Liraglutide exhibits anti-inflammatory activity through the activation of the PKA/CREB pathway
Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their f... (Source: Journal of Inflammation)
Source: Journal of Inflammation - October 11, 2019 Category: Allergy & Immunology Authors: Li Wang, Linjie Feng and Jingyu Zhang Tags: Commentary Source Type: research

Structural and functional abnormalities of penile cavernous endothelial cells result in erectile dysfunction at experimental autoimmune prostatitis rat
There is growing recognition of the association of CP/CPPS accompany with ED. However, the specific mechanism of action remains unclear. The aim of this study was to investigate structural and functional abnor... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 25, 2019 Category: Allergy & Immunology Authors: Tianrun Huang, Guangchun Wang, Yangyang Hu, Heng Shi, Keyi Wang, Lei Yin and Bo Peng Tags: Research Source Type: research

IL-35 alleviates inflammation progression in a rat model of diabetic neuropathic pain via inhibition of JNK signaling
Emerging evidence has demonstrated that inflammation is involved in the occurrence and development of diabetic neuropathic pain (DNP). The anti-inflammatory property of interleukin (IL)-35 makes it a promising... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 23, 2019 Category: Allergy & Immunology Authors: Yinghai Jiang, Jing Wang, Haiqin Li and Lingjie Xia Tags: Research Source Type: research

The in vitro Mycobacterium bovis BCG Moreau infection of human monocytes that induces Caspase-1 expression, release and dependent cell death is mostly reliant upon cell integrity
Caused by Mycobacterium tuberculosis, tuberculosis (TB) is an extremely contagious disease predominantly affecting the lungs. TB is found worldwide and has a major impact on public health safety primarily due to ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 15, 2019 Category: Allergy & Immunology Authors: Paulo R. Z. Antas, Carlos G. G. Ponte, Matheus R. Almeida, Lawrence H. P. Albuquerque, Periela S. Sousa-Vasconcelos, Tha íze Pedro, Natália L. S. Gomes, Otacílio C. Moreira, Fernanda C. Silva, Luíz R. R. Castello-Branco and Rosa T. Pinho Tags: Research Source Type: research

Deficiency of fibroblast growth factor 21 aggravates obesity-induced atrophic responses in skeletal muscle
Obesity-induced skeletal muscle inflammation is a major contributor of skeletal muscle loss/atrophy and is implicated in metabolic complications such as insulin resistance. Fibroblast growth factor 21 (FGF21) ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 4, 2019 Category: Allergy & Immunology Authors: Chu-Sook Kim, Yeonsoo Joe, Hye-Seon Choi, Sung Hoon Back, Jeong Woo Park, Hun Taeg Chung, Eun Roh, Min-Seon Kim, Tae Youl Ha and Rina Yu Tags: Research Source Type: research

Hypertonic solution-induced preconditioning reduces inflammation and mortality rate
Dysregulated inflammatory response is common cause of organ damage in critical care patients. Preconditioning/tolerance is a strategy to prevent exacerbated inflammation. The aim of this study is to analyze hy... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 3, 2019 Category: Allergy & Immunology Authors: Rosangela Nascimento Pimentel, Ricardo Costa Petroni, Hermes Vieira Barbeiro, Denise Frediani Barbeiro, Mariana Macedo Andrade, Suely Kumini Ariga and Francisco Garcia Soriano Tags: Research Source Type: research

“In sickness and in health” – how neutrophil extracellular trap (NET) works in infections, selected diseases and pregnancy
The discovery of the NET network (neutrophil extracellular trap) has revolutionized the perception of defense mechanisms used by neutrophils in infections and non-infectious states, as this mechanism proves th... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 28, 2019 Category: Allergy & Immunology Authors: Paulina Nied źwiedzka-Rystwej, Weronika Repka, Beata Tokarz-Deptuła and Wiesław Deptuła Tags: Review Source Type: research

High-fat diet-induced obesity causes an inflammatory microenvironment in the kidneys of aging Long-Evans rats
Obesity is a risk factor for chronic kidney disease (CKD). While the exact mechanisms remain unclear, inflammation may be a consequence of obesity that directly impacts the kidneys. The aim of this study was t... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 25, 2019 Category: Allergy & Immunology Authors: Thea Laurentius, Ute Raffetseder, Claudia Fellner, Robert Kob, Mahtab Nourbakhsh, J ürgen Floege, Thomas Bertsch, Leo Cornelius Bollheimer and Tammo Ostendorf Tags: Research Source Type: research

