Neoadjuvant chemoradiotherapy for locally advanced rectal cancer with peritumoral abscesses and fistulas
ConclusionThe presence of peritumoral abscesses and fistulas in patients with locally advanced rectal cancer is not associated with increased toxicity or inferior clinical outcomes after preoperative CRT. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 25, 2021 Category: Cancer & Oncology Source Type: research

Einfluss einer adjuvanten Strahlentherapie im Vergleich zur „Early-salvage-Strahlentherapie“ auf die Letalität von Männern mit einem hohen Rezidivrisiko nach radikaler Prostatektomie wegen Prostatakarzinom
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 25, 2021 Category: Cancer & Oncology Source Type: research

Ösophaguskarzinom: Prognoseverbesserung durch neoadjuvante Radiochemotherapie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 25, 2021 Category: Cancer & Oncology Source Type: research

Computed tomography-based deep-learning prediction of induction chemotherapy treatment response in locally advanced nasopharyngeal carcinoma
ConclusionThe noninvasive deep learning method could provide efficient prediction of treatment response to IC in locally advanced NPC and might be a  practicable approach in therapeutic strategy decision-making. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 24, 2021 Category: Cancer & Oncology Source Type: research

Integration of radiation oncology teaching in medical studies by German medical faculties due to the new licensing regulations
This report is based on a  recent survey on the current state of radiation therapy teaching at university hospitals in Germany as well as the contents of the National Competence Based Learning Objectives Catalogue for Medicine 2.0 (Nationaler Kompetenzbasierter Lernzielkatalog Medizin 2.0, NKLM) and the closely related Subject Catalogue (Gegenstandskatalog, GK) of the Institute for Medical and Pharmaceutical Examination Questions (Institut f ür Medizinische und Pharmazeutische Prüfungsfragen, IMPP). The current recommendations of the German Society for Radiation Oncology (Deutsche Gesellschaft f ür Radi...
Source: Strahlentherapie und Onkologie - November 16, 2021 Category: Cancer & Oncology Source Type: research

Adjuvant brachytherapy for oral squamous cell carcinomas: a  single-center experience comparing low-dose and pulsed-dose-rate techniques
ConclusionAdjuvant BT after excision of oral cavity SCC provides satisfactory oncological outcomes along with good tolerance. In our study, PDR-BT showed similar oncological and functional results to LDR-BT in this indication. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 16, 2021 Category: Cancer & Oncology Source Type: research

Automated hybrid volumetric modulated arc therapy (HVMAT) for whole-breast irradiation with simultaneous integrated boost to lumpectomy area
AbstractPurposeTo develop an  automated treatment planning approach for whole breast irradiation with simultaneous integrated boost using an automated hybrid VMAT class solution (HVMAT).Materials and methodsTwenty-five consecutive patients with left breast cancer received 50  Gy (2 Gy/fraction) to the whole breast and an additional simultaneous 10 Gy (2.4 Gy/fraction) to the tumor cavity. Ipsilateral lung, heart, and contralateral breast were contoured as main organs-at-risk. HVMAT plans were inversely optimized by combining two open fields with a VMAT semi-ar c beam. Open fields were setup to include the...
Source: Strahlentherapie und Onkologie - November 12, 2021 Category: Cancer & Oncology Source Type: research

Die Bedeutung der pr äoperativen Immunhistochemie bei Patientinnen mit Endometriumkarzinomen – welche Parameter sind entscheidend?
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 11, 2021 Category: Cancer & Oncology Source Type: research

Prognostic factors, efficacy, and toxicity of involved-node stereotactic body radiation therapy for lymph node oligorecurrent prostate cancer
ConclusionSBRT is a  safe and effective treatment for oligorPC, with a 100% local control rate in our series. It is not possible to clearly assess the opportunity to postpone ADT prescription in patients with two or more nodal metastases. The number of secondary lesions, time-to-nadir PSA, PSA nadir value, and the ti me interval between primary treatment and SBRT were identified as prognostic factors. Future prospective randomized studies are desirable to better understand the still open questions regarding the oligorecurrent prostate cancer state. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 10, 2021 Category: Cancer & Oncology Source Type: research

