[Radiotherapy for nasopharyngeal carcinoma].
Abstract Nasapharyngeal carcinoma is a rare disease. Oftenly, the diagnostic is made for advanced disease. Localized tumors, T1 or T2 NO observed a good prognosis and are locally controlled in more than 90 % of the cases by radiotherapy alone. The standard treatment of locally advanced disease is combined chemoradiation. A special vigilance of fast decrease of the volume of the pathological lymph nodes, sometimes associated to loss of weight might indicate an adaptive dosimetric revision. The treatment of recurrent disease is of great importance. Surgical indications are limited but should be discus...
Source: Cancer Radiotherapie - August 10, 2016 Category: Cancer & Oncology Authors: Maingon P, Blanchard P, Bidault F, Calmels L Tags: Cancer Radiother Source Type: research

[Quality and safety management for radiotherapy].
Abstract Quality and safety management have been implemented for many years in healthcare structures (hospitals treating cancer, private radiotherapy centres). Their structure and formalization have improved progressively over time. These recommendations aim at describing the link between quality and safety management through its organization scheme based on quality-safety policy, process approach, document management and quality measurement. Dedicated tools, such as experience feedback, a priori risk mapping, to-do-lists and check-lists are shown as examples and recommended as routine practice. PMID: 2752342...
Source: Cancer Radiotherapie - August 10, 2016 Category: Cancer & Oncology Authors: Pourel N, Meyrieux C, Perrin B Tags: Cancer Radiother Source Type: research

[Radiotherapy of bone metastases].
The objective of this paper is to report indications and treatment modalities of radiotherapy in these situations. PMID: 27523421 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 10, 2016 Category: Cancer & Oncology Authors: Thureau S, Vieillard MH, Supiot S, Lagrange JL Tags: Cancer Radiother Source Type: research

[Image-guided radiotherapy].
pon G Abstract The IGRT is described in its various equipment and implementation. IGRT can be based either on ionizing radiation generating 2D imaging (MV or kV) or 3D imaging (CBCT or MV-CT) or on non-ionizing radiation (ultrasound, optical imaging, MRI or radiofrequency). Adaptive radiation therapy is then presented in its principles of implementation. The function of the technicians for IGRT is then presented and the possible dose delivered by the on-board imaging is discussed. The quality control of IGRT devices is finally described. PMID: 27523422 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 10, 2016 Category: Cancer & Oncology Authors: de Crevoisier R, Chauvet B, Barillot I, Lafond C, Mahé M, Delpon G Tags: Cancer Radiother Source Type: research

[Radiotherapy of cervix and endometrial carcinoma].
mas L Abstract External irradiation and brachytherapy still have a major place in the treatment of cervix and endometrial carcinoma. This review presents the French guidelines in terms of preparation and choice of irradiation techniques of these gynecological malignancies. PMID: 27523423 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 10, 2016 Category: Cancer & Oncology Authors: Barillot I, Haie-Méder C, Charra Brunaud C, Peignaux K, Kerr C, Thomas L Tags: Cancer Radiother Source Type: research

[Radiotherapy of hypopharynx cancers].
lais G, Lapeyre M Abstract The intensity-modulated radiotherapy is the gold standard in the treatment of hypopharynx cancers. Early T1 and T2 tumours could be treated by exclusive radiotherapy or surgery. For tumours requiring total pharyngolaryngectomy (T2 or T3), induction chemotherapy followed by exclusive radiotherapy or concurrent chemoradiotherapy are possible. For T4 tumours, surgery must be proposed. The treatment of lymph nodes is based on the initial treatment of the primary tumour. In non-surgical procedure, in case of sequential radiotherapy, curative dose is 70Gy and prophylactic dose is 50Gy. An inte...
Source: Cancer Radiotherapie - August 9, 2016 Category: Cancer & Oncology Authors: Pointreau Y, Lafond C, Trémolières P, Legouté F, Servagi-Vernat S, Giraud P, Maingon P, Calais G, Lapeyre M Tags: Cancer Radiother Source Type: research

