[Management of patients with pacemakers or implantable cardioverter defibrillator undergoing radiotherapy].
dux C Abstract An increasing number of patients with cardiac implantable electronic devices benefit from radiotherapy, warranting specific collaborative management between both radiation oncologists and cardiologists. Interactions between electromagnetic fields, secondary particles and cardiac implantable electronic devices may result in transient and reversible malfunctions with significant consequences depending on the underlying cardiac pathology and the level of patient's cardiac implantable electronic devices dependency. Numerous international guidelines on patients' management have been proposed and all agre...
Source: Cancer Radiotherapie - August 25, 2018 Category: Cancer & Oncology Authors: Huertas A, Thuillot M, Bibault JE, Sharifzadehgan A, Laurans M, Giraud P, Lavergne T, Marijon É, Durdux C Tags: Cancer Radiother Source Type: research

[AFQSR: A concrete and active implication in the service of the radiotherapy in 2018].
Abstract AFQSR has demonstrated, since its creation, its dynamism, by participating in many working groups with the health authorities and national societies and by helping to ensure that quality, through the voice of the quality experts, constitutes a way to progress in the practice and exercise of radiotherapy. PMID: 30150088 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 24, 2018 Category: Cancer & Oncology Authors: Ponsard N Tags: Cancer Radiother Source Type: research

[Modalities and advantages of image guided radiation therapy of breast cancer in adjuvant setting].
Abstract In adjuvant setting, breast cancer radiotherapy volumes include whole mammary gland or chest wall, and when indicated, nodal area such as axilla, supraclavicular, and internal mammary chain. An accurate patients positioning is required due to some geometric complexity of target volumes closed to organs at risk as heart and lung. Image guided radiation therapy allows such accuracy. Here we propose a review on image guided radiotherapy for breast cancer. PMID: 30145089 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 22, 2018 Category: Cancer & Oncology Authors: Kammerer E, Fenoglietto P, Bourgier C Tags: Cancer Radiother Source Type: research

[The major debate: Micrometastases and breast cancer  - To be for nodal irradiation].
[The major debate: Micrometastases and breast cancer - To be for nodal irradiation]. Cancer Radiother. 2018 Aug 22;: Authors: Bourgier C, Lemanski C, Fenoglietto P, Azria D Abstract Standard of care in breast cancer management is well-defined. However, some gray zones still exist, in particular adjuvant radiotherapy indications in case of pN1mi breast cancer. Here we propose to define their prognosis, to underpin the benefit of adjuvant treatments in such patients' management and to define lymphedema risk, which is the most common late side effect of locoregional treatments. PMID: 30145...
Source: Cancer Radiotherapie - August 22, 2018 Category: Cancer & Oncology Authors: Bourgier C, Lemanski C, Fenoglietto P, Azria D Tags: Cancer Radiother Source Type: research

[Surgery or radiotherapy for oropharyngeal HPV-positive tumours?]
iat J Abstract Oropharyngeal carcinomas related to the human papilloma virus (HPV; usually HPV16) exhibit biological differences in terms of carcinogenesis and are of relatively better prognosis (in the absence of tobacco consumption) compared to tobacco-related cancers. The therapeutic strategies between these two forms of cancers of the upper aerodigestive tract related to different risk factors are however identical, except therapeutic trial. In the absence of a sufficient level of evidence to define a specific strategy for induced HPV carcinomas, the analysis of the recent literature nonetheless allows us to s...
Source: Cancer Radiotherapie - August 22, 2018 Category: Cancer & Oncology Authors: Philouze P, Céruse P, Thariat J Tags: Cancer Radiother Source Type: research

[Hypofractionnated radiotherapy for elderly patients with prostate cancer].
iot S Abstract Radiation therapy technique and schedules could be adapted to patient's age because of a natural history of prostate cancer perceived as different, taking into account the comorbidities of patients but also a particular tolerance of elderly subjects. Thus, in localized prostate cancer, evaluation of associated diseases is essential before considering a treatment that will be of interest only if the life expectancy is greater than 10 years. When a curative approach is decided, radiotherapy holds a place of choice. Due to the recent results of randomized studies evaluating moderate hypofractionnated r...
Source: Cancer Radiotherapie - August 22, 2018 Category: Cancer & Oncology Authors: Sargos P, Créhange G, Hennequin C, Latorzeff I, de Crevoisier R, Roubaud G, Supiot S Tags: Cancer Radiother Source Type: research

