A new delineation method research of the clinical target volume for pancreatic cancer adjuvant radiotherapy.
CONCLUSIONS: A majority of postoperative local recurrences in patients with pancreatic head and body cancer are contained within a smaller region surrounding the celiac artery and superior mesenteric artery. The "new" volumes targeting high risk local failures may allow dose escalation and enhanced local control while minimizing radiation-related toxicity. PMID: 31101540 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 14, 2019 Category: Cancer & Oncology Authors: Zhang TT, Wei L, Yuan GW, Zhao DQ, Zhang ML, Zhang GF, Wang PC Tags: Cancer Radiother Source Type: research

[Delineation of the primary tumour clinical target volumes and neck node levels selection of parotid cancers].
This article presents a synthesis of patterns and paths of invasion of parotid glands tumours in order to propose an approach of the delineation of primary tumour clinical target volumes and of the selection of lymph nodes target volumes. This article does not discuss treatment indications but defines clinical target volumes to treat if radiotherapy is indicated. Postoperative situation being the most frequent, the delineation of primary tumour clinical target volume is based on an anatomical approach. PMID: 31101541 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 14, 2019 Category: Cancer & Oncology Authors: Piram L, Frédéric-Moreau T, Bellini R, Martin F, Miroir J, Saroul N, Pham Dang N, Biau J, Lapeyre M Tags: Cancer Radiother Source Type: research

Psychoaffective repercussions of pain in cancer patients.
CONCLUSION: The prevalence of anxiety and depression in our patients was slightly higher than those reported in the literature. The main factors correlated with the onset of depression and anxiety were: severe pain, bone location, and advanced stage of the disease. PMID: 31097369 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 13, 2019 Category: Cancer & Oncology Authors: Khemiri S, Ben Thabet J, Ben Kridis W, Maalej M, Khanfir A, Frikha M Tags: Cancer Radiother Source Type: research

(68Ga)-PSMA-PET/CT for the detection of postoperative prostate cancer recurrence: Possible implications on treatment volumes for radiation therapy.
CONCLUSION: Most of the patients in the present study, presented with distant lymph node and/or bone metastases. Therefore, larger target volumes should be adopted to treat at least 95% of lymph node regions at risk for an occult relapse. PMID: 31088725 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 11, 2019 Category: Cancer & Oncology Authors: De Bari B, Mazzola R, Aiello D, Aloi D, Gatta R, Corradini S, Salgarello M, Alongi F Tags: Cancer Radiother Source Type: research

[Physiopathology and pharmacological perspectives in the treatment of radiation enteritis].
ari C Abstract The small intestine is an organ frequently exposed in abdominal and pelvic irradiations. Acute and late toxicity can sometimes be difficult to manage and can significantly affect the quality of life of patients. Currently there is no guideline on the management of acute and late side effects induced by therapeutic irradiation. The aim of this review is to summarize available data on the pathophysiology of radiation enteritis, and to highlight potential preventive strategies and principles of treatment of radiation enteritis. PMID: 31060972 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 3, 2019 Category: Cancer & Oncology Authors: Rehailia-Blanchard A, He MY, Rancoule C, Vallard A, Espenel S, Nivet A, Magné N, Chargari C Tags: Cancer Radiother Source Type: research

Whole breast radiotherapy in the isocentric lateral decubitus position: Role of the immobilization device and table on clinical results.
CONCLUSIONS: Whole breast radiotherapy in the isocentric lateral decubitus position is well tolerated. Clinical results are comparable based on different immobilization device allowed by linear accelerators. Particularly, there was no influence of the couch on skin tolerance and cosmetic results. PMID: 31053514 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 30, 2019 Category: Cancer & Oncology Authors: Krhili S, Costa E, Xu HP, Kirova YM Tags: Cancer Radiother Source Type: research

Erratum to: "Multidisciplinary treatment approach for primary thyroid spindle cell sarcoma: A case report" [Cancer Radiother. 23 (2019) 46-9].
Erratum to: "Multidisciplinary treatment approach for primary thyroid spindle cell sarcoma: A case report" [Cancer Radiother. 23 (2019) 46-9]. Cancer Radiother. 2019 Apr 05;: Authors: Navarria F, Gigante M, Mascarin M, Italia F, Barresi L, Barzan L, Bertola G, Buonadonna A, Canzonieri V, De Paoli A PMID: 30962080 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 5, 2019 Category: Cancer & Oncology Authors: Navarria F, Gigante M, Mascarin M, Italia F, Barresi L, Barzan L, Bertola G, Buonadonna A, Canzonieri V, De Paoli A Tags: Cancer Radiother Source Type: research

