Age-corrected hearing loss after chemoradiation in cervical cancer patients
ConclusionChemoradiation with cumulative cisplatin doses up to 400  mg did not lead to significant impairment of objective or subjective hearing. For cervical cancer patients undergoing chemoradiation, standard audiometry is not indicated. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 17, 2018 Category: Cancer & Oncology Source Type: research

Stereotactic radiotherapy for choroidal melanomas by means of HybridArc ™
ConclusionSRT of ocular tumours by HA is highly appropriate, and HA is superior to intensity-modulated arc therapy (IMAT) concerning dose reduction in organs at risk (OARs). The novel gradient measure SADG is more informative than Paddick ’s GI. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 16, 2018 Category: Cancer & Oncology Source Type: research

Evolution of adjuvant treatment in endometrial cancer —no evidence and new questions?
AbstractPurposeFor endometrial cancer (EC), clinical and pathological risk factors are taken to triage patients and estimate their prognosis. Lymph node involvement (pN+), lymphovascular space involvement (LSVI), grading, age of the patients, and T  classification are internationally accepted parameters for treatment decisions.Materials and methodsStudies on adjuvant radiation, chemotherapy, and chemoradiation are discussed against the background of risk stratification and clinical decision-making in early-to-advanced stage endometrial cancer. Recent publications on adjuvant treatment in high-risk disease and its impl...
Source: Strahlentherapie und Onkologie - August 15, 2018 Category: Cancer & Oncology Source Type: research

Unilateral cochlea sparing in locoregionally advanced head and neck cancer: a  planning study
ConclusionUnilateral cochlea sparing with an  MCD of less than 10 Gy is feasible without compromising the target volume or dose coverage in locoregionally advanced head and neck cancer patients treated with IMRT. A prospective evaluation of the clinical benefit of this approach as well as further investigation of the dose–response relati onship for future treatment modification appears promising. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 14, 2018 Category: Cancer & Oncology Source Type: research

Compensatory hypertrophy of the liver after external beam radiotherapy for primary liver cancer
AbstractPurposeWe investigated whether external beam radiotherapy (EBRT) could induce compensatory liver hypertrophy in liver cancers and assessed related clinical factors.MethodsA  total of 82 consecutive patients receiving EBRT for hepatocellular carcinoma (n = 77) or cholangiocarcinoma (n = 5) from April 2012 to June 2014 were recruited and divided into two subgroups according to tumor location in the right or left lobe. The left lateral and right lobes were considered as unirradiated volumes accordingly. Total liver volume (TLV), nontumor liver volume (NLV), left and right lobe whole volume ...
Source: Strahlentherapie und Onkologie - August 13, 2018 Category: Cancer & Oncology Source Type: research

Complementary medicine in radiation oncology
ConclusionToday, CAM is integrated into cancer care; however, skepticism regarding its effect still exists. Evidence-based results must be generated to convince physicians of the effectiveness of CAM methods. CAM qualifications must be included in physicians ’ training to improve their understanding and counseling regarding CAM options in cancer care. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 2, 2018 Category: Cancer & Oncology Source Type: research

The potential predictive value of tumor budding for neoadjuvant chemoradiotherapy response in locally advanced rectal cancer
This study was conducted to investigate the potential predictive value of tumor budding for neoadjuvant chemoradiotherapy response in locally advanced rectal cancer.Patients and methodsSurgical specimens of 128 ypUICC (Union for International Cancer Control) stage  0–III mid-to-low rectal cancer patients were identified from a prospectively maintained colorectal cancer database and classified into two groups using the 10 high-power field average method: none/mild tumor budding (BD-0) and moderate/severe tumor budding (BD-1). Overall survival, relapse-fre e survival (RFS), and recurrence estimates were ...
Source: Strahlentherapie und Onkologie - August 1, 2018 Category: Cancer & Oncology Source Type: research

