Genetische Risikofaktoren f ür ein Zweitmalignom bei Kindern nach einer ersten onkologischen Erkrankung
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 11, 2018 Category: Cancer & Oncology Source Type: research

CT-based dose recalculations in head and neck cancer radiotherapy: comparison of daily dose recalculations to less time-consuming approaches
AbstractBackgroundThe goal of this study was to investigate if daily dose recalculations are necessary or if less time-consuming approaches can be used to identify dose differences to the planned dose in patients with head and neck cancers (H&N).MethodsFor 12  H&N  patients treated with helical tomotherapy, daily dose calculations were performed retrospectively. Four different summation doses (SuDo) were calculated: DayDo (daily dose calculation), MVCTx2, MVCTx5, and MVCTx10 (dose calculations every second, fifth, and tenth fraction). Dose recalculations wer e depicted on the last contoured mega voltage CT (...
Source: Strahlentherapie und Onkologie - December 6, 2018 Category: Cancer & Oncology Source Type: research

Institutional patient accrual volume and the treatment quality of I ‑125 prostate seed implantation in a Japanese nationwide prospective cohort study
ConclusionsOur findings indicate that the institutional patient accrual volume is associated with the treatment quality of I ‑125 prostate seed implantation. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 5, 2018 Category: Cancer & Oncology Source Type: research

Palliative care in everyday practice of radiation oncologists
AbstractPurposeLittle is known about the attitudes of radiation oncologists towards palliative care, about their competences in this field, and about the collaboration with palliative care specialists. Our aim was to close this gap and understand more about the importance of an additional qualification in palliative care.MethodsMedical members of the German Society for Radiation Oncology (DEGRO) were electronically surveyed during November –December 2016.ResultsThe survey was emailed successfully to 1110 addressees, whereas a  total of 205 questionnaires were eligible for analysis (response rate 18.4%). 55 (26.8...
Source: Strahlentherapie und Onkologie - November 29, 2018 Category: Cancer & Oncology Source Type: research

Impact of androgen deprivation therapy on apparent diffusion coefficient and T2w MRI for histogram and texture analysis with respect to focal radiotherapy of prostate cancer
ConclusionsThe TF approach has the potential for quantitative image-assisted boost volume delineation in PCa patients even if they are undergoing neoadjuvant ADT. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 26, 2018 Category: Cancer & Oncology Source Type: research

Linac-based radiosurgery or fractionated stereotactic radiotherapy with flattening filter-free volumetric modulated arc therapy in elderly patients
AbstractAimThe aim of this study was to analyze the feasibility and clinical results of linear accelerator (linac-)based stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (SFRT) with flattening filter-free (FFF) volumetric modulated arc therapy (VMAT) in elderly patients affected by brain metastases (BMs).Patients and methodsPatients selected for the present analysis were ≥65 years old with a life expectancy of>3  months, a controlled or synchronous primary tumor, and
Source: Strahlentherapie und Onkologie - November 26, 2018 Category: Cancer & Oncology Source Type: research

Biliary duct stenosis after image-guided high-dose-rate interstitial brachytherapy of central and hilar liver tumors
ConclusioniBT of liver malignancies located near the hilum can cause PHC when the central bile ducts are exposed to high point doses. Given the long latency and absence of impact of iBT-induced PHC on median survival, the rate of cholestasis and complications seen in our patients appears to be acceptable. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 23, 2018 Category: Cancer & Oncology Source Type: research

A  fatal case of Fournier’s gangrene during neoadjuvant radiotherapy for rectal cancer
ConclusionsThis case highlights the occurrence of Fournier ’s gangrene as an extremely rare but life-threatening complication during neoadjuvant radiotherapy for rectal cancer which should be refreshed in the awareness of radiation oncologists and radiologists. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 23, 2018 Category: Cancer & Oncology Source Type: research