[Left-sided breast cancer locoregional radiation therapy with rotational intensity-modulated irradiation and deep inspiration breath hold: Dosimetric comparison].
CONCLUSION: Rotational intensity-modulated radiotherapy with deep inspiration breath hold is associated with better sparing of the heart, on the right and left anterior descending coronary arteries, and on the aortic valve, compared with free breathing techniques, for adjuvant left breast cancer locoregional irradiation. PMID: 30954386 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 3, 2019 Category: Cancer & Oncology Authors: Fessart É, Crop F, Tresch E, Mirabel X, Lartigau É, Pasquier D Tags: Cancer Radiother Source Type: research

[Stereotactic body radiation therapy for hepatocellular carcinoma: Results from a retrospective multicentre study].
CONCLUSION: Stereotactic body radiation therapy is effective and well-tolerated for inoperable hepatocellular carcinoma or as a bridge to liver transplantation. Toxicity is mainly related to cirrhotic background and requires a selection of patients and strict dose constraints. PMID: 30952560 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 2, 2019 Category: Cancer & Oncology Authors: Scher N, Janoray G, Riet FG, Le Bayon AG, Debbi K, Lévy S, Louisot P, Garaud P, Chajon E, Barillot I, Salamé É, de Crevoisier R, Chapet S, Calais G Tags: Cancer Radiother Source Type: research

Chest wall pain following lung stereotactic body radiation therapy using 48Gy in three fractions: A search for predictors.
CONCLUSION: Our analysis could not find any correlation between the studied parameters and chest wall pain. Considering our present study and the wide range of differing results from the literature, a reasonable conclusion is that a constraint for chest wall pain is yet to be defined. PMID: 30952561 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 2, 2019 Category: Cancer & Oncology Authors: Albers J, Parker W, Kildea J, Pembroke C, Faria S Tags: Cancer Radiother Source Type: research

Patterns of locoregional failure in women with early-stage breast cancer treated by whole breast irradiation in the lateral isocentric decubitus position: Large-scale single-centre experience.
va YM Abstract PURPOSE: The purpose of this study was to evaluate locoregional control and describe the patterns of failure in patients with breast cancer receiving whole breast radiotherapy in the isocentric lateral decubitus position technique. PATIENTS AND METHODS: In a series of 832 consecutive female patients with early-stage breast cancer including invasive and in situ tumours treated by breast-conserving surgery followed by three-dimensional conformal whole breast irradiation in the isocentric lateral decubitus position between 2005 and 2010, all patients who experienced locoregional recurrence were st...
Source: Cancer Radiotherapie - March 29, 2019 Category: Cancer & Oncology Authors: Xu HP, Bronsart E, Costa É, Krhili S, Logerot C, Bazire L, Fournier-Bidoz N, Belshi A, Fourquet A, Kirova YM Tags: Cancer Radiother Source Type: research

Partial versus whole breast irradiation: Side effects, patient satisfaction and costs.
Abstract PURPOSE: Since accelerated partial breast irradiation has demonstrated non-inferiority to whole breast irradiation regarding recurrence rate in patients with early stage breast cancer, our objective was to compare its impact on short-term adverse events, patient satisfaction and costs. MATERIALS AND METHODS: Patients with early stage breast cancer treated by breast-conserving surgery between 2007 and 2012 were included: 48 women who received three-dimensional conformal accelerated partial breast irradiation in a multicentre phase-II trial were paired with 48 patients prospectively treated with whole ...
Source: Cancer Radiotherapie - March 28, 2019 Category: Cancer & Oncology Authors: Bathily T, Borget I, Rivin Del Campo E, Rivera S, Bourgier C Tags: Cancer Radiother Source Type: research

[Effects of high-dose irradiation on vascularization: Physiopathology and clinical consequences].
uet F Abstract A review of the literature has been conducted to better understand the effect of stereotactic radiotherapy on tumour vascularization and their consequences. High irradiation doses cause the death of endothelial cells by apoptosis through the ceramide pathway. Vascular consequences are multiple: increased permeability, decreased blood flow, increased hypoxia and tumoral necrosis. This necrosis causes an indirect death of the cancer cells in the days following the irradiation. The importance of indirect cell death in tumour control remains controversial, but it can explain the good clinical results of...
Source: Cancer Radiotherapie - March 25, 2019 Category: Cancer & Oncology Authors: Nivet A, Schlienger M, Clavère P, Huguet F Tags: Cancer Radiother Source Type: research

