[Fluoxetine enhances combined learning and memory abilities of mice by promoting neural cell functions in the barrel cortex].
Abstract OBJECTIVE: To study the behavioral characteristics of memory maintenance and regression in a mouse model of combined learning and memory training with fluoxetine treatment and explore the neural basis for learning and memory in the barrel area of the brain. METHODS: Twenty-six 16-day-old C57 mice were randomized into two equal groups and were given daily intraperitoneal injection of saline (control) or fluoxetine. The mice were subjected to stimulation of the right whiskers using a multi-sensory stimulation simulator and were given simultaneously olfactory stimulation with butyl acetate. In the initi...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Zhang T, Zhang W, Sun Y, Huo Q Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Effect of heat inactivation of blood samples on the efficacy of three detection methods of SARS-CoV-2 antibodies].
Abstract OBJECTIVE: To evaluate the effects of heat inactivation of blood samples at 56℃ for 30 min on the results of SARS-CoV-2 antibody detection using different methods. METHODS: This retrospective study was conducted in 11 patients with established diagnosis of COVID-19 and 10 patients with diseases other than COVID- 19 in our hospital. We collected samples of serum, plasma and whole blood from each patient between February, 12 and 18, 2020, and with a double- blind design, the samples were examined for SARS-CoV-2 antibodies before and after heat inactivation at 56 ℃ for 30 min. In all the samples, th...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Xue X, Zhu C, Huang S, Pan L, Xu J, Li W Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Accuracy of two thyroid imaging, reporting and data systems for differential diagnosis of benign and malignant thyroid nodules].
CONCLUSIONS: Both ACR TI-RADS and Kwak TI-RADS have good performance for differential diagnosis of thyroid nodules, but ACR TI-RADS has a higher specificity and a lower sensitivity compared with Kwak TI-RADS. PMID: 32376572 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Lai S, Chen Y, Chen Z, Wang L, Cong S, Kuang J Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Correlation between clinical classification of COVID-19 and imaging characteristics of MSCT volume scanning of the lungs].
Abstract OBJECTIVE: To investigate the correlation between the clinical classification of coronavirus disease 2019 (COVID-19) and the imaging characteristics of multislice spiral computed tomography (MSCT) volume scanning of the lungs. METHODS: The clinical data and thoracic MSCT volume scanning data were analyzed retrospectively for 102 patients with COVID-19 diagnosed and hospitalized in the First Affiliated Hospital of Bengbu Medical College between January 18 and February 26, 2020. According to the Fifth Edition of the Diagnosis and Treatment Guidelines by the National Health Commission, the patients were...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Guo F, Zhu L, Xu H, Qin L, Liang X, Deng X Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Pregnane X receptor promotes programmed cell death protein 4 expression in HepG2 cells].
CONCLUSIONS: Our findings demonstrate that PXR agonism in HepG2 cells increases the expression of PDCD4, which is independent of miRNA21 pathway, and PDCD4 may be a target gene of PXR in HepG2 cells. PMID: 32376574 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Wang S, Li T, Du J, Han M, Ju D Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Mechanism and surgical treatment of acetabular roof column fractures with external iliac arterial injury: analysis of 4 cases].
We report our experience with surgical treatment of 4 patients with acetabular roof column fracture and EIA injury. All the 4 patients underwent injury control resuscitation and surgery after admission. One patient died of multiple organ dysfunction syndrome (MODS), and the other 3 patients recovered smoothly. In these cases, as we presume, the occurrence of acetabular roof column fracture caused the EIA, which was connected to the iliopsoas muscle through soft tissues such as the iliac fascia, to be pulled into the fracture space along with the iliopsoas muscle and was cut directly by the fracture end; the EIA may also be...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Xu Y, Zhao M, Xiang J, Chen B Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Role of tumor necrosis factor- α in Chlamydia Muridarum infection in the urogenital tract of mice].