[Image-guided radiotherapy contribution and patient setup for anorectal cancer treatment].
Abstract Intensity-modulated radiation therapy is recommended in anal squamous cell carcinoma treatment and is increasingly used in rectal cancer. It adapts the dose to target volumes, with a high doses gradient. Intensity-modulated radiation therapy allows to reduce toxicity to critical normal structures and to consider dose-escalation studies or systemic treatment intensification. Image-guided radiation therapy is a warrant of quality for intensity-modulated radiation therapy, especially for successful delivery of the dose as planned. There is no recommended international or national anorectal cancer image-guide...
Source: Cancer Radiotherapie - August 21, 2018 Category: Cancer & Oncology Authors: Masson I, Delpon G, Vendrely V Tags: Cancer Radiother Source Type: research

[Hypofractionated radiotherapy for breast cancer in elderly patients: current evidence and future perspectives].
Abstract Adjuvant radiotherapy is the pillar of breast conserving surgery. Its omission is related with a higher risk of local recurrence and of breast cancer related or non-related mortality. It is of paramount importance to guarantee this treatment is fully administered to all patients after breast conserving surgery, including the elderly. In the last three decades several hypofractionated treatment schemes have shown their non-inferiority, allowing for treatment time reduction facilitating adhesion to treatment and reducing radiotherapy burden. This review focuses on the schemes and indications which have been...
Source: Cancer Radiotherapie - August 21, 2018 Category: Cancer & Oncology Authors: Rivin Del Campo E, Rivera S Tags: Cancer Radiother Source Type: research

[Image-guided radiotherapy for head and neck carcinoma].
Abstract Intensity-modulated radiotherapy, combined with chemotherapy, is the recommended treatment of locally advanced head and neck carcinoma, as a definitive treatment or as an adjuvant treatment following surgery. This technique offers the ability to sculpt the dose closely to the tumor volume. With this close conformity, it is essential to ensure that every day during the treatment the patient position and anatomy are similar to those at the time of treatment planning. Inevitably, there will be uncertainties introduced in this process and a planning target volume margins are added around the tumour volume to ...
Source: Cancer Radiotherapie - August 21, 2018 Category: Cancer & Oncology Authors: Beddok A, Blanchard P Tags: Cancer Radiother Source Type: research

The sentinel lymph node of breast cancer and the radiation oncologist.
;ro L Abstract If the indications of sentinel lymph node biopsy and axillary lymph node dissection have been the subject of many trials, the indications of radiotherapy, in the absence of axillary lymph node dissection are a matter of debate. We reviewed the available literature on this topic and tried to draw some practical applications. In case of negative result of a sentinel lymph node biopsy, patients could be viewed as having pN0 disease and indications of adjuvant radiotherapy based on this paradigm. However, when the result of a sentinel lymph node biopsy was positive and no axillary lymph node dissection ...
Source: Cancer Radiotherapie - August 20, 2018 Category: Cancer & Oncology Authors: Hennequin C, Guillerm S, Quéro L Tags: Cancer Radiother Source Type: research

[Analysis of immune microenvironment by multiplex immunohistochemistry in locally advanced non-small cell lung cancer: Principles and perspectives].
This article describes the potential of these assays in locally advanced non-small cell lung cancer. PMID: 30131267 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 18, 2018 Category: Cancer & Oncology Authors: Boulle G, Velut Y, Boni A, Lupo A, Alifano M, Trédaniel J, Giraud P, Damotte D Tags: Cancer Radiother Source Type: research

[Interest of image-guided radiotherapy for brain tumors and positioning control].
eneix S, Laprie A Abstract A narrow therapeutic index and more and more patients with long survival characterize primary and second brain tumors. Image-guided radiotherapy can increase accuracy of the patient's position during a course of intracranial irradiation thanks to a direct or indirect visualization of targets volumes. Treatment reproducibility and organ at risk-sparing are the primary issues, particularly with the development of stereotactic radiotherapy and protontherapy. Regarding intracranial treatments, image-guided radiotherapy seems to be a repetitive task based on skeletal structures registration. ...
Source: Cancer Radiotherapie - August 18, 2018 Category: Cancer & Oncology Authors: Legouté F, Padovani L, Claude L, Bolle S, Attal J, Gonzalez-Moya A, Lizée T, Paumier A, Jadaud É, Pointreau Y, Dufreneix S, Laprie A Tags: Cancer Radiother Source Type: research

