Recent advances in toxicological research of di-(2-ethylhexyl)-phthalate: Focus on endoplasmic reticulum stress pathway
This study offers possible targets and approaches for addressing various DEHP-induced toxicity.PMID:38593956 | DOI:10.1016/j.chemosphere.2024.141922 (Source: Chemosphere)
Source: Chemosphere - April 9, 2024 Category: Chemistry Authors: Jiten Singh Dinesh Kumar Ashok Jangra Source Type: research
Human mitochondrial glutathione transferases: Kinetic parameters and accommodation of a mitochondria-targeting group in substrates
Bioorg Med Chem. 2024 Apr 3;104:117712. doi: 10.1016/j.bmc.2024.117712. Online ahead of print.ABSTRACTGlutathione-S-transferases are key to the cellular detoxification of xenobiotics and products of oxidative damage. GSTs catalyse the reaction of glutathione (GSH) with electrophiles to form stable thioether adducts. GSTK1-1 is the main GST isoform in the mitochondrial matrix, but the GSTA1-1 and GSTA4-4 isoforms are also thought to be in the mitochondria with their distribution altering in transformed cells, thus potentially providing a cancer specific target. A mitochondria-targeted version of the GST substrate 1-chloro-2...
Source: Bioorganic and Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Patrick A Cardwell Carlo Del Moro Michael P Murphy Adrian J Lapthorn Richard C Hartley Source Type: research
Targeting Mitochondrial Complex I Deficiency in MPP < sup > + < /sup > /MPTP-induced Parkinson's Disease Cell Culture and Mouse Models by Transducing Yeast NDI1 Gene
CONCLUSIONS: NDI1 compensates for the defective complex I in MPP+/MPTP-induced models, and vastly alleviates MPTP-induced toxic effect on dopaminergic neurons. Our study may provide a basis for gene therapy of sporadic PD with defective complex I caused by MPTP-like substance.PMID:38594619 | DOI:10.1186/s12575-024-00236-3 (Source: Biological Procedures Online)
Source: Biological Procedures Online - April 9, 2024 Category: Molecular Biology Authors: Hongzhi Li Jing Zhang Yuqi Shen Yifan Ye Qingyou Jiang Lan Chen Bohao Sun Zhuo Chen Luxi Shen Hezhi Fang Jifeng Yang Haihua Gu Source Type: research
Recent advances in toxicological research of di-(2-ethylhexyl)-phthalate: Focus on endoplasmic reticulum stress pathway
This study offers possible targets and approaches for addressing various DEHP-induced toxicity.PMID:38593956 | DOI:10.1016/j.chemosphere.2024.141922 (Source: Chemosphere)
Source: Chemosphere - April 9, 2024 Category: Chemistry Authors: Jiten Singh Dinesh Kumar Ashok Jangra Source Type: research
Capsiate ameliorates secondary hyperparathyroidism by improving insulin sensitivity and inhibiting angiogenesis
This study aims to evaluate the effects and mechanisms of capsiates in the treatment of secondary hyperparathyroidism. To achieve our research objectives, we conducted a study on patients' serum and examined changes in metabolic markers using serum metabolomics. We induced secondary hyperparathyroidism in rat through dietary intervention and divided them into four groups. The first group, referred to as the Parathyroid Hormone (PTH) group, received a low-calcium and high-phosphate diet (0.2% calcium, 1.2% phosphorus). The second group served as the control group, receiving a standard phosphate and calcium diet (0.6% calciu...
Source: J Cell Mol Med - April 9, 2024 Category: Molecular Biology Authors: Peiting Li Jianda Zhou Tianyin Wang Jun Li Wei Wu Source Type: research
Alleviating Neurodegenerative Diseases Associated with Mitochondrial Defects by Therapeutic Biomolecules
Curr Top Med Chem. 2024 Apr 5. doi: 10.2174/0115680266299148240329062647. Online ahead of print.ABSTRACTNeurodegenerative diseases are emerging as a global health concern in the current sce-nario, and their association with mitochondrial defects has been a potential area of research. Mi-tochondria, one of the essential organelles of the cell, serve as the cell's powerhouse, producing energy and ensuring cellular health. Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and Pelizaeus-Merzbacher disease have been found to be primarily triggered by mitochondrial malfunct...
