[Image-guided radiotherapy: Overview of devices and practice in France in 2015].
ier R Abstract Image-guided radiation therapy consists in acquiring in-room images to improve patient and mainly tumour set up accuracy. Many devices based on ionising or non-ionising radiations were designed in recent years. The use of such devices is of major importance in the management of patient radiotherapy courses. Those imaging sessions require to clearly define procedures in each radiotherapy department (image modality, acquisition frequency, corrective action, staff training and tasks). A quick review of the different existing image-guided radiation therapy devices is presented. In addition, the results ...
Source: Cancer Radiotherapie - September 2, 2015 Category: Cancer & Oncology Authors: Delpon G, Chiavassa S, Supiot S, Boutry C, Darréon J, Desrousseaux J, Lafay F, Leysalle A, de Crevoisier R Tags: Cancer Radiother Source Type: research

[Ultrasmall nanoparticles for radiotherapy: AGuIX].
Abstract Since twenty years, many nanoparticles based on high atomic number elements have been developed as radiosensitizers. The design of these nanoparticles is limited by the classical rules associated with the development of nanoparticles for oncology and by the specific ones associated to radiosensitizers, which aim to increase the effect of the dose in the tumor area and to spare the health tissues. For this application, systemic administration of nanodrugs is possible. This paper will discuss the development of AGuIX nanoparticles and will emphasize on this example the critical points for the development of...
Source: Cancer Radiotherapie - September 2, 2015 Category: Cancer & Oncology Authors: Lux F, Detappe A, Dufort S, Sancey L, Louis C, Carme S, Tillement O Tags: Cancer Radiother Source Type: research

[Follow-up after stereotactic body radiation therapy for liver tumours: A review of the literature and recommendations].
Abstract Stereotactic body radiation therapy is a modern approach for delivering ablative high doses of irradiation in small volumes. This technique is being developed for the treatment of liver tumors, such as hepatocellular carcinoma, cholangiocarcinoma, or liver metastases. It represents a real alternative to surgical resection or liver transplantation when patients are inoperable or when tumours are unresectable. It is mandatory to standardize and simplify the current methods of evaluation and monitoring in order to benefit from a better understanding of the effectiveness and of the tolerance of this new treat...
Source: Cancer Radiotherapie - September 2, 2015 Category: Cancer & Oncology Authors: Janoray G, Mornex F Tags: Cancer Radiother Source Type: research

[Recommendations for the management of cancers of the anal canal].
Abstract Anal canal carcinomas remain rare, but their management has improved recently. The PET-CT is now used as a standard at the first diagnosis and after relapses. The introduction of intensity-modulated irradiation techniques makes it possible to better conform the pelviperineal and inguinal volumes, improving the homogeneity of the irradiation while sparing some pelvic structures, thus reducing acute and late effects. Nevertheless, the conversion from 3D to intensity-modulated radiotherapy needs a specific and careful approach, mainly for the management of the perineal region, where relapses and complication...
Source: Cancer Radiotherapie - September 1, 2015 Category: Cancer & Oncology Authors: Peiffert D Tags: Cancer Radiother Source Type: research

[Follow-up after lung stereotactic radiotherapy].
d P Abstract Nowadays, bronchopulmonary stereotactic body radiotherapy is recommended as the standard of care in treating medically inoperable patients with curative intent according to guidelines of multiple organizations. Changes in lung density on computed tomography are common after stereotactic body radiotherapy and can confound the early detection of recurrence. Radiation-induced computed tomography lung changes after bronchopulmonary stereotactic body radiotherapy differ from those observed after conventionally fractionated radiotherapy. It is mandatory to standardize and simplify our clinical, radiological...
Source: Cancer Radiotherapie - August 31, 2015 Category: Cancer & Oncology Authors: Waissi W, Noël G, Giraud P Tags: Cancer Radiother Source Type: research

[Current use and prospects for hadron therapy in 2015].
Abstract Hadron therapy (including protons and ions) is still expanding worldwide, although still limited by the cost and thus the number of available facilities. If the historical indications remain eye melanomas, skull base tumours and paediatric tumours for protontherapy; and salivary glands, paranasal sinus and nasal cavity tumours, and soft tissue sarcomas for carbon ions, no conclusion can be drawn about the role of these modalities for other tumours, such as prostate, lung cancers. Since 2013, more than 100 clinical trials are on-going, including comparisons between advanced photons modalities, protont...
Source: Cancer Radiotherapie - August 31, 2015 Category: Cancer & Oncology Authors: Feuvret L, Calugaru V, Ferrand R Tags: Cancer Radiother Source Type: research

