[Audits of the quality management system and safety in radiotherapy: Lessons learned and future prospects].
We present the results of the first audits conducted, and the results of a survey on the perception of quality at national level. PMID: 27614502 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Leroy E, Marque A Tags: Cancer Radiother Source Type: research

[Interest of positioning control in onboard imaging and its delegation to the therapists].
lli J Abstract The delegation of the on board imaging position control, from the radiation oncologist to the therapist, is justified by the generalization of the image-guided radiotherapy techniques which are particularly time consuming. This delegation is however partial. Indeed, the validation of the position by the therapist can be clearly performed when the registration is based on bony landmark or fiducial. The radiation oncologist needs however to make the validation in case of large target displacement, in more complex soft tissue-based registration, and in case of stereotactic body radiation therapy. Moreo...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: de Crevoisier R, Duvergé L, Hulot C, Chauvet B, Henry O, Bouvet C, Castelli J Tags: Cancer Radiother Source Type: research

[What is the role of intraoperative radiotherapy in breast cancer treatment?]
Abstract Breast-conserving surgery followed by whole breast postoperative irradiation is considered to be the current standard treatment for patients with early stage breast cancer. It allows an excellent local tumour control with 6% of local recurrence. Over the last years, partial breast radiotherapy has been developed to reduce treatment volume and duration. Intraoperative radiotherapy is one of the techniques. It offers an excellent delineation of the tumour bed and high normal tissue sparing. This purpose of this review is to describe the different intraoperative radiotherapy techniques available, to assess t...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Aumont M Tags: Cancer Radiother Source Type: research

[Position-checking by imaging embarked there tomotherapy and the delegation to the radiology technician].
e;e M Abstract Tomotherapy is a technique of IMRT and IGRT using a linear accelerator and a helical CT-scanner. To reach this targeting of precision, the repositioning of the patient is essential. The use of a contention adapted according to the location of the disease and the morphology of the patient is necessary for the safety of this one and the treatment. Once the patient positioned on the reference table, technicians of imager's team check by the acquisition of helical imagery with the reference CT-scanner the position of the patient, the zone of the PTV and healthy organs in the protected surroundings. At f...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Autret A, Choupeaux D, Le Mée M Tags: Cancer Radiother Source Type: research

[Margin determination from clinical to planning target volume for lung cancer treated with conformal or intensity-modulated irradiation].
Abstract Technological progress in radiotherapy enables more precision for treatment planning and delivery. The margin determination between the clinical target volume and the planning target volumes stem from the estimation of geometric uncertainties of the tumour localization into the radiation beam. The inner motion complexity of lung tumours has led to the use of 4D computed tomography and nurtures specific dosimetric concerns. Few strategies consisting in integrating tumour motion allow margin reduction regarding inner movements. The patient immobilization and onboard imagery improvement decrease the setup un...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Berthelot K, Thureau S, Giraud P Tags: Cancer Radiother Source Type: research

[Intensity-modulated radiotherapy of head and neck cancers: Dose effects on the ocular, orbital and eyelid structures].
Abstract Radiation-induced damage of ocular, orbital and eyelid structures are mainly reported for the optic nerve, retina, lens and lacrimal gland. Dose-volume relationships are, however, inaccurate due to the small volume of most of the organs at risk involved and limited ability of irradiation techniques to spare these structures in the pre-IMRT (intensity-modulated radiation therapy) era. The ability of newest radiation techniques including IMRT and proton therapy to generate steep dose gradients may yield more accurate models in the future. Some toxicities are severe and irreversible, leading to vision loss, ...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Thariat J, Racadot S, Pointreau Y, Boisselier P, Grange JD, Graff P, Weber DC Tags: Cancer Radiother Source Type: research

[Indications and results for protontherapy in cancer treatments].
un-Lévi JM Abstract Purpose was to summarize results for proton therapy in cancer treatment. A systematic review has been done by selecting studies on the website www.pubmed.com (Medline) and using the following keywords: proton therapy, radiation therapy, cancer, chordoma, chondrosarcoma, uveal melanoma, retinoblastoma, meningioma, glioma, neurinoma, pituitary adenoma, medulloblastoma, ependymoma, craniopharyngioma and nasal cavity. There are several retrospective studies reporting results for proton therapy in cancer treatments in the following indications: ocular tumors, nasal tumors, skull-based tumors,...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Doyen J, Bondiau PY, Benezery K, Thariat J, Vidal M, Gérard A, Hérault J, Carrie C, Hannoun-Lévi JM Tags: Cancer Radiother Source Type: research

