Altered lactate/pyruvate ratio may be responsible for aging-associated intestinal barrier dysfunction in male rats
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10102-0. Online ahead of print.ABSTRACTSome evidence points to a link between aging-related increased intestinal permeability and mitochondrial dysfunction in in-vivo models. Several studies have also demonstrated age-related accumulation of the of specific deletion 4834-bp of "common" mitochondrial DNA (mtDNA) in various rat tissues and suggest that this deletion may disrupt mitochondrial metabolism. The present study aimed to investigate possible associations among the mitochondrial DNA (mtDNA) common deletion, mitochondrial function, intestinal permeability, and aging...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Berrin Papila Ayla Karimova Ilhan Onaran Source Type: research
The role and mechanism of PDZ binding kinase in hypobaric and hypoxic acute lung injury
CONCLUSIONS: Overexpression of PBK inhibits the expression of p53 and activates SIRT1-PINK1 axis mediated mitochondrial autophagy to alleviate HHALI.PMID:38617778 | PMC:PMC11009593 | DOI:10.21037/jtd-24-188 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Linao Sun Haoran Yue Hao Fang Runze Li Shicong Li Jianyao Wang Pengjie Tu Fei Meng Wang Yan Jinxia Zhang Elena Bignami Kyeongman Jeon Biniam Kidane Peng Zhang Source Type: research
Role of mitochondria in doxorubicin-mediated cardiotoxicity: from molecular mechanisms to therapeutic strategies
In conclusion, this review offers valuable insights into the intricate relationship between mitochondrial dysfunction and doxorubicin-mediated cardiotoxicity. It underscores the need for continued research into targeted mitochondrial therapies as a means to improve the cardiac safety profile of doxorubicin, thereby enhancing the overall treatment outcomes for cancer patients.PMID:38617011 | PMC:PMC11008476 | DOI:10.7150/ijms.94485 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Tianen Wang Guoli Xing Tong Fu Yanchun Ma Qi Wang Shuxiang Zhang Xing Chang Ying Tong Source Type: research
Protective Effect of Fermented Sea Tangle Extract on Skin Cell Damage Caused by Particulate Matter
Int J Med Sci. 2024 Mar 31;21(5):937-948. doi: 10.7150/ijms.93034. eCollection 2024.ABSTRACTThe skin is directly exposed to atmospheric pollutants, especially particulate matter 2.5 (PM2.5) in the air, which poses significant harm to skin health. However, limited research has been performed to identify molecules that can confer resistance to such substances. Herein, we analyzed the effect of fermented sea tangle (FST) extract on PM2.5-induced human HaCaT keratinocyte damage. Results showed that FST extract, at concentrations less than 800 μg/mL, exhibited non-significant toxicity to cells and concentration-dependent inhib...
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Mei Jing Piao Kyoung Ah Kang Pincha Devage Sameera Madushan Fernando Herath Mudiyanselage Udari Lakmini Herath Young Sang Koh Hee Kyoung Kang Yung Hyun Choi Jin Won Hyun Source Type: research
Altered lactate/pyruvate ratio may be responsible for aging-associated intestinal barrier dysfunction in male rats
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10102-0. Online ahead of print.ABSTRACTSome evidence points to a link between aging-related increased intestinal permeability and mitochondrial dysfunction in in-vivo models. Several studies have also demonstrated age-related accumulation of the of specific deletion 4834-bp of "common" mitochondrial DNA (mtDNA) in various rat tissues and suggest that this deletion may disrupt mitochondrial metabolism. The present study aimed to investigate possible associations among the mitochondrial DNA (mtDNA) common deletion, mitochondrial function, intestinal permeability, and aging...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Berrin Papila Ayla Karimova Ilhan Onaran Source Type: research
