Mitochondrial calcium uniporter as biomarker and therapeutic target for breast cancer: Prognostication, immune microenvironment, epigenetic regulation and precision medicine
CONCLUSION: MCU shows significant implication in prognosis, outcome prediction, microenvironmental shaping and precision medicine for BC. miR-29a-mediated MCU inhibition exerts therapeutic effect in tumor growth and metastasis.PMID:38663838 | DOI:10.1016/j.jare.2024.04.015 (Source: Cell Research)
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Hung-Yu Lin Pei-Yi Chu Source Type: research
Cope with copper: From molecular mechanisms of cuproptosis to copper-related kidney diseases
Int Immunopharmacol. 2024 Apr 24;133:112075. doi: 10.1016/j.intimp.2024.112075. Online ahead of print.ABSTRACTCuproptosis has recently been identified as a novel regulatory mechanism of cell death. It is characterized by the accumulation of copper in mitochondria and its binding to acylated proteins. These characteristics lead to the downregulation of iron-sulfur cluster proteins and protein toxicity stress, ultimately resulting in cell death. Cuproptosis is distinct from other types of cell death, including necrosis, apoptosis, ferroptosis, and pyroptosis. Cu induces oxidative stress damage, protein acylation, and the oli...
Source: International Immunopharmacology - April 25, 2024 Category: Allergy & Immunology Authors: Yurong Zou Shukun Wu Xingli Xu Xiaoqiu Tan Shuang Yang Tangting Chen Jiong Zhang Shengqiang Li Wei Li Fang Wang Source Type: research
Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy
J Autoimmun. 2024 Apr 24;146:103234. doi: 10.1016/j.jaut.2024.103234. Online ahead of print.ABSTRACTNarcolepsy is a rare cause of hypersomnolence and may be associated or not with cataplexy, i.e. sudden muscle weakness. These forms are designated narcolepsy-type 1 (NT1) and -type 2 (NT2), respectively. Notable characteristics of narcolepsy are that most patients carry the HLA-DQB1*06:02 allele and NT1-patients have strongly decreased levels of hypocretin-1 (synonym orexin-A) in the cerebrospinal fluid (CSF). The pathogenesis of narcolepsy is still not completely understood but the strong HLA-bias and increased frequencies ...
Source: Journal of Autoimmunity - April 25, 2024 Category: Allergy & Immunology Authors: Alina Huth Ikram Ayoub Lucie Barateau Lisa Ann Gerdes Dany Severac Stefan Krebs Helmut Blum Hayrettin Tumani J ürgen Haas Brigitte Wildemann Tania K ümpfel Eduardo Beltr án Roland S Liblau Yves Dauvilliers Klaus Dornmair Source Type: research
Cycloheptylprodigiosin from marine bacterium Spartinivicinus ruber MCCC 1K03745 < sup > T < /sup > induces a novel form of cell death characterized by Golgi disruption and enhanced secretion of cathepsin D in Non-small cell lung cancer cell lines
In this study, cycloheptylprodigiosin (S-1) is extracted from marine bacterium Spartinivicinus ruber MCCC 1K03745T, and its anticancer property was investigated. It exhibits remarkable cytotoxicity against a panel of human lung cancer cell lines, with the IC50 values ranging from 84.89 nM to 661.2 nM. After 6 hours of treatment, S-1 gradually accumulates on mitochondria and lysosomes. While lower doses of S-1 induce cell cycle arrest, treatment with higher doses results in cell death in apoptotic independent manner in both NCI-H1299 and NCI-H460 cell lines. Interestingly, treatment with S-1 leads to the accumulation of LC3...
Source: European Journal of Pharmacology - April 25, 2024 Category: Drugs & Pharmacology Authors: Xiaosi Lin Le Dong Qing Miao Zhaobin Huang Fang Wang Source Type: research
Aflatoxin B < sub > 1 < /sub > -exposed hepatocyte-derived extracellular vesicles: Initiating hepatic stellate cell-mediated liver fibrosis through a p53-Parkin-dependent mitophagy pathway
This study further revealed that the hepatic fibrogenesis of AFB1 exposure was rescued by genetic intervention with siPARK2 or p53's Pifithrin-α (PFTα) inhibitors. Furthermore, AFB1-EVs-induced HSCs activation was relieved by GW4869 pharmaceutic inhibition of EVs secretion. These results revealed a novel mechanism that AFB1 exposure-induced p53-Parkin signal axis regulated mitophagy-dependent hepatocyte-derived EVs to mediate the mitochondria-trafficking intercellular communication between hepatocytes and HSCs in the local hepatotoxic microenvironment to promote the activated HSCs-associated liver fibrogenesis. Our study...
