Factors predicting intolerance to definitive conventional radiotherapy in geriatric patients
ConclusionOverall, 19.3% of the elderly patients showed treatment intolerance during conventional radiotherapy. Serum albumin level and ECOG performance score should be considered as surrogate markers for radiotherapy interruption prior to the decision regarding definite conventional radiotherapy. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 24, 2018 Category: Cancer & Oncology Source Type: research

The impact of MRI steady-state sequences as an additional assessment modality in vestibular schwannoma patients after LINAC stereotactic radiotherapy or radiosurgery
ConclusionOur data confirmed the usefulness of SSS for anatomical segmentation of VS in LINAC-SRS/SRT treatment planning and add data supporting their potential as an adjunctive FU option in VS patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 23, 2018 Category: Cancer & Oncology Source Type: research

Local recurrence of breast cancer: conventionally fractionated partial external beam re-irradiation with curative intention
AbstractPurposeTo assess the outcome of breast cancer patients with local recurrence who underwent partial external beam re-irradiation (re-RT) either as part of a  second breast-conserving therapy or following mastectomy.MethodsBetween 03/2004 and 10/2016, 83  breast cancer patients with local recurrence were treated with surgery followed by re-RT. The re-RT schedules were 45 Gy (1.8 Gy per fraction) administered either to the partial breast (n = 42) or mastectomy scar (n = 41). The patients and tumor characteristics predictive of local control, distant control, and survival (overall and br...
Source: Strahlentherapie und Onkologie - May 23, 2018 Category: Cancer & Oncology Source Type: research

An offline technique to evaluate residual motion of the diaphragm during deep inspiratory breath-hold from cone-beam CT datasets
ConclusionsThe developed method allows an offline estimation of the inspiration depth (inter- and intra-breath-hold) over time. It will be useful as a  reference for comparison to other methods of residual motion estimation, e.g., surface scanning. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 22, 2018 Category: Cancer & Oncology Source Type: research

Kein Nachweis einer reduzierten Sp ättoxizität durch Dosisreduktion im elektiven Lymphknotenbereich in der primären Radiochemotherapie von Kopf-Hals-Tumoren
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 18, 2018 Category: Cancer & Oncology Source Type: research

Abstracts DEGRO 2018
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 17, 2018 Category: Cancer & Oncology Source Type: research

Tumor volume as a  prognostic marker in p16-positive and p16-negative oropharyngeal cancer patients treated with definitive intensity-modulated radiotherapy
ConclusionpGTV may serve as an independent prognostic factor in p16-negative patients and nGTV may serve as an independent prognostic factor both in p16-positive and p16-negative patients treated with radiochemotherapy or radiotherapy using IMRT. Tumor volume may have an impact on selecting patients for de-escalation protocols in the future, both in p16-positive and p16-negative patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 17, 2018 Category: Cancer & Oncology Source Type: research

Inclusion of dosimetric data as covariates in toxicity-related radiogenomic studies
ConclusionA large proportion of studies on the correlation of genetic markers with radiotherapy-related side effects considered no dosimetric parameters. Significance of dose distribution features was found in more than half of the studies including these features, emphasizing their importance. Completeness of radiation-specific clinical data may have increased in recent years which may improve gene-toxicity association studies. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 17, 2018 Category: Cancer & Oncology Source Type: research

Early versus late prophylactic cranial irradiation in patients with extensive small cell lung cancer
ConclusionTo reduce the incidence of brain metastases, early PCI is more effective than late PCI for ED-SCLC patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 17, 2018 Category: Cancer & Oncology Source Type: research

Patterns of care analysis for head & amp; neck cancer of unknown primary site: a  survey inside the German society of radiation oncology (DEGRO)
ConclusionDiagnostics and treatment for SCCHN  CUP within the DEGRO remain heterogeneous. A prospective register trial with standard operation procedures is warranted to homogenize and possibly improve management. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 14, 2018 Category: Cancer & Oncology Source Type: research