Long-term remissions in patients with early relapse of diffuse large B-cell lymphoma following high-dose chemotherapy, autologous stem cell transplantation, and radiotherapy of residual disease
ConclusionSustained long-term remissions can be achieved in patients with early relapse of DLBCL following ASCT in a  second or third treatment line, particularly in patients with low- and low-intermediate-risk IPI, following radiotherapy of residual disease after ASCT. Further investigations are required to clarify which patients need an alternative therapy (potentially CAR T‑cells or allogeneic transplantati on). (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 4, 2021 Category: Cancer & Oncology Source Type: research

Neoadjuvant concurrent chemoradiotherapy with and without hyperthermia in retroperitoneal sarcomas: feasibility, efficacy, toxicity, and long-term outcome
ConclusionNeoadjuvant chemoradiotherapy with and without hyperthermia for retroperitoneal sarcomas is feasible and provided high local control of intermediate- and high-grade sarcoma. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 4, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Innovative radiation oncology Together —Precise, Personalized, Human
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 3, 2021 Category: Cancer & Oncology Source Type: research

Sweeping-beam technique with electrons for large treatment areas as total skin irradiation
ConclusionThese results show that the mean dose to total skin varies between 1.3 and 1.8  Gy. The sweeping-beam technique with electrons has a homogeneous dose distribution in connection with a short treatment time. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 2, 2021 Category: Cancer & Oncology Source Type: research

The impact of nutritional counseling on thyroid disorders in head and neck cancer patients after (chemo)radiotherapy: results from a  prospective interventional trial
AbstractObjectiveTo analyze the impact of nutritional counseling on the development of hypothyroidism after (chemo)radiotherapy in head and neck cancer patients to propose a  new normal tissue complication probability (NTCP) model.Materials and methodsAt baseline, at the end of (chemo)radiotherapy, and during follow-up, thyroid-stimulating hormone (TSH) with free thyroxin (fT3 and fT4), nutritional status, and nutrient intake were prospectively analyzed in 46  out of 220 screened patients. Patients received (chemo)radiotherapy within an intervention (individual nutritional counseling every 2 weeks during the...
Source: Strahlentherapie und Onkologie - November 1, 2021 Category: Cancer & Oncology Source Type: research

The value of brachytherapy in the age of advanced external beam radiotherapy: a  review of the literature in terms of dosimetry
AbstractBrachytherapy (BT) has long been used for successful treatment of various tumour entities, including prostate, breast and gynaecological cancer. However, particularly due to advances in modern external beam techniques such as intensity-modulated radiotherapy (IMRT), volume modulated arc therapy (VMAT) and stereotactic body radiotherapy (SBRT), there are concerns about its future. Based on a comprehensive literature review, this article aims to summarize the role of BT in cancer treatment and highlight its particular dosimetric advantages. The authors conclude that image-guided BT supported by inverse dose planning ...
Source: Strahlentherapie und Onkologie - November 1, 2021 Category: Cancer & Oncology Source Type: research

ArthroRad trial: multicentric prospective and randomized single-blinded trial on the effect of low-dose radiotherapy for painful osteoarthritis depending on the dose —results after 3 months’ follow-up
ConclusionWe found favorable pain relief and a  limited response in the functional and quality of life scores in both arms. The effect of low doses such as 0.3 Gy on pain is widely unknown. Further trials are necessary to compare a conventional dose to placebo and to further explore the effect of low doses on inflammatory disorders. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 1, 2021 Category: Cancer & Oncology Source Type: research

Die Bedeutung der Strahlentherapie im Kontext immer effektiver werdender Systemtherapien beim metastasierten NSCLC  – Hinweise aus einer Rezidivanalyse nach Immuncheckpointinhibitoren
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 26, 2021 Category: Cancer & Oncology Source Type: research

Bridging vor CAR T-Zell-Therapie  – eine neue Indikation der Strahlentherapie?
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 26, 2021 Category: Cancer & Oncology Source Type: research

