[Victor Despeignes (1866-1937): How a hygienist became the first radiation oncologist.]
Abstract Between the 4th and 23rd July 1896, Victor Despeignes has performed the first anticancer radiotherapy that has been validated by undeniable publications and practical facts. However, the events and the intellectual approach that led him to perform this unique treatment are misknown. This unpublished biography endeavours to better understand the work of Victor Despeignes who was, first of all, an hygienist physician. The conjunction of Pasteur's ideas, the discovery of X-rays and a probable technical help of the Lumière brothers led him to irradiate a cancerous tumour. The life of Victor Despeignes ...
Source: Cancer Radiotherapie - March 21, 2013 Category: Cancer & Oncology Authors: Foray N Tags: Cancer Radiother Source Type: research

Salivary glands radiotherapy to reduce sialorrhea in amyotrophic lateral sclerosis: Dose and energy.
Abstract PURPOSE: This retrospective study evaluated the effectiveness of salivary gland radiotherapy for reducing sialorrhea in patients with amyotrophic lateral sclerosis (ALS). PATIENTS AND METHODS: From August 2001 to February 2008, 21 patients with amyotrophic lateral sclerosis (six men, 15 women; mean age 61.2 years, range 39-81) received external beam radiotherapy for sialorrhea (evaluation by the ALS Functional Rating Scale). All patients had previously received pharmacological treatments with unsatisfactory results or side effects. The mean dose was 19.1Gy (range 3-48), delivered in five fractions (range ...
Source: Cancer Radiotherapie - March 18, 2013 Category: Cancer & Oncology Authors: Bourry N, Guy N, Achard JL, Verrelle P, Clavelou P, Lapeyre M Tags: Cancer Radiother Source Type: research

[Prospective monocentric study of the toxicity and the efficacy of concurrent trastuzumab to radiotherapy.]
CONCLUSIONS: Toxicities related to the association of trastuzumab to breast radiotherapy were mild. Further follow-up is warranted. PMID: 23499212 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 14, 2013 Category: Cancer & Oncology Authors: Jacob J, Belin L, Gobillion A, Daveau-Bergerault C, Dendale R, Beuzeboc P, Campana F, Bollet MA, Fourquet A, Kirova YM Tags: Cancer Radiother Source Type: research

[Brachytherapy for extremity soft tissue sarcomas.]
Abstract The standard of care of local treatment for extremities soft tissue sarcomas relies on conservative surgery combined with external beam radiotherapy. Brachytherapy can be realized instead of external beam radiotherapy in selected cases, or more often used as a boost dose on a limited volume on the area at major risk of relapse, especially if a microscopic positive resection is expected. In these cases, this combination allows to obtain the best local control rates published. Close interaction and communication between radiation oncologist and surgeon are mandatory at the time of implantation to limit the ...
Source: Cancer Radiotherapie - February 8, 2013 Category: Cancer & Oncology Authors: Delannes M, Thomas L, Brun T, David I, Ducassou A Tags: Cancer Radiother Source Type: research

[Brachytherapy training.]
ert D Abstract Treatment technique training needs theoretical and practical knowledge allowing proposing the right treatment for the right patient, but also allowing performing the technical gesture in the best conditions for an optimal result with a maximal security. The evolution of the brachytherapy techniques needs the set up of specific theoretical and practical training sessions. The present article focuses on the importance of the brachytherapy training as well as the different means currently available for the young radiation oncologist community for perfecting their education. National and international t...
Source: Cancer Radiotherapie - February 8, 2013 Category: Cancer & Oncology Authors: Hannoun-Lévi JM, Marchesi V, Peiffert D Tags: Cancer Radiother Source Type: research

[Brachytherapy for endometrial cancers.]
Abstract Surgery remains the cornerstone of the treatment for endometrial cancer, but brachytherapy plays a major role in the care of patients. In postoperative situations, brachytherapy is frequently indicated to prevent recurrences of the vaginal cuff. In case of medically inoperable patient, it can be, with or without external irradiation, an alternative treatment. In these two situations, techniques are radically different. PMID: 23375394 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 30, 2013 Category: Cancer & Oncology Authors: Charra-Brunaud C, Mazeron R Tags: Cancer Radiother Source Type: research

