Prone left-sided whole-breast irradiation: Significant heart dose reduction using end-inspiratory versus end-expiratory gating.
Abstract PURPOSE: To quantify the influence on heart dose metrics of prone left-sided whole-breast irradiation in an end-inspiratory phase (PrIN) versus an end-expiratory phase (PrEX). PATIENTS AND METHODS: Twenty patients underwent CT-simulation in PrIN and PrEX. Dynamic intensity-modulated radiotherapy was planned for whole-breast irradiation with a median prescription dose of 40.05Gy in 15 fractions and maximal sparing of the organs at risk. Dose-volume parameters were analyzed for heart, left anterior descending coronary artery, ipsilateral lung and both breasts. RESULTS: PrIN consistently reduced (P
Source: Cancer Radiotherapie - May 31, 2014 Category: Cancer & Oncology Authors: Mulliez T, Speleers B, Mahjoubi K, Remouchamps V, Gilsoul M, Veldeman L, Van den Broecke R, De Neve W Tags: Cancer Radiother Source Type: research

[Radiobiology of ablative dose in stereotactic irradiation: Update of the data.]
x F Abstract Stereotactic radiotherapy is a radiation technique, which is becoming more and more available and applicable for physicians. A good efficacy and safety are observed in clinical practice. However, the radiobiology of ablative radiation is still under question. The radiobiological principles of the 5R have to be discussed. The roles of hypoxia and vascularization, more specifically, angiogenesis and vasculogenesis seem to be dominating. PMID: 24860988 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 23, 2014 Category: Cancer & Oncology Authors: Antoni DN, Burckel H, Josset E, Noël G, Mornex F Tags: Cancer Radiother Source Type: research

[Equipment and positioning technologies in stereotactic body radiation therapy.]
Abstract Strereotactic body radiation therapy needs adapted or dedicated equipment to allow fulfilling the particular conditions of the stereotactic treatments: submillimetric accuracy during the treatment delivery, high doses for a reduced number of sessions. This kind of treatment can be either performed using delivery equipment conceived and dedicated to the technique, or performed on conventional machines adapted to meet the criteria. Contrary to intracranial treatments, the positioning of the target volume raises new difficulties, mainly due to the diversity of localization to treat and also due to inter- and...
Source: Cancer Radiotherapie - May 14, 2014 Category: Cancer & Oncology Authors: Marchesi V, Dedieu V, Lacornerie T, Buchheit I Tags: Cancer Radiother Source Type: research

Robotic stereotactic body radiation therapy for tumours of the liver: Radiation-induced liver disease, incidence and predictive factors.
CONCLUSION: Using robotic stereotactic body radiation therapy, the incidence of radiation-induced liver disease is weak and spontaneously reversible. Prospective studies are required to put in evidence other predictive factors of radiation-induced liver disease and confirm the optimal dose treatment. PMID: 24837351 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 14, 2014 Category: Cancer & Oncology Authors: Janoray G, Chapet S, Ruffier-Loubière A, Bernadou G, Pointreau Y, Calais G Tags: Cancer Radiother Source Type: research

[Large cell neuroendocrine carcinoma of the nasopharynx: A case report.]
We report a 35-year-old patient who consulted for tinnitus and nasal obstruction. The assessment found a nasopharyngeal tumour T4N0M0. The patient underwent 6 cycles of chemotherapy based on VP16 and cisplatin, followed by radiotherapy at a dose of 70Gy to the nasopharynx and 50Gy to the neck. The evolution was marked by clinical improvement and radiological stability. Six months after the end of treatment, the patient had a local and meningeal relapse. He received palliative care. He died 19 months after the end of treatment. PMID: 24837649 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 13, 2014 Category: Cancer & Oncology Authors: Elloumi F, Fourati N, Siala W, Ghorbell L, Jlidi R, Ghorbel A, Frikha M, Daoud J Tags: Cancer Radiother Source Type: research

[Glassy cell carcinoma: A rare cervix neoplasm. Case report of two patients and review of the literature.]
We report the cases of two patients with glassy cell carcinoma of the cervix with a review of the literature. PMID: 24819246 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 9, 2014 Category: Cancer & Oncology Authors: Lépinoy A, Lescut N, Lassabe C, Bosset JF, Servagi-Vernat S Tags: Cancer Radiother Source Type: research

