[Repair and time-dose factor: The example of spinal cord irradiation].
ch É Abstract The question whether a reirradiation is possible, with either curative of palliative intent, is a frequent issue and a true therapeutic challenge, in particular for a critical organ sensitive to cumulative dose, such as the spinal cord. Preclinical experimental data, based on debatable models that are hardly transferable to patients, suggest that there is a possibility of reirradiation, beyond the classical threshold for dose constraints, taking into account the "time-dose factor". Although the underlying biological mechanisms are however uncertain, scarce clinical data seem to confi...
Source: Cancer Radiotherapie - September 6, 2017 Category: Cancer & Oncology Authors: Chargari C, Maroun P, Louvel G, Drouet M, Riccobono D, François S, Dhermain F, Cosset JM, Deutsch É Tags: Cancer Radiother Source Type: research

[Toxicity and quality of life comparison of iodine 125  brachytherapy and stereotactic radiotherapy for prostate cancers].
[Toxicity and quality of life comparison of iodine 125 brachytherapy and stereotactic radiotherapy for prostate cancers]. Cancer Radiother. 2017 Sep 06;: Authors: Gnep K, Lizée T, Campillo-Gimenez B, Delpon G, Droupy S, Perrier L, de Crevoisier R Abstract Quality of life is a major issue for good prognostic prostate cancer, for which brachytherapy is one of the reference treatments. Stereotactic Body Radiotherapy (SBRT) is a recent alternative however not yet validated as a standard treatment. This review of the literature reports and compares the toxicities and the quality of life, either...
Source: Cancer Radiotherapie - September 6, 2017 Category: Cancer & Oncology Authors: Gnep K, Lizée T, Campillo-Gimenez B, Delpon G, Droupy S, Perrier L, de Crevoisier R Tags: Cancer Radiother Source Type: research

[Dose constraints to organs at risk for conformational and stereotactic radiotherapy: Small bowel and duodenum].
Bosschère L, Maingon P Abstract Radiotherapy of abdominopelvic primary or secondary lesions in conformational or stereotactic techniques is in full development. The small bowel is highly sensitive to irradiation and is the main organ at risk limiting prescription doses. This literature review aims to define the dose constraints to the small bowel and the duodenum in conformational and stereotactic body radiotherapy. The small bowel including the duodenum, jejunum and ileum is delineated on the simulation scanner. The radio-induced intestinal toxicities are acute related to the cellular depopulation of the i...
Source: Cancer Radiotherapie - September 5, 2017 Category: Cancer & Oncology Authors: Goupy F, Chajon E, Castelli J, Le Prisé É, Duvergé L, Jaksic N, Vogin G, Monpetit É, Klein V, de Bosschère L, Maingon P Tags: Cancer Radiother Source Type: research

[Lung dose constraints for normo-fractionated radiotherapy and for stereotactic body radiation therapy].
Abstract Radiation-induced lung disease (RILD) is common after radiation therapy and represents cornerstone toxicities after treatment of thoracic malignancies. From a review of literature, the objective of this article was to summarize clinical and non-clinical parameters associated with the risk of RILD in the settings of normo-fractionated radiotherapy and stereotactic body radiation therapy (SBRT). For the treatment of lung cancers with a normo-fractionated treatment, the mean lung dose (MLD) should be below 15-20Gy. For a thoracic SBRT, V20Gy
Source: Cancer Radiotherapie - September 5, 2017 Category: Cancer & Oncology Authors: Blais E, Pichon B, Mampuya A, Antoine M, Lagarde P, Kantor G, Breton-Callu C, Lefebvre C, Gerard M, Aamarcha A, Ozsahin M, Bourhis J, Maingon P, Troussier I, Pourel N Tags: Cancer Radiother Source Type: research

[Doses to organs at risk for conformational and stereotactic radiotherapy: Bladder].
R, Azria D Abstract Bladder dose constraints in case of conformational radiotherapy/intensity-modulated radiotherapy and stereotactic radiotherapy are reported from the literature, in particular from the French radiotherapy society RECORAD recommendations, according to the treated pelvic tumor sites. The dose-volume effect on urinary toxicity is not clearly demonstrated, making difficult to establish absolute dose constraints for the bladder. In case of high-dose prostate cancer radiotherapy, the bladder dose constraints are: V60Gy
Source: Cancer Radiotherapie - September 4, 2017 Category: Cancer & Oncology Authors: Duvergé L, Castelli J, Lizée T, de Crevoisier R, Azria D Tags: Cancer Radiother Source Type: research