[Treatment of patients with brain metastases from a melanoma].
e;, Meyer N Abstract Whereas immune checkpoint inhibitors of serine/threonine protein kinase B-raf therapy dramatically changed metastatic outcomes of patients with melanoma, they remain at high risk of brain extension. Additional local treatment can be offered in this situation such as surgery and or stereotactic radiotherapy. In this review article, we describe the different options with published data and their optimal timing. PMID: 30904418 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 20, 2019 Category: Cancer & Oncology Authors: Modesto A, Chira C, Sol JC, Lubrano V, Boulinguez S, Pagès C, Sibaud V, Gomez-Roca C, Moyal É, Meyer N Tags: Cancer Radiother Source Type: research

[Medical prevention and treatment of radiation-induced urological and nephrological complications].
né N Abstract Abdominal and pelvic irradiations play a major place in the management of patients with cancer and present a risk of acute and late side effects. Radiation-induced lesions can affect kidney or urological structures. These side effects can have an impact in the quality of life of patients. The aim of this article is to describe the physiopathology, the symptomatology, and the principles of management of radiation-induced nephropathy, uretheritis, cystitis, and urethritis. PMID: 30898418 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 18, 2019 Category: Cancer & Oncology Authors: Rehailia-Blanchard A, He MY, Rancoule C, Guillaume É, Guy JB, Vial N, Nivet A, Orliac H, Chargari C, Magné N Tags: Cancer Radiother Source Type: research

Construction and clinical evaluation of a new customized bite block used in radiotherapy of head and neck cancer.
CONCLUSION: A customized bite block is easy-made and worthy of clinical use. PMID: 30898419 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 18, 2019 Category: Cancer & Oncology Authors: Feng Z, Wang P, Gong L, Xu L, Zhang J, Zheng J, Zhang D, Tian T, Wang P Tags: Cancer Radiother Source Type: research

Dose fall-off patterns with volumetric modulated arc therapy and three-dimensional conformal radiotherapy including the "organ at risk" effect. Experience of linear accelerator-based frameless radiosurgery from a single institution.
CONCLUSION: Our study presents the dose fall-off patterns in context of frameless stereotactic radiation therapy. We have presented the dose fall-off data in the framework of three-dimensional conformal radiotherapy and volumetric modulated arc therapy in brain lesions. PMID: 30797691 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - February 20, 2019 Category: Cancer & Oncology Authors: Munshi A, Sarkar B, Roy S, Ganesh T, Mohanti BK Tags: Cancer Radiother Source Type: research

Anti-PD-1 immunotherapy in combination with sequential involved-site radiotherapy in heavily pretreated refractory Hodgkin lymphoma.
ice P Abstract The purpose of this study was to assess efficacy and tolerance of anti-programmed death (PD)-1 immunotherapy in combination with sequential involved-site radiotherapy in heavily pretreated refractory Hodgkin lymphoma. In this case series, we reported the outcome of four heavily pretreated patients with refractory Hodgkin lymphoma treated by anti-PD-1 immunotherapy and involved site radiation therapy. After a median follow-up of 13-month, all patients were alive with complete metabolic response. After radiotherapy, all four patients experienced lung toxicity, which was resolved after antibiotherapy w...
Source: Cancer Radiotherapie - February 4, 2019 Category: Cancer & Oncology Authors: Quéro L, Gilardin L, Fumagalli I, Martin V, Guillerm S, Bauduceau O, Kirova YM, Hennequin C, Brice P Tags: Cancer Radiother Source Type: research

Multidisciplinary treatment approach for primary thyroid spindle cell sarcoma: A case report.
Abstract A 25-year-old female with high-grade spindle cell sarcoma of the thyroid persistent after thyroidectomy performed at another hospital was referred to our institute. Chemotherapy followed by surgery with intraoperative radiotherapy and postoperative intensity-modulated radiotherapy were planned within the sarcoma board. Chemotherapy was discontinued after two cycles because of local disease progression and surgery with intraoperative radiotherapy, was anticipated. The treatment was completed with postoperative radiotherapy. After 36 months off-therapy, the patient was free of disease without significant la...
Source: Cancer Radiotherapie - January 11, 2019 Category: Cancer & Oncology Authors: Navarria F, Gigante M, Mascarin M, Italia F, Barresi L, Barzan L, Bertola G, Buonadonna A, Canzonieri V, De Paoli A Tags: Cancer Radiother Source Type: research