[Indication of radiotherapy after neoadjuvant chemotherapy in breast cancer.]
ero L Abstract Indications for adjuvant radiotherapy in breast cancer are defined from the clinical data and the pathological extent of disease in the surgical specimen. Neoadjuvant chemotherapy could modify the pathological characteristics of the tumour, inducing a pathologic complete response in 15 to 50% of cases, challenging the classical indications of adjuvant radiotherapy. The benefit of adjuvant radiotherapy after neoadjuvant chemotherapy was not prospectively evaluated. Nonetheless, from retrospective series, some recommendations with a low level of proof could be given: (i) after lumpectomy, radiotherapy...
Source: Cancer Radiotherapie - May 9, 2014 Category: Cancer & Oncology Authors: Selz J, Le Scodan R, Ménard J, Hennequin C, Quero L Tags: Cancer Radiother Source Type: research

[Evaluation of therapeutic response after stereotactic body radiation therapy for liver tumours.]
This article presents a literature review of the various radiological changes observed after stereotactic body radiation therapy for liver tumours according to the multiple assessment methods used to determine local control. From the data available, we recommend using modified RECIST criteria proposed by the American Association for the Study of Liver Diseases (AASLD), as objective and relevant criteria of local control after stereotactic body radiation therapy for liver tumours. PMID: 24811896 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 5, 2014 Category: Cancer & Oncology Authors: Janoray G, Barillot I, Calais G Tags: Cancer Radiother Source Type: research

[Stereotactic radiotherapy for pelvic tumours.]
Abstract Extracranial stereotactic radiotherapy is booming. The development and spread of dedicated accelerators coupled with efficient methods of repositioning can now allow treatments of mobile lesions with moderate size, with high doses per fraction. Intuitively, except for the prostate, pelvic tumours, often requiring irradiation of regional lymph node drainage, lend little to this type of treatment. However, in some difficult circumstances, such as boost or re-radiation, stereotactic irradiation condition is promising and clinical experiences have already been reported. PMID: 24792995 [PubMed - as suppli...
Source: Cancer Radiotherapie - April 30, 2014 Category: Cancer & Oncology Authors: Mazeron R, Fumagalli I Tags: Cancer Radiother Source Type: research

[Stereotactic body radiation therapy and oligometastases.]
Abstract In stage IV cancers, locoregional management of primitive tumours as surgery and/or radiotherapy improved both progression-free survival and overall survival. Among metastatic cancer patients, some of them are considered as oligometastatic stage as they present few metastatic sites associated with low tumor aggressiveness. For those patients, metastatic local control, and therefore prolonged time to progression should be reached through local treatments as surgery and/or radiofrequency ablation and/or stereotactic radiotherapy. Here we propose a review of oligometastatic stage and results from extracrania...
Source: Cancer Radiotherapie - April 30, 2014 Category: Cancer & Oncology Authors: Bourgier C, Azria D, Fenoglietto P, Riou O, Almaghrabi MY, Supiot S, Mornex F, Giraud P Tags: Cancer Radiother Source Type: research

[Evaluation of transit in vivo dosimetry using portal imaging and comparison with measurements using diodes.]
CONCLUSION: The performance of EPIgray(®) in in vivo dosimetry is consistent with the recommendations of the European Society for Radiotherapy and Oncology (ESTRO) and equivalent to semiconductor diodes for 3D-CRT. It also allows adequate control for IMRT, which is technically difficult to perform with the diodes. PMID: 24792230 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 29, 2014 Category: Cancer & Oncology Authors: Royer P, Marchesi V, Rousseau V, Buchheit I, Wolf D, Peiffert D, Noël A Tags: Cancer Radiother Source Type: research

Comparison between the ICRU rectal point and modern volumetric parameters in brachytherapy for locally advanced cervical cancer.
CONCLUSION: In this large cohort of patients, the DICRU significantly underestimates the D2 cm(3). This difference probably results from the optimization process itself, which consists in increasing dwell times above the ICRU point in the cervix. Considering these findings, caution must be taken while implementing image-guided brachytherapy and dose escalation. PMID: 24751222 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 18, 2014 Category: Cancer & Oncology Authors: Mazeron R, Kamsu Kom L, Rivin Del Campo E, Dumas I, Farha G, Champoudry J, Chargari C, Martinetti F, Lefkopoulos D, Haie-Meder C Tags: Cancer Radiother Source Type: research

