Alpha-lipoic Acid: An Antioxidant with Anti-Aging Properties for Disease Therapy
Curr Med Chem. 2024 Apr 19. doi: 10.2174/0109298673300496240416114827. Online ahead of print.ABSTRACTThe anti-aging effects of alpha-lipoic acid (αLA), a natural antioxidant synthesized in human tissues, have attracted a growing interest in recent years. αLA is a short- -chain sulfur-containing fatty acid occurring in the mitochondria of all kinds of eukaryotic cells. Both the oxidized disulfide of αLA and its reduced form (dihydrolipoic acid, DHLA) exhibit prominent antioxidant function. The amount of αLA inside the human body gradually decreases with age resulting in various health disorders. Its lack can be compensa...
Source: Current Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Mariia Shanaida Roman Lysiuk Olha Mykhailenko Nataliia Hudz Abdullateef Abdulsalam Tetiana Gontova Oleksandra Oleshchuk Yana Ivankiv Volodymyr Shanaida Dmytro Lytkin Geir Bj ørklund Source Type: research
Mitochondrial Physiology of Cellular Redox Regulations
Physiol Res. 2024 Apr 22. Online ahead of print.ABSTRACTMitochondria (mt) represent the vital hub of the molecular physiology of the cell, being decision-makers in cell life/death and information signaling, including major redox regulations and redox signaling. Now we review recent advances in understanding mitochondrial redox homeostasis, including superoxide sources and H2O2 consumers, i.e., antioxidant mechanisms, as well as exemplar situations of physiological redox signaling, including the intramitochondrial one and mt-to-cytosol redox signals, which may be classified as acute and long-term signals. This review exempl...
Source: Physiological Research - April 22, 2024 Category: Physiology Authors: P Je žek A Dlaskov á H Engstov á J Špačková J Tauber P Pr ůchová E Kloppel O Mozheitova M Jab ůrek Source Type: research
Effect of the Mitochondrial Transaminase (GOT2) on Membrane Potential Sensitive Respiration in Mitochondria of Differentiated C2C12 Muscle Cells
Am J Physiol Cell Physiol. 2024 Apr 22. doi: 10.1152/ajpcell.00576.2023. Online ahead of print.ABSTRACTWe previously showed that the transaminase inhibitor, aminooxyacetic acid, reduced respiration energized at complex II (succinate dehydrogenase, SDH) in mitochondria isolated from mouse hindlimb muscle. The effect required a reduction in membrane potential with resultant accumulation of oxaloacetate (OAA), a potent inhibitor of SDH. To specifically assess the effect of the mitochondrial transaminase, glutamic oxaloacetic transaminase (GOT2) on complex II respiration and to determine the effect in intact cells as well as i...
Source: Am J Physiol Cell Ph... - April 22, 2024 Category: Cytology Authors: Ritu Som Brian D Fink Liping Yu William I Sivitz Source Type: research
Effect of the Mitochondrial Transaminase (GOT2) on Membrane Potential Sensitive Respiration in Mitochondria of Differentiated C2C12 Muscle Cells
Am J Physiol Cell Physiol. 2024 Apr 22. doi: 10.1152/ajpcell.00576.2023. Online ahead of print.ABSTRACTWe previously showed that the transaminase inhibitor, aminooxyacetic acid, reduced respiration energized at complex II (succinate dehydrogenase, SDH) in mitochondria isolated from mouse hindlimb muscle. The effect required a reduction in membrane potential with resultant accumulation of oxaloacetate (OAA), a potent inhibitor of SDH. To specifically assess the effect of the mitochondrial transaminase, glutamic oxaloacetic transaminase (GOT2) on complex II respiration and to determine the effect in intact cells as well as i...
