HTD4010 attenuates myocardial injury in mice with septic cardiomyopathy by promoting autophagy < em > via < /em > the AMPK/mTOR signaling pathway
CONCLUSION: HTD4010 can attenuate myocardial injury in SCM mice possibly by promoting autophagy via modulating the AMPK/mTOR signaling pathway.PMID:38597442 | DOI:10.12122/j.issn.1673-4254.2024.03.12 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: H Xiao B Han J Guo C Wu J Wu Source Type: research
Development of Cu(II) 4-hydroxybenzoylhydrazone complexes that induce mitochondrial DNA damage and mitochondria-mediated apoptosis in liver cancer
In this study, two novel Cu(II) complexes (Cu1 and Cu2) were designed and synthesized. Notably, these Cu(II) complexes showed higher cytotoxicity against HL-7402 cells than cisplatin. Moreover, Cu(II) complexes significantly inhibited liver cancer growth in a xenograft model. A mechanism study revealed that the Cu(II) complexes reduced the mitochondrial membrane potential of cancer cells, produced excessive reactive oxygen species (ROS), induced mitochondrial DNA (mtDNA) damage, and ultimately facilitated cancer cell apoptosis.PMID:38599004 | DOI:10.1016/j.jinorgbio.2024.112550 (Source: Journal of Inorganic Biochemistry)
Source: Journal of Inorganic Biochemistry - April 10, 2024 Category: Biochemistry Authors: Ming Jiang Qiwei Yan Yuanping Fu Lili Meng Shuangshuang Gai Xiaohui Pan Yiming Qin Caiyun Jiang Source Type: research
MITOCHONDRIAL IMPORT STRESS and PINK1-MEDIATED MITOPHAGY: THE ROLE of the PINK1-TOMM-TIMM23 SUPERCOMPLEX
Autophagy. 2024 Apr 10. doi: 10.1080/15548627.2024.2340399. Online ahead of print.ABSTRACTMutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it recruits the E3 ubiquitin ligase PRKN/Parkin to mediate mitophagy. Upon mitochondrial import failure, PINK1 accumulates in association with the translocase of outer mitochondrial membrane (TOMM). However, the molecular basis of this PINK1 accumulation on the TOMM complex remain elusive. We recently demonstrated that TIMM23 (translocase of th...
Source: Autophagy - April 10, 2024 Category: Cytology Authors: Mohamed A Eldeeb Armaan Fallahi Andrea Soumbasis Andrew N Bayne Jean-Fran çois Trempe Edward A Fon Source Type: research
A novel probe to monitor lysosome-mitochondria contact sites opens up a new path to study neurodegenerative diseases
Cell Calcium. 2024 Apr 8;120:102887. doi: 10.1016/j.ceca.2024.102887. Online ahead of print.NO ABSTRACTPMID:38599095 | DOI:10.1016/j.ceca.2024.102887 (Source: Cell Calcium)
Source: Cell Calcium - April 10, 2024 Category: Cytology Authors: Mai Makino Shuhei Nakamura Source Type: research
The structural and functional modularity of ovarian follicle epithelium in the pill-millipede Hyleoglomeris japonica Verhoeff, 1936 (Diplopoda: Glomerida: Glomeridae)
We report here two structurally and developmentally distinct domains within the follicle epithelium of the Japanese pill millipede, Hyleoglomeris japonica. The follicle epithelium of H. japonica exhibits a thick cell mass at the apex of the follicle. These cells harbor abundant rough endoplasmic reticulum, mitochondria, Golgi complexes, and numerous microvilli, indicative of synthetic/secretory activities. Moreover, their height increases as oogenesis progresses. In contrast, another region of the epithelium lacks these features. Our findings highlight the presence of structural and functional modularity in the follicle ep...
Source: Tissue and Cell - April 10, 2024 Category: Cytology Authors: Yasuhiko Chikami Kensuke Yahata Source Type: research
Association of poly( < em > rC < /em > )-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria
In conclusion, we discovered a novel pathway of iron entry into mitochondria from cytosol through PCBP2-TOM20-SFXN3 axis.PMID:38599240 | DOI:10.1080/10715762.2024.2340711 (Source: Free Radical Research)
Source: Free Radical Research - April 10, 2024 Category: Research Authors: Danyang Mi Izumi Yanatori Hao Zheng Yingyi Kong Tasuku Hirayama Shinya Toyokuni Source Type: research
Deciphering mitochondrial dysfunction: Pathophysiological mechanisms in vascular cognitive impairment
Biomed Pharmacother. 2024 Apr 9;174:116428. doi: 10.1016/j.biopha.2024.116428. Online ahead of print.ABSTRACTVascular cognitive impairment (VCI) encompasses a range of cognitive deficits arising from vascular pathology. The pathophysiological mechanisms underlying VCI remain incompletely understood; however, chronic cerebral hypoperfusion (CCH) is widely acknowledged as a principal pathological contributor. Mitochondria, crucial for cellular energy production and intracellular signaling, can lead to numerous neurological impairments when dysfunctional. Recent evidence indicates that mitochondrial dysfunction-marked by oxid...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2024 Category: Drugs & Pharmacology Authors: Yuyao He Tiantian He Hongpei Li Wei Chen Biying Zhong Yue Wu Runming Chen Yuli Hu Huaping Ma Bin Wu Wenyue Hu Zhenyun Han Source Type: research
Mitochondrial morphology, distribution and activity during oocyte development
Trends Endocrinol Metab. 2024 Apr 9:S1043-2760(24)00064-X. doi: 10.1016/j.tem.2024.03.002. Online ahead of print.ABSTRACTMitochondria have a crucial role in cellular function and exhibit remarkable plasticity, adjusting both their structure and activity to meet the changing energy demands of a cell. Oocytes, female germ cells that become eggs, undergo unique transformations: the extended dormancy period, followed by substantial increase in cell size and subsequent maturation involving the segregation of genetic material for the next generation, present distinct metabolic challenges necessitating varied mitochondrial adapta...