Impact of postmastectomy radiotherapy on the outcomes of breast cancer patients with T1 –2 N1 disease
AbstractPurposeTo assess the impact of postmastectomy radiotherapy (PMRT) on overall survival and relapse-free survival among breast cancer patients with T1 –T2 N1 disease who received standard adjuvant systemic therapy.MethodsThis is an individual patient data pooled analysis of 1053 breast cancer patients referred for adjuvant therapy in three clinical trials (BIG  02/98, BCIRG001, and BCIRG005). Overall survival was assessed according to whether or not patients received adjuvant radiotherapy through Kaplan–Meier analysis. Univariate and multivariate analyses of predictors of overall and relapse-free sur...
Source: Strahlentherapie und Onkologie - August 1, 2018 Category: Cancer & Oncology Source Type: research

Pattern of care of adjuvant radiotherapy in male breast cancer patients in clinical practice: an observational study
ConclusionThe present observational study evaluated the pattern of care in male BC patients treated in clinical practice. Due to its rarity, randomized clinical trials are unlikely and male BC remains an entity with a  poor evidence base. Nevertheless, RT remains a crucial component of the multidisciplinary treatment strategy in male BC. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 25, 2018 Category: Cancer & Oncology Source Type: research

Radiotherapy, tumor mutational burden, and immune checkpoint inhibitors: time to do the math
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 20, 2018 Category: Cancer & Oncology Source Type: research

Accuracy assessment of a  potential clinical use of navigation-guided intra-operative liver metastasis brachytherapy—a planning study
AbstractFor patients with inoperable liver metastases, intra-operative liver high dose-rate brachytherapy (HDR-BT) is a  promising technology enabling delivery of a high radiation dose to the tumor, while sparing healthy tissue. Liver brachytherapy has been described in the literature as safe and effective for the treatment of primary or secondary hepatic malignancies. It is preferred over other ablative techniques for lesions that are either larger than 4 cm or located in close proximity to large vessels or the common bile duct. In contrast to external beam radiation techniques, organ movements do not affect t...
Source: Strahlentherapie und Onkologie - July 18, 2018 Category: Cancer & Oncology Source Type: research

Radiation-induced morphea —a rare but severe late effect of adjuvant breast irradiation
ConclusionsLittle is known about risk factors and pathogenesis of RIM. Here we describe the first case of RIM following immunotherapy. The diagnosis is based on clinical appearance and histopathological examination. Treatment should be initiated in the inflammatory stage in order to prevent or delay irreversible fibrosis and atrophy of the breast. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 16, 2018 Category: Cancer & Oncology Source Type: research

Prognostic factors in stereotactic body radiotherapy of lung metastases
AbstractPurposeThe aim of this study was to evaluate prognostic factors in patients with lung metastases who undergo lung stereotactic body radiotherapy (SBRT).Materials and methodsA total of 87  patients with 129 lung metastases who underwent SBRT between November 2004 and May 2012 were enrolled in this retrospective study. The patient collective consisted of 54 men (62.1%) and 33 women (37.9%); the median age was 65 years (range 36–88). The Karnofsky performance index was ≥70% ( median 90%) for all cases, but one (60%). Adverse effects were categorized using the CTCAE 4.0 class...
Source: Strahlentherapie und Onkologie - July 16, 2018 Category: Cancer & Oncology Source Type: research

Phase  II study of accelerated Linac-based SBRT in five consecutive fractions for localized prostate cancer
ConclusionsAccelerated SBRT for low-intermediate PC is feasible and well tolerated with comparable oncological outcome as described for other series with the same RT technique but treatment delivery on every other day. Longer follow-up is needed to the assess late toxicity profile and long-term clinical outcome. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 12, 2018 Category: Cancer & Oncology Source Type: research

Pattern of dysphagia after swallowing-sparing intensity-modulated radiotherapy (IMRT) of head and neck cancers: results of a  mono-institutional prospective study
AbstractBackground and purposeA  prospective instrumental assessment of late dysphagia using swallowing organs at risk (SWOARs)-sparing IMRT for nasopharyngeal and oropharyngeal cancers.Materials and methodsObjective instrumental assessment included fiberoptic endoscopic evaluation of swallowing (FEES) and videofluoroscopy (VFS) at baseline, and at 6 and 12  months after treatment. FEES assessed the pharyngeal residue according to the Farneti pooling score (P-score) as follows: 4–5 no dysphagia; 6–7 mild dysphagia; 8–9 moderate dysphagia; 10–11 severe dysphagia. Three different c...
Source: Strahlentherapie und Onkologie - July 9, 2018 Category: Cancer & Oncology Source Type: research