[Recommendations in case of radiation of patient with a pacemaker or an implantable defibrillator].
Abstract Patients with pacemakers or defibrillators have a relative contra-indication for radiotherapy. This review presents the precautions issued by the French agency for drug safety (ANSM). PMID: 27522186 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 9, 2016 Category: Cancer & Oncology Authors: Barillot I, Mazeron R, Mornex F, Giraud P Tags: Cancer Radiother Source Type: research

[Radiotherapy of breast cancer].
M, Mahé MA Abstract In breast cancer, radiotherapy is an essential component of the treatment. After conservative surgery for an infiltrating carcinoma, radiotherapy must be systematically performed, regardless of the characteristics of the disease, because it decreases the rate of local recurrence and by this way, specific mortality. Partial breast irradiation could not be proposed routinely but only in very selected and informed patients. For ductal carcinoma in situ, adjuvant radiotherapy must be also systematically performed after lumpectomy. After mastectomy, chest wall irradiation is required for pT3-...
Source: Cancer Radiotherapie - August 9, 2016 Category: Cancer & Oncology Authors: Hennequin C, Barillot I, Azria D, Belkacémi Y, Bollet M, Chauvet B, Cowen D, Cutuli B, Fourquet A, Hannoun-Lévi JM, Leblanc M, Mahé MA Tags: Cancer Radiother Source Type: research

[Radiotherapy during pregnancy].
Abstract The diagnostic of cancer during pregnancy is a rare and delicate situation. As the developments of the embryo and the human fetus are extremely sensitive to ionizing radiations, the treatment of these tumors should be discussed. The studies - preclinical and clinical - based mostly on exposure accidents show that subdiaphragmatic treatments are possible during pregnancy. When radiotherapy is used, phantom estimations of the dose to the fetus, confirmed by in vivo measurements are required. Irradiation and imaging techniques should be arranged to decrease as much as possible the dose de...
Source: Cancer Radiotherapie - August 9, 2016 Category: Cancer & Oncology Authors: Mazeron R, Barillot I, Mornex F, Giraud P Tags: Cancer Radiother Source Type: research

[Radiotherapy of skin cancers].
e; MA Abstract The indications of radiotherapy for skin cancers are not clearly defined because of the lack of randomised trials or prospective studies. For basal cell carcinomas, radiotherapy frequently offers a good local control, but a randomized trial showed that surgery is more efficient and less toxic. Indications of radiotherapy are contra-indications of surgery for patients older than 60, non-sclerodermiform histology and occurring in non-sensitive areas. Adjuvant radiotherapy could be proposed to squamous cell carcinomas, in case of poor prognostic factors. Dose of 60 to 70Gy are usually required, an...
Source: Cancer Radiotherapie - August 9, 2016 Category: Cancer & Oncology Authors: Hennequin C, Rio E, Mahé MA Tags: Cancer Radiother Source Type: research

[Consequences of prosthesis on quality of the radiation therapy].
ël G Abstract Dose prescription, delineation and dose calculation are clearly complicated when a patient have been operated on with insertion of prosthesis. Knowledge of the physical and material characteristics is needed to decrease incertitude of calculations. Recommendations for each step of treatments are proposed in this article allowing to optimization of the treatment safety. PMID: 27522190 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 9, 2016 Category: Cancer & Oncology Authors: Le Fèvre C, Buffard E, Antoni D, Chaussemy D, Matter-Parrat V, Noël G Tags: Cancer Radiother Source Type: research

Éditorial.
Éditorial. Cancer Radiother. 2016 Aug 9; Authors: Eschwège F PMID: 27521029 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 8, 2016 Category: Cancer & Oncology Authors: Eschwège F Tags: Cancer Radiother Source Type: research

[Radiotherapy of bladder cancer].
This article introduces the French recommendations for radiotherapy of bladder cancer: indications, exams, technique, dosimetry, delivery and image guidance. PMID: 27521030 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 8, 2016 Category: Cancer & Oncology Authors: Riou O, Chauvet B, Lagrange JL, Martin P, Llacer Moscardo C, Charissoux M, Lauche O, Aillères N, Fenoglietto P, Azria D Tags: Cancer Radiother Source Type: research