[Role of tumor necrosis factor-α in Chlamydia Muridarum infection in the urogenital tract of mice]. Nan Fang Yi Ke Da Xue Xue Bao. 2020 Mar 30;40(3):388-393 Authors: Chen X, Liu L, Zhang X, Lu C, Chen L, Quan S, Chen L Abstract OBJECTIVE: To explore the role of tumor necrosis factor-α (TNF-α) in immune response to urogenital chlamydial infection and urogenital pathology in mice. METHODS: Fifteen female wild-type (WT) C57BL/6J mice and 15 TNF-α receptor knockout (TNF-αR KO) mice were inoculated intravaginally with 1×104 inclusion forming units (IFUs) of live C. ...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Chen X, Liu L, Zhang X, Lu C, Chen L, Quan S, Chen L Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Treatment efficacy of Solitaire stent- and LVIS stent-assisted coil embolization for intracranial wide-neck carotid aneurysm].
CONCLUSIONS: Stent-assisted spring coils can achieve a high rate of complete and near-total embolization for intracranial aneurysms and is associated with a low incidence of neurological complications and favorable prognosis of the patients. The embolization rate, complications and recurrence rate are comparable between LVIS stent and Solitaire stent. PMID: 32376577 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Liu Y, Sun Y, He Y, Peng A, Yu Z, Lin Q, Zhang X Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Short-axis versus long-axis approach in ultrasound-guided central venous cannulation: an updated systematic review and meta-analysis].
CONCLUSIONS: Ultrasound-guided central venous cannulation via the SAX approach, as compared with the LAX approach, can increase first-attempt success rate and reduce the incidence of accidental arterial puncture. PMID: 32376578 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Yunyang H, Zaisheng Q, Nengxian S, Jin HE, Zhenhua Z Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Correlation between sarcopenia and albuminuria in patients with type 2 diabetes].
Abstract OBJECTIVE: To investigate the correlation between sarcopenia and albuminuria in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 360 T2DM patients (including 206 male and 154 female patients) hospitalized in our hospital between January, 2015 and December, 2018 were enrolled. According to their medical history and laboratory test results, the patients were divided into albuminuria group (n=122) and non-albuminuria group (n=238). The clinical and anthropological data were collected and skeletal muscle index (SMI), appendage lean mass, muscle index, total body fat, bone mineral capaci...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Yan J, Zheng K, Lin C, Liu C Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Psychological status and sleep quality of nursing interns during the outbreak of COVID-19].
Abstract OBJECTIVE: To investigate the psychological status and sleep quality of nursing interns in collective isolation during the outbreak of coronavirus disease 2019 (COVID-19) and provide evidence for adequate interventions. METHODS: We surveyed a total of 95 nursing interns who were isolated collectively in a general teaching hospital in Guangzhou using a self-designed questionnaire, which consisted of a basic information form, self-rating anxiety scale (SAS), self-rating depression scale (SDS) and Pittsburgh Sleep Quality Index (PSQI). Descriptive analysis, single factor analysis and correlation analysi...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Sheng X, Liu F, Zhou J, Liao R Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[An increased neutrophil/lymphocyte ratio is an early warning signal of severe COVID-19].
Abstract OBJECTIVE: To identify the biomarkers as early warning signals for severe COVID-19. METHODS: We retrospectively analyzed the clinical data of 63 patients with COVID- 19 from Hubei Provincial Hospital of Integrated Chinese and Western Medicine, including 32 moderate cases and 31 severe cases. The demographic data, underlying diseases, clinical manifestations and laboratory test results were compared between the two groups. Logistic regression analysis was performed to identify the factors that predicted the severity of COVID-19. The receiver- operating characteristic curve (ROC) of neutrophil/lymphocy...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Xia X, Wen M, Zhan S, He J, Chen W Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Serum annexin A2 level is significantly elevated in patients with coronary heart disease].
Abstract OBJECTIVE: To analyze the correlation of annexin A2 with coronary atherosclerotic heart disease (CAD) and the severity of CAD. METHODS: We collected data from a total of 200 inpatients admitted in our department between August, 2017 and August, 2019. According to the. RESULTS: of coronary angiography, the patients were divided into CAD group (n=150) and non-CAD (n=50), and the CAD patients was further divided, according to their clinical stability, into stable angina (SAP) group and acute coronary syndrome (ACS) group. Serum levels of annexin A2, MPO and PON1 were detected in all these patients,...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Lin Z, Liu D, Xue Y, Wu T, Zeng X, Guo Z, Cao S Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Diagnosis and treatment of an elderly patient with secondary cerebral infarction caused by COVID-19].
