Aging In The Perspective Of Integrative Medicine, Psychoneuroendocrineimmunology And Hormesis - A Narrative Review.
Authors: Cavezzi A, Ambrosini L, Colucci R, Di Ionna G, Urso SU Abstract Aging has been considered a progressive decrease of a living organism homeodynamics , which indicates a reduction of the psycho-biological resilience. This narrative review provides an overview on the available literature related to the holistic approach of integrative medicine, psychoneuroendocrineimmunology (PNEI) and hormesis in aging process. On the basis of pathophysiology of cell senescence and of chronic degenerative diseases, possible preventive/therapeutic pathways have been examined. Chronic low grade cellular inflammation and chroni...
Source: Current Aging Science - November 30, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Development of an Efficient, Non-Invasive Method for Cardiovascular Disease Risk Stratification in a Resource-Limited Setting.
CONCLUSION: AIx is remarkably associated with cardiovascular risk as assessed by the WHO/ISH chart and the AIx cut-offs obtained in the study can be used as an efficient, non-invasive surrogate biomarker of cardiovascular risk even in resource-limited settings. PMID: 31769361 [PubMed - in process] (Source: Current Aging Science)
Source: Current Aging Science - November 28, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Novel Study of Model-based clustering Time Series Gene Expression in Different Tissues: Applications to Aging Process.
CONCLUSION: Results showed that most biological changes of aging between tissues are related to the specific components of immune cells. Also, the application MMVNDs can increases the ability to find similar genes. PMID: 31749443 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - November 23, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

An investigation of the anti-Parkinsonism potential of co-enzyme Q10 and co-enzyme Q10 /levodopa-carbidopa combination in mice.
CONCLUSION: Dietary CQ10-supplementation was associated with demonstrable benefits in CPZ-induced Parkinsonism-like changes in mice. PMID: 31702498 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - November 10, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

The impact of variable factors on the Health-Related Quality of Life in the elderly in Japan and Russia.
Authors: Kosilov K, Amedzawa H, Kuzina I, Kuznetsov V, Kosilova L Abstract AIM: The study of the impact of socio-economic, demographic factors and polymorbidity on the quality of life associated with health (HRQoL) in elderly people from Japan and Russia. BACKGROUND: Factors affecting the quality of life of the elderly in both countries are poorly understood. OBJECTIVE: Make a comparative analysis of factors affecting the quality of life of the elderly of both sexes in Japan and Russia. METHODS: Age range of the study is 65-95 years old. For the study of HRQoL a questionnaire Health Status Survey-Short ...
Source: Current Aging Science - November 10, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

The Concept of Successful Aging: A review article.
CONCLUSION: Health care professionals as community health supporters can use the results from the present study for providing the grounds for successful aging. Then, they can use the designed successful aging program for preserving and promoting active and healthy aging for every elderly person in old age. PMID: 31657693 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - October 30, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

The mechanism of programmed aging: The way to creation a real remedy for senescence.
CONCLUSION: The mechanism of programed aging points the way to achieving unlimited healthy life: it is necessary to develop a means for managing bioenergetics. More concrete, we have to modify mitochondrial mechanism that controls the [ATP]/[ADP] level. It has already been substantially studied by molecular biologists and is now waiting for researchers from gerontology. PMID: 31660847 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - October 30, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