Harmonization of practices between radiotherapy centres in the Nord and Pas-de-Calais regions (France): A three-year evaluation.
CONCLUSION: This work makes it possible to harmonize the delineation practices around validated standards. An extension to the entire Hauts-de-France region is planned. PMID: 30639377 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 10, 2019 Category: Cancer & Oncology Authors: Pasquier D, Darloy F, Dewas S, Gras L, Maillard S, Rhliouch H, Tokarski M, Wagner JP, Degrendel-Courtecuisse AC, Dufour C, Fares M, Gilbeau L, Olszyk O, Castelain B, Lartigau É Tags: Cancer Radiother Source Type: research

Isomorphic and isotopic responses after radiation therapy.
PMID: 30639378 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 10, 2019 Category: Cancer & Oncology Authors: De Vita V, Ruocco E Tags: Cancer Radiother Source Type: research

[Chemoradiation for oesophageal cancer: A critical review of the literature].
Troussier I Abstract Locally advanced oesophageal cancer treatment requires a multidisciplinary approach with the combination of chemotherapy and radiotherapy for preoperative and definitive strategy. Preoperative chemoradiation improves the locoregional control and overall survival after surgery for locally advanced oesophageal cancer. Definitive chemoradiation can also be proposed for non-resectable tumours or medically inoperable patients. Besides, definitive chemoradiation is considered as an alternative option to surgery for locally advanced squamous cell carcinomas. Chemotherapy regimen associated to radioth...
Source: Cancer Radiotherapie - January 10, 2019 Category: Cancer & Oncology Authors: Blais E, Vendrely V, Sargos P, Créhange G, Huguet F, Maingon P, Simon JM, Bourdais R, Ozsahin M, Bourhis J, Clément-Colmou K, Belghith B, Proudhom Briois MA, Gilliot O, Dujols JP, Peyras A, Dupin C, Riet FG, Canova CH, Huertas A, Troussier I Tags: Cancer Radiother Source Type: research

[Locoregional control and patterns of locoregional failure in women with breast cancer treated by highly conformal electron beam irradiation].
CONCLUSION: In presented series, the local recurrence resulted mostly from of biologic radio resistance whereas regional recurrences were caused by geographical miss. A number of nodal recurrences could occur outside the target volumes defined by ESTRO and RTOG. PMID: 30595340 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 27, 2018 Category: Cancer & Oncology Authors: Loganadane G, Xi Z, Fournier-Bidoz N, Xu HP, Grellier Adedjouma N, Bazire L, Fourquet A, Kirova YM Tags: Cancer Radiother Source Type: research

[Thyroid function after hypofractionated adjuvant radiotherapy for localized breast cancer].
CONCLUSION: Although hypofractionation theoretically exposes the thyroid gland to late radiotherapy complications, radiation-induced dysthyroidism remains a complication underestimated by clinicians, and in the absence of prevention and treatment guidelines, it is necessary to delineate systematically the thyroid gland, to try to minimize as much as possible the doses received by this organ, and to monitor the thyroid function by periodic serum assays. PMID: 30595341 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 27, 2018 Category: Cancer & Oncology Authors: Dahbi Z, Sbai A, Mezouar L Tags: Cancer Radiother Source Type: research

[Contribution and limits of intensity-modulated reirradiation of nasopharyngeal carcinomas].
CONCLUSION: Intensity-modulation is an attractive technique for reirradiation of the nasopharynx. It allows a better conformity of the dose to the target and a reduction of the doses on the already irradiated critical organs. This offers good control of the disease with fewer severe late toxicities. PMID: 30563746 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 15, 2018 Category: Cancer & Oncology Authors: Farhat L, Mnejja W, Fourati N, Daoud H, Sahnoun T, Ben Kridis W, Ghorbel A, Frikha M, Siala W, Daoud J Tags: Cancer Radiother Source Type: research

[Quality and safety policy implementation for a new radiotherapy device].
Abstract Modern radiotherapy techniques (intensity-modulated radiotherapy, volumetric-modulated arctherapy, image-guided radiotherapy) or stereotactic radiotherapy are in expansion in most French cancer centres. The arrival of such techniques requires updates of existing equipment or implementation of new radiotherapy devices with adapted options. With the arrival of these new devices, there is a need to develop a quality and safety policy. This is necessary to ease the process from the setup to the first treated patient. The quality and safety policy is maintained to ensure the quality assurance of the radiothera...
Source: Cancer Radiotherapie - December 14, 2018 Category: Cancer & Oncology Authors: Martin C, Jumeau R, Blais E, Canova CH, Klausner G, Dumas R, Rouger A, Pariente F, Lyothier A, Slama Y, Dol J, Perret J, Jenny C, Chea M, Pasdeloup F, Maingon P, Troussier I Tags: Cancer Radiother Source Type: research

