NLRP3 inflammasome inhibitor MCC950 attenuates primary dysmenorrhea in mice via the NF- κB/COX-2/PG pathway
Primary dysmenorrhea (PD) constitutes a common gynecological disease among young women. The NLRP3 inflammasome may be activated and expressed in PD, but the mechanistic link between NLRP3 inflammasome activati... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 24, 2020 Category: Allergy & Immunology Authors: Biao Tang, Dan Liu, Lingyu Chen and Yu Liu Tags: Research Source Type: research

SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping
The current pandemic of COVID-19 has caused severe morbidity and mortality across the globe. People with a smoking history have severe disease outcomes by COVID-19 infection. Epidemiological studies show that ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 10, 2020 Category: Allergy & Immunology Authors: Gagandeep Kaur, Giuseppe Lungarella and Irfan Rahman Tags: Review Source Type: research

A novel sphingosylphosphorylcholine and sphingosine-1-phosphate receptor 1 antagonist, KRO-105714, for alleviating atopic dermatitis
Atopic dermatitis (eczema) is a type of inflammation of the skin, which presents with itchy, red, swollen, and cracked skin. The high global incidence of atopic dermatitis makes it one of the major skin diseas... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 29, 2020 Category: Allergy & Immunology Authors: Sae-Bom Yoon, Chang Hoon Lee, Hyun Young Kim, Daeyoung Jeong, Moon Kook Jeon, Sun-A Cho, Kwangmi Kim, Taeho Lee, Jung Yoon Yang, Young-Dae Gong and Heeyeong Cho Tags: Research Source Type: research

Efficacy and safety of aerosol inhalation of recombinant human interferon α1b (IFNα1b) injection for noninfluenza viral pneumonia, a multicenter, randomized, double-blind, placebo-controlled trial
To investigate the efficacy and safety of aerosol inhalation of recombinant human interferon α1b (IFNα1b) injection for noninfluenza viral pneumonia. (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 14, 2020 Category: Allergy & Immunology Authors: Rongmeng Jiang, Bing Han, Meihua Song, Bing Xue, Yongxiang Zhang, Yanyan Ding, Jin Chen, Jing Zhu, Jianhua Liu, Qingrong Nie, Xuefeng Han, Xiuhong Jin, Xiaoyin Shan, Weian Guo, Erming Zhang, Zuoqing Zhang & hellip; Tags: Research Source Type: research

Inhibition of carrageenan-induced dental inflammatory responses owing to decreased TRPV1 activity by Dexmedetomidine
In this study, the inhibitory effect of Dex on i... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 1, 2020 Category: Allergy & Immunology Authors: Gang Lv, Guanhua Zhu, Maohua Xu, Xingping Gao and Qingfeng Xiao Tags: Research Source Type: research

MiRNA-494 enhances M1 macrophage polarization via Nrdp1 in ICH mice model
Ubiquitination-mediated M1/M2 macrophage polarization plays important roles in the pathogenesis of immune disease. However, the regulatory mechanism of ubiquitination during M1/M2 macrophage polarization follo... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 25, 2020 Category: Allergy & Immunology Authors: Gaohai Shao, Changlong Zhou, Kunlong Ma, Wang Zhao, Qijiang Xiong, Ling Yang, Zhongyan Huang and Zhao Yang Tags: Research Source Type: research

Ulcerative colitis: understanding its cellular pathology could provide insights into novel therapies
Dynamic interactions between the gastrointestinal epithelium and the mucosal immune system normally contribute to ensuring intestinal homeostasis and optimal immunosurveillance, but destabilisation of these in... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 21, 2020 Category: Allergy & Immunology Authors: Amandip Kaur and Paraskevi Goggolidou Tags: Review Source Type: research

Enhanced inflammasome activation and reduced sphingosine-1 phosphate S1P signalling in a respiratory mucoobstructive disease model
Inflammasomes and sphingosine-1-phosphate (S1P) signalling are increasingly subject to intensive research in human diseases. We hypothesize that in respiratory muco-obstructive diseases, mucus obstruction enha... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 21, 2020 Category: Allergy & Immunology Authors: Hai B. Tran, Matthew G. Macowan, Adrian Abdo, Martin Donnelley, David Parsons and Sandra Hodge Tags: Research Source Type: research