[Assessment of the response following stereotactic irradiation of lung primary tumours and metastases.]
Abstract Stereotactic radiotherapy is a standard treatment option for patients with stage I non-small cell lung cancer who are unfit for surgery or who are medically operable but refuse surgery. Comparable overall survival rates in operable patients are also supported by non-randomized single-institution and population based studies. Stereotactic radiotherapy has emerged as an alternative, effective and well tolerated in treating pulmonary oligometastases. The early detection of recurrence is important in the medically operable population for whom curative surgical salvage treatments are still available. A st...
Source: Cancer Radiotherapie - April 17, 2014 Category: Cancer & Oncology Authors: Barillot I, Munier O, Hatime M, Mornex F Tags: Cancer Radiother Source Type: research

[Radiotherapy as conservative therapy for sarcomas within irradiated field.]
nes M Abstract PURPOSE: To describe long-term outcome after combined-modality treatment including radiation therapy in patients with localized sarcoma within irradiated field. PATIENTS AND METHODS: Individual clinical data from all consecutive patients diagnosed and treated for a localized sarcoma within irradiated field between January 2000 and October 2011 at the Institut Claudius-Regaud, Toulouse, France, were retrospectively reviewed. RESULTS: Twenty-seven patients were eligible for this study. Ten patients were re-irradiated with a rate of unresectable, gross or microscopically positive margins dise...
Source: Cancer Radiotherapie - April 16, 2014 Category: Cancer & Oncology Authors: Modesto A, Filleron T, Chevreau C, Le Péchoux C, Rochaix P, Le Guellec S, Ducassou A, Gangloff D, Ferron G, Delannes M Tags: Cancer Radiother Source Type: research

[Prostate-rectum spacers: Optimization of prostate cancer irradiation.]
Abstract In the curative radiotherapy of localized prostate cancer, improvements in biochemical control observed with dose escalation have been counterbalanced by an increase in radiation-induced toxicity. The injection of biodegradable spacers between prostate and rectum represents a new frontier in the optimization of radiotherapy treatments for patients with localized disease. Transperineal injection of different types of spacers under transrectal ultrasound guidance allows creating a 7-to-20mm additional space between the prostate and the anterior rectal wall lasting 3 to 12 months. Dosimetrically, a relative ...
Source: Cancer Radiotherapie - April 16, 2014 Category: Cancer & Oncology Authors: Zilli T, Benz E, Miralbell R Tags: Cancer Radiother Source Type: research

[Radiotherapy plus concomitant systemic therapies for patients with brain metastases from breast cancer.]
This article sums up the different radiotherapy plus concomitant systemic therapies combinations for the treatment of brain metastases from breast cancer. PMID: 24731405 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 11, 2014 Category: Cancer & Oncology Authors: Cao KI, Kirova YM Tags: Cancer Radiother Source Type: research

[Radiotherapy in central neurocytoma and review of literature.]
Abstract Central neurocytoma is a rare primary central nervous system tumour of young adults with good prognosis. Typical and atypical forms are described according to various histologic and histopathologic parameters. Central neurocytoma develops in the periventricular areas and is revealed by increased intracranial pressure. The tumour exhibits typical characteristics on CT scan and MRI and a characteristic peak of glycine on spectroscopy-MRI. The main treatment is total resection, which is achievable only in half of the cases. External beam therapy improves local control of partially resected and/or atypical ce...
Source: Cancer Radiotherapie - April 4, 2014 Category: Cancer & Oncology Authors: Canova CH, Riet FG, Idbaih A, Mokhtari K, Mazeron JJ, Feuvret L Tags: Cancer Radiother Source Type: research

[Safety and efficacy of whole breast irradiation with a concomitant boost: Analysis of 121 cases treated at the institut de cancérologie de Lorraine.]
CONCLUSIONS: The study shows that whole breast radiation therapy with a concomitant boost is safe and effective for selected patients with low risk of relapse, and gives excellent long term results. This protocol represents a good alternative to longer standard whole breast radiation therapy with sequential boost to the lumpectomy bed. PMID: 24679650 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 25, 2014 Category: Cancer & Oncology Authors: Renoult F, Marchal C, Brunaud C, Harter V, Peiffert D Tags: Cancer Radiother Source Type: research

