Salgarello M, Alongi F Tags: Cancer Radiother Source Type: research

[Physiopathology and pharmacological perspectives in the treatment of radiation enteritis].
ari C Abstract The small intestine is an organ frequently exposed in abdominal and pelvic irradiations. Acute and late toxicity can sometimes be difficult to manage and can significantly affect the quality of life of patients. Currently there is no guideline on the management of acute and late side effects induced by therapeutic irradiation. The aim of this review is to summarize available data on the pathophysiology of radiation enteritis, and to highlight potential preventive strategies and principles of treatment of radiation enteritis. PMID: 31060972 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 3, 2019 Category: Cancer & Oncology Authors: Rehailia-Blanchard A, He MY, Rancoule C, Vallard A, Espenel S, Nivet A, Magné N, Chargari C Tags: Cancer Radiother Source Type: research

Whole breast radiotherapy in the isocentric lateral decubitus position: Role of the immobilization device and table on clinical results.
CONCLUSIONS: Whole breast radiotherapy in the isocentric lateral decubitus position is well tolerated. Clinical results are comparable based on different immobilization device allowed by linear accelerators. Particularly, there was no influence of the couch on skin tolerance and cosmetic results. PMID: 31053514 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 30, 2019 Category: Cancer & Oncology Authors: Krhili S, Costa E, Xu HP, Kirova YM Tags: Cancer Radiother Source Type: research

Erratum to: "Multidisciplinary treatment approach for primary thyroid spindle cell sarcoma: A case report" [Cancer Radiother. 23 (2019) 46-9].
Erratum to: "Multidisciplinary treatment approach for primary thyroid spindle cell sarcoma: A case report" [Cancer Radiother. 23 (2019) 46-9]. Cancer Radiother. 2019 Apr 05;: Authors: Navarria F, Gigante M, Mascarin M, Italia F, Barresi L, Barzan L, Bertola G, Buonadonna A, Canzonieri V, De Paoli A PMID: 30962080 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 5, 2019 Category: Cancer & Oncology Authors: Navarria F, Gigante M, Mascarin M, Italia F, Barresi L, Barzan L, Bertola G, Buonadonna A, Canzonieri V, De Paoli A Tags: Cancer Radiother Source Type: research

[Left-sided breast cancer locoregional radiation therapy with rotational intensity-modulated irradiation and deep inspiration breath hold: Dosimetric comparison].
CONCLUSION: Rotational intensity-modulated radiotherapy with deep inspiration breath hold is associated with better sparing of the heart, on the right and left anterior descending coronary arteries, and on the aortic valve, compared with free breathing techniques, for adjuvant left breast cancer locoregional irradiation. PMID: 30954386 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 3, 2019 Category: Cancer & Oncology Authors: Fessart É, Crop F, Tresch E, Mirabel X, Lartigau É, Pasquier D Tags: Cancer Radiother Source Type: research

[Stereotactic body radiation therapy for hepatocellular carcinoma: Results from a retrospective multicentre study].
CONCLUSION: Stereotactic body radiation therapy is effective and well-tolerated for inoperable hepatocellular carcinoma or as a bridge to liver transplantation. Toxicity is mainly related to cirrhotic background and requires a selection of patients and strict dose constraints. PMID: 30952560 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 2, 2019 Category: Cancer & Oncology Authors: Scher N, Janoray G, Riet FG, Le Bayon AG, Debbi K, Lévy S, Louisot P, Garaud P, Chajon E, Barillot I, Salamé É, de Crevoisier R, Chapet S, Calais G Tags: Cancer Radiother Source Type: research

Chest wall pain following lung stereotactic body radiation therapy using 48Gy in three fractions: A search for predictors.
CONCLUSION: Our analysis could not find any correlation between the studied parameters and chest wall pain. Considering our present study and the wide range of differing results from the literature, a reasonable conclusion is that a constraint for chest wall pain is yet to be defined. PMID: 30952561 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 2, 2019 Category: Cancer & Oncology Authors: Albers J, Parker W, Kildea J, Pembroke C, Faria S Tags: Cancer Radiother Source Type: research

