Evaluation of a software for automatic delineation of the mammary gland and organs at risk in patients treated for breast cancer in lateral position.
CONCLUSION: Workflow Box™ automatic contouring software, based on our new atlas provides reliable and clinically relevant organs at risk and breast contouring. The contours proposed by the software from the new atlas were better than those obtained with the previous atlas based on 95% isodoses obtained from old treatment plans. This software has therefore become more efficient, justifying its use in routine clinical practice for breast cancer contouring in patients treated in the lateral decubitus position. Investigations are currently underway to develop a fully automated process to ensure reliable, robust and opera...
Source: Cancer Radiotherapie - October 9, 2020 Category: Cancer & Oncology Authors: Msika R, Tkatchenko N, Robilliard M, Fourquet A, Kirova Y Tags: Cancer Radiother Source Type: research

[Erratum to "Stereotaxic radiotherapy of primary extracranial tumors" [Cancer Radiother. 24 (2020) DOI:10.1016/j.canrad.2020.06.020]].
[Erratum to "Stereotaxic radiotherapy of primary extracranial tumors" [Cancer Radiother. 24 (2020) DOI:10.1016/j.canrad.2020.06.020]]. Cancer Radiother. 2020 Sep 28;: Authors: Lerouge D, Latorzeff I, Mirabel X, Dohan A, Mordant P, Barry De Longchamps N, Giraud P PMID: 33004297 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 27, 2020 Category: Cancer & Oncology Authors: Lerouge D, Latorzeff I, Mirabel X, Dohan A, Mordant P, Barry De Longchamps N, Giraud P Tags: Cancer Radiother Source Type: research

Institut Curie guidelines on breast target volume delineation for patients treated in lateral position.
CONCLUSION: This atlas will be helpful for the volume definition in our daily practice of breast irradiation in lateral position and can open perspectives to develop also atlases for other alternative techniques as treatment in prone position. PMID: 32981844 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 23, 2020 Category: Cancer & Oncology Authors: Msika R, Fourquet A, Laki F, Porte B, Servois V, Kirova Y Tags: Cancer Radiother Source Type: research

[Postoperative radiotherapy after immediate breast reconstruction].
era S Abstract Immediate breast reconstruction versus delayed breast reconstruction improves quality of life of breast cancer patients undergoing total mastectomy without impacting oncologic outcomes. Two types of immediate reconstruction are possible, implant-based reconstruction or autologous reconstruction. These reconstructions interpose a tissue in the operating bed, which modifies target volume definition compared to a wall without reconstruction Post mastectomy radiotherapy increases the rate of postoperative complications for both surgical procedures. Recent guidelines were published about target volume de...
Source: Cancer Radiotherapie - August 30, 2020 Category: Cancer & Oncology Authors: Rogé M, Thureau S, Carrilho J, Thariat J, Rivera S Tags: Cancer Radiother Source Type: research

[Health Data Hub in France, use cases in oncology and radiation oncology].
Abstract Health data financed by the French national solidarity system constitute a common heritage. Such data should be exploited to optimize care while complying with ethics and fundamental rights of citizens. The creation of the Health Data Hub (HDH) was allowed by the 24 July 2019 Law on the organization and transformation of the French health system. Its objective is to enable authorized innovative project leaders to access non-nominative data via a state-of-the-art secure technological platform. It appears to be one of the strong points of the French Artificial Intelligence strategy. This structure is a publ...
Source: Cancer Radiotherapie - August 28, 2020 Category: Cancer & Oncology Authors: Combes S, Bacry E, Fontbonne C Tags: Cancer Radiother Source Type: research

Tomographie par émission de positons (TEP) pour la radiothérapie : technique et innovations.
This article will specifically review PET technology, its latest advances and the potential impact on radiotherapy, particularly head and neck cancers. PMID: 32861609 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 26, 2020 Category: Cancer & Oncology Authors: Decazes P, Hapdey S, Larnaudie A, Thariat J, Thureau S Tags: Cancer Radiother Source Type: research

[Health democracy: Patient partnership].
de la SFRO Abstract In 2019, the scientific committee of the French society of radiation oncology (SFRO) created an ethics committee. Its mission is to provide our professional community with food for thought on ethical issues, and to identify its specificities within the radiation oncology departments. For the 2020 annual conference, the commission looked into the evolution of the patient-carer relationship, and more particularly to the strong idea of patient partnership. Indeed, the writing of the White Book of Cancer gave voice to sick people and stressed the need for new devices, such as the Caregiving T...
Source: Cancer Radiotherapie - August 26, 2020 Category: Cancer & Oncology Authors: Haaser T, Constantinidès Y, Dejean C, Escande A, Le Tallec P, Lorchel F, Marty S, Thureau S, Huguet F, Lagrange JL, pour la Commission éthique de la SFRO Tags: Cancer Radiother Source Type: research

