Impact of field number and beam angle on ERE for lung stereotactic body radiotherapy with 1.5T MR-Linac
CONCLUSION: The plan quality can be significantly changed by the presence of a 1.5T TMF for lung SBRT with MR-Linac. The selection of optimal fields number and beam angle can substantially reduce or even eliminate these changes, without deteriorating overall plan quality.PMID:33622638 | DOI:10.1016/j.canrad.2021.01.006 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - February 24, 2021 Category: Cancer & Oncology Authors: S Ding H Liu B Wang Y Li R Li B Liu Y Xia X Huang Source Type: research

Impact of field number and beam angle on ERE for lung stereotactic body radiotherapy with 1.5T MR-Linac
CONCLUSION: The plan quality can be significantly changed by the presence of a 1.5T TMF for lung SBRT with MR-Linac. The selection of optimal fields number and beam angle can substantially reduce or even eliminate these changes, without deteriorating overall plan quality.PMID:33622638 | DOI:10.1016/j.canrad.2021.01.006 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - February 24, 2021 Category: Cancer & Oncology Authors: S Ding H Liu B Wang Y Li R Li B Liu Y Xia X Huang Source Type: research

Impact of field number and beam angle on ERE for lung stereotactic body radiotherapy with 1.5T MR-Linac
CONCLUSION: The plan quality can be significantly changed by the presence of a 1.5T TMF for lung SBRT with MR-Linac. The selection of optimal fields number and beam angle can substantially reduce or even eliminate these changes, without deteriorating overall plan quality.PMID:33622638 | DOI:10.1016/j.canrad.2021.01.006 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - February 24, 2021 Category: Cancer & Oncology Authors: S Ding H Liu B Wang Y Li R Li B Liu Y Xia X Huang Source Type: research

Impact of field number and beam angle on ERE for lung stereotactic body radiotherapy with 1.5T MR-Linac
CONCLUSION: The plan quality can be significantly changed by the presence of a 1.5T TMF for lung SBRT with MR-Linac. The selection of optimal fields number and beam angle can substantially reduce or even eliminate these changes, without deteriorating overall plan quality.PMID:33622638 | DOI:10.1016/j.canrad.2021.01.006 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - February 24, 2021 Category: Cancer & Oncology Authors: S Ding H Liu B Wang Y Li R Li B Liu Y Xia X Huang Source Type: research

Long-term outcome of Stereotactic Body Radiation Therapy for patient with unresectable liver metastases from colorectal cancer
CONCLUSION: Stereotactic body radiation therapy is an effective and well-tolerated treatment that allow high LC for liver metastases from colorectal cancer during the first two years. A prescription dose of 45Gy in 3 fractions to the 80% isodose line with a risk adapted schedule to respect Organ At Risk constraints allows a low rate of toxicity.PMID:33618909 | DOI:10.1016/j.canrad.2021.01.004 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - February 23, 2021 Category: Cancer & Oncology Authors: J F Py J Salleron F Courrech V Beckendorf V Crois é-Laurent D Peiffert G Vogin A S Dietmann Source Type: research

Long-term outcome of Stereotactic Body Radiation Therapy for patient with unresectable liver metastases from colorectal cancer
CONCLUSION: Stereotactic body radiation therapy is an effective and well-tolerated treatment that allow high LC for liver metastases from colorectal cancer during the first two years. A prescription dose of 45Gy in 3 fractions to the 80% isodose line with a risk adapted schedule to respect Organ At Risk constraints allows a low rate of toxicity.PMID:33618909 | DOI:10.1016/j.canrad.2021.01.004 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - February 23, 2021 Category: Cancer & Oncology Authors: J F Py J Salleron F Courrech V Beckendorf V Crois é-Laurent D Peiffert G Vogin A S Dietmann Source Type: research

Ablative radiosurgery for cardiac arrhythmias  - A systematic review
Cancer Radiother. 2021 Feb 13:S1278-3218(21)00025-1. doi: 10.1016/j.canrad.2021.01.009. Online ahead of print.ABSTRACTStereotactic body radiotherapy (SBRT) is a high precision technique that is commonly used for malignant lesions in lung, liver, pancreas and spine. Recent reports suggest promise in use of SBRT as a tool in atrial and ventricular cardiac arrhythmias. The present systematic review deals with the use of SBRT technology for this novel indication. A PubMed search was done for articles published between 1990 and 2020. All original articles, case reports, case series of treated patients were included in the analy...
Source: Cancer Radiotherapie - February 16, 2021 Category: Cancer & Oncology Authors: A Munshi Source Type: research