[A long survival after the treatment of a squamous cell carcinoma of the gallbladder.]
We report the case of a long survival after the treatment of a squamous cell carcinoma of the gallbladder. The patient is a 58-year-old man, who was treated by cholecystectomy, followed by postoperative radiotherapy of the tumour bed at a dose of 45Gy, combined with 5-fluoro-uracil chemotherapy. After 18 years, the patient is alive in complete remission. The end point of this work was to study the clinical and therapeutic characteristics of squamous cell carcinoma of the gallbladder and its prognosis through this case and a review of literature. PMID: 23352563 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 24, 2013 Category: Cancer & Oncology Authors: Bourmèche M, Ben Salah H, Kallel M, Beyrouti MI, Makni S, Boudawara T, Frikha M, Daoud J Tags: Cancer Radiother Source Type: research

[Brachytherapy in France: Past, present and what future?]
ert D PMID: 23352117 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 23, 2013 Category: Cancer & Oncology Authors: Hannoun-Lévi JM, Peiffert D Tags: Cancer Radiother Source Type: research

A simplified CT-based definition of the supraclavicular and infraclavicular nodal volumes in breast cancer.
CONCLUSIONS: Simplified CT-based atlas for delineation of the supra- and infraclavicular lymph nodes for locoregional irradiation of the breast on non-enhanced CT-scan, have been developed in this study. This atlas provides a consistent set of guidelines for delineating these volumes. PMID: 23333457 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 17, 2013 Category: Cancer & Oncology Authors: Atean I, Pointreau Y, Ouldamer L, Monghal C, Bougnoux A, Bera G, Barillot I Tags: Cancer Radiother Source Type: research

[Partial delegation to radiation therapists of the control by onboard imaging of patient positioning.]
, Lapeyre M Abstract PURPOSE: Daily set up of patients with prostate cancer using orthogonal kV/kV imaging and weekly set up control require 1h to 1h30 of off line revision by a radio-oncologist per day and per accelerator. The aim of this study was to evaluate the possibility to delegate this control to radiation therapists. MATERIEL AND METHODS: The files of 33 patients (including 13 with prostate cancer) treated from November 2010 to February 2011 on a Varian™ Clinac IX accelerator with an OBI™ system were evaluated. Radiation therapists made the daily kV/kV imaging. Radiation therapists made the on...
Source: Cancer Radiotherapie - January 17, 2013 Category: Cancer & Oncology Authors: Loos G, Biau J, Bellière A, Toledano I, Chillès A, Lapeyre M Tags: Cancer Radiother Source Type: research

[Localized Ewing sarcoma of the spine: A preliminary dose-escalation study comparing innovative radiation techniques in a single patient.]
CONCLUSION: With the most recent radiation therapy techniques, it becomes possible to deliver up to 70.4Gy in a favorable compartment in this sham patient. Unfavorable compartments can receive up to 59.2Gy. Definitive radiation therapy may be an interesting local treatment option to be validated in an early phase trial. PMID: 23333459 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 17, 2013 Category: Cancer & Oncology Authors: Vogin G, Biston MC, Marchesi V, Amessis M, De Marzi L, Lacroix F, Leroy A, Gassa F, Zefkili S, Helfre S Tags: Cancer Radiother Source Type: research

[Adjuvant treatment of keloid scars: Electrons or brachytherapy?]
CONCLUSION: Brachytherapy seems to provide better local control compared to electrontherapy, and should be proposed as first line treatment. However, electrontherapy is an interesting alternative in case of difficulty to realize brachytherapy. There is probably a dose effect: according to published data, 25 to 30Gy should at least be proposed. PMID: 23332126 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 14, 2013 Category: Cancer & Oncology Authors: Yossi S, Krhili S, Mesgouez-Nebout N, Vinchon-Petit S, Jadaud E, Tuchais C, Cellier P, Autret D, Rio E, Fernandez L, Poirier AL, Mahé MA, Paumier A Tags: Cancer Radiother Source Type: research