[Concurrent chemoradiotherapy for head neck cancers. Should organs at risk dose constraints be revisited  ?]
[Concurrent chemoradiotherapy for head neck cancers. Should organs at risk dose constraints be revisited ?] Cancer Radiother. 2020 Aug 26;: Authors: Lapeyre M, Biau J, Miroir J, Moreau J, Gleyzolle B, Brun L, Racadot S, Graff-Cailleaud P Abstract Concurrent chemoradiotherapy improves the outcome of locally advanced head and neck cancers and the current reference chemotherapy is cisplatin. These results are obtained at the cost of increased toxicities. To limit the risk of toxicity, organ at riskdose constraints have been established starting with 2D radiotherapy, then 3D radiotherapy and intensit...
Source: Cancer Radiotherapie - August 25, 2020 Category: Cancer & Oncology Authors: Lapeyre M, Biau J, Miroir J, Moreau J, Gleyzolle B, Brun L, Racadot S, Graff-Cailleaud P Tags: Cancer Radiother Source Type: research

Time of PTV is ending, robust optimization comes next.
rie T Abstract Continuous improvements have been made in the way to prescribe, record and report dose distributions since the therapeutic use of ionizing radiations. The international commission for radiation units and measurement (ICRU) has provided a common language for physicians and physicists to plan and evaluate their treatments. The PTV concept has been used for more than two decades but is becoming obsolete as the CTV-to-PTV margin creates a static dose cloud that does not properly recapitulate all planning vs. delivery uncertainties. The robust optimization concept has recently emerged to overcome the lim...
Source: Cancer Radiotherapie - August 25, 2020 Category: Cancer & Oncology Authors: Biston MC, Chiavassa S, Grégoire V, Thariat J, Lacornerie T Tags: Cancer Radiother Source Type: research

[Radiation-oncology horizon 2030: From microbiota to plasma laser].
evy A Abstract Advances in physical, technological and biological fields have made radiation oncology a discipline in continual evolution. New current research areas could be implemented in the clinic in the near future. In this review in the form of several interviews, various promising themes for our specialty are described such as the gut microbiota, tumor organoids (or avatar), artificial intelligence, connected therapies, nanotechnologies and plasma laser. The individual prediction of the best therapeutic index combined with the integration of new technologies will ideally allow highly personalized treatment ...
Source: Cancer Radiotherapie - August 25, 2020 Category: Cancer & Oncology Authors: Beaudelot C, Bayart E, Thariat J, Bourgier C, Denis F, Hatt M, Pasquier D, Verry C, Deutsch É, Levy A Tags: Cancer Radiother Source Type: research

Metallic implants and CT artefacts in the CTV area: Where are we in 2020?
Abstract Radiation therapy (RT) is one of the main modalities of cancer treatment worldwide with computed tomography (CT), as the most commonly used imaging method for treatment planning system (TPS). Image reconstruction errors may greatly affect all the radiation therapy planning process, such as target delineation, dose calculation and delivery, particularly with particle therapy. Metallic implants, such as hip and spinal implants, and dental filling significantly deteriorate image quality. These hardware structures are often very complex in geometry leading to geometric complex artefacts in the clinical target...
Source: Cancer Radiotherapie - August 24, 2020 Category: Cancer & Oncology Authors: Rousselle A, Amelot A, Thariat J, Jacob J, Mercy G, De Marzi L, Feuvret L Tags: Cancer Radiother Source Type: research

PET and MRI guided adaptive radiotherapy: Rational, feasibility and benefit.
Abstract Adaptive radiotherapy (ART) corresponds to various replanning strategies aiming to correct for anatomical variations occurring during the course of radiotherapy. The goal of the article was to report the rational, feasibility and benefit of using PET and/or MRI to guide this ART strategy in various tumor localizations. The anatomical modifications defined by scanner taking into account tumour mobility and volume variation are not always sufficient to optimise treatment. The contribution of functional imaging by PET or the precision of soft tissue by MRI makes it possible to consider optimized ART. Today, ...
Source: Cancer Radiotherapie - August 24, 2020 Category: Cancer & Oncology Authors: Thureau S, Briens A, Decazes P, Castelli J, Barateau A, Garcia R, Thariat J, de Crevoisier R Tags: Cancer Radiother Source Type: research