The role and mechanism of PDZ binding kinase in hypobaric and hypoxic acute lung injury
CONCLUSIONS: Overexpression of PBK inhibits the expression of p53 and activates SIRT1-PINK1 axis mediated mitochondrial autophagy to alleviate HHALI.PMID:38617778 | PMC:PMC11009593 | DOI:10.21037/jtd-24-188 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Linao Sun Haoran Yue Hao Fang Runze Li Shicong Li Jianyao Wang Pengjie Tu Fei Meng Wang Yan Jinxia Zhang Elena Bignami Kyeongman Jeon Biniam Kidane Peng Zhang Source Type: research
Role of mitochondria in doxorubicin-mediated cardiotoxicity: from molecular mechanisms to therapeutic strategies
In conclusion, this review offers valuable insights into the intricate relationship between mitochondrial dysfunction and doxorubicin-mediated cardiotoxicity. It underscores the need for continued research into targeted mitochondrial therapies as a means to improve the cardiac safety profile of doxorubicin, thereby enhancing the overall treatment outcomes for cancer patients.PMID:38617011 | PMC:PMC11008476 | DOI:10.7150/ijms.94485 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Tianen Wang Guoli Xing Tong Fu Yanchun Ma Qi Wang Shuxiang Zhang Xing Chang Ying Tong Source Type: research
Protective Effect of Fermented Sea Tangle Extract on Skin Cell Damage Caused by Particulate Matter
Int J Med Sci. 2024 Mar 31;21(5):937-948. doi: 10.7150/ijms.93034. eCollection 2024.ABSTRACTThe skin is directly exposed to atmospheric pollutants, especially particulate matter 2.5 (PM2.5) in the air, which poses significant harm to skin health. However, limited research has been performed to identify molecules that can confer resistance to such substances. Herein, we analyzed the effect of fermented sea tangle (FST) extract on PM2.5-induced human HaCaT keratinocyte damage. Results showed that FST extract, at concentrations less than 800 μg/mL, exhibited non-significant toxicity to cells and concentration-dependent inhib...
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Mei Jing Piao Kyoung Ah Kang Pincha Devage Sameera Madushan Fernando Herath Mudiyanselage Udari Lakmini Herath Young Sang Koh Hee Kyoung Kang Yung Hyun Choi Jin Won Hyun Source Type: research
The Evaluation of Mass/DNA Copy Number of Mitochondria in Umbilical Cord Blood-derived Hematopoietic Stem Cells Cocultured with MSCs
AbstractOver recent decades, UCB has been widely used as an excellent alternative source of HSCs for treating many hematologic disorders. Recent studies suggest using mesenchymal stroma cell co-cultures to increase the number of HSCs prior to transplantation. Considering the critical role of mitochondria in the cell's fate and the importance of the self-renewal capacity of HSCs in HSCT, we decided to investigate the mass/DNA copy number of mitochondria in HSCs while co-cultured with MSCs and alone after seven days. UCB units were collected from full-term deliveries. MSCs and HSCs were isolated from UCB and the purity of ce...
Source: Indian Journal of Hematology and Blood Transfusion - April 15, 2024 Category: Hematology Source Type: research
Health risk assessment of heavy metal(loid)s in road dust via dermal exposure pathway from a low latitude plateau provincial capital city: The importance of toxicological verification
In this study, the road dust samples were harvested from a typical low-latitude plateau provincial capital city Kunming, Southwest China. The total concentration and dermal bioaccessibility of heavy metal(loid)s in road dust were determined, and their health risks and cytotoxicity on human skin keratinocytes were also assessed. The average concentrations of As (28.5 mg/kg), Cd (2.65 mg/kg), Mn (671 mg/kg), and Zn (511 mg/kg) exceeded the soil background values. Arsenic had the highest bioaccessibility after 2 h (3.79%), 8 h (4.24%), and 24 h (16.6%) extraction. Although soil assessment methods showed no health risk in the ...