Elevated soluble TNF α levels and upregulated TNFα mRNA expression in purified peripheral blood monocyte subsets associated with high-grade hepatocellular carcinoma
Chronic inflammation is involved in the initiation and progression of various cancers, including liver cancer. The current study focuses on the characterization of the peripheral immune response in hepatocellu... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 30, 2020 Category: Allergy & Immunology Authors: C. Mart ín-Sierra, R. Martins, M. Coucelo, A. M. Abrantes, R. C. Oliveira, J. G. Tralhão, M. F. Botelho, E. Furtado, M. R. Domingues, A. Paiva and P. Laranjeira Tags: Research Source Type: research

Urolithin a attenuates IL-1 β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes
Osteoarthritis (OA) is characterized by inflammation and extracellular matrix (ECM) degradation and is one of the most common chronic degenerative joint diseases that causes pain and disability in adults. Urol... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 24, 2020 Category: Allergy & Immunology Authors: Sheng-long Ding, Zhi-ying Pang, Xue-mei Chen, Zheng Li, Xin-xin Liu, Qi-lin Zhai, Jun-ming Huang and Zhi-yong Ruan Tags: Research Source Type: research

The role of SOCS3 in the hypothalamic paraventricular nucleus in rat model of inflammatory pain
Inflammatory molecular signals are modulated by a variety of intracellular transduction pathways, the activation of which may induce and amplify the spread of inflammatory response. Suppresser of cytokine sign... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 27, 2020 Category: Allergy & Immunology Authors: Na Meng, Ning-Ning Ji, Ziming Zhou, Yicheng Qian, Yu Tang, Kangbo Yang, Binbin Chen and Yong-Mei Zhang Tags: Research Source Type: research

Prediction and identification of novel HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from endocan
Prediction and identification of cytotoxic T lymphocyte (CTL) epitopes from tumor associated antigens is a crucial step for the development of tumor immunotherapy strategy. Endocan has been identified as antig... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 19, 2020 Category: Allergy & Immunology Authors: Gaohai Shao, Qingjun Liu, Ling Yang, Guibo Feng, Wang Zhao, Zhongyan Huang and Zhao Yang Tags: Research Source Type: research

Circular RNA-CDR1as acts as the sponge of microRNA-641 to promote osteoarthritis progression
The antisense cerebellar degenerative-related protein-1 (CDR1as) has been identified as a sponge for several microRNAs. MiR-641 has been shown to be downregulated in osteoarthritic human chondrocytes, but its ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 18, 2020 Category: Allergy & Immunology Authors: Wei Zhang, Chi Zhang, Chengfang Hu, Congfeng Luo, Biao Zhong and Xiaowei Yu Tags: Research Source Type: research

Low-intensity ultrasound attenuates paw edema formation and decreases vascular permeability induced by carrageenan injection in rats
Therapeutic potential of low-intensity ultrasound (LIUS) has become evident in various musculoskeletal diseases. We have previously shown that LIUS has an inhibitory effect on local edema in various diseases i... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 13, 2020 Category: Allergy & Immunology Authors: Kil Hwan Kim, Hyeon-Woo Im, Mrigendra Bir Karmacharya, Sejong Kim, Byoung-Hyun Min, So Ra Park and Byung Hyune Choi Tags: Research Source Type: research

Real-state of autophagy signaling pathway in neurodegenerative disease; focus on multiple sclerosis
The occurrence of neurodegenerative disease is increasingly raised. From physiopathological aspect, the emergence of auto-reactive antibodies against the nervous system antigens contributes to de-myelination i... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 11, 2020 Category: Allergy & Immunology Authors: Mehdi Hassanpour, Fateme Hajihassani, Amirataollah Hiradfar, Nasser Aghamohammadzadeh, Reza Rahbarghazi, Nasser Safaie, Mohammad Nouri and Yunes Panahi Tags: Review Source Type: research

Acupoint application inhibits nerve growth factor and attenuates allergic inflammation in allergic rhinitis model rats
Acupoint application therapy (AAT) has been widely used to treat allergic inflammation induced by allergic rhinitis (AR). The therapeutic effect of acupoint application is obvious. But the underlying therapeut... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 10, 2020 Category: Allergy & Immunology Authors: Wenzhan Tu, Xiaolong Chen, Qiaoyun Wu, Xinwang Ying, Rong He, Xinfa Lou, Guanhu Yang, Kecheng Zhou and Songhe Jiang Tags: Research Source Type: research

