[Hodgkin lymphoma and target definition guidelines].
Abstract Treatment for stage I and II Hodgkin lymphoma is based on a combination of chemotherapy and radiotherapy, with a high successful cure rate. Now, the aim is to decrease toxicity rates. Positron-emission tomography scan is recommended as pretreatment baseline and is very useful to define precisely target volumes for planning radiation therapy. Based on these changes were developed guidelines for modern radiation therapy called involved node and « involved site ». PMID: 30093312 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 6, 2018 Category: Cancer & Oncology Authors: Peignaux K, Gonzague-Casabianca L Tags: Cancer Radiother Source Type: research

[New developments in the management of nasopharyngeal carcinoma].
This article summarizes the recent advances in nasopharyngeal cancer diagnosis, classification, treatment, surveillance and management of recurrences. Chemotherapy timing is discussed, along with arguments in favor of induction chemotherapy in locally advanced cases. As a survival advantage has been suggested for when patients are treated in high volume center it seems reasonable to refer these young patients for treatment to tertiary expert centers, especially given the low incidence of the disease. PMID: 30087054 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 4, 2018 Category: Cancer & Oncology Authors: Blanchard P, Nguyen F, Moya-Plana A, Pignon JP, Even C, Bidault F, Temam S, Ruffier A, Tao Y Tags: Cancer Radiother Source Type: research

[Radiotherapy for HIV-infected patients].
no JP Abstract Since the advent of highly active antiretroviral therapy, cancer incidence is still 2 to 3-fold higher in patients infected by human immunodeficiency virus (HIV) than in the general population, with an increased incidence of malignancies not associated with acquired immunodeficiency syndrome (AIDS). HIV-infected patients cancer treatment does not differ from that in the general population. However, the management of those patients have some particularities due to preexisting comorbid conditions, including metabolic, cardiovascular, renal or hepatic complications and the risk for potential drug - dru...
Source: Cancer Radiotherapie - August 4, 2018 Category: Cancer & Oncology Authors: Quéro L, Gobert A, Spano JP Tags: Cancer Radiother Source Type: research

[Editorial].
PMID: 30082201 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 3, 2018 Category: Cancer & Oncology Authors: Deutsch E, Le groupe TEP-RT Tags: Cancer Radiother Source Type: research

[Radionecrosis following stereotactic radiotherapy of a 3-cm brain metastasis: Can we improve the dosimetric results?]
We report the case of a 30-mm brain metastases treated with stereotactic radiotherapy after initial whole brain radiotherapy, complicated with symptomatic radionecrosis. A dose of 24Gy in three fractions on the 80% isodose were delivered using a dynamic conformal arc technique (Novalis TX®). We realized a dosimetric comparison with: (i) optimization of initial conformal arc plan, (ii) volumetric modulated arctherapy with coplanar arcs and (iii) volumetric modulated arctherapy with coplanar and non-coplanar arcs. The optimal dose planning in terms of planning target volume coverage (99.2%) and normal brain sparing (V24G...
Source: Cancer Radiotherapie - August 2, 2018 Category: Cancer & Oncology Authors: Brun L, Dupic G, Chassin V, Verrelle P, Lapeyre M, Biau J Tags: Cancer Radiother Source Type: research

[Radiation therapy planning for Hodgkin lymphoma: Focus on intensity-modulated radiotherapy, gating, protons. Which techniques to best deliver radiation?]
zar F Abstract The optimization of radiotherapy in these young and long-lived survivors raises the question about the interest of using modern techniques to allow a better distribution of the dose. The choice of the irradiation technique must take into account the incidence of side effects related to radiation. In this context, the definition of the target volumes as well as the verification and monitoring of the delivered processing are essential. International recommendations for treatment fields are based on the "involved node radiotherapy" concept. The best irradiation technique to use remains to be ...
Source: Cancer Radiotherapie - July 31, 2018 Category: Cancer & Oncology Authors: Boros A, Ribrag V, Deutsch É, Chargari C, Izar F Tags: Cancer Radiother Source Type: research

[Technical aspects and indications of extracranial stereotactic radiotherapy].
va YM Abstract Extracranial stereotactic radiotherapy has developed considerably in recent years and is now an important part of the therapeutic alternatives to be offered to patients with cancer. It offers opportunities that have progressively led physicians to reconsider the therapeutic strategy, for example in the case of local recurrence in irradiated territory or oligometastatic disease. The literature on the subject is rich but, yet, there is no real consensus on therapeutic indications. This is largely due to the lack of prospective, randomized studies that have evaluated this technique with sufficient reco...
Source: Cancer Radiotherapie - July 28, 2018 Category: Cancer & Oncology Authors: Bazire L, Darmon I, Calugaru V, Costa É, Dumas JL, Kirova YM Tags: Cancer Radiother Source Type: research