Source: Trends in Endocrinology and Metabolism: TEM - April 10, 2024 Category: Endocrinology Authors: Devesh Bahety Elvan B öke Aida Rodr íguez-Nuevo Source Type: research
Alkaline sphingomyelinase deficiency impairs intestinal mucosal barrier integrity and reduces antioxidant capacity in dextran sulfate sodium-induced colitis
CONCLUSION: Alk-SMase regulates the stability of the intestinal mucosal barrier and enhances antioxidant activity through the Nrf2 signaling pathway.PMID:38596488 | PMC:PMC11000083 | DOI:10.3748/wjg.v30.i10.1405 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Ye Tian Xin Li Xu Wang Si-Ting Pei Hong-Xin Pan Yu-Qi Cheng Yi-Chen Li Wen-Ting Cao Jin-Dong Ding Petersen Ping Zhang Source Type: research
Alkaline sphingomyelinase deficiency impairs intestinal mucosal barrier integrity and reduces antioxidant capacity in dextran sulfate sodium-induced colitis
CONCLUSION: Alk-SMase regulates the stability of the intestinal mucosal barrier and enhances antioxidant activity through the Nrf2 signaling pathway.PMID:38596488 | PMC:PMC11000083 | DOI:10.3748/wjg.v30.i10.1405 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Ye Tian Xin Li Xu Wang Si-Ting Pei Hong-Xin Pan Yu-Qi Cheng Yi-Chen Li Wen-Ting Cao Jin-Dong Ding Petersen Ping Zhang Source Type: research
HTD4010 attenuates myocardial injury in mice with septic cardiomyopathy by promoting autophagy < em > via < /em > the AMPK/mTOR signaling pathway
CONCLUSION: HTD4010 can attenuate myocardial injury in SCM mice possibly by promoting autophagy via modulating the AMPK/mTOR signaling pathway.PMID:38597442 | PMC:PMC11006686 | DOI:10.12122/j.issn.1673-4254.2024.03.12 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: H Xiao B Han J Guo C Wu J Wu Source Type: research
Development of Cu(II) 4-hydroxybenzoylhydrazone complexes that induce mitochondrial DNA damage and mitochondria-mediated apoptosis in liver cancer
In this study, two novel Cu(II) complexes (Cu1 and Cu2) were designed and synthesized. Notably, these Cu(II) complexes showed higher cytotoxicity against HL-7402 cells than cisplatin. Moreover, Cu(II) complexes significantly inhibited liver cancer growth in a xenograft model. A mechanism study revealed that the Cu(II) complexes reduced the mitochondrial membrane potential of cancer cells, produced excessive reactive oxygen species (ROS), induced mitochondrial DNA (mtDNA) damage, and ultimately facilitated cancer cell apoptosis.PMID:38599004 | DOI:10.1016/j.jinorgbio.2024.112550 (Source: Journal of Inorganic Biochemistry)
Source: Journal of Inorganic Biochemistry - April 10, 2024 Category: Biochemistry Authors: Ming Jiang Qiwei Yan Yuanping Fu Lili Meng Shuangshuang Gai Xiaohui Pan Yiming Qin Caiyun Jiang Source Type: research
A novel probe to monitor lysosome-mitochondria contact sites opens up a new path to study neurodegenerative diseases
Cell Calcium. 2024 Apr 8;120:102887. doi: 10.1016/j.ceca.2024.102887. Online ahead of print.NO ABSTRACTPMID:38599095 | DOI:10.1016/j.ceca.2024.102887 (Source: Cell Calcium)
Source: Cell Calcium - April 10, 2024 Category: Cytology Authors: Mai Makino Shuhei Nakamura Source Type: research
Association of poly( < em > rC < /em > )-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria
In conclusion, we discovered a novel pathway of iron entry into mitochondria from cytosol through PCBP2-TOM20-SFXN3 axis.PMID:38599240 | DOI:10.1080/10715762.2024.2340711 (Source: Free Radical Research)
Source: Free Radical Research - April 10, 2024 Category: Research Authors: Danyang Mi Izumi Yanatori Hao Zheng Yingyi Kong Tasuku Hirayama Shinya Toyokuni Source Type: research
Mitochondrial morphology, distribution and activity during oocyte development
Trends Endocrinol Metab. 2024 Apr 9:S1043-2760(24)00064-X. doi: 10.1016/j.tem.2024.03.002. Online ahead of print.ABSTRACTMitochondria have a crucial role in cellular function and exhibit remarkable plasticity, adjusting both their structure and activity to meet the changing energy demands of a cell. Oocytes, female germ cells that become eggs, undergo unique transformations: the extended dormancy period, followed by substantial increase in cell size and subsequent maturation involving the segregation of genetic material for the next generation, present distinct metabolic challenges necessitating varied mitochondrial adapta...
Source: Trends in Endocrinology and Metabolism: TEM - April 10, 2024 Category: Endocrinology Authors: Devesh Bahety Elvan B öke Aida Rodr íguez-Nuevo Source Type: research