Radiotherapy of non-tumoral refractory neurological pathologies.
ier D Abstract Intracranial radiotherapy has been improved, primarily because of the development of stereotactic approaches. While intracranial stereotactic body radiotherapy is mainly indicated for treatment of benign or malignant tumors, this procedure is also effective in the management of other neurological pathologies; it is delivered using GammaKnife® and linear accelerators. Thus, brain arteriovenous malformations in patients who are likely to experience permanent neurological sequelae can be managed by single session intracranial stereotactic body radiotherapy, or radiosurgery, in specific situations, ...
Source: Cancer Radiotherapie - August 24, 2020 Category: Cancer & Oncology Authors: Jacob J, Reyns N, Valéry CA, Feuvret L, Simon JM, Mazeron JJ, Jenny C, Cuttat M, Maingon P, Pasquier D Tags: Cancer Radiother Source Type: research

Use of radiomics in the radiation oncology setting: Where do we stand and what do we need?
Abstract Radiomics is a field that has been growing rapidly for the past ten years in medical imaging and more particularly in oncology where the primary objective is to contribute to personalised and predictive medicine. This short review aimed at providing some insights regarding the potential value of radiomics for cancer patients treated with radiotherapy. Radiomics may contribute to each stage of the patients' management: diagnosis, planning, treatment monitoring and post-treatment follow-up (toxicity and response). However, its applicability in clinical routine is currently hindered by several factors, inclu...
Source: Cancer Radiotherapie - August 24, 2020 Category: Cancer & Oncology Authors: Schick U, Lucia F, Bourbonne V, Dissaux G, Pradier O, Jaouen V, Tixier F, Visvikis D, Hatt M Tags: Cancer Radiother Source Type: research

[Treatment of radiation-induced late effects: What's new?]
Abstract Mechanisms of late radio-induced lesions are the result of multiple and complex phenomena, with many entangled cellular and tissue factors. The biological continuum between acute and late radio-induced effects will be described, with firstly a break in homeostasis that leads to cellular redistributions. New insights into late toxicity will finally be addressed. Individual radiosensitivity is a primary factor for the development of late toxicity, and clinicians urgently need predictive tests to offer truly personalized radiation therapy. An update will be made on the various functional and genetic tests cu...
Source: Cancer Radiotherapie - August 23, 2020 Category: Cancer & Oncology Authors: Chargari C, Supiot S, Hennequin C, Chapel A, Simon JM Tags: Cancer Radiother Source Type: research

[Treatment of primary disease for synchronous metastatic prostate cancer].
This article states the biological bases, the main published and future published studies aimed to embed this strategy to optimize therapeutic management. PMID: 32855028 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 23, 2020 Category: Cancer & Oncology Authors: Laville A, Coutte A, Blanchard P, Sun R, Deutsch E, Latorzeff I Tags: Cancer Radiother Source Type: research

[Retrospective study on the intensification of hypofractionated radiotherapy: The organizational change].
cute; Abstract PURPOSE: External radiotherapy process is a chain of steps in which each of them is carried out only if the previous one has been completed. The development of hypofractionation practices in recent years tends to increase the workload of the stages of preparation for irradiation and to decrease the number of fractions per patient. The purpose of this retrospective study is to analyze the evolution of these practices in a single centre and to assess the organizational issues involved. MATERIAL AND METHODS: All radiation therapy records management data were extracted from the Radiation Therapy In...
Source: Cancer Radiotherapie - August 20, 2020 Category: Cancer & Oncology Authors: Corbin S, Brusadin G, Rivera S, Bossi A, Deutsch É Tags: Cancer Radiother Source Type: research

[Clinical trials that have changed our practices 2010-2020].
CONCLUSION: Depending on the pathologies, the questions raised over the past 10 years remain fundamental questions such as the place of neoadjuvant treatment, the place of hypofractionation or the type of chemotherapy concomitant with radiotherapy. PMID: 32839104 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 20, 2020 Category: Cancer & Oncology Authors: Mège A, Biau J, Meyer E, Allouache N, Guigo M, Servagi Vernat S Tags: Cancer Radiother Source Type: research

[Adjuvant and neoadjuvant radiotherapy in breast cancer: A literaure review and update on the state of the evidence in 2020].
Abstract Radiation therapy has benefited from many developments over the past 20 years. These developments are mainly linked to the technology, imaging and informatics evolutions which allow better targets definitions, ensure better organs-at-risk sparing and excellent reproducibility of treatments, with a perfect control of patient positioning. In breast cancer radiotherapy, the evolution was marked by the possibility of reducing the duration of treatments from 6-7 to 3-4 weeks by using hypofractionated regimens, or by further reducing the irradiation to one week when treatment is solely focalised ...
Source: Cancer Radiotherapie - August 20, 2020 Category: Cancer & Oncology Authors: Belkacemi Y, Debbi K, Loganadane G, Ghith S, Hadhri A, Hassani W, Cherif MA, Coraggio G, To NH, Colson-Durand L, Grellier N Tags: Cancer Radiother Source Type: research

