[Medical prevention and treatment of radiation-induced urological and nephrological complications].
né N Abstract Abdominal and pelvic irradiations play a major place in the management of patients with cancer and present a risk of acute and late side effects. Radiation-induced lesions can affect kidney or urological structures. These side effects can have an impact in the quality of life of patients. The aim of this article is to describe the physiopathology, the symptomatology, and the principles of management of radiation-induced nephropathy, uretheritis, cystitis, and urethritis. PMID: 30898418 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 18, 2019 Category: Cancer & Oncology Authors: Rehailia-Blanchard A, He MY, Rancoule C, Guillaume É, Guy JB, Vial N, Nivet A, Orliac H, Chargari C, Magné N Tags: Cancer Radiother Source Type: research

Construction and clinical evaluation of a new customized bite block used in radiotherapy of head and neck cancer.
CONCLUSION: A customized bite block is easy-made and worthy of clinical use. PMID: 30898419 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 18, 2019 Category: Cancer & Oncology Authors: Feng Z, Wang P, Gong L, Xu L, Zhang J, Zheng J, Zhang D, Tian T, Wang P Tags: Cancer Radiother Source Type: research

Dose fall-off patterns with volumetric modulated arc therapy and three-dimensional conformal radiotherapy including the "organ at risk" effect. Experience of linear accelerator-based frameless radiosurgery from a single institution.
CONCLUSION: Our study presents the dose fall-off patterns in context of frameless stereotactic radiation therapy. We have presented the dose fall-off data in the framework of three-dimensional conformal radiotherapy and volumetric modulated arc therapy in brain lesions. PMID: 30797691 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - February 20, 2019 Category: Cancer & Oncology Authors: Munshi A, Sarkar B, Roy S, Ganesh T, Mohanti BK Tags: Cancer Radiother Source Type: research

Anti-PD-1 immunotherapy in combination with sequential involved-site radiotherapy in heavily pretreated refractory Hodgkin lymphoma.
ice P Abstract The purpose of this study was to assess efficacy and tolerance of anti-programmed death (PD)-1 immunotherapy in combination with sequential involved-site radiotherapy in heavily pretreated refractory Hodgkin lymphoma. In this case series, we reported the outcome of four heavily pretreated patients with refractory Hodgkin lymphoma treated by anti-PD-1 immunotherapy and involved site radiation therapy. After a median follow-up of 13-month, all patients were alive with complete metabolic response. After radiotherapy, all four patients experienced lung toxicity, which was resolved after antibiotherapy w...
Source: Cancer Radiotherapie - February 4, 2019 Category: Cancer & Oncology Authors: Quéro L, Gilardin L, Fumagalli I, Martin V, Guillerm S, Bauduceau O, Kirova YM, Hennequin C, Brice P Tags: Cancer Radiother Source Type: research

Multidisciplinary treatment approach for primary thyroid spindle cell sarcoma: A case report.
Abstract A 25-year-old female with high-grade spindle cell sarcoma of the thyroid persistent after thyroidectomy performed at another hospital was referred to our institute. Chemotherapy followed by surgery with intraoperative radiotherapy and postoperative intensity-modulated radiotherapy were planned within the sarcoma board. Chemotherapy was discontinued after two cycles because of local disease progression and surgery with intraoperative radiotherapy, was anticipated. The treatment was completed with postoperative radiotherapy. After 36 months off-therapy, the patient was free of disease without significant la...
Source: Cancer Radiotherapie - January 11, 2019 Category: Cancer & Oncology Authors: Navarria F, Gigante M, Mascarin M, Italia F, Barresi L, Barzan L, Bertola G, Buonadonna A, Canzonieri V, De Paoli A Tags: Cancer Radiother Source Type: research

Harmonization of practices between radiotherapy centres in the Nord and Pas-de-Calais regions (France): A three-year evaluation.
CONCLUSION: This work makes it possible to harmonize the delineation practices around validated standards. An extension to the entire Hauts-de-France region is planned. PMID: 30639377 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 10, 2019 Category: Cancer & Oncology Authors: Pasquier D, Darloy F, Dewas S, Gras L, Maillard S, Rhliouch H, Tokarski M, Wagner JP, Degrendel-Courtecuisse AC, Dufour C, Fares M, Gilbeau L, Olszyk O, Castelain B, Lartigau É Tags: Cancer Radiother Source Type: research

Isomorphic and isotopic responses after radiation therapy.
PMID: 30639378 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 10, 2019 Category: Cancer & Oncology Authors: De Vita V, Ruocco E Tags: Cancer Radiother Source Type: research