[Implementation of the tracer patient audit in a private radiation therapy centre].
Abstract The "tracer patient" audit is an evaluation method introduced by the French health authority in the V2014 certification. This is not mandatory in private radiotherapy centres. In our continuous quality improvement approach and in order to improve the management of patient care, the management of our radiation therapy centre has decided to use this method to evaluate our medical practice and to engage healthcare professionals at the core of this approach. PMID: 28870415 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 1, 2017 Category: Cancer & Oncology Authors: Nardin S, Pinto N, Bensadoun RJ Tags: Cancer Radiother Source Type: research

[Combination of radiotherapy and androgen deprivation therapy for localized prostate cancer].
Abstract Combination of radiotherapy and androgen deprivation is now considered as the standard of care for patients with a localized prostate cancer but poor prognosis factors. Two groups of randomized trials have led to this recommendation: some have compared radiotherapy alone versus hormonal treatment and radiotherapy: these trials demonstrated, now with a long follow-up, an improvement in 10-year survival for the combined treatment. Three recent trials compared androgen deprivation alone or combined with radiotherapy; a benefit in survival was also demonstrated in favour of the combination. Some questions rem...
Source: Cancer Radiotherapie - September 1, 2017 Category: Cancer & Oncology Authors: Hennequin C, Fumagalli I, Martin V, Quero L Tags: Cancer Radiother Source Type: research

Reimbursement of radiotherapy in Germany.
Abstract Reimbursement of radiotherapy in Germany is mainly based on a certain fixed fee for treatment planning and patient set up in addition to payment per fraction. This applies to outpatient care for patients with public health insurance or private health insurance. Payment per fraction has a considerable influence on reimbursement of inpatients as well. The advantage of payment per fraction is the simplicity and transparency. The disadvantage is an inadequate reimbursement for new treatment modalities like hypofractionation or stereotactic body radiotherapy. PMID: 28867459 [PubMed - as supplied by publis...
Source: Cancer Radiotherapie - August 31, 2017 Category: Cancer & Oncology Authors: Schmidberger H Tags: Cancer Radiother Source Type: research

[Doses to organs at risk in conformational radiotherapy and stereotaxic irradiation: The heart].
Abstract Radiation therapy of breast cancer, Hodgkin lymphoma, lung cancer and others thoracic irradiations induce an ionizing radiation dose to the heart. Irradiation of the heart, associated with patient cardiovascular risk and cancer treatment-induced cardiotoxicity, increase cardiovascular mortality. The long survival after breast or Hodgkin lymphoma irradiation requires watching carefully late treatment toxicity. The over-risk of cardiac events is related to the dose received by the heart and the irradiated cardiac volume. The limitation of cardiac irradiation should be a priority in the planning of thoracic ...
Source: Cancer Radiotherapie - August 31, 2017 Category: Cancer & Oncology Authors: Vandendorpe B, Servagi Vernat S, Ramiandrisoa F, Bazire L, Kirova YM Tags: Cancer Radiother Source Type: research

[Computational medical imaging (radiomics) and potential for immuno-oncology].
cute; C, Robert C Abstract The arrival of immunotherapy has profoundly changed the management of multiple cancers, obtaining unexpected tumour responses. However, until now, the majority of patients do not respond to these new treatments. The identification of biomarkers to determine precociously responding patients is a major challenge. Computational medical imaging (also known as radiomics) is a promising and rapidly growing discipline. This new approach consists in the analysis of high-dimensional data extracted from medical imaging, to further describe tumour phenotypes. This approach has the advantages of bei...
Source: Cancer Radiotherapie - August 30, 2017 Category: Cancer & Oncology Authors: Sun R, Limkin EJ, Dercle L, Reuzé S, Zacharaki EI, Chargari C, Schernberg A, Dirand AS, Alexis A, Paragios N, Deutsch É, Ferté C, Robert C Tags: Cancer Radiother Source Type: research

[Role and interest of induction chemotherapy for head and neck cancers].
Abstract Induction chemotherapy must be integrated in a global approach for locally advanced head and neck cancer. Its use has theoretical advantages but should not compromise locoregional radiotherapy. Induction chemotherapy is a standard for organ preservation with the use of the TPF scheme to avoid total laryngectomy without compromising survival data. It is more controversial in other locally advanced head and neck cancer because concurrent chemoradiotherapy is the standard of care. It may be an option for patients with significant lymph node invasion to reduce the occurrence of distant metastasis. PMID: ...
Source: Cancer Radiotherapie - August 30, 2017 Category: Cancer & Oncology Authors: Pointreau Y, Schick U, Huguet F Tags: Cancer Radiother Source Type: research