Three-year results after radiotherapy for locally advanced sinonasal adenoid cystic carcinoma, using highly conformational radiotherapy techniques proton therapy and/or Tomotherapy.
CONCLUSION: Combining high-dose proton therapy and Tomotherapy is effective and has moderate toxicity in the treatment of T4 sinonasal adenoid cystic carcinoma involving skull base. PMID: 30064829 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 28, 2018 Category: Cancer & Oncology Authors: Dautruche A, Bolle S, Feuvret L, Le Tourneau C, Jouffroy T, Goudjil F, Zefkili S, Nauraye C, Rodriguez J, Herman P, Calugaru V Tags: Cancer Radiother Source Type: research

Multimodality imaging using PET/CT (18F)-fluorodeoxyglucose for radiotherapy field delineation of localized Hodgkin lymphoma.
We report here the usual procedures of PET/CT acquisition in the radiotherapy environment and propose a more sophisticated description of the different lymph nodes for a more efficient nuclear medicine report to the radiation oncologist. PMID: 30055933 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 25, 2018 Category: Cancer & Oncology Authors: Édeline V, Remouchamps V, Isnardi V, Vander Borght T Tags: Cancer Radiother Source Type: research

[Small cell neuroendocrine carcinoma of the bladder: Report of five cases and a review of the literature].
We report our experience in the management of these tumours with literature review. PMID: 30049597 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 23, 2018 Category: Cancer & Oncology Authors: Safini F, Jouhadi H, Marnissi F, Bouchbika Z, Benchakroun N, Tawfiq N, Sahraoui S, Benider A Tags: Cancer Radiother Source Type: research

Role of FDG PET-CT in the treatment management of Hodgkin lymphoma.
ine V Abstract Fluorodeoxyglucose (FDG) positons emission tomography (PET)-computed tomography (CT) is used in many ways at baseline and during the treatment of patients with Hodgkin lymphoma. Many properties of the technique are used in the different steps of patient's management. Initial staging with PET-CT is more accurate than conventional imaging and PET-CT also became the gold standard imaging at the end of treatment with a negative PET-CT mandatory for reaching a complete remission. Early assessment of response by PET-CT is one of the most powerful prognostic factors for progression-free survival of patient...
Source: Cancer Radiotherapie - July 19, 2018 Category: Cancer & Oncology Authors: Berriolo-Riedinger A, Becker S, Casasnovas O, Vander Borght T, Édeline V Tags: Cancer Radiother Source Type: research

[Bone metastases radiotherapy: Multi-approaches literature review].
A, Noël G Abstract External beam radiation therapy is an efficient treatment, which relieves pain associated with bone metastases, and is prescribed in worldwide. Although bone metastases palliative irradiation recommendations exist, international clinical practices remain variable. The purpose of this article is to show the clinical practices evolution though clinical trials, cost studies and techniques' progression. PMID: 30001971 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 9, 2018 Category: Cancer & Oncology Authors: Le Fèvre C, Antoni D, Thiéry A, Noël G Tags: Cancer Radiother Source Type: research

Salvage brachytherapy as a modern reirradiation technique for local cancer failure: The Phoenix is reborn from its ashes.
ute;hange G Abstract The treatment of local recurrence of a previously irradiated cancer or a second cancer arising in-field remains challenging. Ultimately, the objective of salvage therapy is to control disease while ensuring minimal collateral damage, thereby optimizing both cancer and toxicity outcomes. Reirradiation has historically been associated with unacceptable toxicity and a limited benefit. Brachytherapy offers the best dose distribution and a high radiation dose to the target volume while better protecting surrounding previously irradiated healthy tissues. The management of local cancer recurrence in ...
Source: Cancer Radiotherapie - May 30, 2018 Category: Cancer & Oncology Authors: Quivrin M, Peignaux-Casasnovas K, Martin É, Rouffiac M, Thibouw D, Chevalier C, Vulquin N, Aubignac L, Truc G, Créhange G Tags: Cancer Radiother Source Type: research

Implementation of failure mode and effective analysis for high dose rate brachytherapy at Tata Memorial Hospital, Mumbai, India.
CONCLUSIONS: Failure mode and effective analysis is a useful tool that uses a systematic approach for quality management of a specific process. PMID: 29859762 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 30, 2018 Category: Cancer & Oncology Authors: Swamidas J, Khanna N, Mahantshetty U, Somesan V, Deshpande DD, Shrivastava SK Tags: Cancer Radiother Source Type: research