Radiation therapy after sentinel lymph node biopsy for early stage breast cancer using a magnetic tracer: Results of a single institutional prospective study of tolerance.
CONCLUSION: The results of this large-scale study show that the radiotherapy after sentinel lymph node biopsy using super paramagnetic iron oxide particles is feasible, and that no increase of the toxicity was observed. PMID: 30553652 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 12, 2018 Category: Cancer & Oncology Authors: Bazire L, Alran S, El Bamrani S, Gaujal L, Vincent-Salomon A, Tardivon A, Kirova YM Tags: Cancer Radiother Source Type: research

[Which photon energy for intensity-modulated radiotherapy and volumetric-modulated arctherapy in 2019?]
uml;l A Abstract For more than a decade, the majority of radiation oncology centres have been delivering intensity-modulated radiotherapy (then volumetric-modulated arctherapy) with 6 MV photons as their standard of care. This « dogma » had been supported by the usual absence of dosimetric advantages with high-energy photons (15 to 18 MV or more), at least for the planning target volume and the dose received by the adjacent organs at risk, and by the neutron component as soon as the photon energy exceeds 10 MV. Recent data could question such a dogma. First, in 2019, one cannot avoid taking i...
Source: Cancer Radiotherapie - December 11, 2018 Category: Cancer & Oncology Authors: Cosset JM, Nassef M, Saïdi R, Pugnaire J, Ben Abdennebi A, Noël A Tags: Cancer Radiother Source Type: research

[Cost of radiotherapy for bone metastases in France: A monocentric retrospective study].
A, Noël G Abstract PURPOSE: The cost of radiotherapy is a concern for health systems. The conventional non fractionated or multifractionated schemes have shown the same efficacy in terms of pain relief but a non fractionated treatment seems less expensive. However, in general practice, multifractionated treatments are still the majority, which represents an additional cost for society. Moreover, the use of stereotactic body radiotherapy becomes more democratic and offers new curative perspectives, but at what price? MATERIAL AND METHODS: A monocentric retrospective study was conducted in a French radiot...
Source: Cancer Radiotherapie - December 4, 2018 Category: Cancer & Oncology Authors: Le Fèvre C, Menoux I, Pin Y, Antoni D, Thiéry A, Noël G Tags: Cancer Radiother Source Type: research

Rare histologic types of rectal cancer: A monocentric cases series report.
CONCLUSION: The present study highlights the rarity and the specificities of uncommon histologic types of rectal cancer. We report the real-life management and outcome of rare histologic types of rectal cancers, with dismal prognosis of stage IV tumours. We also report that treatments were adapted to histology. PMID: 30509567 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - November 30, 2018 Category: Cancer & Oncology Authors: Vallard A, Diao P, Garcia MA, Pigné G, Vial N, Forest F, Peoc'h M, Langrand-Escure J, Magné N Tags: Cancer Radiother Source Type: research

Clinical assessment of palliative radiotherapy for pancreatic cancer.
CONCLUSIONS: Following treatment, pain and clinical symptoms were improved in a considerable proportion of patients with pancreatic cancer, proving that palliative radiotherapy is feasible for pancreatic cancer. PMID: 30401617 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - November 3, 2018 Category: Cancer & Oncology Authors: Tian Q, Zhang F, Wang Y Tags: Cancer Radiother Source Type: research

[Siriade 2.0: An e-learning platform for radiation oncology contouring].
CONCLUSION: Siriade 2.0 is an innovating digital tool for radiation oncology initial and continuous education. PMID: 30360973 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 22, 2018 Category: Cancer & Oncology Authors: Bibault JE, Denis F, Roué A, Gibon D, Fumagalli I, Hennequin C, Barillot I, Quéro L, Paumier A, Mahé MA, Servagi Vernat S, Créhange G, Lapeyre M, Blanchard P, Pointreau Y, Lafond C, Huguet F, Mornex F, Latorzeff I, de Crevoisier R, Martin V, Kreps S, Tags: Cancer Radiother Source Type: research