[Current management of hepatocellular carcinoma].
ray C Abstract Hepatocellular carcinoma is the major complication of chronic liver diseases and particularly of cirrhosis whatever its etiology. Once encountered mainly in the endemic countries of hepatitis B and C, the incidence of hepatocellular carcinoma (6/100,000) is parallel to the global development of diabetes, overweight and alcohol consumption. Little progress has been made for this cancer, whose mortality is 100 % at 10 years. Liver transplantation is the only truly curative treatment (survival more than 50 % at 10 years) since it allows the eradication of hepatocellular carcinoma an...
Source: Cancer Radiotherapie - August 31, 2015 Category: Cancer & Oncology Authors: Ruiz I, Féray C Tags: Cancer Radiother Source Type: research

[Adaptive radiotherapy in routine: The radiation oncologist's point of view].
Abstract Adaptive radiotherapy is defined as all processes leading to the modification of a treatment plan on the basis of patient-specific variations observed during the course of a treatment. This concept is currently of particular relevance due to the development of onboard volumetric imaging systems, which allow for daily viewing of variations in both tumour and organs at risk in terms of position, shape or volume. However, its application in routine clinical practice is limited due to the demanding nature of the processes involved (re-delineation and replanning) and increased dependence on available human res...
Source: Cancer Radiotherapie - August 31, 2015 Category: Cancer & Oncology Authors: Henriques de Figueiredo B, Petit A, Sargos P, Kantor G, Pouypoudat C, Saut O, Zacharatou C, Antoine M Tags: Cancer Radiother Source Type: research

[Adaptive radiation therapy for non-small cell lung cancer].
aud P Abstract Anatomical changes and tumor regression during thoracic radiotherapy may alter the treatment volumes. These modifications are not taken into account into set-up or motion margins used for treatment planning. Their dosimetric impact could be significant and a better understanding of the changes occurring during the 6 to 7weeks of treatment could be useful in order to define quantitative thresholds before a new treatment planning is needed. Margins could also be reduced in order to better spare organs at risk and perform targeted dose escalation. This review assesses the potential of morphologic and m...
Source: Cancer Radiotherapie - August 31, 2015 Category: Cancer & Oncology Authors: Bibault JE, Arsène-Henry A, Durdux C, Mornex F, Hamza S, Trouette R, Thureau S, Faivre JC, Boisselier P, Lerouge D, Paragios N, Giraud P Tags: Cancer Radiother Source Type: research

[Follow-up after radiotherapy of anal canal carcinoma].
This article offers a review of the various post-treatment surveillance options both for early diagnosis of relapse and care for late treatment effects. While follow-up remains mostly clinical, we will discuss morphologic (endorectal echoendoscopy, pelvic magnetic resonance imaging, tomodensitometry and positron emission tomography) and biologic (squamous cell carcinoma antigen and pathology) follow-up so as to determine their diagnostic and prognostic value. PMID: 26323891 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 28, 2015 Category: Cancer & Oncology Authors: Meillan N, Huguet F, Peiffert D Tags: Cancer Radiother Source Type: research

Clinical radiotherapy audits in Belgium, 2011-2014.
Abstract Systematic clinical radiotherapy audits have been introduced in Belgium in 2011, as part of the Federal Cancer Plan. This is in compliance with article 11 of the 97/43 Council directive of Euratom states, translated into the Belgian legislation by royal decree in 2002. The principle of clinical audits has thus been part of the federal legal requirements for more than 10 years. However, its application had to wait for the development of a practical approach: what authority will audit, who will be the auditors, along which methodology, at what frequency, etc. Since 2002, the Federal College of Radiotherapy ...
Source: Cancer Radiotherapie - August 27, 2015 Category: Cancer & Oncology Authors: Scalliet PG, Federal College of Radiotherapy, Brussels Tags: Cancer Radiother Source Type: research

[Nutritional management of patients with head and neck cancer treated with radiation].
tot F Abstract Radiotherapy and chemotherapy are standard treatment of head and neck cancer alone or associated to surgical treatment. Early (during treatment or the following weeks) and late side effects contribute to malnutrition in this population at risk. In this context, nutritional support adapted by dietary monitoring and enteral nutrition (nasogastric tube or gastrostomy) are often necessary. The early identification of the patients with high malnutrition risk and requiring enteral nutrition is necessary to improve the tolerance and efficacy of treatment. PMID: 26321684 [PubMed - as supplied by publis...
Source: Cancer Radiotherapie - August 27, 2015 Category: Cancer & Oncology Authors: Thureau S, Lefebvre L, Dandoy S, Guérault F, Ebran M, Lebreton M, Veresezan O, Rigal O, Clatot F Tags: Cancer Radiother Source Type: research

