[Brachytherapy in France in 2020: State of the art and perspectives from the Groupe curieth érapie de la SFRO].
[Brachytherapy in France in 2020: State of the art and perspectives from the Groupe curiethérapie de la SFRO]. Cancer Radiother. 2020 Jun 20;: Authors: Hannoun-Lévi JM, Chand MÈ, Blanchard P, Chargari C, Escande A, Pierrat N, Pommier P, Peiffert D Abstract Because of its principle and its high proof level clinical results, brachytherapy represents a specific irradiation technique for the treatment of primary tumors as well as some local relapses in pre-irradiated area. After a glory period between the 80's and 90's, brachytherapy has progressively lost its attractiveness. In order...
Source: Cancer Radiotherapie - June 20, 2020 Category: Cancer & Oncology Authors: Hannoun-Lévi JM, Chand MÈ, Blanchard P, Chargari C, Escande A, Pierrat N, Pommier P, Peiffert D Tags: Cancer Radiother Source Type: research

Hyaluronic acid spacer in focal prostate reirradiation: A single centre experience.
CONCLUSION: Reirradiation after local recurrence following initial definitive radiotherapy together with hyaluronic acid spacer use seems to be effective and safe. PMID: 32565071 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 18, 2020 Category: Cancer & Oncology Authors: Ozyigit G, Hurmuz P, Akinci D, Esen SCB, Yilmaz MT, Akdogan B, Akyol FH Tags: Cancer Radiother Source Type: research

Radiological assessment after stereotactic body radiation of lung tumours.
Abstract The increasing use of stereotactic body radiation therapy for lung tumours comes along with new post-therapeutic imaging findings that should be known by physicians involved in patient follow-up. Radiation-induced lung injury is much more frequent than after conventional radiation therapy, it can also be delayed and has a different radiological presentation. Radiation-induced lung injury after stereotactic body radiation therapy involves the lung parenchyma surrounding the target tumour and appears as a dynamic process continuing for years after completion of the treatment. Thus, the radiological pattern ...
Source: Cancer Radiotherapie - June 10, 2020 Category: Cancer & Oncology Authors: Chassagnon G, Martini K, Giraud P, Revel MP Tags: Cancer Radiother Source Type: research

Diagnostic performance of imaging techniques for detecting of local recurrence after prostate brachytherapy.
CONCLUSION: Both MRI and fluorocholine PET/CT permit to highlight local recurrence sites after prostate brachytherapy. Confirmation biopsies are, however, necessary since this accuracy is insufficient. PMID: 32532578 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 9, 2020 Category: Cancer & Oncology Authors: Karahissarlian V, Sargos P, Blais E, Cazeau AL, Fontes F, Petitpierre F, Rigou G, De Vaugelade C, Mariey A, Hindié E, Thomas L Tags: Cancer Radiother Source Type: research

Interventional radiology for treatment of bone metastases.
Abstract Therapeutic advances in oncology have led to longer survival in many forms of cancer, including those complicated by bone metastases. When a bone metastasis is painful or when there is a risk of fracture, interventional radiology procedures can be carried out for pain control and/or stabilisation. All of these techniques can be performed under local anaesthesia. Cementoplasty and vertebroplasty are stabilisation procedures consisting in the percutaneous injection of acrylic cement into a lytic bone lesion. The effect on pain can be explained by the consolidation of weakened, fractured or pre-fractured bon...
Source: Cancer Radiotherapie - June 8, 2020 Category: Cancer & Oncology Authors: Hayek G, Kastler B Tags: Cancer Radiother Source Type: research

Multimodal imaging in radiotherapy: Focus on adaptive therapy and quality control.
Abstract Improved computer resources in radiation oncology department have greatly facilitated the integration of multimodal imaging into the workflow of radiation therapy. Nowadays, physicians have highly informative imaging modalities of the anatomical region to be treated. These images contribute to the targeting accuracy with the current treatment device, impacting both segmentation or patient's positioning. Additionally, in a constant effort to deliver personalized care, many teams seek to confirm the benefits of adaptive radiotherapy. The published works highlight the importance of registration algorithms, p...
Source: Cancer Radiotherapie - June 6, 2020 Category: Cancer & Oncology Authors: Talbot A, Devos L, Dubus F, Vermandel M Tags: Cancer Radiother Source Type: research

