IL-33-ST2 signaling in fibro-adipogenic progenitors alleviates immobilization-induced muscle atrophy in mice
The regenerative and adaptive capacity of skeletal muscles reduces with age, leading to severe disability and frailty in the elderly. Therefore, development of effective therapeutic interventions for muscle wa... (Source: Skeletal Muscle)
Source: Skeletal Muscle - April 1, 2024 Category: Research Authors: Yoshiyuki Takahashi, Masaki Yoda, Osahiko Tsuji, Keisuke Horiuchi, Kota Watanabe and Masaya Nakamura Tags: Research Source Type: research
Metabolic signatures and potential biomarkers of sarcopenia in suburb-dwelling older Chinese: based on untargeted GC –MS and LC–MS
Untargeted metabolomics can be used to expand our understanding of the pathogenesis of sarcopenia. However, the metabolic signatures of sarcopenia patients have not been thoroughly investigated. Herein, we exp... (Source: Skeletal Muscle)
Source: Skeletal Muscle - March 7, 2024 Category: Research Authors: Peipei Han, Chunhua Yuan, Xiaoyu Chen, Yuanqing Hu, Xiaodan Hu, Zhangtao Xu and Qi Guo Tags: Research Source Type: research
Motor neurons and endothelial cells additively promote development and fusion of human iPSC-derived skeletal myocytes
Neurovascular cells have wide-ranging implications on skeletal muscle biology regulating myogenesis, maturation, and regeneration. Although several in vitro studies have investigated how motor neurons and endo... (Source: Skeletal Muscle)
Source: Skeletal Muscle - March 7, 2024 Category: Research Authors: Suradip Das, Melanie C. Hilman, Feikun Yang, Foteini Mourkioti, Wenli Yang and D. Kacy Cullen Tags: Research Source Type: research
A knock down strategy for rapid, generic, and versatile modelling of muscular dystrophies in 3D-tissue-engineered-skeletal muscle
Human iPSC-derived 3D-tissue-engineered-skeletal muscles (3D-TESMs) offer advanced technology for disease modelling. However, due to the inherent genetic heterogeneity among human individuals, it is often diff... (Source: Skeletal Muscle)
Source: Skeletal Muscle - February 22, 2024 Category: Research Authors: Stijn L. M. in ‘t Groen, Marnix Franken, Theresa Bock, Marcus Krüger, Jessica C. de Greef and W. W. M. Pim Pijnappel Tags: Methodology Source Type: research
N-terminal titin fragment: a non-invasive, pharmacodynamic biomarker for microdystrophin efficacy
Multiple clinical trials to assess the efficacy of AAV-directed gene transfer in participants with Duchenne muscular dystrophy (DMD) are ongoing. The success of these trials currently relies on standard functi... (Source: Skeletal Muscle)
Source: Skeletal Muscle - January 16, 2024 Category: Research Authors: Jessica F. Boehler, Kristy J. Brown, Valeria Ricotti and Carl A. Morris Tags: Research Source Type: research
The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt-mTOR signaling
Myofiber size regulation is critical in health, disease, and aging. MuSK (muscle-specific kinase) is a BMP (bone morphogenetic protein) co-receptor that promotes and shapes BMP signaling. MuSK is expressed at ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - January 3, 2024 Category: Research Authors: Diego Jaime, Lauren A. Fish, Laura A. Madigan, Chengjie Xi, Giorgia Piccoli, Madison D. Ewing, Bert Blaauw and Justin R. Fallon Tags: Research Source Type: research
Eldecalcitol prevents muscle loss and osteoporosis in disuse muscle atrophy via NF- κB signaling in mice
We investigated the effect of eldecalcitol on disuse muscle atrophy. C57BL/6J male mice aged 6 weeks were randomly assigned to control, tail suspension (TS), and TS-eldecalcitol –treated groups and were injecte... (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 19, 2023 Category: Research Authors: Haichao Zhang, Yanping Du, Wenjing Tang, Minmin Chen, Weijia Yu, Zheng Ke, Shuangshuang Dong and Qun Cheng Tags: Research Source Type: research
Restoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in MAFLD
Cross-sectional studies have demonstrated the association of skeletal muscle mass with metabolic-associated fatty liver disease (MAFLD), while longitudinal data are scarce. We aimed to explore the impact of ch... (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 19, 2023 Category: Research Authors: Ting Zhou, Junzhao Ye, Ling Luo, Wei Wang, Shiting Feng, Zhi Dong, Shuyu Zhuo and Bihui Zhong Tags: Research Source Type: research