[Radiotherapy of lymphomas].
uin C Abstract Radiotherapy for Hodgkin's lymphoma has evolved over time but retains a dominant position in the treatment of early stage tumours. Its indications are more limited for non-Hodgkin's lymphomas, but the techniques follow the same principles whatever the histological type. This review presents the French recommendations in terms of preparation and choice of irradiation techniques. PMID: 27521031 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 8, 2016 Category: Cancer & Oncology Authors: Barillot I, Mahé MA, Antoni D, Hennequin C Tags: Cancer Radiother Source Type: research

[Guidelines for external radiotherapy and brachytherapy: 2nd edition].
vet B Abstract In 2007, a first edition was published with the objective to produce guidelines for optimization, harmonization and homogenization of practices in external radiation therapy in France. The second edition, including brachytherapy, has the same objective and takes into account recent technologic improvements (intensity modulation radiation therapy, stereotactic radiotherapy, and 3-dimension brachytherapy) and results of literature. The first part is about daily use of general principles (quality, security, image-guided radiation therapy) and the second is to describe each treatment step in main cancer...
Source: Cancer Radiotherapie - August 8, 2016 Category: Cancer & Oncology Authors: Mahé MA, Barillot I, Chauvet B Tags: Cancer Radiother Source Type: research

[Radiotherapy of oropharynx carcinoma].
Abstract Indication, doses, technique of radiotherapy and concomitant chemotherapy for oropharynx carcinoma are presented. The recommendations for delineation of the target volumes and organs at risk are detailed. PMID: 27521033 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 8, 2016 Category: Cancer & Oncology Authors: Servagi Vernat S, Tochet F, Vieillevigne L, Pointreau Y, Maingon P, Giraud P Tags: Cancer Radiother Source Type: research

[Common chapter dedicated to taking care about the preparation of irradiation of head and neck carcinoma].
Abstract The treatment of head and neck carcinoma by radiotherapy with or without chemotherapy or targeted agents requires a rigorous preparation, sometimes complex, frequently time consuming to guaranty to the patient to reduce as much as possible acute toxicity as well as late complications. These rules are valuable whatever the location of the primary with some anatomic variations. Intensity modulated radiotherapy and its rules are currently the standard of care for this disease. The follow-up of the patients during their treatment is similar. PMID: 27521034 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 8, 2016 Category: Cancer & Oncology Authors: Maingon P, Giraud P, Pointreau Y Tags: Cancer Radiother Source Type: research

[Hepatic tumors and radiotherapy].
Abstract Recent technological developments led to develop the concept of focused liver radiation therapy. We must distinguish primary and secondary tumors as the indications are restricted and must be discussed as an alternative to surgical or medical treatments. For hepatocellular carcinoma 5 to 10cm (or more), a conformational radiation with or without intensity modulation is performed. Stereotactic body radiotherapy (SBRT) is being evaluated and is increasingly proposed as an alternative to radiofrequency ablative treatment for primary or secondary tumors (typically less than 5cm). Tumor (and liver) moveme...
Source: Cancer Radiotherapie - August 8, 2016 Category: Cancer & Oncology Authors: Rio E, Mornex F, Peiffert D, Huertas A Tags: Cancer Radiother Source Type: research

[Guidelines for the radiotherapy of gliomas].
JJ Abstract Gliomas are the most frequent primary brain tumours. Treating these tumours is difficult because of the proximity of organs at risk, infiltrating nature, and radioresistance. Clinical prognostic factors such as age, Karnofsky performance status, tumour location, and treatments such as surgery, radiation therapy, and chemotherapy have long been recognized in the management of patients with gliomas. Molecular biomarkers are increasingly evolving as additional factors that facilitate diagnosis and therapeutic decision-making. These practice guidelines aim at helping in choosing the best treatment, in par...
Source: Cancer Radiotherapie - August 8, 2016 Category: Cancer & Oncology Authors: Feuvret L, Antoni D, Biau J, Truc G, Noël G, Mazeron JJ Tags: Cancer Radiother Source Type: research