Ablative radiosurgery for cardiac arrhythmias  - A systematic review.
Ablative radiosurgery for cardiac arrhythmias - A systematic review. Cancer Radiother. 2021 Feb 13;: Authors: Munshi A Abstract Stereotactic body radiotherapy (SBRT) is a high precision technique that is commonly used for malignant lesions in lung, liver, pancreas and spine. Recent reports suggest promise in use of SBRT as a tool in atrial and ventricular cardiac arrhythmias. The present systematic review deals with the use of SBRT technology for this novel indication. A PubMed search was done for articles published between 1990 and 2020. All original articles, case reports, case series of t...
Source: Cancer Radiotherapie - February 13, 2021 Category: Cancer & Oncology Authors: Munshi A Tags: Cancer Radiother Source Type: research

[Proposal for the delineation of postoperative primary clinical target volumes in ethmoid cancers].
This article does not discuss the indications of external radiotherapy but specifies the volumes to be delineated if radiotherapy is considered. PMID: 33546996 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - February 2, 2021 Category: Cancer & Oncology Authors: Guillemin F, Miroir J, Piram L, Bellini R, Saroul N, Pham Dang N, Boisselier P, Bourhis J, Calugaru V, Coutte A, Graff P, Pointreau Y, Racadot S, Sun XS, Thariat J, Biau J, Lapeyre M Tags: Cancer Radiother Source Type: research

Angiosarcoma associated with radiation therapy after treatment of breast cancer. Retrospective study on ten years.
CONCLUSION: The median latency was 10 (4-24) years, the incidence of AAR in the East Belgian area was 0.09% of the patients irradiated on the same period. Patients were treated by surgery with wide local excision with or without reconstructive surgery, without radiotherapy and chemotherapy treatment. Kaplan-Meier analysis showed median overall survival of 61.8 months, patient survival of 55.6% at one year and 29.6% at five years. With the constant progress of medicine and its technologies, it would be possible to limit the occurrence of AAR or to diagnose it at an earlier stage. PMID: 33487559 [PubMed - as supplied by...
Source: Cancer Radiotherapie - January 21, 2021 Category: Cancer & Oncology Authors: Verdin V, Mattart L, Cusumano PG, De Hertogh O, De Meester C, Francart D, Kirova YM, Nelissen X, Sacino F, Vanderick J, Weerts J, Markiewicz S Tags: Cancer Radiother Source Type: research

Brachytherapy boost (BT-boost) or stereotactic body radiation therapy boost (SBRT-boost) for high-risk prostate cancer (HR-PCa).
Abstract Systematic review for the treatment of high-risk prostate cancer (HR-PCa, D'Amico classification risk system) with external body radiation therapy (EBRT)+brachytherapy-boost (BT-boost) or with EBRT+stereotactic body RT-boost (SBRT-boost). In March 2020, 391 English citations on PubMed matched with search terms "high risk prostate cancer boost". Respectively 9 and 48 prospective and retrospective studies were on BT-boost and 7 retrospective studies were on SBRT-boost. Two SBRT-boost trials were prospective. Only one study (ASCENDE-RT) directly compared the gold standard treatment [dose-escalation...
Source: Cancer Radiotherapie - January 18, 2021 Category: Cancer & Oncology Authors: Peyraga G, Lizee T, Khalifa J, Blais E, Mauriange-Turpin G, Supiot S, Krhili S, Tremolieres P, Graff-Cailleaud P Tags: Cancer Radiother Source Type: research

[Application of the « Junior Doctor » status in Radiation Oncology].
[Application of the « Junior Doctor » status in Radiation Oncology]. Cancer Radiother. 2021 Jan 15;: Authors: Bourbonne V, Michalet M, Lopez H, Pradier O, Spano JP, Giraud P Abstract Introduced in 2017, the reform of the 3rd cycle has modified the organization of the residency in all specialties, and in particular radiation oncology. The residency was thus divided into 3 phases with increasing knowledge and responsibilities. The latter, carried out under the status of "junior doctor", created and defined by decree n°2018-571 of July 3, 2018 and the decree of January...
Source: Cancer Radiotherapie - January 15, 2021 Category: Cancer & Oncology Authors: Bourbonne V, Michalet M, Lopez H, Pradier O, Spano JP, Giraud P Tags: Cancer Radiother Source Type: research

