Neoadjuvante Radiochemotherapie verbessert bei resektablen und grenzwertig resezierbaren Pankreaskarzinomen die onkologischen Ergebnisse, bei resezierbaren aber nicht das Gesamt überleben
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 30, 2020 Category: Cancer & Oncology Source Type: research

Randomisierte Phase-IIB-Studie zur Protonentherapie vs. intensit ätsmodulierte Photonentherapie für lokal fortgeschrittene Ösophaguskarzinome
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 30, 2020 Category: Cancer & Oncology Source Type: research

Revisiting the formalism of equivalent uniform dose based on the linear-quadratic and universal survival curve models in high-dose stereotactic body radiotherapy
ConclusionA  uniform formalism of EUD should be defined among the SBRT community in order to apply it as a single metric for dose reporting and dose–response modeling in high-dose-gradient SBRT because its value depends on the underlying cell survival model and the model parameters. Further investigations o f the optimal formalism to derive the EUD through clinical correlations are warranted. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 27, 2020 Category: Cancer & Oncology Source Type: research

Das ereignisfreie Überleben als Endpunkt, der unter anderem den PSA-Verlauf einbezieht, ist kein Surrogat für das Gesamtüberleben nach Strahlenbehandlung eines lokalisierten Prostatakarzinoms
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 26, 2020 Category: Cancer & Oncology Source Type: research

The course of lung oligometastatic colorectal cancer may be a  reflection of selection for treatment rather than an effect of stereotactic body radiotherapy
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 26, 2020 Category: Cancer & Oncology Source Type: research

Die lokoregionale Radiotherapie verl ängert beim de novo metastasierten Nasopharynxkarzinom das Überleben signifikant
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 26, 2020 Category: Cancer & Oncology Source Type: research

Reply to: The course of lung oligometastatic colorectal cancer may be a  reflection of selection for treatment rather than an effect of stereotactic body radiotherapy
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 26, 2020 Category: Cancer & Oncology Source Type: research

Radiotherapy and COVID-19 —everything under control or just the start of a long story?
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 25, 2020 Category: Cancer & Oncology Source Type: research

Interobserver agreement between interpretations of acute changes after lung stereotactic body radiotherapy
ConclusionDisciplines dealing with lung cancer treatment may not be aware of the various radiologic changes after SBRT or inexperienced in interpreting them from recurrence. Therefore, physicians must have detailed radiotherapy information such as planning target volume (PTV), dose/fractionation, etc. In addition, final evaluations should be performed in the multidisciplinary team dealing with the treatment of the patient (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 24, 2020 Category: Cancer & Oncology Source Type: research

Synergistic effect of PAF inhibition and X-ray irradiation in non-small cell lung cancer cells
ConclusionThese data demonstrate that reduced expression of PAF enhances radiosensitivity in NSCLC cells. Mechanistically, inhibition of the MEK/ERK and Wnt/ β-catenin signaling pathways caused by PAF interference may lead to impaired cell function and enhance sensitivity to X‑rays. Targeting PAF may therefore serve as a potential therapeutic strategy to increase the efficiency of radiotherapy in NSCLC patients, ultimately improving patient survival. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 24, 2020 Category: Cancer & Oncology Source Type: research

Radiation oncology as part of medical education —current status and possible digital future prospects
ConclusionTraditional seminars enjoy a  high level of acceptance among students. Effectiveness with regard to the internalization of content taught, however, should be increased. After all, the future seems to lie in the integration of e‑learning in the form of educational videos and practical seminars. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 23, 2020 Category: Cancer & Oncology Source Type: research

Pretreatment central quality control for craniospinal irradiation in non-metastatic medulloblastoma
ConclusionThis prospective pretreatment individual case review study revealed a  high rate of deviations and emphasizes the strong need of pretreatment RT-QC in clinical trials for medulloblastoma. Furthermore, the experiences point out the necessity of new RT-QC criteria for high-precision CSI techniques. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 23, 2020 Category: Cancer & Oncology Source Type: research