Survival outcomes, hematologic complications and growth impairment after sequential chemoradiotherapy in intracranial NGGCTs: a  retrospective study
This study aimed to evaluate the clinical features, prognostic factors, and survival outcomes for patients with intracranial nongerminomatous germ cell tumors (NGGCTs), with a  particular focus on treatment toxicity for long-term survivors.MethodsIntracranial NGGCTs treated with platinum-based chemotherapy and craniospinal irradiation (CSI) in our institution were retrospectively analyzed. Hematological complications following sequential chemoradiotherapy as well as height and weight in childhood survivors were evaluated. Plasma growth hormone (GH) concentrations prior to and after radiotherapy were obtained for the c...
Source: Strahlentherapie und Onkologie - October 21, 2021 Category: Cancer & Oncology Source Type: research

Evaluation of two modalities of perioperative treatment in the management of  extremity and truncal soft tissue sarcomas: neoadjuvant concurrent chemoradiotherapy and sequential treatment
The objective of this study was to assess the efficacy and feasibility of neoadjuvant concurrent chemoradiotherapy (cCRT) in selected grade 2–3 patients with limb or trunk wall STS, and to compare this schedule to a  sequential approach combining neoadjuvant chemotherapy and adjuvant radiotherapy.MethodsWe retrospectively included patients who underwent neoadjuvant cCRT at two comprehensive cancer centers from 1992 –2016. We then compared these results to those of patients treated with preoperative chemotherapy and postoperative radiotherapy from a third comprehensive cancer center with a pr...
Source: Strahlentherapie und Onkologie - October 21, 2021 Category: Cancer & Oncology Source Type: research

Dynamics of HMBG1 (High Mobility Group Box 1) during radiochemotherapy correlate with outcome of HNSCC patients
ConclusionHMGB1 might be a  promising marker to monitor ICD in HNSCC during the course of radiochemotherapy. However, HMGB1 seems to reflect complex and diverse immunogenic responses and potential confounders. Infections and treatment-associated toxicity should be considered when interpreting the dynamics of HMGB1. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 20, 2021 Category: Cancer & Oncology Source Type: research

Head and neck tumor cells treated with hypofractionated irradiation die via apoptosis and are better taken up by M1-like macrophages
ConclusionHNSCC cells treated with hypofractionated irradiation foster phagocytosis by anti-tumorigenic M1 macrophages. The data provide the first evidence on the impact of the HPV status of HNSCC cells on the modulation of the macrophage response to irradiated tumor cells. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 19, 2021 Category: Cancer & Oncology Source Type: research

Risk stratification by anamnesis increases SARS-CoV-2 test efficiency in cancer patients
ConclusionTo the best of our knowledge, this is the first study evaluating the correlation between individual risk factors and positivity rates of SARS-CoV ‑2 tests in cancer patients. The data demonstrate that clinical and anamnestic assessment is a simple and effective measure to distinctly increase SARS-CoV‑2 test efficiency. This might enable cancer centers to adjust test strategies in asymptomatic patients, especially when test resources are scarce. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 7, 2021 Category: Cancer & Oncology Source Type: research

Indications of IMRT, PRT and CIRT for HCC from comparisons of dosimetry and normal tissue complication possibility
AbstractPurposeTo identify the indications for hepatocellular carcinoma (HCC) irradiated by intensity-modulated photon radiotherapy (IMRT), proton radiotherapy (PRT) or carbon-ion radiotherapy (CIRT) by comparing of dosimetric parameters and incidences of classic radiation-induced liver disease (RILD).MethodsIn all, 40  HCCs were divided into group A (tumors located>  1 cm away from gastrointestinal [GI] tract), and group B (tumors located
Source: Strahlentherapie und Onkologie - October 7, 2021 Category: Cancer & Oncology Source Type: research