[Small cell neuroendocrine carcinoma of the uterine cervix: Report of six cases and a review of the literature.]
Abstract Neuroendocrine carcinoma is a rare and aggressive malignant tumour, mainly developing at the expense of the respiratory and of the digestive tract. Gynecological neuroendocrine tumours are rare and small cell neuroendocrine tumours of the uterine cervix represent 2% of cervical cancer. Given their rarity and the lack of randomized trials, the diagnostic and therapeutic management of these tumors is difficult and essentially based on that of pulmonary neuroendocrine tumours. Like the latter, and despite multimodality regimens, the prognosis of these tumours remains poor. Through this series, we report our ...
Source: Cancer Radiotherapie - March 19, 2014 Category: Cancer & Oncology Authors: Bellefqih S, Khalil J, Mezouri I, Kebdani T, Benjaafar N Tags: Cancer Radiother Source Type: research

[Impact of dynamic IMRT and tomotherapy in pelvic cancers: A prospective dosimetric study with 51 patients.]
CONCLUSION: In pelvis cancer with nodal irradiation, Rapid'Arc and helical tomotherapy provided very similar plans. The clinical evaluation of Artpelvis study will verify this equivalence hypothesis. PMID: 24647427 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 16, 2014 Category: Cancer & Oncology Authors: Servagi-Vernat S, Giraud P, Fenoglietto P, Azria D, Lisbona A, de La Rochefordière A, Zefkili S, Fau P, Resbeut M, Huger S, Peiffert D, Meyer P, Noël G, Mazurier J, Latorzeff I, Biston MC, Pommier P, Ledu D, Garcia R, Chauvet B, Dudouet P, Belhomme S, K Tags: Cancer Radiother Source Type: research

Potential impact of cardiac dose-volume on acute cardiac toxicity following concurrent trastuzumab and radiotherapy.
Abstract PURPOSE: To analyse the risk factors associated with acute cardiotoxicity in HER2-positive breast cancer patients receiving concurrent trastuzumab and radiotherapy. PATIENTS AND METHODS: Medical records of 45 breast cancer patients treated between 02/2009 and 02/2011 by concurrent trastuzumab and radiotherapy were collected. Radiation was delivered to the conserved breast or chest wall with or without regional nodes. Dose prescription was 50Gy in 25 fractions over five weeks with a tumor bed boost of 10Gy in 5 fractions in breast conservation. Acute cardiotoxicity (grade≥1) was defined using NCI-C...
Source: Cancer Radiotherapie - March 15, 2014 Category: Cancer & Oncology Authors: Cao L, Hu WG, Kirova YM, Yang ZZ, Cai G, Yu XL, Ma JL, Guo XM, Shao ZM, Chen JY Tags: Cancer Radiother Source Type: research

[Small cell carcinoma of the ovary.]
We report a case in a 34-year-old patient, revealed by a pelvic pain. The imaging found a large mass of the right ovary. The patient had right oophorectomy and total hysterectomy, a left oophorectomy, pelvic and a para-aortic lymphadenectomy. She subsequently received 6 cycles of adjuvant chemotherapy followed by pelvic radiation therapy. The hypercalcemic small cell carcinoma of the ovary is a rare disease of poor prognosis. Treatment approaches include surgery, chemotherapy with the addition of radiotherapy. PMID: 24637019 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 14, 2014 Category: Cancer & Oncology Authors: Bahri M, Lahmar R, Ben Salah H, Kallel N, Ben Amar M, Daoud J Tags: Cancer Radiother Source Type: research

[Breast ductal carcinoma in situ with microinvasion: Pathological review and clinical implications.]
CONCLUSION: The risk of initial lymph node involvement and delayed invasive local relapse deserve an optimal locoregional management including lymph node evaluation. The non-negligible discrepancy's rate between in situ and microinvasive components justifies HR status and HER2 expression assessment on the microinvasive component. PMID: 24637020 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 14, 2014 Category: Cancer & Oncology Authors: Modesto A, Gandy C, Mery E, Filleron T, Massabeau C, Izar F, Charitansky H, Roché H, de Lafontan B Tags: Cancer Radiother Source Type: research

[Radiation therapy of cardiac sarcomas.]
CONCLUSION: A scheme of 45Gy in 1.8Gy per fraction to a preoperative volume with an additional dose of 14Gy in 7 fractions on areas at risk or residual disease and margins 1cm, may be proposed based on the preliminary data of this study. Intensity modulated radiotherapy with daily cone-beam CT-scanner should be evaluated. PMID: 24637021 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 14, 2014 Category: Cancer & Oncology Authors: Thariat J, Clément-Colmou K, Vogin G, Beckendorf V, Ducassou A, Ali AM, Salas S, Saada E, Thyss A, Lapeyre M, Isambert N Tags: Cancer Radiother Source Type: research