The GLP-1 agonist, liraglutide, ameliorates inflammation through the activation of the PKA/CREB pathway in a rat model of knee osteoarthritis
Inflammation is a common pathological phenomenon of osteoarthritis (OA). Accumulated evidence indicates that ameliorating or suppressing inflammation might be a promising and effective therapeutic strategy for... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 6, 2019 Category: Allergy & Immunology Authors: Qihong Que, Xinghua Guo, Longxin Zhan, Shaodong Chen, Zengli Zhang, Xiaoming Ni, Bin Ye and Shuanglin Wan Tags: Research Source Type: research

Ferroptosis inhibitor alleviates Radiation-induced lung fibrosis (RILF) via down-regulation of TGF- β1
Radiation-induced lung fibrosis (RILF) is a severe and life-threatening complication of thoracic radiotherapy. Cell death is the key issue in RILF. Ferroptosis is a form programmed cell death implicated in the... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 29, 2019 Category: Allergy & Immunology Authors: Xuan Li, Lijie Duan, Sujuan Yuan, Xibing Zhuang, Tiankui Qiao and Jian He Tags: Research Source Type: research

Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice
Ischemia-reperfusion injury (IRI) is an antigen-independent, innate immune response to arterial occlusion and ischemia with subsequent paradoxical exacerbation after reperfusion. IRI remains a critical problem... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 29, 2019 Category: Allergy & Immunology Authors: Jordan R. Yaron, Hao Chen, Sriram Ambadapadi, Liqiang Zhang, Amanda M. Tafoya, Barbara H. Munk, Dara N. Wakefield, Jorge Fuentes, Bruno J. Marques, Krishna Harripersaud, Mee Yong Bartee, Jennifer A. Davids, Donghang Zheng, Kenneth Rand, Lisa Dixon, Richar Tags: Short Report Source Type: research

Evidence for the important role of inflammation in xenotransplantation
There is increasing evidence of a sustained state of systemic inflammation after pig-to-nonhuman primate (NHP) xenotransplantation (that has been termed systemic inflammation in xenograft recipients [SIXR]). I... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 28, 2019 Category: Allergy & Immunology Authors: Juan Li, Hidetaka Hara, Yi Wang, Charles Esmon, David K. C. Cooper and Hayato Iwase Tags: Review Source Type: research

Anti-vascular endothelial growth factor agent reduces inflammation in macular edema with central retinal vein occlusion
Correlations among the aqueous flare value (an indicator of inflammation), functional-morphologic parameters, and aqueous humor levels of growth factors/receptors and inflammatory factors/cytokines were invest... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 22, 2019 Category: Allergy & Immunology Authors: Asako Mashima, Hidetaka Noma, Kanako Yasuda, Hiroshi Goto and Masahiko Shimura Tags: Research Source Type: research

Role of autophagy in atherosclerosis: foe or friend?
Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular walls. Different mechanisms and pathological features are evident at the onset of atherosclerotic changes via the enga... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 2, 2019 Category: Allergy & Immunology Authors: Mehdi Hassanpour, Reza Rahbarghazi, Mohammad Nouri, Nasser Aghamohammadzadeh, Nasser Safaei and Mahdi Ahmadi Tags: Review Source Type: research

Accumulation of free cholesterol and oxidized low-density lipoprotein is associated with portal inflammation and fibrosis in nonalcoholic fatty liver disease
Macrophages engulf oxidized-LDL (oxLDL) leading to accumulation of cellular cholesterol and formation of foam cells, which is a hallmark of atherosclerosis. Moreover, recent studies showed that accumulation of... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 2, 2019 Category: Allergy & Immunology Authors: Cheng-Maw Ho, Shu-Li Ho, Yung-Ming Jeng, Yu-Sheng Lai, Ya-Hui Chen, Shao-Chun Lu, Hui-Ling Chen, Po-Yuan Chang, Rey-Heng Hu and Po-Huang Lee Tags: Research Source Type: research

Decrease in inflammatory biomarker concentration by intervention with selenium and coenzyme Q10: a subanalysis of osteopontin, osteoprotergerin, TNFr1, TNFr2 and TWEAK
Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiovascular mortality, and increase cardiac function in elderly persons ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 18, 2019 Category: Allergy & Immunology Authors: Urban Alehagen, Jan Alexander, Jan Aaseth and Anders Larsson Tags: Research Source Type: research

