Dosis-Deeskalation der adjuvanten Radiochemotherapie bei HPV-positiven Oropharynxkarzinomen: die MC1273-Phase-II-Studie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 14, 2019 Category: Cancer & Oncology Source Type: research

Role of stereotactic body radiation therapy in the treatment of liver metastases: clinical results and prognostic factors
ConclusionThis study confirms the efficacy and safety of SBRT for unresectable liver metastases. Selection of cases may improve survival and LC. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 11, 2019 Category: Cancer & Oncology Source Type: research

Low-dose total skin electron beam therapy: Quality of life improvement and clinical impact of maintenance and adjuvant treatment in patients with mycosis fungoides or Sezary syndrome
ConclusionTSEBT improved disease symptoms and significantly improved emotional domains of patients ’ quality of life in patients with MF or SS. In addition, our results indicate that maintenance or adjuvant therapy after TSEBT may improve the PFS. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 7, 2019 Category: Cancer & Oncology Source Type: research

Monitoring skin dose changes during image-guided helical tomotherapy for head and neck cancer patients
ConclusionAbout half of the patients treated with SIB with HT for HNC experienced a  skin-sparing effect during therapy; only 6% experienced an increase. Our findings do not support skin-sparing ART, while suggesting the introduction of improved skin-sparing planning techniques. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 4, 2019 Category: Cancer & Oncology Source Type: research

Bevacizumab as a  treatment option for radiation necrosis after cranial radiation therapy: a retrospective monocentric analysis
ConclusionBEV might be an effective and safe therapeutic option for patients with radiation necrosis as a  complication after cranial radiation therapy. Patients seem to benefit from this treatment by improving symptomatically or through reduction of dexamethasone. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 4, 2019 Category: Cancer & Oncology Source Type: research

Role of upper abdominal reirradiation for gastrointestinal malignancies: a  systematic review of cumulative dose, toxicity, and outcomes on behalf of the Re-Irradiation Working Group of the Italian Association of Radiotherapy and Clinical Oncology (AIRO)
ConclusionDue to limited evidence as a  result of the retrospective design of the majority of the studies, our review suggests that upper abdominal Re‑I is effective in terms of local control and palliation, with a moderate rate of severe toxicities. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 4, 2019 Category: Cancer & Oncology Source Type: research

Addition of chemotherapy to hyperfractionated radiotherapy in advanced head and neck cancer —a meta-analysis
AbstractBackgroundAdding concurrent chemotherapy (CTx) to definitive radiation therapy (RT) in patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) improves overall survival. A  comparable effect has been reported for hyperfractionated radiotherapy (HFX-RT) alone. Adding concurrent CTx to HFX-RT has been investigated in multiple trials, yet an evident effect on oncological outcomes and toxicity profile has not been established to date. Thus, the aim of the current study w as to perform a meta-analysis on the clinical outcome and toxicity of the addition of CTx to HFX-RT.Patients and met...
Source: Strahlentherapie und Onkologie - October 4, 2019 Category: Cancer & Oncology Source Type: research

Image-based lung functional radiotherapy planning for non-small cell lung cancer
ConclusionThe incorporation of functional imaging for radiotherapy planning in non-small cell lung cancer is feasible and appears to be beneficial in preserving a  functional lung in non-small cell lung cancer. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 2, 2019 Category: Cancer & Oncology Source Type: research

Tumor regression during radiotherapy for non-small cell lung cancer patients using cone-beam computed tomography images
AbstractPurposePrevious literature has reported contradicting results regarding the relationship between tumor volume changes during radiotherapy treatment for non-small cell lung cancer (NSCLC) patients and locoregional recurrence-free rate or overall survival. The aim of this study is to validate the results from a  previous study by using a different volume extraction procedure and evaluating an external validation dataset.MethodsFor two datasets of 94 and 141 NSCLC patients, gross tumor volumes were determined manually to investigate the relationship between tumor volume regression and locoregional control us...
Source: Strahlentherapie und Onkologie - September 26, 2019 Category: Cancer & Oncology Source Type: research

Recurrence pattern of stereotactic body radiotherapy in oligometastatic prostate cancer: a  multi-institutional analysis
ConclusionSBRT is an effective and well-tolerated treatment option in the management of lymph node metastases from PCa. Prospective trials are necessary to better select patients who benefit most from this ablative focal treatment and better define the recurrence patterns. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 26, 2019 Category: Cancer & Oncology Source Type: research