[Post-surgery radiation therapy for a patient with osteogenesis imperfecta: About one case.]
We report the case of a 49-year-old woman with a breast cancer in the context of osteogenesis imperfecta. Dosimetric considerations permitting to reduce chess dose level have been performed for this patient. With a follow-up of 6 months, no imaging fracture has been revealed after radiotherapy. No evident conclusion about radiation injury from a case report could be described in case of osteogenesis imperfecta. To our knowledge, this is the first case which take into account potential radiation induced toxicities. PMID: 24629322 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 10, 2014 Category: Cancer & Oncology Authors: Ducournau A, Lagarde P, Henriques de Figueiredo B, Antoine M, Breton-Callu C, Petit A, Dallaudière B, Sargos P Tags: Cancer Radiother Source Type: research

[Isolated pelvic recurrences of cervical carcinoma treated with salvage chemoradiotherapy.]
CONCLUSION: In our experience, chemoradiotherapy can achieve a high rate of remission in patients with isolated pelvic recurrence of cervical cancer. This treatment is feasible only if the patient had not received radiation therapy before or if the relapse is out of the previously irradiated volume. PMID: 24462252 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 23, 2014 Category: Cancer & Oncology Authors: Besson N, Touboul E, Daraï E, Lefranc JP, Monnier L, Schlienger M, Huguet F Tags: Cancer Radiother Source Type: research

[Radiation therapy of sinonasal natural killer/T-cell lymphoma.]
Abstract Natural killer (NK)/T-cell lymphoma are part of lymphoproliferative diseases, they are rare in Europe and the United States but relatively common in Asia and South America. Natural killer (NK)/T-cell lymphoma present clinically as destructive lesions of the upper aerodigestive tract with perforation of deep structures of the face, destruction of the palate or an invasion of orbits. Treatment modalities of these lymphomas are still discussed because of the lack of available studies and the rarity of this disease. Radiotherapy provides a rapid control of the disease and is positioned as a major treatment of...
Source: Cancer Radiotherapie - January 22, 2014 Category: Cancer & Oncology Authors: Riet FG, Canova CH, Gabarre J, Ben Hassine S, Kamsu Kom L, Mazeron JJ, Feuvret L Tags: Cancer Radiother Source Type: research

[IMRT in cervix cancer: Towards a new standard?]
der C Abstract Intensity modulated radiation therapy has demonstrated its ability to prevent xerostomia in the treatment of head and neck cancers, as well as post-radiation related proctitis in prostate cancer. In the management of cervical carcinomas, many published dosimetric studies have shown its ability to limit the irradiation of organs at risk. However, clinical data remain limited to comparisons of cohorts, mostly retrospective, but promising. This review aims to update the current state of knowledge. PMID: 24461378 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 21, 2014 Category: Cancer & Oncology Authors: Mazeron R, Dumas I, El Khouri C, Lévy A, Attar M, Haie-Meder C Tags: Cancer Radiother Source Type: research

Interobserver variability of clinical target volume delineation in soft-tissue sarcomas.
CONCLUSIONS: This observational study highlighted that, in the absence of specific instructions or guidelines, the interobserver variability can be significant both in postoperative and preoperative radiotherapy of soft-tissue sarcomas. PMID: 24440683 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 16, 2014 Category: Cancer & Oncology Authors: Genovesi D, Ausili Cèfaro G, Trignani M, Vinciguerra A, Augurio A, Di Tommaso M, Perrotti F, De Paoli A, Olmi P, Valentini V, Di Nicola M Tags: Cancer Radiother Source Type: research

Stereotactic radiotherapy for large solitary brain metastases.
CONCLUSIONS: This study provides data to support that fractionated stereotactic radiation therapy without whole brain radiation therapy with a margin dose of 3 fractions of 7.7Gy for treatment of solitary large brain metastases is efficient and well-tolerated. Because of the significant improvement in overall survival, this schedule should be assessed in a randomized trial. PMID: 24439342 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 14, 2014 Category: Cancer & Oncology Authors: Feuvret L, Vinchon S, Martin V, Lamproglou I, Halley A, Calugaru V, Chea M, Valéry CA, Simon JM, Mazeron JJ Tags: Cancer Radiother Source Type: research