Absch ätzung von Langzeitrisiken der modernen Strahlentherapie bei Patientinnen mit Mammakarzinom: Evidenz zu Strahlendosen an Lunge und Herz
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 8, 2018 Category: Cancer & Oncology Source Type: research

Verl ängerung des rezidivfreien und Gesamtüberlebens beim Ovarialkarzinom im Stadium III durch hypertherme intraperitoneale Chemotherapie (HIPEC)
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 8, 2018 Category: Cancer & Oncology Source Type: research

Socioeconomic status and quality of life in patients with locally advanced head and neck cancer
ConclusionAfter IMRT for LAHNC, patients with high SES report worse QoL compared to patients with middle or low SES. There is a marked improvement within the first 24  months in many domains. However, the magnitude of improvement in patients with middle or low SES is significantly smaller compared to patients with high SES. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 7, 2018 Category: Cancer & Oncology Source Type: research

Linac-based stereotactic body radiation therapy for unresectable locally advanced pancreatic cancer: risk-adapted dose prescription and image-guided delivery
ConclusionIn our experience, risk-adapted dose prescription and image-guided SBRT represents an effective treatment option for LAPC patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 25, 2018 Category: Cancer & Oncology Source Type: research

Radiation-induced carotid artery lesions
ConclusionsRadiation-induced atherosclerosis is a  different and accelerated form of atherosclerosis, which implies a more aggressive disease with a different biologic behavior. The disease is characterized by a high rate of carotid artery stenosis compared to those observed in nonirradiated control group patients. To prevent the risk of stroke , surveillance and imaging with ultrasonography should enable detection of severe stenosis. Endovascular treatment with a carotid angioplasty and stenting has been proposed as an attractive and minimally invasive alternative for some radiation-induced stenos...
Source: Strahlentherapie und Onkologie - April 20, 2018 Category: Cancer & Oncology Source Type: research

Upregulated epithelial junction expression represents a  novel parameter of the epithelial radiation response to fractionated irradiation in oral mucosa
ConclusionFractionated irradiation significantly enhanced the expression of all proteins investigated. This study revealed a  new parameter of the epithelial radiation response to fractionated irradiation. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 19, 2018 Category: Cancer & Oncology Source Type: research

Fehlender Konsens bei Behandlungskonzepten f ür makroskopische Rezidive nach radikaler Prostatektomie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 18, 2018 Category: Cancer & Oncology Source Type: research

Polyfunctionality of CD4 + T  lymphocytes is increased after chemoradiotherapy of head and neck squamous cell carcinoma
AbstractBackgroundFor head and neck squamous cell cancer (HNSCC), standard therapy consists of surgery, radiation, and/or chemotherapy. Antineoplastic immunotherapy could be an option in an adjuvant setting and is already in palliation. A  functional immune system is a prerequisite for successful immunotherapy. However, effects of the standard-of-care therapy on the patients’ immune system are not fully understood.MethodsPeripheral blood mononuclear cells (PBMC) were collected from patients with HNSCC (n = 37) and healthy controls (n = 10). PBMC were stimulated with staphylococcal enteroto...
Source: Strahlentherapie und Onkologie - April 16, 2018 Category: Cancer & Oncology Source Type: research

Systemic administration of heparin ameliorates radiation-induced oral mucositis —preclinical studies in mice
ConclusionThese data provide the first evidence for a  protective and/or mitigative effect of heparins for radiation-induced oral mucositis. Further studies are ongoing investigating the underlying mechanism. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 16, 2018 Category: Cancer & Oncology Source Type: research

32nd Annual Meeting of the European Society for Hyperthermic Oncology
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 12, 2018 Category: Cancer & Oncology Source Type: research

Spatial orientation of coronary arteries and its implication for breast and thoracic radiotherapy —proposing “coronary strip” as a new organ at risk
ConclusionsOur study provides a  measure of the radial spread of the coronary arteries, especially from the perspective of breast radiotherapy. We have proposed a new organ at risk (OAR) of coronary strip. This should provide an easy and cost-effective way to delineate the coronary vasculature in breast cancer patients undergoin g radiotherapy. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 12, 2018 Category: Cancer & Oncology Source Type: research

