Targeting Mitochondrial Complex I Deficiency in MPP < sup > + < /sup > /MPTP-induced Parkinson's Disease Cell Culture and Mouse Models by Transducing Yeast NDI1 Gene

CONCLUSIONS: NDI1 compensates for the defective complex I in MPP+/MPTP-induced models, and vastly alleviates MPTP-induced toxic effect on dopaminergic neurons. Our study may provide a basis for gene therapy of sporadic PD with defective complex I caused by MPTP-like substance.PMID:38594619 | PMC:PMC11003148 | DOI:10.1186/s12575-024-00236-3

Source: Biological Procedures Online - April 9, 2024 Category: Molecular Biology Authors: Hongzhi Li Jing Zhang Yuqi Shen Yifan Ye Qingyou Jiang Lan Chen Bohao Sun Zhuo Chen Luxi Shen Hezhi Fang Jifeng Yang Haihua Gu Source Type: research