[Description of the GORTEC 2017-03 study: Postoperative stereotactic radiotherapy for early stage oropharyngeal and oral cavity cancer with high risk margin (PHRC-K-16-164)].
Abstract The GORTEC 2017-03-Stereo-postop study is a phase 2, multicentric, nationwide study, funded by the hospital clinical research program (PHRC). The sponsor is Centre Jean-Perrin in Clermont-Ferrand, in partnership with the GORTEC. The principal investigators are Dr J Biau and Dr M Lapeyre. The main objective is to study severe late toxicity of postoperative stereotactic radiotherapy (6×6Gy) for early stage oropharyngeal and oral cavity cancer with high risk margins. The secondary objectives include acute toxicity, efficacy, nutritional impact and quality of life. The population is adult patients, with...
Source: Cancer Radiotherapie - August 30, 2017 Category: Cancer & Oncology Authors: Biau J, Miroir J, Millardet C, Saroul N, Pham-Dang N, Racadot S, Huguet F, Kwiatkowski F, Pereira B, Bourhis J, Lapeyre M Tags: Cancer Radiother Source Type: research

[Radiotherapy for head and neck squamous cell carcinoma: State of the art and future directions].
Abstract Therapeutic principles of radiation therapy in head and neck carcinomas will be discussed in this review. Intensity-modulated radiotherapy with concomitant cisplatin should be standard. In case of contraindication to chemotherapy, cetuximab is an option, while hyperfractionation should be considered in patients unfit for concomitant treatment. Concomitant chemotherapy should be administered in the presence of extracapsular extensions and positive margins in the postoperative setting. Current research areas such as desescalation in human papillomavirus-positive tumours, adaptive radiotherapy, radiomics and...
Source: Cancer Radiotherapie - August 29, 2017 Category: Cancer & Oncology Authors: Schick U, Huguet F, Pointreau Y, Pradier O Tags: Cancer Radiother Source Type: research

[Combination external beam radiation and brachytherapy boost for prostate cancer].
nge G Abstract Brachytherapy as sole treatment is standard of care for D'Amico classification low-risk prostate cancer. For intermediate and high-risk patients, brachytherapy can be associated to external beam radiation therapy to better take into account the risk of extracapsular effraction and/or seminal vesicle involvement. Three randomized studies have shown that this association increases freedom from relapse survival compared to exclusive external beam radiation therapy. This benefit is not shown for overall survival. The addition of a hormonal therapy to this association is most likely mandatory for high-ri...
Source: Cancer Radiotherapie - August 29, 2017 Category: Cancer & Oncology Authors: Chapet O, Bossi A, Horn S, Créhange G Tags: Cancer Radiother Source Type: research

[Who can be dismissed in rectal cancer management?]
Abstract Dramatic progress has deeply moved rectal cancer management. Tailoring of treatment allow to select participants according to initial prognostic factors (radiotherapist) or tumoral response (surgeon). Today, this management must keep in mind tumoral initial staging, prognostic at the time of diagnosis, tumoral response and characteristic, and patient's motivation. The result of this patient care is more than oncologic, it is also functional. PMID: 28864048 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 29, 2017 Category: Cancer & Oncology Authors: Rouanet P Tags: Cancer Radiother Source Type: research

Tumour-derived plasma cell-free DNA in patients with head and neck cancer: A short review.
k M Abstract Head and neck squamous cell carcinoma is one of the leading causes of cancer mortality worldwide. The prognosis for patients with head and neck squamous cell carcinoma has not substantially improved during the last decades, despite numerous advancements in treatment options. Reliable markers for early tumour detection and treatment response, which complement clinical examinations, imaging techniques, and biopsies would be extremely useful. One fairly new and promising method is the analysis of tumour-derived cell-free DNA (ctDNA) in the plasma of cancer patients. First data indicate that this method m...
Source: Cancer Radiotherapie - August 25, 2017 Category: Cancer & Oncology Authors: Rave-Fränk M Tags: Cancer Radiother Source Type: research

