Prospective evaluation of multitarget treatment of pediatric patients with helical intensity-modulated radiotherapy
ConclusionOur results showed acceptable levels of acute and late toxicities, considering the highly advanced diseases and multimodal treatment. Hence, tomotherapy is a  feasible treatment method for young patients with anatomically complex tumors or multiple targets. Especially mtRT is a promising and innovative treatment approach for pediatric sarcomas, delivering unexpectedly high survival rates for patients with multifocal Ewing sarcomas in this study, whereb y the limited number of patients should invariably be considered in the interpretation. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 3, 2020 Category: Cancer & Oncology Source Type: research

Post-neoadjuvant treatment with capecitabine and trastuzumab emtansine in breast cancer patients —sequentially, or better simultaneously?
ConclusionRegarding oncologic outcome, the influence of sequencing radiation therapy with maintenance capecitabine chemotherapy in the post-neoadjuvant setting is unclear. Synchronous administration of capecitabine is feasible, but reports on possible excess toxicities are partially conflicting. Dose reduction of capecitabine should be considered, especially if normofractionated radiotherapy is used. In terms of tolerance, hypofractionated schedules seem to be superior in terms of toxicity in concurrent settings. T ‑DM1 can safely be administered concurrently with radiotherapy. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 31, 2020 Category: Cancer & Oncology Source Type: research

The role of different lymph node staging systems in predicting prognosis and determining indications for postmastectomy radiotherapy in patients with T1-T2pN1 breast carcinoma
ConclusionIn early-stage BC patients undergoing mastectomies, LN dissections and no PMRT, we propose LNR-based multivariable models to predict OS/LRFS with superior accuracy. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 24, 2020 Category: Cancer & Oncology Source Type: research

FAK inhibition radiosensitizes pancreatic ductal adenocarcinoma cells in vitro
ConclusionPharmacological inhibition of FAK in pancreatic cancer could be a  novel therapeutic strategy as our results show a radiosensitization effect of VS-4718 in vitro in a multicellular 2D- and in a 3D-model of pancreatic cancer. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 23, 2020 Category: Cancer & Oncology Source Type: research

EPAS1 promotes peritoneal carcinomatosis of non-small-cell lung cancer by enhancing mesothelial –mesenchymal transition
ConclusionEPAS1 promotes peritoneal carcinomatosis of NSCLC through enhancement of MMT and could therefore serve as a  prognostic marker or a therapeutic target in treating NSCLC, particularly in patients with peritoneal carcinomatosis. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 17, 2020 Category: Cancer & Oncology Source Type: research

The role of a  knowledge based dose–volume histogram predictive model in the optimisation of intensity-modulated proton plans for hepatocellular carcinoma patients
ConclusionA  knowledge-based RapidPlan model was trained and validated for IMPT. The results demonstrate that RapidPlan can be trained adequately for IMPT in HCC. The quality of the RapidPlan-based plans is at least equivalent compared to what is achievable with manual planning. RapidPlan also confirmed the po tential to optimise the quality of the proton therapy results, thus reducing the impact of operator planning skills on patient results. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 16, 2020 Category: Cancer & Oncology Source Type: research

Happy birthday, Klaus-R üdiger! Heartfelt appreciation on the occasion of the 80th birthday of Professor Klaus-Rüdiger Trott
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 16, 2020 Category: Cancer & Oncology Source Type: research

Radiation-induced DNA double-strand breaks in peripheral leukocytes and therapeutic response of heel spur patients treated by orthovoltage X-rays or a  linear accelerator
ConclusionLow-dose RT for painful heel spurs with orthovoltage X ‑rays or a 6-MV linac is an effective treatment option associated with a very low and comparable radiation burden to the patient, as confirmed by biodosimetric measurements. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 10, 2020 Category: Cancer & Oncology Source Type: research

Radiomics in radiation oncology —basics, methods, and limitations
AbstractOver the past years, the quantity and complexity of imaging data available for the clinical management of patients with solid tumors has increased substantially. Without the support of methods from the field of artificial intelligence (AI) and machine learning, a  complete evaluation of the available image information is hardly feasible in clinical routine. Especially in radiotherapy planning, manual detection and segmentation of lesions is laborious, time consuming, and shows significant variability among observers. Here, AI already offers techniques to su pport radiation oncologists, whereby ultimately, the ...
Source: Strahlentherapie und Onkologie - July 9, 2020 Category: Cancer & Oncology Source Type: research

