Survival comparision of three-dimensional radiotherapy alone with concurrent chemoradiotherapy for non-surgical esophageal carcinoma.
CONCLUSION: For non-surgical esophageal carcinoma patients, 3DRT combined with CCRT was effective in prolonging both OS and PFS. PMID: 32001131 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 26, 2020 Category: Cancer & Oncology Authors: Tan L, Xiao Z, Zhang H, Chen D, Feng Q, Zhou Z, Lv J, Liang J, Yin W Tags: Cancer Radiother Source Type: research

Dose distribution of the brain tissue associated with cognitive functions in high-grade glioma patients.
Abstract PURPOSE: The purpose of this prospective dosimetric study was to assess the dose distribution regarding the brain areas implied in cognitive functions using two approaches: volumetric modulated arc therapy (VMAT) and helical tomotherapy (HT). PATIENTS AND METHODS: Thirty-seven patients were treated using a dual-arc VMAT approach for supratentorial glioblastoma between 2016 and 2018. The total dose of 60Gy in 30 daily fractions was administered to the planning target volume (PTV). The brain structures that play an important role in cognitive physiology, such as the hippocampi, corpus callosum, cerebel...
Source: Cancer Radiotherapie - January 24, 2020 Category: Cancer & Oncology Authors: Jacob J, Clausse E, Benadjaoud MA, Jenny C, Ribeiro M, Feuvret L, Mazeron JJ, Antoni D, Bernier MO, Hoang-Xuan K, Psimaras D, Carpentier A, Ricard D, Maingon P Tags: Cancer Radiother Source Type: research

[Salivary ductal carcinoma of the parotid: A rare and agressive entity].
We report a rare case of salivary duct carcinoma and we study its clinical and evolutionary features. A 64-year-old patient was referred for right peripheral facial paralysis. MRI showed suspected formation of the right parotid gland. Treatment included total parotidectomy and ipsilateral neck lymph node dissection. The histology concluded to a ductal carcinoma of the parotid with lymph node metastasis. Radiation therapy has been indicated. Salivary duct carcinoma of the parotid gland is a highly aggressive and uncommon tumor. Treatment of localized forms is based on surgery and radiotherapy. PMID: 31992517 [PubMed - ...
Source: Cancer Radiotherapie - January 24, 2020 Category: Cancer & Oncology Authors: Bouatay R, Harrathi K, Chefai J, Abdejlil N, Koubaa J Tags: Cancer Radiother Source Type: research

[What is the impact of IMRT of nasopharyngeal carcinomas on glandular structures?]
CONCLUSION: The modifications observed for glandular structures during NPC IMRT can explain the different toxicities caused by radiation. It seems also that a careful adaptation of the treatment plan should be considered during therapy. PMID: 31992518 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 24, 2020 Category: Cancer & Oncology Authors: Mnejja W, Daoud H, Fourati N, Sahnoun T, Siala W, Farhat L, Daoud J Tags: Cancer Radiother Source Type: research

[Predictors of asthenia in breast and prostate cancer patients undergoing curative radiotherapy].
CONCLUSION: Radiotherapy-related fatigue is a common side effect. This study showed that most of the factors related to patients or disease that are commonly used to explain fatigue during curative treatments, seem finally to be not correlated with asthenia. PMID: 31983629 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - January 22, 2020 Category: Cancer & Oncology Authors: Guillaume E, Daguenet E, Lahmamssi C, Ben Mrad M, Jmour O, Langrand-Escure J, Rehailia-Blanchard A, Vial N, Pigné G, Bard-Reboul S, Maison M, Tinquaut F, Vallard A, Magné N Tags: Cancer Radiother Source Type: research

[A survey of Belgian practice for non-malignant diseases].
Abstract Two prior surveys were carried out in 1995 and 1999 to evaluate the use of radiotherapy in the treatment of non-malignant disease. In 2016, the same questionnaire was used and sent to the 24 centers of the country: 22 responded. A major decrease was observed in the number of patients treated: 360 in 2016 in contrast to 954 in 1999 and 1113 in 1995. The most frequent indications remain the prevention of heterotopic bone formation, keloids or gynecomastia. A new indication was observed: trigeminal nevralgia treated with radiosurgery. Two frequent indications in the past disappeared: the prevention of corona...
Source: Cancer Radiotherapie - January 20, 2020 Category: Cancer & Oncology Authors: Van Houtte P, Remouchamps V, Lievens Y, Belgian College for Physicians in Radiation Oncology Tags: Cancer Radiother Source Type: research

