Spaced training activates Miro/Milton-dependent mitochondrial dynamics in neuronal axons to sustain long-term memory
Curr Biol. 2024 Apr 17:S0960-9822(24)00390-7. doi: 10.1016/j.cub.2024.03.050. Online ahead of print.ABSTRACTNeurons have differential and fluctuating energy needs across distinct cellular compartments, shaped by brain electrochemical activity associated with cognition. In vitro studies show that mitochondria transport from soma to axons is key to maintaining neuronal energy homeostasis. Nevertheless, whether the spatial distribution of neuronal mitochondria is dynamically adjusted in vivo in an experience-dependent manner remains unknown. In Drosophila, associative long-term memory (LTM) formation is initiated by an early ...
Source: Current Biology - April 20, 2024 Category: Biology Authors: Alice Pavlowsky Typhaine Comyn Julia Minatchy David Geny Philippe Bun Lydia Danglot Thomas Preat Pierre-Yves Pla çais Source Type: research
Dimorphic effect of TFE3 in determining mitochondrial and lysosomal content in muscle following denervation
Muscle atrophy is a common consequence of the loss of innervation and is accompanied by mitochondrial dysfunction. Mitophagy is the adaptive process through which damaged mitochondria are removed via the lysos... (Source: Skeletal Muscle)
Source: Skeletal Muscle - April 20, 2024 Category: Research Authors: Ashley N. Oliveira, Jonathan M. Memme, Jenna Wong and David A. Hood Tags: Research Source Type: research
High glucose-induced p66Shc mitochondrial translocation regulates autophagy initiation and autophagosome formation in syncytiotrophoblast and extravillous trophoblast
p66Shc, as a redox enzyme, regulates reactive oxygen species (ROS) production in mitochondria and autophagy. However, the mechanisms by which p66Shc affects autophagosome formation are not fully understood. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 20, 2024 Category: Molecular Biology Authors: Lulu Ji, Xiaoli Zhang, Zhiguo Chen, Yuexiao Wang, Hengxuan Zhu, Yaru Nai, Yanyi Huang, Rujie Lai, Yu Zhong, Xiting Yang, Qiongtao Wang, Hanyang Hu and Lin Wang Tags: Research Source Type: research
Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension
CONCLUSIONS: These data support the pathogenic role of CypD acetylation in endothelial dysfunction and hypertension. We suggest that targeting cytotoxic mitochondrial isolevuglandins and GCN5L1 reduces CypD acetylation, which may be beneficial in cardiovascular disease.PMID:38639088 | DOI:10.1161/CIRCRESAHA.123.323596 (Source: Circulation Research)
Source: Circulation Research - April 19, 2024 Category: Cardiology Authors: Anna Dikalova Daniel Fehrenbach Vladimir Mayorov Alexander Panov Mingfang Ao Louise Lantier Venkataraman Amarnath Marcos G Lopez Frederic T Billings Iv Michael N Sack Sergey Dikalov Source Type: research
TPP-based conjugates: potential targeting ligands
Drug Discov Today. 2024 Apr 17:103983. doi: 10.1016/j.drudis.2024.103983. Online ahead of print.ABSTRACTMitochondria are one of the major sources of energy for, as well as regulators of, cancer cell metabolism. Thus, they are potential targets for the effective treatment and management of cancer. Research has explored triphenylphosphonium (TPP) derivatives as potent cancer-targeting ligands because of their lipophilic nature and mitochondrial affinity. In this review, we summarize the utility of TPP-based conjugates targeting mitochondria in different types of cancer and other diseases, such as neurodegenerative and cardio...
Source: Drug Discovery Today - April 19, 2024 Category: Drugs & Pharmacology Authors: Sanya Batheja Shruti Gupta Kiran Kumar Tejavath Umesh Gupta Source Type: research
DNA repair deficiencies and neurodegeneration
DNA Repair (Amst). 2024 Apr 16;138:103679. doi: 10.1016/j.dnarep.2024.103679. Online ahead of print.ABSTRACTNeurodegenerative diseases are the second most prevalent cause of death in industrialized countries. Alzheimer's Disease is the most widespread and also most acknowledged form of dementia today. Together with Parkinson's Disease they account for over 90 % cases of neurodegenerative disorders caused by proteopathies. Far less known are the neurodegenerative pathologies in DNA repair deficiency syndromes. Such diseases like Cockayne - or Werner Syndrome are described as progeroid syndromes - diseases that cause the pre...