[Radiotherapy for localized gastric and orbital MALT lymphomas].
ieblemont C Abstract Primary gastric and orbital MALT lymphomas are both low grade (indolent) B-cell non-Hodgkin's lymphomas. Traditionally, these tumors are radiosensitive and have a good prognosis. In localized orbital and stages IE-IIE gastric MALT lymphomas without Helicobacter pylori infection or in case of persistent H. pylori infection after eradication therapy, several retrospective studies have shown that radiotherapy was an effective and well-tolerated treatment. PMID: 27614509 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Quéro L, Hennequin C, Amorim S, Guillerm S, Ruskoné-Fourmestraux A, Thieblemont C Tags: Cancer Radiother Source Type: research

[Technical aspects of protontherapy: Setup, equipment and radioprotection].
Abstract The number of protontherapy facilities is still increasing rapidly with more than 30 ongoing projects and close to 60 currently under operation. Although the technology is now validated and robust, a proton facility cannot be considered as a standard radiation therapy equipment: its constraints in terms of building, services, project management are of paramount impact at the level of the hospital. Therefore, a protontherapy project must be carefully considered and prepared, which is mandatory for further fluid and efficient clinical operation. PMID: 27614510 [PubMed - as supplied by publish...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Ferrand R Tags: Cancer Radiother Source Type: research

[Stereotactic body radiation therapy for spinal metastases].
cute; Abstract After the liver and lungs, bones are the third most common sites of cancer metastasis. Palliative radiotherapy for secondary bone tumours helps relieve pain, improve the quality of life and reduce the risk of fractures. Stereotactic body radiotherapy can deliver high radiation doses with very tight margins, which has significant advantages when treating tumours close to the spinal cord. Strict quality control is essential as dose gradient at the edge of the spinal cord is important. Optimal schedule is not defined. A range of dose-fractionation schedules have been used. Pain relief and local control...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Pasquier D, Martinage G, Mirabel X, Lacornerie T, Makhloufi S, Faivre JC, Thureau S, Lartigau É Tags: Cancer Radiother Source Type: research

[Role of surgery in the management of vertebral metastases. General revue].
Abstract The spine is the most common site of skeletal metastases. Treatment decisions for patients with spinal metastases can be challenging and greatly depend on survival prognosis. Surgery remains a valuable weapon in the therapeutic arsenal. A review of the literature describing the role of surgery, the various surgical approaches and the prognostic scores available for the management of spinal metastases was performed and summarized. Surgery for spinal metastases has 3 main objectives: management of pain, achievement of mechanical stability and preservation or restoration of neurological function. A vari...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Abi Lahoud G, Abi Jaoude S Tags: Cancer Radiother Source Type: research

CTV to PTV in cervical cancer: From static margins to adaptive radiotherapy.
The objectives of this review were: (a) to present the evidence available for the determination of CTV-PTV margin for uterine cancers; (b) to highlight the impact of these margins in the context of adaptive radiotherapy; and (c) to discuss the role of the PTV concept in intracavitary brachytherapy. PMID: 27614513 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Sun R, Mazeron R, Chargari C, Barillot I Tags: Cancer Radiother Source Type: research

[Role of functional imaging in the definition of target volumes for lung cancer radiotherapy].
Abstract Functional imaging with positron emission tomography (PET) is interesting to optimize lung radiotherapy planning, and probably to deliver a heterogeneous dose or adapt the radiation dose during treatment. Only fluorodeoxyglucose (FDG) PET-computed tomography (CT) is validated for staging lung cancer and planning radiotherapy. The optimal segmentation methods remain to be defined as well as the interest of "dose painting" from pre-treatment PET (metabolism: FDG) or hypoxia (fluoromisonidazole: FMISO) and the interest of replanning based on pertherapeutic PET. PMID: 27614514 [PubMed - as supp...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Thureau S, Hapdey S, Vera P Tags: Cancer Radiother Source Type: research