[Prostate brachytherapy: New techniques, new indications].
Abstract Prostate brachytherapy has been for a long time one of the standard treatments for low risk prostate cancer, with high rates of biochemical control and low levels of urinary and sexual late toxicity compared to other available techniques, namely external beam radiotherapy and radical prostatectomy. The aim of this article is to review the recent innovations of prostate brachytherapy, which suggest a bright future for the technique. We will discuss the extension of indications of permanent implant brachytherapy to favorable intermediate-risk patients, the use of novel isotopes such as Palladium 103 and Ces...
Source: Cancer Radiotherapie - May 29, 2018 Category: Cancer & Oncology Authors: Blanchard P, Graff-Cailleaud P, Bossi A Tags: Cancer Radiother Source Type: research

Endoluminal brachytherapy: Bronchus and oesophagus.
;ro L Abstract Endobronchial brachytherapy could be proposed in case of endoluminal tumours either as a palliative or a curative treatment. As a curative treatment, endobronchial brachytherapy could obtain a high local control rate in case of limited disease. In palliative setting, endobronchial brachytherapy improved thoracic symptoms in more than 80% of cases, but it is less efficient than external beam radiation therapy for palliation. It could be also proposed to maintain the airway open after laser therapy. Oesophageal brachytherapy is a valuable option as a palliative treatment, underused at this time. It ca...
Source: Cancer Radiotherapie - May 29, 2018 Category: Cancer & Oncology Authors: Hennequin C, Guillerm S, Wong S, Quéro L Tags: Cancer Radiother Source Type: research

Place of modern imaging in brachytherapy planning.
Abstract Imaging has probably been the most important driving force for the development of brachytherapy treatments the last 20 years. Due to implementation of three-dimensional imaging, brachytherapy is nowadays a highly accurate and reliable treatment option for many cancer patients. To be able to optimize the dose distribution in brachytherapy the anatomy and the applicator(s) or sources should be correctly localised in the images. For computed tomography (CT) the later criteria is easily fulfilled for most brachytherapy sites. However, for many sites, like cervix and prostate, CT is not optimal for delineation...
Source: Cancer Radiotherapie - May 29, 2018 Category: Cancer & Oncology Authors: Hellebust TP Tags: Cancer Radiother Source Type: research

Radiobiology of brachytherapy: The historical view based on linear quadratic model and perspectives for optimization.
acute;der C Abstract Most preclinical studies examining the radiobiology of brachytherapy have focused on dose rate effects. Scarcer data are available on other major parameters of therapeutic index, such as cell cycle distribution, repopulation or reoxygenation. The linear quadratic model describes the effect of radiotherapy in terms of normal tissue or tumour response. It allows some comparisons between various irradiation schemes. This model should be applied cautiously for brachytherapy, because it relies on cell death analysis only, and therefore partially reflects the biological effects of an irradiation. Mo...
Source: Cancer Radiotherapie - May 29, 2018 Category: Cancer & Oncology Authors: Chargari C, Van Limbergen E, Mahantshetty U, Deutsch É, Haie-Méder C Tags: Cancer Radiother Source Type: research

[Brachytherapy for head and neck cancers].
ard S Abstract The main indications of the brachytherapy of head and neck cancers are the limited tumours of the lip, the nose, the oral cavity and the oropharynx. Nasopharynx tumours are nowadays treated by intensity-modulated radiotherapy. This technique can be exclusive, associated with external radiotherapy or postoperative. It can also be a salvage treatment for the second primaries in previously irradiated areas. If the low dose rate brachytherapy rules remain the reference, the pulse dose rate technique allows the prescription of the dose rate and the optimisation of the dose distribution. Results of high d...
Source: Cancer Radiotherapie - May 29, 2018 Category: Cancer & Oncology Authors: Peiffert D, Coche-Dequéant B, Lapeyre M, Renard S Tags: Cancer Radiother Source Type: research

Total neoadjuvant therapy for rectal cancer.
Abstract While outcomes for patients with locally advanced disease have improved considerably with combined modality therapy, there is now an emphasis on developing risk-adapted treatment strategies. Moreover, the primary cause of death from locally advanced rectal cancer is related to distant progression, which now exceeds the rate of local failure. Thus, the necessity to optimally address micrometastatic disease has led to increasing interest in delivering chemotherapy in the neoadjuvant setting rather than in the postoperative setting. This review critically appraises the emerging literature on the options for ...
Source: Cancer Radiotherapie - May 25, 2018 Category: Cancer & Oncology Authors: Goodman KA Tags: Cancer Radiother Source Type: research