Source: American Journal of Physiology. Cell Physiology - April 22, 2024 Category: Cytology Authors: Ritu Som Brian D Fink Liping Yu William I Sivitz Source Type: research
YiQi GuBen capsule alleviates OVA-induced asthma through improving mitochondrial dysfunction
Conclusion: This study suggests YiQi GuBen capsule can effectively improve mitochondrial dysfunction in the OVA-induced mouse model.PMID:38647486 | DOI:10.1080/02770903.2024.2303755 (Source: Journal of Asthma)
Source: Journal of Asthma - April 22, 2024 Category: Respiratory Medicine Authors: Xiaoting Ren Yibu Kong Hongjun Yu Aiai Dong Yongji Wang Lina Wei Yongfu Song Zhongtian Wang Lie Wang Yinan Guo Liping Sun Source Type: research
Genes, Vol. 15, Pages 523: Effects of Long-Term Cryopreservation on the Transcriptomes of Giant Grouper Sperm
This study provides rich data for studies of the mechanism underlying frozen fish sperm damage as well as a technical reference and evaluation index for the long-term cryopreservation of fish sperm. (Source: Genes)
Source: Genes - April 22, 2024 Category: Genetics & Stem Cells Authors: Xiaoyu Ding Yongsheng Tian Yishu Qiu Pengfei Duan Xinyi Wang Zhentong Li Linlin Li Yang Liu Linna Wang Tags: Article Source Type: research
Progress of Mitochondrial Function Regulation in Cardiac Regeneration
This article reviews mitochondria's multifaceted role in cardiac regeneration, particularly in myocardial infarction and heart failure models. Understanding mitochondrial function in cardiac regeneration aims to enhance myocardial infarction and heart failure treatment methods and insights.Graphical Abstract (Source: Journal of Cardiovascular Translational Research)
Source: Journal of Cardiovascular Translational Research - April 22, 2024 Category: Cardiology Source Type: research
Cardiomyocyte Adaptation to Exercise: K+ Channels,
Contractility and Ischemic Injury
Int J Sports Med DOI: 10.1055/a-2296-7604Cardiovascular disease is a leading cause of morbidity and mortality, and
exercise-training (TRN) is known to reduce risk factors and protect the heart
from ischemia and reperfusion injury. Though the cardioprotective effects of
exercise are well-documented, underlying mechanisms are not well understood.
This review highlights recent findings and focuses on cardiac factors with
emphasis on K+ channel control of the action potential duration
(APD), β-adrenergic and adenosine regulation of cardiomyocyte function, and
...
Source: International Journal of Sports Medicine - April 22, 2024 Category: Sports Medicine Authors: Fitts, Robert H. Wang, Xinrui Kwok, Wai-Meng Camara, Amadou K. S. Tags: Review Source Type: research
Evaluation of toxicity of thymoquinone, as a bioactive compound of nigella sativa using isolated mitochondria from different organs
. (Source: Toxin Reviews)
Source: Toxin Reviews - April 22, 2024 Category: Toxicology Authors: Ahmad SalimiSaleh KhezriKosar HelmiParya MalekiSeyyed Hossein Sajjadi AlehashemMilad Razmjoua Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iranb Traditional Medicine and Hydrotherapy Resea Source Type: research
Progress of Mitochondrial Function Regulation in Cardiac Regeneration
This article reviews mitochondria's multifaceted role in cardiac regeneration, particularly in myocardial infarction and heart failure models. Understanding mitochondrial function in cardiac regeneration aims to enhance myocardial infarction and heart failure treatment methods and insights.Graphical Abstract (Source: Journal of Cardiovascular Translational Research)
Source: Journal of Cardiovascular Translational Research - April 22, 2024 Category: Cardiology Source Type: research
Inhibition of Usp14 ameliorates renal ischemia-reperfusion injury by reducing Tfap2a stabilization and facilitating mitophagy
This study aimed to evaluate the impact of ubiquitin-specific peptidase 14 (Usp14), a deubiquitinase, in IR injury by influencing mitophagy. Utilizing a murine model of renal IR injury, Usp14 silencing was found to ameliorate kidney injury, leading to decreased levels of serum creatinine and blood urea nitrogen, alongside diminished oxidative stress and inflammation. In renal epithelial cells subjected to hypoxia/reoxygenation (H/R), Usp14 knockdown increased cell viability and reduced apoptosis. Further mechanistic studies revealed that Usp14 interacted with and deubiquitinated transcription factor AP-2 alpha (Tfap2a), th...