Cost analysis of a  wait-and-see strategy after radiochemotherapy in distal rectal cancer
ConclusionA  NOM strategy with an intensive surveillance using MRI and rectoscopy will produce costs that are expected to remain below those of immediate surgery. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 9, 2018 Category: Cancer & Oncology Source Type: research

Stellenwert der stereotaktischen Radiotherapie f ür das nichtresezierte Pankreaskarzinom
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 9, 2018 Category: Cancer & Oncology Source Type: research

Neoadjuvante Chemotherapie vor radikaler Hysterektomie beim Zervixkarzinom – Response ist nicht Überleben
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 9, 2018 Category: Cancer & Oncology Source Type: research

Radiation-induced acute toxicities after image-guided intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for patients with spinal metastases (IRON-1 trial)
ConclusionThis is the first randomized trial to evaluate radiation-induced toxicities after IMRT versus 3DCRT in patients with vertebral metastases. This trial demonstrated an additional improvement for IMRT in terms of acute side effects, although longer follow-up is required to further ascertain other endpoints. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 5, 2018 Category: Cancer & Oncology Source Type: research

Neoadjuvant chemotherapy for breast cancer —background for the indication of locoregional treatment
AbstractNeoadjuvant chemotherapy (NACT) has been widely adopted into the multidisciplinary management of breast cancer. The prognostic impact of treatment response has been clearly demonstrated. However, the impact of treatment response on the indication for adjuvant radiotherapy is unclear. This review summarizes important implications of NACT and treatment response on the risk of recurrence and locoregional multidisciplinary management from the standpoint of radiation oncology. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 4, 2018 Category: Cancer & Oncology Source Type: research

Einsatz alternativer Behandlungsmethoden bei Krebserkrankungen und Auswirkungen auf das Überleben
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 2, 2018 Category: Cancer & Oncology Source Type: research

MRI-based high-precision irradiation in an orthotopic pancreatic tumor mouse model
ConclusionAn MRI/CT-based treatment planning for high-precision IGRT using different techniques was established in an orthotopic pancreatic tumor model. Advanced radiation techniques allow considering perfect coverage of GTV and sparing of OARs in the preclinical setting and reflect clinical treatment plans of pancreatic cancer patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 11, 2018 Category: Cancer & Oncology Source Type: research

Hygienic aspects of marker pens in radiation therapy
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 7, 2018 Category: Cancer & Oncology Source Type: research

Lokoregionale Tiefenhyperthermie verbessert das krankheitsspezifische Gesamt überleben in Kombination mit einer neoadjuvanten Chemotherapie bei Hochrisiko-Weichteilsarkomen
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 7, 2018 Category: Cancer & Oncology Source Type: research

Adenocarcinoma of the oesophagus: neoadjuvant chemoradiation and radical surgery
ConclusionNeoadjuvant CRT in patients with AC of the oesophagus followed by thoracoabdominal surgery is a  locally very effective concept. A significant tumour regression in almost 75% of the patients may stimulate prospective trials on the omission of radical surgery for some elderly patients. Due to a high rate of distant metastases further investigations in terms of effective systemic therapy may be warranted. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 5, 2018 Category: Cancer & Oncology Source Type: research

Keine Überlegenheit der Protonentherapie gegenüber der IMRT beim lokal fortgeschrittenen NSCLC
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 1, 2018 Category: Cancer & Oncology Source Type: research

A  treatment planning study of prone vs. supine positions for locally advanced rectal carcinoma
ConclusionAll techniques provided superior sparing of OAR in the prone position. At higher radiation doses, treatment in prone position resulted in significant OAR protection, especially concerning small bowel sparing by RA and bladder sparing by 3D CRT. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 31, 2018 Category: Cancer & Oncology Source Type: research

Keine Verschlechterung der postoperativen Lebensqualit ät von Ösophaguskarzinompatienten durch neoadjuvante Radiochemotherapie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 30, 2018 Category: Cancer & Oncology Source Type: research

Automatic replanning of VMAT plans for different treatment machines: A  template-based approach using constrained optimization
ConclusionsAutomatic replanning of VMAT plans for a  different treatment machine by using pre-existing constraints as a template for a reoptimization is feasible and successful in terms of equal constraints. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 30, 2018 Category: Cancer & Oncology Source Type: research