[Chemoradiation for oesophageal cancer: A critical review of the literature].
Troussier I Abstract Locally advanced oesophageal cancer treatment requires a multidisciplinary approach with the combination of chemotherapy and radiotherapy for preoperative and definitive strategy. Preoperative chemoradiation improves the locoregional control and overall survival after surgery for locally advanced oesophageal cancer. Definitive chemoradiation can also be proposed for non-resectable tumours or medically inoperable patients. Besides, definitive chemoradiation is considered as an alternative option to surgery for locally advanced squamous cell carcinomas. Chemotherapy regimen associated to radioth...
Source: Cancer Radiotherapie - January 10, 2019 Category: Cancer & Oncology Authors: Blais E, Vendrely V, Sargos P, Créhange G, Huguet F, Maingon P, Simon JM, Bourdais R, Ozsahin M, Bourhis J, Clément-Colmou K, Belghith B, Proudhom Briois MA, Gilliot O, Dujols JP, Peyras A, Dupin C, Riet FG, Canova CH, Huertas A, Troussier I Tags: Cancer Radiother Source Type: research

[Locoregional control and patterns of locoregional failure in women with breast cancer treated by highly conformal electron beam irradiation].
CONCLUSION: In presented series, the local recurrence resulted mostly from of biologic radio resistance whereas regional recurrences were caused by geographical miss. A number of nodal recurrences could occur outside the target volumes defined by ESTRO and RTOG. PMID: 30595340 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 27, 2018 Category: Cancer & Oncology Authors: Loganadane G, Xi Z, Fournier-Bidoz N, Xu HP, Grellier Adedjouma N, Bazire L, Fourquet A, Kirova YM Tags: Cancer Radiother Source Type: research

[Thyroid function after hypofractionated adjuvant radiotherapy for localized breast cancer].
CONCLUSION: Although hypofractionation theoretically exposes the thyroid gland to late radiotherapy complications, radiation-induced dysthyroidism remains a complication underestimated by clinicians, and in the absence of prevention and treatment guidelines, it is necessary to delineate systematically the thyroid gland, to try to minimize as much as possible the doses received by this organ, and to monitor the thyroid function by periodic serum assays. PMID: 30595341 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 27, 2018 Category: Cancer & Oncology Authors: Dahbi Z, Sbai A, Mezouar L Tags: Cancer Radiother Source Type: research

[Contribution and limits of intensity-modulated reirradiation of nasopharyngeal carcinomas].
CONCLUSION: Intensity-modulation is an attractive technique for reirradiation of the nasopharynx. It allows a better conformity of the dose to the target and a reduction of the doses on the already irradiated critical organs. This offers good control of the disease with fewer severe late toxicities. PMID: 30563746 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 15, 2018 Category: Cancer & Oncology Authors: Farhat L, Mnejja W, Fourati N, Daoud H, Sahnoun T, Ben Kridis W, Ghorbel A, Frikha M, Siala W, Daoud J Tags: Cancer Radiother Source Type: research

[Quality and safety policy implementation for a new radiotherapy device].
Abstract Modern radiotherapy techniques (intensity-modulated radiotherapy, volumetric-modulated arctherapy, image-guided radiotherapy) or stereotactic radiotherapy are in expansion in most French cancer centres. The arrival of such techniques requires updates of existing equipment or implementation of new radiotherapy devices with adapted options. With the arrival of these new devices, there is a need to develop a quality and safety policy. This is necessary to ease the process from the setup to the first treated patient. The quality and safety policy is maintained to ensure the quality assurance of the radiothera...
Source: Cancer Radiotherapie - December 14, 2018 Category: Cancer & Oncology Authors: Martin C, Jumeau R, Blais E, Canova CH, Klausner G, Dumas R, Rouger A, Pariente F, Lyothier A, Slama Y, Dol J, Perret J, Jenny C, Chea M, Pasdeloup F, Maingon P, Troussier I Tags: Cancer Radiother Source Type: research

Radiation therapy after sentinel lymph node biopsy for early stage breast cancer using a magnetic tracer: Results of a single institutional prospective study of tolerance.
CONCLUSION: The results of this large-scale study show that the radiotherapy after sentinel lymph node biopsy using super paramagnetic iron oxide particles is feasible, and that no increase of the toxicity was observed. PMID: 30553652 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 12, 2018 Category: Cancer & Oncology Authors: Bazire L, Alran S, El Bamrani S, Gaujal L, Vincent-Salomon A, Tardivon A, Kirova YM Tags: Cancer Radiother Source Type: research

