Progression of herpesvirus infection remodels mitochondrial organization and metabolism
PLoS Pathog. 2024 Apr 15;20(4):e1011829. doi: 10.1371/journal.ppat.1011829. Online ahead of print.ABSTRACTViruses target mitochondria to promote their replication, and infection-induced stress during the progression of infection leads to the regulation of antiviral defenses and mitochondrial metabolism which are opposed by counteracting viral factors. The precise structural and functional changes that underlie how mitochondria react to the infection remain largely unclear. Here we show extensive transcriptional remodeling of protein-encoding host genes involved in the respiratory chain, apoptosis, and structural organizati...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Simon Leclerc Alka Gupta Visa Ruokolainen Jian-Hua Chen Kari Kunnas Axel A Ekman Henri Niskanen Ilya Belevich Helena Vihinen Paula Turkki Ana J Perez-Berna Sergey Kapishnikov Elina M äntylä Maria Harkiolaki Eric Dufour Vesa Hyt önen Eva Pereiro Tony Mc Source Type: research
Extracellular mitochondrial components as new biomarkers for lupus nephritis
This study has evaluated extracellular mitochondrial components, including cell-free mitochondria, and cell-free mitochondrial DNA as probable biomarkers of the degree of nephritis. Both showed a significant correlation with proteinuria and protein-creatinine ratio. Our study substantiates their usage as clinical biomarkers of nephritis upon their validation in a larger cohort of lupus nephritis patients and other forms of nephritis. Although the current data suggest using cell-free mitochondria as a biomarker of lupus nephritis is better than the cell-free mitochondrial DNA.PMID:38621786 | DOI:10.1177/09612033241247622 (Source: Lupus)
Source: Lupus - April 15, 2024 Category: Rheumatology Authors: Sharath Gowda Khushboo Rana Ankit Kumar Pradip Kumar Prajapati Namisha Patel Sapan Pandya Ratika Srivastava Source Type: research
Endothelial Mitochondria-Associated Membranes (MAMs) Isolation by Percoll Step Gradients
Methods Mol Biol. 2024;2782:113-122. doi: 10.1007/978-1-0716-3754-8_8.ABSTRACTMitochondria-associated membranes (MAMs) are regions where the endoplasmic reticulum (ER) interacts with mitochondria and regulate lipid trafficking, calcium signaling, ER stress, and inflammation activation. Isolation of MAMs from endothelial cells is vital for studying insight into the immune regulation of many inflammatory diseases. Endothelial cells (ECs) are critical innate immune cells due to their paracrine function of secreting interleukins, chemokines, cytokines, and growth factors, as well as expressing levels of pattern recognition rec...
Source: Mol Biol Cell - April 15, 2024 Category: Molecular Biology Authors: Margaret Baldini Cheng Zhang Jun Yu Source Type: research
The role and mechanism of PDZ binding kinase in hypobaric and hypoxic acute lung injury
CONCLUSIONS: Overexpression of PBK inhibits the expression of p53 and activates SIRT1-PINK1 axis mediated mitochondrial autophagy to alleviate HHALI.PMID:38617778 | PMC:PMC11009593 | DOI:10.21037/jtd-24-188 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Linao Sun Haoran Yue Hao Fang Runze Li Shicong Li Jianyao Wang Pengjie Tu Fei Meng Wang Yan Jinxia Zhang Elena Bignami Kyeongman Jeon Biniam Kidane Peng Zhang Source Type: research
Anthocyanins from blueberry ameliorated arsenic-induced memory impairment, oxidative stress, and mitochondrial-biosynthesis imbalance in rat hippocampal neurons
This study provides new insights into the detoxification effect of anthocyanins on the nervous system toxicity caused by metal exposure in the environment, indicating that anthocyanins may be a natural antioxidant against the nervous system toxicity caused by environmental metal exposure.PMID:38621470 | DOI:10.1016/j.cellsig.2024.111177 (Source: Cellular Signalling)
