Kombination stereotaktischer Radiotherapie mit Checkpointinhibitoren: Ergebnisse der CHEERS-Phase-II-Studie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 19, 2023 Category: Cancer & Oncology Source Type: research

Das BRCA-like-Mammakarzinom profitiert von Cisplatin plus Veliparib; Ergebnisse der S1416-Phase-II-Studie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 12, 2023 Category: Cancer & Oncology Source Type: research

ArthroRad trial: randomized multicenter single-blinded trial on the effect of low-dose radiotherapy for painful osteoarthritis —final results after 12-month follow-up
ConclusionsWe found a  favorable pain relief and a limited response in the functional and quality of life scores in both treatment arms. The possible effect of low doses such as 0.3 Gy on pain is widely unknown. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 10, 2023 Category: Cancer & Oncology Source Type: research

Neoadjuvante Chemotherapie beim operablen Kolonkarzinom  – ein potenzieller neuer Standard?
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 10, 2023 Category: Cancer & Oncology Source Type: research

Radiotherapy for benign diseases in Turkey: a  patterns of care survey of the Turkish Society for Radiation Oncology (TROD 05-002)
ConclusionThe ratio of patients who underwent RT for benign diseases in Turkey among all patients who underwent RT was 4.85%. The common pattern of RT in 72% of patients was radiosurgery for intracranial benign diseases, followed by low-dose RT for plantar fasciitis in 19%. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 5, 2023 Category: Cancer & Oncology Source Type: research

Stereoscopic X-ray image and thermo-optical surface guidance for breast cancer radiotherapy in deep inspiration breath-hold
ConclusionDIBH treatments using thermo-optical SGRT and  X-ray IGRT were feasible for breast cancer patients. Stereoscopic X‑ray positioning was successfully verified by standard IGRT techniques. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 5, 2023 Category: Cancer & Oncology Source Type: research

Intraoperative radiotherapy (IORT) of early breast cancer with low-energy x-rays in breast-conserving surgery
ConclusionWe observed that preoperative ultrasound-based tumor –skin distance is a significant factor in addition to already known parameters to predict feasibility of IORT. Based on our findings we developed a formula to optimize IORT planning which might serve as an additional tool to improve patient selection for IORT in early breast cancer. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 4, 2023 Category: Cancer & Oncology Source Type: research

Risk assessment, surveillance, and nonpharmaceutical prevention of acute radiation dermatitis: results of a  multicentric survey among the German-speaking radiation oncology community
ConclusionIdentification of patients at an increased risk of RD and subsequent implementation of adequate preventive measures remain relevant and challenging aspects of clinical routines. Consensus exists on several risk factors and nonpharmaceutical prevention recommendations, while RT-dependent risk factors, e.g., the fractionation scheme, or hygienic measures like deodorant use remain controversial. Surveillance is widely lacking methodology and objectivity. Intensifying outreach in the radiation oncology community is needed to improve practice patterns. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2023 Category: Cancer & Oncology Source Type: research

Utility of pre-chemoradiotherapy Pan-Immune-Inflammation-Value for predicting the osteoradionecrosis rates in locally advanced nasopharyngeal cancers
ConclusionsOur findings revealed a  strong link between aggravated inflammatory response and ORN genesis, with high pretreatment PIV levels related to significantly higher ORN rates. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2023 Category: Cancer & Oncology Source Type: research

Impact of comorbidity scores and lifestyle factors in curative radiotherapy in laryngeal cancer
ConclusionsIn our cohort of patients treated with radio(chemo)therapy for laryngeal cancer, we found good therapeutic results and an acceptable side-effect profile. Statistically significant predictors of overall survival were the baseline PS, weight loss, anaemia, associated comorbidities, history of alcohol abuse and marital status. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2023 Category: Cancer & Oncology Source Type: research

Irradiation dose to the swallowing apparatus impacts nutritional status in head and neck cancer patients —results from the prospective randomized HEADNUT trial
ConclusionEstablishment of a  normal nutritional status before the start of RT and adherence to dose constraints for the swallowing apparatus may prevent malnutrition in head and neck cancer patients at the end of therapy. Specifically, we suggest an icm V40Gy (%) of more than 86% to be predictive for nutritional complications . (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2023 Category: Cancer & Oncology Source Type: research

Therapieentscheidungen beim hepatozellul ären Karzinom: Erkenntnisse aus der TRENDY-Studie
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2023 Category: Cancer & Oncology Source Type: research

The evolving role of reduced-dose total skin electron beam therapy in skin malignancies: the renaissance of a  rare indication
AbstractDefinitive radiation therapy is an effective local treatment for several cutaneous malignancies. Patients with diffuse or generalized skin manifestations might require total skin electron beam therapy (TSEBT) as an alternative treatment to the chasing technique. In this short communication, we highlight the evolving role of TSEBT and present its role in various forms of skin malignancies. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2023 Category: Cancer & Oncology Source Type: research

Stereotaktische Radiotherapie plus Nivolumab bei NSCLC
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 1, 2023 Category: Cancer & Oncology Source Type: research

Organerhaltende Behandlung bei nodal-positiven Harnblasenkarzinomen
(Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - September 29, 2023 Category: Cancer & Oncology Source Type: research