Two cases of Hemosuccus pancreaticus after stereotactic radiotherapy to the pancreas: A case study.
We present 2 cases of patients who underwent stereotactic radiotherapy for pancreatic lesions who manifested signs of HP after treatment. Two male patients were diagnosed with an inoperable locally advanced pancreatic cancer and underwent 8 cycles of chemotherapy followed by stereotactic radiotherapy to the pancreatic lesion delivering 40Gy in 8 fractions. The first patient complained of melena and had a necrotic tumoural mass with a new aneurysmal bulge 3 months after the SBRT. A stent was placed in the aneurysmal lesion, however, a few days later, the bleeding occurred again and the patient died. The ...
Source: Cancer Radiotherapie - January 20, 2020 Category: Cancer & Oncology Authors: Pezulla D, Loi M, Suker M, van Eijck C, Nuyttens J Tags: Cancer Radiother Source Type: research

Hypofractionated stereotactic radiotherapy for challenging brain metastases using 36  Gy in six fractions.
CONCLUSION: The 6×6Gy hypofractionated stereotactic radiotherapy scheme seems to yield quite good results in patients with haemorrhagic brain metastases, which must be confirmed in a prospective way. PMID: 31677901 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 29, 2019 Category: Cancer & Oncology Authors: Dumont Lecomte D, Lequesne J, Geffrelot J, Lesueur P, Barraux V, Loiseau C, Lacroix J, Leconte A, Émery É, Thariat J, Stefan D Tags: Cancer Radiother Source Type: research

[Solitary bone plasmocytoma: Experience from the radiotherapy department at Mohammed-V military teaching hospital in Rabat (Morocco)].
CONCLUSION: Radiation therapy is the standard treatment for solitary bone plasmocytoma. It ensures good local control in 90% of cases. The prognosis is affected by progression to multiple myeloma, which justifies rigorous monitoring after treatment and suggests a reflection on the exact place of chemotherapy. PMID: 31677902 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 29, 2019 Category: Cancer & Oncology Authors: Hadadi K, Hommadi M, Belemlih M, Zaghba N, Maghous A, Marnouch EA, Saghir KA, Elmarjany M, Sifat H, Oukabli M, Mansouri H Tags: Cancer Radiother Source Type: research

[Basis and perspectives of artificial intelligence in radiation therapy].
Abstract Artificial intelligence is a highly polysemic term. In computer science, with the objective of being able to solve totally new problems in new contexts, artificial intelligence includes connectionism (neural networks) for learning and logics for reasoning. Artificial intelligence algorithms mimic tasks normally requiring human intelligence, like deduction, induction, and abduction. All apply to radiation oncology. Combined with radiomics, neural networks have obtained good results in image classification, natural language processing, phenotyping based on electronic health records, and adaptive radiation t...
Source: Cancer Radiotherapie - October 19, 2019 Category: Cancer & Oncology Authors: Burgun A Tags: Cancer Radiother Source Type: research

Hypofractionated radiotherapy for non-metastatic bone and soft tissue sarcomas.
CONCLUSION: Hypofractionated radiotherapy as the primary treatment or for reirradiation has been shown to be safe in the treatment of bone and soft tissue sarcomas. It can provide relatively good local control and survival rates. PMID: 31640927 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 18, 2019 Category: Cancer & Oncology Authors: Yuce Sari S, Cengiz M, Dauletkazin A, Yazici G, Gultekin M, Hurmuz P, Yildiz F, Zorlu F, Gurkaynak M, Akyol F, Ozyigit G Tags: Cancer Radiother Source Type: research

[Inter- and intrafraction imaging during stereotactic body radiation therapy: Which solutions for which tumours?]
Abstract Due to high dose gradients, stereotactic body radiation therapy requires high precision in the location of the tumour. Uncertainties in the positioning can introduce serious damage on organs at risk and consequently can reduce tumour local control. A better tumour location can be achieved by controlling its position with an efficient inter and intrafraction imaging procedure. The various imaging techniques available on treatment systems are presented and performances are discussed. Finally, propositions are given in terms of imaging system according to the location treated by stereotactic body radiation t...
Source: Cancer Radiotherapie - October 11, 2019 Category: Cancer & Oncology Authors: Gensanne D, Hadj Henni A, Lauzin Y, Clarisse P, Thureau S Tags: Cancer Radiother Source Type: research

DNA repair inhibitors to enhance radiotherapy: Progresses and limitations.
Abstract Radiotherapy is one of the most common form of treatment in oncology care. Indeed, radiotherapy proved to be very effective in treating a wide range of malignancies. Nevertheless, certain tumours are intrinsically radioresistant or may evolve to become radioresistant. Resistance to radiotherapy is often associated with dysregulated DNA damage response and repair. Recently, a number of strategies have been developed to improve radiotherapy efficacy by targeting the DNA damage response and repair pathways. Ongoing clinical trials showed the potential of some of these approaches in enhancing radiotherapy, bu...
Source: Cancer Radiotherapie - October 11, 2019 Category: Cancer & Oncology Authors: Ferreira S, Dutreix M Tags: Cancer Radiother Source Type: research

