Total body irradiation of bone marrow transplant using helical TomoTherapy with a  focus on the quality of dose contribution at junction target volumes
ConclusionSince junction-based planning was required for most TBI patients, it is essential to evaluate the quality of dose coverage in the junction for better TBI plans. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 14, 2021 Category: Cancer & Oncology Source Type: research

Correction: Ribociclib in Kombination mit endokriner Therapie verbessert Überleben von prä-/perimenopausalen Mammakarzinom-Patientinnen
Eine Correction zu dieser Publikation wurde ver öffentlicht:https://doi.org/10.1007/s00066-019-01574-y (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 14, 2021 Category: Cancer & Oncology Source Type: research

Motion-compensated FDG PET/CT for oesophageal cancer
ConclusionSUVmax of the primary oesophageal tumour and lymph nodes was comparable on 3D and motion-compensated PET/CT. The use of motion-compensated PET/CT did not improve lymph node detection. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 7, 2021 Category: Cancer & Oncology Source Type: research

Dosimetric comparison of volumetric modulated arc therapy (VMAT) and high-dose-rate brachytherapy (HDR-BT) for superficial skin irradiation with significant curvature in one or more planes
This study compares the plan quality of high-dose-rate brachytherapy (HDR-BT) and volumetric modulated arc therapy (VMAT) for superficial irradiation of large areas of skin with significant curvature in one or more planes.MethodsA total of 14 patients from two centres previously treated with either HDR-BT or VMAT were retrospectively replanned using the alternative technique. Sites included scalp and lower limbs. Identical computed tomography (CT) scans, clinical target volume (CTV) and organs at risk (OARs) and prescription were used for both techniques. Conformity, skin surface dose and OAR doses were compared.ResultsCon...
Source: Strahlentherapie und Onkologie - March 31, 2021 Category: Cancer & Oncology Source Type: research

Influence of pain duration on pain outcomes following palliative radiotherapy for painful tumors: the sooner the irradiation, the better?
AbstractPurposeThe influence of pre-radiotherapy pain duration on post-treatment outcomes was assessed.MethodsPatients that received palliative radiotherapy were analyzed in a  prospective observational study investigating curative and palliative radiotherapy. Brief Pain Inventory data were acquired at baseline and 1, 2, and 3 months after commencing irradiation. The pain response in terms of the index pain (i.e., pain caused by the irradiated tumors) was assessed using the International Consensus Endpoint. Patients were diagnosed with predominance of other pain (POP) if non-index pain of malignant or unknown ori...
Source: Strahlentherapie und Onkologie - March 30, 2021 Category: Cancer & Oncology Source Type: research

Kurzzeitstrahlentherapie mit 5  × 5 Gy gefolgt von präoperativer Chemotherapie und Resektion bei Patienten mit lokal fortgeschrittenen Rektumkarzinomen führt zu einer Verbesserung des krankheitsfreien Überlebens
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 25, 2021 Category: Cancer & Oncology Source Type: research

Aggressive Deeskalation der Strahlentherapie bei HPV-assoziierten Oropharynxkarzinomen auf der Basis der Hypoxiedynamik
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 25, 2021 Category: Cancer & Oncology Source Type: research

Das Lymph ödemrisiko von Mammakarzinompatientinnen nach Operation oder Strahlentherapie der Axilla
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 25, 2021 Category: Cancer & Oncology Source Type: research

Lebensqualit ät der Patientinnen mit DCIS nach brusterhaltender Operation und adjuvanter Strahlentherapie: konventionell fraktioniert vs. hypofraktioniert, mit und ohne Boost
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 24, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Cardiac doses of accelerated partial breast irradiation with perioperative multicatheter interstitial brachytherapy
A Correction to this paper has been published:https://doi.org/10.1007/s00066-020-01699-5 (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 23, 2021 Category: Cancer & Oncology Source Type: research

Verschlechterung der Lebensqualit ät von Patienten mit Morbus Hodgkin in den folgenden 5 Jahren nach abgeschlossener Therapie: Langzeitdaten aus den Studien HD13, HD14 und HD15
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 22, 2021 Category: Cancer & Oncology Source Type: research