Treatment planning for spinal radiosurgery
ConclusionsHigh plan quality for complex spinal radiosurgery was achieved among all systems and all participating centers in this planning challenge. This study concludes that simple IMAT techniques can generate significantly better plan quality compared to previous established CKRS benchmarks. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 25, 2018 Category: Cancer & Oncology Source Type: research

Non-coplanar VMAT combined with non-uniform dose prescription markedly reduces lung dose in breath-hold lung SBRT
ConclusionFor SBRT treatments in DIBH, a non-uniform dose prescription in the PTV, combined with a non-coplanar VMAT arc arrangement, significantly spares the ipsilateral lung while increasing dose to the GTV without major treatment time increase. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 25, 2018 Category: Cancer & Oncology Source Type: research

Factors predicting intolerance to definitive conventional radiotherapy in geriatric patients
ConclusionOverall, 19.3% of the elderly patients showed treatment intolerance during conventional radiotherapy. Serum albumin level and ECOG performance score should be considered as surrogate markers for radiotherapy interruption prior to the decision regarding definite conventional radiotherapy. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 24, 2018 Category: Cancer & Oncology Source Type: research

The impact of MRI steady-state sequences as an additional assessment modality in vestibular schwannoma patients after LINAC stereotactic radiotherapy or radiosurgery
ConclusionOur data confirmed the usefulness of SSS for anatomical segmentation of VS in LINAC-SRS/SRT treatment planning and add data supporting their potential as an adjunctive FU option in VS patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 23, 2018 Category: Cancer & Oncology Source Type: research

Local recurrence of breast cancer: conventionally fractionated partial external beam re-irradiation with curative intention
AbstractPurposeTo assess the outcome of breast cancer patients with local recurrence who underwent partial external beam re-irradiation (re-RT) either as part of a  second breast-conserving therapy or following mastectomy.MethodsBetween 03/2004 and 10/2016, 83  breast cancer patients with local recurrence were treated with surgery followed by re-RT. The re-RT schedules were 45 Gy (1.8 Gy per fraction) administered either to the partial breast (n = 42) or mastectomy scar (n = 41). The patients and tumor characteristics predictive of local control, distant control, and survival (overall and br...
Source: Strahlentherapie und Onkologie - May 23, 2018 Category: Cancer & Oncology Source Type: research

An offline technique to evaluate residual motion of the diaphragm during deep inspiratory breath-hold from cone-beam CT datasets
ConclusionsThe developed method allows an offline estimation of the inspiration depth (inter- and intra-breath-hold) over time. It will be useful as a  reference for comparison to other methods of residual motion estimation, e.g., surface scanning. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 22, 2018 Category: Cancer & Oncology Source Type: research

Kein Nachweis einer reduzierten Sp ättoxizität durch Dosisreduktion im elektiven Lymphknotenbereich in der primären Radiochemotherapie von Kopf-Hals-Tumoren
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 18, 2018 Category: Cancer & Oncology Source Type: research

Abstracts DEGRO 2018
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 17, 2018 Category: Cancer & Oncology Source Type: research

Tumor volume as a  prognostic marker in p16-positive and p16-negative oropharyngeal cancer patients treated with definitive intensity-modulated radiotherapy
ConclusionpGTV may serve as an independent prognostic factor in p16-negative patients and nGTV may serve as an independent prognostic factor both in p16-positive and p16-negative patients treated with radiochemotherapy or radiotherapy using IMRT. Tumor volume may have an impact on selecting patients for de-escalation protocols in the future, both in p16-positive and p16-negative patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 17, 2018 Category: Cancer & Oncology Source Type: research

Inclusion of dosimetric data as covariates in toxicity-related radiogenomic studies
ConclusionA large proportion of studies on the correlation of genetic markers with radiotherapy-related side effects considered no dosimetric parameters. Significance of dose distribution features was found in more than half of the studies including these features, emphasizing their importance. Completeness of radiation-specific clinical data may have increased in recent years which may improve gene-toxicity association studies. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 17, 2018 Category: Cancer & Oncology Source Type: research