Source: Ecotoxicology and Environmental Safety - April 25, 2024 Category: Environmental Health Authors: Lei Yang Yun-Lu Gao Shan Jiang Bo Qian Lin Che Jia-Shen Wu Ze-Bang Du Ming-Zhu Wang Yun Yang Yu-Chun Lin Gang Liu Zhong-Ning Lin Source Type: research
Cope with copper: From molecular mechanisms of cuproptosis to copper-related kidney diseases
Int Immunopharmacol. 2024 Apr 24;133:112075. doi: 10.1016/j.intimp.2024.112075. Online ahead of print.ABSTRACTCuproptosis has recently been identified as a novel regulatory mechanism of cell death. It is characterized by the accumulation of copper in mitochondria and its binding to acylated proteins. These characteristics lead to the downregulation of iron-sulfur cluster proteins and protein toxicity stress, ultimately resulting in cell death. Cuproptosis is distinct from other types of cell death, including necrosis, apoptosis, ferroptosis, and pyroptosis. Cu induces oxidative stress damage, protein acylation, and the oli...
Source: International Immunopharmacology - April 25, 2024 Category: Allergy & Immunology Authors: Yurong Zou Shukun Wu Xingli Xu Xiaoqiu Tan Shuang Yang Tangting Chen Jiong Zhang Shengqiang Li Wei Li Fang Wang Source Type: research
Effect of epicatechin consumption on the inflammatory pathway and mitochondria morphology in PBMC from a R350P desminopathy patient: A case report
AbstractDesminopathy R350P is a human myopathy that is characterized by the progressive loss of muscle fiber organization. This results in the loss of muscle size, mobility, and strength. In desminopathy, inflammation affects muscle homeostasis and repair, and contributes to progressive muscle deterioration. Mitochondria morphology was also suggested to affect desminopathy progression. Epicatechin (Epi) —a natural compound found in cacao—has been proposed to regulate inflammatory signaling and mitochondria morphology in human and animal models. Hence, we hypothesize chronic Epi consumption to improve inflammatory pathw...
Source: Physiological Reports - April 25, 2024 Category: Physiology Authors: Germ án Tapia‐Curimil,
Mauricio Castro‐Sepulveda,
Hermann Zbinden‐Foncea Tags: CASE REPORT Source Type: research
Mitochondrial fractions located in the cytoplasmic and peridroplet areas of white adipocytes have distinct roles
White adipocytes contain two mitochondrial fractions: cytoplasmic mitochondria (CMw) and peridroplet mitochondria (PDMw). The formation of PDMw is partially regulated by perilipin 1 (PLIN1). CMw is responsible for β-oxidation, whereas PDMw is associated with diacylglycerol acyltransferase 2 (DGAT2) and contributes to the supply of triglycerides to lipid droplets. The role of mitochondria in white adipocytes (WAs) has not been fully explored. A recent study revealed that brown adipocytes contain functionally distinct mitochondrial fractions, cytoplasmic mitochondria, and peridroplet mitochondria. However, it is not known w...