[Clinical to planning target volume margins in prostate cancer radiotherapy].
ier R Abstract The knowledge of inter- and intrafraction motion and deformations of the intrapelvic target volumes (prostate, seminal vesicles, prostatectomy bed and lymph nodes) as well as the main organs at risk (bladder and rectum) allow to define rational clinical to planning target volume margins, depending on the different radiotherapy techniques and their uncertainties. In case of image-guided radiotherapy, prostate margins and seminal vesicles margins can be between 5 and 10mm. The margins around the prostatectomy bed vary from 10 to 15mm and those around the lymph node clinical target volume bet...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Ramiandrisoa F, Duvergé L, Castelli J, Nguyen TD, Servagi-Vernat S, de Crevoisier R Tags: Cancer Radiother Source Type: research

[Hypofractionated whole breast irradiation (WBRT): Results and indications].
Abstract Breast irradiation after breast-conserving surgery is essential for maximizing local control and overall survival. The increase of breast cancer (BC) incidence, constraints of classical five weeks (w) radiation regimens and scarcity of radiotherapy units have led to test short hypofractionated WBRT schemes. One pilot study and three prospective randomized trials have tested various hypofractionated regimens of WBRT. About 7000 patients were included and follow-up ranged from 5 to 12 years. The conclusion of these trials is similar, showing local control and toxicity equivalent to these of the st...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Cutuli B Tags: Cancer Radiother Source Type: research

[Role of radiotherapy in the treatment of NK/T-cell nasal type and primary cerebral lymphomas].
Abstract The head and neck are common sites for extranodal non-Hodgkin lymphomas. Radiotherapy plays an important role in the treatment of low-grade lymphomas, with curative or palliative intent. In the case of high-grade lymphomas, its combination with chemotherapy is debated. Its role is however undeniable in two specific entities: NK/T-cell lymphoma NK/T nasal type, and primary central nervous system lymphomas, which are the subject of this review. PMID: 27614517 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Boros A, Michot JM, Hoang-Xuan K, Mazeron R Tags: Cancer Radiother Source Type: research

[Computed tomography imaging of non-small cell lung cancer].
Abstract Computed tomography (CT) plays a key role in the initial evaluation of non-small cell lung cancer. It allows initial staging and helps targeting lesions for pathological analysis. The aim of initial imaging work-up is to differentiate between localized disease, eligible to a local treatment, and advanced disease requiring medical treatment. CT is very useful for the assessment of local extension but is less accurate than positron emission tomography (PET)-CT for the assessment of lymphatic and metastatic spread. However, initial staging should include CT examination of the brain and upper abdomen, and PET...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Chassagnon G, Bennani S, Revel MP Tags: Cancer Radiother Source Type: research

[Intensity modulated radiotherapy for head and neck cancer, dose constraint for normal tissue: Cochlea vestibular apparatus and brainstem].
Abstract Modern techniques such as intensity modulated radiation therapy (IMRT) have been proven to significantly decrease the dose delivered to the cochleovestibular apparatus, limiting consecutive toxicity especially for sensorineural hearing loss. However, recent data still report a 42% rate of radio-induced hypoacusia underscoring the need to protect the cochleovestibular apparatus. Due to the small size of the cochlea, a precise dose-volume analysis could not be performed, and recommendations only refer to the mean dose. Confusing factors such as age, concomitant chemotherapy, primary site and tumor stage sho...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Guimas V, Thariat J, Graff-Cailleau P, Boisselier P, Pointreau Y, Pommier P, Montbarbon X, Laude C, Racadot S Tags: Cancer Radiother Source Type: research

[Establishing margins from CTV to PTV in breast cancer treatment].
Abstract The benefit of postoperative radiotherapy for breast cancer both in terms of local control and overall survival is widely acknowledged. Today, technological advances in simulation imaging and positioning control enable the definition of new margins from CTV to PTV. Improvements in mathematical modeling of random and systematic errors impact the treatment plans. However, there is no universal absolute value to consistently determine the margins from CTV to PTV. It is down to each centre to assess and correct as much as possible uncertainties due to positioning and internal movements depending on techniques...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Cabanne A, Schick U, Pradier O, Rivera S Tags: Cancer Radiother Source Type: research