Methods to delineate tumour for radiotherapy by fluorodeoxyglucose positron emission tomography.
Abstract Numerous articles have been published showing the interest to delineate tumours using fluorodeoxyglucose positron emission tomography/computed tomography images in radiotherapy planning. This imaging is used to identify tumour tissues with increased glucose metabolism compared to healthy surrounding tissues. This volume corresponds to the metabolic tumour volume. Despite extensive research on metabolic tumour volume segmentation methods, there is currently no consensus on the optimal segmentation method to use. In this review, the main methods proposed in the literature are presented, as well as their adv...
Source: Cancer Radiotherapie - June 4, 2020 Category: Cancer & Oncology Authors: Gardin I Tags: Cancer Radiother Source Type: research

[Research ethics: French regulations and applications in radiation oncology].
This article aims to summarise French regulations. Selected examples are specifically taken into the field of radiation oncology research. PMID: 32499188 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 1, 2020 Category: Cancer & Oncology Authors: Haaser T, Berdaï D, Trouette R, Dupin C, Marty S, L'Azou B, Berger V, Saux MC Tags: Cancer Radiother Source Type: research

Collision prediction for intracranial stereotactic radiosurgery planning: An easy-to-implement analytical solution.
CONCLUSION: This tool accurately predicted collisions for linac-based intracranial SRS and is easy to implement in any radiotherapy facility. PMID: 32467083 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 25, 2020 Category: Cancer & Oncology Authors: Felefly T, Achkar S, Khater N, Sayah R, Fares G, Farah N, El Barouky J, Azoury F, El Khoury C, Roukoz C, Nehme Nasr D, Nasr E Tags: Cancer Radiother Source Type: research

Benefits of positron emission tomography scans for the evaluation of radiotherapy.
The objective of this article is to review published data on positron emission tomography combined with computed tomography as a tool for evaluating external radiotherapy for cancers. Data on positron emission tomography combined with computed tomography scans acquired at different times (during, after initial and after definitive [chemo-]radiotherapy, during post-treatment follow-up) in solid tumours (lung, head and neck, cervix, oesophagus, prostate and rectum) were collected and analysed. Recent recommendations of the National Comprehensive Cancer Network are also reported. Positron emission tomography combined with com...
Source: Cancer Radiotherapie - May 21, 2020 Category: Cancer & Oncology Authors: Decazes P, Thureau S, Modzelewski R, Damilleville-Martin M, Bohn P, Vera P Tags: Cancer Radiother Source Type: research

Ultra-high dose-rate (FLASH) radiotherapy: Generation of early, transient, strongly acidic spikes in the irradiated tumor environment.
Abstract Monte Carlo simulations of γ/fast electron-radiolysis of water show that the in situ formation of H3O+ temporarily renders each "native" isolated spur/track region very acidic. For pulsed (FLASH) irradiation with high dose rate, this early time, transient "acid-spike" response is shown to extend evenly across the entire irradiated volume. Since pH controls many cellular processes, this study highlights the need to consider these spikes of acidity in understanding the fundamental mechanisms underlying FLASH radiotherapy. PMID: 32446537 [PubMed - as supplied by publisher] (Sou...
Source: Cancer Radiotherapie - May 20, 2020 Category: Cancer & Oncology Authors: Jay-Gerin JP Tags: Cancer Radiother Source Type: research

Hodkgin lymphoma concomitant of tuberculosis, a therapeutic challenge for multidisciplinary management.
We report the case of a 28-year-old patient concomitantly diagnosed of a Hodgkin lymphoma and active tuberculosis. Initial staging was difficult due to pulmonary and abdominal tuberculosis localization that induced FDG PET/CT hypermetabolism. Anti-tuberculosis treatment was first started, allowing secondary an early accurate Hodgkin lymphoma staging by FDG PET/CT. The patient was then treated by chemotherapy and radiotherapy. Helical TomoTherapy® was used with involved site (IS) irradiation volume was performed to decrease the high doses to organs-at-risk (OAR), especially lungs in this context of tuberculosis. PM...
Source: Cancer Radiotherapie - May 19, 2020 Category: Cancer & Oncology Authors: Boilève A, Kuhnowski F, Cassou-Mounat T, Jehanno N, Kirova Y Tags: Cancer Radiother Source Type: research

[MRI can be prescribed in patients with implanted cardiac devices (pacemaker, defibrillator) to optimize radiotherapy planning].
CONCLUSIONS: MRI may be performed in ICD patients, as the risk of morbidity is very low; provided that tridisciplinary evaluation is performed. PMID: 32444285 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 19, 2020 Category: Cancer & Oncology Authors: Bouter J, Lacroix J, Baud J, Thariat J Tags: Cancer Radiother Source Type: research