Effective method to reduce the normal brain dose in single-isocenter hypofractionated stereotactic radiotherapy for multiple brain metastases
AbstractBackground and purposeIsland blocking and dose leakage problems will lead to unnecessary irradiation to normal brain tissue (NBT) in hypofractionated stereotactic radiotherapy (HSRT) for multiple brain metastases (BM) with single-isocenter volumetric modulated arc therapy (VMAT). The present study aimed at investigating whether reducing the number of metastases irradiated by each arc beam could minimize these two problems.Materials and methodsA total of 32  non-small-cell lung cancer (NSCLC) patients with multiple BM received HSRT (24–36 Gy/3 fractions) with single-isocenter VMAT, where each arc beam o...
Source: Strahlentherapie und Onkologie - March 16, 2021 Category: Cancer & Oncology Source Type: research

Chemoradiotherapy by intensity-modulated radiation therapy with simultaneous integrated boost in locally advanced or oligometastatic non-small-cell lung cancer —a two center experience
ConclusionsChemoradiotherapy using SIB-IMRT showed promising local tumor control rates and acceptable toxicity in patients with locally advanced and in part oligometastatic lung cancer. The SIB concept, resulting in a  relatively low mean lung dose, was associated with low numbers of clinically relevant pneumonitis. The overall survival appears promising in the presence of a majority of patients with UICC stage ≥IIIB disease. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 16, 2021 Category: Cancer & Oncology Source Type: research

Interstitial single fraction brachytherapy for malignant pulmonary tumours
ConclusionsInterstitial brachytherapy for pulmonary tumours is a  highly conformal therapy with minimal doses to the organs at risk. For the majority of patients, treatment can be performed without relevant complications in a single fraction with a satisfactory local control. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 16, 2021 Category: Cancer & Oncology Source Type: research

Effect of irradiation on the expression of E-cadherin and β-catenin in early and late radiation sequelae of the urinary bladder and its modulation by NF-κB inhibitor thalidomide
ConclusionUpregulation of AJ proteins is an attempt to compensate irradiation-induced impairment of urothelial barrier function. Early administration of thalidomide improves these compensatory mechanisms by inhibiting NF- κB signaling and its interfering effects. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 10, 2021 Category: Cancer & Oncology Source Type: research

Sollen fortgeschrittene Magenkarzinome zuk ünftig nur mehr laparoskopisch operiert werden?
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 9, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Prognostic impact of gross tumor volume during radical radiochemotherapy of locally advanced non-small cell lung cancer —results from the NCT03055715 multicenter cohort study of the Young DEGRO Trial Group
A Correction to this paper has been published:https://doi.org/10.1007/s00066-020-01727-4 (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 5, 2021 Category: Cancer & Oncology Source Type: research

Systemischer Effekt einer lokalen Strahlentherapie: erste klinische Evidenz
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 4, 2021 Category: Cancer & Oncology Source Type: research

Ist Aloe vera zur Pr ävention und Therapie der akuten radiogenen Proktitis geeignet?
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 4, 2021 Category: Cancer & Oncology Source Type: research

Pr äoperative Strahlentherapie von retroperitonealen Weichteilsarkomen: Ergebnisse der EORTC-STRASS-Studie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 4, 2021 Category: Cancer & Oncology Source Type: research

Cumulative dose, toxicity, and outcomes of spinal metastases re-irradiation
AbstractPurposeThe aim of this study was to identify patient-, tumor-, or treatment-related factors which may affect disease-related outcomes of re-irradiation (reRT) in patients with previously irradiated vertebral metastases.MethodsA computerized search of the literature was performed by searching for terms related to reRT and spinal metastases in MEDLINE, EMBASE, OVID, and the Cochrane database from 1995 to 2019. Studies including at least 10  patients who had received reRT at the same site of initial radiotherapy for vertebral metastases with localized external beam radiotherapy were included. To determine the poo...
Source: Strahlentherapie und Onkologie - February 26, 2021 Category: Cancer & Oncology Source Type: research