Different signaling pathways involved in the anti-inflammatory effects of unfractionated heparin on lipopolysaccharide-stimulated human endothelial cells
There is a complex interplay between inflammatory response and coagulation in sepsis. Heparin is used as a recognized anticoagulant and possesses multiple biological properties that possibly affect sepsis. Thi... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 10, 2020 Category: Allergy & Immunology Authors: Xu Li, Lu Li, Yuequan Shi, Sihan Yu and Xiaochun Ma Tags: Research Source Type: research

Dendritic cells transduced with glioma-expressed antigen 2 recombinant adenovirus induces specific cytotoxic lymphocyte response and anti-tumor effect in mice
Glioma is an aggressive common cancer with high mortality worldwide. Up to date, the effective medical therapeutical strategy is limited. Numerous previous studies have indicated that glioma-expressed antigen ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 31, 2020 Category: Allergy & Immunology Authors: Gaohai Shao, Changlong Zhou, Kunlong Ma, Wang Zhao, Guibo Feng, Qijiang Xiong, Ling Yang and Zhao Yang Tags: Research Source Type: research

Corpus cavernosum smooth muscle cell dysfunction and phenotype transformation are related to erectile dysfunction in prostatitis rats with chronic prostatitis/chronic pelvic pain syndrome
This study was... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 6, 2020 Category: Allergy & Immunology Authors: Guang-chun Wang, Tian-run Huang, Yang-yang Hu, Ke-yi Wang, Heng Shi, Lei Yin and Bo Peng Tags: Research Source Type: research

Effects of long non-coding RNA Gm14461 on pain transmission in trigeminal neuralgia
This study aims to investigate the role of long non-coding RNA Gm14461 in regulating pain transmission in trigeminal neuralgia (TN). The mouse TN model was produced by chronic constriction injury of the infrao... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 3, 2020 Category: Allergy & Immunology Authors: Mu Xu, Yi Yan, Mengye Zhu, Zhijian Wang, Xuexue Zhang and Daying Zhang Tags: Research Source Type: research

Nerve growth factor inhibits TLR3-induced inflammatory cascades in human corneal epithelial cells
In herpes simplex epithelial keratitis, excessive TLR3-induced cellular responses after virus infection evoke inflammatory cascades that might be destructive to the host cornea. Nerve growth factor (NGF), a pl... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 26, 2019 Category: Allergy & Immunology Authors: Huiyu Chen, Jing Zhang, Yiqin Dai and Jianjiang Xu Tags: Research Source Type: research

Exploring the association of IL-10 polymorphisms in Behcet ’s disease: a systematic review and meta-analysis
This study aimed to perform a meta-analysis of eligible studies ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 23, 2019 Category: Allergy & Immunology Authors: Elham Shahriyari, Leila Vahedi, Nasrin Roshanipour, Mohammad Asghari Jafarabadi, Amin Khamaneh and Maryam Ghaffari Laleh Tags: Research Source Type: research

The double edge of anti-CD40 siRNA therapy: It increases renal microcapillar density but favours the generation of an inflammatory milieu in the kidneys of ApoE −/− mice
Chronic kidney disease (CKD) is associated with endothelial dysfunctions thus prompting links between microcirculation (MC), inflammation and major cardiovascular risk factors. (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 16, 2019 Category: Allergy & Immunology Authors: Miguel Hueso, Angela Casas, Adrian Mall én, Laura de Ramón, Nuria Bolaños, Cristian Varela, Josep M. Cruzado, Joan Torras and Estanislao Navarro Tags: Research Source Type: research

Nrdp1 increases neuron apoptosis via downregulation of Bruce following intracerebral haemorrhage
Neuregulin receptor degradation protein-1 (Nrdp1) is an E3 ubiquitin ligase that plays an important role in regulating cell growth, apoptosis and oxidative stress. However, the data regarding its expression an... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 9, 2019 Category: Allergy & Immunology Authors: Changlong Zhou, Qingjun Liu, Wang Zhao, Ling Yang, Zhongyan Huang and Zhao Yang Tags: Research Source Type: research

LncRNA H19 induced by helicobacter pylori infection promotes gastric cancer cell growth via enhancing NF- κB-induced inflammation
The aim of this study was to investigate the role of long non-coding RNA (lncRNA) H19 in gastric cancer (GC) with Helicobacter pylori (H. pylori). (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 26, 2019 Category: Allergy & Immunology Authors: Yifeng Zhang, Jin Yan, Chao Li, Xiaoyong Wang, Yu Dong, Xiaoran Shen and Ximei Zhang Tags: Research Source Type: research