Source: Cell Research - April 14, 2024 Category: Cytology Authors: Jingya Li Daolei Cui Ziyue Yang Jiaoyang Ma Jianjun Liu Yingxin Yu Xianfeng Huang Ping Xiang Source Type: research
Urolithin a inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages
CONCLUSION: Our study elucidated the anti-breast cancer effect of UA from the perspective of tumor-associated macrophages. Specifically, TFEB is a crucial downstream target in macrophages.PMID:38615740 | DOI:10.1016/j.jare.2024.04.010 (Source: Cell Research)
Source: Cell Research - April 14, 2024 Category: Cytology Authors: Bowen Zheng Yuying Wang Baian Zhou Fengyuan Qian Diya Liu Danrong Ye Xiqian Zhou Lin Fang Source Type: research
Isobavachin attenuates osteoclastogenesis and periodontitis-induced bone loss by inhibiting cellular iron accumulation and mitochondrial biogenesis
Biochem Pharmacol. 2024 Apr 12:116202. doi: 10.1016/j.bcp.2024.116202. Online ahead of print.ABSTRACTAs bone-resorbing cells rich in mitochondria, osteoclasts require high iron uptake to promote mitochondrial biogenesis and maintain a high-energy metabolic state for active bone resorption. Given that abnormal osteoclast formation and activation leads to imbalanced bone remodeling and osteolytic bone loss, osteoclasts may be crucial targets for treating osteolytic diseases such as periodontitis. Isobavachin (IBA), a natural flavonoid compound, has been confirmed to be an inhibitor of receptor activator of nuclear factor κB...
Source: Biochemical Pharmacology - April 14, 2024 Category: Drugs & Pharmacology Authors: Ting Li Yangge Du Hantao Yao Boxuan Zhao Zijun Wang Rourong Chen Yaoting Ji Minquan Du Source Type: research
Nanomaterials-induced programmed cell death: Focus on mitochondria
Toxicology. 2024 Apr 12:153803. doi: 10.1016/j.tox.2024.153803. Online ahead of print.ABSTRACTNanomaterials are widely utilized in several domains, such as everyday life, societal manufacturing, and biomedical applications, which expand the potential for nanomaterials to penetrate biological barriers and interact with cells. Multiple studies have concentrated on the particular or improper utilization of nanomaterials, resulting in cellular death. The primary mode of cell death caused by nanotoxicity is programmable cell death, which includes apoptosis, ferroptosis, necroptosis, and pyroptosis. Based on our prior publicatio...
Source: Toxicology - April 14, 2024 Category: Toxicology Authors: Shijia Qiao Yiyuan Kang Xiner Tan Xinru Zhou Can Zhang Shulin Lai Jia Liu Longquan Shao Source Type: research
BmNPV p35 regulates apoptosis in Bombyx mori via a novel target of interaction with the BmVDAC2-BmRACK1 complex
In this study, the interaction between BmVDAC2 and BmRACK1 in the mitochondria was determined by various methods. We found that BmNPV p35 interacts directly with BmVDAC2 rather than BmRACK1. BmNPV infection significantly reduced the expression of BmVDAC2, and activated the mitochondrial apoptosis pathway. Overexpression of BmVDAC2 in BmN cells inhibited BmNPV-induced cytochrome c (cyto c) release, decrease in mitochondrial membrane potential as well as apoptosis. Additionally, the inhibition of cyto c release by BmVDAC2 requires the involvement of BmRACK1 and protein kinase C. Interestingly, overexpression of p35 inhibited...
Source: Insect Biochemistry and Molecular Biology - April 14, 2024 Category: Biochemistry Authors: Lin-Bao Zhu Han-Dan Zhu Zhi-Hao Huang Hui-Hua Cao Sadaf Ayaz Jia-Yue Yang Xi-Ya Chen Ying Zhang Shi-Huo Liu Jia-Ping Xu Source Type: research
Isobavachin attenuates osteoclastogenesis and periodontitis-induced bone loss by inhibiting cellular iron accumulation and mitochondrial biogenesis
Biochem Pharmacol. 2024 Apr 12:116202. doi: 10.1016/j.bcp.2024.116202. Online ahead of print.ABSTRACTAs bone-resorbing cells rich in mitochondria, osteoclasts require high iron uptake to promote mitochondrial biogenesis and maintain a high-energy metabolic state for active bone resorption. Given that abnormal osteoclast formation and activation leads to imbalanced bone remodeling and osteolytic bone loss, osteoclasts may be crucial targets for treating osteolytic diseases such as periodontitis. Isobavachin (IBA), a natural flavonoid compound, has been confirmed to be an inhibitor of receptor activator of nuclear factor κB...
Source: Biochemical Pharmacology - April 14, 2024 Category: Drugs & Pharmacology Authors: Ting Li Yangge Du Hantao Yao Boxuan Zhao Zijun Wang Rourong Chen Yaoting Ji Minquan Du Source Type: research