[Differentiation from local tumour recurrence and radionecrosis after stereotactic radiosurgery for treatment of brain metastasis.]
We report the case of a patient who underwent surgery for a single, left frontal brain metastasis of a breast carcinoma, followed by adjuvant stereotactic radiotherapy in the operative bed. Seven months after, she presented a local change in the irradiated area on the perfusion-weighted MRI, for which the differentiation between a local tumour recurrence and radionecrosis was not possible. PET with 2-deoxy-((18)F)-fluoro-D-glucose (FDG) revealed a hypermetabolic lesion. After surgical resection, the histological assessment has mainly recovered radionecrosis with few carcinoma cells. The multimodal MRI has greatly contribut...
Source: Cancer Radiotherapie - January 13, 2014 Category: Cancer & Oncology Authors: Patsouris A, Augereau P, Tanguy JY, Morel O, Menei P, Rousseau A, Paumier A Tags: Cancer Radiother Source Type: research

[Pineal metastasis of breast cancer: Case report and review.]
We report a case of pineal metastasis occurring in a 76-year-old woman treated for breast carcinoma in our department. PMID: 24418000 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 10, 2014 Category: Cancer & Oncology Authors: Kanoun Belajouza S, Jaidane O, Labidi M, Kraiem C, Bouaouina N Tags: Cancer Radiother Source Type: research

Helical tomotherapy in oncodermatology: Case report of circumferential cutaneous lymphoma treated by this optimized radiotherapy.
We report the usefulness of this approach for the treatment of complex lesions such as circumferential cutaneous lymphoma of the trunk. PMID: 24418001 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 10, 2014 Category: Cancer & Oncology Authors: Servy A, Kramkimel N, Franck N, Park S, Kirova YM Tags: Cancer Radiother Source Type: research

[Are molecular subtypes and Ki67 expression predictors of locoregional relapse in breast cancer patients with negative lymph nodes after mastectomy: The Institut Curie-Hôpital René-Huguenin experience and literature review.]
[Are molecular subtypes and Ki67 expression predictors of locoregional relapse in breast cancer patients with negative lymph nodes after mastectomy: The Institut Curie-Hôpital René-Huguenin experience and literature review.] Cancer Radiother. 2013 Dec 31; Authors: Selz J, Stevens D, Jouanneau L, Labib A, Le Scodan R Abstract PURPOSE: To evaluate the prognostic value of Ki67 expression, breast cancer molecular subtypes and the impact of postmastectomy radiotherapy in breast cancer patients with pathologic negative lymph nodes (pN0) after modified radical mastectomy. PATIENTS AND METHODS: S...
Source: Cancer Radiotherapie - December 31, 2013 Category: Cancer & Oncology Authors: Selz J, Stevens D, Jouanneau L, Labib A, Le Scodan R Tags: Cancer Radiother Source Type: research

[Evaluation and choice of imaging protocols on the Elekta XVI(®) kilovoltage cone-beam computed tomography imaging system.]
CONCLUSION: The study showed that theoretical values proposed by the manufacturer could be used to estimate the average dose delivered to the patient by the kV-CBCT imaging system. The analysis of all the results led to the implementation of a procedure allowing to optimize and account for the dose delivered to the patient by the CBCT imaging system and to report it in the patient folder. PMID: 24387926 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 30, 2013 Category: Cancer & Oncology Authors: Werlé F, Buffard E, Brune K, Perrin B, Atlani D Tags: Cancer Radiother Source Type: research

[Radiation therapy for pleomorphic adenoma of the parotid.]
This article aims at reviewing histological and radiological criteria and the surgical techniques. To improve local control, adjuvant irradiation (in first intention or after recurrence) may be useful but is still controversial for benign tumors in young patients with a risk of radio-induced cancer. We listed studies in which adjuvant radiotherapy was used so as to define its place in the treatment strategy. Prognostic factors were found by some authors. Other studies have to be done before strong evidence-based recommendations are issued. PMID: 24387927 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 30, 2013 Category: Cancer & Oncology Authors: Jardel P, Fakhry N, Makeieff M, Ferrie JC, Milin S, Righini C, Lacout A, Costes V, Malard O, Marcy PY, Guevara N, Odin G, Bensadoun RJ, Thariat J Tags: Cancer Radiother Source Type: research