Hypofractionated radiation therapy for invasive breast cancer: From moderate to extreme protocols.
We report here oncological outcomes and toxicity of hypofractionated breast irradiation. After defining the frame of moderate and extreme hypofractionated breast irradiations based on overall treatment time, patient selection criteria were listed. According to their levels of proof, the results of moderate and extreme hypofractionated breast irradiation were analysed. Overall treatment time for moderate hypofractionated breast irradiation ranged from 3 to 4 weeks, while for extreme hypofractionated breast irradiation, it was less than 1 week. For moderate hypofractionated breast irradiation, whole breast irradiation w...
Source: Cancer Radiotherapie - October 10, 2019 Category: Cancer & Oncology Authors: Rivera S, Hannoun-Lévi JM Tags: Cancer Radiother Source Type: research

Illustration of a fatal radiation-induced lung aneurysm: Is central lung stereotactic radiotherapy to be banned?
We report the case of a 59-year-old woman with previous history of head and neck squamous cell carcinoma who was treated by lung stereotactic body irradiation for an inoperable lymph node in station 10R. One year after, a fibroscopy showed a necrosis of the right main bronchus mucosae and the CT showed a radio-induced aneurysm protruding into the right inferior lobular bronchus. The patient eventually died a few hours later with a massive haemoptysis. This case highlights the potential toxicity of central lung stereotactic body radiation therapy and raises the question of its legitimacy. PMID: 31611052 [PubMed - as su...
Source: Cancer Radiotherapie - October 10, 2019 Category: Cancer & Oncology Authors: Ledoux B, Dupont M, Duplaquet F, Pirard L, Ocak S, Wanet M, Remouchamps V Tags: Cancer Radiother Source Type: research

[Prophylactic nodal radiotherapy for breast cancer].
era S Abstract Adjuvant radiotherapy is a key treatment in early-stage breast cancer. The meta-analysis by the Early Breast Cancer Trialist's Collaborative Group (EBCTCG) has demonstrated a decreased risk of locoregional relapse and death after whole-breast radiotherapy. Prophylactic lymph nodes irradiation in breast cancer has also proven to be beneficial in several therapeutic trials. At a time when three-dimensional conformal radiotherapy has become the standard procedure and with the development of intensity-modulated radiation therapy, defining nodal volumes is essential and practices should be harmonized to ...
Source: Cancer Radiotherapie - October 4, 2019 Category: Cancer & Oncology Authors: Rogé M, Thureau S, Dampierre J, Dubray B, Rivera S Tags: Cancer Radiother Source Type: research

[Radiotherapy of oligometastases: Sequences and interactions with systemic therapies, example of kidney cancer].
This article is a review of the literature that aims to clarify the place of systemic and locoregional treatments, with a focus on radiotherapy and surgery in the management of patients with oligometastatic kidney cancer. We have selected articles of interest published in Medline indexed journals. We have also analysed the related guidelines: National Comprehensive Cancer Network (NCCN) 2019, European Association of Urology (EAU) 2019, European Society of Medical Oncology (ESMO) 2019, Association française d'urologie (Afu) 2018 as well as some abstracts of international congresses. The main treatments evaluated were...
Source: Cancer Radiotherapie - October 3, 2019 Category: Cancer & Oncology Authors: Wespiser M, Goujon M, Nguyen Tan Hon T, Maurina T, Kleinclauss F, Créhange G, Thiery-Vuillemin A Tags: Cancer Radiother Source Type: research

[Use of nanoparticles as radiosensitizing agents in radiotherapy: State of play].
Abstract Nanomedicine has undergone significant development since the 2000s and it is only very recently that two metallic nanoparticles have emerged in clinical trials. The mechanism of these radiosensitizing agents is based on the presence of atoms with a high atomic number (Z) allowing a higher dose deposition into the tumor during irradiation. The first nanoparticle used in humans is NBTXR3, composed of hafnium (Z=79), with intratumor injection for the treatment of sarcoma. Another gadolinium-based nanoparticle (Z=64), AGuIX, has been used for intravenous injection in the treatment of brain metastases. The pre...
Source: Cancer Radiotherapie - September 16, 2019 Category: Cancer & Oncology Authors: Verry C, Porcel E, Chargari C, Rodriguez-Lafrasse C, Balosso J Tags: Cancer Radiother Source Type: research