Routine restaging after primary non-surgical treatment of laryngeal squamous cell carcinoma —a review
ConclusionStudies evaluating restaging methods after organ-preserving non-surgical treatment of laryngeal carcinoma are limited. As radiotherapy (RT), chemoradiotherapy (CRT), systemic therapy followed by RT and radioimmunotherapy are established alternatives to surgical treatment, particularly in advanced laryngeal cancers, further studies are needed to assess and compare different imaging modalities (e.g. PET/CT, MRI, CT, ultrasound) and clinical diagnostic tools (e.g., video laryngoscopy, direct laryngoscopy) to offer patients safe and efficient restaging strategies. PET or PET/CT 3  months after initial treatment ...
Source: Strahlentherapie und Onkologie - November 20, 2020 Category: Cancer & Oncology Source Type: research

Quality of life and fatigue before and after radiotherapy in breast cancer patients
ConclusionPatients undergoing postoperative RT for breast cancer constitute a  heterogeneous patient population with varying risks of developing CRF influenced by previous treatments. Therefore, patient selection seems to be critical when interventional studies addressing CRF during radiotherapy are designed. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 19, 2020 Category: Cancer & Oncology Source Type: research

Radiation treatment of hemato-oncological patients in times of the COVID-19 pandemic
ConclusionRT for hemato-oncological patients receives high-priority and should be maintained even in later stages of the pandemic. Hypofractionation and shortened treatment schedules are feasible options for well-defined constellations, but have to be discussed in the clinical context. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 30, 2020 Category: Cancer & Oncology Source Type: research

Managing patient flows in radiation oncology during the COVID-19 pandemic
ConclusionIn times of reduced medical infrastructure capacities and resources, controlling infrastructural time per patient as well as optimizing facility utilization and personnel workload during treatment evaluation, planning, and irradiation can help to improve appointment compliance and quality management. Avoiding recurrent and preventable exposure to healthcare infrastructure has potential health benefits and might avert cross infections during the pandemic. Active patient flow management in high-risk COVID-19 regions can help Radiation Oncologists to continue and initiate treatments safely, instead of cancelling and...
Source: Strahlentherapie und Onkologie - October 29, 2020 Category: Cancer & Oncology Source Type: research

[F18] FDG-PET/CT for manual or semiautomated GTV delineation of the primary tumor for radiation therapy planning in patients with esophageal cancer: is it useful?
ConclusionWe were not able to show that the integration of PET/CT for GTV delineation of the primary tumor resulted in reduced interobserver variability. The PERCIST-TLG algorithm seemed most promising compared to other thresholds for further evaluation of semiautomated delineation of esophageal cancer. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 26, 2020 Category: Cancer & Oncology Source Type: research

Implementation of a  dedicated 1.5 T MR scanner for radiotherapy treatment planning featuring a novel high-channel coil setup for brain imaging in treatment position
ConclusionWe present a  novel setup for high-quality imaging in treatment position that allows use of several immobilization systems enabling MR-only workflows, which could reduce unnecessary dose and registration inaccuracies. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 25, 2020 Category: Cancer & Oncology Source Type: research

Matched-pair dosimetric comparison of cardiac radiation exposure between deep-inspiration breath-hold whole-breast radiation therapy with Active Breathing Coordinator and interstitial multicatheter high-dose-rate brachytherapy as accelerated partial breast irradiation in adjuvant treatment of left-sided breast cancer after breast-conserving surgery
ConclusionABC-WBRT and imHDR-APBI yield similar low heart and LV exposure for left-sided BCA after BCS, whereas LAD can be better spared with imHDR-APBI. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 19, 2020 Category: Cancer & Oncology Source Type: research

Hybrid volumetric modulated arc therapy for hypofractionated radiotherapy of breast cancer: a  treatment planning study
This study aims to evaluate the best possible practice using hybrid volumetric modulated arc therapy (H-VMAT) for hypofractionated radiation therapy of breast cancer. Different combinations of H ‑VMAT—a combination of three-dimensional radiotherapy (3D-CRT) and VMAT—were analyzed regarding planning target volume (PTV), dose coverage, and exposure to organs at risk (OAR).MethodsPlanning computed tomography scans were acquired in deep-inspiration breath-hold. A  total of 520 treatment plans were calculated and evaluated for 40 patients, comprising six different H‑VMAT plans and a 3D-CRT pl...
Source: Strahlentherapie und Onkologie - October 17, 2020 Category: Cancer & Oncology Source Type: research