I125 irradiation stent for treatment of hepatocellular carcinoma with portal vein thrombosis: A meta-analysis.
Abstract PURPOSE: A meta-analysis aimed to systematically evaluate the safety and efficiency of I125 irradiation stent placement for patients with hepatocellular carcinoma (HCC) combined with portal vein tumor thrombosis (PVTT). MATERIALS AND METHODS: The Cochrane library, PubMed/Medline, EMBASE, CNKI, Wanfang Data and CQVIP were systematically screened out from the earliest to December 2019. The qualities of all included studies were assessed. The primary endpoints were the 6-month, 12-month stent cumulative patency rate and 6-month, 12-month, 24-month overall survival rate while the secondary endpoints were...
Source: Cancer Radiotherapie - January 14, 2021 Category: Cancer & Oncology Authors: Li S, Guo JH, Lu J, Wang C, Wu H, Wang H, Zha J, Fan R Tags: Cancer Radiother Source Type: research

Stereotactic radiotherapy for hepatocellular carcinoma induced by hepatitis C and the relationships of changes in carbohydrate antigen 19-9 with AFP and PIVKA-II.
CONCLUSIONS: This is the first investigation of changes in CA 19-9 levels after SBRT for HCC induced by hepatitis C. Characteristic changes in CA 19-9, AFP, and PIVKA-II levels were observed as responses after treatment. As for its correlations with tumour markers, the acute responses of PIVKA-II tended to be slower than those of CA 19-9 and AFP. Although the sample size was small, our findings raise the possibility that measuring these 3 biomarkers after SBRT may be useful for monitoring patients for HCC recurrence. PMID: 33455875 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 14, 2021 Category: Cancer & Oncology Authors: Maebayashi T, Ishibashi N, Aizawa T, Sakaguchi M, Okada M Tags: Cancer Radiother Source Type: research

Evaluation of margins in pelvic lymph nodes and prostate radiotherapy and the impact of bladder and rectum on prostate position.
CONCLUSIONS: We recommend CTV to PTV margins of 8mm, 6mm and 9mm in AP, ML and SI directions for prostate. And, we suggest 4mm and 5mm for external and common iliac vessels respectively. We also prefer registration based on bony landmarks to minimize bowel irradiation. More CBCT scans should be performed during the first 3weeks and especially the first week to check rectum volume. PMID: 33454191 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 13, 2021 Category: Cancer & Oncology Authors: Marnouche EA, Hadadi K, Abdelhak M, Benlemlih M, Hommadi M, Zaghba N, Andaloussi Saghir K, Elmarjany M, Sifat H, Mansouri H Tags: Cancer Radiother Source Type: research

Radio-induced esophageal motility disorders: An unrecognized diagnosis.
CONCLUSION: EMD should be suspected in patients with a history of cervical or thoracic RT in case of upper GI symptoms with normal endoscopy. In these particular patients, a manometric diagnosis that can explain their symptoms is of particular importance to limit anxiety linked to unexplained troubles. PMID: 33454192 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 13, 2021 Category: Cancer & Oncology Authors: Vitton V, Andrianjafy C, Luciano L, Gonzalez JM, Padovani L Tags: Cancer Radiother Source Type: research

[Low-dose irradiation of non-malignant diseases: Did we throw the baby out with the bathwater?]
Abstract The irradiation of non-malignant diseases, essentially for anti-inflammatory purpose, have been largely proposed and performed worldwide until the 1970-80s. At that time, the better assessment of the radio-induced malignancies, essentially in children and young patients, as well as the efficacy of the new anti-inflammatory drugs (steroids and non-steroids), led to the almost disappearance of those techniques, at least in France. In contrast, our German colleagues are still going on treating about 50,000 patients per year for non-malignant (more or less severe) diseases. After a short historical overv...
Source: Cancer Radiotherapie - January 12, 2021 Category: Cancer & Oncology Authors: Cosset JM, Deutsch E Tags: Cancer Radiother Source Type: research

Study of the predictors for radiation pneumonitis in patient with non-small cell lung cancer received radiotherapy after pneumonectomy.
Abstract PURPOSE: To identify the valuable predictors of grade≥2 radiation pneumonitis (RP) in patient treated with radiotherapy after pneumonectomy for non-small cell lung cancer (NSCLC); and to construct a nomogram predicting the incidence of grade≥2 RP in such patients. PATIENTS AND METHODS: We reviewed 82 patients with NSCLC received radiotherapy after pneumonectomy from 2008 to 2018. The endpoint was grade≥2 RP. Univariate and multivariate regression analysis were conducted to evaluate significant factors of grade≥2 RP. Receiver operating characteristic (ROC) curve was used to establish optim...
Source: Cancer Radiotherapie - January 11, 2021 Category: Cancer & Oncology Authors: Yu JH, Wang CL, Liu Y, Wang JM, Lv CX, Liu J, Zhang Q, Fu XL, Cai XW Tags: Cancer Radiother Source Type: research