[Radiotherapy and targeted therapy/immunotherapy].
Abstract Thanks to recent advances achieved in oncologic systemic and local ablative treatment, the treatments become more and more efficient in term of local control and overall survival. Thus, the targeted therapies, immunotherapy or stereotactic radiotherapy have modified the management of patients, especially in case of oligometastatic disease. Many questions are raised by these innovations, particularly the diagnosis and management of new side effects or that of the combination of these different treatments, depending on the type of primary tumor. Fundamental data are available, while clinical data are still ...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Antoni D, Bockel S, Deutsch E, Mornex F Tags: Cancer Radiother Source Type: research

[Radiotherapy for small cell lung carcinoma].
Abstract Radiotherapy for small cell lung carcinoma has known significant improvements over the past 10 years especially through routine use of PET-CT in the initial work-up and contouring before treatment. Prophylactic cranial irradiation remains a standard of care for locally advanced disease and is a subject of controversy for metastatic disease. A new indication for thoracic radiotherapy may soon arise for metastatic disease, still confirmation studies are ongoing. PMID: 27614522 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Pourel N Tags: Cancer Radiother Source Type: research

[Methodological aspect, application and evaluation of the delegation of tasks of the recalage of images].
Abstract Application and evaluation of the delegation of tasks of the recalage of images, the example of the authorization of the manipulators of the unity (unit) of radiotherapy of the Hospital center of Quimper. PMID: 27614523 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Ponsard N Tags: Cancer Radiother Source Type: research

[Intensity-modulated radiotherapy for head and neck cancer. Dose constraint for salivary gland and mandible].
aff P Abstract Intensity-modulated radiation therapy (IMRT) is the gold standard for head and neck irradiation. It allows better protection to the organs at risk such as salivary glands and mandible, and can reduce the frequency of xerostomia, trismus and osteoradionecrosis. At the time of treatment planning, the mean dose to a single parotid gland should be kept below 26Gy, the mean dose to a single submandibular gland below 39Gy, the mean dose to the mandible below 60 to 65Gy and the D2% to a single temporomandibular joint below 65Gy. These dose constraints could be further improved with data extracted from...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Pointreau Y, Lizée T, Bensadoun RJ, Boisselier P, Racadot S, Thariat J, Graff P Tags: Cancer Radiother Source Type: research

[The dawn of radiotherapy, between strokes of genius, dramas and controversies].
Abstract Radiotherapy is 120 years old. A few months only after the discoveries of Roentgen, Becquerel and Marie and Pierre Curie, a few scientists tried to use the newly discovered rays to treat patients. The question of the name of the first "radiation therapist" remains debated. Although often proposed, Emil Grubbé from Chicago seems to have been disqualified. Leopold Freund from Vienna treated a benign cutaneous lesion. Finally, Victor Despeignes from Lyon appears to be the most serious candidate, having treated in 1896 a gastric cancer, and obtaining a very significant tumour regres...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Cosset JM Tags: Cancer Radiother Source Type: research

[Partial breast irradiation technique with external beam radiation therapy and brachytherapy].
vi JM Abstract Accelerated Partial Breast Irradiation (APBI) appears to be an efficient therapeutic modality provided that it uses strict selection criteria and a reliable and well-managed technique. The techniques that enable to deliver postoperative APBI are interstitial brachytherapy, endocavitary brachytherapy and external beam radiation therapy. Once an appropriate selection of the candidates is made, each radiation technique needs an exact target volume definition and a strict compliance with its own dosimetric constraints. Results of ongoing randomized trials should increase our knowledge of all these param...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Chand-Fouché ME, Lam Cham Kee D, Gautier M, Hannoun-Levi JM Tags: Cancer Radiother Source Type: research