[Which photon energy for intensity-modulated radiotherapy and volumetric-modulated arctherapy in 2019?]
uml;l A Abstract For more than a decade, the majority of radiation oncology centres have been delivering intensity-modulated radiotherapy (then volumetric-modulated arctherapy) with 6 MV photons as their standard of care. This « dogma » had been supported by the usual absence of dosimetric advantages with high-energy photons (15 to 18 MV or more), at least for the planning target volume and the dose received by the adjacent organs at risk, and by the neutron component as soon as the photon energy exceeds 10 MV. Recent data could question such a dogma. First, in 2019, one cannot avoid taking i...
Source: Cancer Radiotherapie - December 11, 2018 Category: Cancer & Oncology Authors: Cosset JM, Nassef M, Saïdi R, Pugnaire J, Ben Abdennebi A, Noël A Tags: Cancer Radiother Source Type: research

[Cost of radiotherapy for bone metastases in France: A monocentric retrospective study].
A, Noël G Abstract PURPOSE: The cost of radiotherapy is a concern for health systems. The conventional non fractionated or multifractionated schemes have shown the same efficacy in terms of pain relief but a non fractionated treatment seems less expensive. However, in general practice, multifractionated treatments are still the majority, which represents an additional cost for society. Moreover, the use of stereotactic body radiotherapy becomes more democratic and offers new curative perspectives, but at what price? MATERIAL AND METHODS: A monocentric retrospective study was conducted in a French radiot...
Source: Cancer Radiotherapie - December 4, 2018 Category: Cancer & Oncology Authors: Le Fèvre C, Menoux I, Pin Y, Antoni D, Thiéry A, Noël G Tags: Cancer Radiother Source Type: research

Rare histologic types of rectal cancer: A monocentric cases series report.
CONCLUSION: The present study highlights the rarity and the specificities of uncommon histologic types of rectal cancer. We report the real-life management and outcome of rare histologic types of rectal cancers, with dismal prognosis of stage IV tumours. We also report that treatments were adapted to histology. PMID: 30509567 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - November 30, 2018 Category: Cancer & Oncology Authors: Vallard A, Diao P, Garcia MA, Pigné G, Vial N, Forest F, Peoc'h M, Langrand-Escure J, Magné N Tags: Cancer Radiother Source Type: research

Clinical assessment of palliative radiotherapy for pancreatic cancer.
CONCLUSIONS: Following treatment, pain and clinical symptoms were improved in a considerable proportion of patients with pancreatic cancer, proving that palliative radiotherapy is feasible for pancreatic cancer. PMID: 30401617 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - November 3, 2018 Category: Cancer & Oncology Authors: Tian Q, Zhang F, Wang Y Tags: Cancer Radiother Source Type: research

[Siriade 2.0: An e-learning platform for radiation oncology contouring].
CONCLUSION: Siriade 2.0 is an innovating digital tool for radiation oncology initial and continuous education. PMID: 30360973 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 22, 2018 Category: Cancer & Oncology Authors: Bibault JE, Denis F, Roué A, Gibon D, Fumagalli I, Hennequin C, Barillot I, Quéro L, Paumier A, Mahé MA, Servagi Vernat S, Créhange G, Lapeyre M, Blanchard P, Pointreau Y, Lafond C, Huguet F, Mornex F, Latorzeff I, de Crevoisier R, Martin V, Kreps S, Tags: Cancer Radiother Source Type: research

Outcomes and treatments of IB1 cervical cancers with high recurrence risk: A 13 years' experience.
CONCLUSION: In current clinical practice, tailored treatments are delivered, and seems to give correct therapeutic index. However, clinical trials are needed to standardise treatment according to patient characteristics and recurrence risk factors. PMID: 30348607 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 19, 2018 Category: Cancer & Oncology Authors: Espenel S, Garcia MA, Vallard A, Langrand-Escure J, Guy JB, Trone JC, Ben Mrad M, Chauleur C, de Laroche G, Moreno-Acosta P, Rancoule C, Magné N Tags: Cancer Radiother Source Type: research

Prevalence of burnout, depression and job satisfaction among French senior and resident radiation oncologists.
eau S Abstract PURPOSE: Cancer caregivers are at high risk of burn-out, with potential severe consequences on professionals' health and on patients' care. We have investigated the prevalence of burn-out and its impact in terms of psychological morbidity among French radiation oncologists. METHODS AND MATERIALS: An anonymous online questionnaire was advertised in all French senior radiation oncologists and residents, including demographical data, job-related stress factors, drug use, the Maslach Burn-out Inventory (MBI) and the General Health Questionnaire (GHQ-12). RESULTS: The response rates were 37% (7...
Source: Cancer Radiotherapie - October 19, 2018 Category: Cancer & Oncology Authors: Lazarescu I, Dubray B, Joulakian MB, Blanchard P, Chauvet B, Mahé MA, Mornex F, Rocher F, Thureau S Tags: Cancer Radiother Source Type: research