Radio-induced cardiotoxicity: From physiopathology and risk factors to adaptation of radiotherapy treatment planning and recommended cardiac follow-up.
Abstract Cancer and cardiovascular disease (CVD) are the leading cause of mortality worldwide, and breast cancer (BC) the most common malignancy affecting women worldwide. Radiotherapy is an important component of BC treatment and participates in CVD occurrence. It seems, therefore, crucial to gather both radiation oncology and cardiology medical fields to improve the follow-up quality of our BC patients. This review aims at updating our knowledge regarding cardiotoxicities risk factors, and consequently, doses constraints in case of 3D-conformal and IMRT treatment planning. Then we will develop how to reduce card...
Source: Cancer Radiotherapie - August 19, 2020 Category: Cancer & Oncology Authors: Kirova Y, Tallet A, Aznar MC, Loap P, Bouali A, Bourgier C Tags: Cancer Radiother Source Type: research

[Stereotaxic radiotherapy of primary extracranial tumors].
Abstract Stereotactic radiotherapy is a fundamental change from the conventional fractionated radiotherapy and represents a new therapeutic indication. Stereotactic radiotherapy is now a standard of care for inoperable patients or patients who refuse surgery. The results are encouraging with local control and survival rates very high in selected populations. The rate of late toxicity remains acceptable. Good tolerability makes it appropriate even for elderly and frail patients. In these fragile patients or in certain specific clinical situations, different surgical, radiotherapy or interventional radiology attitud...
Source: Cancer Radiotherapie - August 19, 2020 Category: Cancer & Oncology Authors: Giraud P, Lerouge D, Latorzeff I, Mirabel X, Dohan A, Mordant P, Barry de Longchamps N Tags: Cancer Radiother Source Type: research

Radiotherapy for primary tumor in lung cancer with synchronous metastases: Overview from the past and proposal for the future.
Abstract The management of metastatic lung cancers, either of the small-cell (SCLC) or the non-small cell (NSCLC) subtype, largely based on systemic treatments so far, has been the subject of breakthrough advances over the past few years, with notably the wide use of immunotherapy changing the landscape of these harmful prognosis diseases. In parallel with this major progress, the increasing use of radiotherapy (RT) for the treatment of the primary thoracic lesion±the distant lesions, may contribute to improving the condition of these metastatic patients, both in terms of progression-free survival (PFS) and...
Source: Cancer Radiotherapie - August 18, 2020 Category: Cancer & Oncology Authors: Laurent PA, Martin E, Thariat J, Doyen J Tags: Cancer Radiother Source Type: research

[Place and modalities of postoperative radiotherapy in the management of cerebral metastases].
Abstract Metastases are the most common brain tumors. After surgery, stereotactic radiotherapy (SRT) of the resection cavity is the standard of care. Data from two randomized trials indicate that SRT to the surgical bed is an effective treatment in reducing local failure as compared with observation, while reducing the risk of cognitive deterioration and maintaining quality of life as compared with whole brain radiation therapy. Local control appears higher after hypofractionated SRT compared to single-fraction SRT. Several questions such as target volumes, the optimal regimen in particular for large tumor bed, st...
Source: Cancer Radiotherapie - August 18, 2020 Category: Cancer & Oncology Authors: Pasquier D, Mouttet Audouard R, Martinage G, Lacornerie T, Mirabel X, Lartigau E Tags: Cancer Radiother Source Type: research

[Seeking colleagues' advice when facing complex clinical situations].
Abstract Seeking a second medical advice as a medical practitioner is a frequent situation that should be facilitated to best suit patients' expectations, while maintaining medical confidentiality. The patient and his relatives need to be involved with diagnostic and therapeutic procedures. The radiation oncologist should accept and help a patient who seeks a second advice, and patients will always appreciate when the physician helps them to seek such an advice. Examples that each practitioner should know include tertiary centers tumor boards, centers with access to innovation or clinical research, or with special...
Source: Cancer Radiotherapie - August 18, 2020 Category: Cancer & Oncology Authors: Blanchard P, Peiffert D, Truc G Tags: Cancer Radiother Source Type: research

Role of radiation therapy in brain metastases management.
t A Abstract The challenge of the management of brain metastases has not finished yet. Although new diagnosis-specific prognostic assessment classifications and guidelines for patients with brain metastases help to guide treatment more appropriately, and even if the development of modern technologies in imaging and radiation treatment, as well as improved new systemic therapies, allow to reduce cognitive side effects and make retreatment or multiple and combined treatment possible, several questions remain unanswered. However, tailoring the treatment to the patient and his expectations is still essential; in other...
Source: Cancer Radiotherapie - August 18, 2020 Category: Cancer & Oncology Authors: Dhermain F, Noël G, Antoni D, Tallet A Tags: Cancer Radiother Source Type: research