[Recommendations for inspections of the French nuclear safety authority].
Abstract The French nuclear safety authority is responsible for the control of radiation protection in radiotherapy since 2002. Controls are based on the public health and the labour codes and on the procedures defined by the controlled health care facility for its quality and safety management system according to ASN decision No. 2008-DC-0103. Inspectors verify the adequacy of the quality and safety management procedures and their implementation, and select process steps on the basis of feedback from events notified to ASN. Topics of the inspection are communicated to the facility at the launch of a campaign...
Source: Cancer Radiotherapie - August 27, 2015 Category: Cancer & Oncology Authors: Rousse C, Chauvet B Tags: Cancer Radiother Source Type: research

[Radiotherapy of bone metastases: Which fractionations?]
Abstract First-line palliative radiotherapy for painful bone metastases is an effective treatment whatever its fractionation (single or multiple fractions). It is also indicated after failure or insufficient effect of a first irradiation, or the appearance of new painful site. Other indications are spinal cord compression, either as an adjuvant to surgery or as sole treatment, and after surgery for long bone metastases. The development of high precision techniques (stereotactic conditions) widens the possibility of re-irradiation when tolerance doses to normal tissues have already been delivered. Local control and...
Source: Cancer Radiotherapie - August 27, 2015 Category: Cancer & Oncology Authors: Thureau S, Leysalle A, Faivre JC, Lagrange JL Tags: Cancer Radiother Source Type: research

[Which rules apply to hypofractionated radiotherapy?]
pon G Abstract Hypofractionated radiotherapy is now more widely prescribed due to improved targeting techniques (intensity modulated radiotherapy, image-guided radiotherapy and stereotactic radiotherapy). Low dose hypofractionated radiotherapy is routinely administered mostly for palliative purposes. High or very high dose hypofractionated irradiation must be delivered according to very strict procedures since every minor deviation can lead to major changes in dose delivery to the tumor volume and organs at risk. Thus, each stage of the processing must be carefully monitored starting from the limitations and the c...
Source: Cancer Radiotherapie - August 25, 2015 Category: Cancer & Oncology Authors: Supiot S, Clément-Colmou K, Paris F, Corre I, Chiavassa S, Delpon G Tags: Cancer Radiother Source Type: research

[How to identify frailty in older patients with cancer? Available tools].
Abstract Management of cancer in the elderly needs more attention than in younger patients mainly because of comorbidities and geriatric syndromes. Each frailty encountered will facilitate adverse events and complications which are more frequent and more severe in the elderly and have to be anticipated to control for the risk of organ failure and dependencies. Fortunately, tools which have been developed and validated by geriatricians, are available to the oncologists and their validity has been demonstrated in oncology. Yet, they are quite time-consuming and consequently available for a minority of patients. Furt...
Source: Cancer Radiotherapie - August 25, 2015 Category: Cancer & Oncology Authors: Bellera C, Soubeyran P Tags: Cancer Radiother Source Type: research

[Radiation therapy and immunomodulation: Focus on experimental data].
The objective of this article is to review how tumour cells interact with the immune system and how ionizing radiation modulate this interaction and finally the combination of perspectives of immunotherapy and ionizing radiation by focusing on existing clinical data. PMID: 26293415 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 17, 2015 Category: Cancer & Oncology Authors: Deutsch É, Lévy A, Chargari C Tags: Cancer Radiother Source Type: research

[Radiotherapy in elderly patients, recommendations for the main localizations: Breast, prostate and gynaecological cancers].
Abstract Modifications of radiotherapy indications or schedules because of age could be discussed in view of a different evolution of the disease or because of specific toxicities. One important aim is to decrease the number of hospital transports. For breast cancer, the rate of local relapse after lumpectomy is lower in old patients; moreover, characteristics of the disease are often more favourable (hormonosensitivity, low grade). However, adjuvant irradiation decreases significantly the incidence of breast relapse and must be systematically proposed. Hypofractionnated schedules must be recommended; limited data...
Source: Cancer Radiotherapie - August 14, 2015 Category: Cancer & Oncology Authors: Hennequin C, Guillerm S, Quero L Tags: Cancer Radiother Source Type: research

[Which constraints for which organs at risk in radiotherapy for adult patients?]
l G Abstract The delineation of organs at risk is a part of the planning of irradiation treatments. With the delineation of the target volumes, this task is essential and is followed by the appropriate calculations of a dose distribution from radiation beams and the validation of the treatment plan. The contouring of organs at risk could influence the dosimetric parameters, treatment planning and also the outcome of the patient. The treatment intent (curative or palliative), doses and fractionations and also the type of organs at risk have an impact on the delineation. Optimized radiation techniques and reirradiat...
Source: Cancer Radiotherapie - August 14, 2015 Category: Cancer & Oncology Authors: Antoni D, Noël G Tags: Cancer Radiother Source Type: research

