Predictive factors assessment of pathological response to neoadjuvant radiotherapy of soft tissue sarcomas
CONCLUSIONS: Neoadjuvant radiotherapy is well-tolerated. No clinical, radiological or pathological predictive factors was identified for radiotherapy tumour response.PMID:37813717 | DOI:10.1016/j.canrad.2023.02.003 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 9, 2023 Category: Cancer & Oncology Authors: N Hanslik C Bourgier S Thezenas S Carr ère N Firmin O Riou D Azria C Llacer-Moscardo Source Type: research

Predictive factors assessment of pathological response to neoadjuvant radiotherapy of soft tissue sarcomas
CONCLUSIONS: Neoadjuvant radiotherapy is well-tolerated. No clinical, radiological or pathological predictive factors was identified for radiotherapy tumour response.PMID:37813717 | DOI:10.1016/j.canrad.2023.02.003 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 9, 2023 Category: Cancer & Oncology Authors: N Hanslik C Bourgier S Thezenas S Carr ère N Firmin O Riou D Azria C Llacer-Moscardo Source Type: research

Radiation therapy of the primary tumour and/or metastases of digestive metastatic cancers
Cancer Radiother. 2023 Oct 6:S1278-3218(23)00209-3. doi: 10.1016/j.canrad.2023.04.007. Online ahead of print.ABSTRACTMetastatic gastrointestinal cancer is not an uncommon situation, especially for pancreatic, gastric, and colorectal cancers. In this setting, few data are available on the impact of the treatment of the primary tumour. Oligometastatic disease is associated with longer survival in comparison with more advanced disease. Metastasis-directed therapy, such as stereotactic body radiotherapy, seems related to better outcomes, but the level of evidence is low. In most tumour locations, prospective data are very scar...
Source: Cancer Radiotherapie - October 8, 2023 Category: Cancer & Oncology Authors: F Huguet O Riou D Pasquier A Modesto L Qu éro M Michalet A Bordron B Schipman A Orthuon A Lisbona V Vendrely N Jaksic Source Type: research

Role of radiotherapy in the management of brain oligometastases
We present the recommendations of the French society of radiation oncology on the management of brain oligometastatic patients with radiotherapy.PMID:37802747 | DOI:10.1016/j.canrad.2023.03.005 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 6, 2023 Category: Cancer & Oncology Authors: D Antoni E Mesny O El Kabbaj S Josset G No ël J Biau L Feuvret I Latorzeff Source Type: research

Role of radiotherapy in the management of brain oligometastases
We present the recommendations of the French society of radiation oncology on the management of brain oligometastatic patients with radiotherapy.PMID:37802747 | DOI:10.1016/j.canrad.2023.03.005 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 6, 2023 Category: Cancer & Oncology Authors: D Antoni E Mesny O El Kabbaj S Josset G No ël J Biau L Feuvret I Latorzeff Source Type: research

Role of radiotherapy in the management of brain oligometastases
We present the recommendations of the French society of radiation oncology on the management of brain oligometastatic patients with radiotherapy.PMID:37802747 | DOI:10.1016/j.canrad.2023.03.005 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 6, 2023 Category: Cancer & Oncology Authors: D Antoni E Mesny O El Kabbaj S Josset G No ël J Biau L Feuvret I Latorzeff Source Type: research

Third whole-brain radiation therapy for multiple brain metastases. Should it be considered in selected patients?
Cancer Radiother. 2023 Sep 28:S1278-3218(23)00205-6. doi: 10.1016/j.canrad.2023.05.003. Online ahead of print.ABSTRACTWhole brain reirradiation for the treatment of multiple brain metastases has shown promising results. However, concerns remain over the possible neurotoxic effects of the cumulative dose as well as the questionable radiosensitivity of recurrent metastases. A second reirradiation of the whole brain is ordinarily performed in our department for palliative purposes in patients presenting with multiple metastatic brain progression. For this study, an investigational third whole brain reirradiation has been admi...
Source: Cancer Radiotherapie - September 30, 2023 Category: Cancer & Oncology Authors: L Lapadula M Piombino A Bianculli R Caivano A Capobianco A Cacciatore M Cozzolino C Oliviero B D'andrea A Mileo A Leone F Carbone N P Fochi M Landriscina A Colamaria G Giordano Source Type: research