Abstracts DEGRO 2020
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 9, 2020 Category: Cancer & Oncology Source Type: research

Treatment of low-risk prostate cancer: a  retrospective study with 477 patients comparing external beam radiotherapy and I-125 seeds brachytherapy in terms of biochemical control and late side effects
ConclusionBoth EBRT and seeds provide excellent biochemical control with bNED rates after 10  years of about 90%. In terms of side effects, patients treated with seeds show higher grades of genitourinary side effects, while patients treated with EBRT show higher grades of gastrointestinal side effects. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 8, 2020 Category: Cancer & Oncology Source Type: research

Evaluation of response using FDG-PET/CT and diffusion weighted MRI after radiochemotherapy of pancreatic cancer: a  non-randomized, monocentric phase II clinical trial—PaCa-DD-041 (Eudra-CT 2009-011968-11)
AbstractBackgroundPancreatic cancer is a  devastating disease with a 5-year survival rate of 20–25%. As approximately only 20% of patients diagnosed with pancreatic cancer are initially staged as resectable, it is necessary to evaluate new therapeutic approaches. Hence, neoadjuvant (radio)chemotherapy is a promising therapeutic option , especially in patients with a borderline resectable tumor. The aim of this non-randomized, monocentric, prospective, phase II clinical study was to assess the prognostic value of functional imaging techniques, i.e., [18F]2-fluoro-2-deoxy-d-glucose positron emi...
Source: Strahlentherapie und Onkologie - July 7, 2020 Category: Cancer & Oncology Source Type: research

Unterschiede in der Lebensqualit ät über 5 Jahre nach Therapie des lokal begrenzten Prostatakarzinoms mit verschiedenen Behandlungsoptionen
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 7, 2020 Category: Cancer & Oncology Source Type: research

Impact of intracavitary brachytherapy technique (2D versus 3D) on outcomes of cervical cancer: a  systematic review and meta-analysis
Conclusion3D-BT might reduce severe toxicity and improve LRRFS and PFS in patients with cervical cancer. 3D-BT should be considered for standard management of cervical cancer, and efforts for adopting this procedure in Korea should be pursued. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 6, 2020 Category: Cancer & Oncology Source Type: research

Hybrid TRUS/CT with optical tracking for target delineation in image-guided adaptive brachytherapy for cervical cancer
ConclusionHybrid TRUS-CT as an imaging modality for contouring the CTVHR in IGABT for LACC is feasible and reproducible among multiple observers. TRUS-CT substantially reduces overestimation of the CTVHR volume of CT alone while maintaining similar interobserver variability. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 3, 2020 Category: Cancer & Oncology Source Type: research

Dose –volume parameters of MRI-based active bone marrow predict hematologic toxicity of chemoradiotherapy for rectal cancer
ConclusionThe dose –volume parameters of BMact serve as better predictors of ALCnadir% and PLTnadir% than BMtot. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 3, 2020 Category: Cancer & Oncology Source Type: research

Treatment outcomes of metastasis-directed treatment using 68 Ga-PSMA-PET/CT for oligometastatic or oligorecurrent prostate cancer: Turkish Society for Radiation Oncology group study (TROD 09-002)
Conclusion68Ga-PSMA-PET/CT-based MDT is an efficient and safe treatment for oligometastatic PC patients. Proper patient selection might improve treatment outcomes. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 2, 2020 Category: Cancer & Oncology Source Type: research

Tumor-dose-rate variations during robotic radiosurgery of oligo and multiple brain metastases
AbstractPurposeFor step-and-shoot robotic stereotactic radiosurgery (SRS) the dose delivered over time, called local tumor-dose-rate (TDR), may strongly vary during treatment of multiple lesions. The authors sought to evaluate technical parameters influencing TDR and correlate TDR to clinical outcome.Material and methodsA total of 23  patients with 162 oligo (1–3) and multiple (>3) brain metastases (OBM/MBM) treated in 33  SRS sessions were retrospectively analyzed. Median PTV were 0.11 cc (0.01–6.36 cc) and 0.50 cc (0.12–3.68 cc) for OBM and MBM, respectively. Prescription dose range...
Source: Strahlentherapie und Onkologie - June 25, 2020 Category: Cancer & Oncology Source Type: research