Outcomes of concurrent radiotherapy with weekly docetaxel and platinum-based chemotherapy in stage III non-small-cell lung cancer.
CONCLUSIONS: Weekly docetaxel and platinum-based drug doublet combined with TR yielded promising results in stage III NSCLC, with high survival rates. The toxicity of this association is acceptable, with mainly manageable esophagitis. These findings warrant validation in a prospective study before considering this association for standard of care. PMID: 32439358 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 18, 2020 Category: Cancer & Oncology Authors: Kaderbhaï CG, Coudert B, Bertaut A, Adnet J, Favier L, Lagrange A, Peignaux-Casasnovas K, Mettey L, Tharin Z, Foucher P, Martin E Tags: Cancer Radiother Source Type: research

[Practical guidelines for the radiotherapy for patients presented with haematological malignancies in the epidemic COVID-19 situation: International Lymphoma Radiation Oncology Group recommendations].
PMID: 32402596 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 4, 2020 Category: Cancer & Oncology Authors: Kirova Y Tags: Cancer Radiother Source Type: research

[Breast radiation therapy during COVID-19 outbreak: Practical advice].
uet A PMID: 32389580 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 4, 2020 Category: Cancer & Oncology Authors: Loap P, Kirova Y, Takanen S, Créhange G, Fourquet A Tags: Cancer Radiother Source Type: research

[Low dose lung radiotherapy for COVID-19-related cytokine storm syndrome: Why not?]
ari C PMID: 32389579 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 1, 2020 Category: Cancer & Oncology Authors: Cosset JM, Deutsch É, Bazire L, Mazeron JJ, Chargari C Tags: Cancer Radiother Source Type: research

Diffusion MRI: Technical principles and application to uterine cervical cancer.
Abstract Imaging is involved in the management of uterine cervical cancer with several objectives: 1/to assess local and lymph node extension of the initial disease; 2/evaluate treatment response to conservative therapy; 3/detect recurrences. Pelvic MRI is the first-line examination in all these indications. It is the key element for delineation after image fusion when the indication of chemoradiation therapy is made. It is also essential for guiding the placement of applicators and optimising the dosimetry of brachytherapy. The diffusion-weighted acquisition is a sequence sensitive to the motion of water molecule...
Source: Cancer Radiotherapie - April 28, 2020 Category: Cancer & Oncology Authors: Fournier LS, Bats AS, Durdux C Tags: Cancer Radiother Source Type: research

[Preoperative intensity-modulated radiotherapy of rectal cancers: Relevance and modalities].
au J Abstract Preoperative radiotherapy boosted by chemotherapy is a recommended treatment in locally advanced rectal cancers. This treatment is delivered by three dimensional conformal irradiation, which is usually well tolerated but can induce potential toxicity such as rectitis, cystitis and hematologic adverse effects. Intensity-modulated radiotherapy, widely available nowadays, allows optimization of volume covering and sparing of organs at risk such as bladder and bone marrow. This review presents relevant clinical situations and requirements for a beneficial and safe preoperative irradiation of rectal cance...
Source: Cancer Radiotherapie - April 28, 2020 Category: Cancer & Oncology Authors: Randrian V, Biau J, Benoît C, Pezet D, Lapeyre M, Moreau J Tags: Cancer Radiother Source Type: research

[Management of a radiotherapy center during the COVID-19  outbreak: The experience of the Mulhouse hospital centre (France)].
[Management of a radiotherapy center during the COVID-19 outbreak: The experience of the Mulhouse hospital centre (France)]. Cancer Radiother. 2020 Apr 17;: Authors: Ohnleiter T, Piot L, Rogenmuser A, Noirclerc M, Hamlaoui R, Grandgirard A Abstract The COVID-19 outbreak grows exponentially in our country. Despite most of patients develops benign symptoms, cancer patients are at risk of a severe form of the disease. Radiotherapy centres are a potential contamination place due to the number of patients treated and staff present. Their organization during the outbreak period aims to ensure cont...
Source: Cancer Radiotherapie - April 17, 2020 Category: Cancer & Oncology Authors: Ohnleiter T, Piot L, Rogenmuser A, Noirclerc M, Hamlaoui R, Grandgirard A Tags: Cancer Radiother Source Type: research