Association between treatment-related lymphopenia and survival in glioblastoma patients following postoperative chemoradiotherapy
AbstractPurposeOur study investigated the association between treatment-related lymphopenia and overall survival (OS) in a  series of glioblastoma (GBM) patients. We also explored clinical and dosimetric predictors of lymphocytes depletion.MethodsBetween 2015 and 2019, 64  patients were treated at the same institution with postoperative chemoradiotherapy. Peripheral lymphocyte count (PLC) data and dose–volume histogram parameters were collected. Radiotherapy (RT) schedule consisted in standard total dose of 60 Gy in 30 daily fractions, with concomitant and adju vant temozolomide (TMZ). Posttreatment ...
Source: Strahlentherapie und Onkologie - October 6, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Value of PET imaging for radiation therapy
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 6, 2021 Category: Cancer & Oncology Source Type: research

Intraoperative Teilbrustbestrahlung mit Elektronen (ELIOT) vs. konventionelle Ganzbrustbestrahlung beim invasiven Mammakarzinom im fr ühen Stadium nach brusterhaltender Operation: Langzeitdaten einer kontrollierten, randomisierten Studie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2021 Category: Cancer & Oncology Source Type: research

Longer treatment time and lower radiation doses —an alternative for Graves’ ophthalmopathy treatment
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2021 Category: Cancer & Oncology Source Type: research

Practice of radiation therapy for anal cancer in Austria —a survey on behalf of the Austrian radiation oncology society gastrointestinal tumor group (ÖGRO-GIT)
ConclusionWe found a  high rate of agreement between the centers and concordance with major guidelines. PET-CT, routine HIV testing, and biopsies of suspicious LN seem underrepresented. The largest controversy regarding target volumes concerns inclusion of the common iliac nodes. Prescribed doses are generally in line with the recommendations or higher. OAR delineation, dose constraints, supportive care, and treatment of early anal cancer represent areas for further standardization. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 30, 2021 Category: Cancer & Oncology Source Type: research

Single-isocenter stereotactic non-coplanar arc treatment of 200  patients with brain metastases: multileaf collimator size and setup uncertainties
ConclusionThis study indicates that the HD-MLC is advantageous compared to the 120-MLC for sparing healthy brain tissue. When a  2-mm margin is applied, W‑noET is sufficient to ensure coverage of BM situated ≤ 3 cm of the plan isocenter, while for BM further away, W‑ET is recommended. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 15, 2021 Category: Cancer & Oncology Source Type: research

Comparison of carbon ion and photon reirradiation for recurrent glioblastoma
ConclusionIn conclusion, carbon ion treatment is a  safe and feasible treatment option for recurrent glioblastoma. Due to the retrospective nature of the study and two different dose levels for CIRT or FSRT, the improved outcome in CIRT reirradiation might be an effect of higher biological impact from carbon ions or a simple dose-escalation effect . This hypothesis needs prospective testing in larger patient cohorts. A prospective phase III randomized trial is in preparation at our center. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 14, 2021 Category: Cancer & Oncology Source Type: research

Neoadjuvante Radiochemotherapie kombiniert mit regionaler Tiefenhyperthermie beim Rektumkarzinom?
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 14, 2021 Category: Cancer & Oncology Source Type: research

Innovative radiation oncology Together  – Precise, Personalized, Human
ConclusionThe vision 2030 balances the ambition of physical, technological, and biological innovation as well as a  comprehensive, patient-centered, and collaborative approach towards radiotherapy & radiation oncology in Germany. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 13, 2021 Category: Cancer & Oncology Source Type: research

Ein neuer Standard zeichnet sich ab: PD-1-Erhaltungstherapie nach neoadjuvanter Radiochemotherapie und kurativer Resektion bei Ösophagus- und AEG-Karzinomen (CheckMate 577)
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 13, 2021 Category: Cancer & Oncology Source Type: research