Multicatheter interstitial brachytherapy for breast cancer.
;v JM Abstract Brachytherapy remains the best irradiation technique to deliver a high dose in a small volume. Breast brachytherapy is part of the arsenal of therapy in the management of breast cancer. In this article, we present the technical data related to multicatheter interstitial brachytherapy to the breast proceeding, from the implantation of the vectors to the treatment itself. The indications for brachytherapy in breast cancer are boost after whole breast irradiation, accelerated partial breast irradiation or selected patients with second ipsilateral breast tumor event. The results in terms of efficacy and...
Source: Cancer Radiotherapie - May 23, 2018 Category: Cancer & Oncology Authors: Sumodhee S, Strnad V, Hannoun-Lév JM Tags: Cancer Radiother Source Type: research

[New calculation algorithms in brachytherapy for iridium 192 treatments].
Abstract Since 1995, the brachytherapy dosimetry protocols follow the methodology recommended by the Task Group 43. This methodology, which has the advantage of being fast, is based on several approximations that are not always valid in clinical conditions. Model-based dose calculation algorithms have recently emerged in treatment planning stations and are considered as a major evolution by allowing for consideration of the patient's finite dimensions, tissue heterogeneities and the presence of high atomic number materials in applicators. In 2012, a report from the American Association of Physicists in Medicine Ra...
Source: Cancer Radiotherapie - May 18, 2018 Category: Cancer & Oncology Authors: Robert C, Dumas I, Martinetti F, Chargari C, Haie-Meder C, Lefkopoulos D Tags: Cancer Radiother Source Type: research

[Why is brachytherapy still essential in 2017?]
ari C Abstract These recent years, brachytherapy has benefited from imaging modalities advances. A more systematic use of tomodensitometric, ultrasonographic and MRI images during brachytherapy procedures has allowed an improvement in target and organs at risk assessment as well as their relationship with the applicators. New concepts integrating tumor regression during treatment have been defined and have been clinically validated. New applicators have been developed and are commercially available. Optimization processes have been developed, integrating hypofractionation modalities leading to tumor control improv...
Source: Cancer Radiotherapie - May 16, 2018 Category: Cancer & Oncology Authors: Haie-Méder C, Maroun P, Fumagalli I, Lazarescu I, Dumas I, Martinetti F, Chargari C Tags: Cancer Radiother Source Type: research

Renaud Mazeron: A great scientist and teacher who contributed to GEC ESTRO for a decade. Tribute to Dr. Renaud Mazeron (1977-2016).
degaard J PMID: 29778451 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 16, 2018 Category: Cancer & Oncology Authors: Nout R, Kirisits C, Tanderup K, Pötter R, Haie-Méder C, Pieters B, Lindegaard J Tags: Cancer Radiother Source Type: research

Pharmacological modulation of radiation-induced oral mucosal complications.
The objective of this article was to review the latest updates in the management of radiation-induced mucositis, with a focus on pharmaceutical strategies for the prevention or treatment of mucositis. Although numerous studies analysing the prevention and management of oral radiation-induced mucositis have been conducted, there are still few reliable data to guide daily clinical practice. Furthermore, most of the tested drugs have shown no (anti-inflammatory cytokine, growth factors) or limited (palifermin) effect. Therapies for acute oral mucositis are predominantly focused on improving oral hygiene and providing symptoms...
Source: Cancer Radiotherapie - May 15, 2018 Category: Cancer & Oncology Authors: Bockel S, Vallard A, Lévy A, François S, Bourdis M, Le Gallic C, Riccobono D, Annede P, Drouet M, Tao Y, Blanchard P, Deutsch É, Magné N, Chargari C Tags: Cancer Radiother Source Type: research

3D brachytherapy for cervical cancer: New optimization ways.
ari C Abstract Brachytherapy has known major improvements in recent decades. It represents an essential component of local treatment of cervix cancers. One major breakthrough was the advent of 3D imaging for image-guided brachytherapy. Doses could be prescribed to volumes. This allows better delineation and coverage of target volumes, as well as organs at risk (bladder, rectum, sigmoid) protection. Local recurrences have been consequently reduced and survival has been improved. In addition, improvement and development of new applicators have facilitated the delivery of interstitial treatments. Afterloading applica...
Source: Cancer Radiotherapie - May 15, 2018 Category: Cancer & Oncology Authors: Fumagalli I, Haie-Méder C, Chargari C Tags: Cancer Radiother Source Type: research

