Phase-II-Studie zur Therapiedeeskalation bei HPV-assoziierten Oropharynxkarzinomen. Kommentar  II
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 13, 2022 Category: Cancer & Oncology Source Type: research

Propensity score-matched analysis comparing dose-escalated intensity-modulated radiation therapy versus external beam radiation therapy plus high-dose-rate brachytherapy for localized prostate cancer
ConclusionBoth treatment groups showed excellent long-term outcomes with low rates of severe toxicity. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 12, 2022 Category: Cancer & Oncology Source Type: research

Symptom relief, prognostic factors, and outcome in patients receiving urgent radiation therapy for superior vena cava syndrome
ConclusionSymptom relief by urgent RT for SVCS was achieved in the majority of patients. RT dose and completion of the RT course were documented as predictors for OS and symptom relief, CTV  <  387 ml and concomitant chemotherapy were predictive for OS. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 12, 2022 Category: Cancer & Oncology Source Type: research

Long-term neurocognitive function after whole-brain radiotherapy in patients with melanoma brain metastases in the era of immunotherapy
ConclusionFive of 8 long-term survivors with MBM after WBRT experienced little to no restriction in everyday activities. In 3 out of 8  patients, cognitive decline was primarily explained by localization of the metastases in functionally relevant areas of the brain. The results of our small patient cohort do not support general avoidance of WBRT for treatment of brain metastases. However, long-term studies including pretreatment N CF tests are needed to fully analyze the long-term neurocognitive effects of WBRT (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 11, 2022 Category: Cancer & Oncology Source Type: research

Oligometastasis in breast cancer —current status and treatment options from a radiation oncology perspective
AbstractEvidence from a  few small randomized trials and retrospective cohorts mostly including various tumor entities indicates a prolongation of disease free survival (DFS) and overall survival (OS) from local ablative therapies in oligometastatic disease (OMD). However, it is still unclear which patients benefit most from this approach. We give an overview of the several aspects of stereotactic body radiotherapy (SBRT) in extracranial OMD in breast cancer from a radiation oncology perspective. A PubMed search referring to this was conducted. An attempt was made to relate the therapeutic efficacy of SBRT to var ious ...
Source: Strahlentherapie und Onkologie - May 8, 2022 Category: Cancer & Oncology Source Type: research

Radio(chemo)therapy in anaplastic thyroid cancer —high locoregional but low distant control rates—a monocentric analysis of a tertiary referral center
ConclusionDepending on UICC stage, RT with high radiation dose can lead to improved OS or at least higher locoregional control. A limiting factor is the high incidence of distant metastases; therefore modern systemic treatment options should be integrated into multimodal therapy concepts. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 6, 2022 Category: Cancer & Oncology Source Type: research

37.  Jahrestagung der Österreichischen Gesellschaft für Radioonkologie, Radiobiologie und Medizinische Radiophysik
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 4, 2022 Category: Cancer & Oncology Source Type: research

The use of radiosensitizing agents in the therapy of glioblastoma multiforme —a comprehensive review
ConclusionIn the history of glioblastoma treatment, several approaches of optimizing radiation-effectiveness using radiosensitizers have been made. Even though several different strategies and agents have been explored, clear evidence of improved patient outcome is still missing. Tissue-selectiveness and penetration of the blood –brain barrier seem to be major roadblocks; nevertheless, modern strategies try to circumvent these obstacles, using novel sensitizers based on preclinical data or alternative ways of delivery. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 3, 2022 Category: Cancer & Oncology Source Type: research

Impact of a  ketogenic diet intervention during radiotherapy on body composition: V. Final results of the KETOCOMP study for head and neck cancer patients
ConclusionThe KD may partially counteract the detrimental effects of radiochemotherapy on body composition in HNC patients. This should encourage further research into KDs in frail cancer patient populations and motivate their implementation as complementary therapy for selected patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 2, 2022 Category: Cancer & Oncology Source Type: research

Whole breast radiotherapy in cN0 early breast cancer patients with pathological sentinel lymph nodes (pN1mic, pN1a) without axillary dissection: preliminary results of the observational LISEN trial
ConclusionOur results showed good regional control in patients who met the Z0011 trial criteria. WBRT, without nodal surgery or RT, avoiding axillary morbidity, seems to be a  good choice. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 2, 2022 Category: Cancer & Oncology Source Type: research

Stereotactic body radiotherapy for pulmonary oligometastases: a  monoinstitutional analysis of clinical outcomes and potential prognostic factors
ConclusionSBRT is feasible for pulmonary oligometastases with favorable outcomes and toxicity. At multivariate analysis, patients with sequential oligometastatic progression maintain a  survival advantage. Also, local control was found to be related to improved PFS rates. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 2, 2022 Category: Cancer & Oncology Source Type: research

Digital transfer in radiation oncology education for medical students —single-center data and systemic review of the literature
ConclusionThe analysis demonstrates the possibility of efficient digital transfer of a  core curriculum in RO to the digital era, with a more continuous participation of students. This transfer may enable amelioration of teaching quality and the introduction of innovative and interactive concepts in accordance with the literature. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 29, 2022 Category: Cancer & Oncology Source Type: research

Effect of plan complexity on the dosimetry, delivery accuracy, and interplay effect in lung VMAT SBRT with 6  MV FFF beam
ConclusionFor lung VMAT SBRT, LC plans have a  higher delivery accuracy and a lower motion-induced dose deviation with similar dosimetry compared with HC plans. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 29, 2022 Category: Cancer & Oncology Source Type: research

Abstracts DEGRO 2022
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 28, 2022 Category: Cancer & Oncology Source Type: research

Chemotherapiebedingte kognitive Beeintr ächtigungen bei Mammakarzinompatientinnen – Risikofaktoren und Therapie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 28, 2022 Category: Cancer & Oncology Source Type: research