[Radiotherapy of larynx cancers].
lais G, Lapeyre M Abstract Intensity-modulated radiotherapy is the gold standard in the treatment of larynx cancers (except T1 glottic tumour). Early T1 and T2 tumours may be treated by exclusive radiation or surgery. For tumours requiring total laryngectomy (T2 or T3), induction chemotherapy followed by exclusive radiotherapy or concurrent chemoradiotherapy is possible. For T4 tumour, surgery must be proposed. The treatment of lymph nodes is based on the initial treatment of the primary tumour. In non-surgical procedure, in case of sequential radiotherapy, the curative dose is 70Gy and the prophylactic dose is 50...
Source: Cancer Radiotherapie - August 8, 2016 Category: Cancer & Oncology Authors: Pointreau Y, Lafond C, Legouté F, Trémolières P, Servagi-Vernat S, Giraud P, Maingon P, Calais G, Lapeyre M Tags: Cancer Radiother Source Type: research

[Radiotherapy of carcinoma of the salivary glands].
Abstract Indication, doses, and technique of radiotherapy for salivary glands carcinoma are presented, and the contribution of neutrons and carbon ions. The recommendations for delineation of the target volumes and organs at risk are detailed. PMID: 27521038 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 8, 2016 Category: Cancer & Oncology Authors: Servagi-Vernat S, Tochet F Tags: Cancer Radiother Source Type: research

[Radiotherapy for oral cavity cancers].
Abstract Intensity modulated radiation therapy (IMRT) and brachytherapy are standard techniques for the irradiation of oral cavity cancers. These techniques are detailed in terms of indication, preparation, delineation and selection of the volumes, dosimetry and patient positioning control. PMID: 27521039 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 8, 2016 Category: Cancer & Oncology Authors: Lapeyre M, Biau J, Racadot S, Moreira JF, Berger L, Peiffert D Tags: Cancer Radiother Source Type: research

[The irradiation process].
é MA Abstract The purpose of this article is to describe the regulatory framework of the radiotherapy practice in France, the external irradiation and brachytherapy process and the guidelines for patient follow-up. PMID: 27516048 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 7, 2016 Category: Cancer & Oncology Authors: Barillot I, Chauvet B, Hannoun Lévi JM, Lisbona A, Leroy T, Mahé MA Tags: Cancer Radiother Source Type: research

[Radiotherapy for paediatric cancers].
Abstract The purpose of this article is to describe the specificities of paediatric radiation oncology: cancer types, radiotherapy indications, techniques, organisation and reglementary framework. PMID: 27516049 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 7, 2016 Category: Cancer & Oncology Authors: Laprie A, Padovani L, Bernier V, Supiot S, Huchet A, Ducassou A, Claude L Tags: Cancer Radiother Source Type: research

[Delineation of organs at risk and dose constraints].
t B Abstract From a review of literature, the objective of this paper is to define limits for delineation of organs at risk and dose constraints in this latter when radiotherapy is delivered with conventional fractionation or with hypofractionation as for stereotactic body radiation therapy. PMID: 27516050 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 7, 2016 Category: Cancer & Oncology Authors: Noël G, Antoni D, Barillot I, Chauvet B Tags: Cancer Radiother Source Type: research

[Prostate cancer external beam radiotherapy].
Abstract The prostate external beam radiotherapy techniques are described, when irradiating the prostate or after prostatectomy, with and without pelvic lymph nodes. The following parts are presented: indications of radiotherapy, total dose and fractionation, planning CT image acquisition, volume of interest delineation (target volumes and organs at risk) and margins, Intensity modulated radiotherapy planning and corresponding dose-volume constraints, and finally Image guided radiotherapy. PMID: 27516051 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 7, 2016 Category: Cancer & Oncology Authors: de Crevoisier R, Pommier P, Latorzeff I, Chapet O, Chauvet B, Hennequin C Tags: Cancer Radiother Source Type: research

[Radiotherapy for primary lung carcinoma].
Abstract Indication, doses, technique of radiotherapy and concomitant chemotherapy, for primary lung carcinoma are presented. The recommendations for delineation of the target volumes and organs at risk are detailed. PMID: 27516052 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 7, 2016 Category: Cancer & Oncology Authors: Giraud P, Lacornerie T, Mornex F Tags: Cancer Radiother Source Type: research