[Brachytherapy: The most ancient of modern radiation techniques].
der C PMID: 29773472 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 14, 2018 Category: Cancer & Oncology Authors: Chargari C, Maingon P, Mornex F, Haie-Méder C Tags: Cancer Radiother Source Type: research

[Base of the skull meningioma: Efficacy, clinical tolerance and radiological evaluation after radiotherapy].
l G Abstract Skull base meningioma leads to functional disturbances, which can significantly alter the quality of life. The optimal management of these lesions, whose goals are neurological preservation and tumour local control, is not yet clearly established. It is widely recognized that the goal of a radical excision should be abandoned despite the advances in the field of microsurgery of skull base lesions. Although less morbid, partial tumour excision would be associated with increased risk of local tumour recurrence. Although discussed both exclusive and adjuvant have proven to be highly successful in terms o...
Source: Cancer Radiotherapie - May 14, 2018 Category: Cancer & Oncology Authors: Brahimi Y, Antoni D, Srour R, Proust F, Cebula H, Labani A, Noël G Tags: Cancer Radiother Source Type: research

[Advances in the management of cervical lymphadenopathies of unknown primary with intensity modulated radiotherapy: Doses and target volumes].
iat J Abstract The definition of nodal and/or mucosal target volumes for radiation therapy for lymphadenopathies of unknown primary is controversial. Target volumes may include all nodal areas bilaterraly and be pan-mucosal or unilateral, selective, including the sole oropharyngeal mucosa. This review presents current recommendations in light of changes in the TNM classification, Human papillomavirus status and therapeutic advances. We conducted a systematic review of the literature with the following keywords: lymphadenopathy; head and neck; unknown primary and radiation therapy. There are no direct comparative s...
Source: Cancer Radiotherapie - May 3, 2018 Category: Cancer & Oncology Authors: Troussier I, Klausner G, Blais E, Giraud P, Lahmi L, Pflumio C, Faivre JC, Geoffrois L, Babin E, Morinière S, Maingon P, Thariat J Tags: Cancer Radiother Source Type: research

Adaptive radiotherapy for head and neck cancers: Fact or fallacy to improve therapeutic ratio?
Abstract Modern standards of precision radiotherapy, primarily driven by the technological advances of intensity modulation and image guidance, have led to increased versatility in radiotherapy planning and delivery. The ability to shape doses around critical normal organs, while simultaneously "painting" boost doses to the tumor have translated to substantial therapeutic gains in head and neck cancer patients. Recently, dose adaptation (or adaptive radiotherapy) has been proposed as a novel concept to enhance the therapeutic ratio of head and neck radiotherapy, facilitated in part by the onset of molecu...
Source: Cancer Radiotherapie - April 23, 2018 Category: Cancer & Oncology Authors: Li YQ, Tan JSH, Wee JTS, Chua MLK Tags: Cancer Radiother Source Type: research

[Radiotherapy of primary breast sarcomas: Retrospective study].
CONCLUSION: Due to the rarity of this entity and the absence of randomized trials, evidence based management is still lacking. However, a multidisciplinary approach is to be required including surgical excision followed by radiotherapy, depending on the tumour characteristics. PMID: 29680464 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 18, 2018 Category: Cancer & Oncology Authors: Chellakhi M, Benchakroun N, Bouchbika Z, Jouhadi H, Tawfiq N, Sahraoui S, Benider A Tags: Cancer Radiother Source Type: research

Trimodalities for bladder cancer in elderly: Transurethral resection, hypofractionated radiotherapy and gemcitabine.
CONCLUSION: Hypofractionated radiotherapy and gemcitabine as a radiosensitizer in elderly as organ preservation for transitional cell carcinoma bladder cancer have acceptable toxicity profile with good response rate and disease-free survival, keeping salvage cystectomy for persistence or recurrence of invasive cancer. PMID: 29678595 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 17, 2018 Category: Cancer & Oncology Authors: Mohamed HAH, Salem MA, Elnaggar MS, Gabr A, Abdelrheem AM Tags: Cancer Radiother Source Type: research

