Radiation therapy for cancer is potentially associated with reduced growth of concomitant abdominal aortic aneurysm
ConclusionIn this study, both infield and outfield radiation exposure were associated with reduced AAA growth. This finding warrants further investigation, both in a larger scale clinical cohort and on a molecular level. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 7, 2023 Category: Cancer & Oncology Source Type: research
Chronic inflammatory effects of in vivo irradiation of the murine heart on endothelial cells mimic mechanisms involved in atherosclerosis
ConclusionThe long-lasting upregulation of prominent inflammatory markers on primary heart and lung ECs suggests that local heart irradiation induces chronic inflammation in the microvasculature of the heart and partially irradiated lung that leads to cardiac injury which might be related to altered lipid metabolism in the heart. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 2, 2023 Category: Cancer & Oncology Source Type: research
Comprehensive geriatric assessment predicts radiation-induced acute toxicity in prostate cancer patients
ConclusionGeriatric conditions seem to be predictive of the development of high-grade radiation-induced toxicity in prostate cancer patients treated with definitive radiotherapy. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 2, 2023 Category: Cancer & Oncology Source Type: research
Use of immobilisation bra for daily setup of patients with pendulous breasts undergoing radiotherapy
ConclusionOur study demonstrated the feasibility of using a customised bra which provided optimal setup reproducibility while maintaining minimal skin toxicity and patient comfort, especially the value-added modesty felt among Asian women during their breast cancer radiotherapy. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 2, 2023 Category: Cancer & Oncology Source Type: research
Therapieentscheidungen beim hepatozellul ären Karzinom: Erkenntnisse aus der TRENDY-Studie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 31, 2023 Category: Cancer & Oncology Source Type: research
Long-term survival in patients with brain metastases —clinical characterization of a rare scenario
ConclusionIn this monocentric setting reflecting daily pattern of care, LTS with BM is heterogeneous and difficult to predict. Effective local treatment and modern systemic therapies often appear crucial for LTS. The impact of concomitant diseases and frailty is not clear. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 30, 2023 Category: Cancer & Oncology Source Type: research
Current situation in radiation oncology residency —Results of a national survey performed by the working group Young DEGRO of the German Society of Radiation Oncology
ConclusionThe study provides suggestions for improving RO medical training in Germany: further development of accompanying education and training programs in cooperation with professional associations, e.g., the DEGRO, structured feedback, and supervision. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 29, 2023 Category: Cancer & Oncology Source Type: research
Stereotaktische Radiotherapie plus Nivolumab bei NSCLC
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 29, 2023 Category: Cancer & Oncology Source Type: research
Whole-pelvic irradiation with boost to involved nodes and prostate in node-positive prostate cancer —long-term data from the prospective PLATIN-2 trial
ConclusionDefinitive radiation to the lymphatic drainage with SIB to the involved nodes and prostate is a safe and effective treatment approach for patients with treatment-naïve, node-positive prostate cancer with excellent infield tumor control rates and tolerable toxicity. Location rather than number of involved nodes is a major risk factor for progression. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 28, 2023 Category: Cancer & Oncology Source Type: research
Influence of demographic change on the demand for radiotherapy using forecasted predictions for prostate cancer in Germany
ConclusionWe observe an age-associated increase in primary cases of PC. This is likely to result in an increased demand for RT. The exact demand cannot be predicted. However, trends can be estimated to plan for the demand. This, though, requires a good database from cancer registries. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 28, 2023 Category: Cancer & Oncology Source Type: research
Noninvasive inter- and intrafractional motion control in ultrahypofractionated radiation therapy of prostate cancer using RayPilot HypoCath ™—a substitute for gold fiducial-based IGRT?
Conclusionthe HypoCath system allows highly accurate and robust intrafractional motion monitoring. In conjunction with cone beam CT (CBCT) for initial patient setup, it could be used as a standalone image-guided radiation therapy (IGRT) system. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 25, 2023 Category: Cancer & Oncology Source Type: research
DNA as the main target in radiotherapy —a historical overview from first isolation to anti-tumour immune response
AbstractDNA damage is one of the foremost mechanisms of irradiation at the biological level. After the first isolation of DNA by Friedrich Miescher in the 19th century, the structure of DNA was described by Watson and Crick. Several Nobel Prizes have been awarded for DNA-related discoveries. This review aims to describe the historical perspective of DNA in radiation biology. Over the decades, DNA damage has been identified and quantified after irradiation. Depending on the type of sensing, different proteins are involved in sensing DNA damage and repairing the damage, if possible. For double-strand breaks, the main repair ...
Source: Strahlentherapie und Onkologie - August 24, 2023 Category: Cancer & Oncology Source Type: research
Novel in-house knowledge-based automated planning system for lung cancer treated with intensity-modulated radiotherapy
ConclusionsOur results showed that αDiar was an effective tool to improve planning quality. Over half of the patients’ plans could be designed automatically. For the remaining patients, although the automatically designed plans did not fully meet the clinical requirements, their quality was also better than that of manual plans. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 21, 2023 Category: Cancer & Oncology Source Type: research
Abwarten oder Radiochirurgie bei asymptomatischen Vestibularisschwannomen
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 21, 2023 Category: Cancer & Oncology Source Type: research
Major complications after intraoperative radiotherapy with low-energy x-rays in early breast cancer
ConclusionIORT is an efficient and safe treatment method as< 2.5% of all IORT patients experienced major local complications. However, it seems to pose the risk of causing severe local complications that may require lengthy and burdensome treatment. Thorough preoperative counseling, implementation of recommended intraoperative precautions, and high vigilan ce for first symptoms of complications during follow-up appointments are necessary measures. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - August 17, 2023 Category: Cancer & Oncology Source Type: research