Role of cancer stem cell markers ALDH1, BCL11B, BMI-1, and CD44 in the prognosis of advanced HNSCC
ConclusionAlthough validation in independent cohorts is still needed, testing for CSC markers in patients with advanced or late stage HNSCC might be beneficial, especially if many comorbidities exist or disease is irresectable. The findings might guide the development and earlier use of targeted therapies in the future. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 25, 2020 Category: Cancer & Oncology Source Type: research

Vielversprechende Langzeitergebnisse zum Einsatz von Anastrozol zur Pr ävention von Brustkrebs bei postmenopausalen Hochrisikopatientinnen
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 23, 2020 Category: Cancer & Oncology Source Type: research

A  randomized in vitro evaluation of transient and permanent cardiac implantable electronic device malfunctions following direct exposure up to 10 Gy
ConclusionApart from transient electromagnetic interference, last-generation CIEDs withstood direct 6 ‑MV exposure up to 10 Gy. Permanent battery or software errors occurred immediately or later only in less recent CIEDs. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 19, 2020 Category: Cancer & Oncology Source Type: research

Einfluss der Behandlungscompliance auf den Erfolg der Radiochemotherapie des Analkarzinoms
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 19, 2020 Category: Cancer & Oncology Source Type: research

Superoxiddismutasemimetikum (GC4419) vs. Placebo zur Reduktion von schweren oralen Mukositiden infolge simultaner Radiochemotherapie mit Cisplatin bei Kopf-Hals-Tumoren: randomisierte, doppelblinde Phase-IIb-Studie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 19, 2020 Category: Cancer & Oncology Source Type: research

Adjuvante Chemotherapie in der Behandlung der Urothelkarzinome des oberen Harntraktes
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 19, 2020 Category: Cancer & Oncology Source Type: research

Die Herzmortalit ät nach Strahlentherapie, Chemotherapie und endokriner Therapie des Mammakarzinoms
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 19, 2020 Category: Cancer & Oncology Source Type: research

Pembrolizumab in der neoadjuvanten Behandlung des fr ühen triple-negativen Mammakarzinoms
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 19, 2020 Category: Cancer & Oncology Source Type: research

The Prostate Cancer Outcomes (PCO) study in prostate cancer centres certified by the German Cancer Society
AbstractSince 2016, certified prostate cancer centres have been able to participate in the Prostate Cancer Outcomes (PCO) study. The aim of this study is to compare outcomes across centres after local treatment for prostate cancer. The study originated from a  support group initiative and is jointly carried out by the German Cancer Society (Deutsche Krebsgesellschaft), the certification institute OnkoZert, patient support groups and the participating centres. So far, centres have been more successful at recruiting patients undergoing surgery than those receiving radiotherapy as the definitive treatment. This means tha...
Source: Strahlentherapie und Onkologie - June 16, 2020 Category: Cancer & Oncology Source Type: research

Radiochemotherapy with or without cetuximab for unresectable esophageal cancer: final results of a  randomized phase 2 trial (LEOPARD-2)
ConclusionGiven the limitations of this trial, radiochemotherapy plus cetuximab was feasible. There was a  trend towards improved PFS and MFS. Larger studies are required to better define the role of cetuximab for unresectable esophageal cancer. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 12, 2020 Category: Cancer & Oncology Source Type: research

Induktionschemotherapie mit Cisplatin und Gemcitabin, gefolgt von Radiochemotherapie bei Nasopharynxkarzinomen
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 10, 2020 Category: Cancer & Oncology Source Type: research

Systemic modulation of stress and immune parameters in patients treated for prostate adenocarcinoma by intensity-modulated radiation therapy or stereotactic ablative body radiotherapy
ConclusionLocally delivered RT induces systemic modulation of the immune system in prostate adenocarcinoma patients. IMRT and SABR appear to specifically affect distinct immune components. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 9, 2020 Category: Cancer & Oncology Source Type: research

Stellenwert der Hippocampusschonung bei therapeutischer Ganzhirnbestrahlung
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 9, 2020 Category: Cancer & Oncology Source Type: research

Long-term outcomes and safety after reirradiation in locally recurrent nasopharyngeal carcinoma in a  non-endemic area
ConclusionReirradiation of rNPC is an effective treatment but is associated with a  high rate of life-threatening toxicity. Stratification of patients based on their risk of developing severe toxicity is needed to select patients who will most likely benefit from re-RT. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 8, 2020 Category: Cancer & Oncology Source Type: research