[Follow-up after radiation therapy for cervical cancer].
Abstract Radiation therapy plays a central role in treatment strategies of cervical cancer. Follow-up after external pelvic radiation therapy and brachytherapy is based upon French and international specific recommendations. It aims to assess early tumour response, and to detect local or metastatic recurrences which can be suitable for salvage treatment. Follow-up after radiation therapy for cervical cancer should also assess gastro-intestinal, urinary and sexual toxicities which may have an impact on quality of life. This is a major concern in the evaluation of the results of intensity-modulated radiation therapy...
Source: Cancer Radiotherapie - August 14, 2015 Category: Cancer & Oncology Authors: Cao KI, Mazeron R, Barillot I Tags: Cancer Radiother Source Type: research

[Clinical and paraclinical follow-up after radiotherapy for head and neck cancer].
The objective of this article is to review the modalities of short-term and long-term follow-up of patients who receive a radiotherapy for head and neck cancer. PMID: 26278985 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 13, 2015 Category: Cancer & Oncology Authors: Clément-Colmou K, Troussier I, Bardet É, Lapeyre M Tags: Cancer Radiother Source Type: research

[Radiotherapy for gliomas in adults: What are the stakes of the follow-up?]
on JJ Abstract Linked to the difference of prognosis, the terms and conditions of the follow-up of low-grade and high-grade gliomas treated by irradiation differ highly. Patients treated for a low-grade glioma have prolonged survival. In this case, monitoring of toxicities linked to the treatment is a major objective. Opportunistic infections and depression are corticosteroids side effects widely underestimated. Radionecrosis search and differentiation with recurrent disease are done by MRI. Perfusion and spectroscopy showing a choline/creatine ratio increase are in favour of disease recurrence. Cognitive status a...
Source: Cancer Radiotherapie - August 13, 2015 Category: Cancer & Oncology Authors: Atallah V, Gariel F, Gillon P, Crombé A, Mazeron JJ Tags: Cancer Radiother Source Type: research

[Current status of hypofractionated external beam radiotherapy for early-stage breast cancer].
Abstract The benefits of adjuvant radiotherapy following lumpectomy for early-stage breast cancer are well established. The most widely used method consists of roughly twenty-five fractions of whole-breast irradiation. In recent years, there has been a growing trend towards hypofractionated external beam radiotherapy regimens. Many of these techniques have been shown to be equivalent in terms of tumor control and cosmetic results while minimizing inconvenience and costs both to the patient and health care system. Here, we present the various hypofractionation modalities, patient selection criteria, consensus guide...
Source: Cancer Radiotherapie - August 13, 2015 Category: Cancer & Oncology Authors: Tiberi D, Hijal T, Yassa M Tags: Cancer Radiother Source Type: research

Hypofractionated radiation therapy for prostate cancer: The McGill University Health Center experience.
DISCUSSION: Our technique changed from 3D to intensity modulated radiotherapy with the dose adjusted to 60Gy in 20 fractions. Lastly, we have expanded the program to high-risk patients where IMRT treatments are given to the pelvic nodes (44Gy in 20 fractions) with a simultaneous integrated boost delivery to the prostate (60Gy in the same 20 fractions). Our long-term results have shown that moderate hypofractionated radiotherapy for prostate cancer is safe and provides good tumor control comparable to high-dose conventionally fractionated radiotherapy. This hypofractionated regimen has been routinely used in our institution...
Source: Cancer Radiotherapie - August 13, 2015 Category: Cancer & Oncology Authors: Barbosa Neto O, Souhami L, Faria S Tags: Cancer Radiother Source Type: research

[Surveillance after prostate cancer radiotherapy: Evaluation and management of toxicity and relapse].
This article reports incidence of main side-effects (digestive, urinary and sexual) with their treatments and guidelines for clinical and biological follow-up with strategies of imaging studies and salvage treatments. PMID: 26278989 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 13, 2015 Category: Cancer & Oncology Authors: Dupic G, Hennequin C Tags: Cancer Radiother Source Type: research

[Organ preserving strategies for rectal cancer treatment].
Rullier É Abstract For rectal cancers, the current standard of care consists of chemoradiation followed by radical surgery with total mesorectal excision. Oncologic results are good, especially regarding local recurrence rates, but at the cost of high morbidity rates and poor anorectal, urinary and sexual function results. Since chemoradiation yields 15 to 25% pathological complete response, the role of radical surgery is questioned for patients presenting with good response after chemoradiation and two organ preservation strategies have been offered: watch and wait strategy and local excision strategy. Th...
Source: Cancer Radiotherapie - August 13, 2015 Category: Cancer & Oncology Authors: Vendrely V, Denost Q, Amestoy F, Célérier B, Smith D, Rullier A, Rullier É Tags: Cancer Radiother Source Type: research