[Radiotherapy phase I trials' methodology: Features].
né N Abstract In clinical research, biostatistical methods allow the rigorous analysis of data collection and should be defined from the trial design to obtain the appropriate experimental approach. Thus, if the main purpose of phase I is to determine the dose to use during phase II, methodology should be finely adjusted to experimental treatment(s). Today, the methodology for chemotherapy and targeted therapy is well known. For radiotherapy and chemoradiotherapy phase I trials, the primary endpoint must reflect both effectiveness and potential treatment toxicities. Methodology should probably be complex to...
Source: Cancer Radiotherapie - July 19, 2016 Category: Cancer & Oncology Authors: Rivoirard R, Vallard A, Langrand-Escure J, Guy JB, Ben Mrad M, Yaoxiong X, Diao P, Méry B, Pigne G, Rancoule C, Magné N Tags: Cancer Radiother Source Type: research

[Frameless set-up with ExacTrac( ®) system for stereotactic radiotherapy of brain metastasis: Descriptive study from five French centres].
CONCLUSIONS: The practices of the different centres concerning the positioning protocols were rather homogeneous, in agreement with the literature data on ExacTrac(®) system's accuracy, as well as proposed fractionations. The systematic medical validation at the treatment station may, however, be questioned because of the waiting time between the doctor's call and validation itself and because of its usefulness; indeed, corrections by the radiation oncologist are very rare and in some centres, non-existent. PMID: 27449858 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 19, 2016 Category: Cancer & Oncology Authors: Ohnleiter T, Mahé MA, Biau J, Wdowczyk D, Clavier JB, Antoni D, Noël G Tags: Cancer Radiother Source Type: research

[Esthesioneuroblastoma: A single institution's experience and general literature review].
CONCLUSION: Our results are consistent with the literature. Because of the lack of prospective study and the low number of cases in the literature, each institution's experience is of the utmost important to improve standardised management of these tumours. PMID: 27449859 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 19, 2016 Category: Cancer & Oncology Authors: Lapierre A, Selmaji I, Samlali H, Brahmi T, Yossi S Tags: Cancer Radiother Source Type: research

[French organization of paediatric radiation treatment: Results of a survey conducted by the radiotherapy Committee of the French Society of Paediatric Cancers (SFCE)].
CONCLUSION: Paediatric radiation therapy is a specific activity requiring a dedicated management, both in human, organizational, medical and scientific aspects. PMID: 27421622 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 11, 2016 Category: Cancer & Oncology Authors: Demoor-Goldschmidt C, Claude L, Carrie C, Bolle S, Helfre S, Alapetite C, Jouin A, Padovani L, Ducassou A, Vigneron C, Le Prisé É, Huchet A, Stefan D, Kerr C, Nguyen TD, Truc G, Chapet S, Bondiau PY, Coche B, Muracciole X, Laprie A, Noël G, Leseur J, H Tags: Cancer Radiother Source Type: research

[Postoperative external beam radiotherapy for medullary thyroid carcinoma with high risk of locoregional relapse].
CONCLUSION: Maximal surgery followed by adjuvant external beam radiotherapy as a treatment for locally advanced medullary thyroid carcinoma provides a high rate of long-term locoregional control and overall survival with limited toxicity. Postoperative external beam radiotherapy should be considered when patients present features indicating a high risk of locoregional relapse. PMID: 27396902 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 4, 2016 Category: Cancer & Oncology Authors: Compagnon F, Zerdoud S, Rives M, Laprie A, Sarini J, Grunenwald S, Chaltiel L, Graff P Tags: Cancer Radiother Source Type: research

Feasibility evaluation of prone breast irradiation with the Sagittilt(©) system including residual-intrafractional error assessment.
CONCLUSION: The Sagittilt(©) system seems to be feasible for breast irradiation and well-tolerated by patients, acceptable to radiographers and reasonable in terms of treatment times. Set-up accuracy was comparable with other prone systems; residual errors need further investigations. PMID: 27396903 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 4, 2016 Category: Cancer & Oncology Authors: Lakosi F, Gulyban A, Ben-Mustapha Simoni S, Viet Nguyen P, Berkovic P, Noël M, Gourmet N, Coucke P Tags: Cancer Radiother Source Type: research

Correlation between radio-induced lymphocyte apoptosis measurements obtained from two French centres.
CONCLUSIONS: Since radio-induced lymphocyte apoptosis values, which predict tolerance to radiotherapy, could be assessed by two laboratories and showed a high level of robustness and consistency, we can suggest that this assay be extended to any laboratories that use the same technique. PMID: 27372557 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 28, 2016 Category: Cancer & Oncology Authors: Mirjolet C, Merlin JL, Dalban C, Maingon P, Azria D Tags: Cancer Radiother Source Type: research