Source: FEBS Letters - April 25, 2024 Category: Biochemistry Authors: Masayuki Fuwa,
Kazuo Kajita,
Ichiro Mori,
Motochika Asano,
Toshiko Kajita,
Takao Senda,
Takeshi Inagaki,
Hiroyuki Morita Tags: Research Article Source Type: research
α‐Hederin induces paraptosis by targeting GPCRs to activate Ca2+/MAPK signaling pathway in colorectal cancer
ConclusionsCollectively, our findings proved α-hed as a promising candidate for inducing non-apoptotic cell death, paraptosis. It may overcome the resistance of apoptotic-based chemo-resistance in CRC. (Source: Cancer Medicine)
Source: Cancer Medicine - April 25, 2024 Category: Cancer & Oncology Authors: Xiwu Rao,
Ziwen Li,
Qinchang Zhang,
Yueyang Lai,
Jianrong Liu,
Liu Li,
Haibo Cheng,
Weixing Shen,
Dongdong Sun Tags: RESEARCH ARTICLE Source Type: research
Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea
ConclusionsOur results indicate that the impact of CIH is dependent on sex, such as an inflammatory response and OS response in females and males, respectively, that are mediated by mtOS. Interestingly, there was no effect of sex or mtOS in CIH-induced impairment of recollective memory. These results indicate that mtOS is involved in the sex differences observed in CIH, but a different mechanism underlies CIH-induced memory impairments. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - April 25, 2024 Category: Biology Source Type: research
MSC-derived mitochondria promote axonal regeneration via Atf3 gene up-regulation by ROS induced DNA double strand breaks at transcription initiation region
The repair of peripheral nerve injury poses a clinical challenge, necessitating further investigation into novel therapeutic approaches. In recent years, bone marrow mesenchymal stromal cell (MSC)-derived mito... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 25, 2024 Category: Molecular Biology Authors: Yingchi Zhang, Tao Xu, Jie Xie, Hua Wu, Weihua Hu and Xuefeng Yuan Tags: Research Source Type: research
Beta hydroxybutyrate induces lung cancer cell death, mitochondrial impairment and oxidative stress in a long term glucose-restricted condition
CONCLUSION: The induced cell death, oxidative stress and mitochondria impairment beside attenuated levels of cancer stem cell markers following BHB administration emphasize on the distinctive role of metabolic plasticity of cancer cells and propose possible therapeutic approaches to control cancer cell growth through metabolic fuels.PMID:38656394 | DOI:10.1007/s11033-024-09501-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: Farzad Izak Shirian Milad Karimi Maryam Alipour Siamak Salami Mitra Nourbakhsh Samira Nekufar Nahid Safari-Alighiarloo Masoumeh Tavakoli-Yaraki Source Type: research
Beta hydroxybutyrate induces lung cancer cell death, mitochondrial impairment and oxidative stress in a long term glucose-restricted condition
CONCLUSION: The induced cell death, oxidative stress and mitochondria impairment beside attenuated levels of cancer stem cell markers following BHB administration emphasize on the distinctive role of metabolic plasticity of cancer cells and propose possible therapeutic approaches to control cancer cell growth through metabolic fuels.PMID:38656394 | DOI:10.1007/s11033-024-09501-w (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 24, 2024 Category: Molecular Biology Authors: Farzad Izak Shirian Milad Karimi Maryam Alipour Siamak Salami Mitra Nourbakhsh Samira Nekufar Nahid Safari-Alighiarloo Masoumeh Tavakoli-Yaraki Source Type: research
Regulatory role of PDK1 via integrated gene analysis of mitochondria-immune response in periodontitis
Gene. 2024 Apr 22:148476. doi: 10.1016/j.gene.2024.148476. Online ahead of print.ABSTRACTAIMS: To investigate the association between mitochondrial events and immune response in periodontitis and related regulatory genes.MAIN METHODS: Gene expression profiles in gingival tissues were retrieved from the Gene Expression Omnibus. Mitochondria-immune response-related differentially expressed genes (MIR-DEGs) between the healthy and periodontitis samples were determined. WGCNA, GO, and KEGG were used to investigate the function and the enriched pathways of MIR-DEGs. The correlation between MIR-DEGs expression and clinical probi...
Source: Gene - April 24, 2024 Category: Genetics & Stem Cells Authors: Xiaoyu Sun Tong Wu Zhan Yang Shuhong Chen Zheyu Zhao Chaoming Hu Shengzhuang Wu Jiayu Wu Yixin Mao Jiefan Liu Chen Guo Gang Cao Xiangwei Xu Shengbin Huang Guang Liang Source Type: research
Cardiomyocyte-specific deletion of the mitochondrial transporter Abcb10 causes cardiac dysfunction via lysosomal-mediated ferroptosis
Biosci Rep. 2024 Apr 24:BSR20231992. doi: 10.1042/BSR20231992. Online ahead of print.ABSTRACTHeart function is highly dependent on mitochondria, which not only produce energy but also regulate many cellular functions. Therefore, mitochondria are important therapeutic targets in heart failure. Abcb10 is a member of the ABC transporter superfamily located in the inner mitochondrial membrane and plays an important role in haemoglobin synthesis, biliverdin transport, antioxidant stress, and stabilization of the iron transporter mitoferrin-1. However, the mechanisms underlying the impairment of mitochondrial transporters in the...
Source: Bioscience Reports - April 24, 2024 Category: Biomedical Science Authors: Yura Do Mikako Yagi Haruka Hirai Kenji Miki Yukina Fikahori Daiki Setoyama Masatatsu Yamamoto Tatsuhiko Furukawa Yuya Kunishaki Dongchon Kang Takeshi Uchiumi Source Type: research