[Practical update of total dose compensation in case of temporary interruption of external radiotherapy in the COVID-19 pandemic context].
Abstract Overall treatment time is an important factor of local recurrence and indirectly of distant evolution, namely in case of protracted treatments. The current pandemic impacts on the duration of radiotherapy if patients under treatments and synchronously suffering from COVID-19. The models used to compensate the total dose in case of temporary treatment interruption are well known but it is of importance in that pandemic context to update and homogenize clinical practice in order to improve local control without increasing normal tissue complications. PMID: 32307313 [PubMed - as supplied by publisher] (...
Source: Cancer Radiotherapie - April 10, 2020 Category: Cancer & Oncology Authors: Azria D, Hennequin C, Giraud P Tags: Cancer Radiother Source Type: research

Impact of positron emission tomography with computed tomography for image-guided radiotherapy.
Abstract Therapeutic effectiveness in radiotherapy is partly related to correct staging of the disease and then precise therapeutic targeting. Positron emission tomography (PET) allows the stage of many cancers to be determined and therefore is essential before deciding on radiation treatment. The definition of the therapeutic target is essential to obtain correct tumour control and limit side effects. The part of adaptive radiotherapy remains to be defined, but PET by its functional nature makes it possible to define the prognosis of many cancers and to consider radiotherapy adapted to the initial response allowi...
Source: Cancer Radiotherapie - April 10, 2020 Category: Cancer & Oncology Authors: Isnardi V, Thureau S, Vera P Tags: Cancer Radiother Source Type: research

How to work together between nuclear medicine and radiotherapy departments?
Abstract Among the available imaging techniques, functional imaging provided by nuclear medicine departments represents a tool of choice for the oncoradiotherapist for targeting tumour activity, with positron emission tomography as the main modality. Before, during or after radiotherapy, functional imaging helps guide the oncoradiotherapist in making decisions and in the strategic choice of pathology management. Setting up a working group to ensure perfect coordination at all levels is the first step. Key points for a common and coordinated management between the two departments are the definition of an organizati...
Source: Cancer Radiotherapie - April 8, 2020 Category: Cancer & Oncology Authors: Modzelewski R, Gensanne D, Hapdey S, Gouel P, Vera P, Thureau S Tags: Cancer Radiother Source Type: research

Anatomical and functional MR imaging to define tumoral boundaries and characterize lesions in neuro-oncology.
Abstract Neuroimaging and especially MRI has emerged as a necessary imaging modality to detect, measure, characterize and monitor brain tumours. Advanced MRI sequences such as perfusion MRI, diffusion MRI and spectroscopy as well as new post-processing techniques such as automatic segmentation of tumours and radiomics play a crucial role in characterization and follow up of brain tumours. The purpose of this review is to provide an overview on anatomical and functional MRI use for brain tumours boundaries determination and tumour characterization in the specific context of radiotherapy. The usefulness of anatomica...
Source: Cancer Radiotherapie - April 8, 2020 Category: Cancer & Oncology Authors: Benzakoun J, Robert C, Legrand L, Pallud J, Meder JF, Oppenheim C, Dhermain F, Edjlali M Tags: Cancer Radiother Source Type: research

Radiomics: A primer for the radiation oncologist.
CONCLUSION: Radiomics has a great potential to predict clinical outcome and better personalize treatment. But the field is still young and constantly evolving. Improvement in bias reduction techniques and multicenter studies will hopefully allow more robust and generalizable models. PMID: 32265157 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 4, 2020 Category: Cancer & Oncology Authors: Bibault JE, Xing L, Giraud P, El Ayachy R, Giraud N, Decazes P, Burgun A, Giraud P Tags: Cancer Radiother Source Type: research

Imaging issues specific to hadrontherapy (proton, carbon, helium therapy and other charged particles) for radiotherapy planning, setup, dose monitoring and tissue response assessment.
;l G, Valable S Abstract Imaging is critical to each step of precision radiation therapy, i.e. planning, setup, delivery and assessment of response. Hadrontherapy can be considered to deliver more precise dose distribution that may better spare normal tissues from intermediate low doses of radiation. In addition, hadrontherapy using high linear energy transfer ions may also be used for dose escalation on biological target volumes defined by functional imaging. However, the physical characteristics of hadrontherapy also make it more demanding in terms of imaging accuracy and image-based dose calculation. Some of th...
Source: Cancer Radiotherapie - April 1, 2020 Category: Cancer & Oncology Authors: Thariat J, Hérault J, Beddok A, Feuvret L, Dauvergne D, Gérard M, Balosso J, Noël G, Valable S Tags: Cancer Radiother Source Type: research