[Circulating tumour DNA: Current detection methods, use in radiotherapy and future development].
et JB Abstract Recent technological developments enable the detection and quantification of circulating tumour DNA in the blood, with potentially major clinical implications, particularly for cancers treated with curative intent. Circulating tumour DNA has a potential impact before, during and after treatment. If limitations of this approach remain, requiring further development, it is important to know the principles and applications in view of the potential impact on the clinical practice. In this review, we will discuss the current detection methods, then the place of circulating tumour DNA in oncology and more...
Source: Cancer Radiotherapie - August 18, 2018 Category: Cancer & Oncology Authors: Castelli J, Cabel L, Bidard FC, Duvergé L, Bachet JB Tags: Cancer Radiother Source Type: research

[Image-guided radiotherapy for gynaecological cancer].
In this study, we review the different techniques of image-guided radiotherapy and the perspective of adaptive radiotherapy. PMID: 30126771 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 17, 2018 Category: Cancer & Oncology Authors: Lucia F, Schick U, Pradier O, Espenel S, de Crevoisier R, Chargari C Tags: Cancer Radiother Source Type: research

[Information security in a radiotherapy centre: Controlling risks to better cope with them].
Abstract The dematerialization of data, the multiplication of sharing and exchanges between professionals, the increase of business software offer (patient files, human resources management, financial management, document management, etc.) question us about the security of information systems. This protection contributes to the quality of the care of patients in respect of their rights, to ensure the confidentiality, traceability and sustainability of digital personal health data and to strengthen the confidence of professionals in the system and its uses. But what security procedures are currently being undertake...
Source: Cancer Radiotherapie - August 17, 2018 Category: Cancer & Oncology Authors: Guerrier B Tags: Cancer Radiother Source Type: research

[Hypofractionad radiotherapy for elderly with head and neck cancer].
Abstract Thirty percent of patients with head and neck cancer are over 70 years. Radiotherapy approach in elderly is a challenge. On one hand, radiotherapy side effects, as well as the number of sessions required, could be a burden. On the other hand, omission of local treatment is not an option due to the symptoms of the tumor. Patients in good general condition may receive standard fractionnated radiotherapy. For frail patients unsuitable for standard fractionated radiotherapy, more convenient shorter course of radiotherapy are commonly used. Physicians have to choose the best radiotherapy schedule according to ...
Source: Cancer Radiotherapie - August 11, 2018 Category: Cancer & Oncology Authors: Ortholan C, Auperin A, Mertens C, Le Caer H, Guigay J Tags: Cancer Radiother Source Type: research

[Image-guided radiotherapy in lung cancer].
Abstract Image-guided radiotherapy takes place at every step of the treatment in lung cancer, from treatment planning, with fusion imaging, to daily in-room repositioning. Managing tumoral and surrounding thoracic structures motion has been allowed since the routine use of 4D computed tomography (4DCT). The integration of respiratory motion has been made with "passive" techniques based on reconstruction images from 4DCT planning, or "active" techniques adapted to the patient's breathing. Daily repositioning is based on regular images, weekly or daily, low (kV) or high (MV) energy. MRI and funct...
Source: Cancer Radiotherapie - August 10, 2018 Category: Cancer & Oncology Authors: Aboudaram A, Khalifa J, Massabeau C, Simon L, Hadj Henni A, Thureau S Tags: Cancer Radiother Source Type: research

[Image guided radiation therapy for prostate cancer; how, when and why?]
Abstract Novel techniques of prostate cancer radiotherapy require increased precision, which is allowed by Image Guided Radiation Therapy (IGRT), using fiducial markers and orthogonal radiographs, cone beam computed tomography, magnetic resonance imaging, ultrasound, and/or transponders. IGRT may reduce the toxicity of radiation therapy, but there is no clear recommendation on the best IGRT technique and how often it should be applied. PMID: 30100124 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 9, 2018 Category: Cancer & Oncology Authors: Escande A, Supiot S Tags: Cancer Radiother Source Type: research

[Recent data in cervical cancer: Radiation oncologist's perspective].
Abstract During the recent past years, the therapeutic management of locally advanced cervical cancer patients has consistently improved, with the integration of image guided brachytherapy and dose escalation strategies leading to an improvement of local control rates. In parallel, the evolution of external beam radiotherapy techniques and the better control of organs at risk doses in brachytherapy have contributed to decrease the probability of severe normal tissue complication. In case of advanced disease, patients prognosis remains however marked by a high risk of distant failure, and this finding has encourage...
Source: Cancer Radiotherapie - August 9, 2018 Category: Cancer & Oncology Authors: Chargari C, Gouy S, Pautier P, Haie-Meder C Tags: Cancer Radiother Source Type: research