Source: DNA Repair - April 19, 2024 Category: Genetics & Stem Cells Authors: Baptiste Ropert Christian Gallrein Bj örn Schumacher Source Type: research
Proteomic Profiling of Antimalarial Plasmodione Using 3-Benz(o)ylmenadione Affinity-Based Probes
Chembiochem. 2024 Apr 19:e202400187. doi: 10.1002/cbic.202400187. Online ahead of print.ABSTRACTUnderstanding the mechanisms of drug action in malarial parasites is crucial for the development of new drugs to combat infection and to counteract drug resistance. Proteomics is a widely used approach to study host-pathogen systems and to identify drug protein targets. Plasmodione is an antiplasmodial early-lead drug exerting potent activities against young asexual and sexual blood stages in vitro with low toxicity to host cells. To elucidate its molecular mechanisms, an affinity-based protein profiling (AfBPP) approach was app...
Source: Chembiochem - April 19, 2024 Category: Biochemistry Authors: Ilaria Iacobucci Vittoria Monaco Agn ès Hovasse Baptiste Dupouy Rodrigue Keumoe Bogdan Cichocki Mourad Elhabiri Brigitte Meunier Jean-Marc Strub Maria Monti Sarah Cianf érani St éphanie A Blandin Christine Schaeffer-Reiss Elisabeth Davioud-Charvet Source Type: research
Mitochondria function in cytoplasmic FeS protein biogenesis
Biochim Biophys Acta Mol Cell Res. 2024 Apr 17:119733. doi: 10.1016/j.bbamcr.2024.119733. Online ahead of print.ABSTRACTIron‑sulfur (FeS) clusters are cofactors of numerous proteins involved in various essential functions including cellular respiration, protein translation, DNA synthesis and repair, ribosome maturation, anti-viral responses, and isopropylmalate isomerase activity. Novel FeS cluster proteins are still being discovered due to the widespread use of cryogenic electron microscopy (cryo-EM) and elegant genetic screens targeted at protein discovery. A complex sequence of biochemical reactions mediated by a cons...
Source: Biochimica et Biophysica Acta - April 19, 2024 Category: Biochemistry Authors: Andrew Dancis Ashutosh K Pandey Debkumar Pain Source Type: research
Evaluation of histological and ultrastructural changes provoked by prenatal tramadol on postnatal cortical cerebellar neuronal development in rats: possible implication of Ki67, GFAP and MicroRNA-7/P53 signalling trajectories
J Mol Histol. 2024 Apr 19. doi: 10.1007/s10735-024-10189-2. Online ahead of print.ABSTRACTTramadol is a novel centrally acting analgesic. Despite, its implementation during pregnancy may impair neuronal survival and synaptic development in neonatal cerebella. The current investigation assessed the histological and ultrastructural alterations in postnatal cortical cerebellar neuronal development induced by prenatal tramadol. 30 offsprings were divided to control group I: fifteen pups born to mothers given saline from D10 till D21 of gestation. Tramadol-treated group II: fifteen pups born to mothers received tramadol HCL (50...
Source: Molecular Medicine - April 19, 2024 Category: Molecular Biology Authors: Walaa Adel Abdelmoez Source Type: research
Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension
CONCLUSIONS: These data support the pathogenic role of CypD acetylation in endothelial dysfunction and hypertension. We suggest that targeting cytotoxic mitochondrial isolevuglandins and GCN5L1 reduces CypD acetylation, which may be beneficial in cardiovascular disease.PMID:38639088 | DOI:10.1161/CIRCRESAHA.123.323596 (Source: Circulation Research)
Source: Circulation Research - April 19, 2024 Category: Cardiology Authors: Anna Dikalova Daniel Fehrenbach Vladimir Mayorov Alexander Panov Mingfang Ao Louise Lantier Venkataraman Amarnath Marcos G Lopez Frederic T Billings Iv Michael N Sack Sergey Dikalov Source Type: research
DNA repair deficiencies and neurodegeneration
DNA Repair (Amst). 2024 Apr 16;138:103679. doi: 10.1016/j.dnarep.2024.103679. Online ahead of print.ABSTRACTNeurodegenerative diseases are the second most prevalent cause of death in industrialized countries. Alzheimer's Disease is the most widespread and also most acknowledged form of dementia today. Together with Parkinson's Disease they account for over 90 % cases of neurodegenerative disorders caused by proteopathies. Far less known are the neurodegenerative pathologies in DNA repair deficiency syndromes. Such diseases like Cockayne - or Werner Syndrome are described as progeroid syndromes - diseases that cause the pre...
