Third whole-brain radiation therapy for multiple brain metastases. Should it be considered in selected patients?

Cancer Radiother. 2023 Sep 28:S1278-3218(23)00205-6. doi: 10.1016/j.canrad.2023.05.003. Online ahead of print.ABSTRACTWhole brain reirradiation for the treatment of multiple brain metastases has shown promising results. However, concerns remain over the possible neurotoxic effects of the cumulative dose as well as the questionable radiosensitivity of recurrent metastases. A second reirradiation of the whole brain is ordinarily performed in our department for palliative purposes in patients presenting with multiple metastatic brain progression. For this study, an investigational third whole brain reirradiation has been administered to highly selected patients to obtain disease control and delay progression. Clinical outcomes and neurological toxicity were also evaluated.PMID:37777371 | DOI:10.1016/j.canrad.2023.05.003

Source: Cancer Radiotherapie - September 30, 2023 Category: Cancer & Oncology Authors: L Lapadula M Piombino A Bianculli R Caivano A Capobianco A Cacciatore M Cozzolino C Oliviero B D'andrea A Mileo A Leone F Carbone N P Fochi M Landriscina A Colamaria G Giordano Source Type: research