Zeitliche Abfolge der Androgendeprivation und externen Strahlenbehandlung beim lokal begrenzten Prostatakarzinom: eine randomisierte, kontrollierte Phase-III-Studie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 7, 2020 Category: Cancer & Oncology Source Type: research

Zielvolumenreduktion durch 18 F-FDG-PET/CT-basierte „involved field“ Bestrahlung beim fortgeschrittenen NSCLC möglicherweise neuer Standard: Ergebnisse der PET-Plan-Studie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 6, 2020 Category: Cancer & Oncology Source Type: research

Radiomic biomarkers for head and neck squamous cell carcinoma
AbstractTumor heterogeneity is a  well-known prognostic factor in head and neck squamous cell carcinoma (HNSCC). A major limitation of tissue- and blood-derived tumor markers is the lack of spatial resolution to image tumor heterogeneity. Tissue markers derived from tumor biopsies usually represent only a small tumor subregion a t a single timepoint and are therefore often not representative of the tumors’ biology or the biological alterations during and after treatment. Similarly, liquid biopsies give an overall picture of the tumors’ secreted factors but completely lack any spatial resolut...
Source: Strahlentherapie und Onkologie - June 3, 2020 Category: Cancer & Oncology Source Type: research

Evaluation of automatic VMAT plans in locally advanced nasopharyngeal carcinoma
ConclusionThe selection of manual versus automatic VMAT planning in locally advanced NPC should be made individually based on the anatomic distance, rather than blindly and habitually, since automatic VMAT is not good enough to completely replace manual VMAT. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 2, 2020 Category: Cancer & Oncology Source Type: research

Effect of hypofractionation on the incidental axilla dose during tangential field radiotherapy in breast cancer
ConclusionOur data indicate that hypofractionation might affect the effectiveness of incidental radiotherapy in the axilla. This is particularly relevant for patients with positive sentinel lymph nodes who receive SLNB only. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 2, 2020 Category: Cancer & Oncology Source Type: research

Effectiveness of rectal displacement devices in managing prostate motion: a  systematic review
ConclusionUsing an ERB significantly reduces intra-fractional prostate motion. This prostate-stabilizing effect of the ERB can translate into reduced planning target volume (PTV) margins and additional rectal dose sparing. Even with an ERB in place, inter-fractional prostate displacements are seen. As a  consequence, ERB application does not obviate daily verification; however, this is not a crucial topic because pretreatment imaging is always done nowadays. As compared with ERB, the hydrogel spacer significantly reduces rectal dose and toxicity without influencing prostate immobilization. The RR can increase pro...
Source: Strahlentherapie und Onkologie - May 22, 2020 Category: Cancer & Oncology Source Type: research

Impact of 18 F-FDG-PET/CT on the identification of regional lymph node metastases and delineation of the primary tumor in esophageal squamous cell carcinoma patients
This study aimed to analyze patterns of lymph node metastases and their correlation with the primary tumor using18F ‑fludeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans.Methods102 ESCC patients with pre-treatment FDG-PET/CT scans were evaluated retrospectively. After exclusion of patients with low FDG uptake and patients without FDG-PET-positive lymph node metastases (LNM), 76  patients were included in the final analysis. All LNM were assigned to 16 pre-defined anatomical regions and classified according to their position relative to the primary tumor (above, at the same height,...
Source: Strahlentherapie und Onkologie - May 19, 2020 Category: Cancer & Oncology Source Type: research

The brave new world of endometrial cancer
ConclusionThe aim of the new classification is a  more personalized adjuvant radio(chemo)therapy decision and better oncologic outcomes or avoidance of overtreatment. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 19, 2020 Category: Cancer & Oncology Source Type: research

Efficacy of repeated PSMA PET-directed radiotherapy for oligorecurrent prostate cancer after initial curative therapy
AbstractPurposeTo assess the outcome of prostate cancer (PCa) patients diagnosed with oligorecurrent disease and treated with a  first and a second PSMA (prostate-specific membrane antigen ligand) PET(positron-emission tomography)-directed radiotherapy (RT).Patients and methodsThirty-two patients with oligorecurrent relapse after curative therapy received a  first PSMA PET-directed RT of all metastases. After biochemical progression, all patients received a second PSMA PET-directed RT of all metastases. The main outcome parameters were biochemical progression-free survival (bPFS) and androgen deprivatio...
Source: Strahlentherapie und Onkologie - May 12, 2020 Category: Cancer & Oncology Source Type: research