Mesangial cells are key contributors to the fibrotic damage seen in the lupus nephritis glomerulus
Lupus nephritis (LN) affects up to 80% of juvenile-onset systemic lupus erythematosus patients. Mesangial cells (MCs) comprise a third of the glomerular cells and are key contributors to fibrotic changes withi... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 14, 2019 Category: Allergy & Immunology Authors: Rachael D. Wright, Paraskevi Dimou, Sarah J. Northey and Michael W. Beresford Tags: Research Source Type: research

Liraglutide exhibits anti-inflammatory activity through the activation of the PKA/CREB pathway
Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their f... (Source: Journal of Inflammation)
Source: Journal of Inflammation - October 11, 2019 Category: Allergy & Immunology Authors: Li Wang, Linjie Feng and Jingyu Zhang Tags: Commentary Source Type: research

Structural and functional abnormalities of penile cavernous endothelial cells result in erectile dysfunction at experimental autoimmune prostatitis rat
There is growing recognition of the association of CP/CPPS accompany with ED. However, the specific mechanism of action remains unclear. The aim of this study was to investigate structural and functional abnor... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 25, 2019 Category: Allergy & Immunology Authors: Tianrun Huang, Guangchun Wang, Yangyang Hu, Heng Shi, Keyi Wang, Lei Yin and Bo Peng Tags: Research Source Type: research

IL-35 alleviates inflammation progression in a rat model of diabetic neuropathic pain via inhibition of JNK signaling
Emerging evidence has demonstrated that inflammation is involved in the occurrence and development of diabetic neuropathic pain (DNP). The anti-inflammatory property of interleukin (IL)-35 makes it a promising... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 23, 2019 Category: Allergy & Immunology Authors: Yinghai Jiang, Jing Wang, Haiqin Li and Lingjie Xia Tags: Research Source Type: research

The in vitro Mycobacterium bovis BCG Moreau infection of human monocytes that induces Caspase-1 expression, release and dependent cell death is mostly reliant upon cell integrity
Caused by Mycobacterium tuberculosis, tuberculosis (TB) is an extremely contagious disease predominantly affecting the lungs. TB is found worldwide and has a major impact on public health safety primarily due to ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 15, 2019 Category: Allergy & Immunology Authors: Paulo R. Z. Antas, Carlos G. G. Ponte, Matheus R. Almeida, Lawrence H. P. Albuquerque, Periela S. Sousa-Vasconcelos, Tha íze Pedro, Natália L. S. Gomes, Otacílio C. Moreira, Fernanda C. Silva, Luíz R. R. Castello-Branco and Rosa T. Pinho Tags: Research Source Type: research

Deficiency of fibroblast growth factor 21 aggravates obesity-induced atrophic responses in skeletal muscle
Obesity-induced skeletal muscle inflammation is a major contributor of skeletal muscle loss/atrophy and is implicated in metabolic complications such as insulin resistance. Fibroblast growth factor 21 (FGF21) ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 4, 2019 Category: Allergy & Immunology Authors: Chu-Sook Kim, Yeonsoo Joe, Hye-Seon Choi, Sung Hoon Back, Jeong Woo Park, Hun Taeg Chung, Eun Roh, Min-Seon Kim, Tae Youl Ha and Rina Yu Tags: Research Source Type: research

Hypertonic solution-induced preconditioning reduces inflammation and mortality rate
Dysregulated inflammatory response is common cause of organ damage in critical care patients. Preconditioning/tolerance is a strategy to prevent exacerbated inflammation. The aim of this study is to analyze hy... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 3, 2019 Category: Allergy & Immunology Authors: Rosangela Nascimento Pimentel, Ricardo Costa Petroni, Hermes Vieira Barbeiro, Denise Frediani Barbeiro, Mariana Macedo Andrade, Suely Kumini Ariga and Francisco Garcia Soriano Tags: Research Source Type: research

“In sickness and in health” – how neutrophil extracellular trap (NET) works in infections, selected diseases and pregnancy
The discovery of the NET network (neutrophil extracellular trap) has revolutionized the perception of defense mechanisms used by neutrophils in infections and non-infectious states, as this mechanism proves th... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 28, 2019 Category: Allergy & Immunology Authors: Paulina Nied źwiedzka-Rystwej, Weronika Repka, Beata Tokarz-Deptuła and Wiesław Deptuła Tags: Review Source Type: research