Patterns of locoregional failure in women with early-stage breast cancer treated by whole breast irradiation in the lateral isocentric decubitus position: Large-scale single-centre experience.
va YM Abstract PURPOSE: The purpose of this study was to evaluate locoregional control and describe the patterns of failure in patients with breast cancer receiving whole breast radiotherapy in the isocentric lateral decubitus position technique. PATIENTS AND METHODS: In a series of 832 consecutive female patients with early-stage breast cancer including invasive and in situ tumours treated by breast-conserving surgery followed by three-dimensional conformal whole breast irradiation in the isocentric lateral decubitus position between 2005 and 2010, all patients who experienced locoregional recurrence were st...
Source: Cancer Radiotherapie - March 29, 2019 Category: Cancer & Oncology Authors: Xu HP, Bronsart E, Costa É, Krhili S, Logerot C, Bazire L, Fournier-Bidoz N, Belshi A, Fourquet A, Kirova YM Tags: Cancer Radiother Source Type: research

Partial versus whole breast irradiation: Side effects, patient satisfaction and costs.
Abstract PURPOSE: Since accelerated partial breast irradiation has demonstrated non-inferiority to whole breast irradiation regarding recurrence rate in patients with early stage breast cancer, our objective was to compare its impact on short-term adverse events, patient satisfaction and costs. MATERIALS AND METHODS: Patients with early stage breast cancer treated by breast-conserving surgery between 2007 and 2012 were included: 48 women who received three-dimensional conformal accelerated partial breast irradiation in a multicentre phase-II trial were paired with 48 patients prospectively treated with whole ...
Source: Cancer Radiotherapie - March 28, 2019 Category: Cancer & Oncology Authors: Bathily T, Borget I, Rivin Del Campo E, Rivera S, Bourgier C Tags: Cancer Radiother Source Type: research

[Effects of high-dose irradiation on vascularization: Physiopathology and clinical consequences].
uet F Abstract A review of the literature has been conducted to better understand the effect of stereotactic radiotherapy on tumour vascularization and their consequences. High irradiation doses cause the death of endothelial cells by apoptosis through the ceramide pathway. Vascular consequences are multiple: increased permeability, decreased blood flow, increased hypoxia and tumoral necrosis. This necrosis causes an indirect death of the cancer cells in the days following the irradiation. The importance of indirect cell death in tumour control remains controversial, but it can explain the good clinical results of...
Source: Cancer Radiotherapie - March 25, 2019 Category: Cancer & Oncology Authors: Nivet A, Schlienger M, Clavère P, Huguet F Tags: Cancer Radiother Source Type: research

[Treatment of patients with brain metastases from a melanoma].
e;, Meyer N Abstract Whereas immune checkpoint inhibitors of serine/threonine protein kinase B-raf therapy dramatically changed metastatic outcomes of patients with melanoma, they remain at high risk of brain extension. Additional local treatment can be offered in this situation such as surgery and or stereotactic radiotherapy. In this review article, we describe the different options with published data and their optimal timing. PMID: 30904418 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 20, 2019 Category: Cancer & Oncology Authors: Modesto A, Chira C, Sol JC, Lubrano V, Boulinguez S, Pagès C, Sibaud V, Gomez-Roca C, Moyal É, Meyer N Tags: Cancer Radiother Source Type: research

[Medical prevention and treatment of radiation-induced urological and nephrological complications].
né N Abstract Abdominal and pelvic irradiations play a major place in the management of patients with cancer and present a risk of acute and late side effects. Radiation-induced lesions can affect kidney or urological structures. These side effects can have an impact in the quality of life of patients. The aim of this article is to describe the physiopathology, the symptomatology, and the principles of management of radiation-induced nephropathy, uretheritis, cystitis, and urethritis. PMID: 30898418 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 18, 2019 Category: Cancer & Oncology Authors: Rehailia-Blanchard A, He MY, Rancoule C, Guillaume É, Guy JB, Vial N, Nivet A, Orliac H, Chargari C, Magné N Tags: Cancer Radiother Source Type: research