[Risk management and (health) crisis: How to assess the impact of changing a prescription over time in radiotherapy].
PMID: 33446420 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 11, 2021 Category: Cancer & Oncology Authors: Colin G, Coucke P Tags: Cancer Radiother Source Type: research

Psychological and physical impact in women treated for breast cancer: Need for multidisciplinary surveillance and care provision.
CONCLUSIONS: Not only FCR, but also issues such as fatigue, pain, psychological difficulties, and difficulties in marriage and sexual life all call for a psycho-oncological follow-up. Clinical and radio-senological surveillance is essential, but it absolutely must be accompanied by a multidisciplinary follow-up, with central importance to psychological care. PMID: 33446421 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 11, 2021 Category: Cancer & Oncology Authors: Vandendorpe B, Drouet Y, Ramiandrisoa F, Guilbert P, Costa B, Servagi-Vernat S Tags: Cancer Radiother Source Type: research

Intramedullary spinal cord metastases: Report of three cases and review of the literature.
Abstract Intramedullary spinal cord metastases (ISCM) is a rare, but devastating complication of malignant disease. Prognosis is poor, with an overall median survival (OS) of 4 months from the time of diagnosis. Yet, ISCMs are being increasingly diagnosed, related to advances and increased use of imaging and therapies that prolong survival in patients with cancer. Prompt and accurate diagnosis of ISCM is necessary for effective treatment, and magnetic resonance imaging (MRI) is the preferred imaging technique. The optimal management of these patients is controversial because of the multitude of clinical circumstan...
Source: Cancer Radiotherapie - January 9, 2021 Category: Cancer & Oncology Authors: Hommadi M, Belemlih M, Marnouch E, Maghous A, Zaghba N, Hamidi FZ, Bazzine A, Saghir KA, Elmarjany M, Sifat H, Hadadi K, Mansouri H Tags: Cancer Radiother Source Type: research

The efficacy of hypofractionated radiotherapy (HFRT) with  concurrent and adjuvant temozolomide in newly diagnosed glioblastoma: A meta-analysis.
The efficacy of hypofractionated radiotherapy (HFRT) with concurrent and adjuvant temozolomide in newly diagnosed glioblastoma: A meta-analysis. Cancer Radiother. 2021 Jan 09;: Authors: Guo L, Li X, Chen Y, Liu R, Ren C, Du S Abstract PURPOSE: The efficacy of hypofractionated radiotherapy (HFRT) in glioblastoma (GBM) without age restrictions remains unclear. The aim of this meta-analysis is to access the survival outcomes of HFRT in these patients. METHODS: A comprehensive electronic literature search of PubMed, Web of Science and Cochrane Library was conducted up to June 1, 2020. The m...
Source: Cancer Radiotherapie - January 9, 2021 Category: Cancer & Oncology Authors: Guo L, Li X, Chen Y, Liu R, Ren C, Du S Tags: Cancer Radiother Source Type: research

[Repeated irradiation of brain metastases under stereotactic conditions: A review of the literature].
Abstract Stereotactic radiotherapy has become a standard in the management of patients with brain metastases; its main interest is to differ whole brain radiotherapy, provider of neurocognitive toxicity and to increase the rate of local control. The repetition of radiotherapy sessions under stereotactic conditions is not codified, neither on the number of technically and clinically possible sessions, nor on the maximum total number or volume of metastases to be treated. The purpose of this review is to analyse the data in the literature concerning repeated irradiations under stereotactic conditions. The second rei...
Source: Cancer Radiotherapie - January 8, 2021 Category: Cancer & Oncology Authors: Kuntz L, Noel G Tags: Cancer Radiother Source Type: research

Comparison of different TBI techniques in terms of dose homogeneity  - review study.
Comparison of different TBI techniques in terms of dose homogeneity - review study. Cancer Radiother. 2021 Jan 08;: Authors: Hoseinnezhad Zarghani E, Geraily G, Hadisinia T Abstract Total body irradiation (TBI) is a kind of external beam radiotherapy, used in conjunction with chemotherapy with the purpose of immunosuppression. Since the target in TBI is the whole body, so achieving uniform dose distribution throughout the entire body during TBI is necessary. As recommended by AAPM dose variation must be within ±10% of the prescription dose. With the evidences from literature there is ...
Source: Cancer Radiotherapie - January 8, 2021 Category: Cancer & Oncology Authors: Hoseinnezhad Zarghani E, Geraily G, Hadisinia T Tags: Cancer Radiother Source Type: research

