HTD4010 attenuates myocardial injury in mice with septic cardiomyopathy by promoting autophagy < em > via < /em > the AMPK/mTOR signaling pathway
CONCLUSION: HTD4010 can attenuate myocardial injury in SCM mice possibly by promoting autophagy via modulating the AMPK/mTOR signaling pathway.PMID:38597442 | PMC:PMC11006686 | DOI:10.12122/j.issn.1673-4254.2024.03.12 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: H Xiao B Han J Guo C Wu J Wu Source Type: research
Development of Cu(II) 4-hydroxybenzoylhydrazone complexes that induce mitochondrial DNA damage and mitochondria-mediated apoptosis in liver cancer
In this study, two novel Cu(II) complexes (Cu1 and Cu2) were designed and synthesized. Notably, these Cu(II) complexes showed higher cytotoxicity against HL-7402 cells than cisplatin. Moreover, Cu(II) complexes significantly inhibited liver cancer growth in a xenograft model. A mechanism study revealed that the Cu(II) complexes reduced the mitochondrial membrane potential of cancer cells, produced excessive reactive oxygen species (ROS), induced mitochondrial DNA (mtDNA) damage, and ultimately facilitated cancer cell apoptosis.PMID:38599004 | DOI:10.1016/j.jinorgbio.2024.112550 (Source: Journal of Inorganic Biochemistry)
Source: Journal of Inorganic Biochemistry - April 10, 2024 Category: Biochemistry Authors: Ming Jiang Qiwei Yan Yuanping Fu Lili Meng Shuangshuang Gai Xiaohui Pan Yiming Qin Caiyun Jiang Source Type: research
A novel probe to monitor lysosome-mitochondria contact sites opens up a new path to study neurodegenerative diseases
Cell Calcium. 2024 Apr 8;120:102887. doi: 10.1016/j.ceca.2024.102887. Online ahead of print.NO ABSTRACTPMID:38599095 | DOI:10.1016/j.ceca.2024.102887 (Source: Cell Calcium)
Source: Cell Calcium - April 10, 2024 Category: Cytology Authors: Mai Makino Shuhei Nakamura Source Type: research
Alkaline sphingomyelinase deficiency impairs intestinal mucosal barrier integrity and reduces antioxidant capacity in dextran sulfate sodium-induced colitis
CONCLUSION: Alk-SMase regulates the stability of the intestinal mucosal barrier and enhances antioxidant activity through the Nrf2 signaling pathway.PMID:38596488 | PMC:PMC11000083 | DOI:10.3748/wjg.v30.i10.1405 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Ye Tian Xin Li Xu Wang Si-Ting Pei Hong-Xin Pan Yu-Qi Cheng Yi-Chen Li Wen-Ting Cao Jin-Dong Ding Petersen Ping Zhang Source Type: research
Alkaline sphingomyelinase deficiency impairs intestinal mucosal barrier integrity and reduces antioxidant capacity in dextran sulfate sodium-induced colitis
CONCLUSION: Alk-SMase regulates the stability of the intestinal mucosal barrier and enhances antioxidant activity through the Nrf2 signaling pathway.PMID:38596488 | PMC:PMC11000083 | DOI:10.3748/wjg.v30.i10.1405 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Ye Tian Xin Li Xu Wang Si-Ting Pei Hong-Xin Pan Yu-Qi Cheng Yi-Chen Li Wen-Ting Cao Jin-Dong Ding Petersen Ping Zhang Source Type: research