Analysis of rare periparotid recurrence after parotid gland-sparing intensity-modulated radiotherapy for nasopharyngeal carcinoma.
CONCLUSION: Periparotid recurrences are rare after definitive IMRT for nasopharyngeal carcinoma. However, patients with ipsilateral retropharyngeal lymph nodes or level II nodal extracapsular spread on pretreatment MRI could be suspicious of metastatic periparotid nodules. Distant metastases were the main treatment failure despite a combination of several salvage treatment of periparotid recurrence. More effective chemotherapy should be explored. PMID: 27372558 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 28, 2016 Category: Cancer & Oncology Authors: Xu Y, Zhang M, Yue Q, Zong J, Lin J, Sun R, Qiu S, Lin S, Pan J Tags: Cancer Radiother Source Type: research

Comparison of dosimetric parameters and acute toxicity of intensity-modulated and three-dimensional radiotherapy in patients with cervix carcinoma: A randomized prospective study.
CONCLUSION: IMRT provide a good alternative for treatment of cervix carcinoma with lower acute gastrointestinal and acute genitourinary toxicity with similar target coverage compared to 3D conformal radiotherapy. PMID: 27368915 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 27, 2016 Category: Cancer & Oncology Authors: Naik A, Gurjar OP, Gupta KL, Singh K, Nag P, Bhandari V Tags: Cancer Radiother Source Type: research

Toxicity and efficacy of cetuximab associated with several modalities of IMRT for locally advanced head and neck cancer.
CONCLUSION: Patients treated with cetuximab had more cutaneous toxicities, but oral toxicity was similar between groups. The different IMRT modalities did not induce different toxicity profiles. PMID: 27345843 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 22, 2016 Category: Cancer & Oncology Authors: Bibault JE, Morelle M, Perrier L, Pommier P, Boisselier P, Coche-Dequéant B, Gallocher O, Alfonsi M, Bardet É, Rives M, Calugaru V, Chajon E, Noël G, Mecellem H, Pérol D, Dussart S, Giraud P Tags: Cancer Radiother Source Type: research

[Cardiovascular risks with prostate cancer hormonal treatment: rationale for a department of oncocardiology].
Abstract Prostate cancer, the most frequent cancer in man, is an adenocarcinoma sensible to chemical castration in more than 80% of cases due to its hormonal dependency. Androgen deprivation is the treatment for advanced cancer and can be associated with radiotherapy locally or in locally advanced situations. Multidisciplinary therapeutic choice depends on patient age and co-morbidities and clinical stage. The impact of hormonal treatment confers varied side effects and cardiovascular effects are now better known. Responsible mechanisms of this cardiotoxicity are at the same time direct but also indirect by metabo...
Source: Cancer Radiotherapie - June 21, 2016 Category: Cancer & Oncology Authors: Latorzeff I, Ploussard G, Guillotreau J, Jonca F, Labarthe P, Rollin G, Beauval JB, Pathak A Tags: Cancer Radiother Source Type: research

[Expected benefit of lymph node and seminal vesical dissection to decrease high-risk prostate cancer radiotherapy].
, de Crevoisier R Abstract PURPOSE: In case of pelvic lymph node and seminal vesicle dissection followed by prostate cancer intensity-modulated radiotherapy, the objective of the study was to evaluate the dosimetric benefit of reducing the target volume. PATIENTS AND METHODS: A total of 25 patients with high-risk prostate cancer had surgery first followed by intensity-modulated radiotherapy and androgen deprivation. Four treatment planning were simulated for each patient, based on two CT scans performed before and after surgery. The target volumes were: prostate-seminal vesicles-lymph nodes, prostate-lym...
Source: Cancer Radiotherapie - June 21, 2016 Category: Cancer & Oncology Authors: Colliaux J, Kharchi L, Vincendeau S, Simon A, Perdrieux M, Le Prisé É, Bellisant É, Castelli J, de Crevoisier R Tags: Cancer Radiother Source Type: research