Abstract We review the experience with the diagnosis and treatment of secondary cerebral infarction in an elderly patient with coronavirus disease 2019 (COVID-19). COVID-19 has rapid disease progression with a high mortality rate in elderly patients, and physicians should be alert to secondary bacterial infection that may result in coagulation dysfunction and cerebral infarction. Early anti-infection therapy, immune regulation and appropriate anticoagulation intervention may help improve the prognosis of the patients. PMID: 32376583 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: He J, Cheng G, Xu W, Zhang L, Zeng Z Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Chloroquine enhances cisplatin-induced apoptosis of nasopharyngeal carcinoma cells by inhibiting autophagy via upregulating miR129].
Abstract OBJECTIVE: To investigate the role of miR129 in mediating the effect of chloroquine to enhance cisplatin- induced apoptosis in nasopharyngeal carcinoma cells (HNE1). METHODS: MTT assay was used to detect the viability of HNE1 cells treated with different concentrations of cisplatin. Colony formation of HNE1 cells treated with cisplatin and chloroquine, alone or in combination, was observed using crystal violet staining. BALB/C unde mice were inoculated with HNE1 cells and randomly divided into 4 groups with 6 mice in each group. The mice received intraperitoneal injections of cisplatin and chloroquin...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Zhang H, Yu Y, Cai W, Lu H, He R, Zhang R, Pei F, Wang X, Fang Y, Wei F Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[T1-weighted magnetic resonance imaging contrast agents and their theranostic nanoprobes].
Abstract Magnetic resonance imaging (MRI) is an important imaging modality for clinical disease diagnosis, and nearly 50% of clinical MRI examinations require contrast agents to enhance the diagnostic sensitivity. This review provides a summary of the major MRI contrast agents and their classification, and the advantages and limits of the commercially available MRI contrast agents, and elaborates on the exceedingly small magnetic iron oxide nanoparticles (ES-MIONs), dotted core-shell iron and gadolinium hybrid nanoparticles (FeGd-HN) and exceedingly small gadolinium oxide nanoparticles (ES-GON). These nanoparticle...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Zhou H, Qiu X, Shen Z Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Application of self-propelled micro-/nanomotors in active targeted drug delivery].
Abstract As a new type of micro-/nanomachines, self-propelled micro-/nanomotors (MNMs) can convert chemical or external energies from the surrounding environment into mechanical forces to produce autonomous motion. The ability of autonomous movement allows these MNMs to move actively to the targeted locations, and thus confers great potentials on the MNMs for applications in biomedicine, especially in drug delivery. MNMs have been shown to effectively load therapeutic payloads for active delivery to the disease site, which greatly improves the therapeutic efficacy and reduces side effects compared with the traditi...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Liu M, Tu B, Liu L, Chen B, Tu Y Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Conducting clinical studies during the epidemics of communicable diseases: perspectives of methodology and health economics].
Abstract In the setting of epidemics of communicable diseases, early initiation of epidemiological and clinical data collection and analysis and conducting relevant researches are essential to the success of epidemic containment. The coronavirus disease 2019 (COVID-19), starting initially as an epidemic in China in late 2019 and now becoming a pandemic globally, poses grave challenges to the global health care systems while also provides an opportunity for studying infectious diseases in the perspective of methodology. The authors propose the evaluation methods for case reports, randomized controlled trials (RCTs)...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Gong M, Liu L, Wu C, Yang Y, Shen Y, Li J, Lin K, Guo Y, Wei H, Xu Z, Zhu H Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Supporting the battle against COVID-19 in E'zhou, Hubei Province: the experience of Guizhou medical team].
o S Abstract To suppress the rapid spread of coronavirus disease 2019 (COVID-19) in Hubei province, a medical rescue team consisting of 860 members was sent to E'zhou, one of the hard-hit cities in east Hubei. A total of 414 of the team members, whose core members were from Guizhou Medical University and its Affiliated Hospital, took over the full operation of Leishan hospital of E'zhou, a makeshift hospital built for treating COVID-19 patients. Under the instructions by the E'zhou Medical Team Front Command, the staff made quick responses to the surging number of patients with COVID-19 and rapidly formulated trea...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Zhang T, Ran L, Li K, Liu J, Chen L, Lü J, Liang G, Zuo S Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Chest CT findings and their dynamic changes in patients with COVID-19].