Source: Cellular Signalling - April 15, 2024 Category: Cytology Authors: Xinbo Ma Yang Liu Bo Ding Siqi Lu Bangyao Ni Yuting Chen Liu Yang Yanan Liu Yuchen Zhang Yuxi Wang Yanmei Yang Xiaona Liu Source Type: research
Role of mitochondria in doxorubicin-mediated cardiotoxicity: from molecular mechanisms to therapeutic strategies
In conclusion, this review offers valuable insights into the intricate relationship between mitochondrial dysfunction and doxorubicin-mediated cardiotoxicity. It underscores the need for continued research into targeted mitochondrial therapies as a means to improve the cardiac safety profile of doxorubicin, thereby enhancing the overall treatment outcomes for cancer patients.PMID:38617011 | PMC:PMC11008476 | DOI:10.7150/ijms.94485 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Tianen Wang Guoli Xing Tong Fu Yanchun Ma Qi Wang Shuxiang Zhang Xing Chang Ying Tong Source Type: research
Protective Effect of Fermented Sea Tangle Extract on Skin Cell Damage Caused by Particulate Matter
Int J Med Sci. 2024 Mar 31;21(5):937-948. doi: 10.7150/ijms.93034. eCollection 2024.ABSTRACTThe skin is directly exposed to atmospheric pollutants, especially particulate matter 2.5 (PM2.5) in the air, which poses significant harm to skin health. However, limited research has been performed to identify molecules that can confer resistance to such substances. Herein, we analyzed the effect of fermented sea tangle (FST) extract on PM2.5-induced human HaCaT keratinocyte damage. Results showed that FST extract, at concentrations less than 800 μg/mL, exhibited non-significant toxicity to cells and concentration-dependent inhib...
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Mei Jing Piao Kyoung Ah Kang Pincha Devage Sameera Madushan Fernando Herath Mudiyanselage Udari Lakmini Herath Young Sang Koh Hee Kyoung Kang Yung Hyun Choi Jin Won Hyun Source Type: research
Effects of Dietary Restriction on PGC-1 α Regulation in the Development of Age-associated Diseases
In conclusion, dietary interventions may delay ageing by regulating healthy mitochondria in various organs, presenting the possibility of a new primary prevention for many age-related diseases.PMID:38616758 | DOI:10.2174/0118746098301226240402051508 (Source: Current Aging Science)
Source: Current Aging Science - April 15, 2024 Category: Geriatrics Authors: Shefilyn Widjaja Radiana Dhewayani Antarianto Novi Silvia Hardiany Source Type: research
Altered lactate/pyruvate ratio may be responsible for aging-associated intestinal barrier dysfunction in male rats
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10102-0. Online ahead of print.ABSTRACTSome evidence points to a link between aging-related increased intestinal permeability and mitochondrial dysfunction in in-vivo models. Several studies have also demonstrated age-related accumulation of the of specific deletion 4834-bp of "common" mitochondrial DNA (mtDNA) in various rat tissues and suggest that this deletion may disrupt mitochondrial metabolism. The present study aimed to investigate possible associations among the mitochondrial DNA (mtDNA) common deletion, mitochondrial function, intestinal permeability, and aging...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Berrin Papila Ayla Karimova Ilhan Onaran Source Type: research
The role and mechanism of PDZ binding kinase in hypobaric and hypoxic acute lung injury
CONCLUSIONS: Overexpression of PBK inhibits the expression of p53 and activates SIRT1-PINK1 axis mediated mitochondrial autophagy to alleviate HHALI.PMID:38617778 | PMC:PMC11009593 | DOI:10.21037/jtd-24-188 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Linao Sun Haoran Yue Hao Fang Runze Li Shicong Li Jianyao Wang Pengjie Tu Fei Meng Wang Yan Jinxia Zhang Elena Bignami Kyeongman Jeon Biniam Kidane Peng Zhang Source Type: research
Anthocyanins from blueberry ameliorated arsenic-induced memory impairment, oxidative stress, and mitochondrial-biosynthesis imbalance in rat hippocampal neurons