SNP variations in IL10, TNF α and TNFAIP3 genes in patients with dry eye syndrome and Sjogren’s syndrome
In this study we compared single nucleotide polymorphism (SNP) variations in genes encoding cytokine le... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 18, 2019 Category: Allergy & Immunology Authors: Hadas Ben-Eli, Nir Gomel, Doron Jacob Aframian, Rania Abu-Seir, Riki Perlman, Eldad Ben-Chetrit, dror Mevorach, Geffen Kleinstern, Ora Paltiel and Abraham Solomon Tags: Research Source Type: research

Extracellular acidification-induced CXCL8 production through a proton-sensing receptor OGR1 in human airway smooth muscle cells: a response inhibited by dexamethasone
Human airway smooth muscle cells (ASMCs) contribute to bronchial contraction and airway hyperresponsiveness in patients with bronchial asthma. They also generate cytokines, chemokines, and matricellular protei... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 19, 2019 Category: Allergy & Immunology Authors: Maiko Kadowaki, Hidenori Yamada, Koichi Sato, Hiroko Shigemi, Yukihiro Umeda, Miwa Morikawa, Yuko Waseda, Masaki Anzai, Yosuke Kamide, Haruka Aoki-Saito, Takeshi Hisada, Fumikazu Okajima and Tamotsu Ishizuka Tags: Research Source Type: research

LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture
Sepsis is a systemic inflammatory response syndrome caused by severe infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory function against sepsis. Micro- and macro-circ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 18, 2019 Category: Allergy & Immunology Authors: Weiwei Ge, Qiaohua Hu, Xiangshao Fang, Juanhua Liu, Jing Xu, Juntao Hu, Xuefen Liu, Qin Ling, Yue Wang, He Li, Ming Gao, Longyuan Jiang, Zhengfei Yang and Wanchun Tang Tags: Research Source Type: research

Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis
In order to gain insight into the early effects drawn by JAK inhibitors on intra-joint JAK/STAT-dependent signaling, we sought synovial activation of STATs and their end-products, along with their modification... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 29, 2019 Category: Allergy & Immunology Authors: Sandra P érez-Baos, Paula Gratal, Juan I. Barrasa, Ana Lamuedra, Olga Sánchez-Pernaute, Gabriel Herrero-Beaumont and Raquel Largo Tags: Research Source Type: research

Biomarkers for Acute Respiratory Distress syndrome and prospects for personalised medicine
Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute respiratory distress syndrome (ARDS) being the most severe form of ALI and having a mortality rate in the region o... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 15, 2019 Category: Allergy & Immunology Authors: Savino Spadaro, Mirae Park, Cecilia Turrini, Tanushree Tunstall, Ryan Thwaites, Tommaso Mauri, Riccardo Ragazzi, Paolo Ruggeri, Trevor T. Hansel, Gaetano Caramori and Carlo Alberto Volta Tags: Review Source Type: research

The role of N-glycosylation of CD200-CD200R1 interaction in classical microglial activation
Microglial inflammatory activation is the common feature of the central nervous system (CNS) diseases. Microglia can be activated and particularly polarized toward a dual role in the injured CNS. The CD200 rec... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 19, 2018 Category: Allergy & Immunology Authors: Chao Liu, Yifen Shen, Ying Tang and Yongchun Gu Tags: Research Source Type: research

Transient receptor potential ankyrin 1 (trpa1) mediates il-1 β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction
Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger. ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 17, 2018 Category: Allergy & Immunology Authors: Songjiang Yin, Li Zhang, Liang Ding, Zhengquan Huang, Bo Xu, XiaoChen Li, Peimin Wang and Jun Mao Tags: Research Source Type: research

Dynamics of soluble vascular endothelial growth factor receptors and their ligands in aqueous humour during ranibizumab for age-related macular degeneration
Intravitreal ranibizumab injection (IRI) is effective for patients with exudative age-related macular degeneration (AMD) and decreases intraocular levels of vascular endothelial growth factor (VEGF), but VEGF ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 4, 2018 Category: Allergy & Immunology Authors: Ryosuke Motohashi, Hidetaka Noma, Kanako Yasuda, Osamu Kotake, Hiroshi Goto and Masahiko Shimura Tags: Research Source Type: research