[Results of a retrospective study on radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma].
CONCLUSION: Eradication of Helicobacter pylori is the mainstay of treatment of gastric MALT. External irradiation is an effective and well-tolerated treatment modality in case of resistance to helicobacter eradication. PMID: 30337049 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 15, 2018 Category: Cancer & Oncology Authors: Ghorbal L, Hdiji A, Ben Salah H, Elloumi F, Frikha M, Elloumi M, Daoud J Tags: Cancer Radiother Source Type: research

[Radiation-induced lung toxicity predictors after stereotactic radiation therapy for non-small cell lung carcinoma stage I].
This article is a literature review of this complication's predictive factors. PMID: 30337050 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 15, 2018 Category: Cancer & Oncology Authors: Menoux I, Le Fèvre C, Noël G, Antoni D Tags: Cancer Radiother Source Type: research

Concepts and terms for dose/volume parameters in carbon-ion radiotherapy: Conclusions of the ULICE taskforce.
Conclusions of the ULICE taskforce. Cancer Radiother. 2018 Oct 13;: Authors: Vogin G, Wambersie A, Pötter R, Beuve M, Combs SE, Magrin G, Mayer R, Mock U, Sarrut D, Schreiner T, Fossati P, Balosso J Abstract PURPOSE: The Union of Light Ion Centers in Europe (ULICE) program addressed the need for uniting scientific results for carbon-ion radiation therapy obtained by several institutions worldwide in different fields of excellence, and translating them into a real benefit to the community. Particularly, the concepts for dose/volume parameters developed in photon radiotherapy cannot be extrapolated...
Source: Cancer Radiotherapie - October 13, 2018 Category: Cancer & Oncology Authors: Vogin G, Wambersie A, Pötter R, Beuve M, Combs SE, Magrin G, Mayer R, Mock U, Sarrut D, Schreiner T, Fossati P, Balosso J Tags: Cancer Radiother Source Type: research

Dosimetric analysis of stereotactic rotational versus static intensity-modulated radiation therapy for pancreatic cancer.
Abstract PURPOSE: Stereotactic body radiation therapy is a promising treatment modality for locally advanced pancreatic cancer. To determine the optimal radiation treatment, we compared the plan characteristics of volumetric-modulated arc therapy and intensity-modulated radiation therapy when administered with stereotactic body radiation therapy to treat pancreatic cancer. PATIENTS AND METHODS: Fifteen patients with locally advanced pancreatic cancer were treated by stereotactic body radiation therapy at a dose of 24-32Gy in four fractions with marker-guided gated volumetric-modulated arc therapy. Four dimens...
Source: Cancer Radiotherapie - October 12, 2018 Category: Cancer & Oncology Authors: Cho I, Park JW, Cho B, Kwak J, Yoon SM, Nesseler JP, Park J, Kim JH Tags: Cancer Radiother Source Type: research

Contouring workload in adjuvant breast cancer radiotherapy.
Abstract PURPOSE: To measure the impact of contouring on worktime in the adjuvant radiation treatment of breast cancer, and to identify factors that might affect the measurements. MATERIAL AND METHODS: The dates and times of contouring clinical target volumes and organs at risk were recorded by a senior and by two junior radiation oncologists. Outcome measurements were contour times and the time from start to approval. The factors evaluated were patient age, type of surgery, radiation targets and setup, operator, planning station, part of the day and day of the week on which the contouring started. The Welch ...
Source: Cancer Radiotherapie - October 12, 2018 Category: Cancer & Oncology Authors: Andrianarison VA, Laouiti M, Fargier-Bochaton O, Dipasquale G, Wang X, Nguyen NP, Miralbell R, Vinh-Hung V Tags: Cancer Radiother Source Type: research

[Multidisciplinary consultation for patients with HPV-related invasive carcinoma or precancerous lesions].
This study fits more broadly in a theme of clinical and fundamental research around cancers related to HPV. PMID: 30197024 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 6, 2018 Category: Cancer & Oncology Authors: Badoual C, Pavie J, Ménard M, Pernot S, Cochand-Priollet B, Hurel S, Péré H, Bats AS Tags: Cancer Radiother Source Type: research