[Practice evolution of hypofractionation in breast radiation therapy and medical impact].
This study focuses on fractionation practice evolution in a single centre, and analyses the economic impact of practice modification. MATERIAL AND METHODS: All prescriptions for invasive breast cancer between January 2010 and June 2014 were analyzed. Female patients 60 years or older, pN0 were considered for the economic study. Patients included in clinical trials or patient with high-grade tumours were excluded from the hypofractionation practice study, because physician could not choose fractionation. We used data from the Medical public health system to calculate cost per fraction and transporta...
Source: Cancer Radiotherapie - June 21, 2016 Category: Cancer & Oncology Authors: Dupin C, Vilotte F, Lagarde P, Petit A, Breton-Callu C Tags: Cancer Radiother Source Type: research

Breast-conserving treatment for ductal carcinoma in situ: Impact of boost and tamoxifen on local recurrences.
This study reports local recurrence rates in patients with ductal carcinoma in situ treated by breast-conserving surgery and whole breast irradiation with or without boost and/or tamoxifen and compares different therapeutic options in two European countries. PATIENTS AND METHODS: From 1998 to 2007, 819 patients with pure ductal carcinoma in situ were collected, both in France (266) and Italy (553). Median age was 56. All underwent breast-conserving surgery and whole breast irradiation; 391 (48%) received a boost (55% in France and 45% in Italy, P=0.017) and 173 (22.5%) tamoxifen (4.5% in France and 32% in Italy, P
Source: Cancer Radiotherapie - June 21, 2016 Category: Cancer & Oncology Authors: Cutuli B, Wiezzane N, Palumbo I, Barbieri P, Guenzi M, Huscher A, Borghesi S, Delva C, Iannone T, Vianello E, Rosetto ME, Aristei C Tags: Cancer Radiother Source Type: research

Preliminary results of the concurrent use of radiotherapy for bone metastases and trastuzumab emtansine in patients with HER2-positive metastatic breast cancer.
va YM PMID: 27342941 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 20, 2016 Category: Cancer & Oncology Authors: Géraud A, Xu HP, Beuzeboc P, Kirova YM Tags: Cancer Radiother Source Type: research

[Non-small cell lung cancer irradiation in elderly].
dry A Abstract People over the age of 65 are often excluded from participation in oncological clinical trials. However, more than half of patients diagnosed with non-small-cell lung cancer are older than 65 years. Any therapeutic strategy must be discussed in multidisciplinary meetings after adapted geriatric assessment. Patients who benefit from the comprehensive geriatric assessment (CGA) of Balducci and Extermann are those whose G8 screening tool score is less than or equal to 14. Age itself does not contraindicate a curative therapeutic approach. Stereotactic radiotherapy is an alternative to surgery for early...
Source: Cancer Radiotherapie - June 20, 2016 Category: Cancer & Oncology Authors: Dupic G, Bellière-Calandry A Tags: Cancer Radiother Source Type: research

[Hyperbaric oxygen and radiotherapy: From myth to reality].
te; N Abstract Worldwide, more than a million people receive each year a curative radiotherapy. While local control and overall survival are steadily increasing, 5 to 15% of patients still develop above grade 2 late toxicities. Late toxicities treatments are complex. Hyperbaric oxygenation was shown to induce revascularization and healing of injured tissues, but indications are still debated. Through a literature review, we summarized the hyperbaric oxygenation indications in radiation-induced late toxicities. We also studied the knowledge and practice of French local radiation therapists. It seems that hyper...
Source: Cancer Radiotherapie - June 20, 2016 Category: Cancer & Oncology Authors: Espenel S, Raffoux C, Vallard A, Garcia MA, Guy JB, Rancoule C, Ben Mrad M, Langrand-Escure J, Trone JC, Pigne G, Diao P, Magné N Tags: Cancer Radiother Source Type: research

Stereotactic body re-irradiation therapy for locally recurrent prostate cancer after external-beam radiation therapy: Initial report.
CONCLUSION: Stereotactic body re-irradiation therapy using CyberKnife(®) after failed external-beam radiation therapy showed favourable results in terms of in-field local and biochemical control. Toxicity was low and acceptable. Further prospective studies are needed to confirm these results to select patient and to evaluate the introduction of androgen-deprivation therapy. PMID: 27342944 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 20, 2016 Category: Cancer & Oncology Authors: Janoray G, Reynaud-Bougnoux A, Ruffier-Loubière A, Bernadou G, Pointreau Y, Calais G Tags: Cancer Radiother Source Type: research