Cannabinoid 2 receptor attenuates inflammation during skin wound healing by inhibiting M1 macrophages rather than activating M2 macrophages
The anti-inflammatory properties of the cannabinoid 2 receptor (CB2R) in injury and inflammatory diseases have been widely substantiated. Specifically, the anti-inflammatory effect of CB2R may be achieved by r... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 4, 2018 Category: Allergy & Immunology Authors: Yu Du, Peng Ren, Qi Wang, Shu-Kun Jiang, Miao Zhang, Jiao-Yong Li, Lin-Lin Wang and Da-Wei Guan Tags: Research Source Type: research

Suppression of hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia following systemic administration of lutein via inhibition of cyclooxygenase-2 cascade signaling
Lutein is a dietary constituent known to inhibit inflammation; however, its effect on nociceptive neuron-associated hyperalgesia remains to be determined. The present study therefore investigated under in vivo... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 26, 2018 Category: Allergy & Immunology Authors: Yumiko Syoji, Ryota Kobayashi, Nako Miyamura, Tsukasa Hirohara, Yoshiko Kubota, Nobuo Uotsu, Kei Yui, Yoshihito Shimazu and Mamoru Takeda Tags: Research Source Type: research

Circulating natural antibodies to inflammatory cytokines are potential biomarkers for atherosclerosis
Inflammatory cytokines contribute to the development of atherosclerosis. Natural antibodies in the circulation have protective effects on common diseases including atherosclerosis-related conditions. (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 16, 2018 Category: Allergy & Immunology Authors: Peng Wang, Huan Zhao, Zhenqi Wang and Xuan Zhang Tags: Research Source Type: research

Contribution of the inflammasome to inflammaging
Inflammation is a natural part of the aging process. This process is referred to as inflammaging. Inflammaging has been associated with deleterious outcomes in the aging brain in diseases such as Alzheimer ’s d... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 16, 2018 Category: Allergy & Immunology Authors: Nancy H. Mejias, Camila C. Martinez, Marisa E. Stephens and Juan Pablo de Rivero Vaccari Tags: Research Source Type: research

The severity of LPS induced inflammatory injury is negatively associated with the functional liver mass after LPS injection in rat model
High levels of serum lipopolysaccharide (LPS) were observed in sepsis patients with liver injury and high mortality. However, the role of liver in modulation LPS induced inflammatory injury was ill investigate... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 15, 2018 Category: Allergy & Immunology Authors: Haoshu Fang, Anding Liu, Xulin Chen, Wenhui Cheng, Olaf Dirsch and Uta Dahmen Tags: Research Source Type: research

ZNF580 – a brake on Interleukin-6
Zinc finger protein 580 (ZNF580) was reported to modulate angiogenesis, endothelial homeostasis and blood pressure control. ZNF580 regulated genes include VEGF-A and IL-8. However, it is unknown if ZNF580 coul... (Source: Journal of Inflammation)
Source: Journal of Inflammation - October 22, 2018 Category: Allergy & Immunology Authors: Philipp Stenzel, Kaj Nagorsen, Jonathan Bernd, Ulrike Leppert, Andreas Zakrzewicz and Janine Berkholz Tags: Research Source Type: research

The roles of IL-19 and IL-20 in the inflammation of degenerative lumbar spondylolisthesis
Degenerative lumbar spondylolisthesis (DLS) is a major cause of spinal canal stenosis and is often related to lower back pain. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokin... (Source: Journal of Inflammation)
Source: Journal of Inflammation - September 18, 2018 Category: Allergy & Immunology Authors: Kuo-Yuan Huang, Yu-Hsiang Hsu, Wei-Yu Chen, Hui-Ling Tsai, Jing-Jou Yan, Jung-Der Wang, Wen-Lung Liu and Ruey-Mo Lin Tags: Research Source Type: research

Contribution of diminished kidney transplant GFR to increased circulating chemokine ligand 27 level
Inflammatory chemokine ligands (CCLs) play an important role in cardiovascular disease and allograft injury. CCLs may independently associate with diminished estimated glomerular filtration rate (eGFR) in stab... (Source: Journal of Inflammation)
Source: Journal of Inflammation - September 10, 2018 Category: Allergy & Immunology Authors: Ahmed Zahran, Ahmed Attia, Holly Mansell and Ahmed Shoker Tags: Research Source Type: research