Evaluation of acute skin toxicity of breast radiotherapy using thermography: Results of a prospective single-centre trial.
Abstract PURPOSE: Radiotherapy is a common adjuvant treatment of breast cancer. Acute radiation-induced dermatitis is a frequent side effect. We hypothesized whether it is possible to capture the increase of local temperature as a surrogate of the inflammatory state induced by radiotherapy. We designed a prospective, observational, single-centre study to acquire data on temperature rise in the treated breast during the course of radiotherapy, establish a possible association with the occurrence of dermatitis and investigate the predictive value of temperature increase in future occurrences of radiation-induced der...
Source: Cancer Radiotherapie - April 17, 2018 Category: Cancer & Oncology Authors: Maillot O, Leduc N, Atallah V, Escarmant P, Petit A, Belhomme S, Sargos P, Vinh-Hung V Tags: Cancer Radiother Source Type: research

Metastatic mediastinal mature teratoma with malignant transformation in a young man with an adenocarcinoma in a Klinefelter's syndrome: Case report and review of the literature.
ël G Abstract Malignant transformation of mediastinal mature teratoma is extremely rare and worsens the prognosis of the disease. Transformation can appear synchronously to or several years after the initial diagnosis. Clinical and radiological signs can orientate the clinician but the definitive diagnosis is obtained thanks to histology. An 11 year-old boy presented with a mediastinal mature teratoma and bone and pulmonary metastases. He received six cycles of chemotherapy combining etoposide, ifosfamide, cisplatin, followed by resection of a 16×14×9cm mediastinal mass. Karyotype analysis reveale...
Source: Cancer Radiotherapie - April 16, 2018 Category: Cancer & Oncology Authors: Le Fèvre C, Vigneron C, Schuster H, Walter A, Marcellin L, Massard G, Lutz P, Noël G Tags: Cancer Radiother Source Type: research

Unusual occurrence reporting system: Sharing a ten years experience from a tertiary care JCIA accredited university hospital.
CONCLUSIONS: The ten years experience with reporting and documenting of unusual occurrences resulted in a safety culture where every individual is willing to share any type of incident with a free well. Our experience at the Aga Khan University Hospital (AKUH) shows that the major reason for the occurrence of incidents was oversight. The majority of unusual occurrences were reported by radiation therapy technologists, as expected, since they handle the bulk of the treatment planning process. PMID: 29661502 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 13, 2018 Category: Cancer & Oncology Authors: Hussain A, Khan Y, Ali N, Jangda AQ, Siddiqui S, Muhammad W, Khan Z, Abbasi AN, Rehman L, Yousuf A Tags: Cancer Radiother Source Type: research

Breast lymphoma occurring after an invasive ductal breast carcinoma developed in the same area: A case report and literature review.
iot S Abstract Chemo- and radiotherapy are treatments very helpful to cure cancers but are also well known for adverse effects such as secondary cancers. Breast cancers following Hodgkin lymphoma have been relatively well studied. Breast cancers after radiotherapy covering or nearby breasts or nipples are usually carcinomas or secondary sarcomas. Among the big cohort of patients treated for breast carcinomas, breast lymphomas developed in the same area are not usual. Nevertheless, published studies described a significant increased risk of non-Hodgkin lymphoma after initial radiotherapy for a solid cancer. Here, w...
Source: Cancer Radiotherapie - April 12, 2018 Category: Cancer & Oncology Authors: Demoor-Goldschmidt C, Mahé MA, Supiot S Tags: Cancer Radiother Source Type: research

TPF induction chemotherapy followed by concurrent chemoradiotherapy for locally advanced nasopharyngeal carcinoma: Long term results of a Tunisian series.
CONCLUSION: Our results, in this field of study, are encouraging with acceptable toxicity despite the lack of intensity-modulated radiotherapy technique in our institution during the period of study. PMID: 29650387 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 9, 2018 Category: Cancer & Oncology Authors: Toumi N, Ben Kridis W, Mnejja W, Bouzguenda R, Khanfir A, Ghorbel A, Daoud J, Frikha M Tags: Cancer Radiother Source Type: research

Evaluation at 3  years of concurrent bevacizumab and radiotherapy for breast cancer: Results of a prospective study.
CONCLUSIONS: Concurrent bevacizumab with locoregional radiotherapy is associated with acceptable 3-years toxicity in patients with breast cancer. PMID: 29650388 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 9, 2018 Category: Cancer & Oncology Authors: Dautruche A, Belin L, Cottu P, Bontemps P, Lemanski C, de la Lande B, Baumann P, Missohou F, Lévy C, Peignaux K, Reynaud-Bougnoux A, Denis F, Gobillion A, Pernin V, Kirova Y Tags: Cancer Radiother Source Type: research