[Uncertainties in the current concept of radiotherapy planning target volume].
This article attempts to discuss these various uncertainties and tries to demonstrate that a redefinition of the concept of planning target volume toward its personalization for each patient and the robustness notion are likely an improvement basis to take into account the radiotherapy uncertainties. PMID: 32828670 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 18, 2020 Category: Cancer & Oncology Authors: Noël G, Thariat J, Antoni D Tags: Cancer Radiother Source Type: research

[Treatment of primary disease with irradiation in case of de novo metastatic breast cancer].
This article provides an update on the role of irradiation of the primary tumour in breast cancer with synchronous metastases, and discusses its interest through published or ongoing trials. PMID: 32814669 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 15, 2020 Category: Cancer & Oncology Authors: Ghannam Y, Bourgier C, Legouté F, Gonzalez-Moya A, Lizée T, Trémolières P, Hennequin C Tags: Cancer Radiother Source Type: research

[Gastric and pancreatic cancers: Will neoadjuvant (chemo)radiotherapy replace adjuvant chemoradiotherapy?]
eacute;ro L Abstract For many years, adjuvant chemoradiotherapy remained essential in the therapeutic management of gastric and pancreatic adenocarcinomas. For these tumours, surgical excision, the only hope of offering the patient prolonged survival, is only possible in 20% of cases. The median survival of operated patients is only 12 to 20 months due to the frequency of locoregional and/or metastatic recurrences. For stomach cancers, adjuvant chemoradiotherapy is justified by the results of the phase III trial Intergroup 0116 published by MacDonald et al. The gain in survival was at the cost of significant toxic...
Source: Cancer Radiotherapie - August 15, 2020 Category: Cancer & Oncology Authors: Huguet F, Rivin Del Campo E, Labidi M, Ménard J, Sergent G, Durand B, Quéro L Tags: Cancer Radiother Source Type: research

[How a self-managed team can improve cohesion and communication during the patient's journey in a radiotherapy department: Experience of centre Jean-Bernard (Le Mans, France)].
uis O Abstract Efficient communication between professionals is of upmost importance in improving treatment safety in a radiotherapy department, and is also necessary to enhance the quality of work life. Taking as example the organizations in industry, a self-managed team centred on patients with head and neck cancers treated with radiation has been implemented in 2018 in centre Jean-Bernard (Le Mans, France). After over a year's experience, a real benefice has been found and validates the plan to extend this model to other departments. PMID: 32807684 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 13, 2020 Category: Cancer & Oncology Authors: Pasquier C, Gaudias C, Lepouzé O, Touchard C, Bombard S, Lafond C, Dupuis O Tags: Cancer Radiother Source Type: research

Pre- or postoperative radiotherapy for soft tissue sarcomas.
, Thariat J Abstract Sarcomas are rare tumours arising from mesenchymal tissue. A multimodal management in an expert centre combining surgery and radiotherapy is the current standard of care for localized soft-tissue sarcomas of the extremities, to enable limb-sparing strategies. The delivery of pre- radiotherapy or postoperative radiotherapy offers similar local control and survival rates but the toxicity profile is quite different: preoperative radiotherapy increases the risk of wound complications and postoperative radiotherapy affects long-term functional outcomes. While postoperative radiotherapy has long bee...
Source: Cancer Radiotherapie - August 13, 2020 Category: Cancer & Oncology Authors: Llacer-Moscardo C, Terlizzi M, Bonvalot S, Le Loarer F, Carrère S, Tetrau R, D'ascoli A, Lerouge D, Le Péchoux C, Thariat J Tags: Cancer Radiother Source Type: research

[The evolving career profile of radiation therapists].
Abstract Over the last few years, the radiation therapist profession has undergone major developments. In radiotherapy, the teams, and their organization as well as the techniques have changed, however always with the goal of improving treatment quality for patients. Throughout interviews, this article offers to show three missions that have been assigned to French radiation therapists, such as the initial consultation, the role of the radiation therapist with the linear accelerator with onboard MRI, and paramedical research. The contribution of new technologies, the modification of the types of participants on th...
Source: Cancer Radiotherapie - August 13, 2020 Category: Cancer & Oncology Authors: Boisbouvier S, Tachin C, Lecoeur A, Le Tallec P Tags: Cancer Radiother Source Type: research