rs3851179G > A in PICALM is protective against Alzheimer's disease in five different countries surrounding the Mediterranean.
CONCLUSION: rs3851179A allele in PICALM tends to have a protective factor against AD in the Mediterranean region. PMID: 31648652 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - October 29, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Usefulness of CSF Biomarkers in Predicting the Progression of Amnesic and Nonamnesic Mild Cognitive Impairment to Alzheimer's Disease.
Authors: Ortega RL, Dakterzada F, Arias A, Blasco E, Naudí A, Garcia FP, Piñol-Ripoll G Abstract OBJECTIVE: The aim of this study was to investigate the usefulness of Alzheimer's disease Cerebrospinal Fluid (CSF) biomarkers in predicting the progression to dementia in patients with Mild Cognitive Impairment (MCI). METHODS: One hundred and thirteen patients were consecutively recruited from April 2012 to April 2014. Measurement of CSF biomarkers (amyloid-β42 (Aβ42), total tau (t-tau) and phosphorylated tau (p-tau)) and a neuropsychological evaluation were performed for all patients. We ca...
Source: Current Aging Science - October 9, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Self-defining Memories in Normal Aging.
CONCLUSION: Updating our life story is an important psychological process,which enables us to refine and enrich our life story with new experiences, roles and/or challenges, and this ability seems to be related to the capacity to produce memories that draw on the pursuit of long-term goals, meaning making, emotional regulation, and/or activation of self-images (i.e., self-defining memories). These findings suggest that updating one's identity throughout life, at least in normal aging, may be related to the shaping and retrieval of self-defining memories, memories that lead to the creation of narrative scripts, which themse...
Source: Current Aging Science - October 9, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Dorsal White Matter Integrity and Name Retrieval in Midlife.
Authors: Kljajevic V, Erramuzpe A Abstract BACKGROUND: Recent findings on retrieval of proper names in cognitively healthy middle- aged persons indicate that Tip-Of-The-Tongue (TOT) states occurring during proper name retrieval implicate inferior frontal (BA 44) and parietal (BA 40) cortical areas. Such findings give rise to the possibility that anatomical connectivity via dorsal white matter may be associated with difficulties in name retrieval in midlife. Objectives & Method: Using Diffusion Tensor Imaging, we examined in vivo microstructural properties of white matter in 72 cognitively healthy Middle-Aged (M...
Source: Current Aging Science - October 9, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

The Association Between Diabetes and Cognitive Function in Later Life.
Authors: Momtaz YA, Hamid TA, Bagat MF, Hazrati M Abstract INTRODUCTION: Although diabetes through several possible mechanisms such as increased microvascular pathology and inefficiency of glucose utilization during cognitive tasks can be associated with cognitive impairment, there is inconclusive evidence that shows elderly diabetic patients under therapy have higher cognitive function compared to their non-diabetics counterparts. The present study was conducted to elucidate the association between diabetes and cognitive function in later life. METHODS: Data for this study, consisting of 2202 older adults aged...
Source: Current Aging Science - October 9, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

The Analysis of the Effects Executive Functions, Working Memory and other Factors on Medication Adherence in Elderly Men with Benign Prostatic Hyperplasia and Overactive Bladder Symptoms.
CONCLUSION: The status of executive function and working memory, as well as the age and severity of the pathological symptoms of lower urinary tract should be taken into account when predicting the risks of rejecting BPH and OAB treatment in elderly patients. PMID: 31560296 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - September 29, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Telomerase Biology Associations offer Keys to Cancer and Aging Therapeutics.
Authors: Sonneborn JS Abstract Although telomerase has potential for intervention in age-related diseases, the increased telomerase in about 90% of cancers, cautions against development of anti-aging therapeutics. The review here summarizes the multiple TERT (telomerase reverse transcriptase) telomerase subunit's unique associations that regulate cell functions that impact aging, cancer, and therapeutics. The TERT associations include proper folding, intracellular TERT transport, metabolism, mitochondrial ROS function, inflammation, cell division, cell death, and gene expression, in addition to the well-known telom...
Source: Current Aging Science - September 24, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Cholesterol and Dementia: A Long and Complicated Relationship.
CONCLUSION: Current state of knowledge makes the usage of cholesterol markers of cognitive decline in clinical practice impossible. PMID: 31530269 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - September 20, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Skin Ageing: Pathophysiology and Current Market Treatment Approaches.
Authors: Chaudhary M, Khan A, Gupta M Abstract Ageing is a natural phenomenon which is a fold, ridge and crease in the skin that occurs due to loss of body mass, poor hydration, disintegration of dermis and epidermis junction. The Skin ageing process involves many changes that occur due to the combination of both endogenous factors (gene mutation, cellular metabolism, and hormonal factor) and exogenous factors (U.V, pollutants, chemical, and toxins). In 1950, the number of older people were found to be almost 205 million across the globe. But this number almost got 4 times by the year 2012 and the number of older p...
Source: Current Aging Science - September 20, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