Brachytherapy for prostate cancer: Present and future.
vi JM Abstract Based on recent, important publications on the impact of brachytherapy in the management of prostate cancer, we analysed already validated indications and the "under investigations" use of brachytherapy. Published studies (MEDLINE), randomized trials and recommendations were reviewed, as well as Delphi consensus when available. While low-dose rate brachytherapy remains a standard of care for low-risk eligible patients, three randomized trials are now available to consider that combination of external beam radiation therapy with brachytherapy boost (low- or high-dose rate) appears as a reco...
Source: Cancer Radiotherapie - August 25, 2017 Category: Cancer & Oncology Authors: Hannoun-Lévi JM Tags: Cancer Radiother Source Type: research

[Active surveillance of prostate cancer].
Abstract Several prospective studies have demonstrated the safety of active surveillance as a first treatment of prostate cancer. It spares many patients of a useless treatment, with its potential sequelae. Patients with a low-risk cancer are all candidates for this approach, as recommended by the American Society of Clinical Oncology (ASCO). Some patients with an intermediate risk could be also concerned by active surveillance, but this is still being discussed. Currently, the presence of grade 4 lesions on biopsy is a contra-indication. Modalities included a repeated prostate specific antigen test and systematic...
Source: Cancer Radiotherapie - August 25, 2017 Category: Cancer & Oncology Authors: Ploussard G, Hennequin C, Rozet F Tags: Cancer Radiother Source Type: research

[Radiotherapy of oligometastatic pelvic node relapses in patients with prostate cancer].
Rio E Abstract The Oligopelvis 2 studies is based on the assumption that salvage pelvic radiotherapy may prolong the interval between the first and the second intermittent hormone therapy sequence in pelvic lymph node oligometastatic prostate cancer. This phase 3 study will compare intermittent hormone therapy (standard arm) alone or combined with salvage pelvic radiotherapy (experimental arm). PMID: 28847462 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 25, 2017 Category: Cancer & Oncology Authors: Supiot S, Doré M, Rio E Tags: Cancer Radiother Source Type: research

[What does the radiation oncologist expect from the physicist and inversely].
Abstract The cooperation between radiation oncologists and physicists is essential to guarantee the quality and safety of the irradiation of our patients. It would be wrong to consider that the intervention of physicists in the patient management process is limited to the provision of calibrated and controlled equipment and to guarantee the validity of the dose distribution and the treatment time, while the radiation oncologist has the complete control of all clinical activities related to irradiation. The intervention of physicists at the stage of acquisition of anatomical data and throughout the phase of optimiz...
Source: Cancer Radiotherapie - August 25, 2017 Category: Cancer & Oncology Authors: Barillot I Tags: Cancer Radiother Source Type: research

[Hypofractionated irradiation of prostate cancer: What is the radiobiological understanding in 2017?]
Abstract For prostate cancer, hypofractionation has been based since 1999 on radiobiological data, which calculated a very low alpha/beta ratio (1.2 to 1.5Gy). This suggested that a better local control could be obtained, without any toxicity increase. Consequently, two types of hypofractionated schemes were proposed: "moderate" hypofractionation, with fractions of 2.5 to 4Gy, and "extreme" hypofractionation, utilizing stereotactic techniques, with fractions of 7 to 10Gy. For moderate hypofractionation, the linear-quadratic (LQ) model has been used to calculate the equivalent doses of the new p...
Source: Cancer Radiotherapie - August 25, 2017 Category: Cancer & Oncology Authors: Cosset JM Tags: Cancer Radiother Source Type: research

[Stereotactic body radiation therapy for hepatic malignancies: Organs at risk, uncertainties margins, doses].
The objective of this paper is to improve the quality and safety and to help the diffusion of this technique for a majority of patients. In 2016, the French Society of Radiation Oncology (SFRO) published guidelines for external radiotherapy and brachytherapy ("Recorad"). This paper is an update of these recommendations considering recent publications. PMID: 28844506 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 24, 2017 Category: Cancer & Oncology Authors: Lacornerie T, Rio E, Mahé MA Tags: Cancer Radiother Source Type: research

[Implementation of "never events" checklists in a radiotherapy information system].
This article details this process. Prospects for improvement are also proposed, including a peer-to-peer audit on the use of checklists and the availability of the radiotherapy information system manufacturer to collaborate in this process to secure the patients' journey. PMID: 28826696 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 18, 2017 Category: Cancer & Oncology Authors: Brusadin G, Bour MS, Deutsch E, Kouchit N, Corbin S, Lefkopoulos D Tags: Cancer Radiother Source Type: research