Radiotherapy in lymphoepithelioma-like carcinoma of the skin: review of the literature and report of a  recurrent and metastatic case
We present the case of an 80-year-old male with a tumor primarily located on the lower eyelid, with two regional recurrences and cervical lymph node sprea d after surgery, treated with concurrent chemoradiation. According to the available data, this is the first case of lymph node spread from an eyelid location and the first nodal recurrence after surgery. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 9, 2019 Category: Cancer & Oncology Source Type: research

Validation and optimization of a  web-based nomogram for predicting survival of patients with newly diagnosed glioblastoma
ConclusionAn updated and validated nomogram incorporating the contemporary parameters can estimate individual survival outcomes in patients with glioblastoma with better accuracy. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 5, 2019 Category: Cancer & Oncology Source Type: research

Dosimetric comparison of inverse optimisation methods versus forward optimisation in HDR brachytherapy of breast, cervical and prostate cancer
AbstractObjectiveDosimetric comparison of HIPO (hybrid inverse planning optimisation) and IPSA (inverse planning simulated annealing) inverse and forward optimisation (FO) methods in brachytherapy (BT) of breast, cervical and prostate cancer.MethodsAt our institute 38  breast, 47 cervical and 50 prostate cancer patients treated with image-guided interstitial high-dose-rate BT were selected. Treatment plans were created using HIPO and IPSA inverse optimisation methods as well as FO. The dose–volume parameters of different treatment plans were compared with Fr iedman ANOVA and the LSD post-hoc test.Resul...
Source: Strahlentherapie und Onkologie - September 3, 2019 Category: Cancer & Oncology Source Type: research

Sicherheitsabstand von 2  cm ist bei Exzision von Hautmelanomen dicker als 2 mm ausreichend
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 28, 2019 Category: Cancer & Oncology Source Type: research

Radiotherapy for painful benign skeletal disorders
AbstractPurposeThe aim of this retrospective clinical quality assessment was to evaluate the efficacy of low-dose radiotherapy (RT) for painful benign skeletal disorders.MethodsPatients with different painful benign skeletal disorders (arthrosis and enthesopathies) were recruited for this retrospective clinical quality assessment between January 2014 and December 2015. RT was applied with a  linear accelerator. Single doses of 0.5 Gy (total dose 3.0–5.0 Gy) were used. Pain was measured before and immediately after RT (early response) by a 10-point visual analogue scale (VAS). We defined a VAS score...
Source: Strahlentherapie und Onkologie - August 27, 2019 Category: Cancer & Oncology Source Type: research

Radiotherapy after skin-sparing mastectomy with immediate breast reconstruction in intermediate-risk breast cancer
ConclusionsFor intermediate-risk as well as early stage high-risk BC patients, the DEGRO Breast Cancer Expert Panel recommends the use of PMRT following SSME and NSME when a  10-year locoregional recurrence risk is likely to be greater than 10%, as estimated by clinical and biological risk factors. Subvolume-only radiation is discouraged outside of trials. The impact of adequate systemic treatment and the value of radiotherapy on optimal locoregional tumor control, wit h the goal of less than 5% LRR at 10-years follow-up, has to be verified in prospective trials. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 26, 2019 Category: Cancer & Oncology Source Type: research

Radikale Prostatektomie oder „Watchful Waiting“ beim frühen Prostatakarzinom?
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 21, 2019 Category: Cancer & Oncology Source Type: research

Zweitmalignomrisiko nach Behandlung von lokal begrenzten Prostatakarzinomen mit Kohlenstoffionen m öglicherweise niedriger als nach Photonenbestrahlung
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 16, 2019 Category: Cancer & Oncology Source Type: research

Quality of life in patients with limited (1 –3) brain metastases undergoing stereotactic or whole brain radiotherapy
AbstractPurposePublished results of quality of life (QoL) studies mostly concern whole brain radiotherapy for limited or multiple brain metastases. This prospective multicentre study was designed to compare the QoL of patients with limited (1 –3) brain metastases treated with either whole brain (WBRT) or stereotactic radiotherapy (SRT).MethodsFrom 01/2007 –03/2011, 90 limited brain metastases patients who were previously untreated (n = 77) or had undergone primary surgery (n = 13) were recruited at 14 centres in Germany and Austria. QoL was measured with the EORTC-QLQ-C15-PAL and BN2...
Source: Strahlentherapie und Onkologie - August 15, 2019 Category: Cancer & Oncology Source Type: research