[Hypofractioned radiotherapy in elderly patient with glioblastoma].
Abstract Glioblastoma is the most frequent primary brain tumor, with more than half of all patients being at least 65 years old. The treatment of the elderly in this pathology represents therefore a considerable challenge for oncologists and radiation therapists. However, in most clinical trials, age is a non-eligible criterial. In the last ten years, geriatric therapeutic trials have been multiplied. The treatment of glioblastoma consists of adjuvant chemoradiotherapy. In elderly patients, the evaluation of performans status and the molecular characteristics of the tumor are important factors in order to propose ...
Source: Cancer Radiotherapie - September 6, 2018 Category: Cancer & Oncology Authors: Kuntz L, Noel G, Antoni D Tags: Cancer Radiother Source Type: research

Combining radiation therapy and cancer immune therapies: From preclinical findings to clinical applications.
Abstract Besides its direct cytotoxic effect on the tumor cells, radiation therapy is also able to elicit an immune-mediated systemic anti-tumor response, resulting in tumor regression in irradiated sites but also within distant out of field secondary lesions and providing a long-term anti-tumor response. It is now clear that associating ionizing radiation with immune therapies can enhance radio-induced anti-tumor immune responses. Over the last decade, such a combination aroused considerable interest among the scientific community, with many preclinical models and clinical trials, using many types of immune thera...
Source: Cancer Radiotherapie - September 6, 2018 Category: Cancer & Oncology Authors: Bockel S, Durand B, Deutsch E Tags: Cancer Radiother Source Type: research

[Prevalence and expectations of "alternative and complementary medicine" use during radiotherapy in 2016: A prospective study].
[Prevalence and expectations of "alternative and complementary medicine" use during radiotherapy in 2016: A prospective study]. Cancer Radiother. 2018 Sep 06;: Authors: Dupin C, Arsène-Henry A, Charleux T, Haaser T, Trouette R, Vendrely V Abstract PURPOSE: Alternative and complementary medicine is defined as any substance or technique of non-allopathic medicine used to improve health and quality of life. The purpose of this prospective observational study was to evaluate the use of alternative and complementary medicine during radiotherapy. MATERIAL AND METHODS: A questionnaire w...
Source: Cancer Radiotherapie - September 6, 2018 Category: Cancer & Oncology Authors: Dupin C, Arsène-Henry A, Charleux T, Haaser T, Trouette R, Vendrely V Tags: Cancer Radiother Source Type: research

[Chemotherapy and chemoradiotherapy indications in the treatment of locally advanced gastric carcinoma].
aud R Abstract Currently, there is no international consensus on the best treatment regimen for patients with advanced resectable gastric carcinoma. Three approaches exist abroad continents. In France and Europe, perioperative chemotherapy and gastrectomy with D1.5 lymph-node dissection is the current standard. In Japan and South Korea, postoperative adjuvant chemotherapy after surgery with D2 lymph-node dissection is the standard treatment. In the United States, where limited lymph-node dissection is frequently performed, adjuvant chemoradiotherapy after surgery is the standard treatment. In France, postoperative...
Source: Cancer Radiotherapie - September 5, 2018 Category: Cancer & Oncology Authors: Quéro L, Guimbaud R Tags: Cancer Radiother Source Type: research

[Implementation of experience feedback committees meetings between the radiotherapy centres of Northern France by the regional oncology network].
This article details how such experiential feedback committees are implemented, what they can contribute and the barriers to such work at each stage of the project. PMID: 30195981 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 5, 2018 Category: Cancer & Oncology Authors: Viot C, Crombet S, Tokarski M Tags: Cancer Radiother Source Type: research

[Reference bases of radiotherapy under stereotaxic conditions for bronchopulmonary, hepatic, prostatic, upper aero-digestive, cerebral and bone tumors or metastases].
Abstract Since decades, stereotactic radiotherapy has spread out worldwide. Published results are very numerous. To clarify obviousness among all the publications, this recommendation review was written. Voluntarily, authors limited analysis of international best evidence literature on malignant tumors of lung, liver, prostate, head and neck, and metastasis of bone and brain. These data could be used to advance standardization and quality improvement of treatments performed in the nationwide radiotherapy departments and can provide useful guidance for centers worldwide. PMID: 30195982 [PubMed - as supplied by...
Source: Cancer Radiotherapie - September 5, 2018 Category: Cancer & Oncology Authors: Barillot I, Antoni D, Bellec J, Biau J, Giraud P, Jenny C, Lacornerie T, Lisbona A, Marchesi V, Mornex F, Supiot S, Thureau S, Noel G Tags: Cancer Radiother Source Type: research