[Reirradiation of head and neck cancers].
;nézery K Abstract Locoregional relapse in previously irradiated region for head and neck tumours is associated with a bad locoregional and distant prognosis. Reirradiation might be exclusive, or feasible in addition with surgery and/or chemotherapy, according to histopronostic factors. Data show that reirradiation is feasible with some severe toxicity due to the bad prognosis of this situation. Hyperfractionnated regimen with split course or normofractionnated regimen without split course are possible with similar efficacy. If tumour size is small, stereotactic ablative radiotherapy may be considered, and ...
Source: Cancer Radiotherapie - August 18, 2017 Category: Cancer & Oncology Authors: Doyen J, Lam Cham Kee D, Krebs L, Guigay J, Dassonville O, Peyrade F, Poissonnet G, Saâda-Bouzid E, Sudaka A, Bozec A, Bénézery K Tags: Cancer Radiother Source Type: research

Detecting anomalies in a deliberately biased tomotherapy plan: Comparison of two patient-specific quality assurance processes involving ArcCHECK( ®) and Gafchromic(®) EBT3 films.
CONCLUSION: Both comparative methods showed ArcCHECK(®) processing is more suitable to detect the six errors introduced in the reference treatment plan. PMID: 28780318 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 2, 2017 Category: Cancer & Oncology Authors: Werlé F, Dehaynin N, Niederst C, Jarnet D, Gantier M, Karamanoukian D, Meyer P Tags: Cancer Radiother Source Type: research

[Normal tissue tolerance to external beam radiation therapy: Bone marrow and cortical bone structures].
This article focuses first on conventional irradiation or intensity modulation radiotherapy considering classical fractionation. Secondly, it focuses on stereotactic radiotherapy. The considered organs will be haematopoietic structures, and bone cortical structures. Current recommendations are summarised in a table. PMID: 28774489 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 31, 2017 Category: Cancer & Oncology Authors: Schernberg A, Hennequin C Tags: Cancer Radiother Source Type: research

[Hypofractionated stereotactic radiotherapy for brain metastasis: Benefit of additional whole brain radiotherapy?]
CONCLUSION: Whole brain irradiation improves local control of brain metastatic disease in addition to hypofractionated stereotactic radiotherapy. Sparing whole brain irradiation for salvage treatments only does not affect overall survival or risk of neurological death in selected patients with favourable prognosis. PMID: 28711413 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 12, 2017 Category: Cancer & Oncology Authors: Royer P, Salleron J, Vogin G, Taillandier L, Clément-Duchêne C, Klein O, Faivre JC, Peiffert D, Bernier V Tags: Cancer Radiother Source Type: research

[Technique of complex mammary irradiation: Mono-isocentric 3D conformational radiotherapy and helical tomotherapy].
CONCLUSIONS: Tomotherapy appears to provide better homogeneity and tumour coverage. This technique of irradiation may be justified in the case of morphological situations such as pectus exavatum and in complex clinical situations. In other cases, conformal radiotherapy in mono-isocentric technique remains to be favoured. PMID: 28693911 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 7, 2017 Category: Cancer & Oncology Authors: Vandendorpe B, Guilbert P, Champagne C, Antoni T, Nguyen TD, Gaillot-Petit N, Servagi Vernat S Tags: Cancer Radiother Source Type: research

[MRI-based radiotherapy planning].
ier R Abstract MRI-based radiotherapy planning is a topical subject due to the introduction of a new generation of treatment machines combining a linear accelerator and a MRI. One of the issues for introducing MRI in this task is the lack of information to provide tissue density information required for dose calculation. To cope with this issue, two strategies may be distinguished from the literature. Either a synthetic CT scan is generated from the MRI to plan the dose, or a dose is generated from the MRI based on physical underpinnings. Within the first group, three approaches appear: bulk density mapping assign...
Source: Cancer Radiotherapie - July 6, 2017 Category: Cancer & Oncology Authors: Largent A, Nunes JC, Lafond C, Périchon N, Castelli J, Rolland Y, Acosta O, de Crevoisier R Tags: Cancer Radiother Source Type: research