This study provides new insights into the detoxification effect of anthocyanins on the nervous system toxicity caused by metal exposure in the environment, indicating that anthocyanins may be a natural antioxidant against the nervous system toxicity caused by environmental metal exposure.PMID:38621470 | DOI:10.1016/j.cellsig.2024.111177 (Source: Cellular Signalling)
Source: Cellular Signalling - April 15, 2024 Category: Cytology Authors: Xinbo Ma Yang Liu Bo Ding Siqi Lu Bangyao Ni Yuting Chen Liu Yang Yanan Liu Yuchen Zhang Yuxi Wang Yanmei Yang Xiaona Liu Source Type: research
Role of mitochondria in doxorubicin-mediated cardiotoxicity: from molecular mechanisms to therapeutic strategies
In conclusion, this review offers valuable insights into the intricate relationship between mitochondrial dysfunction and doxorubicin-mediated cardiotoxicity. It underscores the need for continued research into targeted mitochondrial therapies as a means to improve the cardiac safety profile of doxorubicin, thereby enhancing the overall treatment outcomes for cancer patients.PMID:38617011 | PMC:PMC11008476 | DOI:10.7150/ijms.94485 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Tianen Wang Guoli Xing Tong Fu Yanchun Ma Qi Wang Shuxiang Zhang Xing Chang Ying Tong Source Type: research
Protective Effect of Fermented Sea Tangle Extract on Skin Cell Damage Caused by Particulate Matter
Int J Med Sci. 2024 Mar 31;21(5):937-948. doi: 10.7150/ijms.93034. eCollection 2024.ABSTRACTThe skin is directly exposed to atmospheric pollutants, especially particulate matter 2.5 (PM2.5) in the air, which poses significant harm to skin health. However, limited research has been performed to identify molecules that can confer resistance to such substances. Herein, we analyzed the effect of fermented sea tangle (FST) extract on PM2.5-induced human HaCaT keratinocyte damage. Results showed that FST extract, at concentrations less than 800 μg/mL, exhibited non-significant toxicity to cells and concentration-dependent inhib...
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Mei Jing Piao Kyoung Ah Kang Pincha Devage Sameera Madushan Fernando Herath Mudiyanselage Udari Lakmini Herath Young Sang Koh Hee Kyoung Kang Yung Hyun Choi Jin Won Hyun Source Type: research
Role of mitochondria in doxorubicin-mediated cardiotoxicity: from molecular mechanisms to therapeutic strategies
In conclusion, this review offers valuable insights into the intricate relationship between mitochondrial dysfunction and doxorubicin-mediated cardiotoxicity. It underscores the need for continued research into targeted mitochondrial therapies as a means to improve the cardiac safety profile of doxorubicin, thereby enhancing the overall treatment outcomes for cancer patients.PMID:38617011 | PMC:PMC11008476 | DOI:10.7150/ijms.94485 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Tianen Wang Guoli Xing Tong Fu Yanchun Ma Qi Wang Shuxiang Zhang Xing Chang Ying Tong Source Type: research
Protective Effect of Fermented Sea Tangle Extract on Skin Cell Damage Caused by Particulate Matter
Int J Med Sci. 2024 Mar 31;21(5):937-948. doi: 10.7150/ijms.93034. eCollection 2024.ABSTRACTThe skin is directly exposed to atmospheric pollutants, especially particulate matter 2.5 (PM2.5) in the air, which poses significant harm to skin health. However, limited research has been performed to identify molecules that can confer resistance to such substances. Herein, we analyzed the effect of fermented sea tangle (FST) extract on PM2.5-induced human HaCaT keratinocyte damage. Results showed that FST extract, at concentrations less than 800 μg/mL, exhibited non-significant toxicity to cells and concentration-dependent inhib...
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Mei Jing Piao Kyoung Ah Kang Pincha Devage Sameera Madushan Fernando Herath Mudiyanselage Udari Lakmini Herath Young Sang Koh Hee Kyoung Kang Yung Hyun Choi Jin Won Hyun Source Type: research