Abstract ObjectiveTo define chest CT findings and their dynamic changes in patients with coronavirus disease 2019 (COVID-19) from disease onset to the cure.MethodWe analyzed the clinical and chest CT data of 6 patients with RT-PCR-confirmed COVID-19. According to the time from the disease onset to the cure or from the onset to each CT scan, the total of 30 chest CT scans were divided into 4 stages, namely stage 1 (0-4 days), stage 2 (5-9 days), stage 3 (10-14 days), and stage 4 (over 14 days). A semi-quantitative scoring system was used to quantitatively assess the pulmonary involvement on the basis of the involve...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Xiang Y, Yang Q, Sun H, Qin X, Li X, Zhang Q Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Phagocytosis of alveolar macrophages is suppressed in a mouse model of lipopolysaccharide-induced acute lung injury].
Abstract OBJECTIVE: To investigate the changes in phagocytic function of alveolar macrophages (AMs) in mice with lipopolysaccharide (LPS)-induced acute lung injury (ALI) and explore the possible mechanism. METHODS: Kunming mice were randomly divided into normal control group and ALI (induced by LPS instillation in the airway) model group. AMs were obtained from bronchoalveolar lavage fluid in both groups, and phagocytosis of the AMs was observed using flow cytometry and fluorescence microscopy. Western blotting and ELISA were used to detect the expression and secretion of IL-33 in the lung tissue of the mice....
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Yang Q, Gao P, Mu M, Tao X, He J, Wu F, Guo S, Qian Z, Song C Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Risk factors for nausea and vomiting after adolescent idiopathic scoliosis surgery].
Abstract OBJECTIVE: To explore risk factors for postoperative nausea and vomiting (PONV) that requires intervention with medications during adolescent idiopathic scoliosis (AIS) surgery. METHODS: We analyzed the data of 986 patients with AIS (including 156 male and 830 female patients) undergoing scoliosis surgery through a posterior approach between December, 2012 and January, 2016 in Nanjing Drum Tower Hospital. The data were collected from the patients including ASA grade, body mass index (BMI), Cobb angle, preoperative respiratory and cardiovascular diseases, operation time, type of anesthesia, quantity o...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Feng D, Jia R, Ma Z, Gu X Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Tracheal intubation in patients with severe and critical COVID-19: analysis of 18 cases].
Abstract OBJECTIVE: To analyze the clinical characteristics of patients with severe or critical coronavirus disease 2019 (COVID-19) receiving tracheal intubation. METHODS: We analyzed clinical characteristics of 18 severely or critically ill patients with COVID-19 undergoing tracheal intubation. The general demographic and clinical data of the patients including their age, gender, pre- intubation state of consciousness and the ventilation mode were recorded. The anesthesiologists performing the tracheal intubation procedure evaluated and recorded the tracheal intubation conditions of the patients. The changes...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Wang J, Lu F, Zhou M, Qi Z, Chen Z Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Liquid chromatography tandem mass spectrometry for therapeutic drug monitoring of voriconazole in heat-inactivated blood samples: its application during COVID-19 pandemic].
CONCLUSIONS: Heat inactivation at 56 ℃ for 30 min combined with ethanol sample preparation only has limited effects to affect LC-MS-based voriconazole concentration measurement in whole blood samples collected in heparinized tubes, and can be used for therapeutic drug monitoring of voriconazole during the ongoing COVID-19 pandemic. PMID: 32376593 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Zhao B, Liu S, Liu Y, Li G, Zhang Q Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Clinical practice guidelines for precision diagnosis and treatment of complex liver tumor guided by three-dimensional visualization technology (version 2019)].
Abstract Virtual resection of liver structures guided by three-dimensional visualization technology (3DVT) has been extensively used in China. This technique provides a safe and effective method for accurate diagnosis of liver tumors and has important applications in preoperative evaluation, surgical planning and intraoperative guidance of liver cancer surgeries. The technical advantages and clinical significance of 3DVT in the diagnosis and treatment of complex liver tumors have been recognized. In order to standardize the application of 3DVT in the precision diagnosis and treatment of complex liver tumors, this ...
Source: Journal of Southern Medical University - March 30, 2020 Category: Universities & Medical Training Authors: Chinese SODM, Liver CCOCMDA, Clinical PMCOCMDA, Digital ISCOCRHA Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Expression of kinesin KIF3A in the kidney of mice with unilateral ureteral obstruction].