[Claude-Michel Lalanne (1919-2017)].
PMID: 33431296 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 8, 2021 Category: Cancer & Oncology Authors: Lagrange JL Tags: Cancer Radiother Source Type: research

In vitro effects of Trastuzumab Emtansine (T-DM1) and concurrent irradiation on HER2-positive breast cancer cells.
CONCLUSIONS: Although there is a linear correlation between intrinsic HER2 expression and radioresistance, the results indicated that T-DM1 is not a radiation-sensitizer under the experimental conditions of this study that allowed cell survival. However, further investigations are needed, in particular in vivo studies before reaching a final conclusion. PMID: 33431297 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 8, 2021 Category: Cancer & Oncology Authors: Mignot F, Kirova Y, Verrelle P, Teulade-Fichou MP, Megnin-Chanet F Tags: Cancer Radiother Source Type: research

Cardiac substructures exposure in left-sided breast cancer radiotherapy: Is the mean heart dose a reliable predictor of cardiac toxicity?
This study aimed to assess radiation dose distribution to cardiac subvolumes in left-sided breast cancer radiotherapy (LBCRT) and to clarify whether the mean heart dose (MHD) reliably reflects cardiac substructures exposure. MATERIALS AND METHODS: Fifty women referred for adjuvant LBCRT were prospectively evaluated. All patients received 3D-conformal hypofractionated radiotherapy (40Gy delivered in 15 fractions of 2.67Gy±boost of 13.35Gy). Cardiac substructures were contoured using the F. Duane's cardiac atlas. Dose distribution to cardiac chambers, left main (LM), left anterior descending (LAD), left circ...
Source: Cancer Radiotherapie - January 7, 2021 Category: Cancer & Oncology Authors: Naimi Z, Moujahed R, Neji H, Yahyaoui J, Hamdoun A, Bohli M, Kochbati L Tags: Cancer Radiother Source Type: research

[Intra and extra hepatic cholangiocarcinomas radiation therapy].
Abstract Cholangiocarcinomas are digestive tumors whose incidence remains low and have poor prognosis. The benefits of adjuvant radiochemotherapy and radiotherapy have never been demonstrated in any phase III randomized controlled trial. Chemotherapy with capecitabine 6 months is the standard of care in adjuvant setting. Radiochemotherapy is validated in R1 patients. It is not recommended in neoadjuvant situations given the lack of evidence. Chemotherapy and radiochemotherapy are validated in adjuvant or locally advanced diseases. Stereotactic radiation therapy offers an interesting perspective, at the cost of sig...
Source: Cancer Radiotherapie - January 7, 2021 Category: Cancer & Oncology Authors: Moreau J, Lapeyre M, Benoit C, Pezet D, Biau J Tags: Cancer Radiother Source Type: research

MRI prostate contouring is not impaired by the use of a radiotherapy image acquisition set-up. An intra- and inter-observer paired comparative analysis with diagnostic set-up images.
CONCLUSION: Prostate and rectum contours did not differ significantly when using diagnostic or radiotherapy MRI acquisition set-ups. PMID: 33423967 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 7, 2021 Category: Cancer & Oncology Authors: Sabater S, Pastor-Juan MR, Andres I, López-Martinez L, Lopez-Honrubia V, Tercero-Azorin MI, Sevillano M, Lozano-Setien E, Jimenez-Jimenez E, Berenguer R, Rovirosa A, Castro-Larefors S, Magdalena Marti-Laosa M, Roche O, Martinez-Terol F, Arenas M Tags: Cancer Radiother Source Type: research

[Stereotactic body radiotherapy for locally advanced pancreatic cancer: A systemic review].
Abstract Stereotactic body radiation therapy (SBRT) for locally advanced pancreatic cancer (LAPC) is an emerging treatment option. Most studies showed local control of approximately 75% with no evidence of improved overall survival. Gastrointestinal toxicities could be significant, ranging up to 22% for acute toxicities≥grade 3+ and 44% for late toxicities≥grade 3+. Currently, no standardized guidelines for treatment and management scheme. We conducted a systemic review of published prospective and retrospective trials to evaluate the efficacy, safety, technical data, and discuss future directions. PMID...
Source: Cancer Radiotherapie - January 7, 2021 Category: Cancer & Oncology Authors: Tonneau M, Lacornerie T, Mirabel X, Pasquier D Tags: Cancer Radiother Source Type: research

