Five-fraction radiotherapy for breast cancer
Cancer Radiother. 2023 Aug 1:S1278-3218(23)00146-4. doi: 10.1016/j.canrad.2023.07.004. Online ahead of print.ABSTRACTExtreme hypofractionation in adjuvant breast radiotherapy currently generates a lot of interest. We propose here a synthesis of hypofractionation trials and present the DESTHE COL and DESTHE GR projects, encouraged by the French National Cancer Institute (INCa), which experiment care pathways in order to deploy effective strategies to de-escalate the therapeutics and to reduce sequelae after cancer treatment.PMID:37537026 | DOI:10.1016/j.canrad.2023.07.004 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 3, 2023 Category: Cancer & Oncology Authors: M Dworczak G Bielinyte A Coutte X Mirabel É Lartigau P Lemoine S Rivera D Pasquier Source Type: research
Stereotactic Body Radiation Therapy for less than 3cm (stage I) and 5cm (stage II) inoperable lung tumors: 10 years experience of Montpellier Cancer Institute
CONCLUSION: SBRT is associated with an excellent overall survival and a high rate of local control for less than 3cm (stage I) and 5cm (stage II) lung tumors but a low rate of toxicities. For these patients with many comorbidities, BED over 150Gy seems to be associated with a better loco-regional free survival, while cause of death is often other than lung cancer.PMID:37537027 | DOI:10.1016/j.canrad.2023.05.002 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 3, 2023 Category: Cancer & Oncology Authors: A Marguerit D Azria O Riou S Demontoy S Thezenas P Boisselier Source Type: research
Voxel-wise analysis: A powerful tool to predict radio-induced toxicity and potentially perform personalised planning in radiotherapy
Cancer Radiother. 2023 Jul 28:S1278-3218(23)00139-7. doi: 10.1016/j.canrad.2023.06.024. Online ahead of print.ABSTRACTDose - volume histograms have been historically used to study the relationship between the planned radiation dose and healthy tissue damage. However, this approach considers neither spatial information nor heterogenous radiosensitivity within organs at risk, depending on the tissue. Recently, voxel-wise analyses have emerged in the literature as powerful tools to fully exploit three-dimensional information from the planned dose distribution. They allow to identify anatomical subregions of one or several org...
Source: Cancer Radiotherapie - July 30, 2023 Category: Cancer & Oncology Authors: C Sosa-Marrero O Acosta D Pasquier J Thariat G Delpon C Fiorino T Rancatti O Malard N Foray R de Crevoisier Source Type: research
Real world data in radiotherapy: A data farming project by Unitrad
Cancer Radiother. 2023 Jul 28:S1278-3218(23)00128-2. doi: 10.1016/j.canrad.2023.06.016. Online ahead of print.ABSTRACTThe aim of the data farming project by the Unitrad group is to produce and use large quantities of structured real-life data throughout radiotherapy treatment. Starting in 2016, target real world data were selected at expert consensus conferences and regularly updated, then captured in MOSAIQ© as the patient was treated. For each partner institution, the data was then stored in a relational database, then extracted and used by researchers to create real world knowledge. This production was carried out in a...
Source: Cancer Radiotherapie - July 30, 2023 Category: Cancer & Oncology Authors: S Guihard M Piot I Issoufaly P Giraud M Bruand J-C Faivre R Eug ène X Liem D Pasquier A Lamrani-Ghaouti Y Ghannam A Ruffier P Guilbert A Larnaudie J Thariat S Rivera J-B Clavier Source Type: research
Voxel-wise analysis: A powerful tool to predict radio-induced toxicity and potentially perform personalised planning in radiotherapy
Cancer Radiother. 2023 Jul 28:S1278-3218(23)00139-7. doi: 10.1016/j.canrad.2023.06.024. Online ahead of print.ABSTRACTDose - volume histograms have been historically used to study the relationship between the planned radiation dose and healthy tissue damage. However, this approach considers neither spatial information nor heterogenous radiosensitivity within organs at risk, depending on the tissue. Recently, voxel-wise analyses have emerged in the literature as powerful tools to fully exploit three-dimensional information from the planned dose distribution. They allow to identify anatomical subregions of one or several org...
Source: Cancer Radiotherapie - July 30, 2023 Category: Cancer & Oncology Authors: C Sosa-Marrero O Acosta D Pasquier J Thariat G Delpon C Fiorino T Rancatti O Malard N Foray R de Crevoisier Source Type: research
Real world data in radiotherapy: A data farming project by Unitrad
Cancer Radiother. 2023 Jul 28:S1278-3218(23)00128-2. doi: 10.1016/j.canrad.2023.06.016. Online ahead of print.ABSTRACTThe aim of the data farming project by the Unitrad group is to produce and use large quantities of structured real-life data throughout radiotherapy treatment. Starting in 2016, target real world data were selected at expert consensus conferences and regularly updated, then captured in MOSAIQ© as the patient was treated. For each partner institution, the data was then stored in a relational database, then extracted and used by researchers to create real world knowledge. This production was carried out in a...