Cardiac doses of accelerated partial breast irradiation with perioperative multicatheter interstitial brachytherapy
ConclusionPerioperative MIB-APBI resulted in low cardiac doses in our study. This finding provides further support for the value of this technique in well-selected patients with early-stage left breast cancer. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 16, 2020 Category: Cancer & Oncology Source Type: research

Performance assessment of two motion management systems for frameless stereotactic radiosurgery
ConclusionTranslational motion can be accurately and sensitively detected by OSMS and HDMM real-time monitoring systems. However, performance variations were observed along different motion directions, as well as amongst the selection of reference images. Caution is needed when using real-time monitoring systems for frameless SRS treatment. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 12, 2020 Category: Cancer & Oncology Source Type: research

Incorporating dose –volume histogram parameters of swallowing organs at risk in a videofluoroscopy-based predictive model of radiation-induced dysphagia after head and neck cancer intensity-modulated radiation therapy
ConclusionWe trained and cross-validated an  RID predictive model with high discriminative ability at both 6 and 12 months after RT. We expect to improve the predictive power of this model by enlarging the number of training datasets. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 9, 2020 Category: Cancer & Oncology Source Type: research

An easy way to determine bone mineral density and predict pelvic insufficiency fractures in patients treated with radiotherapy for cervical cancer
AbstractPurposeThe aim of this study was to investigate whether bone mineral density (BMD) as measured in planning computed tomographies (CTs) by a  new method is a risk factor for pelvic insufficiency fractures (PIF) after radio(chemo)therapy (R(C)T) for cervical cancer.Methods62  patients with cervical cancer who received definitive or adjuvant radio(chemo)therapy between 2013 and 2017 were reviewed. The PIF were detected on follow-up magntic resonance imaging (MRI). The MRI of the PIF patients was registered to the planning CT and the PIF contoured. On the contralateral s ide of the fracture, a mirro...
Source: Strahlentherapie und Onkologie - October 5, 2020 Category: Cancer & Oncology Source Type: research

Kognitive Einschr änkungen bei Patientinnen mit Brustkrebs in Frühstadien durch adjuvante Systemtherapien – Ergebnisse einer Substudie der TAILORx-Studie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2020 Category: Cancer & Oncology Source Type: research

Relevanz einer adjuvanten Ganzhirnbestrahlung nach lokaler Therapie von ein bis 3  Hirnmetastasen eines systemisch metastasierten malignen Melanoms
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2020 Category: Cancer & Oncology Source Type: research

Moderate hypofractionated radiotherapy for post-operative treatment of prostate cancer: long-term outcome and pattern of toxicity
ConclusionOur results confirm the long-term safety and efficacy of postoperative MHRT for PC.Advances in knowledgeThe present paper demonstrates the long-term safety and efficacy of MHRT for postoperative prostate cancer. Reduction of treatment time in long-course radiotherapy has advantages in terms of both patients ’ quality of life and departmental organization. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 30, 2020 Category: Cancer & Oncology Source Type: research

Adjuvant hypofractionated radiotherapy with simultaneous integrated boost after breast-conserving surgery: results of a  prospective trial
ConclusionThis study demonstrated low toxicity of and high treatment adherence to hypofractionated adjuvant radiotherapy with SIB in a  multicenter prospective trial, although the primary hypothesis was not met. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 30, 2020 Category: Cancer & Oncology Source Type: research

Ist die Protonenbestrahlung der Photonenbestrahlung im Hinblick auf das neurokognitive Outcome überlegen?
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 29, 2020 Category: Cancer & Oncology Source Type: research

Inzidenz und Beginn schwerer kardialer Ereignisse nach der Strahlentherapie von Ösophaguskarzinomen
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 29, 2020 Category: Cancer & Oncology Source Type: research

Long-term results of robotic radiosurgery for non brachytherapy patients with cervical cancer
ConclusionBrachytherapy remains the standard of care for patients diagnosed with cervical cancer and indication for primary chemoradiation. In terms of local control, CyberKnife ®-based boost concepts provide excellent local control. It can be an alternative for patients who cannot receive adequate brachytherapy. Distant relapse still remains a challenge in this context. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 23, 2020 Category: Cancer & Oncology Source Type: research

