Proton Therapy Mediates Dose Reductions to Brain Structures Associated with Cognition in Children with Medulloblastoma
Background: Emerging evidence suggests proton radiotherapy may offer cognitive sparing advantages over photon radiotherapy, yet dosimetry has not been compared previously. The purpose of this study is to examine dosimetric correlates of cognitive outcomes in children with medulloblastoma treated with proton vs. photon radiotherapy.Methods: In this retrospective, bi-institutional study, dosimetric and cognitive data from 75 patients (39 photon and 36 proton) were analyzed. Doses to brain structures were compared between treatment modalities.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Julianna Sienna, Lisa S. Kahalley, Donald Mabbott, David Grosshans, Anna Theresa Santiago, Arnold dela Cruz Paulino, Thomas E. Merchant, Gohar S. Manzar, Hitesh Dama, David C. Hodgson, Murali Chintagumpala, Mehmet Fatih Okcu, William E. Whitehead, Normand Tags: Clinical Investigation Source Type: research
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