Incidence of second primary cancers after radiotherapy combined with platinum and/or cetuximab in head and neck cancer patients
AbstractPurposeThe second primary cancer (SPC) incidence after treatment with platinum-based chemotherapy and cetuximab in combination with radiotherapy has not been previously reported. Our aim was to compare SPC risk following radiotherapy in combination with these agents for the treatment of head and neck squamous cell carcinoma (HNSCC).MethodsThe charts of 296 cases treated for loco-regionally advanced HNSCC between 2009 and 2015 were retrospectively reviewed for patient, tumor, and procedural characteristics. All patients were planned to undergo radiotherapy either with platinum compounds (group: Platinum) or monoclon...
Source: Strahlentherapie und Onkologie - November 21, 2018 Category: Cancer & Oncology Source Type: research

Impact of bladder volume on acute genitourinary toxicity in intensity modulated radiotherapy for localized and locally advanced prostate cancer
ConclusionOur results support the hypothesis that a  biofeedback training for the patient is an easy-to-apply, useful, and cost-effective tool for reducing acute GU toxicity in high-dose IMRT of the prostate. Patients who are not able to reach and maintain a certain bladder volume during planning and treatment—two independent risk factors—might need special consideration. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 15, 2018 Category: Cancer & Oncology Source Type: research

Correction to: Prof.  Dr. Luther W. Brady verstorben
Correction to:Strahlenther Onkol 2018https://doi.org/10.1007/s00066-018-1353-8Leider ist uns im Nachruf auf Professor Dr. Luther  W. Brady bei der Nennung der Ehrendoktorwürden ein Fehler unterlaufen.Die korrekte Nennung der Ehrendoktorw ürden lautet folgendermaßen:Neben zwei amerikanischen … (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 14, 2018 Category: Cancer & Oncology Source Type: research

Radiotherapy of epicondylitis humeri
ConclusionRadiotherapy of epicondylitis humeri with a  linear accelerator is an effective treatment without showing side effects. All analyzed subgroups showed a good response to radiotherapy for at least 24 months. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 13, 2018 Category: Cancer & Oncology Source Type: research

Combined stereotactic body radiotherapy and trans-arterial chemoembolization as initial treatment in BCLC stage B –C hepatocellular carcinoma
ConclusionOur experience suggests that combined TACE and SBRT can be a  safe and effective initial therapy for BCLC stage B–C HCC with appropriate patient selection. Further prospective trials are warranted. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 9, 2018 Category: Cancer & Oncology Source Type: research

Additive Chemotherapie mit Cisplatin und Gemcitabin nach kurativ intendierter Radiochemotherapie verbessert das rezidivfreie Überleben von Nasopharynxkarzinompatienten mit noch nachzuweisender EBV-DNA-Last nicht
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 8, 2018 Category: Cancer & Oncology Source Type: research

Assessment of a guideline-based heart substructures delineation in left-sided breast cancer patients undergoing adjuvant radiotherapy
ConclusionResults showed low inter-observer variability of heart substructure delineation. This constitutes an external validation of the contouring atlas used, allowing a  reliable dosimetric assessment of these volumes within the SAFE-2014 trial. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 7, 2018 Category: Cancer & Oncology Source Type: research

Patient- versus physician-reported outcomes in prostate cancer patients receiving hypofractionated radiotherapy within a  randomized controlled trial
ConclusionThere is low agreement between symptoms reported by patients and physicians, with high rates of underreporting by the physician. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 7, 2018 Category: Cancer & Oncology Source Type: research

Toxicity and risk factors after combined high-dose-rate brachytherapy and external beam radiation therapy in men ≥75 years with localized prostate cancer
ConclusionHDR-BT/EBRT is a  well-tolerated treatment option for elderly men ≥75 years with a limited number of comorbidities and localized intermediate- or high-risk prostate cancer. IMRT should be favored since side effects were significantly reduced in IMRT-treated patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 2, 2018 Category: Cancer & Oncology Source Type: research

Chemoradiotherapy with and without deep regional hyperthermia for squamous cell carcinoma of the anus
ConclusionAdditional regional hyperthermia improved overall survival, local control, and colostomy rates. Its potential beneficial role has to be confirmed in a  prospective randomized setting. Therefore, the HyCAN trial has already been established by our group and is currently recruiting patients (Clinicaltrials.gov identifier: NCT02369939). (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 2, 2018 Category: Cancer & Oncology Source Type: research