Abstract OBJECTIVE: To investigate the expression of KIF3A in mice with unilateral ureteral obstruction (UUO) and TGF-β1-induced NRK-52E cells and the role of KIF3A in renal tubular epithelial cell transdifferentiation. METHODS: Thirty-six C57BL/6J mice were randomly divided into the sham group (n=18) and UUO group (n=18). Six mice in each group were sacrificed at 7, 14 and 21days after the operation. The degree of renal tubulointerstitial fibrosis of the mice was observed by HE staining, Masson trichrome staining and Sirius red staining. The expression and distribution of KIF3A in the kidney of the mice...
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Gu W, Pan W, Zhu Q, Xiao X, Zhao Y, Liu Y, Liu J, Li M Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Detection rate of thyroid nodules in routine health check-up and its influencing factors: a 10-year survey of 309 576 cases].
Abstract OBJECTIVE: To analyze the detection rate of thyroid nodules and its influencing factors among individuals undergoing routine health check-up in Guangdong Province. METHODS: We analyzed the results of thyroid ultrasonography of 309 576 individuals receiving routine health check-up in a general hospital in Guangdong Province over the past 10 years. The data were compared between the individuals with and without thyroid nodules using two independent samples t test, MannWhitney U test and Chi-square test. Binary logistic regression was used to analyze the relationship between different factors and thyroi...
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Lai X, Ouyang P, Zhu H, An S, Xia L, Yao Y, Zhang H, Li Z, Deng K Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Prognostic significance and risk factors of minimal residual disease ≥1% on 19th day of induction chemotherapy in children with acute lymphoblastic leukemia].
[Prognostic significance and risk factors of minimal residual disease ≥1% on 19th day of induction chemotherapy in children with acute lymphoblastic leukemia]. Nan Fang Yi Ke Da Xue Xue Bao. 2020 Feb 29;40(2):255-261 Authors: Yu J, Yi T, Lin G, Wen J, Chen L, Chen J, Wu X Abstract OBJECTIVE: To assess the prognostic value of minimal residual disease on 19th day of induction chemotherapy (D19 MRD) and the risk factors of D19 MRD ≥ 1% in children with acute lymphoblastic leukemia (ALL) treated following the Chinese Children's Cancer Group ALL protocol. METHODS: We retrospectively analyzed the...
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Yu J, Yi T, Lin G, Wen J, Chen L, Chen J, Wu X Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[The postbiotic HM0539 from Lactobacillus rhamnosus GG prevents intestinal infection by enterohemorrhagic E. coli O157: H7 in mice].
Abstract OBJECTIVE: To assess the protective effect of the novel postbiotic HM0539 from Lactobacillus rhamnosus GG against intestinal infection by enterohemorrhagic E. coli O157: H7. METHODS: We performed adhesion and invasion experiments to evaluate whether HM0539 could block E. coli O157: H7 adhesion to HT-29 cells. The expressions of mucin2 and the tight junction proteins ZO-1 and Occludin in HM0539-treated HT-29 cells were analyzed using immunofluorescence assay and Western blotting. Animal experiments were conducted in mice to observe the survival rate and changes in body weight, intestinal morphology an...
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Zhang H, Gao J, He X, Gong Z, Wan Y, Hu T, Li Y, Cao H Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Mental health status and its influencing factors among college students during the epidemic of COVID-19].
CONCLUSIONS: The college students have different levels of anxiety and depression during the epidemic. Depression and anxiety are closely related, but the factors contributing to different levels of such emotions can be different, and colleges and related departments are urged to provide precision mental health education for college students. PMID: 32376528 [PubMed - indexed for MEDLINE] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Chang J, Yuan Y, Wang D Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[HPLC using capillary monolithic column molecularly imprinted with composite metal organic frame for enrichment and detection of Ponceau 4R in Carthami flos].
CONCLUSIONS: The UiO-66-NH2@MIPs column-HPLC system has much better performance for enrichment, purification and detection of Ponceau 4R in Carthami flos than direct HPLC. PMID: 32376529 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Ning C, Li R, Chen L, Jin T, Qiu J, Liu Z, Su Z, Lin J Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Effects of olfactory deprivation on action potential and ankyrin-G expression in glutamatergic neurons in the barrel cortex of mice].