[Lung cancer and elective nodal irradiation: A solved issue?]
ute;choux C Abstract Lung cancer treatment is a heavy workload for radiation oncologist and that field showed many evolutions over the last two decades. The issue about target volume was raised when treatment delivery became more precise with the development of three-dimensional conformal radiotherapy. Initially based upon surgical series, numerous retrospective and prospective studies aimed to evaluate the risk of elective nodal failure of involved-field radiotherapy compared to standard large field elective nodal irradiation. In every setting, locally advanced non-small cell lung cancer, localized non-small cell...
Source: Cancer Radiotherapie - September 5, 2019 Category: Cancer & Oncology Authors: Laurans M, Botticella A, Moukasse Y, Lévy A, Le Péchoux C Tags: Cancer Radiother Source Type: research

[Treatment of primary disease (breast, non-small cell lung and prostate cancers) with irradiation in case of de novo metastatic cancer].
This article reviews the indication of radiotherapy as a local treatment for primary cancer in a de novo metastatic diagnosed disease in the case of breast cancer, non-small cell lung cancer and prostate cancer. PMID: 31501025 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 5, 2019 Category: Cancer & Oncology Authors: Latorzeff I, Bourgier C, Pinel B, Hennequin C, Jimenez G, Chapet O, Zasadny X Tags: Cancer Radiother Source Type: research

[Treatment of oligometastatic or oligoprogression cancer].
Abstract We propose in this short review to report the impact of stereotactic body radiation therapy (SBRT) in oligometastatic or oligoprogressive cancer patients in terms of metastatic progression-free and global survival, and to identify the place of SBRT in patient's pathway. PMID: 31495737 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - September 4, 2019 Category: Cancer & Oncology Authors: Bourgier C, Latorzeff I, Fenoglietto P, Boisselier P, Charissoux M, Llacer C, Lemanski C, Riou O, Farcy-Jacquet MP, Azria D Tags: Cancer Radiother Source Type: research

Spatial fractionation of the dose in proton therapy: Proton minibeam radiation therapy.
Abstract In radiation therapy, a renewed interest is emerging for the study of spatially fractionated irradiation. In this article, a few applications using spatial fractionation of the dose will be discussed with a focus on proton minibeam radiation therapy. Examples of calculated dose (1D profiles and 2D dose distributions) and biological evidence obtained so far will be presented for various spatially fractionated techniques GRID, micro- and minibeam radiation therapy. Recent results demonstrating that proton minibeam radiation therapy leads to an increase in normal tissues sparing will be discussed, which open...
Source: Cancer Radiotherapie - September 3, 2019 Category: Cancer & Oncology Authors: De Marzi L, Nauraye C, Lansonneur P, Pouzoulet F, Patriarca A, Schneider T, Guardiola C, Mammar H, Dendale R, Prezado Y Tags: Cancer Radiother Source Type: research

Cancer of the oesophagus and lymph nodes management in the neoadjuvant or definitive radiochemotherapy setting.
nat S Abstract Despite representing a 1% of diagnosed cancer cases in the USA and up to 5% in eastern Asia and Africa, oesophageal cancer still holds numerous questions concerning the best therapeutic management. For squamous cell carcinoma, while radiochemotherapy has proven itself to be the gold standard as part of the trimodality or alone as a definitive treatment, radiotherapy modalities are still debated especially regarding lymph node irradiation. Involved nodes irradiation was developed with the aim of maintaining clinical outcomes and enhancing quality of life but lacks grade 1 evidence. In this article, w...
Source: Cancer Radiotherapie - September 2, 2019 Category: Cancer & Oncology Authors: Bourbonné V, Pradier O, Schick U, Servagi-Vernat S Tags: Cancer Radiother Source Type: research

[Proton therapy in France in 2019].
é MA Abstract Among over 100 proton therapy centres worldwide in operation or under construction, French proton therapy is coming to full maturity with the recent opening of the Nice (1991, upgrade in 2016) and Caen (2018) facilities next to the Orsay (1991, upgrade in 2010) centre. Proton therapy is a national priority for children and young adults in all three centres. The patient-related activity of the three French centres is coordinated via the Protonshare portal to optimise referral by type of indication and available expertise in coordination with the French society of radiation oncology SFRO and Fre...
Source: Cancer Radiotherapie - August 29, 2019 Category: Cancer & Oncology Authors: Dendale R, Thariat J, Doyen J, Balosso J, Stefan D, Bolle S, Feuvret L, Poortmans P, Hannoun-Lévi JM, Bondiau PY, Micaud M, Alapetite C, Calugaru V, Habrand JL, Mahé MA Tags: Cancer Radiother Source Type: research