[Follicular dendritic cell sarcoma in head and neck region.]
We report two head and neck cases, of favorable outcome after surgery and radiotherapy. Histopathology and differential diagnoses are discussed as well as the therapeutic strategies used. PMID: 24373643 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 24, 2013 Category: Cancer & Oncology Authors: Cerda T, Sun XS, Cazorla A, Laurent C, Floret F, Haudebourg J, Thyss A, Thariat J Tags: Cancer Radiother Source Type: research

[Brachytherapy training: A survey of French radiation oncology residents.]
CONCLUSION: Our study shows the interest of French residents for brachytherapy but suggests that practical teaching courses and an evaluation of the existing theoretical courses are warranted. PMID: 24332865 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 11, 2013 Category: Cancer & Oncology Authors: Fumagalli I, Faivre JC, Thureau S, Bibault JE, Diaz O, Leroy T, Pichon B, Riou O, Fournier C, Hannoun-Lévi JM, Peiffert D Tags: Cancer Radiother Source Type: research

[Preliminary results of whole breast helical tomotherapy with simultaneous integrated boost in the adjuvant treatment of breast cancer.]
CONCLUSIONS: Helical tomotherapy can achieve full target coverage while protected to the heart and ipsilateral lung. This treatment was well tolerated and reproducible. However, the low doses to normal tissue volumes need to be reduced in future studies. PMID: 24316350 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 5, 2013 Category: Cancer & Oncology Authors: Liem X, Chira C, Fourquet A, Campana F, Peurien D, Fournier-Bidoz N, Kirova YM Tags: Cancer Radiother Source Type: research

[Localized primary bone lymphoma: About four cases.]
CONCLUSION: The treatment of primary bone lymphoma is based on a combination of chemotherapy (with or without anti-CD20) and radiotherapy. The prognosis is excellent when it is localized. PMID: 24316351 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 5, 2013 Category: Cancer & Oncology Authors: Ben Salah H, Fourati N, Elloumi M, Boudawara T, Frikha M, Daoud J Tags: Cancer Radiother Source Type: research

[Potential indications for helical tomotherapy in breast cancers.]
CONCLUSIONS: Indications to retain intensity-modulated radiation therapy would consist of bilateral lesions, pectus excavatum, past thoracic irradiation (Hodgkin's disease) and complex volumes in obese or overweight patients. PMID: 24314856 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 4, 2013 Category: Cancer & Oncology Authors: Lamberth F, Guilbert P, Gaillot-Petit N, Champagne C, Looten-Vieren L, Nguyen TD Tags: Cancer Radiother Source Type: research

[A rare case of bone metastasis from gastro-intestinal stromal tumour: Place of radiotherapy.]
We report the case of a 56-year-old male presenting with bone lesions six years after initial surgical resection. We discuss through this paper the possibilities of management of these lesions and the place of radiotherapy. PMID: 24315043 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 3, 2013 Category: Cancer & Oncology Authors: Heymann S, Imperiale A, Schlund-Schoettel E, Sauer B, Dourthe LM Tags: Cancer Radiother Source Type: research

[Results of definitive radiotherapy for squamous cell carcinomas of the larynx patients with subglottic extension.]
CONCLUSION: This analysis suggests that the results for squamous cell carcinoma patients treated with radiotherapy/chemoradiotherapy are comparable to those obtained for other laryngeal tumors. This thus suggests the feasibility of laryngeal preservation protocols for infringement subglottic for selected cases. Further studies are needed to clarify these preliminary data. PMID: 24309002 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 2, 2013 Category: Cancer & Oncology Authors: Lévy A, Blanchard P, Janot F, Temam S, Bourhis J, Daly-Schveitzer N, Tao Y Tags: Cancer Radiother Source Type: research

[Radio-induced breast morphoea: An unrecognized complication.]
l G Abstract Morphoea is a localized scleroderma. Since the 1990s, it is described as a complication after irradiation for breast cancer. This complication is unrecognized and underdiagnosed. Irradiation seems to be a factor inducing an autoimmune process. Clinicians should be aware in case of an erythema in a treated area, appearing on average one year after the end of the irradiation. Histology alone can prove the diagnosis and rule out differential diagnoses: principally mastitis (carcinomatous, infectious), chronic radiodermatitis or radiation recall. Treatment of this rare complication is not consensual; it i...
Source: Cancer Radiotherapie - December 2, 2013 Category: Cancer & Oncology Authors: Vigneron C, Bauer N, Waisse W, Keller A, Pop M, Clavier JB, Salze P, Noël G Tags: Cancer Radiother Source Type: research