[Role of radiation therapy in the management of pancreatic cancer].
Abstract At diagnosis, about 15% of patients with pancreatic cancer present with a resectable tumour, 50% have a metastatic tumour, and 25% a locally advanced tumor (non-metastatic but unresectable due to vascular invasion) or borderline resectable. Despite the technical progress made in the field of radiation therapy and the improvement of the efficacy of chemotherapy, the prognosis of these patients remains very poor. Recently, the role of radiation therapy in the management of pancreatic cancer has been much debated. This review aims to evaluate the role of radiation therapy for these patients. PMID: 30100...
Source: Cancer Radiotherapie - August 9, 2018 Category: Cancer & Oncology Authors: Huguet F, Rivin Del Campo E, Antoni D, Vendrely V, Hammel P Tags: Cancer Radiother Source Type: research

[Hodgkin lymphoma and target definition guidelines].
Abstract Treatment for stage I and II Hodgkin lymphoma is based on a combination of chemotherapy and radiotherapy, with a high successful cure rate. Now, the aim is to decrease toxicity rates. Positron-emission tomography scan is recommended as pretreatment baseline and is very useful to define precisely target volumes for planning radiation therapy. Based on these changes were developed guidelines for modern radiation therapy called involved node and « involved site ». PMID: 30093312 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 6, 2018 Category: Cancer & Oncology Authors: Peignaux K, Gonzague-Casabianca L Tags: Cancer Radiother Source Type: research

[New developments in the management of nasopharyngeal carcinoma].
This article summarizes the recent advances in nasopharyngeal cancer diagnosis, classification, treatment, surveillance and management of recurrences. Chemotherapy timing is discussed, along with arguments in favor of induction chemotherapy in locally advanced cases. As a survival advantage has been suggested for when patients are treated in high volume center it seems reasonable to refer these young patients for treatment to tertiary expert centers, especially given the low incidence of the disease. PMID: 30087054 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 4, 2018 Category: Cancer & Oncology Authors: Blanchard P, Nguyen F, Moya-Plana A, Pignon JP, Even C, Bidault F, Temam S, Ruffier A, Tao Y Tags: Cancer Radiother Source Type: research

[Radiotherapy for HIV-infected patients].
no JP Abstract Since the advent of highly active antiretroviral therapy, cancer incidence is still 2 to 3-fold higher in patients infected by human immunodeficiency virus (HIV) than in the general population, with an increased incidence of malignancies not associated with acquired immunodeficiency syndrome (AIDS). HIV-infected patients cancer treatment does not differ from that in the general population. However, the management of those patients have some particularities due to preexisting comorbid conditions, including metabolic, cardiovascular, renal or hepatic complications and the risk for potential drug - dru...
Source: Cancer Radiotherapie - August 4, 2018 Category: Cancer & Oncology Authors: Quéro L, Gobert A, Spano JP Tags: Cancer Radiother Source Type: research

[Editorial].
PMID: 30082201 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 3, 2018 Category: Cancer & Oncology Authors: Deutsch E, Le groupe TEP-RT Tags: Cancer Radiother Source Type: research

[Radionecrosis following stereotactic radiotherapy of a 3-cm brain metastasis: Can we improve the dosimetric results?]
We report the case of a 30-mm brain metastases treated with stereotactic radiotherapy after initial whole brain radiotherapy, complicated with symptomatic radionecrosis. A dose of 24Gy in three fractions on the 80% isodose were delivered using a dynamic conformal arc technique (Novalis TX®). We realized a dosimetric comparison with: (i) optimization of initial conformal arc plan, (ii) volumetric modulated arctherapy with coplanar arcs and (iii) volumetric modulated arctherapy with coplanar and non-coplanar arcs. The optimal dose planning in terms of planning target volume coverage (99.2%) and normal brain sparing (V24G...
Source: Cancer Radiotherapie - August 2, 2018 Category: Cancer & Oncology Authors: Brun L, Dupic G, Chassin V, Verrelle P, Lapeyre M, Biau J Tags: Cancer Radiother Source Type: research