Cavity volume changes after surgery of a  brain metastasis—consequences for stereotactic radiation therapy
This study sought to evaluate potential changes in the resection cavity of a brain metastasis.MethodsIn all, 57  patients treated with HFSRT after surgical resection of one brain metastasis between 2008 and 2015 in our institution were included in this study. Gross tumor volume (GTV) of the initial metastasis and the volume of the resection cavity in the post-operative, planning, and follow-up MRIs were meas ured and compared.ResultsThe mean cavity size decreased after surgery with the greatest change of −23.4% (±41.5%) occurring between post-operative MRI and planning MRI (p 
Source: Strahlentherapie und Onkologie - November 1, 2018 Category: Cancer & Oncology Source Type: research

Is low dose radiotherapy an effective treatment for Baker ’s cyst?
ConclusionRadiotherapy of knee osteoarthritis is an effective treatment that decreases the volume of a  Baker’s cyst. Most patients respond to the treatment. Whether radiotherapy is an effective treatment for Baker’s cyst without associated osteoarthritis has to be further examined. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 30, 2018 Category: Cancer & Oncology Source Type: research

Fractionated stereotactic radiation therapy for adrenal metastases: contributing to local tumor control with low toxicity
AbstractPurposeTo report on the Erlangen (UK-Er) experience with linear accelerator stereotactic body radiation therapy (LINAC SBRT) for adrenal metastasis from various primary tumors.Materials and methods33  patients were treated. Primary sites included lung (n = 19), melanoma (n = 8), colorectal (n = 2), hepatocellular (n = 1), esophageal (n = 2), and breast cancer (n = 1). 14 patients were treated palliatively, 19 patients were treated with local curative intent.Radiation treatmentTreatment planning was done based on an exhale, mid-ventilation, and ins...
Source: Strahlentherapie und Onkologie - October 29, 2018 Category: Cancer & Oncology Source Type: research

Kombinierte Immuntherapie f ür Patienten mit Hirnmetastasen eines malignen Melanoms: Deeskalation nur unter kontrollierten Bedingungen und engmaschiger Bildgebung
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 29, 2018 Category: Cancer & Oncology Source Type: research

Adjuvante Radiotherapie bei der multimodalen Behandlung resektabler Magenkarzinome – Kritik an den Schlussfolgerungen aus CRITICS?
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 29, 2018 Category: Cancer & Oncology Source Type: research

Comparison of treatment plans for a  high-field MRI-linac and a conventional linac for esophageal cancer
ConclusionApplying conventional target volume and margin concepts as well as dose-fractionation prescription reveals clinically acceptable dose distributions using hybrid MRI-linac in its current configuration compared to standard IMRT/VMAT. This represents an important prerequisite for future studies to investigate the clinical benefit of MRI-guided radiotherapy exploiting the conceptional advantages such as reduced margins, plan adaptation and biological individualization and hypofractionation. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 25, 2018 Category: Cancer & Oncology Source Type: research

SBRT planning for spinal metastasis: indications from a  large multicentric study
AbstractBackgroundThe dosimetric variability in spine stereotactic body radiation therapy (SBRT) planning was investigated in a  large number of centres to identify crowd knowledge-based solutions.MethodsTwo spinal cases were planned by 48  planners (38 centres). The required prescription dose (PD) was 3 × 10 Gy and the planning target volume (PTV) coverage request was: VPD >  90% (minimum request: VPD >  80%). The dose constraints were: planning risk volume (PRV) spinal cord: V18Gy 
Source: Strahlentherapie und Onkologie - October 23, 2018 Category: Cancer & Oncology Source Type: research

Repeated SBRT for in- and out-of-field recurrences in the liver
ConclusionsRepeated liver SBRT is feasible, without excessive liver toxicity, when there is no considerable overlapping with pre-irradiated portions of the stomach or bowel and enough time for the liver to regenerate. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 23, 2018 Category: Cancer & Oncology Source Type: research

