Evaluation of histological and ultrastructural changes provoked by prenatal tramadol on postnatal cortical cerebellar neuronal development in rats: possible implication of Ki67, GFAP and MicroRNA-7/P53 signalling trajectories
J Mol Histol. 2024 Apr 19. doi: 10.1007/s10735-024-10189-2. Online ahead of print.ABSTRACTTramadol is a novel centrally acting analgesic. Despite, its implementation during pregnancy may impair neuronal survival and synaptic development in neonatal cerebella. The current investigation assessed the histological and ultrastructural alterations in postnatal cortical cerebellar neuronal development induced by prenatal tramadol. 30 offsprings were divided to control group I: fifteen pups born to mothers given saline from D10 till D21 of gestation. Tramadol-treated group II: fifteen pups born to mothers received tramadol HCL (50...
Source: Molecular Medicine - April 19, 2024 Category: Molecular Biology Authors: Walaa Adel Abdelmoez Source Type: research
Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension
CONCLUSIONS: These data support the pathogenic role of CypD acetylation in endothelial dysfunction and hypertension. We suggest that targeting cytotoxic mitochondrial isolevuglandins and GCN5L1 reduces CypD acetylation, which may be beneficial in cardiovascular disease.PMID:38639088 | DOI:10.1161/CIRCRESAHA.123.323596 (Source: Circulation Research)
Source: Circulation Research - April 19, 2024 Category: Cardiology Authors: Anna Dikalova Daniel Fehrenbach Vladimir Mayorov Alexander Panov Mingfang Ao Louise Lantier Venkataraman Amarnath Marcos G Lopez Frederic T Billings Iv Michael N Sack Sergey Dikalov Source Type: research
DNA repair deficiencies and neurodegeneration
DNA Repair (Amst). 2024 Apr 16;138:103679. doi: 10.1016/j.dnarep.2024.103679. Online ahead of print.ABSTRACTNeurodegenerative diseases are the second most prevalent cause of death in industrialized countries. Alzheimer's Disease is the most widespread and also most acknowledged form of dementia today. Together with Parkinson's Disease they account for over 90 % cases of neurodegenerative disorders caused by proteopathies. Far less known are the neurodegenerative pathologies in DNA repair deficiency syndromes. Such diseases like Cockayne - or Werner Syndrome are described as progeroid syndromes - diseases that cause the pre...
Source: DNA Repair - April 19, 2024 Category: Genetics & Stem Cells Authors: Baptiste Ropert Christian Gallrein Bj örn Schumacher Source Type: research
DNA repair deficiencies and neurodegeneration
DNA Repair (Amst). 2024 Apr 16;138:103679. doi: 10.1016/j.dnarep.2024.103679. Online ahead of print.ABSTRACTNeurodegenerative diseases are the second most prevalent cause of death in industrialized countries. Alzheimer's Disease is the most widespread and also most acknowledged form of dementia today. Together with Parkinson's Disease they account for over 90 % cases of neurodegenerative disorders caused by proteopathies. Far less known are the neurodegenerative pathologies in DNA repair deficiency syndromes. Such diseases like Cockayne - or Werner Syndrome are described as progeroid syndromes - diseases that cause the pre...
Source: DNA Repair - April 19, 2024 Category: Genetics & Stem Cells Authors: Baptiste Ropert Christian Gallrein Bj örn Schumacher Source Type: research
Evaluation of histological and ultrastructural changes provoked by prenatal tramadol on postnatal cortical cerebellar neuronal development in rats: possible implication of Ki67, GFAP and MicroRNA-7/P53 signalling trajectories
AbstractTramadol is a novel centrally acting analgesic. Despite, its implementation during pregnancy may impair neuronal survival and synaptic development in neonatal cerebella. The current investigation assessed the histological and ultrastructural alterations in postnatal cortical cerebellar neuronal development induced by prenatal tramadol. 30 offsprings were divided tocontrol group I: fifteen pups born to mothers given saline from D10 till D21 of gestation.Tramadol-treated group II: fifteen pups born to mothers received tramadol HCL (50 mg/kg/day) from D10 till D21 of gestation. Pups were categorized into three subgr...