Improving dose delivery accuracy with EPID in vivo dosimetry: results from a  multicenter study
ConclusionThe results obtained with different IVD software and among centers were consistent and showed an acceptable homogeneity. EPID IVD was effective in intercepting important errors. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - February 16, 2021 Category: Cancer & Oncology Source Type: research

Vulnerabilit äten bei Radiomics: Warum die populärste Radiomics-Signatur unbemerkt das Tumorvolumen gemessen hat
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - February 3, 2021 Category: Cancer & Oncology Source Type: research

Kurative Strahlentherapie von Oligometastasen: Langzeitergebnisse der SABR-COMET-Studie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - February 2, 2021 Category: Cancer & Oncology Source Type: research

Moderate hypofractionation remains the standard of care for whole-breast radiotherapy in breast cancer: Considerations regarding FAST and FAST-Forward
This article summarizes recent data for moderate hypofractionation and results from the FAST and FAST-Forward trial on ultra-hypofractionation. Whil e the FAST trial was not powered for comparison of local recurrence rates, FAST-Forward demonstrated non-inferiority for two ultra-hypofractionated regimens in terms of local control. In both trials, the higher-dose experimental arms resulted in elevated rates of late toxicity. For the lower dose ex perimental arms of 28.5 Gy over 5 weeks and 26 Gy over 1 week, moderate or marked late effects were similar in the majority of documented items compared to the respec...
Source: Strahlentherapie und Onkologie - January 28, 2021 Category: Cancer & Oncology Source Type: research

Biochemical control after adjuvant radiation therapy for prostate cancer: a  unicentric, retrospective analysis
ConclusionPostoperative radiotherapy with an average dose of 66  Gy to the prostatic fossa following RPE provides excellent tumour control rates with acceptable side effects. Patients with a higher risk of positive lymph nodes (>  15%) according to the Roach formula show significant worse tumour control rates. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - January 27, 2021 Category: Cancer & Oncology Source Type: research

Long-term effect and prognostic factors of a  low-dose radiotherapy of painful plantar calcaneal spurs
ConclusionsLow-dose radiotherapy is a  safe and effective treatment option for patients with painful plantar calcaneal spurs. An initial aggravation of pain during or within 3 months after radiotherapy was identified as unfavorable prognostic factor for the treatment outcome. Re-irradiation of patients with an unsatisfactory pain redu ction after low-dose radiotherapy is effective and should be offered to patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - January 27, 2021 Category: Cancer & Oncology Source Type: research

COVID-19 pneumonia treated with ultra-low doses of radiotherapy (ULTRA-COVID study): a  single institution report of two cases
ConclusionPreliminary clinical and radiological results suggest a  potential benefit of treating COVID-19 pneumonia with ULTRA-COVID.ClinicalTrials.gov Identifier: NCT04394182 (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - January 27, 2021 Category: Cancer & Oncology Source Type: research

Patterns of care for prostate cancer radiotherapy —results from a survey among German-speaking radiation oncologists
ConclusionGerman-speaking radiation oncologists ’ patterns of care for patients with PC are mainly in line with the published data and treatment recommendation guidelines. However, dose prescription is highly heterogenous for RT of the prostate/prostate bed, while the dose to the pelvic LNs is mainly consistent. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - January 27, 2021 Category: Cancer & Oncology Source Type: research

Prediction of treatment response in patients with locally advanced cervical cancer using midtreatment PET/MRI during concurrent chemoradiotherapy
AbstractPurposeWe aimed to find metabolic, functional or morphological characteristics of the tumor predicting failure to achieve complete metabolic remission (CMR) by the midtreatment PET/MRI (positron emission tomography/magnetic resonance imaging) in cervical cancer patients.MethodsWe evaluated 66  patients treated between August 2015 and November 2019 who underwent pretreatment staging, subsequent midtreatment evaluation, and definitive restaging 3 months after completing the whole treatment, all using PET/MRI. The pretreatment parameters (pre-SUVmax, pre-SUVmean, pre-MTV, pre-MTV‑S, pre -TLG, pre-TLG‑S [...
Source: Strahlentherapie und Onkologie - January 25, 2021 Category: Cancer & Oncology Source Type: research