Prognostic value of platelet-associated biomarkers in rectal cancer patients received neoadjuvant chemoradiation: A retrospective study.
CONCLUSION: In LARC patients with NACRT, the pre-PLR and pre-LMR are independent prognostic factors for OS, while pre-MPV has predictive value for DFS. PMID: 33423969 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 7, 2021 Category: Cancer & Oncology Authors: Wang P, Wang Z, Liu Y, Xie J, Ren Y Tags: Cancer Radiother Source Type: research

Breast cancer radioresistance may be overcome by osteopontin gene knocking out with CRISPR/Cas9 technique.
CONCLUSION: Our results demonstrated that after knocking out the OPN gene, the MDA-MB-231 cells showed a significant radiosensitivity. Therefore, the OPN knock out in combination with conventional radiotherapy, may become an efficient therapeutic target in the future. PMID: 33422414 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 6, 2021 Category: Cancer & Oncology Authors: Behbahani RG, Danyaei A, Teimoori A, Neisi N, Tahmasbi MJ Tags: Cancer Radiother Source Type: research

Can we define any marker associated with brain failure in patients with locally advanced non-small cell lung cancer?
Abstract PURPOSE: To define the factors which may be related to brain metastasis (BM) in patients with locally advanced non-small cell lung cancer (LA-NSCLC) who developed brain metastases after definitive treatment. PATIENTS AND METHODS: A total of 208 patients with LA-NSCLC, without BM who received definitive radiotherapy (RT) or RT+chemotherapy (CT) between January 2005 and January 2016 were evaluated retrospectively. Platelet, neutrophil, lymphocyte counts, LDH, CRP, Hb levels, neutrophil-to-lymphocyte radio (NLR), platelet-to-lymphocyte radio (PLR), advanced lung cancer inflammation index (ALI) and FDG-P...
Source: Cancer Radiotherapie - January 6, 2021 Category: Cancer & Oncology Authors: Sert F, Cosgun G, Yalman D, Ozkok S Tags: Cancer Radiother Source Type: research

Application of a multi-institutional nomogram predicting salvage whole brain radiation-free survival to patients treated with postoperative stereotactic radiotherapy for brain metastases.
CONCLUSION: This nomogram-predicted well the 12 months WFS but its discriminative power was quite low. This underlines the limits of this kind of predictive tool and leads us to consider the use of big data analysis in the future. PMID: 33422416 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 6, 2021 Category: Cancer & Oncology Authors: Mousli A, Bihin B, Gustin T, Koerts G, Mouchamps M, Daisne JF Tags: Cancer Radiother Source Type: research

Predictive factors associated with complete pathological response after neoadjuvant treatment for rectal cancer.
Abstract PURPOSE: A proportion of 10 to 30% of patients treated by chemoradiotherapy followed by total mesorectal excision surgery for a locally advanced rectal cancer can achieve a complete pathological response. We aimed to identify predictive factors associated with complete pathological response or no response and to assess the impact of each response on survival rates. PATIENTS AND METHODS: Patients treated with long course chemoradiotherapy for locally advanced and/or node positive rectal cancer from 2010 to 2016 were retrospectively reviewed. Statistical analysis was carried out to determine predictors...
Source: Cancer Radiotherapie - January 6, 2021 Category: Cancer & Oncology Authors: Hajer J, Rim A, Ghorbel A, Amani Y, Ines L, Asma B, Chiraz N Tags: Cancer Radiother Source Type: research

[Plan of the day adaptive radiotherapy for bladder cancer: Dosimetric and clinical results].
CONCLUSION: The ART technique using a PoD strategy showed a reduction of the irradiated healthy tissue volume while maintaining a similar bladder coverage, with an acceptable rate of toxicity. PMID: 33422418 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 6, 2021 Category: Cancer & Oncology Authors: Cabaillé M, Gaston R, Belhomme S, Giraud A, Rouffilange J, Roubaud G, Sargos P Tags: Cancer Radiother Source Type: research