[French Health Authority certification visit in a radiotherapy department].
Abstract The French Higher Health Authority's (Haute Autorité de santé [HAS]) certification process is an important issue for a health care facility and in particular for a radiotherapy department. It is based on a quality-risk management methodology driven by the commitment and involvement of professionals. The radiotherapy department of the university hospital in Brest (France) has been engaged for many years in a demanding quality-risk management policy implementation, subjected to regular inspections by the French Nuclear Safety Authority (Autorité de sûreté nucléaire [...
Source: Cancer Radiotherapie - August 9, 2020 Category: Cancer & Oncology Authors: Ponsard N, Heddadi L, Pradier O Tags: Cancer Radiother Source Type: research

[Refractory ventricular tachycardia: Is there a role for radiotherapy?]
This article describes the use of stereotactic body radiotherapy in refractory VT, the rationale of the technique, its implementation, preliminary results and potential acute and long-term consequences. PMID: 32792297 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 9, 2020 Category: Cancer & Oncology Authors: Jumeau R, Pruvot É, Thariat J, Latorzeff I, Milliez PU, Champ-Rigot L, De Crevoisier R, Ferchaud V Tags: Cancer Radiother Source Type: research

[Impact of reconstructive or minimal invasive surgery on the assessment of current definitions of postoperative clinical target volume for head and neck cancers].
, Thariat J Abstract Advances in the reconstructive surgery and minimally invasive endonasal endoscopic surgery of head and neck is poorly evaluated in terms of their impact on radiotherapy planning and outcomes. These surgical advances have resulted in reduced morbidity with equivalent or better tumor control. In the absence of a recommendation on how to delineate target volumes in patients with flaps or to consider margins after endoscopic endonasal surgery, radiotherapy practices are inevitably heterogeneous. Efforts are needed to increase the therapeutic index of postoperative radiotherapy in these situations....
Source: Cancer Radiotherapie - August 7, 2020 Category: Cancer & Oncology Authors: Racadot S, Vérillaud B, Serre AA, Le Guevelou J, Guzene L, Laude C, Grégoire V, Deneuve S, Larnaudie A, Lasne-Cardon A, Thariat J Tags: Cancer Radiother Source Type: research

[What is the place of surgery in the management of brain metastases in 2020?]
Proust F Abstract Brain metastases are the most common intracranial tumors and are associated with a dismal prognosis. The management of patients with brain metastases has become more important because of the increased incidence of these tumours, the better treatment of the systemic disease and the improvement of surgical techniques. The treatment requires multidisciplinary approaches and become complex because of new emerging systemic therapy and advancements in neurosurgery and radiation oncology. The surgical treatment has an indispensable role to obtain a tissue diagnosis, in relieving intracranial effect mas...
Source: Cancer Radiotherapie - August 5, 2020 Category: Cancer & Oncology Authors: Cebula H, Todeschi J, Le Fèvre C, Antoni D, Ollivier I, Chibbaro S, Noël G, Proust F Tags: Cancer Radiother Source Type: research

[Do dose constraints to organs at risk need to be adapted when irradiation is combined with drug therapy?]
Abstract Therapeutic strategies combining irradiation and drugs including chemotherapy, hormonotherapy, but also more recently targeted therapy and immunotherapy are routinely used for cancer treatment. Nevertheless, combined treatments usually lead to a rise in toxicity. In order to increase the therapeutic ratio in favour of a multimodality treatment, adapting dose constraints to organs at risk may be the key to lower the risk of toxicity. A review of the literature was conducted, focusing on the toxicity in dose-limiting organs at risk when radiation therapy is associated with drugs. Four situations were differ...
Source: Cancer Radiotherapie - August 5, 2020 Category: Cancer & Oncology Authors: Jouglar E, Doyen J, Supiot S Tags: Cancer Radiother Source Type: research

Exploiting the full potential of proton therapy: An update on the specifics and innovations towards spatial or temporal optimisation of dose delivery.
Abstract Prescription and delivery of protons are somewhat different compared to photons and may influence outcomes (tumour control and toxicity). These differences should be taken into account to fully exploit the clinical potential of proton therapy. Innovations in proton therapy treatment are also required to widen the therapeutic window and determine appropriate populations of patients that would benefit from new treatments. Therefore, strategies are now being developed to reduce side effects to critical normal tissues using alternative treatment configurations and new spatial or temporal-driven optimisation a...
Source: Cancer Radiotherapie - July 31, 2020 Category: Cancer & Oncology Authors: De Marzi L, Patriarca A, Scher N, Thariat J, Vidal M Tags: Cancer Radiother Source Type: research