[Anal canal cancer: In the era of intensity-modulated radiotherapy, outstanding issues].
Abstract Intensity-modulated radiotherapy makes possible to optimize the irradiation and spare normal tissues. The toxicity remains important with concomitant chemotherapy often associated. The improvement of MRI and PET-CT define more precisely the target volumes, which need a higher dose, but necessitates to respect the rules of contouring. The treatment is uniform whatever the stage but should be individualized based on clinical stage and tumor response. New paradigms concern biology, staging, volumes and doses, fractionation and combined treatments. PMID: 30181029 [PubMed - as supplied by publisher] (Sour...
Source: Cancer Radiotherapie - September 1, 2018 Category: Cancer & Oncology Authors: Peiffert D, Baumann AS, Serre AA, Vendrely V, Rouard N, Faivre JC, Vogin G Tags: Cancer Radiother Source Type: research

[Organization and risk management in stereotaxic body radiotherapy at the treatment station].
Abstract The development of stereotaxic body radiotherapy in the last decade has forced the radiotherapy departments to redouble their efforts in the fields of quality and risk management. For this purpose, increasingly complex and rigorous controls of high performance machines as well as a solid team training must be put in place. Extreme hypofractionation requires both increased vigilance at the treatment desk and well-defined and known procedures. The in place organizations contribute to the control of the risks related to the stereotaxic body radiotherapy machines. The medical presence at the beginning of the ...
Source: Cancer Radiotherapie - September 1, 2018 Category: Cancer & Oncology Authors: Bouvet C, Bertin K, Lafond C, Willaume D, de Crevoisier R, Leroy E Tags: Cancer Radiother Source Type: research

[Surgery after upfront radiochemotherapy for locally advanced esophageal cancer: To do or not to do?]
iac M Abstract The treatment of locally advanced esophageal cancer is still evolving. Surgery was considered as the backbone of the therapeutic management for a long time. Nowadays, chemoradiation has taken a major place in the neoadjuvant setting or as an exclusive treatment. Although some patients benefit from esophagectomy after chemoradiotherapy, a large subset of patients has no benefit and morbi-mortality rates are increased with a trimodality strategy. Patients who will have a local failure are at high risk of distant metastases in the follow-up. A third group of patients will have persistent locoregional d...
Source: Cancer Radiotherapie - August 30, 2018 Category: Cancer & Oncology Authors: Créhange G, Mabrut JY, Rouffiac M Tags: Cancer Radiother Source Type: research

[Rectal cancer radiotherapy: Therapeutical strategy and perspective].
Abstract Standard treatment consisting of chemoradiotherapy followed by radical surgery with total mesorectal excision, resulting in good oncologic local control but high morbidity and poor functional results. The same treatment applied to all patients presenting with low or mid T3-4 rectal tumors could result in overtreatment of small tumors. However, it remains insufficient (or unsatisfactory?) for locally advanced tumors regarding metastatic recurrence rate. Treatment is decided by a multidisciplinary board on the basis of initial staging, including MRI which allows for resection margin prediction and post...
Source: Cancer Radiotherapie - August 28, 2018 Category: Cancer & Oncology Authors: Vendrely V, Denost Q, Charleux T, Brouquet A, Huguet F, Rullier E Tags: Cancer Radiother Source Type: research

Combination of radiotherapy and immune treatment: First clinical data.
Abstract There is a very strong biological and pre-clinical rationale for combining radiotherapy with immune treatment. Radiation affects all steps in the immune response to antigens and clearly upregulates key-molecules on the cancer cell and in the tumor micro-environment, such as MHC class I antigens, tumor-associated antigens and the creation of neo-antigens as well. In many pre-clinical models, radiation together with the right combination and timing of immune therapy leads to regression of distant metastases, at remote non-irradiated sites of the body, the so-called "abscopal effects". The combinat...
Source: Cancer Radiotherapie - August 28, 2018 Category: Cancer & Oncology Authors: De Ruysscher D Tags: Cancer Radiother Source Type: research

[Hypofractionated radiotherapy in rectal cancer for elderly patients].
qih S Abstract Rectal cancer is a common pathology in the elderly. The standard for advanced rectal tumors is a chemoradiotherapy regimen combined 50Gy with concomitant chemotherapy followed by a surgery. This treatment induces interruptions of chemoradiotherapy and toxicities G3-4 more important in people over 70 years of age. Hypofractionated radiotherapy 5×5Gy with surgery following week is an alternative. All retrospective studies on this fractionation report an excellent immediate and chronic tolerance. The randomized phase III NACRE trial, comparing these 2 radiotherapy, followed by surgery at 6-8 week...
Source: Cancer Radiotherapie - August 27, 2018 Category: Cancer & Oncology Authors: Servagi Vernat S, Guilbert P, Bouché G, Ramiandrisoa F, Bellefqih S Tags: Cancer Radiother Source Type: research