BRAF-mutierte metastasierte Melanome: Erste Daten zur langfristigen Wirksamkeit zielgerichteter Therapien
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 15, 2019 Category: Cancer & Oncology Source Type: research

Stereotaktisch ablative Bestrahlung als Standardtechnik beim NSCLC im Stadium  I bestätigt
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 13, 2019 Category: Cancer & Oncology Source Type: research

Relevanz stereotaktischer ablativer Strahlentherapie bei systemisch metastasierten Patienten
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 13, 2019 Category: Cancer & Oncology Source Type: research

Radiotherapy of patients with cardiac implantable electronic devices according to the DEGRO/DGK guideline —is the risk of relevant errors overestimated?
ConclusionErrors of CIEDs during RT are rare events. The approach according to the DEGRO/DGK guideline is safe, but also consumes resources. In our cohort it was not compulsory to relocate any CIED. Clinically relevant events are uncommon, so it remains debatable which procedure is necessary. Daily controls could be avoided in some selected cases without compromising patient safety. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 9, 2019 Category: Cancer & Oncology Source Type: research

Twelve-year results of LINAC-based radiosurgery for vestibular schwannomas
ConclusionLC and hearing preservation after SRS were excellent. Toxicity proved acceptable. Although the median administered dose (16.5  Gy) was rather high, the only factor which significantly influenced late toxicity was Koos tumor grade III–IV. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 5, 2019 Category: Cancer & Oncology Source Type: research

An evaluation of the effect of bortezomib on radiation-induced urinary bladder dysfunction
ConclusionTwo separate waves of acute radiation-induced urinary bladder dysfunction have distinct mechanisms that need further biological studies. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 30, 2019 Category: Cancer & Oncology Source Type: research

Outcome and management of rare high-grade “salivary” adenocarcinoma: the important role of adjuvant (chemo)radiotherapy
ConclusionHigh-grade ASG is considered to have an unfavorable prognosis. Adjuvant (C)RT reduces the rate of locoregional recurrences. Distant metastases are common, and an advanced T  stage has increased prognostic value for development of early distant lesions. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 26, 2019 Category: Cancer & Oncology Source Type: research

Prospective evaluation of CT-guided HDR brachytherapy as a  local ablative treatment for renal masses: a single-arm pilot trial
ConclusionHDR-BT is a  feasible and safe technique for the local ablation of renal masses. A phase II study is recruiting to evaluate the efficacy of this novel local ablative treatment in a larger study population. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 25, 2019 Category: Cancer & Oncology Source Type: research

Re-irradiation for osteoarthritis —retrospective analysis of 217 joints
ConclusionRe-irradiation of osteoarthritis is an effective and safe treatment. All subgroups showed a  good response to re-irradiation for at least 24 months. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 25, 2019 Category: Cancer & Oncology Source Type: research

Results of a  multicenter intensity modulated radiation therapy treatment planning comparison study for a sample prostate cancer case
ConclusionDifferent medical physicists or dosimetrists, photon energies, treatment planning systems, and treatment machines have an impact on the resulting dose distribution. However, the differences only become apparent when comparing DVH, analysing dose values, comparing CI, HI, GI, as well as reviewing the dose distribution in every single plane. A  new score was introduced to identify treatment plans that simultaneously deliver a low dose to all OAR. Such inter- and intra-institutional comparison studies are needed to explore different treatment planning strategies; however, there is still no automatic soluti...
Source: Strahlentherapie und Onkologie - July 24, 2019 Category: Cancer & Oncology Source Type: research

Impact of surface-guided positioning on the use of portal imaging and initial set-up duration in breast cancer patients
AbstractObjectiveThe impact of optical surface guidance on the use of portal imaging and the initial set-up duration in patients receiving postoperative radiotherapy of the breast or chest wall was investigated.Material and methodsA  retrospective analysis was performed including breast cancer patients who received postoperative radiotherapy between January 2016 and December 2016. One group of patients received treatment before the optical surface scanner was installed (no-OSS) and the other group was positioned using the addi tional information derived by the optical surface scanner (OSS). The duration of the initial...
Source: Strahlentherapie und Onkologie - July 22, 2019 Category: Cancer & Oncology Source Type: research