[Hypofractionated stereotactic body radiation therapy for adrenal metastases].
This article aims to present a review of published studies to date on stereotactic radiotherapy of adrenal metastases and to propose a treatment protocol. PMID: 28684242 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 3, 2017 Category: Cancer & Oncology Authors: Dupic G, Biau J, Bellière-Calandry A, Lapeyre M Tags: Cancer Radiother Source Type: research

[After nearly thirty years of radiation oncology in Cameroon: Regression or progress!]
PMID: 28645726 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 20, 2017 Category: Cancer & Oncology Authors: Yomi J, Ngano OS, Douanla A Tags: Cancer Radiother Source Type: research

[Evolution of radiotherapy techniques for Hodgkin disease: History and future].
PMID: 28629715 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 16, 2017 Category: Cancer & Oncology Authors: Kirova YM, Horn S, Chen JY Tags: Cancer Radiother Source Type: research

Low dose out-of-field radiotherapy, part 2: Calculating the mean photon energy values for the out-of-field photon energy spectrum from scattered radiation using Monte Carlo methods.
CONCLUSION: The out-of-field energy spectra and dose distribution data obtained in this study with Monte Carlo methods can be used to calibrate dosimeters to measure out-of-field radiation from 6MV photons. PMID: 28623063 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 13, 2017 Category: Cancer & Oncology Authors: Skrobala A, Adamczyk S, Kruszyna-Mochalska M, Skórska M, Konefał A, Suchorska W, Zaleska K, Kowalik A, Jackowiak W, Malicki J Tags: Cancer Radiother Source Type: research

[PET scan and NMR spectroscopy for the differential diagnosis between brain radiation necrosis and tumour recurrence after stereotactic irradiation of brain metastases: Place in the decision tree].
CONCLUSION: The criteria described in conventional MRI cannot by themselves establish the differential diagnosis. In first intention in case of doubt, PET scan should be done, combining the best sensitivity and specificity, whereas NMR spectroscopy used in combination does not improve these factors. PMID: 28599998 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 6, 2017 Category: Cancer & Oncology Authors: Menoux I, Noël G, Namer I, Antoni D Tags: Cancer Radiother Source Type: research

[Medical prevention and treatment of radiation-induced pulmonary complications].
te; N, Chargari C Abstract Radiation-induced lung injuries mainly include the (acute or sub-acute) radiation pneumonitis, the lung fibrosis and the bronchiolitis obliterans organizing pneumonia (BOOP). The present review aims at describing the diagnostic process, the current physiopathological knowledge, and the available (non dosimetric) preventive and curative treatments. Radiation-induced lung injury is a diagnosis of exclusion, since clinical, radiological, or biological pathognomonic evidences do not exist. Investigations should necessarily include a thoracic high resolution CT-scan and lung function tests wi...
Source: Cancer Radiotherapie - June 5, 2017 Category: Cancer & Oncology Authors: Vallard A, Rancoule C, Le Floch H, Guy JB, Espenel S, Le Péchoux C, Deutsch É, Magné N, Chargari C Tags: Cancer Radiother Source Type: research

[Feasibility and tolerance of Sienna+( ®) for the procedure of sentinel lymph node biopsy: Single centre pilot study of 30 consecutive patients].
[Feasibility and tolerance of Sienna+(®) for the procedure of sentinel lymph node biopsy: Single centre pilot study of 30 consecutive patients]. Cancer Radiother. 2017 May 26;: Authors: Ly N, Sauvan M, Chillès A, Ratour J, Musmesci N, Rouzier R, Tardivon A, Kirova YM, Alran S PMID: 28566247 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 26, 2017 Category: Cancer & Oncology Authors: Ly N, Sauvan M, Chillès A, Ratour J, Musmesci N, Rouzier R, Tardivon A, Kirova YM, Alran S Tags: Cancer Radiother Source Type: research

[Prognostic factors for head and neck cancer reirradiation: A systematic review].
CONCLUSIONS: Head and neck cancer reirradiation achieves long-term survival outcomes. However, regarding to its associated side effects, patients need to be carefully selected based on prognostic factors. PMID: 28566248 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 26, 2017 Category: Cancer & Oncology Authors: Ohnleiter T, Truntzer P, Antoni D, Guihard S, Elgard AM, Noël G Tags: Cancer Radiother Source Type: research