Source: Current Topics in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Tanmoy Roy Swarupanjali Padhi Rupa Mazumder Chandana Majee Saumya Das Monika Monika Rashmi Mishra Bhupinder Kapoor Source Type: research
Capsiate ameliorates secondary hyperparathyroidism by improving insulin sensitivity and inhibiting angiogenesis
This study aims to evaluate the effects and mechanisms of capsiates in the treatment of secondary hyperparathyroidism. To achieve our research objectives, we conducted a study on patients' serum and examined changes in metabolic markers using serum metabolomics. We induced secondary hyperparathyroidism in rat through dietary intervention and divided them into four groups. The first group, referred to as the Parathyroid Hormone (PTH) group, received a low-calcium and high-phosphate diet (0.2% calcium, 1.2% phosphorus). The second group served as the control group, receiving a standard phosphate and calcium diet (0.6% calciu...
Source: Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Peiting Li Jianda Zhou Tianyin Wang Jun Li Wei Wu Source Type: research
Matrix mechanics regulates muscle regeneration by modulating kinesin-1 activity
Biomaterials. 2024 Mar 29;308:122551. doi: 10.1016/j.biomaterials.2024.122551. Online ahead of print.ABSTRACTSarcopenia, a prevalent muscle disease characterized by muscle mass and strength reduction, is associated with impaired skeletal muscle regeneration. However, the influence of the biomechanical properties of sarcopenic skeletal muscle on the efficiency of the myogenic program remains unclear. Herein, we established a mouse model of sarcopenia and observed a reduction in stiffness within the sarcopenic skeletal muscle in vivo. To investigate whether the biomechanical properties of skeletal muscle directly impact the ...
Source: Biomaterials - April 9, 2024 Category: Materials Science Authors: Wan-Yu Chiang Helen Wenshin Yu Ming-Chung Wu Yi-Man Huang Yin-Quan Chen Jong-Wei Lin Yen-Wenn Liu Li-Ru You Arthur Chiou Jean-Cheng Kuo Source Type: research
Elucidating the intricacies of the H < sub > 2 < /sub > S signaling pathway in gasotransmitters: Highlighting the regulation of plant thiocyanate detoxification pathways
Ecotoxicol Environ Saf. 2024 Apr 8;276:116307. doi: 10.1016/j.ecoenv.2024.116307. Online ahead of print.ABSTRACTIn recent decades, there has been increasing interest in elucidating the role of sulfur-containing compounds in plant metabolism, particularly emphasizing their function as signaling molecules. Among these, thiocyanate (SCN-), a compound imbued with sulfur and nitrogen, has emerged as a significant environmental contaminant frequently detected in irrigation water. This compound is known for its potential to adversely impact plant growth and agricultural yield. Although adopting exogenous SCN- as a nitrogen source...
Source: Ecotoxicology and Environmental Safety - April 9, 2024 Category: Environmental Health Authors: Yu-Xi Feng Peng Tian Cheng-Zhi Li Xiao-Dong Hu Yu-Juan Lin Source Type: research
Recent advances in toxicological research of di-(2-ethylhexyl)-phthalate: Focus on endoplasmic reticulum stress pathway
This study offers possible targets and approaches for addressing various DEHP-induced toxicity.PMID:38593956 | DOI:10.1016/j.chemosphere.2024.141922 (Source: Chemosphere)
Source: Chemosphere - April 9, 2024 Category: Chemistry Authors: Jiten Singh Ashok Jangra Dinesh Kumar Source Type: research
Human mitochondrial glutathione transferases: Kinetic parameters and accommodation of a mitochondria-targeting group in substrates
Bioorg Med Chem. 2024 Apr 3;104:117712. doi: 10.1016/j.bmc.2024.117712. Online ahead of print.ABSTRACTGlutathione-S-transferases are key to the cellular detoxification of xenobiotics and products of oxidative damage. GSTs catalyse the reaction of glutathione (GSH) with electrophiles to form stable thioether adducts. GSTK1-1 is the main GST isoform in the mitochondrial matrix, but the GSTA1-1 and GSTA4-4 isoforms are also thought to be in the mitochondria with their distribution altering in transformed cells, thus potentially providing a cancer specific target. A mitochondria-targeted version of the GST substrate 1-chloro-2...