[Stereotactic radiotherapy of brain metastases in complex situations].
This article aims to put forward the arguments available to date in the literature and those resulting from clinical practice to provide decision support for the radiation oncologists. PMID: 31477442 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 29, 2019 Category: Cancer & Oncology Authors: Noel G, Keller A, Antoni D Tags: Cancer Radiother Source Type: research

Combination of chemotherapy and radiotherapy: A thirty years evolution.
Abstract Chemoradiotherapy is now considered the standard of care for many locally advanced diseases. Cytotoxic drugs have been largely evaluated in this setting, with cisplatin and 5FU the most often used drugs. A large amount of pre-clinical studies has demonstrated the synergy between both modalities. Concomitant administration seems the more beneficial in many diseases. Emergence of new approaches, combining targeted therapies and radiotherapy (RT) is now a reality. The main example is the association of cetuximab and RT in head and neck carcinomas, even if, 14 years after the initial publication, the best way...
Source: Cancer Radiotherapie - August 27, 2019 Category: Cancer & Oncology Authors: Hennequin C, Guillerm S, Quero L Tags: Cancer Radiother Source Type: research

[Overview of adaptive radiotherapy in 2019: From implementation to clinical use].
Abstract Intensity modulated radiotherapy combined with image guided radiotherapy has led to increase the precision of external beam radiotherapy. However, intra or inter-fraction anatomical variations are frequent during the treatment course and can cause under-dosing of the target volume and/or over-dosing of the organs at risk. Several adaptive radiotherapy (ART) strategies can be defined to compensate these anatomical variations. The purpose of this article is to provide an overview of available ART strategies: offline, online, hybrid (library of treatment plans) or in real-time, while considering the arrival ...
Source: Cancer Radiotherapie - August 27, 2019 Category: Cancer & Oncology Authors: Badey A, Barateau A, Delaby N, Fau P, Garcia R, De Crevoisier R, Lisbona A Tags: Cancer Radiother Source Type: research

Cancer du canal anal  : personnalisation de la dose, du volume et du fractionnement.
Cancer du canal anal : personnalisation de la dose, du volume et du fractionnement. Cancer Radiother. 2019 Aug 27;: Authors: Peiffert D Abstract The conservative treatment of squamous cell carcinoma of anal canal by irradiation is recommended as first indication. Despite its rarity, significant improvements were obtained by retrospective or prospective clinical studies these 20 past years, evaluating concomitant chemotherapy and IMRT. Nevertheless, the individualisation of the treatment, over dose distribution, has poor data available. Fractionation remains classic (1.8-2.0Gy/Fr), but the optimal...
Source: Cancer Radiotherapie - August 26, 2019 Category: Cancer & Oncology Authors: Peiffert D Tags: Cancer Radiother Source Type: research

[Stereotactic body radiotherapy of oligometastases: Main pending trials and to come in France].
Abstract Stereotactic radiotherapy of oligometastases, mono- or hypofractionated, represents a fundamental change in the practice of the specialty as it was developed for a century. Despite the great heterogeneity of sites, techniques, and doses, most studies found a high local control rate, around 70 to 90% at 2 years, and reduced toxicity, around 5% of grade 3 at 2 years. Four main phase II and III trials are underway in France. Future research concerns the association of stereotactic radiotherapy with immunotherapy or different conventional chemotherapy protocols, the identification of the best clinical present...
Source: Cancer Radiotherapie - August 26, 2019 Category: Cancer & Oncology Authors: Giraud P, Tournat H, Kreps S, Bibault JE, Dautruche A, Fabiano E, Feutren T, Durdux C Tags: Cancer Radiother Source Type: research

[Stereotactic pulmonary radiotherapy: Which machine?]
Abstract Stereotactic radiotherapy represents a fundamental change in the practice of radiotherapy of lung cancers. Despite the great heterogeneity of sites, techniques, and doses, most studies found a high local control rate, around 70 to 90% at 2 years, and reduced toxicity, around 5% of grade 3 at 2 years. Stereotactic radiotherapy can be realized either by a dedicated accelerator (CyberKnife®) or by a conventional accelerator associated with specific systems. The two modalities deliver a very precise irradiation whose very good results published to date are similar. Some technical characteristics specific ...
Source: Cancer Radiotherapie - August 26, 2019 Category: Cancer & Oncology Authors: Giraud P, Kreps S, Tournat H, Bibault JE, Fabiano E, Feutren T, Dautruche A, Durdux C Tags: Cancer Radiother Source Type: research