Interest of positron-emission tomography and magnetic resonance imaging for radiotherapy planning and control.
eau S Abstract Computed tomography (CT) in the treatment position is currently indispensable for planning radiation therapy. Other imaging modalities, such as magnetic resonance imaging (MRI) and positron emission-tomography (PET), can be used to improve the definition of the tumour and/or healthy tissue but also to provide functional data of the target volume. Accurate image registration is essential for treatment planning, so MRI and PET scans should be registered at the planning CT scan. Hybrid PET/MRI scans with a hard plane can be used but pose the problem of the absence of CT scans. Finally, techniques for m...
Source: Cancer Radiotherapie - April 1, 2020 Category: Cancer & Oncology Authors: Créhange G, Soussan M, Gensanne D, Decazes P, Thariat J, Thureau S Tags: Cancer Radiother Source Type: research

Positron-emission tomography-guided radiation therapy: Ongoing projects and future hopes.
Abstract Radiation therapy has undergone significant advances these last decades, particularly thanks to technical improvements, computer science and a better ability to define the target volumes via morphological and functional imaging breakthroughs. Imaging contributes to all three stages of patient care in radiation oncology: before, during and after treatment. Before the treatment, the choice of optimal imaging type and, if necessary, the adequate functional tracer will allow a better definition of the volume target. During radiation therapy, image-guidance aims at locating the tumour target and tailoring the ...
Source: Cancer Radiotherapie - April 1, 2020 Category: Cancer & Oncology Authors: Giraud N, Popinat G, Regaieg H, Tonnelet D, Vera P Tags: Cancer Radiother Source Type: research

[Treatment de-intensification strategies for HPV-driven oropharyngeal cancer: A short review].
te; N Abstract The incidence of oropharyngeal cancer induced by human papillomavirus (HPV) infection is steadily increasing in developed countries. These tumors are more chemoradiosensitive and have a better prognosis than HPV-negative one. In addition, they occur in younger and better-off patients with longer life expectancy. Current radiotherapy and chemotherapy protocols are currently being questioned as they may expose HPV-positive patients to excessive treatment and unnecessary toxic effects. Less intensive treatment regimens could possibly achieve similar efficacy with lower toxicity and improved quality of ...
Source: Cancer Radiotherapie - March 27, 2020 Category: Cancer & Oncology Authors: Lahmamssi C, Guy JB, Benchekroun N, Bouchbika Z, Taoufik N, Jouhadi H, Sahraoui S, Benider A, Ben Mrad M, Jmour O, Bousarsar A, Lan ML, Lei Q, Benna M, Moslemi D, Vallard A, Magné N Tags: Cancer Radiother Source Type: research

Monte Carlo dose calculations of shielding disks with different material combinations in intraoperative electron radiation therapy (IOERT).
CONCLUSIONS: The dose values above and under the shielding disks were acceptable for the four studied shielding types. Demonstrated it is possible to use any of them clinically, while the best shielding disk was the Al/Pb since it has minimum thickness and a small backscatter enhancement. PMID: 32224107 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 26, 2020 Category: Cancer & Oncology Authors: Alhamada H, Simon S, Philippson C, Vandekerkhove C, Jourani Y, Pauly N, Van Gestel D, Reynaert N Tags: Cancer Radiother Source Type: research

[Functional stereotactic radiosurgery: Indications and perspectives].
We present here a review of actual and future indications of functional brain SRS with their level of evidence. All these SRS treatments have to be strictly conducted by trained teams with an excellent collaboration between radiation physicists, medical physicists, neurosurgeons, neurologists, psychiatrists and probably neuroradiologists. PMID: 32220562 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 24, 2020 Category: Cancer & Oncology Authors: Dupic G, Biau J, Lemaire JJ, Ortholan C, Clavelou P, Lapeyre M, Colin P, Khalil T Tags: Cancer Radiother Source Type: research

Construction des mod èles radiobiologiques de type TCP (tumor control probability) et NTCP (normal tissue complication probability) : de la dose à la prédiction des effets cliniques.
Construction des modèles radiobiologiques de type TCP (tumor control probability) et NTCP (normal tissue complication probability) : de la dose à la prédiction des effets cliniques. Cancer Radiother. 2020 Mar 24;: Authors: Chaikh A, Thariat J, Thureau S, Tessonnier T, Kammerer E, Fontbonne C, Dubray B, Balosso J, Fontbonne JM Abstract In radiotherapy, the dose prescription is currently based on discretized dose-effects records that do not take into fully account for the complexity of the patient-dose-response relationship. Their predictive performance on both anti-tumour effi...
Source: Cancer Radiotherapie - March 24, 2020 Category: Cancer & Oncology Authors: Chaikh A, Thariat J, Thureau S, Tessonnier T, Kammerer E, Fontbonne C, Dubray B, Balosso J, Fontbonne JM Tags: Cancer Radiother Source Type: research