[Implementing new technology in radiation oncology: The French agency for nuclear safety (ASN) report].
Phare O, Aubert B Abstract In August 2013, the French nuclear safety agency (ASN) requested the permanent group of experts in radiation protection in medicine (GPMED) to propose recommendations on the implementation of new technology and techniques in radiation oncology. These recommendations were finalized in February 2015 by the GPMED. In April 2015, the ASN sent a letter to the French ministry of health (DGS/DGOS), and its national health agencies (ANSM, INCa, HAS). In these letters, ASN proposed that, from the 12 recommendations made by the GPMED, an action plan should be established, whose...
Source: Cancer Radiotherapie - August 13, 2015 Category: Cancer & Oncology Authors: Lartigau ÉF, Lisbona A, Isambert A, Cadot P, Derreumaux S, Dupuis O, Gérard JP, Ledu D, Mahé MA, Marchesi V, Mazurier J, De Oliveira A, Phare O, Aubert B Tags: Cancer Radiother Source Type: research

[Ultrahigh dose-rate, "flash" irradiation minimizes the side-effects of radiotherapy].
CONCLUSION: Flash irradiation shifted by a large factor the threshold dose required to initiate lung fibrosis without loss of the antitumour efficiency, suggesting that the method might be used to advantage to minimize the complications of radiotherapy. PMID: 26277238 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 12, 2015 Category: Cancer & Oncology Authors: Favaudon V, Fouillade C, Vozenin MC Tags: Cancer Radiother Source Type: research

[How to care for elderly patients with cognitive impairment?]
Abstract Mild cognitive impairment occurs frequently with ageing, concerning memory complaint, attention and executive dysfunction without any consequence on the activities of daily living. They are strongly linked to the presence of vascular risk factors in adulthood. Nevertheless with the continuous progression of life expectancy, the incidence of dementia drastically increases after sixty-five years of age and the number of old people with dementia is expected to increase by 75% in 2030 in France. Caring for elderly patients with cancer needs to face the possibility of cognitive impairment and its consequences ...
Source: Cancer Radiotherapie - August 12, 2015 Category: Cancer & Oncology Authors: Rainfray M Tags: Cancer Radiother Source Type: research

[Are extensive fields useful for radiotherapy of oesophageal cancer?]
CONCLUSION: With 5cm supero-inferior margins added to gross tumour volume, less than 3% of patients had an isolated out-field recurrence. However, half of the patients suffered in-field local recurrence and one third had metastases. These findings advocate for a limited prophylactic nodal irradiation. Trials are ongoing to assess dose escalation or surgery in order to increase local control. PMID: 26232314 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 28, 2015 Category: Cancer & Oncology Authors: Peyraga G, Capitain O, Rousseau D, Rio E, Septans AL, Baton O, Marquis A, Trémolières P, Gustin P, Ménager É, Branger F, Bressolette M, Deutsch É, Paumier A Tags: Cancer Radiother Source Type: research

[Embryonal paratesticular rhabdomyosarcoma: A case report and a literature revue].
We report a case of embryonal paratesticular rhabdomyosarcoma treated in our institution. PMID: 26215365 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 24, 2015 Category: Cancer & Oncology Authors: Ghorbal L, Abid W, Elloumi F, Sallemi T, Frikha M, Daoud J Tags: Cancer Radiother Source Type: research

[Long-term outcome of neoadjuvant radiochemotherapy followed by surgery for oesophageal cancer: A single institute retrospective study about 102 patients].
[Long-term outcome of neoadjuvant radiochemotherapy followed by surgery for oesophageal cancer: A single institute retrospective study about 102 patients]. Cancer Radiother. 2015 Jul 24; Authors: Ruffier-Loubière A, Janoray G, Chapet S, de Calan L, Dumont P, Dorval É, Orain I, Calais G Abstract PURPOSE AND OBJECTIVES: To report survival and morbidity of a large homogeneous cohort of patients with a locally advanced esophageal or cardia carcinoma and put in evidence predictive factors of locoregional control and survival. PATIENTS AND METHODS: Hundred and two patients were treat...
Source: Cancer Radiotherapie - July 24, 2015 Category: Cancer & Oncology Authors: Ruffier-Loubière A, Janoray G, Chapet S, de Calan L, Dumont P, Dorval É, Orain I, Calais G Tags: Cancer Radiother Source Type: research