Source: Cancer Radiotherapie - July 30, 2023 Category: Cancer & Oncology Authors: S Guihard M Piot I Issoufaly P Giraud M Bruand J-C Faivre R Eug ène X Liem D Pasquier A Lamrani-Ghaouti Y Ghannam A Ruffier P Guilbert A Larnaudie J Thariat S Rivera J-B Clavier Source Type: research
Voxel-wise analysis: A powerful tool to predict radio-induced toxicity and potentially perform personalised planning in radiotherapy
Cancer Radiother. 2023 Jul 28:S1278-3218(23)00139-7. doi: 10.1016/j.canrad.2023.06.024. Online ahead of print.ABSTRACTDose - volume histograms have been historically used to study the relationship between the planned radiation dose and healthy tissue damage. However, this approach considers neither spatial information nor heterogenous radiosensitivity within organs at risk, depending on the tissue. Recently, voxel-wise analyses have emerged in the literature as powerful tools to fully exploit three-dimensional information from the planned dose distribution. They allow to identify anatomical subregions of one or several org...
Source: Cancer Radiotherapie - July 30, 2023 Category: Cancer & Oncology Authors: C Sosa-Marrero O Acosta D Pasquier J Thariat G Delpon C Fiorino T Rancatti O Malard N Foray R de Crevoisier Source Type: research
Real world data in radiotherapy: A data farming project by Unitrad
Cancer Radiother. 2023 Jul 28:S1278-3218(23)00128-2. doi: 10.1016/j.canrad.2023.06.016. Online ahead of print.ABSTRACTThe aim of the data farming project by the Unitrad group is to produce and use large quantities of structured real-life data throughout radiotherapy treatment. Starting in 2016, target real world data were selected at expert consensus conferences and regularly updated, then captured in MOSAIQ© as the patient was treated. For each partner institution, the data was then stored in a relational database, then extracted and used by researchers to create real world knowledge. This production was carried out in a...
Source: Cancer Radiotherapie - July 30, 2023 Category: Cancer & Oncology Authors: S Guihard M Piot I Issoufaly P Giraud M Bruand J-C Faivre R Eug ène X Liem D Pasquier A Lamrani-Ghaouti Y Ghannam A Ruffier P Guilbert A Larnaudie J Thariat S Rivera J-B Clavier Source Type: research
Interactions between vascular endothelium and immune cells: A key control point of radiation-induced digestive lesions
Cancer Radiother. 2023 Jul 27:S1278-3218(23)00126-9. doi: 10.1016/j.canrad.2023.06.013. Online ahead of print.ABSTRACTRadiation-induced toxicity of the digestive tract is a major clinical concern as many cancer survivors have received radiotherapy for tumours of the abdominopelvic area. The coordination and orchestration of a tissue's response to stress depend not only on the phenotype of the cells that make up the tissue but also on cell-cell interactions. The digestive system, i.e., the intestine/colon/rectum, is made up of a range of different cell populations: epithelial cells, stromal cells, i.e. endothelial cells and...
Source: Cancer Radiotherapie - July 29, 2023 Category: Cancer & Oncology Authors: M Mondini O Guipaud A Fran çois N Mathieu É Deutsch F Milliat Source Type: research
Stereotactic radiotherapy for ultracentral lung tumours
Cancer Radiother. 2023 Jul 27:S1278-3218(23)00130-0. doi: 10.1016/j.canrad.2023.06.021. Online ahead of print.ABSTRACTUltracentral (UC) lung lesions are generally defined by the presence of the tumour or the Planning Target Volume (PTV) abutting proximal bronchial tree (PBT) or the esophagus. Initial reports rose awareness regarding the potential toxicity of stereotactic body radiotherapy (SBRT) when delivered to UC lesions. Major concerns include necrosis, stenosis, and bleeding of the PBT. Technological improvements now enable the delivery of more accurate treatments, possibly redefining the historical "no-fly zone". In ...