Heart-sparing radiotherapy techniques in breast cancer patients: a  recommendation of the breast cancer expert panel of the German society of radiation oncology (DEGRO)
ConclusionBased on the available findings, the DEGRO breast cancer expert panel recommends the use of DIBH as the best heart-sparing technique. Nonetheless, depending on the treatment volume and localization, other techniques may be employed or combined with DIBH when appropriate. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 18, 2019 Category: Cancer & Oncology Source Type: research

Successful integration of radiation oncology in preclinical medical education
ConclusionThe present evaluation demonstrates the feasibility of introducing RO in the preclinical part of medical education. The course concept shows excellent results in evaluation and may help in broadening RO knowledge and in recruiting new doctoral candidates and residents. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 15, 2019 Category: Cancer & Oncology Source Type: research

Late side effects of 3T MRI-guided 3D high-dose rate brachytherapy of cervical cancer
ConclusionThe use of 3T MRI-guided BT leads to achievement of high rates of local control with limited late morbidity as demonstrated in this series of patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 15, 2019 Category: Cancer & Oncology Source Type: research

Re-irradiation for humeral epicondylitis
ConclusionRe-irradiation of humeral epicondylitis is an effective and safe treatment. All subgroups showed a  good response to re-irradiation for at least 24 months. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 15, 2019 Category: Cancer & Oncology Source Type: research

Pulmonary function changes following helical tomotherapy in patients with inoperable, locally advanced non-small cell lung cancer
AbstractPurposeTo evaluate alterations in pulmonary function indices after helical tomotherapy and explore potential associations with biologically corrected dosimetric parameters.Patients and methodsIn 64  patients with inoperable locally advanced non-small cell lung cancer, pulmonary function tests before and within 6 months after radiotherapy were evaluated retrospectively. In the case of concurrent chemotherapy a total dose of 67.2 Gy was delivered, otherwise 70.5 Gy was provided. In 44 pa tients, late pulmonary function changes (≥6 months after radiotherapy) could also be assessed.Resul...
Source: Strahlentherapie und Onkologie - July 12, 2019 Category: Cancer & Oncology Source Type: research

Use of psychosocial services by lung cancer survivors in Germany
Conclusions/implicationsThe high proportion of psychosocial care users among lung cancer survivors in Germany indicates that patients are interested in using it and that an unmet need exists. The creation of a  broad spectrum of easily accessible services with high quality is important to enable and facilitate use. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 10, 2019 Category: Cancer & Oncology Source Type: research

Dose escalation in radiotherapy for incomplete transarterial chemoembolization of hepatocellular carcinoma
This study evaluated retrospective data of 323 HCC patients who received radiotherapy after incomplete TACE from 2001 –2016. Radiation dose in biologically effective dose (BED) (α/β = 10) was categorized as
Source: Strahlentherapie und Onkologie - July 8, 2019 Category: Cancer & Oncology Source Type: research

Definitive radiotherapy vs. postoperative radiotherapy for lower gingival carcinomas of the mandible
ConclusionsDefinitive and postoperative RT have similar treatment outcomes for patients with lower gingiva carcinomas of the lower jaw. The most common acute complications (grade ≥3) were dermatitis, oral mucositis, xerostomia and loss of taste. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 2, 2019 Category: Cancer & Oncology Source Type: research

Antioxidantien und Selen geh ören nicht in einen Topf – Bewertung der Supplementierung während Chemo- oder Strahlentherapie bei Brustkrebs
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 1, 2019 Category: Cancer & Oncology Source Type: research

Pembrolizumab ist effektiver und besser vertr äglich als Methotrexat, Docetaxel oder Cetuximab bei rezidivierten oder metastasierten HNO-Karzinomen (KEYNOTE-040)
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 27, 2019 Category: Cancer & Oncology Source Type: research

Lomustin und Temozolomid in Kombination mit Bestrahlung
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 26, 2019 Category: Cancer & Oncology Source Type: research

Stability and survival analysis of elderly patients with osteolytic spinal bone metastases after palliative radiotherapy
ConclusionsPrognostic factors influencing overall survival such as performance status and histology should guide the choice for palliative RT for SBM. Strongly hypofractionated RT regimes may be advisable for most elderly patients considering the overall poor prognosis in order to reduce hospitalization times. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 25, 2019 Category: Cancer & Oncology Source Type: research