In vitro suppression of inflammatory cytokine response by methionine sulfoximine
The glutamine synthetase inhibitor methionine sulfoximine (MSO), shown previously to prevent death caused by an inflammatory liver response in mice, was tested on in vitro production of cytokines by mouse peri... (Source: Journal of Inflammation)
Source: Journal of Inflammation - September 10, 2018 Category: Allergy & Immunology Authors: Tyler J. Peters, Amruta A. Jambekar and William S. A. Brusilow Tags: Research Source Type: research

Expression and clinical significance of the NEK7-NLRP3 inflammasome signaling pathway in patients with systemic lupus erythematosus
The aim of the study was to investigate the expression of the NEK7-NLRP3 inflammasome signaling pathway in the peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE), as... (Source: Journal of Inflammation)
Source: Journal of Inflammation - September 3, 2018 Category: Allergy & Immunology Authors: Zhen-Zhen Ma, Hong-Sheng Sun, Ji-Cai Lv, Lei Guo and Qing-Rui Yang Tags: Research Source Type: research

MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1 α
T helper 17 (Th17) cells have proven to be crucial in the pathogenesis of neutrophils-dominant asthma. Hypoxia inducible factor-1 α (HIF-1α) is involved in allergic responses in asthma. Our previous studies ind... (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 20, 2018 Category: Allergy & Immunology Authors: Li Xu, Wen J. Sun, Ai J. Jia, Lu L. Qiu, Bing Xiao, Lin Mu, Jian M. Li, Xiu F. Zhang, Yan Wei, Cong Peng, Dong S. Zhang and Xu D. Xiang Tags: Research Source Type: research

Anti-inflammatory effect of hesperidin enhances chondrogenesis of human mesenchymal stem cells for cartilage tissue repair
Articular cartilage diseases are considered a major health problem, and tissue engineering using human mesenchymal stem cells (MSCs) have been shown as a promising solution for cartilage tissue repair. Hesperi... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 20, 2018 Category: Allergy & Immunology Authors: Shipeng Xiao, Wenguang Liu, Jianqiang Bi, Shenghou Liu, Heng Zhao, Ningji Gong, Deguo Xing, Hongwei Gao and Mingzhi Gong Tags: Research Source Type: research

Caspase recruitment domain (CARD) family (CARD9, CARD10, CARD11, CARD14 and CARD15) are increased during active inflammation in patients with inflammatory bowel disease
The CARD family plays an important role in innate immune response by the activation of NF- κB. The aim of this study was to determine the gene expression and to enumerate the protein-expressing cells of some me... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 11, 2018 Category: Allergy & Immunology Authors: Jes ús K. Yamamoto-Furusho, Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Andrea Sarmiento-Aguilar, Rafael Barreto-Zuñiga, Braulio Martínez-Benitez and Montserrat A. Lara-Velazquez Tags: Research Source Type: research

Experimental murine acute lung injury induces increase of pulmonary TIE2-expressing macrophages
Breakdown of the alveolo-capillary wall is pathognomonic for Acute Lung Injury (ALI). Angiopoietins, vascular-specific growth factors, are linked to endothelial barrier dysfunction, and elevated Angiopoietin-2... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 14, 2018 Category: Allergy & Immunology Authors: Heidi Ehrentraut, Christina Weisheit, Marcel Scheck, Stilla Frede and Tobias Hilbert Tags: Research Source Type: research

The impact of septic stimuli on the systemic inflammatory response and physiologic insult in a preclinical non-human primate model of polytraumatic injury
Established animal trauma models are limited in recapitulating the pathophysiology of human traumatic injury. Herein, we characterize the physiologic insult and inflammatory response in two clinically relevant... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 24, 2018 Category: Allergy & Immunology Authors: Diego A. Vicente, Matthew J. Bradley, Benjamin Bograd, Crystal Leonhardt, Eric A. Elster and Thomas A. Davis Tags: Research Source Type: research

CXCR-4 expression by circulating endothelial progenitor cells and SDF-1 serum levels are elevated in septic patients
In this study, we investigated, whether surface expression of chemokine receptors and other receptors imp... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 16, 2018 Category: Allergy & Immunology Authors: Christian Patry, Daniela Stamm, Christian Betzen, Burkhard T önshoff, Benito A. Yard, Grietje Ch. Beck and Neysan Rafat Tags: Research Source Type: research

Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis
Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. T... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 9, 2018 Category: Allergy & Immunology Authors: K. L. C. da Silva, A. P. Camacho, F. C. Mittestainer, B. M. Carvalho, A. Santos, D. Guadagnini, A. G. Oliveira and M. J. A. Saad Tags: Research Source Type: research