Exposure of remote organs and associated cancer risks from tangential and multi-field breast cancer radiotherapy
ConclusionRemote organs are important for assessment of radiation-induced cancer risk. Remote doses can be reduced effectively by application of a  tangential field configuration and a linear accelerator set-up with low head scatter radiation. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 22, 2018 Category: Cancer & Oncology Source Type: research

Dosimetric and volumetric effects in clinical target volume and organs at risk during postprostatectomy radiotherapy
ConclusionWeekly CBCTs can be considered as adequate verification tools to assess the interfractional variability of the CTV and organs at risk. The proven volume changes in the urinary bladder and the rectum do not compromise the final delivered dose in the CTV. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 17, 2018 Category: Cancer & Oncology Source Type: research

Long-term endothelial dysfunction in irradiated vessels: an immunohistochemical analysis
ConclusionThere is ongoing endothelial dysfunction in terms of increased expression of pro-thrombotic and pro-inflammatory markers in irradiated arteries even years after radiotherapy. Treating this endothelial dysfunction might reduce the complication rates associated with microvascular free flap reconstructions in irradiated patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 15, 2018 Category: Cancer & Oncology Source Type: research

Penile bulb sparing in prostate cancer radiotherapy
This study aimed to assess the reduction in dose to the penile bulb (PB) achieved by MRI-based contouring following drinking and endorectal balloon (ERB) instructions.Patients and methodsA total of 17  prostate cancer patients were treated with intensity-modulated radiation therapy (IMRT) and interstitial brachytherapy (IBT). CT and MRI datasets were acquired back-to-back based on a 65 cm3 air-filled ERB and drinking instructions. After rigid co-registration of the imaging data, the CT-based planning target volume (PTV) used for treatment planning was retrospectively compared to an MRI-based adaptive PTV and th...
Source: Strahlentherapie und Onkologie - October 12, 2018 Category: Cancer & Oncology Source Type: research

Heart toxicity from breast cancer radiotherapy
AbstractBackgroundLate cardiac toxicities caused by (particularly left-sided) breast radiotherapy (RT) are now recognized as rare but relevant sequelae, which has prompted research on risk structure identification and definition of threshold doses to heart subvolumes. The aim of the present review was to critically discuss the clinical evidence on late cardiac reactions based on dose-dependent outcome reports for mean heart doses as well as doses to cardiac substructures.MethodsA  literature review was performed to examine clinical evidence on radiation-induced heart toxicities. Mean heart doses and doses to cardiac s...
Source: Strahlentherapie und Onkologie - October 11, 2018 Category: Cancer & Oncology Source Type: research

35.  Jahrestagung der Österreichischen Gesellschaft für Radioonkologie, Radiobiologie und Medizinische Radiophysik
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 9, 2018 Category: Cancer & Oncology Source Type: research

A  density assignment method for dose monitoring in head-and-neck radiotherapy
ConclusionThe uncertainty of the three-class DAM appears to be clinically non-significant (
Source: Strahlentherapie und Onkologie - October 9, 2018 Category: Cancer & Oncology Source Type: research

Long-term survival of patients after ipilimumab and hypofractionated brain radiotherapy for brain metastases of malignant melanoma: sequence matters
ConclusionsThese data suggest that the sequence of RT and immune checkpoint inhibition with IPI may be crucial for the success of combined modality treatment of melanoma brain metastases. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 8, 2018 Category: Cancer & Oncology Source Type: research

Factors predicting intolerance to definitive conventional radiotherapy in geriatric patients
ConclusionOverall, 19.3% of the elderly patients showed treatment intolerance during conventional radiotherapy. Serum albumin level and ECOG performance score should be considered as surrogate markers for radiotherapy interruption prior to the decision regarding definite conventional radiotherapy. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2018 Category: Cancer & Oncology Source Type: research

Stereotactic radiotherapy for choroidal melanomas by means of HybridArc ™
ConclusionSRT of ocular tumours by HA is highly appropriate, and HA is superior to intensity-modulated arc therapy (IMAT) concerning dose reduction in organs at risk (OARs). The novel gradient measure SADG is more informative than Paddick ’s GI. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2018 Category: Cancer & Oncology Source Type: research