Outcomes and treatments of IB1 cervical cancers with high recurrence risk: A 13 years' experience.
CONCLUSION: In current clinical practice, tailored treatments are delivered, and seems to give correct therapeutic index. However, clinical trials are needed to standardise treatment according to patient characteristics and recurrence risk factors. PMID: 30348607 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 19, 2018 Category: Cancer & Oncology Authors: Espenel S, Garcia MA, Vallard A, Langrand-Escure J, Guy JB, Trone JC, Ben Mrad M, Chauleur C, de Laroche G, Moreno-Acosta P, Rancoule C, Magné N Tags: Cancer Radiother Source Type: research

Prevalence of burnout, depression and job satisfaction among French senior and resident radiation oncologists.
eau S Abstract PURPOSE: Cancer caregivers are at high risk of burn-out, with potential severe consequences on professionals' health and on patients' care. We have investigated the prevalence of burn-out and its impact in terms of psychological morbidity among French radiation oncologists. METHODS AND MATERIALS: An anonymous online questionnaire was advertised in all French senior radiation oncologists and residents, including demographical data, job-related stress factors, drug use, the Maslach Burn-out Inventory (MBI) and the General Health Questionnaire (GHQ-12). RESULTS: The response rates were 37% (7...
Source: Cancer Radiotherapie - October 19, 2018 Category: Cancer & Oncology Authors: Lazarescu I, Dubray B, Joulakian MB, Blanchard P, Chauvet B, Mahé MA, Mornex F, Rocher F, Thureau S Tags: Cancer Radiother Source Type: research

[Results of a retrospective study on radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma].
CONCLUSION: Eradication of Helicobacter pylori is the mainstay of treatment of gastric MALT. External irradiation is an effective and well-tolerated treatment modality in case of resistance to helicobacter eradication. PMID: 30337049 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 15, 2018 Category: Cancer & Oncology Authors: Ghorbal L, Hdiji A, Ben Salah H, Elloumi F, Frikha M, Elloumi M, Daoud J Tags: Cancer Radiother Source Type: research

[Radiation-induced lung toxicity predictors after stereotactic radiation therapy for non-small cell lung carcinoma stage I].
This article is a literature review of this complication's predictive factors. PMID: 30337050 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 15, 2018 Category: Cancer & Oncology Authors: Menoux I, Le Fèvre C, Noël G, Antoni D Tags: Cancer Radiother Source Type: research

Concepts and terms for dose/volume parameters in carbon-ion radiotherapy: Conclusions of the ULICE taskforce.
Conclusions of the ULICE taskforce. Cancer Radiother. 2018 Oct 13;: Authors: Vogin G, Wambersie A, Pötter R, Beuve M, Combs SE, Magrin G, Mayer R, Mock U, Sarrut D, Schreiner T, Fossati P, Balosso J Abstract PURPOSE: The Union of Light Ion Centers in Europe (ULICE) program addressed the need for uniting scientific results for carbon-ion radiation therapy obtained by several institutions worldwide in different fields of excellence, and translating them into a real benefit to the community. Particularly, the concepts for dose/volume parameters developed in photon radiotherapy cannot be extrapolated...
Source: Cancer Radiotherapie - October 13, 2018 Category: Cancer & Oncology Authors: Vogin G, Wambersie A, Pötter R, Beuve M, Combs SE, Magrin G, Mayer R, Mock U, Sarrut D, Schreiner T, Fossati P, Balosso J Tags: Cancer Radiother Source Type: research

Dosimetric analysis of stereotactic rotational versus static intensity-modulated radiation therapy for pancreatic cancer.
Abstract PURPOSE: Stereotactic body radiation therapy is a promising treatment modality for locally advanced pancreatic cancer. To determine the optimal radiation treatment, we compared the plan characteristics of volumetric-modulated arc therapy and intensity-modulated radiation therapy when administered with stereotactic body radiation therapy to treat pancreatic cancer. PATIENTS AND METHODS: Fifteen patients with locally advanced pancreatic cancer were treated by stereotactic body radiation therapy at a dose of 24-32Gy in four fractions with marker-guided gated volumetric-modulated arc therapy. Four dimens...
Source: Cancer Radiotherapie - October 12, 2018 Category: Cancer & Oncology Authors: Cho I, Park JW, Cho B, Kwak J, Yoon SM, Nesseler JP, Park J, Kim JH Tags: Cancer Radiother Source Type: research

