Synergistic Regulation of Targeted Organelles in Tumor Cells to Promote Photothermal ‐Immunotherapy Using Intelligent Core‐Satellite‐Like Nanoparticles for Effective Treatment of Breast Cancer

Herein, an intelligent nanoplatform (BMAEF) is fabricated to perform on-demand destruction of mitochondria and golgi apparatus, which also generates the enhanced photothermal therapy and immunotherapy, resulting in the effective inhibition of primary and metastasis tumor against breast cancer. The BMAEF has a core of mesoporous silica nanoparticles loaded with brefeldin A (BM), which is further connected to ethylenebis(oxyethylenenitrilo)tetraacetic acid and folic acid co-modified gold nanoparticles (AEF). AbstractThe normal operation of organelles is critical for tumor growth and metastasis. Herein, an intelligent nanoplatform (BMAEF) is fabricated to perform on-demand destruction of mitochondria and golgi apparatus, which also generates the enhanced photothermal-immunotherapy, resulting in the effective inhibition of primary and metastasis tumor. The BMAEF has a core of mesoporous silica nanoparticles loaded with brefeldin A (BM), which is connected to ethylenebis(oxyethylenenitrilo)tetraacetic acid (EGTA) and folic acid co-modified gold nanoparticles (AEF). During therapy, the BMAEF first accumulates in tumor cells via folic acid-induced targeting. Subsequently, the schiff base/ester bond cleaves in lysosome to release brefeldin A and AEF with exposed EGTA. The EGTA further captures Ca2+ to block ion transfer among mitochondria, endoplasmic reticulum, and golgi apparatus, which not only induced dysfunction of mitochondria and golgi apparatus assisted by brefeldin A to supp...

Source: Small - April 18, 2024 Category: Nanotechnology Authors: Xiaowei Chang, Xiaoyu Tang, Wenjun Tang, Lin Weng, Tao Liu, Zeren Zhu, Jie Liu, Man Zhu, Yanmin Zhang, Xin Chen Tags: Research Article Source Type: research