A hypothetical link between verbal fluency and functionality in aging: A systematic-review and paths for future research.
CONCLUSION: Theories suggest that VF might be associated with complex executive mechanisms. Still, a theoretical scheme and controlled researches possibly able to shed light on the underlying balance among the VF abilities and functionality within aging are, as yet, unknown. PMID: 31530271 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - September 20, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Effect of visual search training on saccades in age-related macular degeneration subjects.
Authors: Chatard H, Tepenier L, Beydoun T, Offret O, Salah S, Sahel JA, Mohand-Said S, Bucci MP Abstract OBJECTIVE: To compare the impact of unilateral versus bilateral age-related macular degeneration (AMD) on saccadic movements, and to show the effect of visual search training on these eye movement performances in AMD subjects. We hypothesized that unilateral and bilateral AMD subjects had abnormal saccadic performances, and that visual search training could improve their performances. METHODS: Three groups participated in visual search training: 13 elderly unilateral AMD subjects (mean age: 74.6 ± 1.6...
Source: Current Aging Science - September 14, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Bone Mineral Density Assessment By DXA Vs. QCT In Postmenopausal Females With Central Obesity.
Authors: Milisic L, Vegar-Zubovic S, Valjevac A, Hasanovic-Vučković S Abstract OBJECTIVES: Although dual-energy X-ray absorptiometry (DXA) is gold standard for osteoporosis diagnosis, several reports have shown discordant T-score values measured by quantitative computed tomography (QCT) and DXA especially in obese subjects, but it is still not clear whether BMD measurement by two modalities is affected by overall obesity or central obesity in postmenopausal females. Therefore, the aims of this study were to compare BMD and T-scores by DXA and QCT and to evaluate whether these two osteoporosis assessment modalitie...
Source: Current Aging Science - September 13, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

The Impact of Working Memory Training on Cognitive Abilities in Older Adults: The role of Cognitive Reserve.
CONCLUSION: Results of our study suggest that although the experimental group slightly improved their performance on the trained task, the progress was not statistically significant. There was also no statistically significant transfer of training effects onto tasks of visual-spatial and verbal memory, as well as those related to executive functioning. However, the study did identify a statistically significant correlation between cognitive reserve and certain tests performed at the final testing: tasks measuring executive functioning and spatial ability. Results also revealed that the group that showed improvement on the ...
Source: Current Aging Science - August 21, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Nigella sativa L., supplementary plant with anticholinesterase effect for cognition problems: A kinetic study.
CONCLUSIONS: N. sativa is a good candidate for seeking the new anticholinesterase agent and could be considered as a good supplement for the health of the elderly. PMID: 31418667 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - August 18, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Exploring the potential effect of Methanolic extract of Salvia officinalis against UV exposed skin aging: In vivo and In vitro model.
CONCLUSION: This study concluded that MeOH extract of Salvia officinalis has confirmed the high antioxidant potential and In vitro and In vivo inhibitory potential of antiaging enzymes assessed, thus they could be used for further development of cosmetic products and nutraceuticals. PMID: 31393258 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - August 10, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Meniscal Lesions in Geriatric Population: Prevalence and Association with Knee Osteoarthritis.
CONCLUSIONS: Our results demonstrated that meniscal damage is considerably prevalent among elderly individuals with knee pain, especially in those with knee OA. The fact that surgically target and possible-target lesions constitute a substantial proportion of these lesions should be considered in the clinical approach to these patients. PMID: 31264552 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - July 4, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Fuzzy Classification Methods Based Diagnosis of Parkinson's disease from Speech Test Cases.
Authors: Dastjerd NK, Sert OC, Ozyer T, Alhajj R Abstract Together with Alzheimer, Parkinson's disease is considered as one of two serious known neurodegenerative diseases. Physicians find it hard to predict whether a given patient has already developed or is expected to develop the Parkinson's disease in the future. To overcome this difficulty, it is possible to develop some computing model which analyzes the data related to a given patient and predicts with acceptable accuracy where he/she will develop the Parkinson's disease. This paper contributes an attractive prediction framework based on some machine learnin...
Source: Current Aging Science - June 28, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