[Primary neuroendocrine tumours of the breast: A retrospective study of 21 cases and literature review].
CONCLUSION: For primary neuroendocrine carcinoma of the breast, multivariate analysis identified three predictive factors for mortality: disease stage, histological grade and lymph node involvement. PMID: 26215367 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 24, 2015 Category: Cancer & Oncology Authors: Feki J, Fourati N, Mnif H, Khabir A, Toumi N, Khanfir A, Boudawara T, Amouri H, Daoud J, Frikha M Tags: Cancer Radiother Source Type: research

Intensity modulated radiation therapy with simultaneous integrated boost in early breast cancer irradiation. Report of feasibility and preliminary toxicity.
Abstract PURPOSE: To investigate the feasibility and tolerance in the use of adjuvant intensity modulated radiation therapy (IMRT) and simultaneous integrated boost in patients with a diagnosis of breast cancer after breast-conserving surgery. PATIENTS AND METHODS: Between September 2011 to February 2013, 112 women with a diagnosis of early breast cancer (T1-2, N0-1, M0) were treated with IMRT and simultaneous integrated boost after breast-conserving surgery in our institution. A dose of 50Gy in 25 fractions was prescribed to the whole breast and an additional dose of radiation was prescribed on the tumour be...
Source: Cancer Radiotherapie - July 20, 2015 Category: Cancer & Oncology Authors: Fiorentino A, Mazzola R, Ricchetti F, Giaj Levra N, Fersino S, Naccarato S, Sicignano G, Ruggieri R, Di Paola G, Massocco A, Gori S, Alongi F Tags: Cancer Radiother Source Type: research

[Interobserver variability study for daily cone beam computed tomography registration of prostate volumetric modulated arc therapy].
ppe S Abstract PURPOSE: This work evaluated the interobserver variability in cone beam computed tomography (CBCT) registration for prostate cancers treated with intensity-modulated radiotherapy. MATERIAL AND METHODS: Twelve technologists realized 286 CBCT/CT registrations (bone registration followed by prostate to prostate registration). The registration results were compared to those obtained by two radiation oncologists (reference). Each technologist reported the shifts calculated by the software in all three axes. A statistical analysis allowed us to calculate the minimum threshold under which 95% of the o...
Source: Cancer Radiotherapie - July 20, 2015 Category: Cancer & Oncology Authors: Zahra N, Monnet C, Bartha E, Bouilhol G, Boydev C, Courbis M, Le Grévellec M, Bosset M, Zouai M, Fleury B, Clippe S Tags: Cancer Radiother Source Type: research

Impact of screening on clinicopathological features and treatment for invasive breast cancer: Results of two national surveys.
CONCLUSION: A complete national screening coverage clearly provides a favourable modification of breast cancer clinicopathological features. Both locoregional and adjuvant treatments were greatly downscaled. PMID: 26188735 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 15, 2015 Category: Cancer & Oncology Authors: Cutuli B, Dalenc F, Cottu PH, Gligorov J, Guastalla JP, Petit T, Amrate A Tags: Cancer Radiother Source Type: research

[Evolution of the management of paediatric and adult medulloblastoma].
ël G Abstract Medulloblastoma are cerebellar tumours belonging to the group of primitive neuroectodermal tumours (PNET) and are the most common malignant brain tumours of childhood. These tumours are rare and heterogeneous, requiring some multicentric prospective studies and multidisciplinary care. The classical therapeutic approaches are based on clinical, radiological and surgical data. They involve surgery, radiation therapy and chemotherapy. Some histological features were added to characterize risk. More recently, molecular knowledge has allowed to devise risk-adapted strategies and helped to define grou...
Source: Cancer Radiotherapie - June 30, 2015 Category: Cancer & Oncology Authors: Vigneron C, Entz-Werlé N, Lutz P, Spiegel A, Jannier S, Helfre S, Alapetite C, Coca A, Kehrli P, Noël G Tags: Cancer Radiother Source Type: research

[Radioresistance parameters in head and neck cancers and methods to radiosensitize].
Abstract Head and neck cancers have been widely studied concerning their sensitivity to radiation therapy. Several parameters affect tumour response to radiation therapy. Some parameters are linked to the tumour. Large or invasive tumours, localization, such as oral cavity or adenopathy, are factors of radioresistance. Others parameters are linked to the patients themselves. Tobacco intoxication during radiotherapy and a low hemoglobin level contribute to radioresistance. More recently, a positive human papilloma virus (HPV) status has been reported to positively affect radiosensitivity. Finally, other parameters ...
Source: Cancer Radiotherapie - June 25, 2015 Category: Cancer & Oncology Authors: Biau J, Chautard E, Miroir J, Lapeyre M Tags: Cancer Radiother Source Type: research