Severe skin toxicity during whole-brain radiotherapy, targeted therapy, and additional drug intake including St. John ’s wort skin oil
ConclusionSt. John ’s wort seems to be a significant radiosensitizer for photon radiotherapy and can cause severe skin toxicity even though the literature lacks data on this interaction. As an OTC, it is easily accessible and often used by oncological patients due to antidepressant and local antimicrobial and pain- relieving effects. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - January 24, 2021 Category: Cancer & Oncology Source Type: research

PSMA-PET-CT zum prim ären Staging von Patienten mit fortgeschrittenem Prostatakarzinom
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - January 15, 2021 Category: Cancer & Oncology Source Type: research

Is prone free breathing better than supine deep inspiration breath-hold for left whole-breast radiotherapy? A  dosimetric analysis
ConclusionProne compared with supine DiBH was associated with a  dosimetric gain in 62.1% of our left-sided breast cancer patients. High pendulousness and moderately large breast predicted for the gain. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - January 8, 2021 Category: Cancer & Oncology Source Type: research

Prognostic impact of gross tumor volume during radical radiochemotherapy of locally advanced non-small cell lung cancer —results from the NCT03055715 multicenter cohort study of the Young DEGRO Trial Group
ConclusionOur results indicate that independently of T  stage, the re-planning GTV during RCT is a significant and superior survival predictor compared to baseline GTV before RT. Patients with a high absolute (rather than relative) change in GTV during RT show a superior survival outcome after RCT. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - January 7, 2021 Category: Cancer & Oncology Source Type: research

PORTEC-3-Studie f ür Endometriumkarzinome mit hohem Risiko: Auswirkungen der molekularen Klassifizierung auf die Prognose und den Nutzen einer adjuvanten Therapie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - January 5, 2021 Category: Cancer & Oncology Source Type: research

Pr äoperative Radiotherapie plus Resektion vs. Operation allein bei Patienten mit primärem retroperitonealem Sarkom (EORTC-62092: STRASS): eine multizentrische, randomisierte Phase-III-Studie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - January 5, 2021 Category: Cancer & Oncology Source Type: research

Kardioonkologie: Herzdosis w ährend einer Radiotherapie im Thoraxbereich
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - January 5, 2021 Category: Cancer & Oncology Source Type: research

A  hesitated approach: primary radiotherapy for keloids—a case series
AbstractPurposeTo assess the efficacy and toxicity of hypofractionated radiotherapy (RT) alone in treatment-resistant symptomatic keloids.MethodsSix patients with a  total of 13 inoperable large keloid lesions and no response to previous treatments were admitted to our department between 2017 and 2019. All patients were examined for detailed wound localization, size, contour, and color assessment, and for objective and subjective symptoms. Response to treatmen t was graded as “complete remission” in case of full symptomatic relief and>75% decrease in lesion size, as “partial remission” in ca...
Source: Strahlentherapie und Onkologie - January 4, 2021 Category: Cancer & Oncology Source Type: research

Parotid sparing and quality of life in long-term survivors of locally advanced head and neck cancer after intensity-modulated radiation therapy
ConclusionLong-term HNC survivors show a  similar treatment-related toxicity profile independent of unilateral vs. bilateral parotid-sparing IMRT. Sparing one or both parotids had no effect on global QoL nor on the magnitude of changes in function and symptom scales over the observation period of 60 months. The financial impact of the di sease and its detrimental effect on long-term QoL pose an additional risk to unmet needs in this special patient population. These results suggest that long-term survivors need and most likely will benefit from early medical intervention and support within survivorship programs. ...
Source: Strahlentherapie und Onkologie - December 30, 2020 Category: Cancer & Oncology Source Type: research