The Role of Older Age in Normocytic Anaemia in Type 2 Diabetes Mellitus.
Authors: Wee YH, Anpalahan M Abstract BACKGROUND: Older age has a significant association with anaemia. However, this has not been adequately investigated in the context of specific comorbidities such as type 2 diabetes mellitus(T2DM). OBJECTIVES: To investigate the role of age in normocytic anaemia(NCA) and the adverse outcomes of NCA in T2DM. METHODS: Patients with NCA, either unexplained or related to chronic kidney disease(CKD), were recruited from a diabetic clinic over six months. Anaemia was defined as a haemoglobin(Hb)
Source: Current Aging Science - June 28, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Mobile-based technology for the management of chronic diseases in the elderly: A feasibility study.
CONCLUSION: The results showed that mHealth and remote medical technologies can be used for chronic disease management among elderly people. However, these technologies have some strengths and weaknesses. In order to succeed in the development and implementation of these projects, it is essential to consider probable threats and weaknesses before implementing the applications. PMID: 31223097 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - June 22, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

An Overview of Neuromuscular Junction Aging Findings in Human and Animal Studies.
CONCLUSION: The alterations in NMJs secondary to aging are inevitable. It is vital that neurologists clearly understand the pathophysiology of NMJ aging and differentiate between physiological and pathological effects of aging. With the current knowledge of science, the changes in NMJ aging can be better prevented rather than cured. PMID: 31161982 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - June 5, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Aging: Overview and Considerations for the Development of Geriatric Foods.
Authors: Kaur D, Rasane P, Singh J, Kaur S, Kumar V, Mahato DK, Dey A, Dhawan K, Kumar S Abstract The process of aging is characterized by numerous changes in the body which has an overall negative effect on the health and lifestyle of elderly. Nutrition deserves special attention as an individual reaches old age. It plays a vital role in affecting the quality of life, including physical, mental and social health. The physiological decline in food intake is very common among older age and this result in nutritional deficiencies. These increased nutritional deficiencies are the major risk factors for certain chronic...
Source: Current Aging Science - May 23, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