[Moderate or extreme hypofractionation  and localized prostate cancer: The times are changing].
[Moderate or extreme hypofractionation and localized prostate cancer: The times are changing]. Cancer Radiother. 2019 Aug 27;: Authors: Line Krhili S, Créhange G, Albert-Dufrois H, Guimas V, Minsat M, Supiot S Abstract There are many treatment options for localized prostate cancers, including active surveillance, brachytherapy, external beam radiotherapy, and radical prostatectomy. Quality of life remains a primary objective in the absence of superiority of one strategy over another in terms of specific survival with similar long-term biochemical control rates. Despite a significant decrea...
Source: Cancer Radiotherapie - August 26, 2019 Category: Cancer & Oncology Authors: Line Krhili S, Créhange G, Albert-Dufrois H, Guimas V, Minsat M, Supiot S Tags: Cancer Radiother Source Type: research

[Hybrid radiotherapy machines: Evolution or revolution?]
Abstract The arrival of new hybrid radiotherapy machines with MRI or PET is announced as a milestone in radiotherapy management. Based on recent literature, we will describe the contribution of each of these modalities and the technological challenges that have already been or are still to be addressed. PMID: 31471254 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 26, 2019 Category: Cancer & Oncology Authors: Ferrer L, Josset S, Moignier A, Delpon G Tags: Cancer Radiother Source Type: research

[Stereotactic radiotherapy of stage I non-small cell lung cancer. State of the art in 2019 and recommendations: Stereotaxy as an alternative to surgery?]
Abstract Stereotactic radiotherapy (or Stereotactic body radiotherapy [SBRT]) is a technique currently well established in the therapeutic arsenal for the management of bronchial cancers. It represents the standard treatment for inoperable patients or who refuses surgery. It is well tolerated, especially in elderly and frail patients, and the current issue is to define its indications in operated patients, based on retrospective and randomized trials comparing stereotactic radiotherapy and surgery, with results equivalents. This work analyzes in detail the different aspects of pulmonary stereotactic radiotherapy a...
Source: Cancer Radiotherapie - August 26, 2019 Category: Cancer & Oncology Authors: Kaiss H, Mornex F Tags: Cancer Radiother Source Type: research

[Experience feedback committees (CREX) in French radiotherapy departments in 2019].
Abstract Ten years after the beginning of CREX in radiotherapy departments we wanted to know about users' feeling. We sent a survey to 168 centers in the whole country and a hundred of them answer. The time, top management's involvement and professionals' training seem to be the key success factors. Systemic analysis methods and mainly the Orion© one are not identified as an issue. The main challenge for the next years will be the effectiveness check of actions. PMID: 31471256 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 26, 2019 Category: Cancer & Oncology Authors: Nardin S, Dupont O Tags: Cancer Radiother Source Type: research

[RadioTransNet, the French network for preclinical research in oncological radiotherapy].
Abstract The ambition of the RADIOTRANSNET network, launched by the INCa at the end of 2018, is to create a French research consortium dedicated to preclinical radiotherapy to foster scientific and clinical interactions at the interface of radiotherapy and radiobiology, and to identify research priorities dedicated to innovation in radiotherapy. The activities of the network are organized around four major axes that are target definition, normal tissue, combined treatments and dose modelling. Under the supervision of the Scientific Council, headed by a coordinator designated by the SFRO and a co-coordinator design...
Source: Cancer Radiotherapie - August 23, 2019 Category: Cancer & Oncology Authors: Bayart E, Azria D, Balosso J, Benderitter M, Cohen-Jonathan Moyal E, Delpon G, Deutsch E, Dutreix M, Lacornerie T, Romeo PH, Marchesi V, Maingon P Tags: Cancer Radiother Source Type: research

[Place of radiotherapy and surgery in the treatment of cervical cancer patients].
Abstract The treatment of cervical cancer patients relies on surgery and radiotherapy (according to the stage) and requires a multimodal discussion before any treatment to avoid adding the morbidities of each individual intervention and to optimize functional and oncological outcomes. The places of surgery and radiotherapy have been highlighted in recent international guidelines. For early stage tumors, an exclusive surgery with or without fertility sparing (according to well defined criteria) is the therapeutic standard. For tumors with risk factors (measuring more than 2cm in size and/or presence of lymphovascul...
Source: Cancer Radiotherapie - August 23, 2019 Category: Cancer & Oncology Authors: Annede P, Gouy S, Haie-Meder C, Morice P, Chargari C Tags: Cancer Radiother Source Type: research

[Adaptation of the HACCP method to the prevention of risks in radiotherapy].
Abstract HACCP method is used for quality insurance in the food industry for many years. It was adapted to radiotherapy to evaluate risk in the treatment process. This pragmatic approach led to the clear identification of different hazards along the process. It also allowed implementation of appropriate measures in order to reduce them. PMID: 31455592 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 23, 2019 Category: Cancer & Oncology Authors: Bleichner O, Legrand-Hamon C Tags: Cancer Radiother Source Type: research