[Radiation therapy planning for Hodgkin lymphoma: Focus on intensity-modulated radiotherapy, gating, protons. Which techniques to best deliver radiation?]
zar F Abstract The optimization of radiotherapy in these young and long-lived survivors raises the question about the interest of using modern techniques to allow a better distribution of the dose. The choice of the irradiation technique must take into account the incidence of side effects related to radiation. In this context, the definition of the target volumes as well as the verification and monitoring of the delivered processing are essential. International recommendations for treatment fields are based on the "involved node radiotherapy" concept. The best irradiation technique to use remains to be ...
Source: Cancer Radiotherapie - July 31, 2018 Category: Cancer & Oncology Authors: Boros A, Ribrag V, Deutsch É, Chargari C, Izar F Tags: Cancer Radiother Source Type: research

[Technical aspects and indications of extracranial stereotactic radiotherapy].
va YM Abstract Extracranial stereotactic radiotherapy has developed considerably in recent years and is now an important part of the therapeutic alternatives to be offered to patients with cancer. It offers opportunities that have progressively led physicians to reconsider the therapeutic strategy, for example in the case of local recurrence in irradiated territory or oligometastatic disease. The literature on the subject is rich but, yet, there is no real consensus on therapeutic indications. This is largely due to the lack of prospective, randomized studies that have evaluated this technique with sufficient reco...
Source: Cancer Radiotherapie - July 28, 2018 Category: Cancer & Oncology Authors: Bazire L, Darmon I, Calugaru V, Costa É, Dumas JL, Kirova YM Tags: Cancer Radiother Source Type: research

Three-year results after radiotherapy for locally advanced sinonasal adenoid cystic carcinoma, using highly conformational radiotherapy techniques proton therapy and/or Tomotherapy.
CONCLUSION: Combining high-dose proton therapy and Tomotherapy is effective and has moderate toxicity in the treatment of T4 sinonasal adenoid cystic carcinoma involving skull base. PMID: 30064829 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 28, 2018 Category: Cancer & Oncology Authors: Dautruche A, Bolle S, Feuvret L, Le Tourneau C, Jouffroy T, Goudjil F, Zefkili S, Nauraye C, Rodriguez J, Herman P, Calugaru V Tags: Cancer Radiother Source Type: research

Multimodality imaging using PET/CT (18F)-fluorodeoxyglucose for radiotherapy field delineation of localized Hodgkin lymphoma.
We report here the usual procedures of PET/CT acquisition in the radiotherapy environment and propose a more sophisticated description of the different lymph nodes for a more efficient nuclear medicine report to the radiation oncologist. PMID: 30055933 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 25, 2018 Category: Cancer & Oncology Authors: Édeline V, Remouchamps V, Isnardi V, Vander Borght T Tags: Cancer Radiother Source Type: research

[Small cell neuroendocrine carcinoma of the bladder: Report of five cases and a review of the literature].
We report our experience in the management of these tumours with literature review. PMID: 30049597 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 23, 2018 Category: Cancer & Oncology Authors: Safini F, Jouhadi H, Marnissi F, Bouchbika Z, Benchakroun N, Tawfiq N, Sahraoui S, Benider A Tags: Cancer Radiother Source Type: research

Role of FDG PET-CT in the treatment management of Hodgkin lymphoma.
ine V Abstract Fluorodeoxyglucose (FDG) positons emission tomography (PET)-computed tomography (CT) is used in many ways at baseline and during the treatment of patients with Hodgkin lymphoma. Many properties of the technique are used in the different steps of patient's management. Initial staging with PET-CT is more accurate than conventional imaging and PET-CT also became the gold standard imaging at the end of treatment with a negative PET-CT mandatory for reaching a complete remission. Early assessment of response by PET-CT is one of the most powerful prognostic factors for progression-free survival of patient...
Source: Cancer Radiotherapie - July 19, 2018 Category: Cancer & Oncology Authors: Berriolo-Riedinger A, Becker S, Casasnovas O, Vander Borght T, Édeline V Tags: Cancer Radiother Source Type: research

[Bone metastases radiotherapy: Multi-approaches literature review].
A, Noël G Abstract External beam radiation therapy is an efficient treatment, which relieves pain associated with bone metastases, and is prescribed in worldwide. Although bone metastases palliative irradiation recommendations exist, international clinical practices remain variable. The purpose of this article is to show the clinical practices evolution though clinical trials, cost studies and techniques' progression. PMID: 30001971 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - July 9, 2018 Category: Cancer & Oncology Authors: Le Fèvre C, Antoni D, Thiéry A, Noël G Tags: Cancer Radiother Source Type: research