Volumetric and dosimetric impact of MRI in delineation of gross tumor volume of non-spinal vertebral metastases treated with stereotactic ablative radiation therapy.
Abstract PURPOSE: To investigate the Gross Tumor Volumes (GTV) and its dosimetric impact of magnetic resonance imaging (MRI) assisted contouring for non-spinal metastasis treated with stereotactic ablative body radiotherapy (SABR). MATERIAL AND METHODS: Five observer contours on CT (GTVCT) and CT+MR (GTVCT+MR) were evaluated against expert team contours (GTVEC) for 14 selected cases. Dice Similarity Index (DSC) and Geographical Miss Index (GMI) quantify observer variation. We also analyze the maximum dose (Dmax) and dose received by 0.35cc (D0.35cc) of the spinal cord (SC) for GTVCT and GTVCT+MR, where optimi...
Source: Cancer Radiotherapie - January 6, 2021 Category: Cancer & Oncology Authors: Ilamurugu A, Chandrasekaran A, Ayyalusamy A, Prasanna Satpathy S, Reddy JM, Arora S, Subramanian S, Velayudham R Tags: Cancer Radiother Source Type: research

[Dosimetric impact of hydrogel spacer use for stereotactic body radiotherapy of localised prostate cancer].
CONCLUSION: Spacer procedure under local anesthesia was well tolerated. Hydrogel spacer allowed to reduce doses to the rectum while improving PTV coverage. PMID: 33419606 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 5, 2021 Category: Cancer & Oncology Authors: Ung M, Bossi A, Abbassi L, Vautier J, Anthonipillai V, Chevé M, Blanchard P Tags: Cancer Radiother Source Type: research

A comparison between raltitrexed plus cisplatin and docetaxel plus cisplatin in concurrent chemoradiation for non-surgical esophageal squamous cell carcinoma.
CONCLUSIONS: Even RP and DP groups have the similar survival outcomes and toxicity, raltitrexed/cisplatin get a higher complete response rate. Our study suggests that raltitrexed combined with cisplatin is a safe and effective concurrent chemotherapy regimen and it might be used as an alternative for cisplatin/5-FU and cisplatin/docetaxel in CCRT for EC patients. PMID: 33419607 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 5, 2021 Category: Cancer & Oncology Authors: Xia X, Liu Z, Cai B, Di X, Sun X, Ge X Tags: Cancer Radiother Source Type: research

MRI-based brain structural changes following radiotherapy of Nasopharyngeal Carcinoma: A systematic review.
CONCLUSION: DTI, DKI and VBM may be used as a surveillance tool in detecting brain microstructural changes of NPC patients which correlates to latency and brain areas following RT. PMID: 33414057 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 4, 2021 Category: Cancer & Oncology Authors: Voon NS, Lau FN, Zakaria R, Md Rani SA, Ismail F, Manan HA, Yahya N Tags: Cancer Radiother Source Type: research

Correlation between changes in the number of peripheral blood lymphocytes and survival rate in patients with cervical cancer after radio-chemotherapy.
This study aimed to compare the absolute numbers of various types of lymphocytes in the peripheral blood before and after chemotherapy following radio-chemotherapy in patients with cervical cancer, so as to explore the correlation between the changes in the absolute numbers of peripheral various types of lymphocytes and the overall survival rate of patients. METHODS: Data of 205 patients with cervical cancer admitted to the hospital from June 2014 to August 2016 were retrospectively analyzed. These patients underwent concurrent radio-chemotherapy, followed by chemotherapy. The absolute numbers of peripheral blood lymp...
Source: Cancer Radiotherapie - January 4, 2021 Category: Cancer & Oncology Authors: Han X, Yang Q, Zhang J, Cao J Tags: Cancer Radiother Source Type: research

Glassy cell carcinoma of the uterine cervix: 20-year experience from a comprehensive cancer center.
CONCLUSION: Large cohort data are warranted to guide the optimal management of GCC. From this retrospective analysis, a multimodal approach yielded to good disease control in early stages tumors. Given the high-risk of distant failure, consideration should be given to adjuvant chemotherapy in locally advanced disease. PMID: 33408051 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 3, 2021 Category: Cancer & Oncology Authors: Boustani J, Achkar S, Bertaut A, Genestie C, Gouy S, Pautier P, Morice P, Haie-Meder C, Chargari C Tags: Cancer Radiother Source Type: research

[Diffusion prophylactic axillary irradiation in breast cancer - Literature review].
CONCLUSIONS: Incidental axillary dose seems insufficient to be therapeutic regardless of the irradiation technique. There are meaningful differences between intensity modulated radiation therapy and 3D-conformal radiotherapy. PMID: 33402287 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 2, 2021 Category: Cancer & Oncology Authors: Schmitt M, Pin Y, Pflumio C, Mathelin C, Pivot X, Noël G Tags: Cancer Radiother Source Type: research