Source: Translational Research : the journal of laboratory and clinical medicine - April 21, 2024 Category: Laboratory Medicine Authors: Yang Li Boqing Dong Ying Wang Huanjing Bi Jing Zhang Chenguang Ding Chenge Wang Xiaoming Ding Wujun Xue Source Type: research
Aberrant expression of thyroidal hormone receptor α exasperating mitochondrial dysfunction induced sarcopenia in aged mice
In this study, decreased expression of myogenic regulators Myf5, MyoD1, mitophagy markers Pink1, LC3II/I, p62, as well as mitochondrial dynamic factors Mfn1 and Opa1, accompanied by increased reactive oxygen species (ROS), showed concomitant changes with reduced TRα expression in aged mice. Further TRα loss- and gain-of-function studies in C2C12 revealed that silencing of TRα not only down-regulated the expression of above-mentioned myogenic regulators, mitophagy markers and mitochondrial dynamic factors, but also led to a significant decrease in mitochondrial activity and maximum respiratory capacity, as well as more m...
Source: Aging - April 21, 2024 Category: Biomedical Science Authors: Yunlu Sheng Xiaoxia Zhu Lijun Wei Yuxin Zou Xinyu Qi Runqing Shi Wenli Xu Xiaodong Wang Guoxian Ding Yu Duan Source Type: research
Moringin, an isothiocyanate modulates multiple cellular signalling molecules in breast cancer cells
Cell Signal. 2024 Apr 19:111181. doi: 10.1016/j.cellsig.2024.111181. Online ahead of print.ABSTRACTProhibitin (PHB) is a pleiotropic molecule with a variety of known functions and subcellular locations. PHB's function in breast cancer is poorly understood. Herein, we report that PHB is expressed in cancer types of diverse origin including breast cancer. The cancer patients with changes in PHB were reported to have significantly reduced 'overall survival' in comparison to the cases without alterations in PHB. The expression of PHB was increased by H2O2 and also by Moringin (MG), which is an isothiocyanate derived from the s...
Source: Cellular Signalling - April 21, 2024 Category: Cytology Authors: Ankit Srivastava Shruti Mishra None Avadhesh Anusmita Shekher Vipin Rai Anupam Dhasmana Jayanta Das Daniele Perenzoni Renato Iori Subash C Gupta Source Type: research
Inhibition of Usp14 ameliorates renal ischemia-reperfusion injury by reducing Tfap2a stabilization and facilitating mitophagy
This study aimed to evaluate the impact of ubiquitin-specific peptidase 14 (Usp14), a deubiquitinase, in IR injury by influencing mitophagy. Utilizing a murine model of renal IR injury, Usp14 silencing was found to ameliorate kidney injury, leading to decreased levels of serum creatinine and blood urea nitrogen, alongside diminished oxidative stress and inflammation. In renal epithelial cells subjected to hypoxia/reoxygenation (H/R), Usp14 knockdown increased cell viability and reduced apoptosis. Further mechanistic studies revealed that Usp14 interacted with and deubiquitinated transcription factor AP-2 alpha (Tfap2a), th...
Source: Translational Research : the journal of laboratory and clinical medicine - April 21, 2024 Category: Laboratory Medicine Authors: Yang Li Boqing Dong Ying Wang Huanjing Bi Jing Zhang Chenguang Ding Chenge Wang Xiaoming Ding Wujun Xue Source Type: research
Mitophagy and its regulatory mechanisms in the biological effects of nanomaterials
AbstractMitophagy is a selective cellular process critical for the removal of damaged mitochondria. It is essential in regulating mitochondrial number, ensuring mitochondrial functionality, and maintaining cellular equilibrium, ultimately influencing cell destiny. Numerous pathologies, such as neurodegenerative diseases, cardiovascular disorders, cancers, and various other conditions, are associated with mitochondrial dysfunctions. Thus, a detailed exploration of the regulatory mechanisms of mitophagy is pivotal for enhancing our understanding and for the discovery of novel preventive and therapeutic options for these dise...
Source: Journal of Applied Toxicology - April 21, 2024 Category: Toxicology Authors: Rui Zhang,
Haitao Yang,
Menghao Guo,
Shuyan Niu,
Yuying Xue Tags: REVIEW ARTICLE Source Type: research
