pH regulating mechanisms of astrocytes: A critical component in physiology and disease of the brain
Cell Calcium. 2024 Apr 8;120:102882. doi: 10.1016/j.ceca.2024.102882. Online ahead of print.ABSTRACTStrict homeostatic control of pH in both intra- and extracellular compartments of the brain is fundamentally important, primarily due to the profound impact of free protons ([H+]) on neuronal activity and overall brain function. Astrocytes, crucial players in the homeostasis of various ions in the brain, actively regulate their intracellular [H+] (pHi) through multiple membrane transporters and carbonic anhydrases. The activation of astroglial pHi regulating mechanisms also leads to corresponding alterations in the acid-base...
Source: Cell Calcium - April 17, 2024 Category: Cytology Authors: Shefeeq M Theparambil Gulnaz Begum Christine R Rose Source Type: research
TRPM7 in neurodevelopment and therapeutic prospects for neurodegenerative disease
Cell Calcium. 2024 Apr 6;120:102886. doi: 10.1016/j.ceca.2024.102886. Online ahead of print.ABSTRACTNeurodevelopment, a complex and highly regulated process, plays a foundational role in shaping the structure and function of the nervous system. The transient receptor potential melastatin 7 (TRPM7), a divalent cation channel with an α-kinase domain, mediates a wide range of cellular functions, including proliferation, migration, cell adhesion, and survival, all of which are essential processes in neurodevelopment. The global knockout of either TRPM7 or TRPM7-kinase is embryonically lethal, highlighting the crucial role of ...
Source: Cell Calcium - April 17, 2024 Category: Cytology Authors: Zhengwei Luo Xinyang Zhang Andrea Fleig Daniel Romo Kenneth G Hull F David Horgen Hong-Shuo Sun Zhong-Ping Feng Source Type: research
A novel probe to monitor lysosome-mitochondria contact sites opens up a new path to study neurodegenerative diseases
Cell Calcium. 2024 Apr 8;120:102887. doi: 10.1016/j.ceca.2024.102887. Online ahead of print.NO ABSTRACTPMID:38599095 | DOI:10.1016/j.ceca.2024.102887 (Source: Cell Calcium)
Source: Cell Calcium - April 10, 2024 Category: Cytology Authors: Mai Makino Shuhei Nakamura Source Type: research
A novel probe to monitor lysosome-mitochondria contact sites opens up a new path to study neurodegenerative diseases
Cell Calcium. 2024 Apr 8;120:102887. doi: 10.1016/j.ceca.2024.102887. Online ahead of print.NO ABSTRACTPMID:38599095 | DOI:10.1016/j.ceca.2024.102887 (Source: Cell Calcium)
Source: Cell Calcium - April 10, 2024 Category: Cytology Authors: Mai Makino Shuhei Nakamura Source Type: research
A novel probe to monitor lysosome-mitochondria contact sites opens up a new path to study neurodegenerative diseases
Cell Calcium. 2024 Apr 8;120:102887. doi: 10.1016/j.ceca.2024.102887. Online ahead of print.NO ABSTRACTPMID:38599095 | DOI:10.1016/j.ceca.2024.102887 (Source: Cell Calcium)
Source: Cell Calcium - April 10, 2024 Category: Cytology Authors: Mai Makino Shuhei Nakamura Source Type: research
A novel probe to monitor lysosome-mitochondria contact sites opens up a new path to study neurodegenerative diseases
Cell Calcium. 2024 Apr 8;120:102887. doi: 10.1016/j.ceca.2024.102887. Online ahead of print.NO ABSTRACTPMID:38599095 | DOI:10.1016/j.ceca.2024.102887 (Source: Cell Calcium)
Source: Cell Calcium - April 10, 2024 Category: Cytology Authors: Mai Makino Shuhei Nakamura Source Type: research