Predicting survival and local control after radiochemotherapy in locally advanced head and neck cancer by means of computed tomography based radiomics
ConclusionCT-based radiomic signatures that correlate with survival and control after RCT were identified and allow low- and high-risk groups of patients to be identified. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 20, 2019 Category: Cancer & Oncology Source Type: research

PET/MRI-guided GTV delineation during radiotherapy planning in patients with squamous cell carcinoma of the tongue
ConclusionCombination of PET/MRI provides more information during target tumor mass delineation in radiotherapy planning of patients with SCC of the tongue than other standard imaging methods. The most frequently matching threshold value was 30% of SUVmax for primary tumor delineation and 30 –40% of SUVmax for nGTV determination. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - June 18, 2019 Category: Cancer & Oncology Source Type: research

Prognostic factors in patients with T1 glottic cancer treated with radiotherapy
AbstractPurposePresentation of long-term results of radiation treatment in patients with T1 glottic cancer and evaluation of prognostic factors.MethodsWe performed a  retrospective analysis in a group of 569 patients with T1 squamous cell glottic carcinoma treated with radiotherapy at the Center of Oncology in Cracow between 1977 and 2007. In all, 503 (88%) patients presented with T1a stage disease and 66 (12%) with T1b. Anterior commissure infiltration was pr esent in 179 (31%) patients. Average hemoglobin level prior to therapy was 13.9 g/dl. Using the body mass index (BMI), 114 (20%) patients were underweigh...
Source: Strahlentherapie und Onkologie - June 18, 2019 Category: Cancer & Oncology Source Type: research

Postoperative radiotherapy in primary resectable desmoid tumors of the neck: a  case–control study
AbstractPurposeDesmoid tumors (DTs) are rare soft tissue tumors, which frequently recur after surgery. The optimal treatment approach is still controversial due to lack of randomized data. The purpose of the study was to review a  relative large series of DTs of the neck with emphasis on the value of postoperative radiotherapy (RT).MethodsA  total of 68 patients with DTs of the neck region with or without postoperative RT between 1/2008 and 12/2017 were included. They were individually matched for factors including age, gender, tumor size and margin status with a cohort of patients who underwent operati...
Source: Strahlentherapie und Onkologie - June 6, 2019 Category: Cancer & Oncology Source Type: research

Detectability and structural stability of a  liquid fiducial marker in fresh ex vivo pancreas tumour resection specimens on CT and 3T MRI
ConclusionsThe liquid fiducial marker injected inex vivo pancreatic resection specimen was visible as hyperintensity on kV X ‑ray and CT and as hypointensity on MRI. The marker’s size was stable in formaldehyde. A marker volume of ≥50 µL is recommended in clinically used MRI sequences.In vivo injection is expected to improve the markers sphericity due to persisting metabolism and thereby enhance detectability on MRI. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 29, 2019 Category: Cancer & Oncology Source Type: research

Treatment outcomes of prostate cancer patients with Gleason score  8–10 treated with definitive radiotherapy
ConclusionsOur results validated the fact that oncologic outcomes after radical EBRT significantly differ in men with GS  8 versus those with GS 9–10 prostate cancer. We found that EBRT dose was important predictive factor regardless of ADT period. Patients receiving ‘non-optimal treatment’ (RT doses
Source: Strahlentherapie und Onkologie - May 29, 2019 Category: Cancer & Oncology Source Type: research

Risk-adapted moderate hypofractionation of prostate cancer
ConclusionRisk-adapted moderate hypofractionation is associated with low GI/GU toxicity. Given the higher rate of pelvic metastases in HR patients, slightly higher transient acute reactions should be outweighed by possible oncological benefits. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 28, 2019 Category: Cancer & Oncology Source Type: research

Radiogenomics in head and neck cancer: correlation of radiomic heterogeneity and somatic mutations in TP53, FAT1 and KMT2D
ConclusionThe landscape of somatic variants in our cohort is well in line with previous reports. An association of somatic mutations inFAT1 with reduced radiomic tumour heterogeneity could potentially elucidate the previously described favourable outcomes of these patients. Larger studies are needed to validate this exploratory data in the future. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - May 23, 2019 Category: Cancer & Oncology Source Type: research