Salvage brachytherapy as a modern reirradiation technique for local cancer failure: The Phoenix is reborn from its ashes.
ute;hange G Abstract The treatment of local recurrence of a previously irradiated cancer or a second cancer arising in-field remains challenging. Ultimately, the objective of salvage therapy is to control disease while ensuring minimal collateral damage, thereby optimizing both cancer and toxicity outcomes. Reirradiation has historically been associated with unacceptable toxicity and a limited benefit. Brachytherapy offers the best dose distribution and a high radiation dose to the target volume while better protecting surrounding previously irradiated healthy tissues. The management of local cancer recurrence in ...
Source: Cancer Radiotherapie - May 30, 2018 Category: Cancer & Oncology Authors: Quivrin M, Peignaux-Casasnovas K, Martin É, Rouffiac M, Thibouw D, Chevalier C, Vulquin N, Aubignac L, Truc G, Créhange G Tags: Cancer Radiother Source Type: research

Implementation of failure mode and effective analysis for high dose rate brachytherapy at Tata Memorial Hospital, Mumbai, India.
CONCLUSIONS: Failure mode and effective analysis is a useful tool that uses a systematic approach for quality management of a specific process. PMID: 29859762 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 30, 2018 Category: Cancer & Oncology Authors: Swamidas J, Khanna N, Mahantshetty U, Somesan V, Deshpande DD, Shrivastava SK Tags: Cancer Radiother Source Type: research

[Prostate brachytherapy: New techniques, new indications].
Abstract Prostate brachytherapy has been for a long time one of the standard treatments for low risk prostate cancer, with high rates of biochemical control and low levels of urinary and sexual late toxicity compared to other available techniques, namely external beam radiotherapy and radical prostatectomy. The aim of this article is to review the recent innovations of prostate brachytherapy, which suggest a bright future for the technique. We will discuss the extension of indications of permanent implant brachytherapy to favorable intermediate-risk patients, the use of novel isotopes such as Palladium 103 and Ces...
Source: Cancer Radiotherapie - May 29, 2018 Category: Cancer & Oncology Authors: Blanchard P, Graff-Cailleaud P, Bossi A Tags: Cancer Radiother Source Type: research

Endoluminal brachytherapy: Bronchus and oesophagus.
;ro L Abstract Endobronchial brachytherapy could be proposed in case of endoluminal tumours either as a palliative or a curative treatment. As a curative treatment, endobronchial brachytherapy could obtain a high local control rate in case of limited disease. In palliative setting, endobronchial brachytherapy improved thoracic symptoms in more than 80% of cases, but it is less efficient than external beam radiation therapy for palliation. It could be also proposed to maintain the airway open after laser therapy. Oesophageal brachytherapy is a valuable option as a palliative treatment, underused at this time. It ca...
Source: Cancer Radiotherapie - May 29, 2018 Category: Cancer & Oncology Authors: Hennequin C, Guillerm S, Wong S, Quéro L Tags: Cancer Radiother Source Type: research

Place of modern imaging in brachytherapy planning.
Abstract Imaging has probably been the most important driving force for the development of brachytherapy treatments the last 20 years. Due to implementation of three-dimensional imaging, brachytherapy is nowadays a highly accurate and reliable treatment option for many cancer patients. To be able to optimize the dose distribution in brachytherapy the anatomy and the applicator(s) or sources should be correctly localised in the images. For computed tomography (CT) the later criteria is easily fulfilled for most brachytherapy sites. However, for many sites, like cervix and prostate, CT is not optimal for delineation...
Source: Cancer Radiotherapie - May 29, 2018 Category: Cancer & Oncology Authors: Hellebust TP Tags: Cancer Radiother Source Type: research

Radiobiology of brachytherapy: The historical view based on linear quadratic model and perspectives for optimization.
acute;der C Abstract Most preclinical studies examining the radiobiology of brachytherapy have focused on dose rate effects. Scarcer data are available on other major parameters of therapeutic index, such as cell cycle distribution, repopulation or reoxygenation. The linear quadratic model describes the effect of radiotherapy in terms of normal tissue or tumour response. It allows some comparisons between various irradiation schemes. This model should be applied cautiously for brachytherapy, because it relies on cell death analysis only, and therefore partially reflects the biological effects of an irradiation. Mo...
Source: Cancer Radiotherapie - May 29, 2018 Category: Cancer & Oncology Authors: Chargari C, Van Limbergen E, Mahantshetty U, Deutsch É, Haie-Méder C Tags: Cancer Radiother Source Type: research