Source: Journal of Molecular Histology - April 19, 2024 Category: Laboratory Medicine Source Type: research
Mitochondria protective and anti-apoptotic effects of peripheral benzodiazepine receptor and its ligands on the treatment of asthma in vitro and vivo
Asthma is a prevalent respiratory inflammatory disease. Abnormal apoptosis of bronchial epithelial cells is one of the major factors in the progression of asthma. Peripheral benzodiazepine receptors are highly... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 19, 2024 Category: Allergy & Immunology Authors: Yurui Liu, Zhengze Zhang, Yuewen He, Ruogen Li, Yuhao Zhang, Hao Liu, Yong Wang and Wuhua Ma Tags: Research Source Type: research
TBBPS caused necroptosis and inflammation in hepatocytes by blocking PINK1-PARKIN-mediated mitochondrial autophagy
Tissue Cell. 2024 Apr 10;88:102382. doi: 10.1016/j.tice.2024.102382. Online ahead of print.ABSTRACTThe widespread use of Tetrabromobisphenol S (TBBPS), as an alternative to tetrabromobisphenol A (TBBPA), has been detected at high frequency in environmental media in recent years, TBBPS can enter the body via the digestive tract and other routes, thus long-term TBBPS exposure may cause adverse health effects. Therefore, it is necessary to evaluate the toxicological effects of TBBPS. In the current work, two cell models of the liver were used (a human-derived cell line THLE-2 and a murine-derived AML12). The liver cells were ...
Source: Tissue and Cell - April 18, 2024 Category: Cytology Authors: Yujun Yin Minshi Huang Jianlong Xie Yongfang Ou Tianfu Mai Source Type: research
Effect of 2-aminoethoxydiphenyl borate on the functions of mouse skeletal muscle mitochondria
Biochem Biophys Res Commun. 2024 Apr 16;712-713:149944. doi: 10.1016/j.bbrc.2024.149944. Online ahead of print.ABSTRACTThis work examined the effect of 2-aminoethoxydiphenyl borate (2-APB) on the functioning of isolated mouse skeletal muscle mitochondria and modeled its putative interaction with mitochondrial proteins. We have shown that 2-APB is able to dose-dependently suppress mitochondrial respiration in state 3 and 3UDNP driven by substrates of complex I and II. This effect of 2-APB was accompanied by a slight dose-dependent decrease in mitochondrial membrane potential and appears to be due to inhibition of complex I ...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Mikhail V Dubinin Alexander V Chulkov Anastasia D Igoshkina Alena A Cherepanova Natalia V Mikina Source Type: research
TBBPS caused necroptosis and inflammation in hepatocytes by blocking PINK1-PARKIN-mediated mitochondrial autophagy
Tissue Cell. 2024 Apr 10;88:102382. doi: 10.1016/j.tice.2024.102382. Online ahead of print.ABSTRACTThe widespread use of Tetrabromobisphenol S (TBBPS), as an alternative to tetrabromobisphenol A (TBBPA), has been detected at high frequency in environmental media in recent years, TBBPS can enter the body via the digestive tract and other routes, thus long-term TBBPS exposure may cause adverse health effects. Therefore, it is necessary to evaluate the toxicological effects of TBBPS. In the current work, two cell models of the liver were used (a human-derived cell line THLE-2 and a murine-derived AML12). The liver cells were ...
Source: Tissue and Cell - April 18, 2024 Category: Cytology Authors: Yujun Yin Minshi Huang Jianlong Xie Yongfang Ou Tianfu Mai Source Type: research
Methylated urolithin A, mitigates cognitive impairment by inhibiting NLRP3 inflammasome and ameliorating mitochondrial dysfunction in aging mice
In conclusion, mUro A alleviates cognitive impairment in aging mice by suppressing neuroinflammation through NLRP3 inflammasome inhibition and restoring mitochondrial function via the p53-PGC-1α pathway. This suggests its potential therapeutic agent for brain aging and aging-related diseases.PMID:38636727 | DOI:10.1016/j.neuropharm.2024.109950 (Source: Neuropharmacology)
Source: Neuropharmacology - April 18, 2024 Category: Drugs & Pharmacology Authors: Peng Chen Yulai Wang Jing Xie Jiexin Lei Benhong Zhou Source Type: research
The use of amino acids and their derivates to mitigate against pesticide-induced toxicity
Ecotoxicol Environ Saf. 2024 Apr 17;276:116340. doi: 10.1016/j.ecoenv.2024.116340. Online ahead of print.ABSTRACTExposure to pesticides induces oxidative stress and deleterious effects on various tissues in non-target organisms. Numerous models investigating pesticide exposure have demonstrated metabolic disturbances such as imbalances in amino acid levels within the organism. One potentially effective strategy to mitigate pesticide toxicity involves dietary intervention by supplementing exogenous amino acids and their derivates to augment the body's antioxidant capacity and mitigate pesticide-induced oxidative harm, whose...