[Prophylactic axillary radiotherapy for breast cancer].
cute; Abstract Adjuvant radiotherapy, after breast conserving surgery or mastectomy for breast cancer, improves overall survival while decreasing the risk of recurrence. However, prophylactic postoperative radiotherapy of locoregional lymph nodes for breast cancer, particularly of the axillary region, is still controversial since the benefits and the risks due to axillary irradiation have not been well defined. To begin with, when performing conformal radiotherapy, volume definition is crucial for the analysis of the risk-benefit balance of any radiation treatment. Definition and contouring of the axillary lymph n...
Source: Cancer Radiotherapie - June 1, 2015 Category: Cancer & Oncology Authors: Rivera S, Louvel G, Rivin Del Campo E, Boros A, Oueslati H, Deutsch É Tags: Cancer Radiother Source Type: research

[Regional treatment for axillary lymph node micrometastases of breast cancer].
ambaudie É Abstract In patients with breast cancer, axillary lymph node micrometastasis detection has been more frequent with a better definition since the introduction of the sentinel node procedure. In this review, we focus on pN1mi micrometastasis and review the literature in order to determine factors involved in making the decision of a regional treatment. PMID: 26006761 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 22, 2015 Category: Cancer & Oncology Authors: Houvenaeghel G, Cohen M, Jauffret-Fara C, Bannier M, Chéreau-Ewald É, Rua Ribeiro S, Lambaudie É Tags: Cancer Radiother Source Type: research

[Is there a rationale for regional node irradiation in pN1mi and pN0(i+) breast tumours?]
This article looks at the literature in favour of performing axillary irradiation in patients with pN1mi stage breast cancer who have undergone a mastectomy without a complementary axillary lymph node dissection, and in favour of abstention of any further treatment of the axilla in patients with pN0(i+) or pN1mi tumours who have undergone breast conserving surgery and a sentinel lymph node procedure followed by systemic treatment. The impact of regional lymph nodes irradiation in case of axillary involvement 2mm or less is also discussed. PMID: 26006762 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 22, 2015 Category: Cancer & Oncology Authors: Tallet A, Resbeut M Tags: Cancer Radiother Source Type: research

[Irradiation of internal mammary nodes: State of the art].
Abstract In the adjuvant breast cancer treatment, postoperative radiotherapy plays a principal part with an action against the microscopic residual disease in the lymph nodes after mastectomy as well as after breast conserving surgery. This positive effect is observed also in the case of small inner lesions in patients without lymph node involvement. At the same time, there is a recognized risk of cardiac toxicity directly related to the irradiation of internal mammary nodes. This paper is a report on the current available techniques to irradiate the internal mammary nodes, including promising new technology that ...
Source: Cancer Radiotherapie - May 22, 2015 Category: Cancer & Oncology Authors: Kirova YM, de Almeida CE, Fournier-Bidoz N Tags: Cancer Radiother Source Type: research

[Radiosensitivity settings in breast cancer].
Abstract Breast cancers are highly radiosensitive since the risk of recurrences and of mortality after adjuvant radiotherapy following breast-conserving surgery is decreased by 15.7% and 3.8%, respectively at 10years. The total dose if irradiation also significantly increases local control: a boost of 16Gy to the tumour bed after breast-conserving surgery reduces the absolute risk of recurrence by 4% at 10years. Breast cancers are sensitive to the dose per fraction, as shown by the results from four randomized trials which compared standard irradiation (50Gy/25 fractions) with a hypofractionated scheme: no statist...
Source: Cancer Radiotherapie - May 22, 2015 Category: Cancer & Oncology Authors: Lauche O, Azria D, Riou O, Charissoux M, Lemanski C, Bourgier C Tags: Cancer Radiother Source Type: research

Role of hypofractionated radiotherapy in breast locoregional radiation.
Abstract Long-term results of randomised trials have confirmed the safety and efficacy of hypofractionated radiotherapy using approximately 2.6Gy per fraction to lower total doses of 40-42.6Gy delivered over 3weeks, for postoperative treatment of early breast cancer. In these trials, hypofractionated radiotherapy was predominantly used for breast only treatment, while there are fewer trials that specifically examined hypofractionated radiotherapy to the breast plus regional nodes. Hypofractionated locoregional radiation is considered a standard of care in the United Kingdom and in some parts of Canada. We aim to r...
Source: Cancer Radiotherapie - May 21, 2015 Category: Cancer & Oncology Authors: Caudrelier JM, Truong PT Tags: Cancer Radiother Source Type: research