Early versus late prophylactic cranial irradiation in patients with extensive small cell lung cancer
ConclusionTo reduce the incidence of brain metastases, early PCI is more effective than late PCI for ED-SCLC patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 17, 2018 Category: Cancer & Oncology Source Type: research

Patterns of care analysis for head & amp; neck cancer of unknown primary site: a  survey inside the German society of radiation oncology (DEGRO)
ConclusionDiagnostics and treatment for SCCHN  CUP within the DEGRO remain heterogeneous. A prospective register trial with standard operation procedures is warranted to homogenize and possibly improve management. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 14, 2018 Category: Cancer & Oncology Source Type: research

Absch ätzung von Langzeitrisiken der modernen Strahlentherapie bei Patientinnen mit Mammakarzinom: Evidenz zu Strahlendosen an Lunge und Herz
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 8, 2018 Category: Cancer & Oncology Source Type: research

Verl ängerung des rezidivfreien und Gesamtüberlebens beim Ovarialkarzinom im Stadium III durch hypertherme intraperitoneale Chemotherapie (HIPEC)
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 8, 2018 Category: Cancer & Oncology Source Type: research

Socioeconomic status and quality of life in patients with locally advanced head and neck cancer
ConclusionAfter IMRT for LAHNC, patients with high SES report worse QoL compared to patients with middle or low SES. There is a marked improvement within the first 24  months in many domains. However, the magnitude of improvement in patients with middle or low SES is significantly smaller compared to patients with high SES. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 7, 2018 Category: Cancer & Oncology Source Type: research

Linac-based stereotactic body radiation therapy for unresectable locally advanced pancreatic cancer: risk-adapted dose prescription and image-guided delivery
ConclusionIn our experience, risk-adapted dose prescription and image-guided SBRT represents an effective treatment option for LAPC patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 25, 2018 Category: Cancer & Oncology Source Type: research

Radiation-induced carotid artery lesions
ConclusionsRadiation-induced atherosclerosis is a  different and accelerated form of atherosclerosis, which implies a more aggressive disease with a different biologic behavior. The disease is characterized by a high rate of carotid artery stenosis compared to those observed in nonirradiated control group patients. To prevent the risk of stroke , surveillance and imaging with ultrasonography should enable detection of severe stenosis. Endovascular treatment with a carotid angioplasty and stenting has been proposed as an attractive and minimally invasive alternative for some radiation-induced stenos...
Source: Strahlentherapie und Onkologie - April 20, 2018 Category: Cancer & Oncology Source Type: research

Upregulated epithelial junction expression represents a  novel parameter of the epithelial radiation response to fractionated irradiation in oral mucosa
ConclusionFractionated irradiation significantly enhanced the expression of all proteins investigated. This study revealed a  new parameter of the epithelial radiation response to fractionated irradiation. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 19, 2018 Category: Cancer & Oncology Source Type: research

Fehlender Konsens bei Behandlungskonzepten f ür makroskopische Rezidive nach radikaler Prostatektomie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 18, 2018 Category: Cancer & Oncology Source Type: research

Polyfunctionality of CD4 + T  lymphocytes is increased after chemoradiotherapy of head and neck squamous cell carcinoma
AbstractBackgroundFor head and neck squamous cell cancer (HNSCC), standard therapy consists of surgery, radiation, and/or chemotherapy. Antineoplastic immunotherapy could be an option in an adjuvant setting and is already in palliation. A  functional immune system is a prerequisite for successful immunotherapy. However, effects of the standard-of-care therapy on the patients’ immune system are not fully understood.MethodsPeripheral blood mononuclear cells (PBMC) were collected from patients with HNSCC (n = 37) and healthy controls (n = 10). PBMC were stimulated with staphylococcal enteroto...
Source: Strahlentherapie und Onkologie - April 16, 2018 Category: Cancer & Oncology Source Type: research

Systemic administration of heparin ameliorates radiation-induced oral mucositis —preclinical studies in mice
ConclusionThese data provide the first evidence for a  protective and/or mitigative effect of heparins for radiation-induced oral mucositis. Further studies are ongoing investigating the underlying mechanism. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 16, 2018 Category: Cancer & Oncology Source Type: research