[The concept of loss of chance: A major evolution in the definition of damage or how to prevent litigation for loss of chance?]
Abstract The concept of medical error in responsibility litigation was based until the past last years on a necessary direct and definite causal link between fault and injury. In France, since the 1960s and increasingly during the last decade, the idea of loss of chance arose, considered as a new and genuine prejudice (practically, a fixable damage); it became the subject of several legal precedents from the Cour de cassation and the Conseil d'État. Thus, plaintiffs may currently demand a compensation for a loss of chance even though a doubt exists on the causal link between the fault and the observed damag...
Source: Cancer Radiotherapie - June 20, 2016 Category: Cancer & Oncology Authors: Nguyen TD Tags: Cancer Radiother Source Type: research

[French experience in paediatric total body irradiation: A study from the radiotherapy committee of the Société française des cancers de l'enfant (SFCE)].
We present the results for total body irradiation in children, a specific technique of radiation treatment, which needs dedicated controls for this particular population. Of the 17 centres interviewed, 16 responded, and 13 practiced total body irradiation. Patients are positioned in lateral decubitus in 11 centres and supine/prone in two centres. Doses used for total body irradiation in myeloablative bone marrow transplantation are the same in all centres (12Gy); treatments are always fractionated. Lung shielding is positioned to limit the dose at an average of 8Gy with extremes ranging from 6 to 10Gy. ...
Source: Cancer Radiotherapie - June 20, 2016 Category: Cancer & Oncology Authors: Demoor-Goldschmidt C, Supiot S, Claude L, Carrie C, Mazeron R, Helfré S, Alapetite C, Jouin A, Coche B, Padovani L, Muracciole X, Bernier V, Vigneron C, Noël G, Leseur J, Le Prisé É, Stefan D, Habrand JL, Kerr C, Bondiau PY, Ruffier A, Chapet S, Mahé Tags: Cancer Radiother Source Type: research

[The enigma of the biological interpretation of the linear-quadratic model finally resolved? A summary for non-mathematicians].
Abstract The linear-quadratic (LQ) model is the only mathematical formula linking cellular survival and radiation dose that is sufficiently consensual to help radiation oncologists and radiobiologists in describing the radiation-induced events. However, this formula proposed in the 1970s and α and β parameters on which it is based remained without relevant biological meaning. From a collection of cutaneous fibroblasts with different radiosensitivity, built over 12 years by more than 50 French radiation oncologists, we recently pointed out that the ATM protein, major actor of the radiation resp...
Source: Cancer Radiotherapie - June 20, 2016 Category: Cancer & Oncology Authors: Bodgi L, Canet A, Granzotto A, Britel M, Puisieux A, Bourguignon M, Foray N Tags: Cancer Radiother Source Type: research

[Management of neuroendocrine prostate carcinoma: Literature review].
Abstract Neuroendocrine prostate carcinoma is a rare entity causing both diagnostic and therapeutic issues. There are basically four histological forms (adenocarcinoma with neuroendocrine differentiation, carcinoid tumors, small cell neuroendocrine carcinomas, large cell neuroendocrine carcinomas), which can be pure or mixed associated with prostatic carcinoma. There is no consensus on the management or the prognosis of these various tumor subtypes. We conducted a literature review aiming to determine the potential therapeutic implications. PMID: 27340027 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 19, 2016 Category: Cancer & Oncology Authors: Yossi S, Brahmi T, Enachescu C, Selmaji I, Lapierre A, Samlali H, Chapet O Tags: Cancer Radiother Source Type: research

High dose rate brachytherapy with customized applicators for malignant facial skin lesions.
CONCLUSION: High dose rate brachytherapy with customized applicators for facial skin and scalp lesions is efficient and safe. It is a good modality to treat complex lesions in patients unfit for invasive treatment. PMID: 27321412 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 15, 2016 Category: Cancer & Oncology Authors: Jumeau R, Renard-Oldrini S, Courrech F, Buchheit I, Oldrini G, Vogin G, Peiffert D Tags: Cancer Radiother Source Type: research