Unterschiedliche Letalit ät nach Operation und stereotaktischer Strahlentherapie beim nicht-kleinzelligen Lungenkarzinom im Frühstadium
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 28, 2018 Category: Cancer & Oncology Source Type: research

Eine engmaschige internetbasierte Patientennachsorge verbessert das Gesamt überleben von Patienten mit Bronchialkarzinom
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 26, 2018 Category: Cancer & Oncology Source Type: research

The impact of [ 68 Ga]PSMA I & amp;T PET/CT on radiotherapy planning in patients with prostate cancer
Conclusion[68Ga]PSMA PET/CT is superior to CT alone for lesion detection in prostate cancer, thereby significantly impacting on radiotherapy planning for primary disease, biochemical cancer relapse, and advanced disease of prostate cancer. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 23, 2018 Category: Cancer & Oncology Source Type: research

Voxel-wise correlation of functional imaging parameters in HNSCC patients receiving PET/MRI in an irradiation setup
AbstractPurposeThe purpose of this study was to demonstrate the feasibility of voxel-wise multiparametric characterization of head and neck squamous cell carcinomas (HNSCC) using hybrid multiparametric magnetic resonance imaging and  positron emission tomography with [18F]-fluorodesoxyglucose (FDG-PET/MRI) in a  radiation treatment planning setup.MethodsTen patients with locally advanced HNSCC were examined with a  combined FDG-PET/MRI in an irradiation planning setup. The multiparametric imaging protocol consisted of FDG-PET, T2-weighted transverse short tau inversion recovery sequence (STIR) and diffusion-...
Source: Strahlentherapie und Onkologie - March 21, 2018 Category: Cancer & Oncology Source Type: research

Treatment-related features improve machine learning prediction of prognosis in soft tissue sarcoma patients
ConclusionsA  machine learning-based prognostic model combining known prognostic factors with treatment- and response-related information showed high accuracy for individualized risk assessment. This model could be used for adjustments of follow-up procedures. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 20, 2018 Category: Cancer & Oncology Source Type: research

A  feasibility study on adaptive 18 F-FDG-PET-guided radiotherapy for recurrent and second primary head and neck cancer in the previously irradiated territory
ConclusionsAdaptive PET-guided reirradiation is feasible. However, due to slow accrual and treatment results that seemed inconsistent with achieving the primary endpoint, the trial was stopped early. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 19, 2018 Category: Cancer & Oncology Source Type: research

Correction to: Analysis of primary tumor metabolic volume during chemoradiotherapy in locally advanced non-small cell lung cancer
Correction to:Strahlenther Onkol2017https://doi.org/10.1007/s00066-017-1229-3Unfortunately, an incorrect reference was provided in Table  4.The corrected version of Table  4 can be found below.We apologize for any inconvenience … (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 14, 2018 Category: Cancer & Oncology Source Type: research

Cancer patients ’ wish for psychological support during outpatient radiation therapy
ConclusionPatient-reported psychosocial problems were better predictors of a wish for PO support than sociodemographic or clinical data. Stress screening should thus be implemented in clinical routine. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 12, 2018 Category: Cancer & Oncology Source Type: research

W öchentliche oder dreiwöchentliche Cisplatin-Gaben bei der kombinierten Radiochemotherapie lokal fortgeschrittener Kopf-Hals-Tumoren?
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 12, 2018 Category: Cancer & Oncology Source Type: research