Abstract OBJECTIVE: To investigate effect of upregulated touch sensation induced by olfactory deprivation on action potentials and ankyrin-G expression in the glutamatergic neurons in the barrel cortex of mice. METHODS: Chloroform (40 μL) was dropped into the unilateral nasal cavity to induce olfactory deprivation in 40 C57 mice (12 days old), whose glutamatergic neurons were genetically labeled with yellow fluorescent protein (YFP). Behavioral experiments were carried out to assess the effects of olfactory deprivation on whisker tactile of the mice. The action potentials of the glutamatergic neurons in th...
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Ni H, Ding H, Tao J, Wang Y, Tao M, Huang L Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Management and prevention of common skin problems during epidemic prevention and control of COVID-19].
Abstract In the ongoing fight against the epidemic of COVID-19, the medical staff has been under tremendous pressure. Wearing the protective equipment (masks, goggles, and protective screens) with a poor breathability for a long time causes various skin problems, such as allergies, excessive skin hydration, local mechanical injuries, and even secondary infections. In addition, in a closed environment, compression and friction aggravate skin reactions, which may compromise duty performance of the medical staff. It is therefore essential to provide timely treatment opinions and prevention methods for common skin pro...
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Li C, Shen J, Ju Y, Huang X, Huang L, Zeng K Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Consensus of Chinese experts on diagnosis and treatment processes of acute myocardial infarction in the context of prevention and control of COVID-19 (first edition)].
, Zhang G, Zhang R, Zhang S, Zhang Y, Zhang Z, Zheng B, Zhou N Abstract The SARS-CoV-2 epidemic starting in Wuhan in December, 2019 has spread rapidly throughout the nation. The control measures to contain the epidemic also produced influences on the transport and treatment process of patients with acute myocardial infarction (AMI), and adjustments in the management of the patients need to be made at this particular time. AMI is characterized by an acute onset with potentially fatal consequence, a short optimal treatment window, and frequent complications including respiratory infections and respiratory and circul...
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Bu J, Chen M, Cheng X, Dong Y, Fang W, Ge J, Gong Y, He B, Huang L, Huo Y, Jia S, Jiang J, Li Y, Li Z, Liang C, Liu X, Liu Z, Ma X, Ma Y, Qian J, Shen C, Shen D, Shen L, Shi R, Su X, Sun Y, Tang Y, Wang J, Wu Y, Xiang D, Xu T, Xu Y, Yang Y, Zeng H, Zhang Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Mechanism of Jiawei Huangqin decoction for treating ulcerative colitis in mice: the role of STAT3/NF-kB/IL-6 pathway].
Abstract OBJECTIVE: To investigate the therapeutic effect of Jiawei Huangqin (JWHQ) decoction on ulcerative colitis (UC) and the regulation of STAT3/NF-kB/IL-6 pathway. METHODS: Forty-eight mice were randomized into blank control group, model group, positive control (Sulfasalazine) group, and low-, moderate- and high-dose JWHQ Decoction groups (n=8). In all but the blank control groups, the mice were given 3% DSS in drinking water to induce UC, followed 7 days later by treatment with saline (blank control and model groups) or JWHQ Decoction by gavage (10 mL/k) for 7 consecutive days. After the treatment, the ...
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Wang K, Miao Z, Dong Y, Ye B Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Deep learning network-based recognition and localization of diatom images against complex background].
ConclusionThe proposed method can be applied for recognition and location of diatom targets against complex background interference in autopsy. PMID: 32376534 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Deng J, He D, Zhuo J, Zhao J, Xiao C, Kang X, Hu S, Gu G, Liu C Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Analysis of variation and evolution of SARS-CoV-2 genome].
CONCLUSIONS: SARS-CoV-2 may have emerged as early as November, 2019, originating most likely from bat-associated coronavirus. This finding may provide evidence for tracing the sources and evolution of the virus. PMID: 32376535 [PubMed - indexed for MEDLINE] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Zhou Y, Zhang S, Chen J, Wan C, Zhao W, Zhang B Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Anti-CD206 antibody-conjugated Fe3O4-based PLGA nanoparticles selectively promotes M1 polarization of tumorassociated macrophages in mice].
Abstract OBJECTIVE: To enhance the anti-tumor immunity of macrophages by increasing iron concentration in the macrophages using nanospheres. METHODS: Anti-CD206 antibody-conjugated Fe3O4-based polylactic acid glycolic acid (CD206- Fe3O4-PLGA) nanoparticles were prepared with the W/O/W method. The particle diameter was measured using Malvern particle size detector, the Zeta potential was determined using Zeta potentiometry, and the encapsulation efficiency of Fe3O4 was determined using an iron determination kit. The macrophage-binding and targeting abilities of the conjugated nanoparticles were evaluated using...