High-fat diet-induced obesity causes an inflammatory microenvironment in the kidneys of aging Long-Evans rats
Obesity is a risk factor for chronic kidney disease (CKD). While the exact mechanisms remain unclear, inflammation may be a consequence of obesity that directly impacts the kidneys. The aim of this study was t... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 25, 2019 Category: Allergy & Immunology Authors: Thea Laurentius, Ute Raffetseder, Claudia Fellner, Robert Kob, Mahtab Nourbakhsh, J ürgen Floege, Thomas Bertsch, Leo Cornelius Bollheimer and Tammo Ostendorf Tags: Research Source Type: research

The GLP-1 agonist, liraglutide, ameliorates inflammation through the activation of the PKA/CREB pathway in a rat model of knee osteoarthritis
Inflammation is a common pathological phenomenon of osteoarthritis (OA). Accumulated evidence indicates that ameliorating or suppressing inflammation might be a promising and effective therapeutic strategy for... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 6, 2019 Category: Allergy & Immunology Authors: Qihong Que, Xinghua Guo, Longxin Zhan, Shaodong Chen, Zengli Zhang, Xiaoming Ni, Bin Ye and Shuanglin Wan Tags: Research Source Type: research

Ferroptosis inhibitor alleviates Radiation-induced lung fibrosis (RILF) via down-regulation of TGF- β1
Radiation-induced lung fibrosis (RILF) is a severe and life-threatening complication of thoracic radiotherapy. Cell death is the key issue in RILF. Ferroptosis is a form programmed cell death implicated in the... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 29, 2019 Category: Allergy & Immunology Authors: Xuan Li, Lijie Duan, Sujuan Yuan, Xibing Zhuang, Tiankui Qiao and Jian He Tags: Research Source Type: research

Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice
Ischemia-reperfusion injury (IRI) is an antigen-independent, innate immune response to arterial occlusion and ischemia with subsequent paradoxical exacerbation after reperfusion. IRI remains a critical problem... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 29, 2019 Category: Allergy & Immunology Authors: Jordan R. Yaron, Hao Chen, Sriram Ambadapadi, Liqiang Zhang, Amanda M. Tafoya, Barbara H. Munk, Dara N. Wakefield, Jorge Fuentes, Bruno J. Marques, Krishna Harripersaud, Mee Yong Bartee, Jennifer A. Davids, Donghang Zheng, Kenneth Rand, Lisa Dixon, Richar Tags: Short Report Source Type: research

Evidence for the important role of inflammation in xenotransplantation
There is increasing evidence of a sustained state of systemic inflammation after pig-to-nonhuman primate (NHP) xenotransplantation (that has been termed systemic inflammation in xenograft recipients [SIXR]). I... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 28, 2019 Category: Allergy & Immunology Authors: Juan Li, Hidetaka Hara, Yi Wang, Charles Esmon, David K. C. Cooper and Hayato Iwase Tags: Review Source Type: research

Anti-vascular endothelial growth factor agent reduces inflammation in macular edema with central retinal vein occlusion
Correlations among the aqueous flare value (an indicator of inflammation), functional-morphologic parameters, and aqueous humor levels of growth factors/receptors and inflammatory factors/cytokines were invest... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 22, 2019 Category: Allergy & Immunology Authors: Asako Mashima, Hidetaka Noma, Kanako Yasuda, Hiroshi Goto and Masahiko Shimura Tags: Research Source Type: research

Role of autophagy in atherosclerosis: foe or friend?
Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular walls. Different mechanisms and pathological features are evident at the onset of atherosclerotic changes via the enga... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 2, 2019 Category: Allergy & Immunology Authors: Mehdi Hassanpour, Reza Rahbarghazi, Mohammad Nouri, Nasser Aghamohammadzadeh, Nasser Safaei and Mahdi Ahmadi Tags: Review Source Type: research

Accumulation of free cholesterol and oxidized low-density lipoprotein is associated with portal inflammation and fibrosis in nonalcoholic fatty liver disease
Macrophages engulf oxidized-LDL (oxLDL) leading to accumulation of cellular cholesterol and formation of foam cells, which is a hallmark of atherosclerosis. Moreover, recent studies showed that accumulation of... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 2, 2019 Category: Allergy & Immunology Authors: Cheng-Maw Ho, Shu-Li Ho, Yung-Ming Jeng, Yu-Sheng Lai, Ya-Hui Chen, Shao-Chun Lu, Hui-Ling Chen, Po-Yuan Chang, Rey-Heng Hu and Po-Huang Lee Tags: Research Source Type: research

