Ferroptosis contributes to airway epithelial E-cadherin disruption in a mixed granulocytic asthma mouse model
This study was aimed to evaluate the role of ferroptosis and to investigate whether ferroptosis mediates E-cadherin disruption in mixed granulocyte asthma (MGA). Two murine models of MGA were established using toluene diisocyanate (TDI) or ovalbumin with Complete Freund's Adjuvant (OVA/CFA). Specific antagonists of ferroptosis, including Liproxstatin-1 (Lip-1) and Ferrostatin-1 (Fer-1) were given to the mice. The allergen-exposed mice displayed markedly shrunk mitochondria in the airway epithelia, with decreased volume and denser staining accompanied by down-regulated GPX4 as well as up-regulated FTH1 and malondialdehyde, ...
Source: Experimental Cell Research - April 12, 2024 Category: Cytology Authors: Sudan Gan Liqin Lin Zemin Chen Hailing Zhang Haixiong Tang Changyun Yang Jing Li Shiyue Li Lihong Yao Source Type: research
Cytosolic RNA binding of the mitochondrial TCA cycle enzyme malate dehydrogenase (MDH2)
RNA. 2024 Apr 12:rna.079925.123. doi: 10.1261/rna.079925.123. Online ahead of print.ABSTRACTSeveral enzymes of intermediary metabolism have been identified to bind RNA in 2 cells, with potential consequences for the bound RNAs and/or the enzyme. In this 3 study, we investigate the RNA-binding activity of the mitochondrial enzyme malate 4 dehydrogenase 2 (MDH2), which functions in the tricarboxylic acid (TCA) cycle and 5 the malate-aspartate shuttle. We confirmed in cellulo RNA-binding of MDH2 using 6 orthogonal biochemical assays and performed enhanced crosslinking and 7 immunoprecipitation (eCLIP) to identify the cellular...
Source: RNA - April 12, 2024 Category: Genetics & Stem Cells Authors: Michelle Noble Aindrila Chatterjee Thileepan Sekaran Thomas Schwarzl Matthias W Hentze Source Type: research
Asymmetric silicon phthalocyanine based nanoparticle with spatiotemporally targeting of mitochondria for synergistic apoptosis-ferroptosis antitumor treatment
This study offers compelling evidence that FECTPN can effectively induce ferroptosis and reinforces the paradigm of a synergistic apoptosis-ferroptosis pathway in cancer therapy, proposing a novel route for augmented antitumor treatments.PMID:38608462 | DOI:10.1016/j.colsurfb.2024.113890 (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - April 12, 2024 Category: Biotechnology Authors: Yan Huang Guowei Liu Fangmei Zheng Jianling Chen Youyu Lin Junwei Wang Yide Huang Yiru Peng Source Type: research
Membraneless and Membrane-bound Organelles in an Anhydrobiotic Cell Line are Protected from Desiccation-induced Damage
This study offers several exciting avenues for future studies in the animal model and Pv11 cell line that will further our understanding of anhydrobiosis and may lead to advancements in storing sensitive biologics at ambient temperatures for months or years.PMID:38608858 | DOI:10.1016/j.cstres.2024.04.002 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - April 12, 2024 Category: Cytology Authors: Clinton J Belott Oleg A Gusev Takahiro Kikawada Michael A Menze Source Type: research
Membraneless and Membrane-bound Organelles in an Anhydrobiotic Cell Line are Protected from Desiccation-induced Damage
This study offers several exciting avenues for future studies in the animal model and Pv11 cell line that will further our understanding of anhydrobiosis and may lead to advancements in storing sensitive biologics at ambient temperatures for months or years.PMID:38608858 | DOI:10.1016/j.cstres.2024.04.002 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - April 12, 2024 Category: Cytology Authors: Clinton J Belott Oleg A Gusev Takahiro Kikawada Michael A Menze Source Type: research
Membraneless and membrane-bound organelles in an anhydrobiotic cell line are protected from desiccation-induced damage
This study offers several exciting avenues for future studies in the animal model and Pv11 cell line that will further our understanding of anhydrobiosis and may lead to advancements in storing sensitive biologics at ambient temperatures for months or years.PMID:38608858 | DOI:10.1016/j.cstres.2024.04.002 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - April 12, 2024 Category: Cytology Authors: Clinton J Belott Oleg A Gusev Takahiro Kikawada Michael A Menze Source Type: research
A prognostic model of idiopathic pulmonary fibrosis constructed based on macrophage and mitochondria-related genes
Studies have shown that mitochondrial function and macrophages may play a role in the development of idiopathic pulmonary fibrosis (IPF). However, the understanding of the interactions and specific mechanisms ... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - April 12, 2024 Category: Respiratory Medicine Authors: Yu Bao, Shiyuan Yang, Hailan Zhao, Yezhen Wang, Ke Li, Xue Liu, Wei Zhang and Xue Zhu Tags: Research Source Type: research
Mechanical stress induced mitochondrial dysfunction in cardiovascular diseases: Novel mechanisms and therapeutic targets
Biomed Pharmacother. 2024 Apr 10;174:116545. doi: 10.1016/j.biopha.2024.116545. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Others and our studies have shown that mechanical stresses (forces) including shear stress and cyclic stretch, occur in various pathological conditions, play significant roles in the development and progression of CVDs. Mitochondria regulate the physiological processes of cardiac and vascular cells mainly through adenosine triphosphate (ATP) production, calcium flux and redox control while promote cell death through electron transport comp...