Construction and clinical evaluation of a new customized bite block used in radiotherapy of head and neck cancer.
CONCLUSION: A customized bite block is easy-made and worthy of clinical use. PMID: 30898419 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 18, 2019 Category: Cancer & Oncology Authors: Feng Z, Wang P, Gong L, Xu L, Zhang J, Zheng J, Zhang D, Tian T, Wang P Tags: Cancer Radiother Source Type: research

Dose fall-off patterns with volumetric modulated arc therapy and three-dimensional conformal radiotherapy including the "organ at risk" effect. Experience of linear accelerator-based frameless radiosurgery from a single institution.
CONCLUSION: Our study presents the dose fall-off patterns in context of frameless stereotactic radiation therapy. We have presented the dose fall-off data in the framework of three-dimensional conformal radiotherapy and volumetric modulated arc therapy in brain lesions. PMID: 30797691 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - February 20, 2019 Category: Cancer & Oncology Authors: Munshi A, Sarkar B, Roy S, Ganesh T, Mohanti BK Tags: Cancer Radiother Source Type: research

Anti-PD-1 immunotherapy in combination with sequential involved-site radiotherapy in heavily pretreated refractory Hodgkin lymphoma.
ice P Abstract The purpose of this study was to assess efficacy and tolerance of anti-programmed death (PD)-1 immunotherapy in combination with sequential involved-site radiotherapy in heavily pretreated refractory Hodgkin lymphoma. In this case series, we reported the outcome of four heavily pretreated patients with refractory Hodgkin lymphoma treated by anti-PD-1 immunotherapy and involved site radiation therapy. After a median follow-up of 13-month, all patients were alive with complete metabolic response. After radiotherapy, all four patients experienced lung toxicity, which was resolved after antibiotherapy w...
Source: Cancer Radiotherapie - February 4, 2019 Category: Cancer & Oncology Authors: Quéro L, Gilardin L, Fumagalli I, Martin V, Guillerm S, Bauduceau O, Kirova YM, Hennequin C, Brice P Tags: Cancer Radiother Source Type: research

Multidisciplinary treatment approach for primary thyroid spindle cell sarcoma: A case report.
Abstract A 25-year-old female with high-grade spindle cell sarcoma of the thyroid persistent after thyroidectomy performed at another hospital was referred to our institute. Chemotherapy followed by surgery with intraoperative radiotherapy and postoperative intensity-modulated radiotherapy were planned within the sarcoma board. Chemotherapy was discontinued after two cycles because of local disease progression and surgery with intraoperative radiotherapy, was anticipated. The treatment was completed with postoperative radiotherapy. After 36 months off-therapy, the patient was free of disease without significant la...
Source: Cancer Radiotherapie - January 11, 2019 Category: Cancer & Oncology Authors: Navarria F, Gigante M, Mascarin M, Italia F, Barresi L, Barzan L, Bertola G, Buonadonna A, Canzonieri V, De Paoli A Tags: Cancer Radiother Source Type: research

Harmonization of practices between radiotherapy centres in the Nord and Pas-de-Calais regions (France): A three-year evaluation.
CONCLUSION: This work makes it possible to harmonize the delineation practices around validated standards. An extension to the entire Hauts-de-France region is planned. PMID: 30639377 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 10, 2019 Category: Cancer & Oncology Authors: Pasquier D, Darloy F, Dewas S, Gras L, Maillard S, Rhliouch H, Tokarski M, Wagner JP, Degrendel-Courtecuisse AC, Dufour C, Fares M, Gilbeau L, Olszyk O, Castelain B, Lartigau É Tags: Cancer Radiother Source Type: research

Isomorphic and isotopic responses after radiation therapy.
PMID: 30639378 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 10, 2019 Category: Cancer & Oncology Authors: De Vita V, Ruocco E Tags: Cancer Radiother Source Type: research