Dose coverage impacts local control in ultra-central lung oligometastases treated with stereotactic radiotherapy
AbstractIntroductionThe use of Stereotactic Body Radiotherapy (SBRT) is controversial in Ultra-Central lung tumors, a subset of central lung tumors characterized by proximity to critical mediastinal structures. This is of interest in oligometastatic ( ≤3 metastases) patients, who can yield survival benefit from local treatments. The aim of our study is to assess the determinants of efficacy and toxicity in this setting.Materials and methodsClinical and dosimetric parameters were reviewed in a cohort of oligometastatic patients treated with SBRT for ultra-central tumors. Local control rate (LC) and toxicity were assessed...
Source: Strahlentherapie und Onkologie - September 23, 2020 Category: Cancer & Oncology Source Type: research

Results of a  randomized controlled phase III trial: efficacy of polyphenol-containing cystus® tea mouthwash solution for the reduction of mucositis in head and neck cancer patients undergoing external beam radiotherapy
ConclusionCystus ® and sage tea have a similar effect on the occurrence of radiation-induced mucositis regarding latency and incidence. Cystus® tea mouthwash solution is tolerated well and can be applied in addition to intensive oral care and hygiene along with the application of fluorides. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 23, 2020 Category: Cancer & Oncology Source Type: research

Implementing a  new scale for failure mode and effects analysis (FMEA) for risk analysis in a radiation oncology department
ConclusionThe introduced rating scale together with a  questionnaire survey provides merit for conducting FMEA in radiation oncology as results are comparable to the use of VRS and the process is facilitated. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 18, 2020 Category: Cancer & Oncology Source Type: research

Impact of radiation techniques on lung toxicity in patients with mediastinal Hodgkin ’s lymphoma
AbstractPurposeMediastinal radiotherapy (RT), especially when combined with bleomycin, may result in substantial pulmonary morbidity and mortality. The use of modern RT techniques like intensity-modulated radiotherapy (IMRT) is gaining interest to spare organs at risk.MethodsWe evaluated 27  patients who underwent RT for Hodgkin’s lymphoma between 2009 and 2013 at our institution. For each patient, three different treatment plans for a 30-Gy involved-field RT (IFRT) were created (anterior-posterior-posterior-anterior setup [APPA], 5‑field IMRT, and 7‑field IMRT) and analyzed concerning their inherent ...
Source: Strahlentherapie und Onkologie - September 17, 2020 Category: Cancer & Oncology Source Type: research

#Stayathome: Smart working for radiation oncologists during the corona pandemic
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 17, 2020 Category: Cancer & Oncology Source Type: research

Artificial intelligence and radiomics for radiation oncology
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 17, 2020 Category: Cancer & Oncology Source Type: research

R0 resection following chemo (radio)therapy improves survival of primary inoperable pancreatic cancer patients. Interim results of the German randomized CONKO-007 ± trial
AbstractPurposeChemotherapy with or without radiotherapy is the standard in patients with initially nonmetastatic unresectable pancreatic cancer. Additional surgery is in discussion. The CONKO-007 multicenter randomized trial examines the value of radiotherapy. Our interim analysis showed a  significant effect of surgery, which may be relevant to clinical practice.MethodsOne hundred eighty patients received induction chemotherapy (gemcitabine or FOLFIRINOX). Patients without tumor progression were randomized to either chemotherapy alone or to concurrent chemoradiotherapy. At the end of therapy, a  panel of five i...
Source: Strahlentherapie und Onkologie - September 9, 2020 Category: Cancer & Oncology Source Type: research

Measures of infection prevention and incidence of SARS-CoV-2 infections in cancer patients undergoing radiotherapy in Germany, Austria and Switzerland
ConclusionMost ROIs reported a  deep impact of SARS-CoV‑2 infections on their work routine. Modification and prioritization of treatment regimens and the application of protective measures preserved a well-functioning radiation oncology service and patient care. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 9, 2020 Category: Cancer & Oncology Source Type: research

Cone-beam computed tomography-based radiomics in prostate cancer: a  mono-institutional study
ConclusionOur results suggest the usefulness of CBCT-based radiomics for treatment definition in prostate cancer. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 31, 2020 Category: Cancer & Oncology Source Type: research