[Inflammatory and immune biomarkers of radiation response].
Abstract In radiotherapy, the treatment is adapted to each individual to protect healthy tissues but delivers most of time a standard dose according to the tumor histology and site. The only biomarkers studied to individualize the treatment are the HPV status with radiation dose de-escalation strategies, and tumor hypoxia with dose escalation to hypoxic subvolumes using FMISO- or FAZA-PET imaging. In the last decades, evidence has grown about the contribution of the immune system to radiation tumor response. Many preclinical studies have identified some of the mechanisms involved. In this context, we have realised...
Source: Cancer Radiotherapie - April 9, 2018 Category: Cancer & Oncology Authors: Nesseler JP, Schaue D, McBride WH, Nickers P Tags: Cancer Radiother Source Type: research

(18F)-FDG PET/CT parameters to predict survival and recurrence in patients with locally advanced cervical cancer treated with chemoradiotherapy.
Abstract PURPOSE: To identify predictive (18F)-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT)-based parameters for locoregional control, disease-free survival and overall survival, by testing different thresholds of metabolic tumor volume and total lesion glycolysis in patients with locally-advanced cervical cancer. PATIENTS AND METHODS: Thirty-seven patients treated with standard chemoirradiation underwent a pretreatment (18F)-FDG-PET/CT. Using different thresholds of maximum standardized uptake value, the following PET parameters were computed: maximum standardized upta...
Source: Cancer Radiotherapie - April 9, 2018 Category: Cancer & Oncology Authors: Scher N, Castelli J, Depeursinge A, Bourhis J, Prior JO, Herrera FG, Ozsahin M Tags: Cancer Radiother Source Type: research

[Evaluation of an automatic delineation system for organs at risk and target lymph nodes volumes for patients treated for breast cancer].
CONCLUSIONS: For patients with breast cancer, the system for automatic delineation and segmentation Workflow Box (Mirada Medical, UK) permitted to safely shorten the time for delineation with acceptable organs at risk delineation. Improvement of lymph node volumes is needed. A new evaluation will be realized after using the system in routine practice. PMID: 29628204 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 5, 2018 Category: Cancer & Oncology Authors: Arsène-Henry A, Xu HP, Robilliard M, El Amine W, Costa É, Kirova YM Tags: Cancer Radiother Source Type: research

Dose constraints for moderate hypofractionated radiotherapy for prostate cancer: The French genito-urinary group (GETUG) recommendations.
uin C Abstract Considering recent phase III trials results, moderate hypofractionated radiotherapy can be considered as a standard treatment for low and intermediate risk prostate cancer management. This assessment call for a framework allowing homogeneous and reproducible practices in the different centers using this radiotherapy schedule. The French Genito-Urinary Group (GETUG) provides here recommendations for daily practice of moderate hypofractionated radiotherapy for prostate cancer, with indications, dose, fractionation, pre-treatment planning, volume of interest delineation (target volume and organs at ris...
Source: Cancer Radiotherapie - April 5, 2018 Category: Cancer & Oncology Authors: Langrand-Escure J, de Crevoisier R, Llagostera C, Créhange G, Delaroche G, Lafond C, Bonin C, Bideault F, Sargos P, Belhomme S, Pasquier D, Latorzeff I, Supiot S, Hennequin C Tags: Cancer Radiother Source Type: research

Intraluminal brachytherapy boost following external beam radiotherapy with concurrent chemotherapy of oesophagus carcinoma: Results of a prospective observational study.
CONCLUSIONS: With the concept that high tumoricidal dose for adequate tumor control achieved by intraluminal brachytherapy as a mean of dose escalation, while sparing surrounding normal tissue and potentially improving therapeutic ratio, external beam radiotherapy followed by intraluminal brachytherapy could be a better choice for oesophagus carcinoma. PMID: 29615371 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 31, 2018 Category: Cancer & Oncology Authors: Nag P, Gurjar OP, Bhandari V, Gupta KL, Bagdare P, Goyal H Tags: Cancer Radiother Source Type: research

Proton beam therapy for the management of mediastinal Hodgkin lymphoma in a young female patient.
PMID: 29606542 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 29, 2018 Category: Cancer & Oncology Authors: Meyer E, Goudjil F, Tamburini J, Dendale R, Kirova Y Tags: Cancer Radiother Source Type: research

[Radiotherapy of bone metastases in France: A descriptive monocentric retrospective study].
The objective of this study was to compare the current practices of a French radiotherapy department for the treatment of uncomplicated bone metastases with data from the literature in order to improve and optimize the management of patients. MATERIAL AND METHODS: A retrospective monocentric study of patients who underwent palliative irradiation of uncomplicated bone metastases was performed. RESULTS: Ninety-one patients had 116 treatments of uncomplicated bone metastases between January 2014 and December 2015, including 44 men (48%) and 47 women (52%) with an average age of 63years (25-88years). Primary tumours ...
Source: Cancer Radiotherapie - March 27, 2018 Category: Cancer & Oncology Authors: Le Fèvre C, Antoni D, Thiéry A, Keller A, Truntzer P, Vigneron C, Clavier JB, Guihard S, Pop M, Schumacher C, Salze P, Noël G Tags: Cancer Radiother Source Type: research