[Chemoradiation for oesophageal cancer: A critical review of the literature].
Troussier I Abstract Locally advanced oesophageal cancer treatment requires a multidisciplinary approach with the combination of chemotherapy and radiotherapy for preoperative and definitive strategy. Preoperative chemoradiation improves the locoregional control and overall survival after surgery for locally advanced oesophageal cancer. Definitive chemoradiation can also be proposed for non-resectable tumours or medically inoperable patients. Besides, definitive chemoradiation is considered as an alternative option to surgery for locally advanced squamous cell carcinomas. Chemotherapy regimen associated to radioth...
Source: Cancer Radiotherapie - January 10, 2019 Category: Cancer & Oncology Authors: Blais E, Vendrely V, Sargos P, Créhange G, Huguet F, Maingon P, Simon JM, Bourdais R, Ozsahin M, Bourhis J, Clément-Colmou K, Belghith B, Proudhom Briois MA, Gilliot O, Dujols JP, Peyras A, Dupin C, Riet FG, Canova CH, Huertas A, Troussier I Tags: Cancer Radiother Source Type: research

[Locoregional control and patterns of locoregional failure in women with breast cancer treated by highly conformal electron beam irradiation].
CONCLUSION: In presented series, the local recurrence resulted mostly from of biologic radio resistance whereas regional recurrences were caused by geographical miss. A number of nodal recurrences could occur outside the target volumes defined by ESTRO and RTOG. PMID: 30595340 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 27, 2018 Category: Cancer & Oncology Authors: Loganadane G, Xi Z, Fournier-Bidoz N, Xu HP, Grellier Adedjouma N, Bazire L, Fourquet A, Kirova YM Tags: Cancer Radiother Source Type: research

[Thyroid function after hypofractionated adjuvant radiotherapy for localized breast cancer].
CONCLUSION: Although hypofractionation theoretically exposes the thyroid gland to late radiotherapy complications, radiation-induced dysthyroidism remains a complication underestimated by clinicians, and in the absence of prevention and treatment guidelines, it is necessary to delineate systematically the thyroid gland, to try to minimize as much as possible the doses received by this organ, and to monitor the thyroid function by periodic serum assays. PMID: 30595341 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 27, 2018 Category: Cancer & Oncology Authors: Dahbi Z, Sbai A, Mezouar L Tags: Cancer Radiother Source Type: research

[Contribution and limits of intensity-modulated reirradiation of nasopharyngeal carcinomas].
CONCLUSION: Intensity-modulation is an attractive technique for reirradiation of the nasopharynx. It allows a better conformity of the dose to the target and a reduction of the doses on the already irradiated critical organs. This offers good control of the disease with fewer severe late toxicities. PMID: 30563746 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 15, 2018 Category: Cancer & Oncology Authors: Farhat L, Mnejja W, Fourati N, Daoud H, Sahnoun T, Ben Kridis W, Ghorbel A, Frikha M, Siala W, Daoud J Tags: Cancer Radiother Source Type: research

[Quality and safety policy implementation for a new radiotherapy device].
Abstract Modern radiotherapy techniques (intensity-modulated radiotherapy, volumetric-modulated arctherapy, image-guided radiotherapy) or stereotactic radiotherapy are in expansion in most French cancer centres. The arrival of such techniques requires updates of existing equipment or implementation of new radiotherapy devices with adapted options. With the arrival of these new devices, there is a need to develop a quality and safety policy. This is necessary to ease the process from the setup to the first treated patient. The quality and safety policy is maintained to ensure the quality assurance of the radiothera...
Source: Cancer Radiotherapie - December 14, 2018 Category: Cancer & Oncology Authors: Martin C, Jumeau R, Blais E, Canova CH, Klausner G, Dumas R, Rouger A, Pariente F, Lyothier A, Slama Y, Dol J, Perret J, Jenny C, Chea M, Pasdeloup F, Maingon P, Troussier I Tags: Cancer Radiother Source Type: research

Radiation therapy after sentinel lymph node biopsy for early stage breast cancer using a magnetic tracer: Results of a single institutional prospective study of tolerance.
CONCLUSION: The results of this large-scale study show that the radiotherapy after sentinel lymph node biopsy using super paramagnetic iron oxide particles is feasible, and that no increase of the toxicity was observed. PMID: 30553652 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 12, 2018 Category: Cancer & Oncology Authors: Bazire L, Alran S, El Bamrani S, Gaujal L, Vincent-Salomon A, Tardivon A, Kirova YM Tags: Cancer Radiother Source Type: research