Radiation-induced acute toxicities after image-guided intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for patients with spinal metastases (IRON-1 trial)
ConclusionThis is the first randomized trial to evaluate radiation-induced toxicities after IMRT versus 3DCRT in patients with vertebral metastases. This trial demonstrated an additional improvement for IMRT in terms of acute side effects, although longer follow-up is required to further ascertain other endpoints. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2018 Category: Cancer & Oncology Source Type: research

Hochrisiko-Endometriumkarzinom: Immer eine adjuvante Radiochemotherapie?
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2018 Category: Cancer & Oncology Source Type: research

Besseres Gesamt überleben durch Brachytherapie beim Endometriumkarzinom im Stadium III
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2018 Category: Cancer & Oncology Source Type: research

Complementary medicine in radiation oncology
ConclusionToday, CAM is integrated into cancer care; however, skepticism regarding its effect still exists. Evidence-based results must be generated to convince physicians of the effectiveness of CAM methods. CAM qualifications must be included in physicians ’ training to improve their understanding and counseling regarding CAM options in cancer care. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2018 Category: Cancer & Oncology Source Type: research

Radiotherapy, tumor mutational burden, and immune checkpoint inhibitors: time to do the math
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2018 Category: Cancer & Oncology Source Type: research

Die Radiotherapie des Pleuramesothelioms – Klinische Praxisleitlinie der American Society of Clinical Oncology
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2018 Category: Cancer & Oncology Source Type: research

Prof. Dr. Luther  W. Brady verstorben
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2018 Category: Cancer & Oncology Source Type: research

MRI-based high-precision irradiation in an orthotopic pancreatic tumor mouse model
ConclusionAn MRI/CT-based treatment planning for high-precision IGRT using different techniques was established in an orthotopic pancreatic tumor model. Advanced radiation techniques allow considering perfect coverage of GTV and sparing of OARs in the preclinical setting and reflect clinical treatment plans of pancreatic cancer patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2018 Category: Cancer & Oncology Source Type: research

Automatic replanning of VMAT plans for different treatment machines: A  template-based approach using constrained optimization
ConclusionsAutomatic replanning of VMAT plans for a  different treatment machine by using pre-existing constraints as a template for a reoptimization is feasible and successful in terms of equal constraints. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2018 Category: Cancer & Oncology Source Type: research

Prognostic factors in stereotactic body radiotherapy of lung metastases
AbstractPurposeThe aim of this study was to evaluate prognostic factors in patients with lung metastases who undergo lung stereotactic body radiotherapy (SBRT).Materials and methodsA total of 87  patients with 129 lung metastases who underwent SBRT between November 2004 and May 2012 were enrolled in this retrospective study. The patient collective consisted of 54 men (62.1%) and 33 women (37.9%); the median age was 65 years (range 36–88). The Karnofsky performance index was ≥70% ( median 90%) for all cases, but one (60%). Adverse effects were categorized using the CTCAE 4.0 class...
Source: Strahlentherapie und Onkologie - October 1, 2018 Category: Cancer & Oncology Source Type: research

Early versus late prophylactic cranial irradiation in patients with extensive small cell lung cancer
ConclusionTo reduce the incidence of brain metastases, early PCI is more effective than late PCI for ED-SCLC patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2018 Category: Cancer & Oncology Source Type: research

Die kapazitive Hyperthermie scheint das Schmerzansprechen bei der palliativen Bestrahlung von schmerzhaften Knochenmetastasen zu verbessern
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 27, 2018 Category: Cancer & Oncology Source Type: research

Carboplatin verbessert nicht die Wirksamkeit der adjuvanten Radiotherapie bei fortgeschrittenen kutanen Plattenepithelkarzinomen der Kopf-Hals-Region
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 27, 2018 Category: Cancer & Oncology Source Type: research

Ist Operation und anschlie ßende Radiochirurgie gleichwertig mit Operation und Ganzhirnbestrahlung erst im Rezidiv bezüglich Gesamtüberleben und intrazerebraler Tumorkontrolle bei Patienten mit 1–4 Hirnmetastasen?
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 27, 2018 Category: Cancer & Oncology Source Type: research