Source: Atherosclerosis - April 11, 2024 Category: Cardiology Authors: He Ren Weiyi Hu Tao Jiang Qingping Yao Yingxin Qi Kai Huang Source Type: research
Mechanical stress induced mitochondrial dysfunction in cardiovascular diseases: Novel mechanisms and therapeutic targets
Biomed Pharmacother. 2024 Apr 10;174:116545. doi: 10.1016/j.biopha.2024.116545. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Others and our studies have shown that mechanical stresses (forces) including shear stress and cyclic stretch, occur in various pathological conditions, play significant roles in the development and progression of CVDs. Mitochondria regulate the physiological processes of cardiac and vascular cells mainly through adenosine triphosphate (ATP) production, calcium flux and redox control while promote cell death through electron transport comp...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 11, 2024 Category: Drugs & Pharmacology Authors: He Ren Weiyi Hu Tao Jiang Qingping Yao Yingxin Qi Kai Huang Source Type: research
Mechanical stress induced mitochondrial dysfunction in cardiovascular diseases: Novel mechanisms and therapeutic targets
Biomed Pharmacother. 2024 Apr 10;174:116545. doi: 10.1016/j.biopha.2024.116545. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Others and our studies have shown that mechanical stresses (forces) including shear stress and cyclic stretch, occur in various pathological conditions, play significant roles in the development and progression of CVDs. Mitochondria regulate the physiological processes of cardiac and vascular cells mainly through adenosine triphosphate (ATP) production, calcium flux and redox control while promote cell death through electron transport comp...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 11, 2024 Category: Drugs & Pharmacology Authors: He Ren Weiyi Hu Tao Jiang Qingping Yao Yingxin Qi Kai Huang Source Type: research
MITOCHONDRIAL IMPORT STRESS and PINK1-MEDIATED MITOPHAGY: THE ROLE of the PINK1-TOMM-TIMM23 SUPERCOMPLEX
Autophagy. 2024 Apr 10. doi: 10.1080/15548627.2024.2340399. Online ahead of print.ABSTRACTMutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it recruits the E3 ubiquitin ligase PRKN/Parkin to mediate mitophagy. Upon mitochondrial import failure, PINK1 accumulates in association with the translocase of outer mitochondrial membrane (TOMM). However, the molecular basis of this PINK1 accumulation on the TOMM complex remain elusive. We recently demonstrated that TIMM23 (translocase of th...
Source: Autophagy - April 10, 2024 Category: Cytology Authors: Mohamed A Eldeeb Armaan Fallahi Andrea Soumbasis Andrew N Bayne Jean-Fran çois Trempe Edward A Fon Source Type: research
Deciphering mitochondrial dysfunction: Pathophysiological mechanisms in vascular cognitive impairment
Biomed Pharmacother. 2024 Apr 9;174:116428. doi: 10.1016/j.biopha.2024.116428. Online ahead of print.ABSTRACTVascular cognitive impairment (VCI) encompasses a range of cognitive deficits arising from vascular pathology. The pathophysiological mechanisms underlying VCI remain incompletely understood; however, chronic cerebral hypoperfusion (CCH) is widely acknowledged as a principal pathological contributor. Mitochondria, crucial for cellular energy production and intracellular signaling, can lead to numerous neurological impairments when dysfunctional. Recent evidence indicates that mitochondrial dysfunction-marked by oxid...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2024 Category: Drugs & Pharmacology Authors: Yuyao He Tiantian He Hongpei Li Wei Chen Biying Zhong Yue Wu Runming Chen Yuli Hu Huaping Ma Bin Wu Wenyue Hu Zhenyun Han Source Type: research
Mitochondrial morphology, distribution and activity during oocyte development
Trends Endocrinol Metab. 2024 Apr 9:S1043-2760(24)00064-X. doi: 10.1016/j.tem.2024.03.002. Online ahead of print.ABSTRACTMitochondria have a crucial role in cellular function and exhibit remarkable plasticity, adjusting both their structure and activity to meet the changing energy demands of a cell. Oocytes, female germ cells that become eggs, undergo unique transformations: the extended dormancy period, followed by substantial increase in cell size and subsequent maturation involving the segregation of genetic material for the next generation, present distinct metabolic challenges necessitating varied mitochondrial adapta...
Source: Trends in Endocrinology and Metabolism: TEM - April 10, 2024 Category: Endocrinology Authors: Devesh Bahety Elvan B öke Aida Rodr íguez-Nuevo Source Type: research
Alkaline sphingomyelinase deficiency impairs intestinal mucosal barrier integrity and reduces antioxidant capacity in dextran sulfate sodium-induced colitis
CONCLUSION: Alk-SMase regulates the stability of the intestinal mucosal barrier and enhances antioxidant activity through the Nrf2 signaling pathway.PMID:38596488 | PMC:PMC11000083 | DOI:10.3748/wjg.v30.i10.1405 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Ye Tian Xin Li Xu Wang Si-Ting Pei Hong-Xin Pan Yu-Qi Cheng Yi-Chen Li Wen-Ting Cao Jin-Dong Ding Petersen Ping Zhang Source Type: research
Alkaline sphingomyelinase deficiency impairs intestinal mucosal barrier integrity and reduces antioxidant capacity in dextran sulfate sodium-induced colitis
CONCLUSION: Alk-SMase regulates the stability of the intestinal mucosal barrier and enhances antioxidant activity through the Nrf2 signaling pathway.PMID:38596488 | PMC:PMC11000083 | DOI:10.3748/wjg.v30.i10.1405 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Ye Tian Xin Li Xu Wang Si-Ting Pei Hong-Xin Pan Yu-Qi Cheng Yi-Chen Li Wen-Ting Cao Jin-Dong Ding Petersen Ping Zhang Source Type: research