Third whole-brain radiation therapy for multiple brain metastases. Should it be considered in selected patients?
Cancer Radiother. 2023 Sep 28:S1278-3218(23)00205-6. doi: 10.1016/j.canrad.2023.05.003. Online ahead of print.ABSTRACTWhole brain reirradiation for the treatment of multiple brain metastases has shown promising results. However, concerns remain over the possible neurotoxic effects of the cumulative dose as well as the questionable radiosensitivity of recurrent metastases. A second reirradiation of the whole brain is ordinarily performed in our department for palliative purposes in patients presenting with multiple metastatic brain progression. For this study, an investigational third whole brain reirradiation has been admi...
Source: Cancer Radiotherapie - September 30, 2023 Category: Cancer & Oncology Authors: L Lapadula M Piombino A Bianculli R Caivano A Capobianco A Cacciatore M Cozzolino C Oliviero B D'andrea A Mileo A Leone F Carbone N P Fochi M Landriscina A Colamaria G Giordano Source Type: research

Third whole-brain radiation therapy for multiple brain metastases. Should it be considered in selected patients?
Cancer Radiother. 2023 Sep 28:S1278-3218(23)00205-6. doi: 10.1016/j.canrad.2023.05.003. Online ahead of print.ABSTRACTWhole brain reirradiation for the treatment of multiple brain metastases has shown promising results. However, concerns remain over the possible neurotoxic effects of the cumulative dose as well as the questionable radiosensitivity of recurrent metastases. A second reirradiation of the whole brain is ordinarily performed in our department for palliative purposes in patients presenting with multiple metastatic brain progression. For this study, an investigational third whole brain reirradiation has been admi...
Source: Cancer Radiotherapie - September 30, 2023 Category: Cancer & Oncology Authors: L Lapadula M Piombino A Bianculli R Caivano A Capobianco A Cacciatore M Cozzolino C Oliviero B D'andrea A Mileo A Leone F Carbone N P Fochi M Landriscina A Colamaria G Giordano Source Type: research

Third whole-brain radiation therapy for multiple brain metastases. Should it be considered in selected patients?
Cancer Radiother. 2023 Sep 28:S1278-3218(23)00205-6. doi: 10.1016/j.canrad.2023.05.003. Online ahead of print.ABSTRACTWhole brain reirradiation for the treatment of multiple brain metastases has shown promising results. However, concerns remain over the possible neurotoxic effects of the cumulative dose as well as the questionable radiosensitivity of recurrent metastases. A second reirradiation of the whole brain is ordinarily performed in our department for palliative purposes in patients presenting with multiple metastatic brain progression. For this study, an investigational third whole brain reirradiation has been admi...
Source: Cancer Radiotherapie - September 30, 2023 Category: Cancer & Oncology Authors: L Lapadula M Piombino A Bianculli R Caivano A Capobianco A Cacciatore M Cozzolino C Oliviero B D'andrea A Mileo A Leone F Carbone N P Fochi M Landriscina A Colamaria G Giordano Source Type: research