Moderately hypofractionated radiotherapy for localized prostate cancer: updated long-term outcome and toxicity analysis
ConclusionModerately hypofractionated radiotherapy using SIB treatment planning and cone beam CT image guidance resulted in high biochemical control and survival with low rates of late toxicity. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 23, 2020 Category: Cancer & Oncology Source Type: research

The role of radiomics in prostate cancer radiotherapy
Abstract“Radiomics,” as it refers to the extraction and analysis of a large number of advanced quantitative radiological features from medical images using high-throughput methods, is perfectly suited as an engine for effectively sifting through the multiple series of prostate images from before, durin g, and after radiotherapy (RT). Multiparametric (mp)MRI, planning CT, and cone beam CT (CBCT) routinely acquired throughout RT and the radiomics pipeline are developed for extraction of thousands of variables. Radiomics data are in a format that is appropriate for building descriptive and predictiv e mo...
Source: Strahlentherapie und Onkologie - August 20, 2020 Category: Cancer & Oncology Source Type: research

Belastungsintoleranz, beeintr ächtigte Organfunktionen und Mortalität bei erwachsenen Überlebenden nach Krebs im Kindesalter
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 20, 2020 Category: Cancer & Oncology Source Type: research

Randomisierte, kontrollierte Studie zur palliativen Radiotherapie von Kopf-Hals-Tumoren – Herausforderungen bleiben bestehen
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 20, 2020 Category: Cancer & Oncology Source Type: research

Low-dose radiotherapy for COVID-19 pneumonia treatment: case report, procedure, and literature review
ConclusionWhole-lung low-dose radiotherapy seems to be a  promising approach for avoiding or delaying invasive respiratory support. Delivered low doses are far from meeting toxicity ranges. On-going prospective trials will elucidate the effectiveness of this approach. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 19, 2020 Category: Cancer & Oncology Source Type: research

Cardiac serum marker alterations after intraoperative radiotherapy with low-energy x-rays in early breast cancer as an indicator of possible cardiac toxicity
ConclusionTroponin  I levels as a marker of acute cardiac toxicity did not show any significant differences in patients who received IORT during breast-conserving surgery compared to those who did not. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 18, 2020 Category: Cancer & Oncology Source Type: research

Kaugummi zur Linderung der strahleninduzierten Xerostomie – eine randomisierte Phase-III-Studie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 10, 2020 Category: Cancer & Oncology Source Type: research

Prospective evaluation of multitarget treatment of pediatric patients with helical intensity-modulated radiotherapy
ConclusionOur results showed acceptable levels of acute and late toxicities, considering the highly advanced diseases and multimodal treatment. Hence, tomotherapy is a  feasible treatment method for young patients with anatomically complex tumors or multiple targets. Especially mtRT is a promising and innovative treatment approach for pediatric sarcomas, delivering unexpectedly high survival rates for patients with multifocal Ewing sarcomas in this study, whereb y the limited number of patients should invariably be considered in the interpretation. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 2, 2020 Category: Cancer & Oncology Source Type: research

Post-neoadjuvant treatment with capecitabine and trastuzumab emtansine in breast cancer patients —sequentially, or better simultaneously?
ConclusionRegarding oncologic outcome, the influence of sequencing radiation therapy with maintenance capecitabine chemotherapy in the post-neoadjuvant setting is unclear. Synchronous administration of capecitabine is feasible, but reports on possible excess toxicities are partially conflicting. Dose reduction of capecitabine should be considered, especially if normofractionated radiotherapy is used. In terms of tolerance, hypofractionated schedules seem to be superior in terms of toxicity in concurrent settings. T ‑DM1 can safely be administered concurrently with radiotherapy. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 30, 2020 Category: Cancer & Oncology Source Type: research

The role of different lymph node staging systems in predicting prognosis and determining indications for postmastectomy radiotherapy in patients with T1-T2pN1 breast carcinoma
ConclusionIn early-stage BC patients undergoing mastectomies, LN dissections and no PMRT, we propose LNR-based multivariable models to predict OS/LRFS with superior accuracy. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 23, 2020 Category: Cancer & Oncology Source Type: research