[Radiotherapy in localized stages of follicular and diffuse non-Hodgkin's lymphomas].
e; MA Abstract Treatment with monoclonal antibodies, especially rituximab, is more and more frequent and questions the interest of radiotherapy in limited stages of diffuse B-cell large cell and follicular non-Hodgkin's lymphomas. From a review of literature, it appears that radiotherapy is of interest in bulky disease, patients with incomplete metabolic response, elderly patients receiving short chemotherapy and those with recurrence after exclusive chemotherapy. Finally, this article gives recommendations on available techniques of radiotherapy and doses to be delivered. PMID: 27614527 [PubMed - as supplied...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Demoor-Goldschmidt C, Agape P, Barillot I, Mahé MA Tags: Cancer Radiother Source Type: research

[Robust treatment planning in proton therapy].
The objective of this paper is to present a vision for the management of uncertainties in proton therapy in the continuity of formalisms established for X-rays. The latter are first summarized before discussing the necessary developments in order to consistently apply them to protons. PMID: 27614528 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Sterpin E, Barragan A, Souris K, Lee JA Tags: Cancer Radiother Source Type: research

[Intensity-modulated radiotherapy of head and neck cancers. Dose constraint for spinal cord and brachial plexus].
Abstract Given the ballistic opportunities it offers, intensity-modulated radiotherapy has emerged as the gold standard treatment for head and neck cancers. Protection of organs at risk is one of the objectives of optimization during the planning process. The compliance of dose constraints to the nervous system must be prioritized over all others. To avoid complications, it is recommended to respect a maximum dose of 50Gy to the spinal cord, and 60Gy to the brachial plexus using conventional fractionation of 2Gy per fraction. These constraints can be adapted depending on the clinical situation; they will probably ...
Source: Cancer Radiotherapie - September 6, 2016 Category: Cancer & Oncology Authors: Boisselier P, Racadot S, Thariat J, Graff P, Pointreau Y Tags: Cancer Radiother Source Type: research

[Surgery for soft-tissue sarcomas of the limbs and trunk wall].
lot S Abstract Soft-tissue sarcoma of the limbs or the trunk wall determine a heterogeneous group of tumours that tends to receive a more individualized approach. The surgeon in charge with soft-tissue sarcoma has to be familiar with these tumours in order to deliver an adequate treatment. Most important is the initial diagnostic procedure, comprising imaging with MRI, a core needle biopsy, and in France, referral to a centre of expertise within the clinical network NETSARC. Prior to surgery, a multidisciplinary conference determines its moment and the extent of surgical resection within the frame of a multidiscip...
Source: Cancer Radiotherapie - September 1, 2016 Category: Cancer & Oncology Authors: Stoeckle E, Michot A, Henriques B, Sargos P, Honoré C, Ferron G, Meeus P, Babre F, Bonvalot S Tags: Cancer Radiother Source Type: research

[Needs and financing of radiotherapy in France and Europe].
Abstract Access to high-quality and safe radiotherapy is a prerequisite to assure optimal oncology care in a multidisciplinary environment. In view of supporting long-term radiotherapy planning, actual and predicted radiotherapy needs should be put in context of the nowadays' available resources. The present article reviews the existing data on radiotherapy resources and needs, along with the prevailing reimbursement systems in the different European countries, with a specific emphasis on France. It describes potential incentives of different financing systems on clinical practice and highlights how knowledge of t...
Source: Cancer Radiotherapie - September 1, 2016 Category: Cancer & Oncology Authors: Defourny N, Lievens Y Tags: Cancer Radiother Source Type: research

[Definition of accurate planning target volume margins for esophageal cancer radiotherapy].
Abstract More than 4000 cases of esophagus neoplasms are diagnosed every year in France. Radiotherapy, which can be delivered in preoperative or exclusive with a concomitant chemotherapy, plays a central role in treatment of esophagus cancer. Even if efficacy of radiotherapy no longer has to be proved, the prognosis of esophagus cancer remains unfortunately poor with a high recurrence rate. Toxicity of esophageal radiotherapy is correlated with the irradiation volume, and limits dose escalation and local control. Esophagus is a deep thoracic organ, which undergoes cardiac and respiratory motion, making the ra...
Source: Cancer Radiotherapie - September 1, 2016 Category: Cancer & Oncology Authors: Lesueur P, Servagi-Vernat S Tags: Cancer Radiother Source Type: research