[New concepts of medical consultation in oncology].
Abstract New concepts of medical consultations are currently disrupting the practice of medicine. The use of standardized questionnaires, or patient-reported outcome (PRO and ePRO) has already significantly changed the relationship between the physician and the patient. Telemedicine, or even automatic conversational agents, such as chatbots, are also providing more convenient access to care and medical information for many patients. These tools have a major impact in oncology, precisely because of the rising chronicity of the diseases the radiation oncologists treat. In this article, we provide a detailed analysis...
Source: Cancer Radiotherapie - July 31, 2020 Category: Cancer & Oncology Authors: Bibault JE, Denis F, Guihard S, Clavier JB, Durdux C, Giraud P, Kreps S, Maaradji S, Dautruche A, Fabiano E, Feutren T, Thariat J Tags: Cancer Radiother Source Type: research

[Choice optimisation of radiation therapy technique for central neurocytomas from literature data].
l G Abstract Neurocytomas represent 0,25 to 0,5 of brain tumours. These tumours have neuronal differentiation. It's a young adult disease. The main treatment is neurosurgery. The place of other therapies is still unclear, noticeably with regards to radiotherapy. This review aim is to determine the place and the modalities of radiotherapy in the management of neurocytomas. A literature search using PubMed allowed to select the most relevant studies. Finally, 22 studies were selected according to pre-established criteria to answer the problem. All studies were retrospective studies except one. The analysis conclusio...
Source: Cancer Radiotherapie - July 31, 2020 Category: Cancer & Oncology Authors: Virbel G, Cebula H, Coca A, Lhermitte B, Bauchet L, Noël G Tags: Cancer Radiother Source Type: research

[Can stereotactic body radiotherapy replace brachytherapy for locally advanced cervical cancer? French society for radiation oncology statement].
vi JM Abstract Brachytherapy is part of the treatment of locally advanced cervical cancers, accounting for about half of the total delivered dose. The benefit of dose escalation is the most important in advanced cases or if the tumor has responded poorly. The use of interstitial implantations makes it possible to reach doses of the order of 85 to 90Gy (including external beam radiotherapy contribution) in most patients, through image-guided approaches. Brachytherapy delivery is one of the quality criteria for patient care. To date, no data allow us to consider as an alternative the use of external boost through in...
Source: Cancer Radiotherapie - July 31, 2020 Category: Cancer & Oncology Authors: Chargari C, Renard S, Espenel S, Escande A, Buchheit I, Ducassou A, Peiffert D, Hannoun-Lévi JM Tags: Cancer Radiother Source Type: research

Proton therapy and the European Particle Therapy Network: The past, present and future.
Abstract Proton therapy is delivered to selected cancer patients presenting with rare tumours, for which a dose escalation paradigm and/or a reduced dose-bath to the organs at risk is pursued. It is a costly treatment with an additional cost factor of 2-3 when compared to photon radiotherapy. Notwithstanding the 180'000 patients treated with protons, scars robust clinical evidence is available to justify the administration of this treatment modality. The European Particle Therapy Network (EPTN) was created in 2015 to answer the critical European needs for cooperation among protons and carbon ions centres in the fr...
Source: Cancer Radiotherapie - July 31, 2020 Category: Cancer & Oncology Authors: Weber DC, Langendijk JA, Grau C, Thariat J Tags: Cancer Radiother Source Type: research

Radiation therapy on primary tumour of synchronous metastatic head and neck squamous cell carcinomas.
CONCLUSION: Because locoregional disease is a major cause of disease failure in patients with synchronous metastatic head and neck squamous cell carcinomas, aggressive locoregional radiation therapy to the primary tumour may be discussed in the initial management of the disease where systemic therapy alone may not induce sufficient primary tumour reduction. With recent technological advances in radiotherapy, the delivery of radiotherapy is safe and feasible even in metastatic setting. Clinical trials assessing radiotherapy use for metastatic head and neck squamous cell carcinomas are warranted. PMID: 32753240 [PubMed ...
Source: Cancer Radiotherapie - July 31, 2020 Category: Cancer & Oncology Authors: Tang É, Nguyen TV, Clatot F, Rambeau A, Johnson A, Sun XS, Tao Y, Thariat J Tags: Cancer Radiother Source Type: research

Radioresistant tumours: From identification to targeting.
iat J Abstract From surviving fraction to tumour curability, definitions of tumour radioresistance may vary depending on the view angle. Yet, mechanisms of radioresistance have been identified and involve tumour-specific oncogenic signalling pathways, tumour metabolism and proliferation, tumour microenvironment/hypoxia, genomics. Correlations between tumour biology (histology) and imaging allow theragnostic approaches that use non-invasive biological imaging using tracer functionalization of tumour pathway biomarkers, imaging of hypoxia, etc. Modelling dose prescription function based on their tumour radio-resista...
Source: Cancer Radiotherapie - July 31, 2020 Category: Cancer & Oncology Authors: Cohen-Jonathan-Moyal É, Vendrely V, Motte L, Balosso J, Thariat J Tags: Cancer Radiother Source Type: research