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Fu Q, Tang H, Zhang P, Que K, Liu Z, Zhou Y Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Hydrogen water alleviates paraquat-induced lung fibroblast injury in vitro by enhancing Nrf2 expression].
CONCLUSIONS: Hydrogen water enhances Nrf2 expression to promote the proliferation and production of antioxidants and inhibit the differentiation and collagen secretion in PQ-exposed human lung fibroblasts in vitro. PMID: 32376537 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Li T, Deng S, Lei W, Li Z, Wu W, Zhang T, Dong Z Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Artificial intelligence empowers laboratory medicine in Industry 4.0].
Abstract Since 2017, China, the United States, and the European Union have successively issued national-level artificial intelligence (AI) strategic development plans, and the human history is about to witness the 4th industrial revolution with the theme of "intelligence". In the field of medical testing, the explosive growth of AI theories and technologies also provide a new direction for the development of medical testing theory, methods and applications. We review the evolution of AI and the recent progress in three major elements of AI, namely algorithms, data and computing power, and elaborate on th...
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Zhou Q, Qi S, Xiao B, Li Q, Sun Z, Li L Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Toxicity of dibutyl phthalate in primary cultured rat hippocampal neurons and the toxicological mechanism].
Abstract OBJECTIVE: To investigate the neurotoxicity and toxicological mechanism of dibutyl phthalate (DBP) in primary cultured rat hippocampal neurons. METHODS: Primary rat hippocampal neurons cultured for 4 days were exposed to 1 g/L DBP for 24, 48, or 96 h. Immunofluorescence assay and transmission electron microscopy (TEM) were used to observe the morphological changes of the axons and the ultrastructure of DBP-treated neurons. The action potential (AP) of the hippocampal neurons was measured with patch-clamp electrophysiology. CCK-8 assay was used to detect the viability of the hippocampal neurons, and W...
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Li Y, Li X, Xie M, Cheng L, Chen H, Sun H, Jiang L Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[The value of cytochrome P4502C19 gene assay for anti-platelet therapy after PCI in stable angina patients with left main coronary artery lesions].
CONCLUSIONS: For stable angina patients with complicated left main coronary artery lesions and intermediate metabolizer CYP2C19 gene, aspirin combined with ticagrelor antiplatelet therapy after PCI is effective, the effect of ticagrelor is better than clopidogrel on MACE, and ticagrelor does not seem to increase the risk of bleeding. PMID: 32376540 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Zheng X, Wu L Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Progress in extracellular vesicle imaging methods].
Abstract Extracellular vesicles (EVs), including exosomes and microvesicles, are lipid bilayer-enclosed nanovesicles secreted by cells. These EVs are important mediators of intercellular communication by serving as vehicles for transfer of proteins, mRNA, miRNA and lipids between cells. Various visualization methods have been established to explore the characteristics of EVs and their role in physiological and pathological processes. The nanoscale size and high heterogeneity of EVs hamper the identification of their biological characteristics and functions. This review presents a comprehensive overview of EV imagi...
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Wang K, Wei Y, Zhang P, Wang J, Hu J, Wang L, Li B Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Harmless acute pancreatitis score on admission can accurately predict mild acute pancreatitis].
Abstract OBJECTIVE: To evaluate the efficacy of harmless acute pancreatitis score (HAPS) on admission for predicting mild acute pancreatitis (MAP). METHODS: We prospectively collected the data from consecutive AP patients admitted to West China Hospital between January, 2016 and August, 2017, and HAPS scores were calculated on admission. The clinical outcomes of the patients with harmless AP (HAPS>2) and those with non-harmless AP (HAPS≤2) were compared. MAP was defined based on the severity classification of 2012 Revised Atlanta guidelines. The area under the curve (AUC) of the receiver- operator chara...
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Ma X, Li L, Jin T, Xia Q Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Dandelion clock-like sign on CT for diagnose of COVID-19].