[Risk of radionecrosis after hypofractionated stereotactic radiotherapy targeting the postoperative resection cavity of brain metastases].
CONCLUSION: Analysis of patients and treatment variables revealed that infratentorial location of brain metastases was predictive for radionecrosis after hypofractionated stereotactic radiotherapy for postoperative resection cavities. PMID: 28551018 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 24, 2017 Category: Cancer & Oncology Authors: Keller A, Doré M, Antoni D, Menoux I, Thillays F, Clavier JB, Delpon G, Jarnet D, Bourrier C, Lefebvre F, Chibbaro S, Darié I, Proust F, Noël G Tags: Cancer Radiother Source Type: research

First French experiences of total body irradiations using helical TomoTherapy( ®).
CONCLUSION: Total body irradiation using helical TomoTherapy(®) guaranteed high dose homogeneity throughout the body and dose verification was achievable, showing small difference between planned and delivered doses. PMID: 28532617 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 19, 2017 Category: Cancer & Oncology Authors: Sun R, Cuenca X, Itti R, Nguyen Quoc S, Vernant JP, Mazeron JJ, Jenny C, Chea M Tags: Cancer Radiother Source Type: research

[Pain flare following palliative external beam radiotherapy: Prospective study of 41 cases].
CONCLUSION: Radiotherapy is an effective treatment of pain related to bone metastasis, but with a high incidence of painful exacerbation. PMID: 28532618 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 19, 2017 Category: Cancer & Oncology Authors: Lachgar A, Sahli N, Benjaafar N Tags: Cancer Radiother Source Type: research

[Immunotherapy and radiotherapy].
nex F Abstract Radiotherapy, primarily known for its cytotoxic effect on the tumor cells, via the induction of DNA damages, has the ability to induce a systemic antitumoral response. By an immunologic cell death, tumor cells exposed to radiation release a large amount of neoantigenes and pro-inflammatory mediators, acting as an in situ vaccine, resulting in an tumor regression within the primary irradiated site, but also in the distant "out of field" secondary tumors. However, this phenomenon is extremly rare with radiotherapy alone, suggesting that the radiation-induced antitumor immunity is not suffici...
Source: Cancer Radiotherapie - May 15, 2017 Category: Cancer & Oncology Authors: Bockel S, Antoni D, Deutsch É, Mornex F Tags: Cancer Radiother Source Type: research

A large French multicenter retrospective series of T1-T2N0 vocal cords carcinomas treated with exclusive irradiation.
CONCLUSION: Radiotherapy provides good results in local control of stage I and II vocal cords cancers as well as the toxicity level. PMID: 28522278 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 15, 2017 Category: Cancer & Oncology Authors: Robert A, Pointreau Y, Janoray G, Bardet É, Fesneau M, Garaud P, Chapet S, Lafond C, Dupuis O, Calais G Tags: Cancer Radiother Source Type: research

[Stereotactic lung radiotherapy: Technical setting up on Novalis Tx( ®) and single centre prospective study of the 100 first malignant pulmonary nodules treated at centre Jean-Perrin].
CONCLUSION: Stereotactic lung radiotherapy is an effective treatment for inoperable stage I non-small-cell lung cancer and lung oligometastases of well informed and selected patients. Initial respiratory state, and especially the diffusing capacity of the lungs for carbon monoxide corrected for alveolar volume, seems to be important for tolerance. PMID: 28522279 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 15, 2017 Category: Cancer & Oncology Authors: Bellière-Calandry A, Dupic G, Magnier F, Chassin V, Dedieu V, Lapeyre M Tags: Cancer Radiother Source Type: research

Primary spinal glioma in children: Results from a referral pediatric institution in Shanghai.
CONCLUSION: Our preliminary results are consistent with that of other similar published reports, however longer follow up is needed. So are specific recommendations that are still lacking in this setting. PMID: 28522280 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 15, 2017 Category: Cancer & Oncology Authors: Khalil J, Chuanying Z, Qing Z, Belkacémi Y, Mawei J Tags: Cancer Radiother Source Type: research

[Cancer, radiotherapy and immune system].
Abstract Novel paradigms emerge in oncology today. Systemic treatments are more effective and diversified along with an increased life expectancy in oligometastatic patients. Stereotactic radiotherapy using hypofractionation opens new perspectives for local tumour control. The area of radiobiology has expanded with integration of tumour microenvironment in which radiation-induced inflammation mediators and immune system play a major role. Immunity checkpoints inhibitors experience a major development. This rapidly evolving field seems involved in the abscopal effects, especially when radiation is combined with che...
Source: Cancer Radiotherapie - May 10, 2017 Category: Cancer & Oncology Authors: Nesseler JP, Peiffert D, Vogin G, Nickers P Tags: Cancer Radiother Source Type: research