[Prophylactic nodal radiotherapy in prostate cancer].
This article reviews the principles of prophylactic ganglion irradiation for prostate cancer and discusses its relevance, current uncertainties, and prospective trials. PMID: 31451356 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 22, 2019 Category: Cancer & Oncology Authors: Bourdais R, Achkar S, Chauffert-Yvart L, Pasquier D, Sargos P, Blanchard P, Latorzeff I Tags: Cancer Radiother Source Type: research

[Predictive assays for responses of tumors and normal tissues in radiation oncology].
Abstract The impact of curative radiotherapy depends mainly on the total dose delivered homogenously in the target volume. Tumor sensitivity to radiotherapy may be particularly inconstant depending on location, histology, somatic genetic parameters and the capacity of the immune system to infiltrate the tumor. In addition, the dose delivered to the surrounding healthy tissues may reduce the therapeutic ratio of many radiation treatments. In a same population treated in one center with the same technique, it appears that individual radiosensitivity clearly exists, namely in terms of late side effects that are in pr...
Source: Cancer Radiotherapie - August 22, 2019 Category: Cancer & Oncology Authors: Riou O, Bourgier C, Brengues M, Bonnefoi N, Michaud HA, Castan F, Gourgou S, Draghici R, Farcy-Jacquet MP, Bons F, Fenoglietto P, Ozsahin M, Azria D Tags: Cancer Radiother Source Type: research

Curieth érapie guidée par imagerie multimodale : l’exemple du cancer du col utérin.
Curiethérapie guidée par imagerie multimodale : l’exemple du cancer du col utérin. Cancer Radiother. 2019 Aug 23;: Authors: Kumar T, Achkar S, Haie-Meder C, Chargari C Abstract Image-guided brachytherapy is crucial in the management of locally advanced cervical cancers and has benefited from advances in imaging over recent decades. The recommendations of the European Brachytherapy - European Society for Radiation Oncology (GEC-ESTRO) have resulted in harmonized practices and improved clinical outcomes in terms of efficacy and toxicity. Post-implant magnetic resonance im...
Source: Cancer Radiotherapie - August 22, 2019 Category: Cancer & Oncology Authors: Kumar T, Achkar S, Haie-Meder C, Chargari C Tags: Cancer Radiother Source Type: research

[Reirradiation for head and neck squamous cell carcinoma: Indications and results].
Abstract Despite progress in the management of head and neck squamous cell carcinoma (HNSCC), a significant proportion of patients previously irradiated for head-and-neck cancer will develop locoregional recurrence or a second primary. Because of the heterogeneity of this population with respect to disease-related factors (localization, volume, recurrence or second primary, time interval from previous irradiation…) and patient-related factors (comorbidities, sequelae of previous irradiation…), the optimal reirradiation treatment remains to be defined. Salvage therapy using reirradiation, despite some...
Source: Cancer Radiotherapie - August 22, 2019 Category: Cancer & Oncology Authors: Biau J, Moreau J, Blanchard P, Thariat J, Miroir J, Lapeyre M Tags: Cancer Radiother Source Type: research

[Stereotactic body radiotherapy. How to better protect normal tissues?]
Abstract The use of stereotactic body radiotherapy (SBRT) has increased rapidly over the past decade. Optimal preservation of normal tissues is a major issue because of their high sensitivity to high doses per session. Extreme hypofractionation can convert random errors into systematic errors. Optimal preservation of organs at risk requires first of all a rigorous implementation of this technique according to published guidelines. The robustness of the imaging modalities used for planning, and training medical and paramedical staff are an integral part of these guidelines too. The choice of SBRT indications, dose ...
Source: Cancer Radiotherapie - August 21, 2019 Category: Cancer & Oncology Authors: Pasquier D, Lacornerie T, Mirabel X, Brassart C, Vanquin L, Lartigau E Tags: Cancer Radiother Source Type: research

[Stereotactic ablative body radiotherapy: Which machine for which therapeutic indication? A focus on prostate cancer].
This article aims at giving an overview of the published trials, and at pointing out the major differences between the machines, from a clinical (efficacy end toxicity), technical and radiobiological point of view. PMID: 31447340 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 21, 2019 Category: Cancer & Oncology Authors: Lapierre A, Horn S, Créhange G, Enachescu C, Latorzeff I, Supiot S, Sargos P, Hennequin C, Chapet O Tags: Cancer Radiother Source Type: research