[Brachytherapy for head and neck cancers].
ard S Abstract The main indications of the brachytherapy of head and neck cancers are the limited tumours of the lip, the nose, the oral cavity and the oropharynx. Nasopharynx tumours are nowadays treated by intensity-modulated radiotherapy. This technique can be exclusive, associated with external radiotherapy or postoperative. It can also be a salvage treatment for the second primaries in previously irradiated areas. If the low dose rate brachytherapy rules remain the reference, the pulse dose rate technique allows the prescription of the dose rate and the optimisation of the dose distribution. Results of high d...
Source: Cancer Radiotherapie - May 29, 2018 Category: Cancer & Oncology Authors: Peiffert D, Coche-Dequéant B, Lapeyre M, Renard S Tags: Cancer Radiother Source Type: research

Total neoadjuvant therapy for rectal cancer.
Abstract While outcomes for patients with locally advanced disease have improved considerably with combined modality therapy, there is now an emphasis on developing risk-adapted treatment strategies. Moreover, the primary cause of death from locally advanced rectal cancer is related to distant progression, which now exceeds the rate of local failure. Thus, the necessity to optimally address micrometastatic disease has led to increasing interest in delivering chemotherapy in the neoadjuvant setting rather than in the postoperative setting. This review critically appraises the emerging literature on the options for ...
Source: Cancer Radiotherapie - May 25, 2018 Category: Cancer & Oncology Authors: Goodman KA Tags: Cancer Radiother Source Type: research

Multicatheter interstitial brachytherapy for breast cancer.
;v JM Abstract Brachytherapy remains the best irradiation technique to deliver a high dose in a small volume. Breast brachytherapy is part of the arsenal of therapy in the management of breast cancer. In this article, we present the technical data related to multicatheter interstitial brachytherapy to the breast proceeding, from the implantation of the vectors to the treatment itself. The indications for brachytherapy in breast cancer are boost after whole breast irradiation, accelerated partial breast irradiation or selected patients with second ipsilateral breast tumor event. The results in terms of efficacy and...
Source: Cancer Radiotherapie - May 23, 2018 Category: Cancer & Oncology Authors: Sumodhee S, Strnad V, Hannoun-Lév JM Tags: Cancer Radiother Source Type: research

[New calculation algorithms in brachytherapy for iridium 192 treatments].
Abstract Since 1995, the brachytherapy dosimetry protocols follow the methodology recommended by the Task Group 43. This methodology, which has the advantage of being fast, is based on several approximations that are not always valid in clinical conditions. Model-based dose calculation algorithms have recently emerged in treatment planning stations and are considered as a major evolution by allowing for consideration of the patient's finite dimensions, tissue heterogeneities and the presence of high atomic number materials in applicators. In 2012, a report from the American Association of Physicists in Medicine Ra...
Source: Cancer Radiotherapie - May 18, 2018 Category: Cancer & Oncology Authors: Robert C, Dumas I, Martinetti F, Chargari C, Haie-Meder C, Lefkopoulos D Tags: Cancer Radiother Source Type: research

[Why is brachytherapy still essential in 2017?]
ari C Abstract These recent years, brachytherapy has benefited from imaging modalities advances. A more systematic use of tomodensitometric, ultrasonographic and MRI images during brachytherapy procedures has allowed an improvement in target and organs at risk assessment as well as their relationship with the applicators. New concepts integrating tumor regression during treatment have been defined and have been clinically validated. New applicators have been developed and are commercially available. Optimization processes have been developed, integrating hypofractionation modalities leading to tumor control improv...
Source: Cancer Radiotherapie - May 16, 2018 Category: Cancer & Oncology Authors: Haie-Méder C, Maroun P, Fumagalli I, Lazarescu I, Dumas I, Martinetti F, Chargari C Tags: Cancer Radiother Source Type: research

Renaud Mazeron: A great scientist and teacher who contributed to GEC ESTRO for a decade. Tribute to Dr. Renaud Mazeron (1977-2016).
degaard J PMID: 29778451 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 16, 2018 Category: Cancer & Oncology Authors: Nout R, Kirisits C, Tanderup K, Pötter R, Haie-Méder C, Pieters B, Lindegaard J Tags: Cancer Radiother Source Type: research