Hypoxia enhances human myoblast differentiation: involvement of HIF1 α and impact of DUX4, the FSHD causal gene
Hypoxia is known to modify skeletal muscle biological functions and muscle regeneration. However, the mechanisms underlying the effects of hypoxia on human myoblast differentiation remain unclear. The hypoxic ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 16, 2023 Category: Research Authors: Thuy-Hang Nguyen, Lise Paprzycki, Alexandre Legrand, Anne-Emilie Decl èves, Philipp Heher, Maelle Limpens, Alexandra Belayew, Christopher R. S. Banerji, Peter S. Zammit and Alexandra Tassin Tags: Research Source Type: research
Replenishing NAD+ content reduces aspects of striated muscle disease in a dog model of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in DMD gene and loss of the protein dystrophin, which ultimately leads to myofiber membrane fragility and necrosis, with eventual muscl... (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 4, 2023 Category: Research Authors: D éborah Cardoso, Inès Barthélémy, Stéphane Blot and Antoine Muchir Tags: Research Source Type: research
Electrical impedance myography detects dystrophin-related muscle changes in mdx mice
The lack of functional dystrophin protein in Duchenne muscular dystrophy (DMD) causes chronic skeletal muscle inflammation and degeneration. Therefore, the restoration of functional dystrophin levels is a fund... (Source: Skeletal Muscle)
Source: Skeletal Muscle - November 18, 2023 Category: Research Authors: Tetsuaki Hiyoshi, Fuqiang Zhao, Rina Baba, Takeshi Hirakawa, Ryosuke Kuboki, Kazunori Suzuki, Yoshiro Tomimatsu, Patricio O ’Donnell, Steve Han, Neta Zach and Masato Nakashima Tags: Research Source Type: research
Tropomyosin 3 (TPM3) function in skeletal muscle and in myopathy
The tropomyosin genes (TPM1-4) contribute to the functional diversity of skeletal muscle fibers. Since its discovery in 1988, the TPM3 gene has been recognized as an indispensable regulator of muscle contraction ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - November 7, 2023 Category: Research Authors: Matthias R. Lambert and Emanuela Gussoni Tags: Review Source Type: research
DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults
While ageing is associated with increased insulin resistance (IR), the molecular mechanisms underlying increased IR in the muscle, the primary organ for glucose clearance, have yet to be elucidated in older in... (Source: Skeletal Muscle)
Source: Skeletal Muscle - October 28, 2023 Category: Research Authors: Mark A. Burton, Emma S. Garratt, Matthew O. Hewitt, Hanan Y. Sharkh, Elie Antoun, Leo D. Westbury, Elaine M. Dennison, Nicholas C. Harvey, Cyrus Cooper, Julia L. MacIsaac, Michael S. Kobor, Harnish P. Patel, Keith M. Godfrey and Karen A. Lillycrop Tags: Research Source Type: research
Sox11 is enriched in myogenic progenitors but dispensable for development and regeneration of the skeletal muscle
Transcription factors (TFs) play key roles in regulating differentiation and function of stem cells, including muscle satellite cells (MuSCs), a resident stem cell population responsible for postnatal regenera... (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 13, 2023 Category: Research Authors: Stephanie N. Oprescu, Nick Baumann, Xiyue Chen, Qiang Sun, Yu Zhao, Feng Yue, Huating Wang and Shihuan Kuang Tags: Research Source Type: research
Biomarkers for Duchenne muscular dystrophy progression: impact of age in the mdx tongue spared muscle
Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy without an effective treatment, caused by mutations in the DMD gene, leading to the absence of dystrophin. DMD results in muscle weakness, ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 13, 2023 Category: Research Authors: Marcelo dos Santos Voltani Lorena, Estela Kato dos Santos, Renato Ferretti, G. A. Nagana Gowda, Guy L. Odom, Jeffrey S. Chamberlain and Cintia Yuri Matsumura Tags: Research Source Type: research