Source: Ecotoxicology and Environmental Safety - April 18, 2024 Category: Environmental Health Authors: Guo-Ping Zhao Wei-Long Cheng Zhi-Hui Zhang Yi-Xuan Li Ying-Qiu Li Fang-Wei Yang Yan-Bo Wang Source Type: research
Salvia miltiorrhiza polysaccharide mitigates AFB1-induced liver injury in rabbits
Ecotoxicol Environ Saf. 2024 Apr 17;276:116344. doi: 10.1016/j.ecoenv.2024.116344. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1) is one of the common dietary contaminants worldwide, which can harm the liver of humans and animals. Salvia miltiorrhiza polysaccharide (SMP) is a natural plant-derived polysaccharide with numerous pharmacological activities, including hepatoprotective properties. The purpose of this study is to explore the intervention effect of SMP on AFB1-induced liver injury and its underlying mechanisms in rabbits. The rabbits were administered AFB1 (25 μg/kg/feed) and or treatment with SMP (300, 600, 9...
Source: Ecotoxicology and Environmental Safety - April 18, 2024 Category: Environmental Health Authors: Lu Zhang Ying Liu Qiongyi Zhang Weiyu Yao Zenghui Zhao Xiao Wang Yongzhan Bao Wanyu Shi Source Type: research
Effect of 2-aminoethoxydiphenyl borate on the functions of mouse skeletal muscle mitochondria
Biochem Biophys Res Commun. 2024 Apr 16;712-713:149944. doi: 10.1016/j.bbrc.2024.149944. Online ahead of print.ABSTRACTThis work examined the effect of 2-aminoethoxydiphenyl borate (2-APB) on the functioning of isolated mouse skeletal muscle mitochondria and modeled its putative interaction with mitochondrial proteins. We have shown that 2-APB is able to dose-dependently suppress mitochondrial respiration in state 3 and 3UDNP driven by substrates of complex I and II. This effect of 2-APB was accompanied by a slight dose-dependent decrease in mitochondrial membrane potential and appears to be due to inhibition of complex I ...
Source: Biochemical and Biophysical Research communications - April 18, 2024 Category: Biochemistry Authors: Mikhail V Dubinin Alexander V Chulkov Anastasia D Igoshkina Alena A Cherepanova Natalia V Mikina Source Type: research
Synergistic Regulation of Targeted Organelles in Tumor Cells to Promote Photothermal ‐Immunotherapy Using Intelligent Core‐Satellite‐Like Nanoparticles for Effective Treatment of Breast Cancer
Herein, an intelligent nanoplatform (BMAEF) is fabricated to perform on-demand destruction of mitochondria and golgi apparatus, which also generates the enhanced photothermal therapy and immunotherapy, resulting in the effective inhibition of primary and metastasis tumor against breast cancer. The BMAEF has a core of mesoporous silica nanoparticles loaded with brefeldin A (BM), which is further connected to ethylenebis(oxyethylenenitrilo)tetraacetic acid and folic acid co-modified gold nanoparticles (AEF). AbstractThe normal operation of organelles is critical for tumor growth and metastasis. Herein, an intelligent nanopla...
Source: Small - April 18, 2024 Category: Nanotechnology Authors: Xiaowei Chang,
Xiaoyu Tang,
Wenjun Tang,
Lin Weng,
Tao Liu,
Zeren Zhu,
Jie Liu,
Man Zhu,
Yanmin Zhang,
Xin Chen Tags: Research Article Source Type: research
Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care —clinically relevant 3PM innovation
AbstractDespite their subordination in humans, to a great extent, mitochondria maintain their independent status but tightly cooperate with the “host” on protecting the joint life quality and minimizing health risks. Under oxidative stress conditions, healthy mitochondria promptly increase mitophagy level to remove damaged “fellows” rejuvenating the mitochondrial population and sending fragments of mtDNA as SOS signals to all system s in the human body. As long as metabolic pathways are under systemic control and well-concerted together, adaptive mechanisms become triggered increasing systemic protection, activatin...
Source: EPMA Journal - April 18, 2024 Category: International Medicine & Public Health Source Type: research