[Telemedicine for prostate cancer during long-term radiotherapy follow-up: An opportunity for digital innovation in oncology].
CONCLUSION: This feasibility study with an aged cohort showed that telemedicine is a valuable option for long-term radiotherapy follow-up, even if therapeutic education and information will be necessary to supervise this novel approach. PMID: 33402288 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 2, 2021 Category: Cancer & Oncology Authors: Suc L, Daguenet E, Louati S, Gras M, Langrand-Escure J, Sotton S, Magné N Tags: Cancer Radiother Source Type: research

Dosimetric comparison of four high performance techniques for irradiation of breast cancer patients.
CONCLUSION: HT_FW_5 and VMAT plans allow a significant reduction of treatment duration and can be a good alternative to HT_FW_2.5 for specific populations. HT_FW_2.5 could be chosen for patients at higher risk of side effects. In addition, PT_PBS should be considered in the near future as it has been shown to have a major potential benefit to lower the risk of side effects with the same level of PTV coverage. PMID: 33402289 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 2, 2021 Category: Cancer & Oncology Authors: Bartolucci L, Adrien C, Goudjil F, Amessis M, El Amine W, Fourquet A, Mazal A, Kirova Y Tags: Cancer Radiother Source Type: research

Total body irradiation using helical tomotherapy: Set-up experience and in-vivo dosimetric evaluation.
CONCLUSION: The full methodology to set up TBI protocol, as well as dosimetric evaluation and pre-treatment QA, were presented. Our investigations reveal strong correspondence between planned and delivered doses shedding light on the dose reliability of OSLD for HT based TBI in-vivo dosimetry. PMID: 33402290 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 2, 2021 Category: Cancer & Oncology Authors: Cleuziou JP, Desgranges C, Henry I, Jaumot M, Chartier P, Sihanath R, Carré M, Bulabois CE, Cahn JY, Pasteris C, Balosso J, Gabelle-Flandin I, Verry C, Giraud JY Tags: Cancer Radiother Source Type: research

[Ductal carcinomas of the parotid gland].
CONCLUSION: Ductal carcinoma is a rare and aggressive tumor of the parotid gland. It can be primary or secondary. The treatment is based on surgery and radiotherapy. The prognosis is poor. PMID: 33402291 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 2, 2021 Category: Cancer & Oncology Authors: Mnejja M, Kallel S, Thabet W, Regaieg M, Kallel R, Boudawara T, Daoud J, Hammami B, Charfeddine I Tags: Cancer Radiother Source Type: research

Clinical and dosimetric impact of totally implantable venous access devices in radiotherapy of supra diaphragmatic Hodgkin Lymphoma.
Abstract PURPOSE: To evaluate attenuation of the totally implantable vascular access device (TIVAD) and assess its clinical and dosimetric impact on radiotherapy (RT) of lymphoma patients. MATERIALS AND METHODS: The first part of the study consisted of an in vitro approach by irradiating the TIVAD with different electron and photon energies. The attenuation data measured were compared with data calculated by our treatment planning system. All patients treated by radiotherapy for Hodgkin's lymphoma with their TIVAD in the target volume were then reviewed to assess the clinical outcome and dosimetric comparison...
Source: Cancer Radiotherapie - January 2, 2021 Category: Cancer & Oncology Authors: Laurans M, Kirov K, Costa E, Lefebvre D, Kirova YM Tags: Cancer Radiother Source Type: research

[A review of adaptive radiotherapy for bladder cancer].
CONCLUSION: ART is the technique of choice for bladder cancer RT. The "plan of the day" approach, individualized according to the A-POLO methodology, seems to be the most effective. The emergence of daily re-optimization, especially using MRI-Linac, is promising. The correlation between dosimetric benefits and clinical efficacy and safety results should be demonstrated into future trials. PMID: 33402293 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 2, 2021 Category: Cancer & Oncology Authors: Cabaillé M, Khalifa J, Tessier AM, Belhomme S, Créhange G, Sargos P Tags: Cancer Radiother Source Type: research

Radiosurgery and stereotactic irradiation of multiple and contiguous brain metastases: A practical proposal of dose prescription methods and a literature review.
CONCLUSIONS: The six dosimetric approaches here described can be used by physicians for multiple contiguous BM, depending on the clinical situation. These methods may be applied in clinical studies to better evaluate their usefulness in practice. PMID: 33390318 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 31, 2020 Category: Cancer & Oncology Authors: Di Rito A, Chaikh A, Troussier I, Darmon I, Thariat J Tags: Cancer Radiother Source Type: research