[Management of patients with pacemakers or implantable cardioverter defibrillator undergoing radiotherapy].
dux C Abstract An increasing number of patients with cardiac implantable electronic devices benefit from radiotherapy, warranting specific collaborative management between both radiation oncologists and cardiologists. Interactions between electromagnetic fields, secondary particles and cardiac implantable electronic devices may result in transient and reversible malfunctions with significant consequences depending on the underlying cardiac pathology and the level of patient's cardiac implantable electronic devices dependency. Numerous international guidelines on patients' management have been proposed and all agre...
Source: Cancer Radiotherapie - August 25, 2018 Category: Cancer & Oncology Authors: Huertas A, Thuillot M, Bibault JE, Sharifzadehgan A, Laurans M, Giraud P, Lavergne T, Marijon É, Durdux C Tags: Cancer Radiother Source Type: research

[AFQSR: A concrete and active implication in the service of the radiotherapy in 2018].
Abstract AFQSR has demonstrated, since its creation, its dynamism, by participating in many working groups with the health authorities and national societies and by helping to ensure that quality, through the voice of the quality experts, constitutes a way to progress in the practice and exercise of radiotherapy. PMID: 30150088 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 24, 2018 Category: Cancer & Oncology Authors: Ponsard N Tags: Cancer Radiother Source Type: research

[Modalities and advantages of image guided radiation therapy of breast cancer in adjuvant setting].
Abstract In adjuvant setting, breast cancer radiotherapy volumes include whole mammary gland or chest wall, and when indicated, nodal area such as axilla, supraclavicular, and internal mammary chain. An accurate patients positioning is required due to some geometric complexity of target volumes closed to organs at risk as heart and lung. Image guided radiation therapy allows such accuracy. Here we propose a review on image guided radiotherapy for breast cancer. PMID: 30145089 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 22, 2018 Category: Cancer & Oncology Authors: Kammerer E, Fenoglietto P, Bourgier C Tags: Cancer Radiother Source Type: research

[The major debate: Micrometastases and breast cancer  - To be for nodal irradiation].
[The major debate: Micrometastases and breast cancer - To be for nodal irradiation]. Cancer Radiother. 2018 Aug 22;: Authors: Bourgier C, Lemanski C, Fenoglietto P, Azria D Abstract Standard of care in breast cancer management is well-defined. However, some gray zones still exist, in particular adjuvant radiotherapy indications in case of pN1mi breast cancer. Here we propose to define their prognosis, to underpin the benefit of adjuvant treatments in such patients' management and to define lymphedema risk, which is the most common late side effect of locoregional treatments. PMID: 30145...
Source: Cancer Radiotherapie - August 22, 2018 Category: Cancer & Oncology Authors: Bourgier C, Lemanski C, Fenoglietto P, Azria D Tags: Cancer Radiother Source Type: research

[Surgery or radiotherapy for oropharyngeal HPV-positive tumours?]
iat J Abstract Oropharyngeal carcinomas related to the human papilloma virus (HPV; usually HPV16) exhibit biological differences in terms of carcinogenesis and are of relatively better prognosis (in the absence of tobacco consumption) compared to tobacco-related cancers. The therapeutic strategies between these two forms of cancers of the upper aerodigestive tract related to different risk factors are however identical, except therapeutic trial. In the absence of a sufficient level of evidence to define a specific strategy for induced HPV carcinomas, the analysis of the recent literature nonetheless allows us to s...
Source: Cancer Radiotherapie - August 22, 2018 Category: Cancer & Oncology Authors: Philouze P, Céruse P, Thariat J Tags: Cancer Radiother Source Type: research

[Hypofractionnated radiotherapy for elderly patients with prostate cancer].
iot S Abstract Radiation therapy technique and schedules could be adapted to patient's age because of a natural history of prostate cancer perceived as different, taking into account the comorbidities of patients but also a particular tolerance of elderly subjects. Thus, in localized prostate cancer, evaluation of associated diseases is essential before considering a treatment that will be of interest only if the life expectancy is greater than 10 years. When a curative approach is decided, radiotherapy holds a place of choice. Due to the recent results of randomized studies evaluating moderate hypofractionnated r...
Source: Cancer Radiotherapie - August 22, 2018 Category: Cancer & Oncology Authors: Sargos P, Créhange G, Hennequin C, Latorzeff I, de Crevoisier R, Roubaud G, Supiot S Tags: Cancer Radiother Source Type: research