Kilovoltage intrafraction monitoring during normofractionated prostate cancer radiotherapy.
CONCLUSION: Automated intrafraction kV imaging can effectively perform autobeam holds due to intrafraction movement of the prostate in the large majority of patients. The additional radiation dose and delivery time are acceptable. This technique may be a cost-effective alternative to electromagnetic transponder guidance. PMID: 32201058 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 19, 2020 Category: Cancer & Oncology Authors: Chasseray M, Dissaux G, Lucia F, Boussion N, Goasduff G, Pradier O, Bourbonne V, Schick U Tags: Cancer Radiother Source Type: research

[Prognosis factors after lung stereotactic body radiotherapy for non-small cell lung carcinoma].
dri M Abstract Lung cancer is the fourth most common cancer in France with a prevalence of 30,000 new cases per year. Lobectomy surgery with dissection is the gold standard treatment for T1-T2 localized non-small cell lung carcinoma. A segmentectomy may be proposed to operable patients but fragile from a respiratory point of view. For inoperable patients or patients with unsatisfactory pulmonary function tests, local treatment with stereotactic radiotherapy may be proposed to achieve local control rates ranging from 85 to 95% at 3-5 years. Several studies have examined prognostic factors after stereotaxic pulmonar...
Source: Cancer Radiotherapie - March 16, 2020 Category: Cancer & Oncology Authors: Yossi S, Nguyen D, Krhili S, Lizée T, Khodri M Tags: Cancer Radiother Source Type: research

Pure abscopal effect of radiotherapy in a salivary gland carcinoma: Case report, literature review, and a search for new approaches.
We report the case of an 84-year-old woman with poorly differentiated non-small cell carcinoma of the right parotid who presented with headache, was found to have a primary right parotid gland cancer as well as metastatic disease, and underwent palliative radiotherapy to the primary site. The patient received no chemotherapy or immunotherapy, but both the primary site and several non-irradiated foci in the lungs regressed or completely resolved. The patient remained free of disease for about one year before progression. The case is a rare instance of abscopal regression of metastatic disease in the absence of pharmacologic...
Source: Cancer Radiotherapie - March 16, 2020 Category: Cancer & Oncology Authors: Ellerin BE, Demandante CGN, Martins JT Tags: Cancer Radiother Source Type: research

Head-and-Neck MRI-only radiotherapy treatment planning: From acquisition in treatment position to pseudo-CT generation.
CONCLUSION: We quantified the image quality decrease induces by using an RT-setup for head-and-neck radiotherapy. To compensate this decrease, an MRI protocol was optimised by using an experimental design. This protocol of 15minutes provides accurate images which could be used for MRI-dose-planning in clinical practice. PMID: 32179006 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 13, 2020 Category: Cancer & Oncology Authors: Largent A, Marage L, Gicquiau I, Nunes JC, Reynaert N, Castelli J, Chajon E, Acosta O, Gambarota G, de Crevoisier R, Saint-Jalmes H Tags: Cancer Radiother Source Type: research

Radiation-induced lung toxicity predictors: Retrospective analysis of 90 patients treated with stereotactic body radiation therapy for stage I non-small-cell lung carcinoma.
CONCLUSION: The discovery of predictive factors for radiation pneumonitis is difficult due to the rarity of this complication, especially with an 8×7.5Gy schedule. Radiation pneumonitis seems to be correlated with the volume irradiated at high doses, which is in contrast to the known knowledge about the organs in parallel. This finding leads us to raise the hypothesis that vessel damage, organs in series, occurring during hypofractionated radiotherapy could be responsible for this toxicity. PMID: 32173269 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 12, 2020 Category: Cancer & Oncology Authors: Menoux I, Antoni D, Mazzara C, Labani A, Charloux A, Quoix E, Falcoz PE, Truntzer P, Noël G Tags: Cancer Radiother Source Type: research

Surgical bed stereotactic radiotherapy of brain metastases: Clinical outcome and predictors of local and distant brain failure.
CONCLUSIONS: Adjuvant SRT was an effective and well-tolerated treatment to control the postoperative risk of recurrence of BM without compromising OS. Positive resection margins and large volumes were predictors factor of local relapse. PMID: 32173270 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 12, 2020 Category: Cancer & Oncology Authors: Mousli A, Bihin B, Gustin T, Koerts G, Mouchamps M, Daisne JF Tags: Cancer Radiother Source Type: research