[Head and neck intensity-modulated radiation therapy: Normal tissues dose constraints. Pharyngeal constrictor muscles and larynx].
Abstract Radio-induced pharyngolaryngeal chronic disorders may challenge the quality of life of head and neck cancer long survivors. Many anatomic structures have been identified as potentially impaired by irradiation and responsible for laryngeal edema, dysphonia and dysphagia. Some dose constraints might be plausible such as keeping the mean dose to the pharyngeal constrictor muscles under 50 to 55Gy, the mean dose to the supra-glottic larynx under 40 to 45Gy and, if feasible, the mean dose to the glottic larynx under 20Gy. A reduction of the dose delivered to the muscles of the floor of the mouth and the cervic...
Source: Cancer Radiotherapie - September 1, 2016 Category: Cancer & Oncology Authors: Graff P, Woisard V, Racadot S, Thariat J, Pointreau Y Tags: Cancer Radiother Source Type: research

[Sarcoma developed in irradiated area: Preliminary results of the SARI trial].
Abstract Radiotherapy and surgery are the two main pillars of the locoregional treatment of cancer. The risk of second malignancy is better evaluated and constitutes a major issue regarding radioprotection of the patients. Among malignant disease observed in the surviving irradiated patients, the occurrence of sarcoma is a rare event but associated with a poor outcome since the 5 year overall survival is estimated at 10 to 35 %. The SARI protocol, written in 2011, included 120 patients and 240 controlled patients, irradiated in the same conditions but without sarcoma observed during the fo...
Source: Cancer Radiotherapie - September 1, 2016 Category: Cancer & Oncology Authors: Maingon P, Mirjolet C, Diallo I, Veres C, Collin F, Italiano A, Chibon F, Merlin JL, Coindre JM Tags: Cancer Radiother Source Type: research

[Adaptative radiotherapy: The case for MRI-guided radiotherapy].
Abstract The concept of image-guided radiotherapy benefits from the development of magnetic resonance imaging (MRI) associated with different capacities of tissue analyses such as spectroscopy or diffusion analysis. The production of devices allowing the repositioning of patients through MRI represents a strong added value without delivering any additional dose to the patient while the optimization of the adaptative strategies are facilitated by a better contrast of the soft tissues compared to the scanner. The advantages of MRI are well demonstrated for brain tumours, head and neck carcinomas, pelvic tumors, medi...
Source: Cancer Radiotherapie - September 1, 2016 Category: Cancer & Oncology Authors: Maingon P Tags: Cancer Radiother Source Type: research

[Respiratory synchronization and breast radiotherapy].
This article summarizes the respiratory motion and its effects on imaging, dose calculation and dose delivery by radiotherapy for breast cancer. We will review the methods of respiratory synchronization available for breast radiotherapy to minimize the respiratory impact and to spare organs such as heart and lung. PMID: 27592267 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 30, 2016 Category: Cancer & Oncology Authors: Mège A, Ziouèche-Mottet A, Bodez V, Garcia R, Arnaud A, de Rauglaudre G, Pourel N, Chauvet B Tags: Cancer Radiother Source Type: research

[Normofractionated breast irradiation in breast cancer. Indications and benefits].
Abstract Whole-breast normofractionated irradiation following breast-conserving surgery is the reference treatment. It delivers a dose of 50Gy in 25 fractions of 2Gy to the reference point, and, in some patients, an additional dose of 16Gy in 8 fractions of 2Gy in the tumor bed. Long-term results and toxicity of this irradiation scheme was prospectively evaluated in several randomised trials and meta-analyses, in invasive cancers as well as in ductal carcinoma in situ. The average 10-year rate of in breast recurrences was 6 % in these trials, with limited cardiac and pulmonary toxicity and limited r...
Source: Cancer Radiotherapie - August 30, 2016 Category: Cancer & Oncology Authors: Fourquet A, Krhili SL, Campana F, Chilles A, Kirova YM Tags: Cancer Radiother Source Type: research

