Quality requirements for MRI simulation in cranial stereotactic radiotherapy: a guideline from the German Taskforce “Imaging in Stereotactic Radiotherapy”
AbstractAccurate Magnetic Resonance Imaging (MRI) simulation is fundamental for high-precision stereotactic radiosurgery and fractionated stereotactic radiotherapy, collectively referred to as stereotactic radiotherapy (SRT), to deliver doses of high biological effectiveness to well-defined cranial targets. Multiple MRI hardware related factors as well as scanner configuration and sequence protocol parameters can affect the imaging accuracy and need to be optimized for the special purpose of radiotherapy treatment planning. MRI simulation for SRT is possible for different organizational environments including patient refer...
Source: Strahlentherapie und Onkologie - January 2, 2024 Category: Cancer & Oncology Source Type: research
Investigating the impact of breast positioning control on physical treatment parameters in multi-catheter breast brachytherapy
ConclusionBreast positioning control improved geometric and dosimetric implant stability for individual patients, and thus enhanced physical plan validity in these cases. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - January 1, 2024 Category: Cancer & Oncology Source Type: research
Stereotactic body radiotherapy (SBRT) re-irradiation for local failures following radical prostatectomy and post-operative radiotherapy
ConclusionsManageable toxicity profile and satisfactory biochemical response suggest that SBRT in patients with local recurrence following RP and postoperative RT might be a salvage option for selected patients. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 29, 2023 Category: Cancer & Oncology Source Type: research
Is a total dose of 54 Gy with radiochemotherapy sufficient for treatment of intermediate-risk volumes in nasopharyngeal cancer?
ConclusionThese retrospective data suggest that a dose reduction may be possible for intermediate-risk volumes, especially for the primary site. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 28, 2023 Category: Cancer & Oncology Source Type: research
Can interventional radiotherapy (brachytherapy) be an alternative to surgery in early-stage oral cavity cancer? A systematic review
ConclusionIn conclusion, our review suggests that BT is effective in the treatment of early-stage OCC, particularly for T1N0 of the lip, mobile tongue, and buccal mucosa cancers, with good functional and toxicity profiles. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 18, 2023 Category: Cancer & Oncology Source Type: research
Stereotactic body radiotherapy with volumetric intensity-modulated arc therapy and flattening filter-free beams: dosimetric considerations
ConclusionWe found that FFF beams together with VMAT represent an excellent combination for SBRT of lung or liver lesions with shortest BOT for 10 MV-FFF but significant dose savings for 6 MV-FFF in lung lesions. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 13, 2023 Category: Cancer & Oncology Source Type: research
Stereotactic radiotherapy in the management of oligometastatic and recurrent head and neck cancer: a single-center experience
ConclusionStereotactic radiotherapy demonstrated favorable outcomes in patients with OMD/R-HNC with limited toxicities. Further studies are warranted to validate these findings and optimize treatment strategies for this patient population. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 8, 2023 Category: Cancer & Oncology Source Type: research
Survey in radiation oncology departments in Germany, Austria, and Switzerland: state of digitalization by 2023
ConclusionTo the best of our knowledge, this survey is the first of its kind conducted in German-speaking radiation oncology departments within the medical field. The findings suggest that there is a varied level of digitalization implementation within these departments, with certain areas exhibiting lower rates of digitalization that could benefit from targeted improvement initiatives. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 5, 2023 Category: Cancer & Oncology Source Type: research
Low-dose radiotherapy of osteoarthritis: from biological findings to clinical effects —challenges for future studies
AbstractOsteoarthritis (OA) is one of the most common and socioeconomically relevant diseases, with rising incidence and prevalence especially with regard to an ageing population in the Western world. Over the decades, the scientific perception of OA has shifted from a simple degeneration of cartilage and bone to a multifactorial disease involving various cell types and immunomodulatory factors. Despite a wide range of conventional treatment modalities available, a significant proportion of patients remain treatment refractory. Low-dose radiotherapy (LDRT) ha s been used for decades in the treatment of patients with i...
Source: Strahlentherapie und Onkologie - December 1, 2023 Category: Cancer & Oncology Source Type: research
Chronic inflammatory effects of in vivo irradiation of the murine heart on endothelial cells mimic mechanisms involved in atherosclerosis
ConclusionThe long-lasting upregulation of prominent inflammatory markers on primary heart and lung ECs suggests that local heart irradiation induces chronic inflammation in the microvasculature of the heart and partially irradiated lung that leads to cardiac injury which might be related to altered lipid metabolism in the heart. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - December 1, 2023 Category: Cancer & Oncology Source Type: research
Advances in molecular targeted therapies to increase efficacy of (chemo)radiation therapy
AbstractRecent advances in understanding the tumor ’s biology in line with a constantly growing number of innovative technologies have prompted characterization of patients’ individual malignancies and may display a prerequisite to treat cancer at its patient individual tumor vulnerability. In recent decades, radiation- induced signaling and tum or promoting local events for radiation sensitization were explored in detail, resulting the development of novel molecular targets. A multitude of pharmacological, genetic, and immunological principles, including small molecule- and antibody-based targeted strategies, have be...
Source: Strahlentherapie und Onkologie - December 1, 2023 Category: Cancer & Oncology Source Type: research