[Which node area should be irradiated after neoadjuvant chemotherapy in breast cancer?]
Abstract In addition to achieve breast conserving surgery after neoadjuvant chemotherapy, its indications are growing, especially in Her2 overexpressing and triple negative breast cancers owing to the emergence of new targeted therapies. Radiotherapy belongs to breast cancer management. However, some questions are still unresolved regarding nodes area irradiation after neoadjuvant chemotherapy. This short communication reviews indications of radiotherapy of node areas in breast cancer after neoadjuvant chemotherapy. PMID: 26004843 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 21, 2015 Category: Cancer & Oncology Authors: Lemanski C, Druet X, Riou O, Ducteil A, Azria D, Bourgier C Tags: Cancer Radiother Source Type: research

[Impact of intensity-modulated radiotherapy on node irradiation for breast cancer].
Abstract Irradiation of node areas is still a complex challenge in external radiotherapy for breast cancer. Acceptable target coverage is always balanced by protection of organs at risk and patient morphology. Intensity-modulated radiotherapy increases the quality of dose distribution on the planning target volume, but modifies dramatically the irradiation coverage of critical structures in a different way compared to 3D treatment. In this paper we analyze this new technique in breast treatment with node regions, its expected gain and potential risks. PMID: 25935257 [PubMed - as supplied by publisher] (Source...
Source: Cancer Radiotherapie - April 29, 2015 Category: Cancer & Oncology Authors: Fenoglietto P, Bourgier C, Riou O, Lemanski C, Azria D Tags: Cancer Radiother Source Type: research

[Does nodal irradiation (clavicular and internal mammary chains) increase the toxicity of adjuvant breast radiotherapy?]
Abstract Treatment volume is a major risk factor of radiation-induced toxicity. As nodal irradiation increases treatment volume, radiation toxicity should be greater. Nevertheless, scientific randomised data do not support this fact. However, a radiation-induced toxicity is possible outside tangential fields in the nodal volumes not related to breast-only treatment. Treatment should not be adapted only to the disease but personalized to the individual risk of toxicity for each patient. PMID: 25937187 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 27, 2015 Category: Cancer & Oncology Authors: Riou O, Bourgier C, Fenoglietto P, Azria D Tags: Cancer Radiother Source Type: research

[Dental state in patients with head and neck cancers].
l G Abstract In France, in 2005, there were approximately 16,000 new cases of head and neck cancer. These cancers have an unfavourable prognosis: the survival rates at 3 and 10 years are 50% and 10% respectively. The consumption of alcohol and tobacco is the most important risk factor; in some countries HPV infection was identified as a risk factor of head and neck tumours. Furthermore, a poor oral hygiene seems to raise this risk. We found many decay and periodontium problems in patients with an upper aerodigestive tract cancer. An evaluation of dental state is necessary before any cancer treatment. Treatments by...
Source: Cancer Radiotherapie - April 27, 2015 Category: Cancer & Oncology Authors: Rouers M, Truntzer P, Dubourg S, Guihard S, Antoni D, Noël G Tags: Cancer Radiother Source Type: research

Dosimetric comparison of moderate deep inspiration breath-hold and free-breathing intensity-modulated radiotherapy for left-sided breast cancer.
This study determined the dosimetric comparison of moderate deep inspiration breath-hold using active breathing control and free-breathing intensity-modulated radiotherapy (IMRT) after breast-conserving surgery for left-sided breast cancer. PATIENTS AND METHODS: Thirty-one patients were enrolled. One free breathe and two moderate deep inspiration breath-hold images were obtained. A field-in-field-IMRT free-breathing plan and two field-in-field-IMRT moderate deep inspiration breath-holding plans were compared in the dosimetry to target volume coverage of the glandular breast tissue and organs at risks for each patient....
Source: Cancer Radiotherapie - April 24, 2015 Category: Cancer & Oncology Authors: Chi F, Wu S, Zhou J, Li F, Sun J, Lin Q, Lin H, Guan X, He Z Tags: Cancer Radiother Source Type: research

[Ductal carcinoma in situ treated with radiation therapy and additional boost].
CONCLUSION: In our experience, women treated for a ductal carcinoma in situ with breast-conserving surgery and whole breast radiation therapy with a boost radiation have a high 10-year local recurrence-free survival rate. PMID: 25921619 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 24, 2015 Category: Cancer & Oncology Authors: Geiss R, Cabel L, Touboul E, Lefranc JP, Daraï É, Lauratet B, Monnier L, Haberer-Guillerm S, Deluen F, Schlienger M, Huguet F Tags: Cancer Radiother Source Type: research