Pharmacological modulation of radiation-induced oral mucosal complications.
The objective of this article was to review the latest updates in the management of radiation-induced mucositis, with a focus on pharmaceutical strategies for the prevention or treatment of mucositis. Although numerous studies analysing the prevention and management of oral radiation-induced mucositis have been conducted, there are still few reliable data to guide daily clinical practice. Furthermore, most of the tested drugs have shown no (anti-inflammatory cytokine, growth factors) or limited (palifermin) effect. Therapies for acute oral mucositis are predominantly focused on improving oral hygiene and providing symptoms...
Source: Cancer Radiotherapie - May 15, 2018 Category: Cancer & Oncology Authors: Bockel S, Vallard A, Lévy A, François S, Bourdis M, Le Gallic C, Riccobono D, Annede P, Drouet M, Tao Y, Blanchard P, Deutsch É, Magné N, Chargari C Tags: Cancer Radiother Source Type: research

3D brachytherapy for cervical cancer: New optimization ways.
ari C Abstract Brachytherapy has known major improvements in recent decades. It represents an essential component of local treatment of cervix cancers. One major breakthrough was the advent of 3D imaging for image-guided brachytherapy. Doses could be prescribed to volumes. This allows better delineation and coverage of target volumes, as well as organs at risk (bladder, rectum, sigmoid) protection. Local recurrences have been consequently reduced and survival has been improved. In addition, improvement and development of new applicators have facilitated the delivery of interstitial treatments. Afterloading applica...
Source: Cancer Radiotherapie - May 15, 2018 Category: Cancer & Oncology Authors: Fumagalli I, Haie-Méder C, Chargari C Tags: Cancer Radiother Source Type: research

[Brachytherapy: The most ancient of modern radiation techniques].
der C PMID: 29773472 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 14, 2018 Category: Cancer & Oncology Authors: Chargari C, Maingon P, Mornex F, Haie-Méder C Tags: Cancer Radiother Source Type: research

[Base of the skull meningioma: Efficacy, clinical tolerance and radiological evaluation after radiotherapy].
l G Abstract Skull base meningioma leads to functional disturbances, which can significantly alter the quality of life. The optimal management of these lesions, whose goals are neurological preservation and tumour local control, is not yet clearly established. It is widely recognized that the goal of a radical excision should be abandoned despite the advances in the field of microsurgery of skull base lesions. Although less morbid, partial tumour excision would be associated with increased risk of local tumour recurrence. Although discussed both exclusive and adjuvant have proven to be highly successful in terms o...
Source: Cancer Radiotherapie - May 14, 2018 Category: Cancer & Oncology Authors: Brahimi Y, Antoni D, Srour R, Proust F, Cebula H, Labani A, Noël G Tags: Cancer Radiother Source Type: research

[Advances in the management of cervical lymphadenopathies of unknown primary with intensity modulated radiotherapy: Doses and target volumes].
iat J Abstract The definition of nodal and/or mucosal target volumes for radiation therapy for lymphadenopathies of unknown primary is controversial. Target volumes may include all nodal areas bilaterraly and be pan-mucosal or unilateral, selective, including the sole oropharyngeal mucosa. This review presents current recommendations in light of changes in the TNM classification, Human papillomavirus status and therapeutic advances. We conducted a systematic review of the literature with the following keywords: lymphadenopathy; head and neck; unknown primary and radiation therapy. There are no direct comparative s...
Source: Cancer Radiotherapie - May 3, 2018 Category: Cancer & Oncology Authors: Troussier I, Klausner G, Blais E, Giraud P, Lahmi L, Pflumio C, Faivre JC, Geoffrois L, Babin E, Morinière S, Maingon P, Thariat J Tags: Cancer Radiother Source Type: research

Adaptive radiotherapy for head and neck cancers: Fact or fallacy to improve therapeutic ratio?
Abstract Modern standards of precision radiotherapy, primarily driven by the technological advances of intensity modulation and image guidance, have led to increased versatility in radiotherapy planning and delivery. The ability to shape doses around critical normal organs, while simultaneously "painting" boost doses to the tumor have translated to substantial therapeutic gains in head and neck cancer patients. Recently, dose adaptation (or adaptive radiotherapy) has been proposed as a novel concept to enhance the therapeutic ratio of head and neck radiotherapy, facilitated in part by the onset of molecu...
Source: Cancer Radiotherapie - April 23, 2018 Category: Cancer & Oncology Authors: Li YQ, Tan JSH, Wee JTS, Chua MLK Tags: Cancer Radiother Source Type: research