Contouring workload in adjuvant breast cancer radiotherapy.
Abstract PURPOSE: To measure the impact of contouring on worktime in the adjuvant radiation treatment of breast cancer, and to identify factors that might affect the measurements. MATERIAL AND METHODS: The dates and times of contouring clinical target volumes and organs at risk were recorded by a senior and by two junior radiation oncologists. Outcome measurements were contour times and the time from start to approval. The factors evaluated were patient age, type of surgery, radiation targets and setup, operator, planning station, part of the day and day of the week on which the contouring started. The Welch ...
Source: Cancer Radiotherapie - October 12, 2018 Category: Cancer & Oncology Authors: Andrianarison VA, Laouiti M, Fargier-Bochaton O, Dipasquale G, Wang X, Nguyen NP, Miralbell R, Vinh-Hung V Tags: Cancer Radiother Source Type: research

[Multidisciplinary consultation for patients with HPV-related invasive carcinoma or precancerous lesions].
This study fits more broadly in a theme of clinical and fundamental research around cancers related to HPV. PMID: 30197024 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 6, 2018 Category: Cancer & Oncology Authors: Badoual C, Pavie J, Ménard M, Pernot S, Cochand-Priollet B, Hurel S, Péré H, Bats AS Tags: Cancer Radiother Source Type: research

[Hypofractioned radiotherapy in elderly patient with glioblastoma].
Abstract Glioblastoma is the most frequent primary brain tumor, with more than half of all patients being at least 65 years old. The treatment of the elderly in this pathology represents therefore a considerable challenge for oncologists and radiation therapists. However, in most clinical trials, age is a non-eligible criterial. In the last ten years, geriatric therapeutic trials have been multiplied. The treatment of glioblastoma consists of adjuvant chemoradiotherapy. In elderly patients, the evaluation of performans status and the molecular characteristics of the tumor are important factors in order to propose ...
Source: Cancer Radiotherapie - September 6, 2018 Category: Cancer & Oncology Authors: Kuntz L, Noel G, Antoni D Tags: Cancer Radiother Source Type: research

Combining radiation therapy and cancer immune therapies: From preclinical findings to clinical applications.
Abstract Besides its direct cytotoxic effect on the tumor cells, radiation therapy is also able to elicit an immune-mediated systemic anti-tumor response, resulting in tumor regression in irradiated sites but also within distant out of field secondary lesions and providing a long-term anti-tumor response. It is now clear that associating ionizing radiation with immune therapies can enhance radio-induced anti-tumor immune responses. Over the last decade, such a combination aroused considerable interest among the scientific community, with many preclinical models and clinical trials, using many types of immune thera...
Source: Cancer Radiotherapie - September 6, 2018 Category: Cancer & Oncology Authors: Bockel S, Durand B, Deutsch E Tags: Cancer Radiother Source Type: research

[Prevalence and expectations of "alternative and complementary medicine" use during radiotherapy in 2016: A prospective study].
[Prevalence and expectations of "alternative and complementary medicine" use during radiotherapy in 2016: A prospective study]. Cancer Radiother. 2018 Sep 06;: Authors: Dupin C, Arsène-Henry A, Charleux T, Haaser T, Trouette R, Vendrely V Abstract PURPOSE: Alternative and complementary medicine is defined as any substance or technique of non-allopathic medicine used to improve health and quality of life. The purpose of this prospective observational study was to evaluate the use of alternative and complementary medicine during radiotherapy. MATERIAL AND METHODS: A questionnaire w...
Source: Cancer Radiotherapie - September 6, 2018 Category: Cancer & Oncology Authors: Dupin C, Arsène-Henry A, Charleux T, Haaser T, Trouette R, Vendrely V Tags: Cancer Radiother Source Type: research

[Chemotherapy and chemoradiotherapy indications in the treatment of locally advanced gastric carcinoma].
aud R Abstract Currently, there is no international consensus on the best treatment regimen for patients with advanced resectable gastric carcinoma. Three approaches exist abroad continents. In France and Europe, perioperative chemotherapy and gastrectomy with D1.5 lymph-node dissection is the current standard. In Japan and South Korea, postoperative adjuvant chemotherapy after surgery with D2 lymph-node dissection is the standard treatment. In the United States, where limited lymph-node dissection is frequently performed, adjuvant chemoradiotherapy after surgery is the standard treatment. In France, postoperative...
Source: Cancer Radiotherapie - September 5, 2018 Category: Cancer & Oncology Authors: Quéro L, Guimbaud R Tags: Cancer Radiother Source Type: research