[Clinical aspects of brain metastases from nasopharyngeal carcinoma.]
Abstract Metastasis to the central nervous system, either through a hematogenous route or through the cerebrospinal fluid, is extremely rare in nasopharynx cancer. We aim to expose clinical aspects, therapeutic features and prognosis of nasopharyngeal carcinoma with brain metastases. We retrospectively reviewed the medical history of about 420 patients with nasopharyngeal carcinoma treated during 17 years at the university hospital of Sfax (Tunisia). Among them, three patients had brain metastasis. We excluded patients with direct extension to the brain. Tumours of the nasopharynx were locally advanced. ...
Source: Cancer Radiotherapie - November 20, 2013 Category: Cancer & Oncology Authors: Elloumi F, Ben Amor M, Ghorbel L, Mnif H, Boudawara T, Ghorbel AM, Frikha M, Daoud J Tags: Cancer Radiother Source Type: research

[Is there a role for pelvic lymphadenectomy before radiation therapy in localized prostate carcinoma?]
The objective of this review is to discuss these points and to present the clinical situations in which a pelvic lymphadenectomy performed before the irradiation of a prostate cancer, either exclusive or associated to an androgen deprivation, keeps a potential benefit. PMID: 24269015 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - November 20, 2013 Category: Cancer & Oncology Authors: Bachaud JM, Latorzeff I, Soulié M Tags: Cancer Radiother Source Type: research

[Is there any difference in therapeutic results of nasopharyngeal carcinoma between adults and children?]
CONCLUSION: Despite locally advanced disease in children, therapeutic results were better than in adults but not statistically significant. The use of treatment combination (chemotherapy and radiotherapy) in juvenile nasopharyngeal carcinoma may explain our findings. PMID: 24269016 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - November 20, 2013 Category: Cancer & Oncology Authors: Daoud J, Ghorbal L, Siala W, Elloumi F, Ghorbel A, Frikha M Tags: Cancer Radiother Source Type: research

[Helical tomotherapy in the treatment of malignant pleural mesothelioma: The impact of low doses on pulmonary and oesophageal toxicity.]
ute; MA, Giraud P Abstract PURPOSE: To evaluate the adjuvant treatment of malignant pleural mesothelioma by helical tomotherapy and the impact of low doses on esophageal and pulmonary toxicity. PATIENTS AND METHODS: Between June 2007 and May 2011, 29 patients diagnosed with malignant pleural mesothelioma received adjuvant radiotherapy by helical tomotherapy. The median age was 63 years (34-72). Histologically, 83 % of patients had epithelioid malignant pleural mesothelioma. Clinically, 45 % of patients were T3 and 55 % N0. Eighty six percent of the patients were treated by e...
Source: Cancer Radiotherapie - November 20, 2013 Category: Cancer & Oncology Authors: Helou J, Clément-Colmou K, Sylvestre A, Campion L, Amessis M, Zefkili S, Raphael J, Bonnette P, Le Pimpec Barthes F, Périgaud C, Mahé MA, Giraud P Tags: Cancer Radiother Source Type: research

[Radiotherapy and implantable medical device: Example of infusion pumps.]
We report here on the case of a patient who we treated with pelvic radiotherapy for cervical cancer and who had an infusion pump in iliac fossa. We conducted a series of tests on five identical pumps that insured that the treatment protocol is harmless to the implanted device. PMID: 24268844 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - November 19, 2013 Category: Cancer & Oncology Authors: Abrous-Anane S, Benhassine S, Lopez S, Cristina K, Mazeron JJ Tags: Cancer Radiother Source Type: research

Chemotherapy alone versus chemotherapy followed by consolidative radiotherapy for limited-stage aggressive non-Hodgkin's lymphoma: A meta-analysis of randomized controlled trials.
CONCLUSION: Chemotherapy followed by involved field radiotherapy, as compared with chemotherapy alone, is associated with better event-free survival, but no survival benefit is observed for patients for limited-stage aggressive non-Hodgkin's lymphoma. These results needed to be confirmed by high quality trials and further studies in the East. PMID: 24268845 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - November 19, 2013 Category: Cancer & Oncology Authors: Huang Z, Xu Z, Zhou Y Tags: Cancer Radiother Source Type: research