Shorter treatment times reduce the impact of intra-fractional motion
AbstractPurposeTo evaluate the impact of shorter treatment times on intra-fractional motion of the prostate during external beam radiotherapy.Methods53  h of intra-fractional motion of the prostate were recorded in real-time by 4D ultrasound (4DUS) during 720 fractions in 28 patients, 14 of which whom treated with step-and-shoot intensity-modulated radiotherapy (IMRT) and 14 of whom were treated with volumetric arc therapy (VMAT).ResultsThe average VMAT fraction was recorded for 2  min 43 s and was substantially shorter than the average step-and-shoot IMRT fraction at 6 min 13 s. Average radial displace...
Source: Strahlentherapie und Onkologie - March 9, 2018 Category: Cancer & Oncology Source Type: research

Intensity-modulated radiotherapy of prostate cancer with simultaneous integrated boost after molecular imaging with 18F-choline-PET/CT
AbstractPurposeTo analyze clinical results and quality of life of patients with localized prostate cancer after irradiation of the prostate with an  18F-choline-PET/CT-based simultaneous integrated boost (SIB) in comparison to a control group without SIB.MethodsA total of 134 patients underwent intensity-modulated radiotherapy from 2007 –2010. All patients received a total dose of 76 Gy with 2 Gy fractions to the prostate; 67 patients received an additional SIB of 80 Gy. The median follow-up was 65 months. Quality of life was evaluated with the EPIC (Expanded Prostate Cancer Index Compo...
Source: Strahlentherapie und Onkologie - March 6, 2018 Category: Cancer & Oncology Source Type: research

Lokale Metastasentherapie bei oligometatasierten Karzinomen
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 5, 2018 Category: Cancer & Oncology Source Type: research

Immune modulatory effects of radiotherapy as basis for well-reasoned radioimmunotherapies
ConclusionIn order to exploit the full power of RT and thereby develop efficient radioimmunotherapies, the dose per fraction used in RT protocols, the fractionation, the quality, and the quantity of certain immunotherapies need to be qualitatively and chronologically well-matched to the individual immune status of the patient. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 2, 2018 Category: Cancer & Oncology Source Type: research

Fallserie zur SBRT bei ventrikul ärer Tachykardie zeigt beeindruckenden Therapieeffekt
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 2, 2018 Category: Cancer & Oncology Source Type: research

Nonmetastatic pancreatic cancer
ConclusionCRT with total doses>40  Gy after induction chemotherapy leads to improved OS in patients with nonmetastatic pancreatic cancer. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 1, 2018 Category: Cancer & Oncology Source Type: research

Protective effects of systemic dermatan sulfate treatment in a  preclinical model of radiation-induced oral mucositis
ConclusionDS has a  significant mucositis-ameliorating activity with pronounced effects on mucositis frequency as well as on time course parameters. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - March 1, 2018 Category: Cancer & Oncology Source Type: research

Effect of continuous positive airway pressure administration during lung stereotactic ablative radiotherapy: a  comparative planning study
In this study, we evaluated the effect of CPAP on lung volume, tumour motion amplitude and baseline shift, as well as the dosimetric impact of the strategy.MethodsTwenty patients with lung tumours referred for SABR underwent 4D-computed tomography (CT) scans with and without CPAP (CPAP/noCPAP) at two timepoints (T0/T1). First, CPAP and noCPAP scans were compared for lung volume, tumour motion amplitude, and baseline shift. Next, CPAP and noCPAP treatment plans were computed and compared for lung dose parameters (mean lung dose (MLD), lung volume receiving 20 Gy (V20Gy), 13 Gy (V13Gy), and 5 Gy (V5Gy)) and mean heart dose (...
Source: Strahlentherapie und Onkologie - February 15, 2018 Category: Cancer & Oncology Source Type: research

Occurrence of pneumonitis following radiotherapy of breast cancer – A prospective study
AbstractAimof this study is to determine the temporal resolution of therapy-induced pneumonitis, and to assess promoting factors in adjuvant treated patients with unilateral mammacarcinoma.Patients and methodsA  total of 100 post-surgery patients were recruited. The cohort was treated by 2 field radiotherapy (2FRT; breast and chest wall,N = 75), 3 field radiotherapy (3FRT; + supraclavicular lymphatic region,N = 8), or with 4 field radiotherapy (4FRT; + parasternal lymphatic region,N = 17). Ninety-one patients received various systemic treatments prior to irradiation. Foll...
Source: Strahlentherapie und Onkologie - February 15, 2018 Category: Cancer & Oncology Source Type: research