[Role of radiotherapy in the management of node-positive prostate cancer].
eau A Abstract Node-positive prostate cancer patients represent a small proportion of all prostate cancers for whom limited prospective information is available. Most retrospective or cohort data strongly suggest however that radiotherapy combined with androgen-depriving therapies is the preferable treatment in this setting. Only randomized clinical trials would be able to better define both radiotherapy (dose? volume? fractionation?) and androgen-depriving therapies (duration? role of novel androgen-depriving therapy?) modalities. PMID: 27575537 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 25, 2016 Category: Cancer & Oncology Authors: Supiot S, Doré M, Rio E, Cellier P, Mesguez-Nebout N, Goineau A Tags: Cancer Radiother Source Type: research

[Proton therapy].
i D Abstract Proton therapy is an optimized radiotherapy technique. Today, the technical improvement provides reliable machines. The therapeutic indications are clearer even though therapeutic trials should confirm the current guidelines. A better knowledge in radiobiology could be useful if it is integrated in the treatment planning system. A new organization of care will definitively stabilize the number of patients for which treatment will be relevant. This organization will prepare the future expansion of this technique. PMID: 27568293 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 23, 2016 Category: Cancer & Oncology Authors: Noël G, Antoni D Tags: Cancer Radiother Source Type: research

[Radiotherapy for retroperitoneal sarcomas].
The objective of this article is to present data on preoperative irradiation in terms of dose, volumes and optimal radiotherapy techniques for the treatment of this rare disease. PMID: 27568294 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 23, 2016 Category: Cancer & Oncology Authors: Sargos P, Stoeckle E, Henriques de Figueiredo B, Antoine M, Delannes M, Mervoyer A, Kantor G Tags: Cancer Radiother Source Type: research

[Nasal cavity and paranasal sinus cancer].
Abstract The nasal cavity and parasinusal cancer are rare (10% of tumors of the head and neck) and are mainly represented by squamous cell carcinoma of the nasal cavity or the maxillary sinus and adenocarcinoma of the ethmoid sinus (occupational disease, wood dust). The most common clinical sign is nasal obstruction, but tumors can also manifest as rhinorrhea and/or epistaxis (usually unilateral signs). A magnetic resonance imaging of the facial structure is systematic for staging before treatment. The treatment consists of a first surgery if the patient is operable with a resectable tumor. If it is not the case, ...
Source: Cancer Radiotherapie - August 11, 2016 Category: Cancer & Oncology Authors: Peyraga G, Lafond C, Pointreau Y, Giraud P, Maingon P Tags: Cancer Radiother Source Type: research

[Radiotherapy in cancers of the oesophagus, the gastric cardia and the stomach].
This article on the indications for radiotherapy and the techniques used in oesophageal and gastric cancers is included in a special issue dedicated to national recommendations from the French society of radiation oncology (SFRO) on radiotherapy indications, planning, dose prescription, and techniques of radiotherapy delivery. PMID: 27523409 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 10, 2016 Category: Cancer & Oncology Authors: Créhange G, Huguet F, Quero L, N'Guyen TV, Mirabel X, Lacornerie T Tags: Cancer Radiother Source Type: research

[Radiotherapy for brain metastases].
l G Abstract Radiotherapy for brain metastases has become more multifaceted. Indeed, with the improvement of the patient's life expectancy, side effects must be undeniably avoided and the retreatments or multiple treatments are common. The cognitive side effects should be warned and the most modern techniques of radiation therapy are used regularly to reach this goal. The new classifications of patients with brain metastases help guiding treatment more appropriately. Stereotactic radiotherapy has supplanted whole brain radiation therapy both for patients with metastases in place and for those who underwent surgery...
Source: Cancer Radiotherapie - August 10, 2016 Category: Cancer & Oncology Authors: Latorzeff I, Antoni D, Gaudaire-Josset S, Feuvret L, Tallet-Richard A, Truc G, Noël G Tags: Cancer Radiother Source Type: research

[Radiotherapy for anal canal cancers].
ger S Abstract Indications, doses and techniques of conformal radiotherapy for anal canal cancers are presented. The recommendations for delineation of the target volumes and organs at risk are detailed. PMID: 27523411 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 10, 2016 Category: Cancer & Oncology Authors: Peiffert D, Créhange G, Vendrely V, Baumann AS, Faivre JC, Huger S Tags: Cancer Radiother Source Type: research