A novel probe to monitor lysosome-mitochondria contact sites opens up a new path to study neurodegenerative diseases
Cell Calcium. 2024 Apr 8;120:102887. doi: 10.1016/j.ceca.2024.102887. Online ahead of print.NO ABSTRACTPMID:38599095 | DOI:10.1016/j.ceca.2024.102887 (Source: Cell Calcium)
Source: Cell Calcium - April 10, 2024 Category: Cytology Authors: Mai Makino Shuhei Nakamura Source Type: research
A novel probe to monitor lysosome-mitochondria contact sites opens up a new path to study neurodegenerative diseases
Cell Calcium. 2024 Apr 8;120:102887. doi: 10.1016/j.ceca.2024.102887. Online ahead of print.NO ABSTRACTPMID:38599095 | DOI:10.1016/j.ceca.2024.102887 (Source: Cell Calcium)
Source: Cell Calcium - April 10, 2024 Category: Cytology Authors: Mai Makino Shuhei Nakamura Source Type: research
PDX1, a transcription factor essential for organ differentiation, regulates SERCA-dependent Ca < sup > 2+ < /sup > homeostasis in sensory neurons
Cell Calcium. 2024 Apr 2;120:102884. doi: 10.1016/j.ceca.2024.102884. Online ahead of print.ABSTRACTPancreatic and duodenal homeobox 1 (PDX1) is a transcription factor required for the development and differentiation of the pancreas. Previous studies indicated that PDX1 expression was restricted to the gastrointestinal tract. Using a cre-dependent reporter, we observed PDX1-dependent expression of tdtomato (PDX1-tom) in a subpopulation of sensory nerves. Many of these PDX1-tom afferents expressed the neurofilament 200 protein and projected to the skin. Tdtomato-labeled terminals were associated with hair follicles in the f...
Source: Cell Calcium - April 4, 2024 Category: Cytology Authors: Jami L Saloman Ariel Y Epouhe Catherine F Ruff Kathryn M Albers Source Type: research
PDX1, a transcription factor essential for organ differentiation, regulates SERCA-dependent Ca < sup > 2+ < /sup > homeostasis in sensory neurons
Cell Calcium. 2024 Apr 2;120:102884. doi: 10.1016/j.ceca.2024.102884. Online ahead of print.ABSTRACTPancreatic and duodenal homeobox 1 (PDX1) is a transcription factor required for the development and differentiation of the pancreas. Previous studies indicated that PDX1 expression was restricted to the gastrointestinal tract. Using a cre-dependent reporter, we observed PDX1-dependent expression of tdtomato (PDX1-tom) in a subpopulation of sensory nerves. Many of these PDX1-tom afferents expressed the neurofilament 200 protein and projected to the skin. Tdtomato-labeled terminals were associated with hair follicles in the f...
Source: Cell Calcium - April 4, 2024 Category: Cytology Authors: Jami L Saloman Ariel Y Epouhe Catherine F Ruff Kathryn M Albers Source Type: research
PDX1, a transcription factor essential for organ differentiation, regulates SERCA-dependent Ca < sup > 2+ < /sup > homeostasis in sensory neurons
Cell Calcium. 2024 Apr 2;120:102884. doi: 10.1016/j.ceca.2024.102884. Online ahead of print.ABSTRACTPancreatic and duodenal homeobox 1 (PDX1) is a transcription factor required for the development and differentiation of the pancreas. Previous studies indicated that PDX1 expression was restricted to the gastrointestinal tract. Using a cre-dependent reporter, we observed PDX1-dependent expression of tdtomato (PDX1-tom) in a subpopulation of sensory nerves. Many of these PDX1-tom afferents expressed the neurofilament 200 protein and projected to the skin. Tdtomato-labeled terminals were associated with hair follicles in the f...