[Implementation of experience feedback committees meetings between the radiotherapy centres of Northern France by the regional oncology network].
This article details how such experiential feedback committees are implemented, what they can contribute and the barriers to such work at each stage of the project. PMID: 30195981 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 5, 2018 Category: Cancer & Oncology Authors: Viot C, Crombet S, Tokarski M Tags: Cancer Radiother Source Type: research

[Reference bases of radiotherapy under stereotaxic conditions for bronchopulmonary, hepatic, prostatic, upper aero-digestive, cerebral and bone tumors or metastases].
Abstract Since decades, stereotactic radiotherapy has spread out worldwide. Published results are very numerous. To clarify obviousness among all the publications, this recommendation review was written. Voluntarily, authors limited analysis of international best evidence literature on malignant tumors of lung, liver, prostate, head and neck, and metastasis of bone and brain. These data could be used to advance standardization and quality improvement of treatments performed in the nationwide radiotherapy departments and can provide useful guidance for centers worldwide. PMID: 30195982 [PubMed - as supplied by...
Source: Cancer Radiotherapie - September 5, 2018 Category: Cancer & Oncology Authors: Barillot I, Antoni D, Bellec J, Biau J, Giraud P, Jenny C, Lacornerie T, Lisbona A, Marchesi V, Mornex F, Supiot S, Thureau S, Noel G Tags: Cancer Radiother Source Type: research

[Anal canal cancer: In the era of intensity-modulated radiotherapy, outstanding issues].
Abstract Intensity-modulated radiotherapy makes possible to optimize the irradiation and spare normal tissues. The toxicity remains important with concomitant chemotherapy often associated. The improvement of MRI and PET-CT define more precisely the target volumes, which need a higher dose, but necessitates to respect the rules of contouring. The treatment is uniform whatever the stage but should be individualized based on clinical stage and tumor response. New paradigms concern biology, staging, volumes and doses, fractionation and combined treatments. PMID: 30181029 [PubMed - as supplied by publisher] (Sour...
Source: Cancer Radiotherapie - September 1, 2018 Category: Cancer & Oncology Authors: Peiffert D, Baumann AS, Serre AA, Vendrely V, Rouard N, Faivre JC, Vogin G Tags: Cancer Radiother Source Type: research

[Organization and risk management in stereotaxic body radiotherapy at the treatment station].
Abstract The development of stereotaxic body radiotherapy in the last decade has forced the radiotherapy departments to redouble their efforts in the fields of quality and risk management. For this purpose, increasingly complex and rigorous controls of high performance machines as well as a solid team training must be put in place. Extreme hypofractionation requires both increased vigilance at the treatment desk and well-defined and known procedures. The in place organizations contribute to the control of the risks related to the stereotaxic body radiotherapy machines. The medical presence at the beginning of the ...
Source: Cancer Radiotherapie - September 1, 2018 Category: Cancer & Oncology Authors: Bouvet C, Bertin K, Lafond C, Willaume D, de Crevoisier R, Leroy E Tags: Cancer Radiother Source Type: research

[Surgery after upfront radiochemotherapy for locally advanced esophageal cancer: To do or not to do?]
iac M Abstract The treatment of locally advanced esophageal cancer is still evolving. Surgery was considered as the backbone of the therapeutic management for a long time. Nowadays, chemoradiation has taken a major place in the neoadjuvant setting or as an exclusive treatment. Although some patients benefit from esophagectomy after chemoradiotherapy, a large subset of patients has no benefit and morbi-mortality rates are increased with a trimodality strategy. Patients who will have a local failure are at high risk of distant metastases in the follow-up. A third group of patients will have persistent locoregional d...
Source: Cancer Radiotherapie - August 30, 2018 Category: Cancer & Oncology Authors: Créhange G, Mabrut JY, Rouffiac M Tags: Cancer Radiother Source Type: research

[Rectal cancer radiotherapy: Therapeutical strategy and perspective].
Abstract Standard treatment consisting of chemoradiotherapy followed by radical surgery with total mesorectal excision, resulting in good oncologic local control but high morbidity and poor functional results. The same treatment applied to all patients presenting with low or mid T3-4 rectal tumors could result in overtreatment of small tumors. However, it remains insufficient (or unsatisfactory?) for locally advanced tumors regarding metastatic recurrence rate. Treatment is decided by a multidisciplinary board on the basis of initial staging, including MRI which allows for resection margin prediction and post...
Source: Cancer Radiotherapie - August 28, 2018 Category: Cancer & Oncology Authors: Vendrely V, Denost Q, Charleux T, Brouquet A, Huguet F, Rullier E Tags: Cancer Radiother Source Type: research