Source: Bioorganic and Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Patrick A Cardwell Carlo Del Moro Michael P Murphy Adrian J Lapthorn Richard C Hartley Source Type: research
Targeting Mitochondrial Complex I Deficiency in MPP < sup > + < /sup > /MPTP-induced Parkinson's Disease Cell Culture and Mouse Models by Transducing Yeast NDI1 Gene
CONCLUSIONS: NDI1 compensates for the defective complex I in MPP+/MPTP-induced models, and vastly alleviates MPTP-induced toxic effect on dopaminergic neurons. Our study may provide a basis for gene therapy of sporadic PD with defective complex I caused by MPTP-like substance.PMID:38594619 | PMC:PMC11003148 | DOI:10.1186/s12575-024-00236-3 (Source: Biological Procedures Online)
Source: Biological Procedures Online - April 9, 2024 Category: Molecular Biology Authors: Hongzhi Li Jing Zhang Yuqi Shen Yifan Ye Qingyou Jiang Lan Chen Bohao Sun Zhuo Chen Luxi Shen Hezhi Fang Jifeng Yang Haihua Gu Source Type: research
Recent advances in toxicological research of di-(2-ethylhexyl)-phthalate: Focus on endoplasmic reticulum stress pathway
This study offers possible targets and approaches for addressing various DEHP-induced toxicity.PMID:38593956 | DOI:10.1016/j.chemosphere.2024.141922 (Source: Chemosphere)
Source: Chemosphere - April 9, 2024 Category: Chemistry Authors: Jiten Singh Ashok Jangra Dinesh Kumar Source Type: research
Capsiate ameliorates secondary hyperparathyroidism by improving insulin sensitivity and inhibiting angiogenesis
This study aims to evaluate the effects and mechanisms of capsiates in the treatment of secondary hyperparathyroidism. To achieve our research objectives, we conducted a study on patients' serum and examined changes in metabolic markers using serum metabolomics. We induced secondary hyperparathyroidism in rat through dietary intervention and divided them into four groups. The first group, referred to as the Parathyroid Hormone (PTH) group, received a low-calcium and high-phosphate diet (0.2% calcium, 1.2% phosphorus). The second group served as the control group, receiving a standard phosphate and calcium diet (0.6% calciu...
Source: J Cell Mol Med - April 9, 2024 Category: Molecular Biology Authors: Peiting Li Jianda Zhou Tianyin Wang Jun Li Wei Wu Source Type: research
Alleviating Neurodegenerative Diseases Associated with Mitochondrial Defects by Therapeutic Biomolecules
Curr Top Med Chem. 2024 Apr 5. doi: 10.2174/0115680266299148240329062647. Online ahead of print.ABSTRACTNeurodegenerative diseases are emerging as a global health concern in the current sce-nario, and their association with mitochondrial defects has been a potential area of research. Mi-tochondria, one of the essential organelles of the cell, serve as the cell's powerhouse, producing energy and ensuring cellular health. Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and Pelizaeus-Merzbacher disease have been found to be primarily triggered by mitochondrial malfunct...
Source: Current Topics in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Tanmoy Roy Swarupanjali Padhi Rupa Mazumder Chandana Majee Saumya Das Monika Monika Rashmi Mishra Bhupinder Kapoor Source Type: research