[Case report of EPPER Syndrome (eosinophilic polymorphic pruritic eruption associated with radiotherapy) in a patient treated against endometrial cancer.]
Abstract Acute and mainly late toxicity is a major concern for radiotherapists. Here, we describe a case of a generalized acute eruption due to radiation, having a superficial and deep perivascular lymphocytic infiltrate with numerous eosinophils found in skin biopsy: the EPPER syndrome (eosinophilic polymorphic pruritic eruption associated with radiotherapy). A patient who had endometrial cancer was treated first by surgery, then radiotherapy developed the day following the end of irradiation a generalized erythematous, pruriginous eruption (pelvis, trunk, lower and upper limbs, neck, face, ears). Different tests...
Source: Cancer Radiotherapie - January 3, 2013 Category: Cancer & Oncology Authors: Lam Cham Kee HX, Charra-Brunaud C, Cuny JF, Reigneau M, Vogin G, Peiffert D Tags: Cancer Radiother Source Type: research

[Identification of predictive biomarkers to radiotherapy outcome through proteomics approaches.]
Abstract The success of radiotherapy mainly depends on the total administered dose. This dose must be homogenously delivered onto the tumor and must preserve the surrounding healthy tissue. However, several patients are hypersensitive to ionizing radiations and may develop important radiation-induced early and late side effects. The prediction of these side effects remains currently impossible, involving to limit the given dose with the risk to decrease the therapeutic benefit for patients. Therefore, one of the major challenges in radiobiology is to accurately predict tumour radioresistance and to determine norma...
Source: Cancer Radiotherapie - December 31, 2012 Category: Cancer & Oncology Authors: Lacombe J, Mange A, Azria D, Solassol J Tags: Cancer Radiother Source Type: research

[Hypersensitivity to radiation therapy in a patient with tuberous sclerosis: Biological considerations about a clinical case.]
Abstract A 61-year-old man, with a tuberous sclerosis, experienced severe acute reactions during a concomitant chemoradiotherapy regimen after 22Gy and one cycle of 5-fluorouracil-cisplatinum. He was treated for a cervical squamous cell lymph node of unknown origin. Grade 3 mucitis and epitheliitis were observed only in the irradiated fields and required the end of the radiotherapy. Tuberous sclerosis is characterized by a loss of the TSC2 function, with a permanent activation of the mTOR pathway. Logically, some kind of "radioresistance" should be observed. Increased radiosensitivity is paradoxical. Thi...
Source: Cancer Radiotherapie - December 24, 2012 Category: Cancer & Oncology Authors: Duchemain B, Wong S, Baruch-Hennequin V, Rivera S, Quero L, Hennequin C Tags: Cancer Radiother Source Type: research

[Esophageal cancer: Outcome according to therapeutic strategy.]
CONCLUSION: More than one-third relapse is local. Locoregional control is better with high dose chemoradiotherapy. In this study, surgery performed in selected patients only, improved locoregional control, relapse-free disease and overall survival. PMID: 23270680 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 24, 2012 Category: Cancer & Oncology Authors: Rousseau D, Capitain O, Denis F, Girault S, Poirier AL, Paumier A, Cellier P, Hamy A, Mahé MA, Mesgouez-Nebout N Tags: Cancer Radiother Source Type: research

[Intensity modulated radiotherapy for head and neck cancers: Ethics and patients selection.]
CONCLUSION: To help in the choice of the patients receiving an IMRT in a crisis situation, we proposed a hierarchical organization of selection criteria: complex volumes close to critical organs at risk, localization with high risk of xerostomia, long life expectancy and postoperative delay constraints. PMID: 23219137 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 3, 2012 Category: Cancer & Oncology Authors: Renard-Oldrini S, Zielinski A, Mecellem H, Graff P, Marchesi V, Peiffert D Tags: Cancer Radiother Source Type: research