Linac-based SBRT as a  feasible salvage option for local recurrences in previously irradiated prostate cancer
AbstractBackground and objectiveThe optimal management of prostate cancer (PC) recurrences after definitive or postoperative radiotherapy (RT) is still controversial. The aim of the present retrospective study was to report the preliminary clinical results and toxicity of a  mono-institutional series of patients re-irradiated with linac-based SBRT in recurrent prostate cancer.MethodsInclusion criteria were previous definitive or adjuvant/salvage RT, evidence of biochemical recurrence and radiological detection of local relapse (Magnetic Resonance Imaging or PSMA/choline-Positron Emission Tomography), and IPSS
Source: Strahlentherapie und Onkologie - May 12, 2020 Category: Cancer & Oncology Source Type: research

Disease course of lung oligometastatic colorectal cancer treated with stereotactic body radiotherapy
ConclusionThe present results support local ablative treatment of lung metastases using SBRT in oligometastatic colorectal cancer patients, as it can delay the transition to PMD. Patients who progressed as SOMD maintained a  survival advantage compared to those who developed PMD. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 12, 2020 Category: Cancer & Oncology Source Type: research

Applications of radiomics and machine learning for radiotherapy of malignant brain tumors
ConclusionClinical application of automated image analyses based on radiomics and artificial intelligence has a  great potential for improving radiotherapy in patients with malignant brain tumors. However, a common problem associated with these techniques is the large variability and the lack of standardization of the methods applied. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 11, 2020 Category: Cancer & Oncology Source Type: research

Low-dose radiotherapy for SARS-CoV-2 pneumonia
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 11, 2020 Category: Cancer & Oncology Source Type: research

Low-dose radiation therapy for COVID-19 pneumopathy: what is the evidence?
AbstractIn the current dismal situation of the COVID-19 pandemic, effective management of patients with pneumonia and acute respiratory distress syndrome is of vital importance. Due to the current lack of effective pharmacological concepts, this situation has caused interest in (re)considering historical reports on the treatment of patients with low-dose radiation therapy for pneumonia. Although these historical reports are of low-level evidence per se, hampering recommendations for decision-making in the clinical setting, they indicate effectiveness in the dose range between 0.3 and 1  Gy, similar to more recent dose co...
Source: Strahlentherapie und Onkologie - May 9, 2020 Category: Cancer & Oncology Source Type: research

Oncological outcome and recurrence pattern analysis after involved-field irradiation in combination with rituximab for early-stage nodal and extranodal follicular lymphoma
ConclusionThe real-world efficacy of RIT is comparable with the results of the MIR study. Additionally, this analysis shows that extranodal involvement and grade 3A  histology are not associated with inferior PFS. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 6, 2020 Category: Cancer & Oncology Source Type: research

Radiotherapy of the oldest old —feasibility and institutional analysis
ConclusionThe number of older cancer patients will increase considerably in the next decades because of demographic changes. Our analysis supports the notion that radiation therapy for this patient group of oldest old cancer patients is feasible in general. Treatment decisions should not be based on chronological age but rather on comorbidities and functional status. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 4, 2020 Category: Cancer & Oncology Source Type: research

Quality of teaching radiation oncology in Germany —where do we stand?
ConclusionRO plays an integral but underrepresented role in clinical medical education in Germany, but faces new challenges in the development of practical and competence-based education, which will require further innovative and interdisciplinary concepts. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 4, 2020 Category: Cancer & Oncology Source Type: research

Radiomics and deep learning in lung cancer
AbstractLung malignancies have been extensively characterized through radiomics and deep learning. By providing a  three-dimensional characterization of the lesion, models based on radiomic features from computed tomography (CT) and positron-emission tomography (PET) have been developed to detect nodules, distinguish malignant from benign lesions, characterize their histology, stage, and genotype. Deep learnin g models have been applied to automatically segment organs at risk in lung cancer radiotherapy, stratify patients according to the risk for local and distant recurrence, and identify patients candidate for molec...
Source: Strahlentherapie und Onkologie - May 4, 2020 Category: Cancer & Oncology Source Type: research