[Risk analysis of a complex sociotechnical system: Case of radiotherapy].
The objective of this article is to better secure a care process (making practices more reliable, updating prescribed work, defining preventive and corrective measures, continuing reflections) based on an understanding of the complexity of radiotherapy work situations and a change in our way of thinking about risks. PMID: 31447341 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 21, 2019 Category: Cancer & Oncology Authors: Thellier S, Le Tallec P Tags: Cancer Radiother Source Type: research

[Reirradiation of brain metastasis: Review of the last five years].
Abstract No recommandations have been established for reirradiation of brain metastases yet. The purpose of this review is to analyse the data of the five last years about the feasibility, efficacy and tolerance of reirradiation of brain metastases. Reirradiation can be 3D conformal or stereotactic. Whole brain irradiation seems appropriate for multiple brain metastases in order to obtain symptomatic relief, with or without supportive care. Stereotactic reirradiation has shown satisfying results in terms of overall survival, local control, without significant toxicity. Prospective trials are necessary in order to ...
Source: Cancer Radiotherapie - August 21, 2019 Category: Cancer & Oncology Authors: Nguyen MN, Noel G, Antoni D Tags: Cancer Radiother Source Type: research

[Oral cavity and pharyngo-laryngeal squamous cell carcinoma. What lymph node volumes to select for external beam radiation therapy?]
Abstract The selection of target volumes for head and neck cancer radiation therapy, particularly prophylactic volumes that reflect infra-clinic spreads, is a complex process. It is based on the knowledge of the natural history of these tumors and must take into consideration the special challenges due to the diversity and complexity of head and neck anatomy. The dosimetric and ballistic precision provided by modern radiation techniques has required strong strategic deliberation to ensure the relevance and reproducibility of target volumes. Specifically, regarding cervical lymph node volumes, two issues emerged. W...
Source: Cancer Radiotherapie - August 21, 2019 Category: Cancer & Oncology Authors: Sidibe I, Biau J, Graff P Tags: Cancer Radiother Source Type: research

[The radiation oncologist, one of the actors in the patient's path after cancer. Follow up after prostate cancer].
Abstract Prostate cancer is the most common cancer of men over 50 years old. Localized prostatic cancer treatment may be responsible of a decline of patient's quality of life. The main actors of treatment are now focused on minimizing functional consequences of treatments. The radiation oncologist has a central role in patient monitoring. The follow-up is codified by official recommendations of learned societies to enhance the post-cancer period. The main objective of this article is to review the recommendations for clinical and biological follow-up. An inventory of the functional consequences of the various trea...
Source: Cancer Radiotherapie - August 21, 2019 Category: Cancer & Oncology Authors: Brassart C, Basson L, Olivier J, Latorzeff I, De Crevoisier R, Lartigau E, Pasquier D Tags: Cancer Radiother Source Type: research

[Oligometastases and oligoprogressions: Concepts and natural history].
Abstract The oligometastatic paradigm refers to an intermediate biologic state of cancer with restricted metastatic capacity. Its phenotype is characterized by a limited number of metastases and a slow tumor growth. Various clinical and pre-clinical studies associated this state to alterations of the biological mechanisms involved in metastatic diffusion. Eventually, this transitional state leads to a wide metastatic dissemination. However, there is a period during which the patient could benefit from local ablative treatment. Depending on several prognostic factors and the treatment provided, long survival or eve...
Source: Cancer Radiotherapie - August 21, 2019 Category: Cancer & Oncology Authors: Annede P, Chargari C Tags: Cancer Radiother Source Type: research

Do all the linear accelerators comply with the ICRU 91's constraints for stereotactic body radiation therapy treatments?
ire V Abstract Recent technological developments in linear accelerators (linacs) and their imaging systems have made it possible to routinely perform stereotactic radiotherapy (SRT) treatments. To ensure the security and quality of the treatments, national and international recommendations have been written. This review focuses on the recommendations of the report 91 of the International Commission on Radiation Units (ICRU) on stereotactic treatments with small photon beams and proposes to answer the question of the eligibility of the commercially available accelerators for the treatment of extra-cranial SRT (SBRT...
Source: Cancer Radiotherapie - August 21, 2019 Category: Cancer & Oncology Authors: Biston MC, Dupuis P, Gassa F, Grégoire V Tags: Cancer Radiother Source Type: research

Rationale for hypofractionation.
In conclusion, for all diseases where hypofractionation was demonstrated efficient, it must be fully implemented. Invoice procedures must be adapted to maintain a sufficient level of reimbursement of radiotherapy centers. PMID: 31444076 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 19, 2019 Category: Cancer & Oncology Authors: Hennequin C, Guillerm S, Quero L Tags: Cancer Radiother Source Type: research