Adolescents and young adults with classical Hodgkin lymphoma in North Tunisia: Insights from an adult single-institutional study.
CONCLUSION: The treatment approach used is well tolerated by adult patients. However, the AYA patients and particularly adolescent subgroup had more advanced disease at diagnosis and should be treated more intensively in dedicated units. RT dose
Source: Cancer Radiotherapie - March 11, 2020 Category: Cancer & Oncology Authors: Zawati I, Adouni O, Finetti P, Manai M, Manai M, Gamoudi A, Birnbaum D, Bertucci F, Mezlini A Tags: Cancer Radiother Source Type: research

Intraoperative partial irradiation for highly selected patients with breast cancer: Results of the INTRAOBS prospective study.
Abstract PURPOSE: To evaluate our long-term experience on one-day breast intraoperative radiotherapy (IORT) given as sole radiation treatment to selected patients with breast cancer. METHODS AND MATERIALS: Inclusion criteria of INTRAOBS study (prospective observational study) were: ER+ T1N0 unifocal ductal carcinoma; absence of lymphovascular invasion or of extensive intraductal component (Scarff-Bloom-Richardson grade III and HER2+++ excluded). Two different linacs were used (20Gy/1 fraction): one dedicated electron linac (
Source: Cancer Radiotherapie - March 11, 2020 Category: Cancer & Oncology Authors: Lemanski C, Bourgier C, Draghici R, Thezenas S, Morel A, Rouanet P, Colombo PE, Mourregot A, Delmond L, Fenoglietto P, Ailleres N, Azria D, Gutowski M Tags: Cancer Radiother Source Type: research

A brief history of contact X-ray brachytherapy 50  kVp.
A brief history of contact X-ray brachytherapy 50 kVp. Cancer Radiother. 2020 Mar 11;: Authors: Gérard JP, Dejean C, Montagne L, Benezery K, Doyen J, Hannoun Levi JM Abstract Contact X ray brachytherapy 50 kVp was initiated in the 1930s with the Siemens unit and popularized with the Philips unit in the 1950s. A renaissance was seen in the early 2000s with the Intrabeam™ unit for breast IORT. Presently the Papillon™ systems thanks to its high dose rate (>10Gy/mn) can be used to treat breast (IORT), skin, eyelid and rectal cancers. Future developments are expected to cons...
Source: Cancer Radiotherapie - March 11, 2020 Category: Cancer & Oncology Authors: Gérard JP, Dejean C, Montagne L, Benezery K, Doyen J, Hannoun Levi JM Tags: Cancer Radiother Source Type: research

Independent 6D quality assurance of stereotactic radiotherapy repositioning on linacs.
CONCLUSION: Results demonstrate that the linac equipped with a 6DOF robotic positioner and CBCT imaging satisfies requirements for SRT. Our methodology, based on a modified Winston-Lutz quality control, allowed us to quantitatively assess end-to-end accuracy of a linac in order to safely deliver SRT. PMID: 32165115 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 9, 2020 Category: Cancer & Oncology Authors: Dumas JL, Fawzi M, Masset H, Losa S, Dal R, Pierrat N, de Marzi L Tags: Cancer Radiother Source Type: research

The role of postoperative radiotherapy (PORT) in pulmonary large cell neuroendocrine carcinoma (PLCNEC).
Abstract PURPOSE: To assess the long-term survivals and related prognostic indicators of patients with pulmonary large cell neuroendocrine carcinoma (PLCNEC), and determine the prognostic value of post-operative radiotherapy in PLCNEC. MATERIALS AND METHODS: Patients diagnosed with PLCNEC between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database were included in our study. Cox proportional hazard model was used to evaluate the factors related to overall survival (OS). Propensity score matching analysis (PSM analysis) was used to balance the variables differences between postop...
Source: Cancer Radiotherapie - March 7, 2020 Category: Cancer & Oncology Authors: Gang Jin, Lili Xue, Xiang Song Tags: Cancer Radiother Source Type: research

Tolerance and efficacy of dose escalation using IMRT combined with chemotherapy for unresectable esophageal carcinoma: Long-term results of 51  patients.
CONCLUSION: We demonstrated in this study that dose escalation using IMRT in combination with platin-based chemotherapy as a definitive treatment for esophageal carcinoma is safe and results in higher loco-regional and control survival when compared to previously reported data. PMID: 32156457 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 7, 2020 Category: Cancer & Oncology Authors: Modesto A, Dalmasso C, Lusque A, Vieillevigne L, Izar F, Moyal E, Carrère N, Guimbaud R, Rives M Tags: Cancer Radiother Source Type: research