Hippocampal sparing in stereotactic radiotherapy for brain metastases: To contour or not contour the hippocampus?
Abstract PURPOSE: The aim of our study was to evaluate hippocampal irradiation in patients treated with fractionated stereotactic brain radiotherapy. PATIENTS AND METHODS: Retrospective hippocampal dosimetric analysis performed on 22 patients with one to four brain metastases treated with fractionated stereotactic radiotherapy using volumetric intensity-modulated arc therapy. Original plans did not include hippocampus as avoidance structure in optimization criteria; hippocampus was retrospectively delineated on magnetic resonance coregistered with planning CT and using as reference the RTOG 0933 atlas. Hippoc...
Source: Cancer Radiotherapie - March 22, 2018 Category: Cancer & Oncology Authors: Di Carlo C, Trignani M, Caravatta L, Vinciguerra A, Augurio A, Perrotti F, Di Tommaso M, Nuzzo M, Giancaterino S, Falco MD, Genovesi D Tags: Cancer Radiother Source Type: research

Pre- and postoperative radiotherapy for extremity soft tissue sarcoma: Evaluation of inter-observer target volume contouring variability among French sarcoma group radiation oncologists.
CONCLUSION: Accurate delineation of target volume appears to be a crucial element to ensure multicenter clinical trial quality assessment, reproducibility and homogeneity in delivering RT. radiation therapy RT. Quality assessment process should be proposed in this setting. We have shown in our study that preoperative radiation therapy of extremity soft tissue sarcoma has less inter-observer contouring variability. PMID: 29545115 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - March 12, 2018 Category: Cancer & Oncology Authors: Sargos P, Charleux T, Haas RL, Michot A, Llacer C, Moureau-Zabotto L, Vogin G, Le Péchoux C, Verry C, Ducassou A, Delannes M, Mervoyer A, Wiazzane N, Thariat J, Sunyach MP, Benchalal M, Laredo JD, Kind M, Gillon P, Kantor G Tags: Cancer Radiother Source Type: research

Phyllodes tumors of the breast: The British Columbia Cancer Agency experience.
Abstract PURPOSE: Phyllodes tumors of the breast are uncommon fibroepithelial lesions for which optimal management remains unclear. This retrospective population-based study reports treatment and outcomes for patients with phyllodes tumors and evaluates characteristics that influence outcome. MATERIALS AND METHODS: Data were analysed on 183 patients with newly diagnosed phyllodes tumors from 1999 to 2014. Five-year Kaplan-Meier local recurrence and survival were compared between cohorts with benign (n=83), borderline (n=50) and malignant phyllodes tumor (n=49) histology. RESULTS: Median (range) follow-up...
Source: Cancer Radiotherapie - March 7, 2018 Category: Cancer & Oncology Authors: Rodrigues MF, Truong PT, McKevitt EC, Weir LM, Knowling MA, Wai ES Tags: Cancer Radiother Source Type: research

Radiotherapy of relapse-refractory follicular lymphoma.
CONCLUSION: For relapsed and refractory follicular lymphoma, external beam radiotherapy should be considered as an effective modality when integrated in a multimodality approach. Randomised studies are warranted to validate this strategy. PMID: 29477304 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - February 21, 2018 Category: Cancer & Oncology Authors: Grignano É, Deau-Fischer B, Loganadane G, Breton M, Burroni B, Bouscary D, Kirova YM Tags: Cancer Radiother Source Type: research

[Adjuvant contact radiotherapy for conjunctival malignancies: Preliminary results of a series of 14 patients treated with the Papillon 50 machine].
CONCLUSION: Adjuvant contact radiotherapy provides a good local control after resection of conjunctival malignancies (melanoma, malignant histiocytofibroma, carcinoma). Thanks to its precision, this technique is well tolerated with a low rate of complications. Furthermore, it is delivered on an ambulatory basis. PMID: 29475731 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - February 20, 2018 Category: Cancer & Oncology Authors: Coquard R, N'Guyen AM, Mathis T, Josserand-Pietri F, Khodri M, Largeron G, Barbet N, Grange JD Tags: Cancer Radiother Source Type: research