Third whole-brain radiation therapy for multiple brain metastases. Should it be considered in selected patients?
Cancer Radiother. 2023 Sep 28:S1278-3218(23)00205-6. doi: 10.1016/j.canrad.2023.05.003. Online ahead of print.ABSTRACTWhole brain reirradiation for the treatment of multiple brain metastases has shown promising results. However, concerns remain over the possible neurotoxic effects of the cumulative dose as well as the questionable radiosensitivity of recurrent metastases. A second reirradiation of the whole brain is ordinarily performed in our department for palliative purposes in patients presenting with multiple metastatic brain progression. For this study, an investigational third whole brain reirradiation has been admi...
Source: Cancer Radiotherapie - September 30, 2023 Category: Cancer & Oncology Authors: L Lapadula M Piombino A Bianculli R Caivano A Capobianco A Cacciatore M Cozzolino C Oliviero B D'andrea A Mileo A Leone F Carbone N P Fochi M Landriscina A Colamaria G Giordano Source Type: research

Radiation-induced lymphopenia: Lymphocytes as a new organ at risk
Cancer Radiother. 2023 Sep;27(6-7):511-518. doi: 10.1016/j.canrad.2023.06.017. Epub 2023 Sep 1.ABSTRACTTaking the immune system into account in the fight against tumors has upset the cancer treatment paradigm in the 21st century. Combination treatment strategies associating radiotherapy with immunotherapy are being increasingly implemented in clinical practice. In this context, lymphocytes, whether lymphocytes infiltrating the tumour, circulating blood lymphocytes or lymphocytes residing within the lymph nodes, are key players in cellular and humoral anti-tumor immunity. The significant radiosensitivity of lymphocytes was ...
Source: Cancer Radiotherapie - September 4, 2023 Category: Cancer & Oncology Authors: P A Laurent É Deutsch Source Type: research

Radiation-induced lymphopenia: Lymphocytes as a new organ at risk
Cancer Radiother. 2023 Sep;27(6-7):511-518. doi: 10.1016/j.canrad.2023.06.017. Epub 2023 Sep 1.ABSTRACTTaking the immune system into account in the fight against tumors has upset the cancer treatment paradigm in the 21st century. Combination treatment strategies associating radiotherapy with immunotherapy are being increasingly implemented in clinical practice. In this context, lymphocytes, whether lymphocytes infiltrating the tumour, circulating blood lymphocytes or lymphocytes residing within the lymph nodes, are key players in cellular and humoral anti-tumor immunity. The significant radiosensitivity of lymphocytes was ...
Source: Cancer Radiotherapie - September 4, 2023 Category: Cancer & Oncology Authors: P A Laurent É Deutsch Source Type: research

Radiation-induced lymphopenia: Lymphocytes as a new organ at risk
Cancer Radiother. 2023 Sep;27(6-7):511-518. doi: 10.1016/j.canrad.2023.06.017. Epub 2023 Sep 1.ABSTRACTTaking the immune system into account in the fight against tumors has upset the cancer treatment paradigm in the 21st century. Combination treatment strategies associating radiotherapy with immunotherapy are being increasingly implemented in clinical practice. In this context, lymphocytes, whether lymphocytes infiltrating the tumour, circulating blood lymphocytes or lymphocytes residing within the lymph nodes, are key players in cellular and humoral anti-tumor immunity. The significant radiosensitivity of lymphocytes was ...
Source: Cancer Radiotherapie - September 4, 2023 Category: Cancer & Oncology Authors: P A Laurent É Deutsch Source Type: research

Radiation-induced lymphopenia: Lymphocytes as a new organ at risk
Cancer Radiother. 2023 Sep;27(6-7):511-518. doi: 10.1016/j.canrad.2023.06.017. Epub 2023 Sep 1.ABSTRACTTaking the immune system into account in the fight against tumors has upset the cancer treatment paradigm in the 21st century. Combination treatment strategies associating radiotherapy with immunotherapy are being increasingly implemented in clinical practice. In this context, lymphocytes, whether lymphocytes infiltrating the tumour, circulating blood lymphocytes or lymphocytes residing within the lymph nodes, are key players in cellular and humoral anti-tumor immunity. The significant radiosensitivity of lymphocytes was ...
Source: Cancer Radiotherapie - September 4, 2023 Category: Cancer & Oncology Authors: P A Laurent É Deutsch Source Type: research