[Dropped Head Syndrome after whiplash injury in a patient treated for a Hodgkin's lymphoma by mantle field radiotherapy.]
oul E Abstract The authors report a case of Dropped Head Syndrome with an unusually rapid onset after an accident in a patient with a history of Hodgkin's lymphoma cured by chemotherapy and mantle field radiotherapy and compare this case to the rare published cases of chronic Dropped Head Syndrome occurring after this type of treatment. A 56-year-old man was treated at the age 36 years for supra-diaphragmatic Hodgkin's lymphoma by chemotherapy and mantle field radiotherapy according to a standard technique and standard doses (40Gy, 20 fractions, 27 days). Seventeen years after the end of treatment, he experienced ...
Source: Cancer Radiotherapie - December 3, 2012 Category: Cancer & Oncology Authors: Schlienger M, Ferroir JP, Huguet F, Deluen F, Pène F, Marseguerra R, Touboul E Tags: Cancer Radiother Source Type: research

[Prostate-specific antigen bounce after permanent seed prostate brachytherapy: A literature review].
Abstract Permanent seeds brachytherapy is a standard in the treatment of localized prostate cancer. Follow-up of patients treated with brachytherapy relies on monitoring the concentration of PSA. It is supposed to decrease steadily to a nadir after several years. This decrease could be disrupted by transient and benign elevation of the marker, sometimes mimicking genuine biochemical relapses, sources of anxiety for patients or even unnecessary tests. While the precise mechanisms of this phenomenon are poorly understood, their characteristics have been, however, extensively studied. This work aims to make an update...
Source: Cancer Radiotherapie - December 1, 2012 Category: Cancer & Oncology Authors: Mazeron R, Bajard A, Pommier P Tags: Cancer Radiother Source Type: research

[Gated radiotherapy in breast cancer].
Abstract Postoperative radiotherapy is a cornerstone of the local treatment in breast cancer. It has been proved with high level of evidence that it decreases local relapse and improves survival of patients. However, radiotherapy comes with healthy tissue toxicity, heart and lung in particular. With constant improvement of radiation techniques, several methods have been developed to decrease the dose to the heart and the lungs. Sometimes, respiratory maneuvers can help, due to patient's anatomy: the radiotherapy is gated with patient's breath. The Deep Inspiration Breath Hold technique is the most popular and ther...
Source: Cancer Radiotherapie - December 1, 2012 Category: Cancer & Oncology Authors: Maroun P, Jacob J, Roberti E, Bourgier C, Heymann S Tags: Cancer Radiother Source Type: research

[Evidences in multidisciplinary management of rectal cancer].
ini V Abstract In the last 10 years, a number of important European randomized published studies investigated the optimal management of rectal cancer. In order to define an evidence-based approach of the clinical practice based, an international consensus conference was organized in Italy under the endorsement of European Society of Medical Oncology (ESMO), European Society of Surgical Oncology (ESSO) and European Society of Therapeutic Radiation Oncology (ESTRO). The aim of this article is to present highlights of multidisciplinary rectal cancer management and to compare the conclusions of the international confe...
Source: Cancer Radiotherapie - December 1, 2012 Category: Cancer & Oncology Authors: De Bari B, Bosset JF, Gérard JP, Maingon P, Valentini V Tags: Cancer Radiother Source Type: research

[Functional modeling for risk analysis in radiotherapy].
CONCLUSION: Modeling approach derived from engineering may be used for functional modeling for risk analysis in radiotherapy. PMID: 23182502 [PubMed - in process] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 1, 2012 Category: Cancer & Oncology Authors: Reitz A, Pétin JF, Levrat E, Noel A, Aigle D, Peiffert D, Graff P Tags: Cancer Radiother Source Type: research

[Is adaptive radiation therapy for uterine cervix carcinoma mandatory?].
CONCLUSION: As a whole, adaptive therapy does not seem mandatory in this population of stages IB2-IIB cancers. A complementary study on more advanced stages is however necessary. PMID: 23182503 [PubMed - in process] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - December 1, 2012 Category: Cancer & Oncology Authors: Le Tinier F, Reynaert N, Castelain B, Lartigau E, Lacornerie T, Nickers P Tags: Cancer Radiother Source Type: research