Peer review analysis in the field of radiation oncology: results from a  web-based survey of the Young DEGRO working group
ConclusionThe scientific content of the manuscript, reputation of the journal and a  high IF determine the attractiveness for peer reviewing in the field of radiation oncology. The majority of participants prefer a double-blind peer review process and would conduct more reviews if compensation was available. Free access to journal articles, discounts for publication costs or cong ress fees, or an expense allowance were identified to increase attractiveness of the review process. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 18, 2020 Category: Cancer & Oncology Source Type: research

Correction to: Managing patient flows in radiation oncology during the COVID-19 pandemic
A Correction to this paper has been published:https://doi.org/10.1007/s00066-020-01698-6 (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 15, 2020 Category: Cancer & Oncology Source Type: research

miR-573 suppresses pancreatic cancer cell proliferation, migration, and invasion through targeting TSPAN1
ConclusionOur findings indicated that miR-573 suppresses pancreatic cancer cell proliferation, migration, and invasion through targeting TSPAN1. TSPAN1 targeted by miR-573 might be a  potential therapeutic target for clinical treatment of pancreatic cancer. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 15, 2020 Category: Cancer & Oncology Source Type: research

Impact of guideline changes on adoption of hypofractionation and breast cancer patient characteristics in the randomized controlled HYPOSIB trial
ConclusionThe use of HFseq in the standard arm increased over the course of the HYPOSIB trial and after publication of the S3 guideline update. This was primarily driven by patients treated in university hospitals. Enrolment of patients with lymph node involvement was low throughout the trial. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 15, 2020 Category: Cancer & Oncology Source Type: research

Abnehmende Morbidit ät und Letalität bei Kindern nach Behandlung einer akuten lymphoblastischen Leukämie: ein Bericht der Childhood Cancer Survivor Study
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 11, 2020 Category: Cancer & Oncology Source Type: research

Sichere Schwangerschaft nach Brustkrebstherapie von BRCA-Mutations-Tr ägerinnen?
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 11, 2020 Category: Cancer & Oncology Source Type: research

Ultrahypofractionation of localized prostate cancer
AbstractDue to its low fractionation sensitivity, also known as “alpha/beta ratio,” in relation to its surrounding organs at risk, prostate cancer is predestined for hypofractionated radiation schedules assuming an increased therapeutic ratio compared to normofractionated regimens. While moderate hypofractionation (2.2–4 Gy) has been proven to be non-inf erior to normal fractionation in several large randomized trials for localized prostate cancer, level I evidence for ultrahypofractionation (>4  Gy) was lacking until recently. An accumulating body of non-randomized evidence has recently ...
Source: Strahlentherapie und Onkologie - December 10, 2020 Category: Cancer & Oncology Source Type: research

Long-term follow-up of children with neuroblastoma receiving radiotherapy to metastatic lesions within the German Neuroblastoma Trials NB97 and NB  2004
ConclusionRT to metastases is feasible for patients with stage  4 NB. However, an impact of RT to residual metastatic sites on outcome was not found. Studies with larger cohorts or prospective trials would be desirable in order to elucidate the role of RT for metastases. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 9, 2020 Category: Cancer & Oncology Source Type: research

The risk of late effects following pediatric and adult radiotherapy regimens in Hodgkin lymphoma
ConclusionPediatric regimens selected patients with more advanced disease to radiotherapy resulting in larger target volumes and higher doses to the OARs. Target volume rather than prescribed dose impacted OAR exposure. Consequently, the estimated risk of radiation-induced late effects and corresponding LYL was increased when compared to adult regimens. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 9, 2020 Category: Cancer & Oncology Source Type: research

In reply to Afkhami Ardekani  M et al.
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 9, 2020 Category: Cancer & Oncology Source Type: research

Letter to the editor on: F.  Campostrini et al. Association between acute histopathological changes of rectal walls and late radiation proctitis following radiotherapy for prostate cancer
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 9, 2020 Category: Cancer & Oncology Source Type: research