Source: DNA Repair - April 19, 2024 Category: Genetics & Stem Cells Authors: Baptiste Ropert Christian Gallrein Bj örn Schumacher Source Type: research
DNA repair deficiencies and neurodegeneration
DNA Repair (Amst). 2024 Apr 16;138:103679. doi: 10.1016/j.dnarep.2024.103679. Online ahead of print.ABSTRACTNeurodegenerative diseases are the second most prevalent cause of death in industrialized countries. Alzheimer's Disease is the most widespread and also most acknowledged form of dementia today. Together with Parkinson's Disease they account for over 90 % cases of neurodegenerative disorders caused by proteopathies. Far less known are the neurodegenerative pathologies in DNA repair deficiency syndromes. Such diseases like Cockayne - or Werner Syndrome are described as progeroid syndromes - diseases that cause the pre...
Source: DNA Repair - April 19, 2024 Category: Genetics & Stem Cells Authors: Baptiste Ropert Christian Gallrein Bj örn Schumacher Source Type: research
Evaluation of histological and ultrastructural changes provoked by prenatal tramadol on postnatal cortical cerebellar neuronal development in rats: possible implication of Ki67, GFAP and MicroRNA-7/P53 signalling trajectories
AbstractTramadol is a novel centrally acting analgesic. Despite, its implementation during pregnancy may impair neuronal survival and synaptic development in neonatal cerebella. The current investigation assessed the histological and ultrastructural alterations in postnatal cortical cerebellar neuronal development induced by prenatal tramadol. 30 offsprings were divided tocontrol group I: fifteen pups born to mothers given saline from D10 till D21 of gestation.Tramadol-treated group II: fifteen pups born to mothers received tramadol HCL (50 mg/kg/day) from D10 till D21 of gestation. Pups were categorized into three subgr...
Source: Journal of Molecular Histology - April 19, 2024 Category: Laboratory Medicine Source Type: research
Mitochondria protective and anti-apoptotic effects of peripheral benzodiazepine receptor and its ligands on the treatment of asthma in vitro and vivo
Asthma is a prevalent respiratory inflammatory disease. Abnormal apoptosis of bronchial epithelial cells is one of the major factors in the progression of asthma. Peripheral benzodiazepine receptors are highly... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 19, 2024 Category: Allergy & Immunology Authors: Yurui Liu, Zhengze Zhang, Yuewen He, Ruogen Li, Yuhao Zhang, Hao Liu, Yong Wang and Wuhua Ma Tags: Research Source Type: research
TBBPS caused necroptosis and inflammation in hepatocytes by blocking PINK1-PARKIN-mediated mitochondrial autophagy
Tissue Cell. 2024 Apr 10;88:102382. doi: 10.1016/j.tice.2024.102382. Online ahead of print.ABSTRACTThe widespread use of Tetrabromobisphenol S (TBBPS), as an alternative to tetrabromobisphenol A (TBBPA), has been detected at high frequency in environmental media in recent years, TBBPS can enter the body via the digestive tract and other routes, thus long-term TBBPS exposure may cause adverse health effects. Therefore, it is necessary to evaluate the toxicological effects of TBBPS. In the current work, two cell models of the liver were used (a human-derived cell line THLE-2 and a murine-derived AML12). The liver cells were ...
Source: Tissue and Cell - April 18, 2024 Category: Cytology Authors: Yujun Yin Minshi Huang Jianlong Xie Yongfang Ou Tianfu Mai Source Type: research