Decrease in inflammatory biomarker concentration by intervention with selenium and coenzyme Q10: a subanalysis of osteopontin, osteoprotergerin, TNFr1, TNFr2 and TWEAK
Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiovascular mortality, and increase cardiac function in elderly persons ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 18, 2019 Category: Allergy & Immunology Authors: Urban Alehagen, Jan Alexander, Jan Aaseth and Anders Larsson Tags: Research Source Type: research

SNP variations in IL10, TNF α and TNFAIP3 genes in patients with dry eye syndrome and Sjogren’s syndrome
In this study we compared single nucleotide polymorphism (SNP) variations in genes encoding cytokine le... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 18, 2019 Category: Allergy & Immunology Authors: Hadas Ben-Eli, Nir Gomel, Doron Jacob Aframian, Rania Abu-Seir, Riki Perlman, Eldad Ben-Chetrit, dror Mevorach, Geffen Kleinstern, Ora Paltiel and Abraham Solomon Tags: Research Source Type: research

Extracellular acidification-induced CXCL8 production through a proton-sensing receptor OGR1 in human airway smooth muscle cells: a response inhibited by dexamethasone
Human airway smooth muscle cells (ASMCs) contribute to bronchial contraction and airway hyperresponsiveness in patients with bronchial asthma. They also generate cytokines, chemokines, and matricellular protei... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 19, 2019 Category: Allergy & Immunology Authors: Maiko Kadowaki, Hidenori Yamada, Koichi Sato, Hiroko Shigemi, Yukihiro Umeda, Miwa Morikawa, Yuko Waseda, Masaki Anzai, Yosuke Kamide, Haruka Aoki-Saito, Takeshi Hisada, Fumikazu Okajima and Tamotsu Ishizuka Tags: Research Source Type: research

LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture
Sepsis is a systemic inflammatory response syndrome caused by severe infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory function against sepsis. Micro- and macro-circ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 18, 2019 Category: Allergy & Immunology Authors: Weiwei Ge, Qiaohua Hu, Xiangshao Fang, Juanhua Liu, Jing Xu, Juntao Hu, Xuefen Liu, Qin Ling, Yue Wang, He Li, Ming Gao, Longyuan Jiang, Zhengfei Yang and Wanchun Tang Tags: Research Source Type: research

Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis
In order to gain insight into the early effects drawn by JAK inhibitors on intra-joint JAK/STAT-dependent signaling, we sought synovial activation of STATs and their end-products, along with their modification... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 29, 2019 Category: Allergy & Immunology Authors: Sandra P érez-Baos, Paula Gratal, Juan I. Barrasa, Ana Lamuedra, Olga Sánchez-Pernaute, Gabriel Herrero-Beaumont and Raquel Largo Tags: Research Source Type: research

Biomarkers for Acute Respiratory Distress syndrome and prospects for personalised medicine
Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute respiratory distress syndrome (ARDS) being the most severe form of ALI and having a mortality rate in the region o... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 15, 2019 Category: Allergy & Immunology Authors: Savino Spadaro, Mirae Park, Cecilia Turrini, Tanushree Tunstall, Ryan Thwaites, Tommaso Mauri, Riccardo Ragazzi, Paolo Ruggeri, Trevor T. Hansel, Gaetano Caramori and Carlo Alberto Volta Tags: Review Source Type: research

The role of N-glycosylation of CD200-CD200R1 interaction in classical microglial activation
Microglial inflammatory activation is the common feature of the central nervous system (CNS) diseases. Microglia can be activated and particularly polarized toward a dual role in the injured CNS. The CD200 rec... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 19, 2018 Category: Allergy & Immunology Authors: Chao Liu, Yifen Shen, Ying Tang and Yongchun Gu Tags: Research Source Type: research

Transient receptor potential ankyrin 1 (trpa1) mediates il-1 β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction
Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger. ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 17, 2018 Category: Allergy & Immunology Authors: Songjiang Yin, Li Zhang, Liang Ding, Zhengquan Huang, Bo Xu, XiaoChen Li, Peimin Wang and Jun Mao Tags: Research Source Type: research

Dynamics of soluble vascular endothelial growth factor receptors and their ligands in aqueous humour during ranibizumab for age-related macular degeneration
Intravitreal ranibizumab injection (IRI) is effective for patients with exudative age-related macular degeneration (AMD) and decreases intraocular levels of vascular endothelial growth factor (VEGF), but VEGF ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 4, 2018 Category: Allergy & Immunology Authors: Ryosuke Motohashi, Hidetaka Noma, Kanako Yasuda, Osamu Kotake, Hiroshi Goto and Masahiko Shimura Tags: Research Source Type: research