The role of adipokines in skeletal muscle inflammation and insulin sensitivity
There is currently an unmet clinical need to develop better pharmacological treatments to improve glucose handling in Type II Diabetes patients with obesity. To this end, determining the effect of obesity-asso... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 9, 2018 Category: Allergy & Immunology Authors: Thomas Nicholson, Chris Church, David J. Baker and Simon W. Jones Tags: Review Source Type: research

Functional role of microRNA-135a in colitis
Inflammatory bowel disease (IBD) is one of the chronic gastrointestinal diseases with increasing risk of colon cancer development in the future. Apoptosis and inflammation play an important role in the etiolog... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 6, 2018 Category: Allergy & Immunology Authors: Chunyan Lou and Yanyang Li Tags: Research Source Type: research

Correction to: Knockdown of miR-155 protects microglia against LPS-induced inflammatory injury via targeting RACK1: a novel research for intracranial infection
Upon publication of the original article [1] it was highlighted by the authors that the first affiliation of author Haiyan Yin was incorrectly cited in duplicate as “Department of Neurology, Affiliated Hospita... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 3, 2018 Category: Allergy & Immunology Authors: Haiyan Yin, Shuwen Song and Xudong Pan Tags: Correction Source Type: research

Zymosan attenuates melanoma growth progression, increases splenocyte proliferation and induces TLR-2/4 and TNF- α expression in mice
Melanoma is one of the most common types of skin malignancies. Since current therapies are suboptimal, considerable interest has focused on novel natural-based treatments. Toll-like receptors (TLRs) play an im... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 22, 2018 Category: Allergy & Immunology Authors: Mehdi Taghavi, Esmaeil Mortaz, Alireza Khosravi, Ghasem Vahedi, Gert Folkerts, Mohammad Varahram, Mehdi Kazempour-Dizaji, Johan Garssen and Ian M. Adcock Tags: Research Source Type: research

Interleukin-10 attenuates impairment of the blood-brain barrier in a severe acute pancreatitis rat model
Impairment of the blood-brain barrier (BBB) in severe acute pancreatitis (SAP) could result in life-threatening pancreatic encephalopathy. Interleukin-10 (IL-10) is a classical cytokine that is well-known for ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 27, 2018 Category: Allergy & Immunology Authors: Ronggui Lin, Fei Chen, Shi Wen, Tianhong Teng, Yu Pan and Heguang Huang Tags: Research Source Type: research

Histone deacetylase 2 (HDAC2) attenuates lipopolysaccharide (LPS)-induced inflammation by regulating PAI-1 expression
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection, and is primarily characterized by an uncontrolled systemic inflammatory response. In the present study, we deve... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 10, 2018 Category: Allergy & Immunology Authors: Wen-Feng Fang, Yu-Mu Chen, Chiung-Yu Lin, Hui-Lin Huang, Hua Yeh, Ya-Ting Chang, Kuo-Tung Huang and Meng-Chih Lin Tags: Research Source Type: research

Plasma vascular non-inflammatory molecule 3 is associated with gastrointestinal acute graft-versus-host disease in mice
Gastrointestinal acute graft-versus-host disease (GI aGVHD) is a lethal complication following allogeneic hematopoietic stem cell transplantation (HSCT). However, it is still very difficult to make a diagnosis... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 5, 2018 Category: Allergy & Immunology Authors: Na Wang, Xiaoyi Qin, Yigeng Cao, Bin Liang, Kang Yu and Haige Ye Tags: Research Source Type: research

Anti-inflammatory cellular targets on neutrophils elucidated using a novel cell migration model and confocal microscopy: a clinical supplementation study
In vivo studies have shown grape seed-derived polyphenols (GSP) to benefit in recovery from muscle injury by modulation of neutrophil infiltration into damaged tissue, thereby reducing secondary damage, as wel... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 5, 2018 Category: Allergy & Immunology Authors: T. Smith, L. Engelbrecht and C. Smith Tags: Research Source Type: research

Neutrophil extracellular traps and the dysfunctional innate immune response of cystic fibrosis lung disease: a review
Cystic Fibrosis (CF) is a devastating genetic disease characterised primarily by unrelenting lung inflammation and infection resulting in premature death and significant morbidity. Neutrophil Extracellular Tra... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 28, 2017 Category: Allergy & Immunology Authors: Sheonagh M. Law and Robert D. Gray Tags: Review Source Type: research