Feasibility of aponeurectomy in combination with perioperative 192Ir high dose rate brachytherapy for Dupuytren ’s disease
AbstractPurposePartial aponeurectomy (PA) is a  standard procedure for Dupuytren’s contracture (DC). Here we report a novel approach using surgery combined with perioperative high dose rate (192Ir-HDR) brachytherapy.Methods and patientsFrom March 2018 until February 2020, thirteen rays of 6  patients with Dupyutren’s contractures underwent PA followed by HDR brachytherapy. After removal of fibrous tissue and mobilization of the tendons, one to three catheters per patient were placed intraoperatively. Immediately after surgery, a planning computer tomography with 3D-planning was per formed. T...
Source: Strahlentherapie und Onkologie - September 7, 2021 Category: Cancer & Oncology Source Type: research

Breast clinical target volume: HU-based glandular CTVs and ESTRO CTVs in modern and historical radiotherapy treatment planning
ConclusionHistorical wire and anatomic landmarks-based treatment planning sufficiently covers the glandular tissue and the theoretical gPTV generated for the glandular tissue. Modern CT-based CTV and PTV definition according to ESTRO results in a  larger treated volume than the historical wire-based techniques. HU-standardized glandular tissue contouring results in a significantly smaller CTV and might be an option for reducing the treatment volume and improving reproducibility of contouring between institutions. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 3, 2021 Category: Cancer & Oncology Source Type: research

Trends in radiotherapy inpatient admissions in Germany: a  population-based study over a 10-year period
ConclusionOur data give evidence to the notion that radiotherapy remains a  discipline with an important inpatient component. Respecting reimbursement measures and despite older patients with more comorbidities, radiotherapy institutions could sustain a constant number of cases with limited temporal shifts. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 3, 2021 Category: Cancer & Oncology Source Type: research

Significance of liver metastasis volume in breast cancer patients treated with stereotactic body radiotherapy
ConclusionLiver SBRT is an effective and safe treatment option for oligometastatic BC patients with excellent LC, promising survival, and limited toxicity. Patients with smaller tumors displayed better OS than their counterparts, validating the effectiveness of a  local treatment for this group. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 3, 2021 Category: Cancer & Oncology Source Type: research

Lokale Strahlentherapie der Prostata mit Samenblasenbasis allein oder mit elektiver Bestrahlung pelviner Lymphknotenstationen beim Hochrisiko-Prostatakarzinom?
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 2, 2021 Category: Cancer & Oncology Source Type: research

On the probability of lymph node negativity in pN0-staged prostate cancer —a theoretically derived rule of thumb for adjuvant needs
ConclusionWe developed a  theoretical formula for estimation of the npv in pN0-staged prostate cancer patients. It is a sine qua non to use the formula in a clinically experienced context before deciding to electively irradiate pelvic lymph nodes or to intensify adjuvant systemic treatment. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 2, 2021 Category: Cancer & Oncology Source Type: research

Optimization of a  protocol for contrast-enhanced four-dimensional computed tomography imaging of thoracic tumors using minimal contrast agent
ConclusionQualitatively acceptable enhancement on contrast-enhanced 4D-CT images of thoracic tumors can be obtained by varying the flow rate and delay time when minimal contrast agent is used. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 2, 2021 Category: Cancer & Oncology Source Type: research

Primary immunosuppressive TNI-based conditioning regimens in pediatric patients treated with haploidentical hematopoietic cell transplantation
AbstractPurposeThis retrospective analysis aims to address the toxicity and efficacy of a  modified total nodal irradiation (TNI)-based conditioning regimen before haploidentical hematopoietic cell transplantation (HCT) in pediatric patients.Materials and methodsPatient data including long-term follow-up were evaluated of 7  pediatric patients with malignant (n = 2) and non-malignant diseases (n = 5) who were treated by a primary TNI-based conditioning regimen. TNI was performed using anterior/posterior opposing fields. All patients received 7 Gy single-dose TNI combined with systemic age...
Source: Strahlentherapie und Onkologie - September 2, 2021 Category: Cancer & Oncology Source Type: research

Impact of postoperative radiotherapy on the outcomes of resected adrenocortical carcinoma —a real-world, population-based study
ConclusionPostoperative radiotherapy following resection of adrenocortical carcinoma is associated with better overall and cancer-specific survival. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 2, 2021 Category: Cancer & Oncology Source Type: research