[Prostate cancer brachytherapy].
, de Crevoisier R Abstract Prostate brachytherapy techniques are described, concerning both Iodine 125 high dose rate brachytherapy. The following parts are presented: brachytherapy indications, technical description, immediate postoperative management and post-treatment evaluation, and 4 to 6 weeks as well as long-term follow-up. PMID: 27523412 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 10, 2016 Category: Cancer & Oncology Authors: Pommier P, Guérif S, Peiffert D, Créhange G, Hannoun-Lévi JM, de Crevoisier R Tags: Cancer Radiother Source Type: research

[Radiotherapy for intrathoracic metastases].
Abstract Indication, doses, and technique of radiotherapy, for intrathoracic metastases are presented. The recommendations for delineation of the target volumes and organs at risk are detailed. PMID: 27523413 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 10, 2016 Category: Cancer & Oncology Authors: Giraud P, Lacornerie T, Mornex F Tags: Cancer Radiother Source Type: research

[Radiotherapy of rectal carcinoma].
re AA Abstract Indications, doses and techniques of conformal radiotherapy for rectal carcinoma are presented. The recommendations for delineation of the target volumes and organs at risk are detailed. PMID: 27523414 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 10, 2016 Category: Cancer & Oncology Authors: Peiffert D, Créhange G, Vendrely V, Baumann AS, Faivre JC, Huger S, Serre AA Tags: Cancer Radiother Source Type: research

[Radiotherapy of adult soft tissue sarcoma].
The objective of this paper is to report the state of the art regarding indications and treatment techniques of main soft tissue sarcoma localisations. PMID: 27523415 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 10, 2016 Category: Cancer & Oncology Authors: Le Péchoux C, Moureau-Zabotto L, Llacer C, Ducassou A, Sargos P, Sunyach MP, Thariat J Tags: Cancer Radiother Source Type: research

[Prevention of radio-induced cancers].
Abstract The article deals with the prevention of cancers only directly related to therapeutic radiation which are distinguished from "secondary cancer". The consideration of the risk of radiation-induced cancers after radiation therapy, although it is fortunately rare events, has become indispensable today. With a review of the literature, are detailed the various involved parameters. The age of the irradiated patient is one of the main parameters. The impact of the dose is also discussed based on the model used, and based on clinical data. Other parameters defining a radiation treatment are discussed o...
Source: Cancer Radiotherapie - August 10, 2016 Category: Cancer & Oncology Authors: Cosset JM, Chargari C, Demoor C, Giraud P, Helfre S, Mornex F, Mazal A Tags: Cancer Radiother Source Type: research

[Radiotherapy of benign intracranial tumors].
Abstract Most of the benign intracranial tumors are meningiomas, vestibular schwannomas, pituitary adenomas, craniopharyngiomas, and glomus tumors. Some of them grow very slowly, and can be observed without specific treatment, especially if they are asymptomatic. Symptomatic or growing tumors are treated by surgery, which is the reference treatment. When surgery is not possible, due to the location of the lesion, or general conditions, radiotherapy can be applied, as it is if there is a postoperative growing residual tumor, or a local relapse. Indications have to be discussed in polydisciplinary meetings, with pre...
Source: Cancer Radiotherapie - August 10, 2016 Category: Cancer & Oncology Authors: Delannes M, Latorzeff I, Chand ME, Huchet A, Dupin C, Colin P Tags: Cancer Radiother Source Type: research

[Radiation therapy of pancreatic cancer].
Abstract Currently, the use of radiation therapy for patients with pancreatic cancer is subject to discussion. In adjuvant setting, the standard treatment is 6 months of chemotherapy with gemcitabine and capecitabine. Chemoradiation (CRT) may improve the survival of patients with incompletely resected tumors (R1). This should be confirmed by a prospective trial. Neoadjuvant CRT is a promising treatment especially for patients with borderline resectable tumors. For patients with locally advanced tumors, there is no a standard. An induction chemotherapy followed by CRT for non-progressive patients reduces the r...
Source: Cancer Radiotherapie - August 10, 2016 Category: Cancer & Oncology Authors: Huguet F, Mornex F, Orthuon A Tags: Cancer Radiother Source Type: research