Source: Cancer Radiotherapie - July 29, 2023 Category: Cancer & Oncology Authors: V Bourbonne S Thureau O Pradier D Antoni F Lucia Source Type: research
Interactions between vascular endothelium and immune cells: A key control point of radiation-induced digestive lesions
Cancer Radiother. 2023 Jul 27:S1278-3218(23)00126-9. doi: 10.1016/j.canrad.2023.06.013. Online ahead of print.ABSTRACTRadiation-induced toxicity of the digestive tract is a major clinical concern as many cancer survivors have received radiotherapy for tumours of the abdominopelvic area. The coordination and orchestration of a tissue's response to stress depend not only on the phenotype of the cells that make up the tissue but also on cell-cell interactions. The digestive system, i.e., the intestine/colon/rectum, is made up of a range of different cell populations: epithelial cells, stromal cells, i.e. endothelial cells and...
Source: Cancer Radiotherapie - July 29, 2023 Category: Cancer & Oncology Authors: M Mondini O Guipaud A Fran çois N Mathieu É Deutsch F Milliat Source Type: research
Stereotactic radiotherapy for ultracentral lung tumours
Cancer Radiother. 2023 Jul 27:S1278-3218(23)00130-0. doi: 10.1016/j.canrad.2023.06.021. Online ahead of print.ABSTRACTUltracentral (UC) lung lesions are generally defined by the presence of the tumour or the Planning Target Volume (PTV) abutting proximal bronchial tree (PBT) or the esophagus. Initial reports rose awareness regarding the potential toxicity of stereotactic body radiotherapy (SBRT) when delivered to UC lesions. Major concerns include necrosis, stenosis, and bleeding of the PBT. Technological improvements now enable the delivery of more accurate treatments, possibly redefining the historical "no-fly zone". In ...
Source: Cancer Radiotherapie - July 29, 2023 Category: Cancer & Oncology Authors: V Bourbonne S Thureau O Pradier D Antoni F Lucia Source Type: research
The morbidity and mortality review meetings in radiotherapy departments: Procedure, implementation and prospects of the "Proust" French national project
Cancer Radiother. 2023 Jul 26:S1278-3218(23)00132-4. doi: 10.1016/j.canrad.2023.06.018. Online ahead of print.ABSTRACTRadiation-induced acute and late toxicity depends on several parameters. The type, severity and duration of morbidity are mainly related to irradiated volume, total dose and its fractionation and the intrinsic radiosensitivity of the patients. The follow-up of these toxicities is essential. However, unlike many specialties, morbidity and mortality reviews procedures are not developed as part of quality governance programs in radiation therapy departments for the monitoring of toxicity which sometimes hinder...
Source: Cancer Radiotherapie - July 28, 2023 Category: Cancer & Oncology Authors: Y Belkacemi K Debbi C Besnard N Grellier G Fonteneau L Colson-Durand D Lerouge C Durdux F Campana P Pons I Flandin D Pasquier R de Crevoisier T Wachter S Thureau G No ël L Conzague-Casabianca A Petit S Supiot D Azria Source Type: research
Place of radiotherapy for treatment of metastatic cervical, vaginal and endometrial uterine cancer
Cancer Radiother. 2023 Jul 26:S1278-3218(23)00125-7. doi: 10.1016/j.canrad.2023.06.012. Online ahead of print.ABSTRACTBeyond classical palliative-intent irradiation schemes, there are increasing data suggesting a benefit for intensive locoregional treatments in metastatic gynecological cancers. Such approach aims at avoiding local symptoms related to tumor progression, but may also improve survival outcome by shrinking tumor burden to a microscopic state. This strategy is rarely considered upfront (in highly selected patients with very limited oligometastatic disease), but rather after systemic treatment. In case of tumor ...
Source: Cancer Radiotherapie - July 28, 2023 Category: Cancer & Oncology Authors: A Escande J Leblanc J-M Hannoun-Levi S Renard A Ducassou C Hennequin C Chargari Source Type: research
The morbidity and mortality review meetings in radiotherapy departments: Procedure, implementation and prospects of the "Proust" French national project
Cancer Radiother. 2023 Jul 26:S1278-3218(23)00132-4. doi: 10.1016/j.canrad.2023.06.018. Online ahead of print.ABSTRACTRadiation-induced acute and late toxicity depends on several parameters. The type, severity and duration of morbidity are mainly related to irradiated volume, total dose and its fractionation and the intrinsic radiosensitivity of the patients. The follow-up of these toxicities is essential. However, unlike many specialties, morbidity and mortality reviews procedures are not developed as part of quality governance programs in radiation therapy departments for the monitoring of toxicity which sometimes hinder...
Source: Cancer Radiotherapie - July 28, 2023 Category: Cancer & Oncology Authors: Y Belkacemi K Debbi C Besnard N Grellier G Fonteneau L Colson-Durand D Lerouge C Durdux F Campana P Pons I Flandin D Pasquier R de Crevoisier T Wachter S Thureau G No ël L Conzague-Casabianca A Petit S Supiot D Azria Source Type: research