Response rates and recurrence patterns after low-dose radiotherapy with 4  Gy in patients with low-grade lymphomas
ConclusionPrimary LDRT is an effective treatment with high ORR and long-lasting remissions in a  subset of patients with low-grade lymphoma, and may therefore be a curative treatment option for patients with low tumor burden. LDRT with the CD20 antibody obinutuzumab will soon be tested in a prospective multicenter trial. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - February 15, 2018 Category: Cancer & Oncology Source Type: research

Under-reported dosimetry errors due to interplay effects during VMAT dose delivery in extreme hypofractionated stereotactic radiotherapy
ConclusionThis study is further proof of considerable influence of interplay effects on VMAT dose delivery in stereotactic radiotherapy. For selected conditions of an exemplary scenario, interplay effects and related motion-induced target underdosage primarily occurred in tumour motion pattern with increased motion variability and VMAT plan delivery using complex MLC dose modulation. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - February 15, 2018 Category: Cancer & Oncology Source Type: research

Nachruf f ür Prof. Dr. med. Dr. hc. Wilhelm Oelßner, langjähriges Ehrenmitglied der DEGRO
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - February 15, 2018 Category: Cancer & Oncology Source Type: research

Semantic imaging features predict disease progression and survival in glioblastoma multiforme patients
ConclusionsWe demonstrated a  predictive value of several qualitative imaging features for progression and survival. The performance of prognostic models was increased by combining clinical, pathological, and imaging features. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - February 13, 2018 Category: Cancer & Oncology Source Type: research

Direct dose correlation of MRI morphologic alterations of healthy liver tissue after robotic liver SBRT
ConclusionsEarly post-treatment changes in healthy liver tissue after robotic SBRT could spatially be correlated to respective isodoses. Median nominal doses of 10.1 –11.3 Gy per fraction (EQD2 79–97 Gy3) induce characteristic morphologic alterations surrounding the lesions, potentially allowing for dosimetric in-vivo accuracy assessments. Comparison to other techniques and investigations of the short- and long-term clinical impact require further research. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - February 5, 2018 Category: Cancer & Oncology Source Type: research

Kombination aus perkutaner Strahlentherapie, Brachytherapie und Androgendeprivation gleichwertige Alternative zur radikalen Prostatektomie beim Prostatakarzinom
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - February 5, 2018 Category: Cancer & Oncology Source Type: research

Komplikationen statt Überlebensvorteil und lokale Rezidivfreiheit nach früher radikaler Zystektomie bei muskelinvasivem Harnblasenkarzinom im Vergleich zur multimodalen Erhaltungstherapie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - February 2, 2018 Category: Cancer & Oncology Source Type: research

Nivolumab f ür das vorbehandelte metastasierte Analkarzinom
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - February 1, 2018 Category: Cancer & Oncology Source Type: research

Kommentar zu „T1–2 glottic cancer treated with radiotherapy and/or surgery“
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - January 31, 2018 Category: Cancer & Oncology Source Type: research

Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer
ConclusionsThere is a  considerable lack of evidence regarding the role of adjuvant radiotherapy and its individualization based on treatment response after NACT. Results of prospective randomized trials such as NSABP B‑51/RTOG 1304 and Alliance A11202 are eagerly awaited. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - January 30, 2018 Category: Cancer & Oncology Source Type: research

Use of androgen deprivation and salvage radiation therapy for patients with prostate cancer and biochemical recurrence after prostatectomy
ConclusionsADT combined with SRT appears to improve OS in patients with a  PSA level before SRT of ≥0.7 ng/mL. In patients without persistent PSA after prostatectomy and PSA levels of
Source: Strahlentherapie und Onkologie - January 30, 2018 Category: Cancer & Oncology Source Type: research