[Radiotherapy for ovarian carcinoma management: Literature review].
Abstract Ovarian cancer is the fifth most common cancer in women in France with 4714 new cases in 2017. More than 70% of patients whose disease is initially locally advanced will present locoregional or distant recurrence. Therapeutic options in this situation are not consensual. They are based on chemotherapy possibly associated with an iterative cytoreductive surgery when it is bearable by the patient. The place of radiotherapy in the management of the disease is hidden in the vast majority of national or international standards. We conducted a general review of the literature to clarify the role of irradiation ...
Source: Cancer Radiotherapie - March 6, 2020 Category: Cancer & Oncology Authors: Yossi S, Nguyen D, Khodri M, Reure J, Cervellera M, Lamberth F, Marchand V, Mammar V, Renoult F, Louet E, Coquard R, Barbet N, Lorchel F Tags: Cancer Radiother Source Type: research

[Biologic effects of high doses per fraction].
Abstract The radiobiological concepts described for conventional doses per fraction (1.8 to 2Gy) seem difficult to translate to high doses per fraction radiobiology. In fact, specific mechanisms are involved during high dose per fraction irradiation, involving vascular microenvironment damage and anti tumor immune response. The "5R's" of "classical" radiobiology (factors influencing the response of healthy or cancer cells to irradiation) seem to play a less important role in case of high doses per fraction. In addition, applicability of the linear quadratic model in this context is debated. It ...
Source: Cancer Radiotherapie - February 20, 2020 Category: Cancer & Oncology Authors: Grellier N, Belkacemi Y Tags: Cancer Radiother Source Type: research

[Comparison between Stump Cylinder and custom mold, effect of the shape of the applicator on the dose distribution].
CONCLUSION: The underdosing obtained using the Stump Cylinder was due to the shape of upper part of the cylinder which was not conform with the shape of the vaginal vault in women. A better protection of the organs at risk was observed with the Stump Cylinder since the dose taken by the rectum and bladder using a custom mold can reach the tolerance limits. PMID: 32063417 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - February 13, 2020 Category: Cancer & Oncology Authors: Jreij M, Al Kattar Z, Charara J Tags: Cancer Radiother Source Type: research

[Measurement of out-of-field dose to the uterus during proton therapy of the head and neck].
Abstract The decision to irradiate during pregnancy is based on a risk benefit compromise of two kinds: maternal risk and fetal risk. The aim of this work is to determine the foetal risk, and uterine dose measurement in proton therapy. Foetal exposure during treatment is linked to two sources: the treatment phase, and the repositioning phase. An Alderson-Rando anthropomorphic ghost (170cm, 74kg) was positioned on the table in the treatment position. A tissue-equivalent proportional counter (TEPC), adapted to the analysis of complex radiation fields (neutron and photonics), was used to determine the irradiation rel...
Source: Cancer Radiotherapie - February 12, 2020 Category: Cancer & Oncology Authors: le Guevelou J, Trompier F, Villagrasa C, Vela A, Isambert A, Herault J, Thariat J Tags: Cancer Radiother Source Type: research

Microbial etiology, susceptibility profile of postradiation nasopharyngeal necrosis patients with nasopharyngeal carcinoma.
CONCLUSION: Our results provide an overall picture of the microbiology and drug susceptibility patterns for NPC patients with PRNN and could help implement guidelines for more rational treatment and improve therapeutic outcome. PMID: 32057645 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - February 11, 2020 Category: Cancer & Oncology Authors: Wang L, Yang J, Peng SY, Li GQ, Tu ZW Tags: Cancer Radiother Source Type: research

[Indications and outlooks of radiohormonal therapy of high-risk prostate cancers].
iot S, Pasquier D Abstract Prostate cancer is a sensitive adenocarcinoma, in more than 80% of cases, to chemical castration, due to its hormone dependence. Locally advanced and/or high-risk cancer is defined based on clinical stage, initial prostate specific antigen serum concentration value or high Gleason score. Hormone therapy associated with radiation therapy is the standard of management and improves local control, reduces the risk of distant metastasis and improves specific and overall survival. Duration of hormone therapy, dose level of radiation therapy alone or associated with brachytherapy are controvers...
Source: Cancer Radiotherapie - February 11, 2020 Category: Cancer & Oncology Authors: Latorzeff I, Sargos P, Créhange G, Belkacémi Y, Azria D, Hasbini A, Dubergé T, Toledano A, Graff-Cailleaud P, Chapet O, Hennequin C, de Crevoisier R, Supiot S, Pasquier D Tags: Cancer Radiother Source Type: research