Preclinical evaluation of PEGylated liposomal doxorubicin as an effective radiosensitizer in chemoradiotherapy for lung cancer
ConclusionsOur study provides preclinical in vitro and in vivo evidence of the effectiveness of PEGylated liposomal doxorubicin as a  radiosensitizer, supporting its potential clinical development as a component of chemoradiotherapy. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 2, 2021 Category: Cancer & Oncology Source Type: research

Stereotactic body radiotherapy of lymph node metastases under MR-guidance: First clinical results and patient-reported outcomes
We report a  subgroup analysis of a prospective observational study comprising patients with LNM. Patients received MR-guided SBRT at our MRIdian Linac (ViewRay Inc., Mountain View, CA, USA) between January 2019 and February 2020. Local control (LC), progression-free survival (PFS) and overall survival (OS) a nalysis were performed using the Kaplan–Meier method with log rank test to test for significance (p 
Source: Strahlentherapie und Onkologie - September 1, 2021 Category: Cancer & Oncology Source Type: research

Moderately hypofractionated radiotherapy as definitive treatment for localized prostate cancer: Pattern of practice in German-speaking countries
ConclusionAlthough opinions varied on the use of moderate-hypofractionation RT, the current survey reflected broad agreement on the notion that moderately hypofractionated RT could be considered a  standard treatment for localized prostate cancer in German-speaking countries. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 31, 2021 Category: Cancer & Oncology Source Type: research

Successful salvage of recurrent leptomeningeal disease in large cell neuroendocrine lung cancer with stereotactic radiotherapy
AbstractA  70-year old male with stage I large cell neuroendocrine carcinoma (LCNEC) of the lung underwent resection of a metachronous 5 cm brain metastasis and received postoperative hypofractionated stereotactic radiotherapy (hfSRT). Five sequential nodular leptomeningeal metastases up to 5.3 cm in di ameter were diagnosed on MRI within 10 months and were treated with SRT. Currently the patient has no evidence of intracranial disease 24 months after last irradiation without chemotherapy or whole brain radiotherapy. This is the first report of sustained complete remission of multiple large lepto me...
Source: Strahlentherapie und Onkologie - August 30, 2021 Category: Cancer & Oncology Source Type: research

Patterns of care analysis for salivary gland cancer: a  survey within the German Society of Radiation Oncology (DEGRO) and recommendations for daily practice
ConclusionSGC represents a  major challenge for clinicians, as reflected by the inhomogeneous survey results regarding diagnostics, RT approaches, and systemic therapy. Future prospective, multicenter clinical trials are warranted to improve and homogenize treatment of SGC and to individualize treatment according to histolog ic subtypes and risk factors. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 24, 2021 Category: Cancer & Oncology Source Type: research

Prospective validation of stringent dose constraints for prostatic stereotactic radiation monotherapy: results of a  single-arm phase II toxicity-oriented trial
AbstractPurposeThere are no safety-focused trials on stereotactic body radiotherapy (SBRT) for localized prostate cancer. This prospective 3 ‑year phase II trial used binomial law to validate the safety and efficacy of SBRT with stringent organ at risk dose constraints that nevertheless permitted high planning target volume doses.MethodsAll consecutive ≥ 70-year-old patients with localized prostate adenocarcinoma who underwent SBRT between 2014 and 2018 at the National Radiotherapy Center in Luxembourg were included. Patients with low Cancer of Prostate Risk Assessment (CAPRA) scores (0–2) and intermediat...
Source: Strahlentherapie und Onkologie - August 23, 2021 Category: Cancer & Oncology Source Type: research

Intraoperative radiotherapy with low-energy x-rays after neurosurgical resection of brain metastases —an Augsburg University Medical Center experience
ConclusionIORT with 50-kV x ‑rays is a safe and appealing way to apply LBRT after neurosurgical resection of BM, with low toxicity and excellent LC. Close MRI FU is paramount to detect distant brain failure (DBF) early. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 20, 2021 Category: Cancer & Oncology Source Type: research