A systematic review of studies of the STOPP/START 2015 and American Geriatric Society Beers 2015 criteria.
CONCLUSIONS: PIP/PIM/PPO rates are high. RCTs are needed of interventions to: (1) reduce new/existing PIPs/PIMs/PPO prescriptions, (2) identify and reduce prescriptions causing adverse effects, and (3) enable regulatory authorities to closely monitor inappropriate prescriptions in real time and reduce rates. The substantial differences between individual medications identified by Beers and STOPP/START need investigating whether they are due to: content of the criteria lists, 2. medication availability in individual countries, 3.if authors applied all or subsets of criteria, or 4. physician prescribing preferences. PMID...
Source: Current Aging Science - May 19, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Age-related diazinon toxicity impact on blood glucose, lipid profile and selected biochemical indices in male rats.
Authors: Yousefizadeh S, Farkhondeh T, Samarghandian S Abstract Diabetes and its complications are age-related diseases. Low grade inflammation plays the main role in the initiation and progression of aging processes. Diazinon (DZN), an organophosphate pesticide, has been found to induce metabolic disturbances. The present study was designed to investigate the impact of DZN on age-related changes on inflammatory cells, blood glucose concentration, lipid profile, and liver and kidney function indices. Male Wistar rats (2and 16 month-old) were orally administrated with DZN (15 mg/kg) for 4 weeks. The results i...
Source: Current Aging Science - May 2, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Brain ageing, cognition and diet: a review of the emerging roles of food-based nootropics in mitigating age-related memory decline.
CONCLUSION: While it is known that the human brain endures diverse insults in the process of ageing, food-based nootropics are likely to go a long way in mitigating the impacts of these insults. Further research is needed before we reach a point where food-based nootropics are routinely prescribed. PMID: 30864515 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - March 14, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Detecting Non-cognitive Features of Prodromal Neurodegenerative Diseases.
CONCLUSIONS: Our findings suggest that non-cognitive features can be reliably measured by selfreport in busy clinical settings and such measurement can be useful in distinguishing patients with different etiologies of ND. Better characterization of unique, prodromal, non-cognitive ND trajectories could improve public health efforts to increase access to prodromal ND detection during the most modifiable disease stages. PMID: 30845903 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - March 10, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Focus on the Different Projects of Telemedicine Centered on the Elderly In France.
Authors: Zulfiqar AA, Hajjam A, Andrès E Abstract Telemedicine is now in vogue, allowing computer and communication tools to be deployed in different fields of health, such as Cardiology, Dermatology, areas in which it has received interest, and in international studies. As the population ages, older people are increasingly concerned about this innovative practice. This is a narrative review of both the literature and Internet pertaining to telemedicine projects within the field of geriatric subjects in France. Since the beginning of the 2000's, several telemedicine projects and trials focused on chronic hea...
Source: Current Aging Science - March 7, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Impact of cardiovascular factors on pulse wave velocity and total vascular resistance in different age group patients with cardiovascular disorders.
Conclusion Despite the limitations, like unequal number of male and female participants, wide variation of the age of the subjects and analyzing association of many factors at a time, our large and community-based study shows individual blood pressure and pulse pressure depend on complex interaction between large arteries and arterioles. This study sheds light on the relationship between proximal and distal part (PWV and TVR) of the arterial tree as well as their association with different hemodynamic and non-hemodynamic parameters. PMID: 30813882 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - March 5, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Effects of Ageing on the Mitochondrial Genome in Rat Vestibular Organs.
CONCLUSION: Given the importance of mtDNA to mitochondrial OXPHOS and hair cell function, our findings suggest the vestibular organs are potentially on the brink of an energy crisis in old animals. PMID: 30777575 [PubMed - in process] (Source: Current Aging Science)
Source: Current Aging Science - February 21, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Inflammatory biomarkers, depressive symptoms and falls among the elderly in Panama.
CONCLUSION: There is a lack of research investigating the relationship between inflammatory biomarkers and fall events. These results provide evidence of risk factors for falls in Hispanic older adults, and could serve to guide public health professionals to establish clinical guidelines to reduce fall risks. PMID: 30767759 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - February 17, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Mitochondrial common deletion level in blood: New insight into the effects of age and Body Mass Index.
CONCLUSION: Our data suggest that the age affects purifying selection and BMI, which may influence the relative level of the mtDNA common deletion in blood. PMID: 30714539 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - February 6, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

The Effects of Healthy Ageing on Cerebral Blood Flow Responses to Cognitive Testing.
Conclusions Healthy older adults demonstrate augmented cerebrovascular physiology in response to cognitive challenge compared to younger adults. The impact of abnormal ageing on cerebrovascular physiology, for example related to cognitively impaired states, requires further investigation. PMID: 30706798 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - February 3, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Changes in Body Composition of Old Rats at Different Time Points after Dexamethasone Administration.
CONCLUSION: This study demonstrated that a 10-day period of overexprosure to glycocorticoids induced longlasting changes in old rats' body composition and these values did not attain the baseline level even after 20-day recovery period. PMID: 30648531 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - January 18, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Oxidative and Inflammatory Events in Prion Diseases: Can They Be Therapeutic Targets?
Authors: Prasad KN, Bondy SC Abstract Prion diseases are a group of incurable infectious terminal neurodegenerative diseases caused by the aggregated misfolded PrPsc in selected mammals including humans. The complex physical interaction between normal prion protein PrPc and infectious PrPsc causes conformational change from the α- helix structure of PrPc to the β-sheet structure of PrPsc, and this process is repeated. Increased oxidative stress is one of the factors that facilitate conversion of PrPc to PrPsc. This overview presents evidence to show that increased oxidative stress and inflammation are in...
Source: Current Aging Science - January 15, 2019 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Cognitive Function Prediction of Performance During Dual-Tasks Across Adults With and Without Hearing Loss.
CONCLUSIONS: Cognitive function may predict dual-task performance during speech-in-noise tasks. Further research investigating the predictive value of related cognitive subtests to listening effort is warranted. PMID: 30543178 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - December 15, 2018 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