CONCLUSIONS: The dandelion clock-like sign is a common and characteristic chest CT finding in patients with SARS-CoV-2-associated pneumonia, and can help to distinguish SARS-CoV-2-associated pneumonia from other types of pneumonia. PMID: 32376543 [PubMed - indexed for MEDLINE] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Fu X, Li J, Huang Z, Xu Z, Yao W, Cui Y, Ouyang K, Liu H Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Peripheral blood albumin level in significantly correlated with the severity of atherosclerosis in hypertensive patients].
Abstract OBJECTIVE: To investigate the relationship between peripheral blood albumin (Hb) level and the severity of arteriosclerosis in hypertensive patients. METHODS: This retrospective analysis was conducted among 419 randomly selected patients with hypertension. The pulse wave velocity (ba-PWV) of the bilateral limbs was measured using an arteriosclerosis tester. According to the ba-PWV value (the higher value of the two sides), the hypertensive patients were divided into 4 groups, namely normal arterial group [S0 group, ba-PWV 2 000 cm/s; 111 cases (26.5 %)]. The clinical data of the patients were collect...
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Huang J, Ma J, Guo Y, Wang Y, Zhang Q, Zhong J, Jiang W, Li Y, Xu L Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Lung sounds can be used as an indicator for assessing severity of chronic obstructive pulmonary disease at the initial diagnosis].
Abstract OBJECTIVE: To assess the value of pulmonary auscultation for evaluating the severity of chronic obstructive pulmonary disease (COPD) at the initial diagnosis. METHODS: The patients with newly diagnosed COPD in our hospital between May, 2016 and May, 2019 were enrolled in this study. According to the findings of pulmonary auscultation, the lung sounds were classified into 5 groups: normal breathing sounds, weakened breathing sounds, weakened breathing sounds with wheezing, obviously weakened breathing sounds, and obviously weakened breathing sounds with wheezing. The pulmonary function of the patients...
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Chen S, Huang M, Peng X, Yuan Y, Huang S, Ye Y, Zhao W, Li B, Han H, Yang S, Cai S, Zhao H Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Laboratory testing techniques for SARS-CoV-2].
Abstract The ongoing epidemic of caused by the coronavirus SARS-CoV-2 starting in December 2019 poses a serious public health threat globally. The virus is highly infectious and transmitted mainly through droplets and contacts, and is associated with a high risk of pneumonia. A small number of patients may present with acute respiratory distress syndrome with severe respiratory complications, which can lead even to death. The selection of appropriate detection techniques and methods for accurate and rapid identification of pathogens therefore plays a key role in improving the diagnosis and treatment of the patient...
Source: Journal of Southern Medical University - February 29, 2020 Category: Universities & Medical Training Authors: Qiu F, Wang H, Zhang Z, Cao L, Wang C, Wu J, Du Q Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Application and research progress of internet-based cognitive behavioral therapy for insomnia disorder].
Abstract Insomnia disorder is one of the most common sleep disorders with an increasing incidence to cause substantial economic losses and social burden. The therapy for insomnia disorder mainly includes medication treatment and cognitive behavioral therapy. Medications are associated with various adverse effects and can be easily addictive. Cognitive behavioral therapy has been proposed as the first-line treatment for insomnia disorder. But due to the disadvantages of face-to-face cognitive behavioral therapy including a high cost and the lack of standardization, internet-based cognitive behavioral therapy has em...
Source: Journal of Southern Medical University - January 30, 2020 Category: Universities & Medical Training Authors: Yang L, Kang Y, Zhang W, Zhang B Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

[Recombinant methioninase regulates PI3K/Akt/Glut-1 pathway and inhibits aerobic glycolysis to promote apoptosis of gastric cancer cells].
Abstract OBJECTIVE: To investigate the molecular mechanism of recombinant methioninase (rMETase) in promoting apoptosis of gastric cancer cells. METHODS: Gastric cancer SGC-7901 cells were treated with rMETase (final concentration of 1.25 and 2.50 mmmol/L) for 72 h, and the changes in the cell viability were detected using CCK-8 method and the cell morphology changes were observed under an inverted microscope. Plate colony formation assay was used to evaluate colony formation ability of the cells, and flow cytometry was performed to analyze the changes in cell apoptosis and cell cycles. Glucose and lactate le...
Source: Journal of Southern Medical University - January 30, 2020 Category: Universities & Medical Training Authors: Zhou L, Li S, Liu L, Zhou Q, Yuan Y, Xin L Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research