[Image-guided radiotherapy contribution and patient setup for anorectal cancer treatment].
Abstract Intensity-modulated radiation therapy is recommended in anal squamous cell carcinoma treatment and is increasingly used in rectal cancer. It adapts the dose to target volumes, with a high doses gradient. Intensity-modulated radiation therapy allows to reduce toxicity to critical normal structures and to consider dose-escalation studies or systemic treatment intensification. Image-guided radiation therapy is a warrant of quality for intensity-modulated radiation therapy, especially for successful delivery of the dose as planned. There is no recommended international or national anorectal cancer image-guide...
Source: Cancer Radiotherapie - August 21, 2018 Category: Cancer & Oncology Authors: Masson I, Delpon G, Vendrely V Tags: Cancer Radiother Source Type: research

[Hypofractionated radiotherapy for breast cancer in elderly patients: current evidence and future perspectives].
Abstract Adjuvant radiotherapy is the pillar of breast conserving surgery. Its omission is related with a higher risk of local recurrence and of breast cancer related or non-related mortality. It is of paramount importance to guarantee this treatment is fully administered to all patients after breast conserving surgery, including the elderly. In the last three decades several hypofractionated treatment schemes have shown their non-inferiority, allowing for treatment time reduction facilitating adhesion to treatment and reducing radiotherapy burden. This review focuses on the schemes and indications which have been...
Source: Cancer Radiotherapie - August 21, 2018 Category: Cancer & Oncology Authors: Rivin Del Campo E, Rivera S Tags: Cancer Radiother Source Type: research

[Image-guided radiotherapy for head and neck carcinoma].
Abstract Intensity-modulated radiotherapy, combined with chemotherapy, is the recommended treatment of locally advanced head and neck carcinoma, as a definitive treatment or as an adjuvant treatment following surgery. This technique offers the ability to sculpt the dose closely to the tumor volume. With this close conformity, it is essential to ensure that every day during the treatment the patient position and anatomy are similar to those at the time of treatment planning. Inevitably, there will be uncertainties introduced in this process and a planning target volume margins are added around the tumour volume to ...
Source: Cancer Radiotherapie - August 21, 2018 Category: Cancer & Oncology Authors: Beddok A, Blanchard P Tags: Cancer Radiother Source Type: research

The sentinel lymph node of breast cancer and the radiation oncologist.
;ro L Abstract If the indications of sentinel lymph node biopsy and axillary lymph node dissection have been the subject of many trials, the indications of radiotherapy, in the absence of axillary lymph node dissection are a matter of debate. We reviewed the available literature on this topic and tried to draw some practical applications. In case of negative result of a sentinel lymph node biopsy, patients could be viewed as having pN0 disease and indications of adjuvant radiotherapy based on this paradigm. However, when the result of a sentinel lymph node biopsy was positive and no axillary lymph node dissection ...
Source: Cancer Radiotherapie - August 20, 2018 Category: Cancer & Oncology Authors: Hennequin C, Guillerm S, Quéro L Tags: Cancer Radiother Source Type: research

[Analysis of immune microenvironment by multiplex immunohistochemistry in locally advanced non-small cell lung cancer: Principles and perspectives].
This article describes the potential of these assays in locally advanced non-small cell lung cancer. PMID: 30131267 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 18, 2018 Category: Cancer & Oncology Authors: Boulle G, Velut Y, Boni A, Lupo A, Alifano M, Trédaniel J, Giraud P, Damotte D Tags: Cancer Radiother Source Type: research

[Interest of image-guided radiotherapy for brain tumors and positioning control].
eneix S, Laprie A Abstract A narrow therapeutic index and more and more patients with long survival characterize primary and second brain tumors. Image-guided radiotherapy can increase accuracy of the patient's position during a course of intracranial irradiation thanks to a direct or indirect visualization of targets volumes. Treatment reproducibility and organ at risk-sparing are the primary issues, particularly with the development of stereotactic radiotherapy and protontherapy. Regarding intracranial treatments, image-guided radiotherapy seems to be a repetitive task based on skeletal structures registration. ...
Source: Cancer Radiotherapie - August 18, 2018 Category: Cancer & Oncology Authors: Legouté F, Padovani L, Claude L, Bolle S, Attal J, Gonzalez-Moya A, Lizée T, Paumier A, Jadaud É, Pointreau Y, Dufreneix S, Laprie A Tags: Cancer Radiother Source Type: research