Source: Cell Calcium - April 4, 2024 Category: Cytology Authors: Jami L Saloman Ariel Y Epouhe Catherine F Ruff Kathryn M Albers Source Type: research
PDX1, a transcription factor essential for organ differentiation, regulates SERCA-dependent Ca < sup > 2+ < /sup > homeostasis in sensory neurons
Cell Calcium. 2024 Apr 2;120:102884. doi: 10.1016/j.ceca.2024.102884. Online ahead of print.ABSTRACTPancreatic and duodenal homeobox 1 (PDX1) is a transcription factor required for the development and differentiation of the pancreas. Previous studies indicated that PDX1 expression was restricted to the gastrointestinal tract. Using a cre-dependent reporter, we observed PDX1-dependent expression of tdtomato (PDX1-tom) in a subpopulation of sensory nerves. Many of these PDX1-tom afferents expressed the neurofilament 200 protein and projected to the skin. Tdtomato-labeled terminals were associated with hair follicles in the f...
Source: Cell Calcium - April 4, 2024 Category: Cytology Authors: Jami L Saloman Ariel Y Epouhe Catherine F Ruff Kathryn M Albers Source Type: research
PDX1, a transcription factor essential for organ differentiation, regulates SERCA-dependent Ca < sup > 2+ < /sup > homeostasis in sensory neurons
Cell Calcium. 2024 Apr 2;120:102884. doi: 10.1016/j.ceca.2024.102884. Online ahead of print.ABSTRACTPancreatic and duodenal homeobox 1 (PDX1) is a transcription factor required for the development and differentiation of the pancreas. Previous studies indicated that PDX1 expression was restricted to the gastrointestinal tract. Using a cre-dependent reporter, we observed PDX1-dependent expression of tdtomato (PDX1-tom) in a subpopulation of sensory nerves. Many of these PDX1-tom afferents expressed the neurofilament 200 protein and projected to the skin. Tdtomato-labeled terminals were associated with hair follicles in the f...
Source: Cell Calcium - April 4, 2024 Category: Cytology Authors: Jami L Saloman Ariel Y Epouhe Catherine F Ruff Kathryn M Albers Source Type: research
PDX1, a transcription factor essential for organ differentiation, regulates SERCA-dependent Ca < sup > 2+ < /sup > homeostasis in sensory neurons
Cell Calcium. 2024 Apr 2;120:102884. doi: 10.1016/j.ceca.2024.102884. Online ahead of print.ABSTRACTPancreatic and duodenal homeobox 1 (PDX1) is a transcription factor required for the development and differentiation of the pancreas. Previous studies indicated that PDX1 expression was restricted to the gastrointestinal tract. Using a cre-dependent reporter, we observed PDX1-dependent expression of tdtomato (PDX1-tom) in a subpopulation of sensory nerves. Many of these PDX1-tom afferents expressed the neurofilament 200 protein and projected to the skin. Tdtomato-labeled terminals were associated with hair follicles in the f...
Source: Cell Calcium - April 4, 2024 Category: Cytology Authors: Jami L Saloman Ariel Y Epouhe Catherine F Ruff Kathryn M Albers Source Type: research
Utilization of the genetically encoded calcium indicator Salsa6F in cardiac applications
Cell Calcium. 2024 May;119:102873. doi: 10.1016/j.ceca.2024.102873. Epub 2024 Mar 20.ABSTRACTCalcium signaling is a critical process required for cellular mechanisms such as cardiomyocyte contraction. The inability of the cell to properly activate or regulate calcium signaling can lead to contractile dysfunction. In isolated cardiomyocytes, calcium signaling has been primarily studied using calcium fluorescent dyes, however these dyes have limited applicability to whole organs. Here, we crossed the Salsa6f mouse which expresses a genetically encoded ratiometric cytosolic calcium indicator with a cardiomyocyte specific indu...
Source: Cell Calcium - March 27, 2024 Category: Cytology Authors: Karla M M árquez-Nogueras Elisa Bovo Jacy E Neczypor Quan Cao Aleksey V Zima Ivana Y Kuo Source Type: research