[Radiotherapy volume delineation based on ((18)F)-fluorodeoxyglucose positron emission tomography for locally advanced or inoperable oesophageal cancer].
Abstract PURPOSE: To study the impact on radiotherapy planning of an automatically segmented target volume delineation based on ((18)F)-fluorodeoxy-D-glucose (FDG)-hybrid positron emission tomography-computed tomography (PET-CT) compared to a manually delineation based on computed tomography (CT) in oesophageal carcinoma patients. METHODS AND MATERIALS: Fifty-eight patients diagnosed with oesophageal cancer between September 2009 and November 2014 were included. The majority had squamous cell carcinoma (84.5 %), and advanced stage (37.9 % were stade IIIA) and 44.8 % had middle oesopha...
Source: Cancer Radiotherapie - May 9, 2017 Category: Cancer & Oncology Authors: Encaoua J, Abgral R, Leleu C, El Kabbaj O, Caradec P, Bourhis D, Pradier O, Schick U Tags: Cancer Radiother Source Type: research

[Spinal stereotactic body radiotherapy: French assessment in 2016].
CONCLUSION: This study identified some consistency of practices in some aspects despite the lack of consensus guidelines. Nevertheless, further studies are needed to establish consensus of planning and treatment. PMID: 28499659 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 9, 2017 Category: Cancer & Oncology Authors: Pougnet I, Jaegle E, Garcia R, Tessier F, Faivre JC, Louvel G, Gross E, Gonzague L, Benchalal M, Ducteil A, Supiot S, Autret D, Clavier JB, Mirabel X, Bellière A, Wdowczyk D, Heymann S, Barillot I, de La Lande B, Passerat V, Sunyach MP, Lipinski F, Thibo Tags: Cancer Radiother Source Type: research

Stereotactic radiation therapy of brain metastases from colorectal cancer: A single institution cohort.
We report the efficacy and safety of hypofractionnated stereotactic radiation therapy and stereotactic radiosurgery, and its role in colorectal cancer brain metastasis management. METHODS AND MATERIAL: Between June 2010 and December 2014, fifteen consecutive patients received hypofractionnated stereotactic radiation therapy or stereotactic radiosurgery as first local therapy or following surgical removal for colorectal cancer brain metastases. The primary endpoint was overall survival. Secondary endpoints were brain progression free survival, in field control rates and safety. RESULTS: Median follow-up was 41 mon...
Source: Cancer Radiotherapie - May 9, 2017 Category: Cancer & Oncology Authors: Paix A, Antoni D, Adeduntan R, Noël G Tags: Cancer Radiother Source Type: research

Second malignancies after permanent implant prostate cancer brachytherapy: A single-institution study of 675  patients treated between 1999 and 2003.
CONCLUSION: With a mean follow-up of more than 11 years, this series does not detect any excess risk of second cancers associated with permanent implant prostate brachytherapy. However, due to power limitation, a small increase in the risk of secondary malignancies cannot be totally ruled out. PMID: 28499661 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 9, 2017 Category: Cancer & Oncology Authors: Cosset JM, Belin L, Wakil G, Flam T, Thiounn N, Pierrat N, Pontvert D, Savignoni A, Chauveinc L Tags: Cancer Radiother Source Type: research

[Acute toxicity of breast cancer irradiation with modulated intensity by tomotherapy( ®)].
[Acute toxicity of breast cancer irradiation with modulated intensity by tomotherapy(®)]. Cancer Radiother. 2017 May 09;: Authors: Aoulad N, Massabeau C, de Lafontan B, Vieillevigne L, Hangard G, Ciprian C, Chaltiel L, Moyal É, Izar F Abstract PURPOSE: Helical radiation intensity modulated by tomotherapy improves dose distribution to complex and large volumes. The aim of the study was to assess acute toxicity of this technique during breast cancer irradiation after conserving surgery or mastectomy. PATIENTS AND METHODS: Cutaneous toxicities, lung and oesophageal side effects, and breas...
Source: Cancer Radiotherapie - May 9, 2017 Category: Cancer & Oncology Authors: Aoulad N, Massabeau C, de Lafontan B, Vieillevigne L, Hangard G, Ciprian C, Chaltiel L, Moyal É, Izar F Tags: Cancer Radiother Source Type: research