Correlation between fluorodeoxyglucose hotspots on preradiotherapy PET/CT and areas of cancer local relapse: Systematic review of literature.
Schick U Abstract The aim of the present paper is to systematically review all available literature on preradiotherapy high uptake areas (hotspots) as a potential target for dose escalation in different tumour sites, and to understand the potential role and limitations of fluorodeoxyglucose (FDG)-positron-emission tomography (PET)/computed tomography (CT) in this context. An electronic database (Medline) search was conducted to identify articles reporting on a correlation between high tracer uptake on pretreatment PET and preferential sites of local recurrence after radiotherapy. Search was limited to English lan...
Source: Cancer Radiotherapie - June 29, 2020 Category: Cancer & Oncology Authors: Abgral R, Bourhis D, Calais J, Lucia F, Leclère JC, Salaün PY, Vera P, Schick U Tags: Cancer Radiother Source Type: research

[Anatomical and functional imaging for radiotherapy planning].
aud P PMID: 32620458 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 29, 2020 Category: Cancer & Oncology Authors: Fournier L, Véra P, Giraud P Tags: Cancer Radiother Source Type: research

Prostate imaging: Contribution of PET PSMA and MRI.
This article presents the contribution of the latest advances in these two imaging techniques of prostate cancer and their future developments. PMID: 32620459 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 29, 2020 Category: Cancer & Oncology Authors: Abecassis JP, Ghazzar N, Peyromaure M, Giraud P Tags: Cancer Radiother Source Type: research

[Brachytherapy in France in 2020: State of the art and perspectives from the Groupe curieth érapie de la SFRO].
[Brachytherapy in France in 2020: State of the art and perspectives from the Groupe curiethérapie de la SFRO]. Cancer Radiother. 2020 Jun 20;: Authors: Hannoun-Lévi JM, Chand MÈ, Blanchard P, Chargari C, Escande A, Pierrat N, Pommier P, Peiffert D Abstract Because of its principle and its high proof level clinical results, brachytherapy represents a specific irradiation technique for the treatment of primary tumors as well as some local relapses in pre-irradiated area. After a glory period between the 80's and 90's, brachytherapy has progressively lost its attractiveness. In order...
Source: Cancer Radiotherapie - June 19, 2020 Category: Cancer & Oncology Authors: Hannoun-Lévi JM, Chand MÈ, Blanchard P, Chargari C, Escande A, Pierrat N, Pommier P, Peiffert D Tags: Cancer Radiother Source Type: research

Hyaluronic acid spacer in focal prostate reirradiation: A single centre experience.
CONCLUSION: Reirradiation after local recurrence following initial definitive radiotherapy together with hyaluronic acid spacer use seems to be effective and safe. PMID: 32565071 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 17, 2020 Category: Cancer & Oncology Authors: Ozyigit G, Hurmuz P, Akinci D, Esen SCB, Yilmaz MT, Akdogan B, Akyol FH Tags: Cancer Radiother Source Type: research

Radiological assessment after stereotactic body radiation of lung tumours.
Abstract The increasing use of stereotactic body radiation therapy for lung tumours comes along with new post-therapeutic imaging findings that should be known by physicians involved in patient follow-up. Radiation-induced lung injury is much more frequent than after conventional radiation therapy, it can also be delayed and has a different radiological presentation. Radiation-induced lung injury after stereotactic body radiation therapy involves the lung parenchyma surrounding the target tumour and appears as a dynamic process continuing for years after completion of the treatment. Thus, the radiological pattern ...
Source: Cancer Radiotherapie - June 9, 2020 Category: Cancer & Oncology Authors: Chassagnon G, Martini K, Giraud P, Revel MP Tags: Cancer Radiother Source Type: research

Diagnostic performance of imaging techniques for detecting of local recurrence after prostate brachytherapy.
CONCLUSION: Both MRI and fluorocholine PET/CT permit to highlight local recurrence sites after prostate brachytherapy. Confirmation biopsies are, however, necessary since this accuracy is insufficient. PMID: 32532578 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 8, 2020 Category: Cancer & Oncology Authors: Karahissarlian V, Sargos P, Blais E, Cazeau AL, Fontes F, Petitpierre F, Rigou G, De Vaugelade C, Mariey A, Hindié E, Thomas L Tags: Cancer Radiother Source Type: research