A Rare Diagnosis After the Fall of a 96-Year-Old Woman: Doege-Potter Syndrome.
CONCLUSION: In this case report we describe an uncommon cause of paraneoplastic hypoglycemia occurring in the oldest patient with a non-islet cell tumor reported thus far. PMID: 30520387 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - December 8, 2018 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Four Principles regarding an Effective Treatment of Aging.
Authors: Kyriazis M Abstract The question whether aging is a disease or not, has been asked by many professionals who are involved in the study of age-related degeneration. However, not only an agreement on this remains elusive, but also effective clinical treatments against human aging have not been forthcoming. In this Opinion paper I suggest that the complexity involved in aging is such that we need to remodel our thinking to involve a much more 'systems-oriented' approach. I explore four main principles which should be employed by those who are working on finding treatments against age-related degeneration. Fir...
Source: Current Aging Science - October 28, 2018 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Behavioral Assessment and Blood Oxidative Status of Aging Sprague Dawley Rats through a Longitudinal Analysis.
Conclusion The progressions of cognitive impairment in normal aging rats are linked to the increment in the level of DNA damage. PMID: 30338748 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - October 20, 2018 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Daily Living Activities and Cognition in Aged Patients: Effect of Acute Systemic Diseases and Stroke on Leukoaraiosis.
CONCLUSIONS: ASD in ExL-A causes a worsening of DLA and cognition similar to that observed in ExL-A with concomitant stroke indicating the need, in ageing patients, of differential diagnosis in order to achieve the best possible treatment. PMID: 30338749 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - October 20, 2018 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Development, application, and results from a precision-medicine platform that personalizes multi-modal treatment plans for mild Alzheimer's disease and at-risk individuals.
CONCLUSIONS: Our analysis on these individuals lead to several interesting observations together suggesting that AD risk factors comprise a network of interlocking feedback loops that may be modifiable. Our findings indicate previously unidentified connectivity between AD risk factors, suggesting that treatment regimens should be tailored to the individual and multi-modal to simultaneously return several risk factors to a normative state. If successfully performed, the possibility to slow progression of AD and possibly reverse aspects of cognitive decline may become achievable. PMID: 30338750 [PubMed - as supplied by p...
Source: Current Aging Science - October 20, 2018 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Lifestyle patterns as a modifiable risk factor for late-life cognitive decline: a narrative review regarding dementia prevention.
CONCLUSION: Despite all evidence regarding modifiable risk factors possibly reducing the risk of developing dementia in later life, many unanswered questions remain regarding the direct influence of these variables in later life. People who regularly and actively participate in different lifelong activities (social, cultural and intellectual) do tend to perform better on formal cognitive tests, experience fewer cognitive complaints, and are less likely to develop neurodegenerative disorders. PMID: 30280679 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - October 5, 2018 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Altered gene expression of muscle satellite cells contributes to age-related sarcopenia in mice.
CONCLUSION: Our analysis reveals that by altering gene expression pattern and expressing inflammatory mediators and extracellular matrix components, these cells can directly contribute to muscle wasting in aged mice. PMID: 30251615 [PubMed - as supplied by publisher] (Source: Current Aging Science)
Source: Current Aging Science - September 28, 2018 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Understanding Healthy Protective Mechanisms Against Old Age.
Authors: Lahiri DK PMID: 30095049 [PubMed - in process] (Source: Current Aging Science)
Source: Current Aging Science - August 11, 2018 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

Looking Towards New Pathogenetic Mechanisms in Parkinson's Disease: is ANT1 the Potential Candidate?
Authors: Naro A, Cimino V, Portaro S, Calabro RS PMID: 30095050 [PubMed - in process] (Source: Current Aging Science)
Source: Current Aging Science - August 11, 2018 Category: Geriatrics Tags: Curr Aging Sci Source Type: research